SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_E_Z80E401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eqc | EXO-(B)-(1,3)-GLUCANASE (Candidaalbicans) |
PF00150(Cellulase) | 5 | ILE A 15VAL A 289ASN A 191ASP A 133ILE A 224 | NoneNoneCTS A 401 (-3.1A)NoneNone | 1.00A | 5lg3E-1eqcA:0.0 | 5lg3E-1eqcA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2a | HYDROGENASE (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | ILE S 71THR S 160ASN S 156ILE S 145ALA S 144 | None | 1.11A | 5lg3E-1h2aS:0.0 | 5lg3E-1h2aS:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hdg | HOLO-D-GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE (Thermotogamaritima) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ILE O 93PHE O 91ASN O 22ILE O 25ALA O 1 | None | 1.05A | 5lg3E-1hdgO:undetectable | 5lg3E-1hdgO:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jv4 | MAJOR URINARYPROTEIN 2 (Mus musculus) |
PF00061(Lipocalin) | 5 | ILE A 15ILE A 45VAL A 12GLU A 49ALA A 71 | None | 1.08A | 5lg3E-1jv4A:undetectable | 5lg3E-1jv4A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nhc | POLYGALACTURONASE I (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 5 | ILE A 190ILE A 210PHE A 220VAL A 160ALA A 201 | None | 0.71A | 5lg3E-1nhcA:undetectable | 5lg3E-1nhcA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qq0 | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 5 | ILE A 161ILE A 167THR A 131ILE A 133ALA A 137 | None | 0.85A | 5lg3E-1qq0A:undetectable | 5lg3E-1qq0A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qq0 | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 5 | ILE A 161ILE A 167VAL A 144ILE A 133ALA A 137 | None | 0.87A | 5lg3E-1qq0A:undetectable | 5lg3E-1qq0A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qv9 | F420-DEPENDENTMETHYLENETETRAHYDROMETHANOPTERINDEHYDROGENASE (Methanopyruskandleri) |
PF01993(MTD) | 5 | ILE A 9ILE A 68VAL A 38ILE A 59ALA A 60 | None | 1.05A | 5lg3E-1qv9A:3.5 | 5lg3E-1qv9A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvr | CLPB PROTEIN (Thermusthermophilus) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ILE A 704GLU A 668ASP A 667ILE A 669ALA A 672 | None | 1.06A | 5lg3E-1qvrA:2.7 | 5lg3E-1qvrA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut1 | DR HEMAGGLUTININSTRUCTURAL SUBUNIT (Escherichiacoli) |
PF04619(Adhesin_Dr) | 6 | ILE A 112ILE A 85PHE A 70VAL A 44THR A 11ALA A 60 | None | 1.46A | 5lg3E-1ut1A:0.0 | 5lg3E-1ut1A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyv | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF01039(Carboxyl_trans) | 5 | ILE A1619ILE A1803VAL A1584ASP A1796ALA A1518 | None | 0.91A | 5lg3E-1uyvA:undetectable | 5lg3E-1uyvA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz4 | MAN5A (Cellvibriomixtus) |
PF00150(Cellulase) | 5 | ILE A 375VAL A 44GLU A 67ASN A 70ILE A 74 | None | 1.03A | 5lg3E-1uz4A:undetectable | 5lg3E-1uz4A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj7 | BIFUNCTIONALRELA/SPOT (Streptococcusdysgalactiae) |
PF04607(RelA_SpoT)PF13328(HD_4) | 5 | ILE A 322ILE A 268VAL A 315THR A 313ILE A 285 | None | 1.04A | 5lg3E-1vj7A:undetectable | 5lg3E-1vj7A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl0 | DTDP-4-DEHYDRORHAMNOSE REDUCTASE, RFBDORTHOLOG (Clostridiumacetobutylicum) |
PF04321(RmlD_sub_bind) | 5 | ILE A 3ILE A 56VAL A 27ASN A 9ALA A 189 | None | 1.09A | 5lg3E-1vl0A:undetectable | 5lg3E-1vl0A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl8 | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] SUBUNIT A (Pyrococcushorikoshii) |
PF00117(GATase) | 5 | ILE A 106ILE A 108VAL A 124GLU A 177ILE A 178 | None | 1.07A | 5lg3E-1wl8A:undetectable | 5lg3E-1wl8A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7m | ATPPHOSPHORIBOSYLTRANSFERASE (Lactococcuslactis) |
