SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_A_Z80A401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4e | FLAVOCYTOCHROME CFUMARATE REDUCTASE (Shewanellaoneidensis) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | ILE A 131VAL A 277ASP A 270ILE A 303ALA A 305 | FAD A 600 ( 4.7A)FAD A 600 (-4.2A)NoneNoneNone | 1.07A | 5lg3A-1d4eA:undetectable | 5lg3A-1d4eA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fui | L-FUCOSE ISOMERASE (Escherichiacoli) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 5 | ILE A 107ILE A 97THR A 83ASP A 100ALA A 68 | None | 1.08A | 5lg3A-1fuiA:0.0 | 5lg3A-1fuiA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gy9 | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Escherichiacoli) |
PF02668(TauD) | 5 | PHE A 46ASP A 249TRP A 128ILE A 247ALA A 246 | None | 1.04A | 5lg3A-1gy9A:0.0 | 5lg3A-1gy9A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hdg | HOLO-D-GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE (Thermotogamaritima) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ILE O 93PHE O 91ASN O 22ILE O 25ALA O 1 | None | 1.06A | 5lg3A-1hdgO:0.1 | 5lg3A-1hdgO:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idj | PECTIN LYASE A (Aspergillusniger) |
PF00544(Pec_lyase_C) | 5 | VAL A 101ASP A 79TRP A 81ILE A 76ALA A 75 | None | 1.14A | 5lg3A-1idjA:0.0 | 5lg3A-1idjA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nhc | POLYGALACTURONASE I (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 5 | ILE A 190ILE A 210PHE A 220VAL A 160ALA A 201 | None | 0.67A | 5lg3A-1nhcA:undetectable | 5lg3A-1nhcA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oij | PUTATIVEALKYLSULFATASE ATSK (Pseudomonasputida) |
PF02668(TauD) | 5 | PHE C 56ASP C 258TRP C 137ILE C 256ALA C 255 | None | 1.12A | 5lg3A-1oijC:0.0 | 5lg3A-1oijC:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pk8 | RAT SYNAPSIN I (Rattusnorvegicus) |
PF02078(Synapsin)PF02750(Synapsin_C) | 5 | ILE A 308VAL A 267GLU A 373ASP A 313ILE A 385 | ATP A 800 (-4.1A)ATP A 800 (-4.3A) CA A 817 ( 2.2A)ATP A 800 (-3.6A)ATP A 800 ( 4.5A) | 1.15A | 5lg3A-1pk8A:0.0 | 5lg3A-1pk8A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qq0 | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 6 | ILE A 161ILE A 167VAL A 144THR A 131ILE A 133ALA A 137 | None | 0.97A | 5lg3A-1qq0A:undetectable | 5lg3A-1qq0A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qv9 | F420-DEPENDENTMETHYLENETETRAHYDROMETHANOPTERINDEHYDROGENASE (Methanopyruskandleri) |
PF01993(MTD) | 5 | ILE A 9ILE A 68VAL A 38ILE A 59ALA A 60 | None | 1.11A | 5lg3A-1qv9A:3.5 | 5lg3A-1qv9A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvr | CLPB PROTEIN (Thermusthermophilus) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ILE A 704GLU A 668ASP A 667ILE A 669ALA A 672 | None | 1.12A | 5lg3A-1qvrA:2.8 | 5lg3A-1qvrA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut1 | DR HEMAGGLUTININSTRUCTURAL SUBUNIT (Escherichiacoli) |
