SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_E_Z80E401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE


(Candida
albicans)
PF00150
(Cellulase)
5 ILE A  15
VAL A 289
ASN A 191
ASP A 133
ILE A 224
None
None
CTS  A 401 (-3.1A)
None
None
1.00A 5lg3E-1eqcA:
0.0
5lg3E-1eqcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2a HYDROGENASE

(Desulfovibrio
vulgaris)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 ILE S  71
THR S 160
ASN S 156
ILE S 145
ALA S 144
None
1.11A 5lg3E-1h2aS:
0.0
5lg3E-1h2aS:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE O  93
PHE O  91
ASN O  22
ILE O  25
ALA O   1
None
1.05A 5lg3E-1hdgO:
undetectable
5lg3E-1hdgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2


(Mus musculus)
PF00061
(Lipocalin)
5 ILE A  15
ILE A  45
VAL A  12
GLU A  49
ALA A  71
None
1.08A 5lg3E-1jv4A:
undetectable
5lg3E-1jv4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger)
PF00295
(Glyco_hydro_28)
5 ILE A 190
ILE A 210
PHE A 220
VAL A 160
ALA A 201
None
0.71A 5lg3E-1nhcA:
undetectable
5lg3E-1nhcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
THR A 131
ILE A 133
ALA A 137
None
0.85A 5lg3E-1qq0A:
undetectable
5lg3E-1qq0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
VAL A 144
ILE A 133
ALA A 137
None
0.87A 5lg3E-1qq0A:
undetectable
5lg3E-1qq0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE


(Methanopyrus
kandleri)
PF01993
(MTD)
5 ILE A   9
ILE A  68
VAL A  38
ILE A  59
ALA A  60
None
1.05A 5lg3E-1qv9A:
3.5
5lg3E-1qv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
5 ILE A 704
GLU A 668
ASP A 667
ILE A 669
ALA A 672
None
1.06A 5lg3E-1qvrA:
2.7
5lg3E-1qvrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut1 DR HEMAGGLUTININ
STRUCTURAL SUBUNIT


(Escherichia
coli)
PF04619
(Adhesin_Dr)
6 ILE A 112
ILE A  85
PHE A  70
VAL A  44
THR A  11
ALA A  60
None
1.46A 5lg3E-1ut1A:
0.0
5lg3E-1ut1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF01039
(Carboxyl_trans)
5 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
None
0.91A 5lg3E-1uyvA:
undetectable
5lg3E-1uyvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus)
PF00150
(Cellulase)
5 ILE A 375
VAL A  44
GLU A  67
ASN A  70
ILE A  74
None
1.03A 5lg3E-1uz4A:
undetectable
5lg3E-1uz4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT


(Streptococcus
dysgalactiae)
PF04607
(RelA_SpoT)
PF13328
(HD_4)
5 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
None
1.04A 5lg3E-1vj7A:
undetectable
5lg3E-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG


(Clostridium
acetobutylicum)
PF04321
(RmlD_sub_bind)
5 ILE A   3
ILE A  56
VAL A  27
ASN A   9
ALA A 189
None
1.09A 5lg3E-1vl0A:
undetectable
5lg3E-1vl0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A


(Pyrococcus
horikoshii)
PF00117
(GATase)
5 ILE A 106
ILE A 108
VAL A 124
GLU A 177
ILE A 178
None
1.07A 5lg3E-1wl8A:
undetectable
5lg3E-1wl8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Lactococcus
lactis)
PF01634
(HisG)
5 PHE E  57
VAL E  68
THR E  72
ASN E  76
ILE E  55
None
1.08A 5lg3E-1z7mE:
undetectable
5lg3E-1z7mE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ILE A 257
ILE A 259
PHE A 136
ASN A 235
ALA A 194
None
0.91A 5lg3E-1zh8A:
undetectable
5lg3E-1zh8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F