PF01634(HisG) | 5 | PHE E 57VAL E 68THR E 72ASN E 76ILE E 55 | None | 1.08A | 5lg3E-1z7mE:undetectable | 5lg3E-1z7mE:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh8 | OXIDOREDUCTASE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ILE A 257ILE A 259PHE A 136ASN A 235ALA A 194 | None | 0.91A | 5lg3E-1zh8A:undetectable | 5lg3E-1zh8A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zyp | ALKYL HYDROPEROXIDEREDUCTASE SUBUNIT F (Salmonellaenterica) |
PF13192(Thioredoxin_3) | 5 | ILE A 115ILE A 112VAL A 195ILE A 191ALA A 138 | None | 1.11A | 5lg3E-1zypA:undetectable | 5lg3E-1zypA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbn | RIBONUCLEASE Z (Escherichiacoli) |
PF12706(Lactamase_B_2) | 5 | ILE A 209ILE A 22ASN A 304ILE A 267ALA A 297 | None | 1.07A | 5lg3E-2cbnA:undetectable | 5lg3E-2cbnA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dmz | INAD-LIKE PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE A 79ILE A 48VAL A 74ASP A 69ILE A 31 | None | 1.00A | 5lg3E-2dmzA:undetectable | 5lg3E-2dmzA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fko | 173AA LONGHYPOTHETICALFERRIPYOCHELINBINDING PROTEIN (Pyrococcushorikoshii) |
PF00132(Hexapep) | 5 | ILE A 74ILE A 80VAL A 52THR A 35ALA A 41 | None | 1.03A | 5lg3E-2fkoA:undetectable | 5lg3E-2fkoA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggq | 401AA LONGHYPOTHETICALGLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00132(Hexapep)PF00483(NTP_transferase) | 5 | ILE A 306ILE A 317THR A 365ILE A 371ALA A 357 | None | 1.07A | 5lg3E-2ggqA:undetectable | 5lg3E-2ggqA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ILE A 392ILE A 370PHE A 448ASP A 365ILE A 455 | None | 1.09A | 5lg3E-2hckA:undetectable | 5lg3E-2hckA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdw | HYPOTHETICAL PROTEINPA2218 (Pseudomonasaeruginosa) |
PF02129(Peptidase_S15) | 5 | ILE A 101ILE A 99PHE A 125ILE A 359ALA A 360 | None | 1.03A | 5lg3E-2hdwA:undetectable | 5lg3E-2hdwA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxd | DCTP DEAMINASE,DUMP-FORMING (Methanocaldococcusjannaschii) |
PF00692(dUTPase) | 5 | ILE A 42ILE A 59VAL A 96ASP A 38ILE A 65 | None | 0.99A | 5lg3E-2hxdA:undetectable | 5lg3E-2hxdA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lv4 | PUTATIVE OUTERMEMBRANE OR EXPORTEDPROTEIN (Salmonellaenterica) |
PF16583(ZirS_C) | 5 | ILE A 258ILE A 272VAL A 219ASN A 223GLU A 254 | None | 0.87A | 5lg3E-2lv4A:undetectable | 5lg3E-2lv4A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjt | NICOTINAMIDE-NUCLEOTIDEADENYLYLTRANSFERASE (Francisellatularensis) |
no annotation | 5 | ILE B 303ILE B 257VAL B 312GLU B 250ALA B 208 | NoneNoneNone MN B 506 (-2.7A)None | 0.90A | 5lg3E-2qjtB:undetectable | 5lg3E-2qjtB:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbn | TERMINASE LARGESUBUNIT (Bacillus phageSPP1) |
PF17288(Terminase_3C) | 5 | ILE A 288ILE A 363ASN A 399GLU A 376ILE A 373 | None | 1.08A | 5lg3E-2wbnA:undetectable | 5lg3E-2wbnA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wte | CSA3 (Sulfolobussolfataricus) |
no annotation | 5 | ILE A 66ILE A 68VAL A 33THR A 7ILE A 104 | None | 1.08A | 5lg3E-2wteA:undetectable | 5lg3E-2wteA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | ILE A 107PHE A 103ASN A 568GLU A 39ALA A 32 | None | 0.98A | 5lg3E-2x0qA:undetectable | 5lg3E-2x0qA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxd | PROBABLECOBALT-PRECORRIN-6YC(15)-METHYLTRANSFERASE[DECARBOXYLATING] (Methanocaldococcusjannaschii) |
PF13847(Methyltransf_31) | 5 | ILE A 112ILE A 115ASP A 120ILE A 127ALA A 104 | None | 1.04A | 5lg3E-2yxdA:undetectable | 5lg3E-2yxdA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z61 | PROBABLE ASPARTATEAMINOTRANSFERASE 2 (Methanocaldococcusjannaschii) |