PF04619(Adhesin_Dr) | 6 | ILE A 112ILE A 85PHE A 70VAL A 44THR A 11ALA A 60 | None | 1.50A | 5lg3A-1ut1A:undetectable | 5lg3A-1ut1A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyv | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF01039(Carboxyl_trans) | 5 | ILE A1619ILE A1803VAL A1584ASP A1796ALA A1518 | None | 0.92A | 5lg3A-1uyvA:undetectable | 5lg3A-1uyvA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj7 | BIFUNCTIONALRELA/SPOT (Streptococcusdysgalactiae) |
PF04607(RelA_SpoT)PF13328(HD_4) | 5 | ILE A 322ILE A 268VAL A 315THR A 313ILE A 285 | None | 1.09A | 5lg3A-1vj7A:undetectable | 5lg3A-1vj7A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykw | RUBISCO-LIKE PROTEIN (Chlorobaculumtepidum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ILE A 263ILE A 239THR A 280ASP A 251ALA A 258 | None | 1.14A | 5lg3A-1ykwA:undetectable | 5lg3A-1ykwA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zyp | ALKYL HYDROPEROXIDEREDUCTASE SUBUNIT F (Salmonellaenterica) |
PF13192(Thioredoxin_3) | 5 | ILE A 115ILE A 112VAL A 195ILE A 191ALA A 138 | None | 1.14A | 5lg3A-1zypA:undetectable | 5lg3A-1zypA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 5 | ILE A 291ILE A 249VAL A 89ASN A 128ILE A 119 | None | 1.10A | 5lg3A-2cl2A:undetectable | 5lg3A-2cl2A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cx9 | ACYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 100PHE A 112VAL A 57GLU A 106ALA A 111 | None | 1.09A | 5lg3A-2cx9A:2.5 | 5lg3A-2cx9A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dk5 | DNA-DIRECTED RNAPOLYMERASE III 39KDA POLYPEPTIDE (Homo sapiens) |
PF05158(RNA_pol_Rpc34) | 6 | ILE A 28ILE A 37VAL A 25ASN A 54TRP A 38ILE A 53 | None | 1.25A | 5lg3A-2dk5A:undetectable | 5lg3A-2dk5A:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dmz | INAD-LIKE PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE A 79ILE A 48VAL A 74ASP A 69ILE A 31 | None | 1.03A | 5lg3A-2dmzA:undetectable | 5lg3A-2dmzA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fko | 173AA LONGHYPOTHETICALFERRIPYOCHELINBINDING PROTEIN (Pyrococcushorikoshii) |
PF00132(Hexapep) | 5 | ILE A 74ILE A 80VAL A 52THR A 35ALA A 41 | None | 1.02A | 5lg3A-2fkoA:undetectable | 5lg3A-2fkoA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggq | 401AA LONGHYPOTHETICALGLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00132(Hexapep)PF00483(NTP_transferase) | 5 | ILE A 306ILE A 317THR A 365ILE A 371ALA A 357 | None | 1.11A | 5lg3A-2ggqA:undetectable | 5lg3A-2ggqA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdw | HYPOTHETICAL PROTEINPA2218 (Pseudomonasaeruginosa) |
PF02129(Peptidase_S15) | 5 | ILE A 101ILE A 99PHE A 125ILE A 359ALA A 360 | None | 1.02A | 5lg3A-2hdwA:undetectable | 5lg3A-2hdwA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxd | DCTP DEAMINASE,DUMP-FORMING (Methanocaldococcusjannaschii) |
PF00692(dUTPase) | 5 | ILE A 42ILE A 59VAL A 96ASP A 38ILE A 65 | None | 1.01A | 5lg3A-2hxdA:undetectable | 5lg3A-2hxdA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilu | ALDEHYDEDEHYDROGENASE A (Escherichiacoli) |
PF00171(Aldedh) | 5 | ILE A 86ILE A 191VAL A 105THR A 108ALA A 77 | None | 1.14A | 5lg3A-2iluA:undetectable | 5lg3A-2iluA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lv4 | PUTATIVE OUTERMEMBRANE OR EXPORTEDPROTEIN (Salmonellaenterica) |