(Salmonella
enterica)
PF13192
(Thioredoxin_3)
5 ILE A 115
ILE A 112
VAL A 195
ILE A 191
ALA A 138
None
1.11A 5lg3E-1zypA:
undetectable
5lg3E-1zypA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli)
PF12706
(Lactamase_B_2)
5 ILE A 209
ILE A  22
ASN A 304
ILE A 267
ALA A 297
None
1.07A 5lg3E-2cbnA:
undetectable
5lg3E-2cbnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmz INAD-LIKE PROTEIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE A  79
ILE A  48
VAL A  74
ASP A  69
ILE A  31
None
1.00A 5lg3E-2dmzA:
undetectable
5lg3E-2dmzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00132
(Hexapep)
5 ILE A  74
ILE A  80
VAL A  52
THR A  35
ALA A  41
None
1.03A 5lg3E-2fkoA:
undetectable
5lg3E-2fkoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ILE A 306
ILE A 317
THR A 365
ILE A 371
ALA A 357
None
1.07A 5lg3E-2ggqA:
undetectable
5lg3E-2ggqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ILE A 392
ILE A 370
PHE A 448
ASP A 365
ILE A 455
None
1.09A 5lg3E-2hckA:
undetectable
5lg3E-2hckA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218


(Pseudomonas
aeruginosa)
PF02129
(Peptidase_S15)
5 ILE A 101
ILE A  99
PHE A 125
ILE A 359
ALA A 360
None
1.03A 5lg3E-2hdwA:
undetectable
5lg3E-2hdwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING


(Methanocaldococcus
jannaschii)
PF00692
(dUTPase)
5 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
None
0.99A 5lg3E-2hxdA:
undetectable
5lg3E-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv4 PUTATIVE OUTER
MEMBRANE OR EXPORTED
PROTEIN


(Salmonella
enterica)
PF16583
(ZirS_C)
5 ILE A 258
ILE A 272
VAL A 219
ASN A 223
GLU A 254
None
0.87A 5lg3E-2lv4A:
undetectable
5lg3E-2lv4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE


(Francisella
tularensis)
no annotation 5 ILE B 303
ILE B 257
VAL B 312
GLU B 250
ALA B 208
None
None
None
MN  B 506 (-2.7A)
None
0.90A 5lg3E-2qjtB:
undetectable
5lg3E-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT


(Bacillus phage
SPP1)
PF17288
(Terminase_3C)
5 ILE A 288
ILE A 363
ASN A 399
GLU A 376
ILE A 373
None
1.08A 5lg3E-2wbnA:
undetectable
5lg3E-2wbnA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus)
no annotation 5 ILE A  66
ILE A  68
VAL A  33
THR A   7
ILE A 104
None
1.08A 5lg3E-2wteA:
undetectable
5lg3E-2wteA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
5 ILE A 107
PHE A 103
ASN A 568
GLU A  39
ALA A  32
None
0.98A 5lg3E-2x0qA:
undetectable
5lg3E-2x0qA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]


(Methanocaldococcus
jannaschii)
PF13847
(Methyltransf_31)
5 ILE A 112
ILE A 115
ASP A 120
ILE A 127
ALA A 104
None
1.04A 5lg3E-2yxdA:
undetectable
5lg3E-2yxdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2


(Methanocaldococcus
jannaschii)
PF00155
(Aminotran_1_2)
5 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
None
1.04A 5lg3E-2z61A:
undetectable
5lg3E-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN


(Bombyx mori)
PF06585
(JHBP)
5 ILE A  67
PHE A  62
THR A 120
ILE A 193
ALA A 192
None
None
None
None
MPD  A 232 ( 4.3A)
1.03A 5lg3E-3a1zA:
undetectable
5lg3E-3a1zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1


(Symbiobacterium
toebii)
PF00551
(Formyl_trans_N)
6 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
ALA A  17
None
1.38A 5lg3E-3aufA:
undetectable
5lg3E-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
6 ILE A 247
ILE A 216
PHE A 137
VAL A 253
ASP A 221
ILE A 224
None
1.31A 5lg3E-3bmwA:
undetectable
5lg3E-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571


(Deinococcus
radiodurans)
PF01266
(DAO)
5 ILE A 229
VAL A  41
GLU A  68
ASN A  74
ALA A 178
None
None
ADP  A 411 (-2.3A)
ADP  A 411 (-3.8A)
None
1.04A 5lg3E-3c4nA:
undetectable
5lg3E-3c4nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE


(Enterococcus
faecalis)
PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2)
6 ILE A 165
ILE A 171
VAL A 139
THR A 125
ILE A 127
ALA A 131
None
0.94A 5lg3E-3cj8A:
undetectable
5lg3E-3cj8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cta RIBOFLAVIN KINASE