PF00155(Aminotran_1_2) | 5 | ILE A 217ILE A 187VAL A 234ASN A 237ILE A 240 | None | 1.04A | 5lg3E-2z61A:undetectable | 5lg3E-2z61A:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1z | HEMOLYMPH JUVENILEHORMONE BINDINGPROTEIN (Bombyx mori) |
PF06585(JHBP) | 5 | ILE A 67PHE A 62THR A 120ILE A 193ALA A 192 | NoneNoneNoneNoneMPD A 232 ( 4.3A) | 1.03A | 5lg3E-3a1zA:undetectable | 5lg3E-3a1zA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3auf | GLYCINAMIDERIBONUCLEOTIDETRANSFORMYLASE 1 (Symbiobacteriumtoebii) |
PF00551(Formyl_trans_N) | 6 | ILE A 4ILE A 182VAL A 6ASN A 14GLU A 174ALA A 17 | None | 1.38A | 5lg3E-3aufA:undetectable | 5lg3E-3aufA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 6 | ILE A 247ILE A 216PHE A 137VAL A 253ASP A 221ILE A 224 | None | 1.31A | 5lg3E-3bmwA:undetectable | 5lg3E-3bmwA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4n | UNCHARACTERIZEDPROTEIN DR_0571 (Deinococcusradiodurans) |
PF01266(DAO) | 5 | ILE A 229VAL A 41GLU A 68ASN A 74ALA A 178 | NoneNoneADP A 411 (-2.3A)ADP A 411 (-3.8A)None | 1.04A | 5lg3E-3c4nA:undetectable | 5lg3E-3c4nA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-ACETYLTRANSFERASE (Enterococcusfaecalis) |
PF00132(Hexapep)PF08503(DapH_N)PF14602(Hexapep_2) | 6 | ILE A 165ILE A 171VAL A 139THR A 125ILE A 127ALA A 131 | None | 0.94A | 5lg3E-3cj8A:undetectable | 5lg3E-3cj8A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cta | RIBOFLAVIN KINASE (Thermoplasmaacidophilum) |
PF01982(CTP-dep_RFKase)PF13545(HTH_Crp_2) | 5 | ILE A 196ILE A 134VAL A 182ASP A 192ILE A 95 | None | 1.06A | 5lg3E-3ctaA:undetectable | 5lg3E-3ctaA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfz | PRECORRIN-2DEHYDROGENASE (Bacillusmegaterium) |
PF13241(NAD_binding_7)PF14824(Sirohm_synth_M) | 5 | ILE A 36ILE A 26VAL A 13ASN A 98ALA A 77 | None | 0.90A | 5lg3E-3dfzA:undetectable | 5lg3E-3dfzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fw2 | THIOL-DISULFIDEOXIDOREDUCTASE (Bacteroidesthetaiotaomicron) |
PF13905(Thioredoxin_8) | 5 | ILE A 248ILE A 285ASN A 255ILE A 324ALA A 319 | None | 1.03A | 5lg3E-3fw2A:undetectable | 5lg3E-3fw2A:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbr | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Sulfolobussolfataricus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | ILE A 214VAL A 216THR A 231ASN A 247ASP A 250 | None | 1.05A | 5lg3E-3gbrA:undetectable | 5lg3E-3gbrA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbr | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Sulfolobussolfataricus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | VAL A 216THR A 231ASN A 247ASP A 250ALA A 293 | None | 0.94A | 5lg3E-3gbrA:undetectable | 5lg3E-3gbrA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASEFAD-SUBUNIT (Eubacteriumbarkeri) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | ILE C 86ILE C 71VAL C 90ASN C 67ALA C 133 | None | 1.04A | 5lg3E-3hrdC:2.2 | 5lg3E-3hrdC:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ht4 | ALUMINUM RESISTANCEPROTEIN (Bacillus cereus) |
PF06838(Met_gamma_lyase) | 5 | ILE A 198PHE A 194VAL A 202THR A 166GLU A 109 | None | 1.11A | 5lg3E-3ht4A:undetectable | 5lg3E-3ht4A:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3a | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Leptospirainterrogans) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 39ILE A 45VAL A 21ILE A 9ALA A 13 | None | 1.02A | 5lg3E-3i3aA:undetectable | 5lg3E-3i3aA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 5 | ILE A 195PHE A 188VAL A 168ILE A 207ALA A 173 | NoneNoneNoneFAD A 541 (-4.4A)None | 1.09A | 5lg3E-3js8A:undetectable | 5lg3E-3js8A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwp | TRANSCRIPTIONALREGULATORY PROTEINSIR2 HOMOLOGUE (Plasmodiumfalciparum) |