PF16583(ZirS_C) | 5 | ILE A 258ILE A 272VAL A 219ASN A 223GLU A 254 | None | 0.89A | 5lg3A-2lv4A:undetectable | 5lg3A-2lv4A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pig | PUTATIVE TRANSFERASE (Salmonellaenterica) |
no annotation | 5 | ILE A 103ILE A 109THR A 72ILE A 74ALA A 78 | None | 0.97A | 5lg3A-2pigA:undetectable | 5lg3A-2pigA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjt | NICOTINAMIDE-NUCLEOTIDEADENYLYLTRANSFERASE (Francisellatularensis) |
no annotation | 5 | ILE B 303ILE B 257VAL B 312GLU B 250ALA B 208 | NoneNoneNone MN B 506 (-2.7A)None | 0.88A | 5lg3A-2qjtB:undetectable | 5lg3A-2qjtB:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1p | AQUAPORIN PIP2-7 7 (Komagataellapastoris) |
PF00230(MIP) | 5 | ILE A 131PHE A 128VAL A 120THR A 116GLU A 51 | None | 1.15A | 5lg3A-2w1pA:undetectable | 5lg3A-2w1pA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | ILE A 107PHE A 103ASN A 568GLU A 39ALA A 32 | None | 0.96A | 5lg3A-2x0qA:undetectable | 5lg3A-2x0qA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxd | PROBABLECOBALT-PRECORRIN-6YC(15)-METHYLTRANSFERASE[DECARBOXYLATING] (Methanocaldococcusjannaschii) |
PF13847(Methyltransf_31) | 5 | ILE A 112ILE A 115ASP A 120ILE A 127ALA A 104 | None | 1.05A | 5lg3A-2yxdA:undetectable | 5lg3A-2yxdA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z61 | PROBABLE ASPARTATEAMINOTRANSFERASE 2 (Methanocaldococcusjannaschii) |
PF00155(Aminotran_1_2) | 5 | ILE A 217ILE A 187VAL A 234ASN A 237ILE A 240 | None | 1.03A | 5lg3A-2z61A:undetectable | 5lg3A-2z61A:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj8 | PUTATIVE SKI2-TYPEHELICASE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C)PF14520(HHH_5) | 5 | ILE A 673PHE A 667VAL A 654THR A 691ILE A 687 | None | 1.12A | 5lg3A-2zj8A:undetectable | 5lg3A-2zj8A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1z | HEMOLYMPH JUVENILEHORMONE BINDINGPROTEIN (Bombyx mori) |
PF06585(JHBP) | 5 | ILE A 67PHE A 62THR A 120ILE A 193ALA A 192 | NoneNoneNoneNoneMPD A 232 ( 4.3A) | 1.04A | 5lg3A-3a1zA:undetectable | 5lg3A-3a1zA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqs | BACTERIAL REGULATORYPROTEINS, TETRFAMILY (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 5 | ILE A 56VAL A 51GLU A 75ASP A 73ALA A 80 | None | 1.13A | 5lg3A-3aqsA:3.1 | 5lg3A-3aqsA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3auf | GLYCINAMIDERIBONUCLEOTIDETRANSFORMYLASE 1 (Symbiobacteriumtoebii) |
PF00551(Formyl_trans_N) | 6 | ILE A 4ILE A 182VAL A 6ASN A 14GLU A 174ALA A 17 | None | 1.44A | 5lg3A-3aufA:undetectable | 5lg3A-3aufA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjx | HALOCARBOXYLIC ACIDDEHALOGENASE DEHI (Pseudomonasputida) |
PF10778(DehI) | 5 | ILE A 279ILE A 276PHE A 110VAL A 203ALA A 192 | None | 1.15A | 5lg3A-3bjxA:undetectable | 5lg3A-3bjxA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-ACETYLTRANSFERASE (Enterococcusfaecalis) |
PF00132(Hexapep)PF08503(DapH_N)PF14602(Hexapep_2) | 6 | ILE A 165ILE A 171VAL A 139THR A 125ILE A 127ALA A 131 | None | 0.95A | 5lg3A-3cj8A:undetectable | 5lg3A-3cj8A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cta | RIBOFLAVIN KINASE (Thermoplasmaacidophilum) |
