SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_A_Z80A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE


(Shewanella
oneidensis)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
5 ILE A 131
VAL A 277
ASP A 270
ILE A 303
ALA A 305
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.2A)
None
None
None
1.07A 5lg3A-1d4eA:
undetectable
5lg3A-1d4eA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
5 ILE A 107
ILE A  97
THR A  83
ASP A 100
ALA A  68
None
1.08A 5lg3A-1fuiA:
0.0
5lg3A-1fuiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE


(Escherichia
coli)
PF02668
(TauD)
5 PHE A  46
ASP A 249
TRP A 128
ILE A 247
ALA A 246
None
1.04A 5lg3A-1gy9A:
0.0
5lg3A-1gy9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE O  93
PHE O  91
ASN O  22
ILE O  25
ALA O   1
None
1.06A 5lg3A-1hdgO:
0.1
5lg3A-1hdgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 VAL A 101
ASP A  79
TRP A  81
ILE A  76
ALA A  75
None
1.14A 5lg3A-1idjA:
0.0
5lg3A-1idjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger)
PF00295
(Glyco_hydro_28)
5 ILE A 190
ILE A 210
PHE A 220
VAL A 160
ALA A 201
None
0.67A 5lg3A-1nhcA:
undetectable
5lg3A-1nhcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK


(Pseudomonas
putida)
PF02668
(TauD)
5 PHE C  56
ASP C 258
TRP C 137
ILE C 256
ALA C 255
None
1.12A 5lg3A-1oijC:
0.0
5lg3A-1oijC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
1.15A 5lg3A-1pk8A:
0.0
5lg3A-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
6 ILE A 161
ILE A 167
VAL A 144
THR A 131
ILE A 133
ALA A 137
None
0.97A 5lg3A-1qq0A:
undetectable
5lg3A-1qq0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE


(Methanopyrus
kandleri)
PF01993
(MTD)
5 ILE A   9
ILE A  68
VAL A  38
ILE A  59
ALA A  60
None
1.11A 5lg3A-1qv9A:
3.5
5lg3A-1qv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
5 ILE A 704
GLU A 668
ASP A 667
ILE A 669
ALA A 672
None
1.12A 5lg3A-1qvrA:
2.8
5lg3A-1qvrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut1 DR HEMAGGLUTININ
STRUCTURAL SUBUNIT


(Escherichia
coli)
PF04619
(Adhesin_Dr)
6 ILE A 112
ILE A  85
PHE A  70
VAL A  44
THR A  11
ALA A  60
None
1.50A 5lg3A-1ut1A:
undetectable
5lg3A-1ut1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF01039
(Carboxyl_trans)
5 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
None
0.92A 5lg3A-1uyvA:
undetectable
5lg3A-1uyvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT


(Streptococcus
dysgalactiae)
PF04607
(RelA_SpoT)
PF13328
(HD_4)
5 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
None
1.09A 5lg3A-1vj7A:
undetectable
5lg3A-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ILE A 263
ILE A 239
THR A 280
ASP A 251
ALA A 258
None
1.14A 5lg3A-1ykwA:
undetectable
5lg3A-1ykwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F


(Salmonella
enterica)
PF13192
(Thioredoxin_3)
5 ILE A 115
ILE A 112
VAL A 195
ILE A 191
ALA A 138
None
1.14A 5lg3A-1zypA:
undetectable
5lg3A-1zypA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 5 ILE A 291
ILE A 249
VAL A  89
ASN A 128
ILE A 119
None
1.10A 5lg3A-2cl2A:
undetectable
5lg3A-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A 100
PHE A 112
VAL A  57
GLU A 106
ALA A 111
None
1.09A 5lg3A-2cx9A:
2.5
5lg3A-2cx9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE


(Homo sapiens)
PF05158
(RNA_pol_Rpc34)
6 ILE A  28
ILE A  37
VAL A  25
ASN A  54
TRP A  38
ILE A  53
None
1.25A 5lg3A-2dk5A:
undetectable
5lg3A-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmz INAD-LIKE PROTEIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE A  79
ILE A  48
VAL A  74
ASP A  69
ILE A  31
None
1.03A 5lg3A-2dmzA:
undetectable
5lg3A-2dmzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00132
(Hexapep)
5 ILE A  74
ILE A  80
VAL A  52
THR A  35
ALA A  41
None
1.02A 5lg3A-2fkoA:
undetectable
5lg3A-2fkoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ILE A 306
ILE A 317
THR A 365
ILE A 371
ALA A 357
None
1.11A 5lg3A-2ggqA:
undetectable
5lg3A-2ggqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218


(Pseudomonas
aeruginosa)
PF02129
(Peptidase_S15)
5 ILE A 101
ILE A  99
PHE A 125
ILE A 359
ALA A 360
None
1.02A 5lg3A-2hdwA:
undetectable
5lg3A-2hdwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING


(Methanocaldococcus
jannaschii)
PF00692
(dUTPase)
5 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
None
1.01A 5lg3A-2hxdA:
undetectable
5lg3A-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A


(Escherichia
coli)
PF00171
(Aldedh)
5 ILE A  86
ILE A 191
VAL A 105
THR A 108
ALA A  77
None
1.14A 5lg3A-2iluA:
undetectable
5lg3A-2iluA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv4 PUTATIVE OUTER
MEMBRANE OR EXPORTED
PROTEIN


(Salmonella
enterica)
PF16583
(ZirS_C)
5 ILE A 258
ILE A 272
VAL A 219
ASN A 223
GLU A 254
None
0.89A 5lg3A-2lv4A:
undetectable
5lg3A-2lv4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica)
no annotation 5 ILE A 103
ILE A 109
THR A  72
ILE A  74
ALA A  78
None
0.97A 5lg3A-2pigA:
undetectable
5lg3A-2pigA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE


(Francisella
tularensis)
no annotation 5 ILE B 303
ILE B 257
VAL B 312
GLU B 250
ALA B 208
None
None
None
MN  B 506 (-2.7A)
None
0.88A 5lg3A-2qjtB:
undetectable
5lg3A-2qjtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7


(Komagataella
pastoris)
PF00230
(MIP)
5 ILE A 131
PHE A 128
VAL A 120
THR A 116
GLU A  51
None
1.15A 5lg3A-2w1pA:
undetectable
5lg3A-2w1pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
5 ILE A 107
PHE A 103
ASN A 568
GLU A  39
ALA A  32
None
0.96A 5lg3A-2x0qA:
undetectable
5lg3A-2x0qA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]


(Methanocaldococcus
jannaschii)
PF13847
(Methyltransf_31)
5 ILE A 112
ILE A 115
ASP A 120
ILE A 127
ALA A 104
None
1.05A 5lg3A-2yxdA:
undetectable
5lg3A-2yxdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2


(Methanocaldococcus
jannaschii)
PF00155
(Aminotran_1_2)
5 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
None
1.03A 5lg3A-2z61A:
undetectable
5lg3A-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
5 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
None
1.12A 5lg3A-2zj8A:
undetectable
5lg3A-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN


(Bombyx mori)
PF06585
(JHBP)
5 ILE A  67
PHE A  62
THR A 120
ILE A 193
ALA A 192
None
None
None
None
MPD  A 232 ( 4.3A)
1.04A 5lg3A-3a1zA:
undetectable
5lg3A-3a1zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY


(Corynebacterium
glutamicum)
PF00440
(TetR_N)
5 ILE A  56
VAL A  51
GLU A  75
ASP A  73
ALA A  80
None
1.13A 5lg3A-3aqsA:
3.1
5lg3A-3aqsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1


(Symbiobacterium
toebii)
PF00551
(Formyl_trans_N)
6 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
ALA A  17
None
1.44A 5lg3A-3aufA:
undetectable
5lg3A-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI


(Pseudomonas
putida)
PF10778
(DehI)
5 ILE A 279
ILE A 276
PHE A 110
VAL A 203
ALA A 192
None
1.15A 5lg3A-3bjxA:
undetectable
5lg3A-3bjxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE


(Enterococcus
faecalis)
PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2)
6 ILE A 165
ILE A 171
VAL A 139
THR A 125
ILE A 127
ALA A 131
None
0.95A 5lg3A-3cj8A:
undetectable
5lg3A-3cj8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cta RIBOFLAVIN KINASE