PF02146(SIR2) | 5 | ILE A 121VAL A 104ASN A 209ILE A 189ALA A 190 | None | 0.91A | 5lg3E-3jwpA:undetectable | 5lg3E-3jwpA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2q | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Marinobacterhydrocarbonoclasticus) |
PF00365(PFK) | 5 | ILE A 215VAL A 244THR A 167ILE A 163ALA A 160 | None | 1.00A | 5lg3E-3k2qA:undetectable | 5lg3E-3k2qA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lij | CALCIUM/CALMODULINDEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 5 | ILE A 165ILE A 164PHE A 156ASN A 189GLU A 188 | NoneNoneNone MG A 521 ( 2.9A)None | 1.09A | 5lg3E-3lijA:undetectable | 5lg3E-3lijA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqg | LIPOPOLYSACCHARIDESBIOSYNTHESISACETYLTRANSFERASE (Bordetellapetrii) |
PF00132(Hexapep) | 5 | ILE A 28ILE A 22VAL A 46ASN A 61ILE A 58 | None | 0.98A | 5lg3E-3mqgA:undetectable | 5lg3E-3mqgA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwp | 6-PHOSPHOGLUCONOLACTONASE (Shewanellabaltica) |
PF01182(Glucosamine_iso) | 5 | ILE A 188PHE A 129VAL A 218ASP A 71ALA A 181 | None | 1.11A | 5lg3E-3nwpA:undetectable | 5lg3E-3nwpA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o03 | DEHYDROGENASE WITHDIFFERENTSPECIFICITIES (Streptococcussuis) |
PF13561(adh_short_C2) | 5 | ILE A 148ILE A 191THR A 174ASN A 251ILE A 254 | NAP A 273 (-4.2A)NoneNoneNoneNone | 1.11A | 5lg3E-3o03A:undetectable | 5lg3E-3o03A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6c | PYRIDOXINE5'-PHOSPHATESYNTHASE (Campylobacterjejuni) |
PF03740(PdxJ) | 5 | ILE A 38VAL A 31ASP A 23ILE A 10ALA A 11 | None | 1.05A | 5lg3E-3o6cA:undetectable | 5lg3E-3o6cA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 355ILE A 331PHE A 321ILE A 387ALA A 343 | None | 0.87A | 5lg3E-3oneA:undetectable | 5lg3E-3oneA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otm | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 5 | ILE A 161ILE A 167THR A 131ILE A 133ALA A 137 | None | 0.86A | 5lg3E-3otmA:undetectable | 5lg3E-3otmA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otm | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 5 | ILE A 161ILE A 167VAL A 144ILE A 133ALA A 137 | None | 0.87A | 5lg3E-3otmA:undetectable | 5lg3E-3otmA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8k | HYDROLASE,CARBON-NITROGENFAMILY (Staphylococcusaureus) |
PF00795(CN_hydrolase) | 5 | ILE A 196ILE A 165VAL A 215ASN A 219GLU A 241 | None | 1.01A | 5lg3E-3p8kA:undetectable | 5lg3E-3p8kA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 40ILE A 34VAL A 58ASN A 86ILE A 83 | None | 1.10A | 5lg3E-3r0sA:undetectable | 5lg3E-3r0sA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 95ILE A 108VAL A 64THR A 50ILE A 52 | None | 0.93A | 5lg3E-3r0sA:undetectable | 5lg3E-3r0sA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | ILE A 372ILE A 332VAL A 408ILE A 382ALA A 296 | None | 0.82A | 5lg3E-3r5gA:2.2 | 5lg3E-3r5gA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 1 (Bos taurus) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF08282(Hydrolase_3)PF13246(Cation_ATPase) | 5 | ILE A 621ILE A 686VAL A 347THR A 697GLU A 714 | None | 1.01A | 5lg3E-3tlmA:0.8 | 5lg3E-3tlmA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uvj | GUANYLATE CYCLASESOLUBLE SUBUNITALPHA-3 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ILE A 571ILE A 487PHE A 490VAL A 563ASN A 507 | None | 1.08A | 5lg3E-3uvjA:undetectable | 5lg3E-3uvjA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2h | D-BETA-HYDROXYBUTYRATE DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ILE A 181ILE A 136VAL A 249ILE A 244ALA A 241 | None | 1.07A | 5lg3E-3v2hA:undetectable | 5lg3E-3v2hA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX IIIRON-SULFUR SUBUNITOF SUCCINATEDEHYDROGENASE (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF13085(Fer2_3)PF13534(Fer4_17) | 5 | ILE B 132ILE A 538VAL B 136THR B 84ASP A 534 | None | 1.01A | 5lg3E-3vrbB:undetectable | 5lg3E-3vrbB:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsc | PROTEIN CYSO (Aeropyrumpernix) |