PF01982(CTP-dep_RFKase)PF13545(HTH_Crp_2) | 5 | ILE A 196ILE A 134VAL A 182ASP A 192ILE A 95 | None | 1.06A | 5lg3A-3ctaA:undetectable | 5lg3A-3ctaA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfz | PRECORRIN-2DEHYDROGENASE (Bacillusmegaterium) |
PF13241(NAD_binding_7)PF14824(Sirohm_synth_M) | 5 | ILE A 36ILE A 26VAL A 13ASN A 98ALA A 77 | None | 0.96A | 5lg3A-3dfzA:undetectable | 5lg3A-3dfzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff6 | ACETYL-COACARBOXYLASE 2 (Homo sapiens) |
PF01039(Carboxyl_trans) | 5 | ILE A1825ILE A2006VAL A1790ASP A1999ALA A1727 | None | 1.11A | 5lg3A-3ff6A:2.4 | 5lg3A-3ff6A:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3a | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Leptospirainterrogans) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 39ILE A 45VAL A 21ILE A 9ALA A 13 | None | 1.01A | 5lg3A-3i3aA:undetectable | 5lg3A-3i3aA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5q | NUCLEOPORIN NUP170 (Saccharomycescerevisiae) |
no annotation | 5 | ILE B1271ILE B1275PHE B1311VAL B1268ASP B1298 | None | 1.15A | 5lg3A-3i5qB:undetectable | 5lg3A-3i5qB:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 5 | ILE A 195PHE A 188VAL A 168ILE A 207ALA A 173 | NoneNoneNoneFAD A 541 (-4.4A)None | 1.13A | 5lg3A-3js8A:undetectable | 5lg3A-3js8A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 5 | ILE A 78VAL A 10ASP A 58TRP A 50ALA A 65 | None | 1.00A | 5lg3A-3ls2A:undetectable | 5lg3A-3ls2A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nep | MALATE DEHYDROGENASE (Salinibacterruber) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE X 219ILE X 227PHE X 175VAL X 212THR X 206 | None | 1.02A | 5lg3A-3nepX:undetectable | 5lg3A-3nepX:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwp | 6-PHOSPHOGLUCONOLACTONASE (Shewanellabaltica) |
PF01182(Glucosamine_iso) | 5 | ILE A 188PHE A 129VAL A 218ASP A 71ALA A 181 | None | 1.09A | 5lg3A-3nwpA:undetectable | 5lg3A-3nwpA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6c | PYRIDOXINE5'-PHOSPHATESYNTHASE (Campylobacterjejuni) |
PF03740(PdxJ) | 5 | ILE A 38VAL A 31ASP A 23ILE A 10ALA A 11 | None | 1.06A | 5lg3A-3o6cA:undetectable | 5lg3A-3o6cA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om5 | LEVANSUCRASE (Bacillusmegaterium) |
PF02435(Glyco_hydro_68) | 5 | ILE A 142ILE A 76PHE A 133ASP A 92ALA A 117 | None | 1.15A | 5lg3A-3om5A:undetectable | 5lg3A-3om5A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 355ILE A 331PHE A 321ILE A 387ALA A 343 | None | 0.89A | 5lg3A-3oneA:undetectable | 5lg3A-3oneA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otm | CARBONIC ANHYDRASE (Methanosarcinathermophila) |
PF00132(Hexapep)PF14602(Hexapep_2) | 6 | ILE A 161ILE A 167VAL A 144THR A 131ILE A 133ALA A 137 | None | 0.96A | 5lg3A-3otmA:undetectable | 5lg3A-3otmA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 95ILE A 108VAL A 64THR A 50ILE A 52 | None | 0.96A | 5lg3A-3r0sA:undetectable | 5lg3A-3r0sA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | ILE A 372ILE A 332VAL A 408ILE A 382ALA A 296 | None | 0.85A | 5lg3A-3r5gA:undetectable | 5lg3A-3r5gA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swt | TAURINE CATABOLISMDIOXYGENASE, TAUD (Mycobacteriummarinum) |