(Thermoplasma
acidophilum)
PF01982
(CTP-dep_RFKase)
PF13545
(HTH_Crp_2)
5 ILE A 196
ILE A 134
VAL A 182
ASP A 192
ILE A  95
None
1.06A 5lg3E-3ctaA:
undetectable
5lg3E-3ctaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfz PRECORRIN-2
DEHYDROGENASE


(Bacillus
megaterium)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M)
5 ILE A  36
ILE A  26
VAL A  13
ASN A  98
ALA A  77
None
0.90A 5lg3E-3dfzA:
undetectable
5lg3E-3dfzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw2 THIOL-DISULFIDE
OXIDOREDUCTASE


(Bacteroides
thetaiotaomicron)
PF13905
(Thioredoxin_8)
5 ILE A 248
ILE A 285
ASN A 255
ILE A 324
ALA A 319
None
1.03A 5lg3E-3fw2A:
undetectable
5lg3E-3fw2A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 ILE A 214
VAL A 216
THR A 231
ASN A 247
ASP A 250
None
1.05A 5lg3E-3gbrA:
undetectable
5lg3E-3gbrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 VAL A 216
THR A 231
ASN A 247
ASP A 250
ALA A 293
None
0.94A 5lg3E-3gbrA:
undetectable
5lg3E-3gbrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT


(Eubacterium
barkeri)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 ILE C  86
ILE C  71
VAL C  90
ASN C  67
ALA C 133
None
1.04A 5lg3E-3hrdC:
2.2
5lg3E-3hrdC:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN


(Bacillus cereus)
PF06838
(Met_gamma_lyase)
5 ILE A 198
PHE A 194
VAL A 202
THR A 166
GLU A 109
None
1.11A 5lg3E-3ht4A:
undetectable
5lg3E-3ht4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Leptospira
interrogans)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  39
ILE A  45
VAL A  21
ILE A   9
ALA A  13
None
1.02A 5lg3E-3i3aA:
undetectable
5lg3E-3i3aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 ILE A 195
PHE A 188
VAL A 168
ILE A 207
ALA A 173
None
None
None
FAD  A 541 (-4.4A)
None
1.09A 5lg3E-3js8A:
undetectable
5lg3E-3js8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwp TRANSCRIPTIONAL
REGULATORY PROTEIN
SIR2 HOMOLOGUE


(Plasmodium
falciparum)
PF02146
(SIR2)
5 ILE A 121
VAL A 104
ASN A 209
ILE A 189
ALA A 190
None
0.91A 5lg3E-3jwpA:
undetectable
5lg3E-3jwpA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Marinobacter
hydrocarbonoclasticus)
PF00365
(PFK)
5 ILE A 215
VAL A 244
THR A 167
ILE A 163
ALA A 160
None
1.00A 5lg3E-3k2qA:
undetectable
5lg3E-3k2qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 ILE A 165
ILE A 164
PHE A 156
ASN A 189
GLU A 188
None
None
None
MG  A 521 ( 2.9A)
None
1.09A 5lg3E-3lijA:
undetectable
5lg3E-3lijA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE


(Bordetella
petrii)
PF00132
(Hexapep)
5 ILE A  28
ILE A  22
VAL A  46
ASN A  61
ILE A  58
None
0.98A 5lg3E-3mqgA:
undetectable
5lg3E-3mqgA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE


(Shewanella
baltica)
PF01182
(Glucosamine_iso)
5 ILE A 188
PHE A 129
VAL A 218
ASP A  71
ALA A 181
None
1.11A 5lg3E-3nwpA:
undetectable
5lg3E-3nwpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES


(Streptococcus
suis)
PF13561
(adh_short_C2)
5 ILE A 148
ILE A 191
THR A 174
ASN A 251
ILE A 254
NAP  A 273 (-4.2A)
None
None
None
None
1.11A 5lg3E-3o03A:
undetectable
5lg3E-3o03A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Campylobacter
jejuni)
PF03740
(PdxJ)
5 ILE A  38
VAL A  31
ASP A  23
ILE A  10
ALA A  11
None
1.05A 5lg3E-3o6cA:
undetectable
5lg3E-3o6cA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 355
ILE A 331
PHE A 321
ILE A 387
ALA A 343
None
0.87A 5lg3E-3oneA:
undetectable
5lg3E-3oneA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
THR A 131
ILE A 133
ALA A 137
None
0.86A 5lg3E-3otmA:
undetectable
5lg3E-3otmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
VAL A 144
ILE A 133
ALA A 137
None
0.87A 5lg3E-3otmA:
undetectable
5lg3E-3otmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY


(Staphylococcus
aureus)
PF00795
(CN_hydrolase)
5 ILE A 196
ILE A 165
VAL A 215
ASN A 219
GLU A 241
None
1.01A 5lg3E-3p8kA:
undetectable
5lg3E-3p8kA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  40
ILE A  34
VAL A  58
ASN A  86
ILE A  83
None
1.10A 5lg3E-3r0sA:
undetectable
5lg3E-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  95
ILE A 108
VAL A  64
THR A  50
ILE A  52
None
0.93A 5lg3E-3r0sA:
undetectable
5lg3E-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa)
PF00211
(Guanylate_cyc)
5 ILE A 372
ILE A 332
VAL A 408
ILE A 382
ALA A 296
None
0.82A 5lg3E-3r5gA:
2.2
5lg3E-3r5gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1


(Bos taurus)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase)
5 ILE A 621
ILE A 686
VAL A 347
THR A 697
GLU A 714
None
1.01A 5lg3E-3tlmA:
0.8
5lg3E-3tlmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
1.08A 5lg3E-3uvjA:
undetectable
5lg3E-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 ILE A 181
ILE A 136
VAL A 249
ILE A 244
ALA A 241
None
1.07A 5lg3E-3v2hA:
undetectable
5lg3E-3v2hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
None
1.01A 5lg3E-3vrbB:
undetectable
5lg3E-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix)
PF00291
(PALP)
5 ILE A 135
ILE A 134
VAL A 163
ASN A 155
ALA A 233
None
None
None
PLP  A 401 ( 3.7A)
None
1.10A 5lg3E-3vscA:
undetectable
5lg3E-3vscA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a42 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
5 ILE A1547
ILE A1618
PHE A1539
ASP A1551
ILE A1564
None
1.06A 5lg3E-4a42A:
undetectable
5lg3E-4a42A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE


(Staphylococcus
aureus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ILE A 323
ILE A 322
VAL A 292
ILE A 305
ALA A 308
None
1.04A 5lg3E-4c13A:
undetectable
5lg3E-4c13A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 ILE A 801
VAL A 888
THR A 886
ILE A 815
ALA A 907
None
0.87A 5lg3E-4cakA:
1.9
5lg3E-4cakA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A  69
VAL A  47
ASP A 250
ILE A 338
ALA A 296
None
None
MOA  A 702 (-3.2A)
None
None
1.11A 5lg3E-4fxsA:
undetectable
5lg3E-4fxsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
None
1.04A 5lg3E-4gaaA:
4.3
5lg3E-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfg PUTATIVE
ACYLTRANSFERASE


(Clostridioides
difficile)
PF00132
(Hexapep)
5 ILE A  57
ILE A  51
VAL A  77
ASN A  91
ILE A  88
None
1.07A 5lg3E-4mfgA:
undetectable
5lg3E-4mfgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 460
ILE A 298
VAL A 398
ILE A 279
ALA A 233
None
0.95A 5lg3E-4mz0A:
undetectable
5lg3E-4mz0A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR


(Bacillus
subtilis)
PF04198
(Sugar-bind)
5 PHE A 207
THR A 105
GLU A 272
ILE A 204
ALA A 205
None
1.03A 5lg3E-4oqqA:
undetectable
5lg3E-4oqqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.97A 5lg3E-4oyaA:
undetectable
5lg3E-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
5 ILE A 117
VAL A 122
THR A 125
ASN A 129
ILE A 160
None
1.10A 5lg3E-4s3jA:
undetectable
5lg3E-4s3jA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
ASP A 158
ILE A 162
ALA A 197
None
0.72A 5lg3E-4twfA:
32.6
5lg3E-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
ASN A 154
ASP A 158
ALA A 197
None
0.62A 5lg3E-4twfA:
32.6
5lg3E-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens)
PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C)
5 ILE A 534
VAL A 568
THR A 566
ASN A 564
ILE A 245
None
1.09A 5lg3E-4wgkA:
undetectable
5lg3E-4wgkA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
ASN A 154
ILE A 162
ALA A 197
None
0.81A 5lg3E-4yeuA:
29.5
5lg3E-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
7 ILE A  20
ILE A  23
PHE A 126
VAL A 147
ASN A 154
ASP A 158
ALA A 197
None
1.06A 5lg3E-4yeuA:
29.5
5lg3E-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 ILE A 826
VAL A 842
THR A 840
ILE A 758
ALA A 815
None
1.05A 5lg3E-4ypjA:
3.4
5lg3E-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
5 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
None
1.00A 5lg3E-5cslA:
undetectable
5lg3E-5cslA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE


(Catharanthus
roseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 326
ILE A 349
VAL A 329
GLU A  77
ALA A 133
None
None
None
ZN  A 402 (-3.0A)
None
1.00A 5lg3E-5fi5A:
undetectable
5lg3E-5fi5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ILE A 712
ILE A 390
THR A  13
ASN A1034
ALA A   9
None
1.08A 5lg3E-5fqdA:
undetectable
5lg3E-5fqdA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae)
PF03446
(NAD_binding_2)
5 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
None
1.07A 5lg3E-5g6rA:
undetectable
5lg3E-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 ILE B1167
VAL B1181
ASN B1155
GLU B1154
ILE B 949
None
1.02A 5lg3E-5gjeB:
undetectable
5lg3E-5gjeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
None
1.10A 5lg3E-5hd2A:
undetectable
5lg3E-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN
YSF3


(Chaetomium
thermophilum)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
no annotation
5 ILE A 446
VAL A 428
ASN D  58
ASP A 815
ALA A 884
None
1.05A 5lg3E-5hy7A:
undetectable
5lg3E-5hy7A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 ILE A1664
ILE A1843
VAL A1629
ASP A1836
ALA A1556
None
1.04A 5lg3E-5i6gA:
undetectable
5lg3E-5i6gA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 ILE A1664
ILE A1843
VAL A1629
ASP A1836
ALA A1556
None
1.06A 5lg3E-5i6hA:
undetectable
5lg3E-5i6hA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxx ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Moraxella
catarrhalis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  45
ILE A  51
VAL A  27
ILE A  15
ALA A  19
None
0.86A 5lg3E-5jxxA:
undetectable
5lg3E-5jxxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
5 ILE A 302
ILE A 308
PHE A 300
ILE A  70
ALA A  24
None
0.93A 5lg3E-5k9hA:
undetectable
5lg3E-5k9hA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
5 ILE A 466
ILE A 568
PHE A 492
ASN A 607
ALA A 535
None
0.82A 5lg3E-5mqsA:
undetectable
5lg3E-5mqsA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(Methanotorris
formicicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 ILE B 175
ILE B 160
VAL B  48
ASN B  55
GLU B  54
None
1.10A 5lg3E-5n28B:
undetectable
5lg3E-5n28B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A  39
ILE A  44
VAL A 230
ILE A  82
ALA A  83
None
0.98A 5lg3E-5n9xA:
undetectable
5lg3E-5n9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 ILE A2680
ILE A2666
VAL A2679
THR A2626
GLU A3006
None
1.06A 5lg3E-5nugA:
undetectable
5lg3E-5nugA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00106
(adh_short)
5 ILE A 240
VAL A 183
THR A 139
ILE A  22
ALA A  21
None
None
NAP  A 301 ( 3.8A)
None
None
1.06A 5lg3E-5u2wA:
undetectable
5lg3E-5u2wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L


(Drosophila
melanogaster)
PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 ILE A 797
PHE A 812
VAL A 842
ASN A 803
ALA A 768
None
0.99A 5lg3E-5vkqA:
undetectable
5lg3E-5vkqA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 338
VAL A 404
ASN A 432
ASN A 428
ALA A 440
None
1.08A 5lg3E-5vywA:
undetectable
5lg3E-5vywA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-)
no annotation 5 ILE A 206
ILE A 194
ASP A 114
ILE A 102
ALA A 236
None
None
EDO  A 506 (-3.4A)
None
None
1.07A 5lg3E-6gu8A:
undetectable
5lg3E-6gu8A:
undetectable