PF00291(PALP) | 5 | ILE A 135ILE A 134VAL A 163ASN A 155ALA A 233 | NoneNoneNonePLP A 401 ( 3.7A)None | 1.10A | 5lg3E-3vscA:undetectable | 5lg3E-3vscA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a42 | ALPHA-N-ACETYLGLUCOSAMINIDASE FAMILYPROTEIN (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 5 | ILE A1547ILE A1618PHE A1539ASP A1551ILE A1564 | None | 1.06A | 5lg3E-4a42A:undetectable | 5lg3E-4a42A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ILE A 323ILE A 322VAL A 292ILE A 305ALA A 308 | None | 1.04A | 5lg3E-4c13A:undetectable | 5lg3E-4c13A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | ILE A 801VAL A 888THR A 886ILE A 815ALA A 907 | None | 0.87A | 5lg3E-4cakA:1.9 | 5lg3E-4cakA:16.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 69VAL A 47ASP A 250ILE A 338ALA A 296 | NoneNoneMOA A 702 (-3.2A)NoneNone | 1.11A | 5lg3E-4fxsA:undetectable | 5lg3E-4fxsA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gaa | MGC78867 PROTEIN (Xenopus laevis) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | ILE A 257ILE A 217VAL A 275THR A 273ILE A 290 | None | 1.04A | 5lg3E-4gaaA:4.3 | 5lg3E-4gaaA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfg | PUTATIVEACYLTRANSFERASE (Clostridioidesdifficile) |
PF00132(Hexapep) | 5 | ILE A 57ILE A 51VAL A 77ASN A 91ILE A 88 | None | 1.07A | 5lg3E-4mfgA:undetectable | 5lg3E-4mfgA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz0 | CURL (Mooreaproducens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 460ILE A 298VAL A 398ILE A 279ALA A 233 | None | 0.95A | 5lg3E-4mz0A:undetectable | 5lg3E-4mz0A:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqq | DEOXYRIBONUCLEOSIDEREGULATOR (Bacillussubtilis) |
PF04198(Sugar-bind) | 5 | PHE A 207THR A 105GLU A 272ILE A 204ALA A 205 | None | 1.03A | 5lg3E-4oqqA:undetectable | 5lg3E-4oqqA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ILE A 79ILE A 48VAL A 396THR A 405ILE A 407 | None | 0.97A | 5lg3E-4oyaA:undetectable | 5lg3E-4oyaA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 5 | ILE A 117VAL A 122THR A 125ASN A 129ILE A 160 | None | 1.10A | 5lg3E-4s3jA:undetectable | 5lg3E-4s3jA:22.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 5 | ILE A 20ILE A 23ASP A 158ILE A 162ALA A 197 | None | 0.72A | 5lg3E-4twfA:32.6 | 5lg3E-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126ASN A 154ASP A 158ALA A 197 | None | 0.62A | 5lg3E-4twfA:32.6 | 5lg3E-4twfA:99.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgk | NEUTRAL CERAMIDASE (Homo sapiens) |
PF04734(Ceramidase_alk)PF17048(Ceramidse_alk_C) | 5 | ILE A 534VAL A 568THR A 566ASN A 564ILE A 245 | None | 1.09A | 5lg3E-4wgkA:undetectable | 5lg3E-4wgkA:18.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126ASN A 154ILE A 162ALA A 197 | None | 0.81A | 5lg3E-4yeuA:29.5 | 5lg3E-4yeuA:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 7 | ILE A 20ILE A 23PHE A 126VAL A 147ASN A 154ASP A 158ALA A 197 | None | 1.06A | 5lg3E-4yeuA:29.5 | 5lg3E-4yeuA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | ILE A 826VAL A 842THR A 840ILE A 758ALA A 815 | None | 1.05A | 5lg3E-4ypjA:3.4 | 5lg3E-4ypjA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 5 | ILE A1619ILE A1803VAL A1584ASP A1796ALA A1518 | None | 1.00A | 5lg3E-5cslA:undetectable | 5lg3E-5cslA:8.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fi5 | TETRAHYDROALSTONINESYNTHASE (Catharanthusroseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 326ILE A 349VAL A 329GLU A 77ALA A 133 | NoneNoneNone ZN A 402 (-3.0A)None | 1.00A | 5lg3E-5fi5A:undetectable | 5lg3E-5fi5A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ILE A 712ILE A 390THR A 13ASN A1034ALA A 9 | None | 1.08A | 5lg3E-5fqdA:undetectable | 5lg3E-5fqdA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g6r | IMINE REDUCTASE (Aspergillusoryzae) |