PF02668(TauD) | 5 | PHE A 46ASP A 249TRP A 127ILE A 247ALA A 246 | None | 1.10A | 5lg3A-3swtA:undetectable | 5lg3A-3swtA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | ILE A 56ILE A 347GLU A 370ILE A 77ALA A 79 | None | 1.12A | 5lg3A-3t8lA:undetectable | 5lg3A-3t8lA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | ILE A 56ILE A 347VAL A 34GLU A 370ALA A 79 | None | 1.12A | 5lg3A-3t8lA:undetectable | 5lg3A-3t8lA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uvj | GUANYLATE CYCLASESOLUBLE SUBUNITALPHA-3 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ILE A 571ILE A 487PHE A 490VAL A 563ASN A 507 | None | 1.09A | 5lg3A-3uvjA:undetectable | 5lg3A-3uvjA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2h | D-BETA-HYDROXYBUTYRATE DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ILE A 181ILE A 136VAL A 249ILE A 244ALA A 241 | None | 1.10A | 5lg3A-3v2hA:undetectable | 5lg3A-3v2hA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX IIIRON-SULFUR SUBUNITOF SUCCINATEDEHYDROGENASE (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF13085(Fer2_3)PF13534(Fer4_17) | 5 | ILE B 132ILE A 538VAL B 136THR B 84ASP A 534 | None | 1.04A | 5lg3A-3vrbB:undetectable | 5lg3A-3vrbB:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ac3 | BIFUNCTIONAL PROTEINGLMU (Streptococcuspneumoniae) |
PF00132(Hexapep)PF00483(NTP_transferase)PF14602(Hexapep_2) | 5 | ILE A 286VAL A 298THR A 296ILE A 309ALA A 307 | None | 1.12A | 5lg3A-4ac3A:undetectable | 5lg3A-4ac3A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ILE A 323ILE A 322VAL A 292ILE A 305ALA A 308 | None | 1.04A | 5lg3A-4c13A:undetectable | 5lg3A-4c13A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | ILE A 801VAL A 888THR A 886ILE A 815ALA A 907 | None | 0.87A | 5lg3A-4cakA:2.1 | 5lg3A-4cakA:16.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvy | DIOXYGENASERV3406/MT3514 (Mycobacteriumtuberculosis) |
PF02668(TauD) | 5 | PHE A 45ASP A 245TRP A 126ILE A 243ALA A 242 | None | 1.12A | 5lg3A-4cvyA:undetectable | 5lg3A-4cvyA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gaa | MGC78867 PROTEIN (Xenopus laevis) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | ILE A 257ILE A 217VAL A 275THR A 273ILE A 290 | None | 1.08A | 5lg3A-4gaaA:4.5 | 5lg3A-4gaaA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 5 | PHE A 45ASP A 242TRP A 124ILE A 240ALA A 239 | None | 1.08A | 5lg3A-4j5iA:undetectable | 5lg3A-4j5iA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz0 | CURL (Mooreaproducens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 460ILE A 298VAL A 398ILE A 279ALA A 233 | None | 0.98A | 5lg3A-4mz0A:undetectable | 5lg3A-4mz0A:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n27 | BACTERIALTRANSFERASEHEXAPEPTIDE REPEAT (Brucellaabortus) |
PF00132(Hexapep) | 5 | ILE A 129VAL A 111THR A 97ILE A 99ALA A 103 | None | 0.95A | 5lg3A-4n27A:undetectable | 5lg3A-4n27A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuh | ICE-BINDING PROTEIN (Leucosporidium) |
PF11999(DUF3494) | 5 | ILE A 56ILE A 45VAL A 52ILE A 17ALA A 19 | None | 1.11A | 5lg3A-4nuhA:undetectable | 5lg3A-4nuhA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nur | PSDSA (Pseudomonas sp.S9) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 5 | ILE A 157ILE A 150VAL A 185ASP A 161ALA A 172 | None | 0.94A | 5lg3A-4nurA:2.1 | 5lg3A-4nurA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqq | DEOXYRIBONUCLEOSIDEREGULATOR (Bacillussubtilis) |