(Thermoplasma
acidophilum)
PF01982
(CTP-dep_RFKase)
PF13545
(HTH_Crp_2)
5 ILE A 196
ILE A 134
VAL A 182
ASP A 192
ILE A  95
None
1.06A 5lg3A-3ctaA:
undetectable
5lg3A-3ctaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfz PRECORRIN-2
DEHYDROGENASE


(Bacillus
megaterium)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M)
5 ILE A  36
ILE A  26
VAL A  13
ASN A  98
ALA A  77
None
0.96A 5lg3A-3dfzA:
undetectable
5lg3A-3dfzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2


(Homo sapiens)
PF01039
(Carboxyl_trans)
5 ILE A1825
ILE A2006
VAL A1790
ASP A1999
ALA A1727
None
1.11A 5lg3A-3ff6A:
2.4
5lg3A-3ff6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Leptospira
interrogans)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  39
ILE A  45
VAL A  21
ILE A   9
ALA A  13
None
1.01A 5lg3A-3i3aA:
undetectable
5lg3A-3i3aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae)
no annotation 5 ILE B1271
ILE B1275
PHE B1311
VAL B1268
ASP B1298
None
1.15A 5lg3A-3i5qB:
undetectable
5lg3A-3i5qB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 ILE A 195
PHE A 188
VAL A 168
ILE A 207
ALA A 173
None
None
None
FAD  A 541 (-4.4A)
None
1.13A 5lg3A-3js8A:
undetectable
5lg3A-3js8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE


(Pseudoalteromonas
haloplanktis)
PF00756
(Esterase)
5 ILE A  78
VAL A  10
ASP A  58
TRP A  50
ALA A  65
None
1.00A 5lg3A-3ls2A:
undetectable
5lg3A-3ls2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE X 219
ILE X 227
PHE X 175
VAL X 212
THR X 206
None
1.02A 5lg3A-3nepX:
undetectable
5lg3A-3nepX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE


(Shewanella
baltica)
PF01182
(Glucosamine_iso)
5 ILE A 188
PHE A 129
VAL A 218
ASP A  71
ALA A 181
None
1.09A 5lg3A-3nwpA:
undetectable
5lg3A-3nwpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Campylobacter
jejuni)
PF03740
(PdxJ)
5 ILE A  38
VAL A  31
ASP A  23
ILE A  10
ALA A  11
None
1.06A 5lg3A-3o6cA:
undetectable
5lg3A-3o6cA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium)
PF02435
(Glyco_hydro_68)
5 ILE A 142
ILE A  76
PHE A 133
ASP A  92
ALA A 117
None
1.15A 5lg3A-3om5A:
undetectable
5lg3A-3om5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 355
ILE A 331
PHE A 321
ILE A 387
ALA A 343
None
0.89A 5lg3A-3oneA:
undetectable
5lg3A-3oneA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
6 ILE A 161
ILE A 167
VAL A 144
THR A 131
ILE A 133
ALA A 137
None
0.96A 5lg3A-3otmA:
undetectable
5lg3A-3otmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  95
ILE A 108
VAL A  64
THR A  50
ILE A  52
None
0.96A 5lg3A-3r0sA:
undetectable
5lg3A-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa)
PF00211
(Guanylate_cyc)
5 ILE A 372
ILE A 332
VAL A 408
ILE A 382
ALA A 296
None
0.85A 5lg3A-3r5gA:
undetectable
5lg3A-3r5gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD


(Mycobacterium
marinum)
PF02668
(TauD)
5 PHE A  46
ASP A 249
TRP A 127
ILE A 247
ALA A 246
None
1.10A 5lg3A-3swtA:
undetectable
5lg3A-3swtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
5 ILE A  56
ILE A 347
GLU A 370
ILE A  77
ALA A  79
None
1.12A 5lg3A-3t8lA:
undetectable
5lg3A-3t8lA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
5 ILE A  56
ILE A 347
VAL A  34
GLU A 370
ALA A  79
None
1.12A 5lg3A-3t8lA:
undetectable
5lg3A-3t8lA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
1.09A 5lg3A-3uvjA:
undetectable
5lg3A-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 ILE A 181
ILE A 136
VAL A 249
ILE A 244
ALA A 241
None
1.10A 5lg3A-3v2hA:
undetectable
5lg3A-3v2hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
None
1.04A 5lg3A-3vrbB:
undetectable
5lg3A-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU


(Streptococcus
pneumoniae)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2)
5 ILE A 286
VAL A 298
THR A 296
ILE A 309
ALA A 307
None
1.12A 5lg3A-4ac3A:
undetectable
5lg3A-4ac3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE


(Staphylococcus
aureus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ILE A 323
ILE A 322
VAL A 292
ILE A 305
ALA A 308
None
1.04A 5lg3A-4c13A:
undetectable
5lg3A-4c13A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 ILE A 801
VAL A 888
THR A 886
ILE A 815
ALA A 907
None
0.87A 5lg3A-4cakA:
2.1
5lg3A-4cakA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514


(Mycobacterium
tuberculosis)
PF02668
(TauD)
5 PHE A  45
ASP A 245
TRP A 126
ILE A 243
ALA A 242
None
1.12A 5lg3A-4cvyA:
undetectable
5lg3A-4cvyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
None
1.08A 5lg3A-4gaaA:
4.5
5lg3A-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE


(Mycolicibacterium
smegmatis)
PF02668
(TauD)
5 PHE A  45
ASP A 242
TRP A 124
ILE A 240
ALA A 239
None
1.08A 5lg3A-4j5iA:
undetectable
5lg3A-4j5iA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 460
ILE A 298
VAL A 398
ILE A 279
ALA A 233
None
0.98A 5lg3A-4mz0A:
undetectable
5lg3A-4mz0A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT


(Brucella
abortus)
PF00132
(Hexapep)
5 ILE A 129
VAL A 111
THR A  97
ILE A  99
ALA A 103
None
0.95A 5lg3A-4n27A:
undetectable
5lg3A-4n27A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium)
PF11999
(DUF3494)
5 ILE A  56
ILE A  45
VAL A  52
ILE A  17
ALA A  19
None
1.11A 5lg3A-4nuhA:
undetectable
5lg3A-4nuhA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
5 ILE A 157
ILE A 150
VAL A 185
ASP A 161
ALA A 172
None
0.94A 5lg3A-4nurA:
2.1
5lg3A-4nurA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR


(Bacillus
subtilis)
PF04198
(Sugar-bind)
5 PHE A 207
THR A 105
GLU A 272
ILE A 204
ALA A 205
None
1.00A 5lg3A-4oqqA:
undetectable
5lg3A-4oqqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
1.01A 5lg3A-4oyaA:
undetectable
5lg3A-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q00 FERROUS IRON
TRANSPORT PROTEIN B


(Escherichia
coli)
PF02421
(FeoB_N)
5 ILE A   6
ILE A  90
VAL A  52
GLU A 157
ALA A 162
None
1.06A 5lg3A-4q00A:
undetectable
5lg3A-4q00A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwo PROFILIN

(Monkeypox virus)
PF00235
(Profilin)
5 VAL A 128
THR A  99
ASP A  24
ILE A  22
ALA A  33
None
1.03A 5lg3A-4qwoA:
undetectable
5lg3A-4qwoA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
5 ILE A 117
VAL A 122
THR A 125
ASN A 129
ILE A 160
None
1.14A 5lg3A-4s3jA:
undetectable
5lg3A-4s3jA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
ASP A 158
TRP A 160
ILE A 162
ALA A 197
None
0.66A 5lg3A-4twfA:
32.5
5lg3A-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
ALA A 197
None
0.49A 5lg3A-4twfA:
32.5
5lg3A-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
GLU A 155
TRP A 160
ALA A 197
None
0.93A 5lg3A-4twfA:
32.5
5lg3A-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus)
PF14498
(Glyco_hyd_65N_2)
5 ILE A 471
ILE A 452
THR A 475
TRP A 453
ALA A 526
None
1.09A 5lg3A-4ufcA:
undetectable
5lg3A-4ufcA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
ALA A 197
None
0.68A 5lg3A-4yeuA:
29.3
5lg3A-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
TRP A 160
ILE A 162
ALA A 197
None
0.70A 5lg3A-4yeuA:
29.3
5lg3A-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
VAL A 147
TRP A 160
ALA A 197
None
0.66A 5lg3A-4yeuA:
29.3
5lg3A-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
THR A 149
TRP A 160
ILE A 162
None
0.91A 5lg3A-4yeuA:
29.3
5lg3A-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 ILE A 826
VAL A 842
ASP A 838
ILE A 758
ALA A 815
None
1.04A 5lg3A-4ypjA:
3.4
5lg3A-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 ILE A 826
VAL A 842
THR A 840
ILE A 758
ALA A 815
None
1.06A 5lg3A-4ypjA:
3.4
5lg3A-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
5 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
None
0.97A 5lg3A-5cslA:
3.2
5lg3A-5cslA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE


(Catharanthus
roseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 326
ILE A 349
VAL A 329
GLU A  77
ALA A 133
None
None
None
ZN  A 402 (-3.0A)
None
1.01A 5lg3A-5fi5A:
undetectable
5lg3A-5fi5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae)
PF03446
(NAD_binding_2)
5 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
None
1.09A 5lg3A-5g6rA:
undetectable
5lg3A-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 ILE A1664
ILE A1843
VAL A1629
ASP A1836
ALA A1556
None
0.99A 5lg3A-5i6gA:
2.3
5lg3A-5i6gA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 ILE A1664
ILE A1843
VAL A1629
ASP A1836
ALA A1556
None
0.97A 5lg3A-5i6hA:
undetectable
5lg3A-5i6hA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 ILE A1664
ILE A1843
VAL A1629
ASP A1836
ALA A1556
None
1.06A 5lg3A-5i6iA:
undetectable
5lg3A-5i6iA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxx ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Moraxella
catarrhalis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  45
ILE A  51
VAL A  27
ILE A  15
ALA A  19
None
0.84A 5lg3A-5jxxA:
undetectable
5lg3A-5jxxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
5 ILE A 302
ILE A 308
PHE A 300
ILE A  70
ALA A  24
None
0.94A 5lg3A-5k9hA:
undetectable
5lg3A-5k9hA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF00483
(NTP_transferase)
5 ILE A 390
ILE A 396
VAL A 373
ILE A 362
ALA A 365
None
1.11A 5lg3A-5l6sA:
undetectable
5lg3A-5l6sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A  39
ILE A  44
VAL A 230
ILE A  82
ALA A  83
None
0.92A 5lg3A-5n9xA:
undetectable
5lg3A-5n9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY


(Caulobacter
vibrioides)
no annotation 5 ILE A 147
VAL A  71
ASP A 247
ILE A  48
ALA A 121
None
1.13A 5lg3A-5oynA:
undetectable
5lg3A-5oynA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux9 CHLORAMPHENICOL
ACETYLTRANSFERASE


(Aliivibrio
fischeri)
PF00132
(Hexapep)
5 ILE A 139
ILE A 145
VAL A 121
ILE A  76
ALA A  80
None
1.05A 5lg3A-5ux9A:
undetectable
5lg3A-5ux9A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
5 ILE A 233
ILE A 160
THR A 435
ILE A 427
ALA A 446
None
1.13A 5lg3A-5vj7A:
undetectable
5lg3A-5vj7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L


(Drosophila
melanogaster)
PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 ILE A 797
PHE A 812
VAL A 842
ASN A 803
ALA A 768
None
0.95A 5lg3A-5vkqA:
3.4
5lg3A-5vkqA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria)
PF02668
(TauD)
5 PHE A  43
ASP A 252
TRP A 127
ILE A 250
ALA A 249
None
1.02A 5lg3A-5vn6A:
undetectable
5lg3A-5vn6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-)
no annotation 5 ILE A 206
ILE A 194
ASP A 114
ILE A 102
ALA A 236
None
None
EDO  A 506 (-3.4A)
None
None
1.04A 5lg3A-6gu8A:
undetectable
5lg3A-6gu8A:
undetectable