PF03446(NAD_binding_2) | 5 | ILE A 63ILE A 5VAL A 89THR A 87ILE A 145 | None | 1.07A | 5lg3E-5g6rA:undetectable | 5lg3E-5g6rA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gje | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 6 (Homo sapiens) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 5 | ILE B1167VAL B1181ASN B1155GLU B1154ILE B 949 | None | 1.02A | 5lg3E-5gjeB:undetectable | 5lg3E-5gjeB:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hd2 | PARASPORAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | ILE A 183VAL A 254THR A 94ASN A 137GLU A 113 | None | 1.10A | 5lg3E-5hd2A:undetectable | 5lg3E-5hd2A:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy7 | PUTATIVE PRE-MRNASPLICING PROTEINYSF3 (Chaetomiumthermophilum) |
PF03178(CPSF_A)PF10433(MMS1_N)no annotation | 5 | ILE A 446VAL A 428ASN D 58ASP A 815ALA A 884 | None | 1.05A | 5lg3E-5hy7A:undetectable | 5lg3E-5hy7A:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6g | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | ILE A1664ILE A1843VAL A1629ASP A1836ALA A1556 | None | 1.04A | 5lg3E-5i6gA:undetectable | 5lg3E-5i6gA:14.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6h | ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | ILE A1664ILE A1843VAL A1629ASP A1836ALA A1556 | None | 1.06A | 5lg3E-5i6hA:undetectable | 5lg3E-5i6hA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxx | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Moraxellacatarrhalis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 45ILE A 51VAL A 27ILE A 15ALA A 19 | None | 0.86A | 5lg3E-5jxxA:undetectable | 5lg3E-5jxxA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9h | 0940_GH29 (unidentified) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 5 | ILE A 302ILE A 308PHE A 300ILE A 70ALA A 24 | None | 0.93A | 5lg3E-5k9hA:undetectable | 5lg3E-5k9hA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 5 | ILE A 466ILE A 568PHE A 492ASN A 607ALA A 535 | None | 0.82A | 5lg3E-5mqsA:undetectable | 5lg3E-5mqsA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (Methanotorrisformicicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | ILE B 175ILE B 160VAL B 48ASN B 55GLU B 54 | None | 1.10A | 5lg3E-5n28B:undetectable | 5lg3E-5n28B:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ILE A 39ILE A 44VAL A 230ILE A 82ALA A 83 | None | 0.98A | 5lg3E-5n9xA:undetectable | 5lg3E-5n9xA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | ILE A2680ILE A2666VAL A2679THR A2626GLU A3006 | None | 1.06A | 5lg3E-5nugA:undetectable | 5lg3E-5nugA:5.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2w | SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | ILE A 240VAL A 183THR A 139ILE A 22ALA A 21 | NoneNoneNAP A 301 ( 3.8A)NoneNone | 1.06A | 5lg3E-5u2wA:undetectable | 5lg3E-5u2wA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkq | NO MECHANORECEPTORPOTENTIAL C ISOFORML (Drosophilamelanogaster) |
PF00023(Ank)PF00520(Ion_trans)PF12796(Ank_2)PF13637(Ank_4) | 5 | ILE A 797PHE A 812VAL A 842ASN A 803ALA A 768 | None | 0.99A | 5lg3E-5vkqA:undetectable | 5lg3E-5vkqA:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyw | PYRUVATE CARBOXYLASE (Lactococcuslactis) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 338VAL A 404ASN A 432ASN A 428ALA A 440 | None | 1.08A | 5lg3E-5vywA:undetectable | 5lg3E-5vywA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 5 | ILE A 206ILE A 194ASP A 114ILE A 102ALA A 236 | NoneNoneEDO A 506 (-3.4A)NoneNone | 1.07A | 5lg3E-6gu8A:undetectable | 5lg3E-6gu8A:undetectable |