PF04198(Sugar-bind) | 5 | PHE A 207THR A 105GLU A 272ILE A 204ALA A 205 | None | 1.00A | 5lg3A-4oqqA:undetectable | 5lg3A-4oqqA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ILE A 79ILE A 48VAL A 396THR A 405ILE A 407 | None | 1.01A | 5lg3A-4oyaA:undetectable | 5lg3A-4oyaA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q00 | FERROUS IRONTRANSPORT PROTEIN B (Escherichiacoli) |
PF02421(FeoB_N) | 5 | ILE A 6ILE A 90VAL A 52GLU A 157ALA A 162 | None | 1.06A | 5lg3A-4q00A:undetectable | 5lg3A-4q00A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qwo | PROFILIN (Monkeypox virus) |
PF00235(Profilin) | 5 | VAL A 128THR A 99ASP A 24ILE A 22ALA A 33 | None | 1.03A | 5lg3A-4qwoA:undetectable | 5lg3A-4qwoA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 5 | ILE A 117VAL A 122THR A 125ASN A 129ILE A 160 | None | 1.14A | 5lg3A-4s3jA:undetectable | 5lg3A-4s3jA:22.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23ASP A 158TRP A 160ILE A 162ALA A 197 | None | 0.66A | 5lg3A-4twfA:32.5 | 5lg3A-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126ASP A 158TRP A 160ALA A 197 | None | 0.49A | 5lg3A-4twfA:32.5 | 5lg3A-4twfA:99.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twf | CYS-LOOPLIGAND-GATED IONCHANNEL (Dickeyachrysanthemi) |
PF02931(Neur_chan_LBD) | 5 | ILE A 23PHE A 126GLU A 155TRP A 160ALA A 197 | None | 0.93A | 5lg3A-4twfA:32.5 | 5lg3A-4twfA:99.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ufc | GH95 (Bacteroidesovatus) |
PF14498(Glyco_hyd_65N_2) | 5 | ILE A 471ILE A 452THR A 475TRP A 453ALA A 526 | None | 1.09A | 5lg3A-4ufcA:undetectable | 5lg3A-4ufcA:18.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126ASP A 158TRP A 160ALA A 197 | None | 0.68A | 5lg3A-4yeuA:29.3 | 5lg3A-4yeuA:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126TRP A 160ILE A 162ALA A 197 | None | 0.70A | 5lg3A-4yeuA:29.3 | 5lg3A-4yeuA:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 6 | ILE A 20ILE A 23PHE A 126VAL A 147TRP A 160ALA A 197 | None | 0.66A | 5lg3A-4yeuA:29.3 | 5lg3A-4yeuA:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yeu | CYS-LOOPLIGAND-GATED IONCHANNEL,PROTON-GATEDION CHANNEL (Dickeyachrysanthemi;Gloeobacterviolaceus) |
PF02931(Neur_chan_LBD) | 5 | ILE A 23PHE A 126THR A 149TRP A 160ILE A 162 | None | 0.91A | 5lg3A-4yeuA:29.3 | 5lg3A-4yeuA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | ILE A 826VAL A 842ASP A 838ILE A 758ALA A 815 | None | 1.04A | 5lg3A-4ypjA:3.4 | 5lg3A-4ypjA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | ILE A 826VAL A 842THR A 840ILE A 758ALA A 815 | None | 1.06A | 5lg3A-4ypjA:3.4 | 5lg3A-4ypjA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 5 | ILE A1619ILE A1803VAL A1584ASP A1796ALA A1518 | None | 0.97A | 5lg3A-5cslA:3.2 | 5lg3A-5cslA:8.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fi5 | TETRAHYDROALSTONINESYNTHASE (Catharanthusroseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 326ILE A 349VAL A 329GLU A 77ALA A 133 | NoneNoneNone ZN A 402 (-3.0A)None | 1.01A | 5lg3A-5fi5A:undetectable | 5lg3A-5fi5A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g6r | IMINE REDUCTASE (Aspergillusoryzae) |
PF03446(NAD_binding_2) | 5 | ILE A 63ILE A 5VAL A 89THR A 87ILE A 145 | None | 1.09A | 5lg3A-5g6rA:undetectable | 5lg3A-5g6rA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6g | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | ILE A1664ILE A1843VAL A1629ASP A1836ALA A1556 | None | 0.99A | 5lg3A-5i6gA:2.3 | 5lg3A-5i6gA:14.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6h | ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | ILE A1664ILE A1843VAL A1629ASP A1836ALA A1556 | None | 0.97A | 5lg3A-5i6hA:undetectable | 5lg3A-5i6hA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6i | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | ILE A1664ILE A1843VAL A1629ASP A1836ALA A1556 | None | 1.06A | 5lg3A-5i6iA:undetectable | 5lg3A-5i6iA:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxx | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Moraxellacatarrhalis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 45ILE A 51VAL A 27ILE A 15ALA A 19 | None | 0.84A | 5lg3A-5jxxA:undetectable | 5lg3A-5jxxA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9h | 0940_GH29 (unidentified) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 5 | ILE A 302ILE A 308PHE A 300ILE A 70ALA A 24 | None | 0.94A | 5lg3A-5k9hA:undetectable | 5lg3A-5k9hA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6s | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASE (Escherichiacoli) |
PF00483(NTP_transferase) | 5 | ILE A 390ILE A 396VAL A 373ILE A 362ALA A 365 | None | 1.11A | 5lg3A-5l6sA:undetectable | 5lg3A-5l6sA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ILE A 39ILE A 44VAL A 230ILE A 82ALA A 83 | None | 0.92A | 5lg3A-5n9xA:undetectable | 5lg3A-5n9xA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 5 | ILE A 147VAL A 71ASP A 247ILE A 48ALA A 121 | None | 1.13A | 5lg3A-5oynA:undetectable | 5lg3A-5oynA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux9 | CHLORAMPHENICOLACETYLTRANSFERASE (Aliivibriofischeri) |
PF00132(Hexapep) | 5 | ILE A 139ILE A 145VAL A 121ILE A 76ALA A 80 | None | 1.05A | 5lg3A-5ux9A:undetectable | 5lg3A-5ux9A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj7 | OXIDOREDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | ILE A 233ILE A 160THR A 435ILE A 427ALA A 446 | None | 1.13A | 5lg3A-5vj7A:undetectable | 5lg3A-5vj7A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkq | NO MECHANORECEPTORPOTENTIAL C ISOFORML (Drosophilamelanogaster) |
PF00023(Ank)PF00520(Ion_trans)PF12796(Ank_2)PF13637(Ank_4) | 5 | ILE A 797PHE A 812VAL A 842ASN A 803ALA A 768 | None | 0.95A | 5lg3A-5vkqA:3.4 | 5lg3A-5vkqA:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vn6 | TAURINE DIOXYGENASE (Burkholderiaambifaria) |
PF02668(TauD) | 5 | PHE A 43ASP A 252TRP A 127ILE A 250ALA A 249 | None | 1.02A | 5lg3A-5vn6A:undetectable | 5lg3A-5vn6A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 5 | ILE A 206ILE A 194ASP A 114ILE A 102ALA A 236 | NoneNoneEDO A 506 (-3.4A)NoneNone | 1.04A | 5lg3A-6gu8A:undetectable | 5lg3A-6gu8A:undetectable |