SIMILAR PATTERNS OF AMINO ACIDS FOR 5LF3_B_BO2B305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		5 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.16A 5lf3b-1cemA:
undetectable		 5lf3b-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.19A 5lf3b-1csjA:
undetectable		 5lf3b-1csjA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 THR C 168
ARG C 281
SER C 174
GLY C 178
ALA C 184
 CA  C1600 (-3.5A)
None
CA  C1600 (-2.5A)
None
None
 1.39A 5lf3b-1d7wC:
undetectable		 5lf3b-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 THR C 168
THR A  11
ARG C 281
SER C 174
GLY C 178
 CA  C1600 (-3.5A)
None
None
CA  C1600 (-2.5A)
None
 1.26A 5lf3b-1d7wC:
undetectable		 5lf3b-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		5 THR A 148
GLY A 208
ALA A 211
THR A 213
SER A 202
 None
 1.15A 5lf3b-1e08A:
undetectable		 5lf3b-1e08A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 SER A 365
GLY A 366
ALA A 368
THR A 131
SER A 353
 XPL  A 202 ( 2.7A)
None
None
XPL  A 202 ( 4.5A)
None
 1.40A 5lf3b-1l2qA:
undetectable		 5lf3b-1l2qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.06A 5lf3b-1l2qA:
undetectable		 5lf3b-1l2qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 THR A  14
THR A  13
SER A  31
GLY A  32
ALA A  52
 None
 1.15A 5lf3b-1nbwA:
undetectable		 5lf3b-1nbwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 124
SER A 166
GLY A 106
ALA A 104
SER A  86
 None
 1.34A 5lf3b-1ozhA:
undetectable		 5lf3b-1ozhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 THR X 240
THR X 239
ARG X 346
ALA X 246
SER X 310
 None
 1.19A 5lf3b-1pp1X:
undetectable		 5lf3b-1pp1X:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 THR H   1
THR H  21
LYS H  33
GLY H  47
ALA H  49
 None
 0.54A 5lf3b-1q5qH:
26.4		 5lf3b-1q5qH:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnc E2 GLYCOPROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2) 		5 THR A 921
THR A 922
THR A 923
SER A 914
ALA A1171
 None
 1.38A 5lf3b-1wncA:
undetectable		 5lf3b-1wncA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyy E2 GLYCOPROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2) 		5 THR A 921
THR A 922
THR A 923
SER A 914
ALA A1171
 None
 1.28A 5lf3b-1wyyA:
undetectable		 5lf3b-1wyyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
 None
 1.19A 5lf3b-1xkwA:
undetectable		 5lf3b-1xkwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 THR A 346
THR A 349
ARG A 287
GLY A 343
MET A 175
 SO4  A2002 (-3.6A)
None
SO4  A2001 (-3.1A)
None
None
 1.40A 5lf3b-1yirA:
undetectable		 5lf3b-1yirA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 THR A1009
THR A1128
SER A1019
GLY A 984
ALA A1123
 None
 1.36A 5lf3b-2bzlA:
undetectable		 5lf3b-2bzlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 5 THR H 301
THR H 321
LYS H 333
GLY H 347
ALA H 349
 None
 0.57A 5lf3b-2fhgH:
25.5		 5lf3b-2fhgH:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 THR A 287
THR A 291
THR A 292
SER A 270
GLY A 271
 None
 1.26A 5lf3b-2fkjA:
undetectable		 5lf3b-2fkjA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		5 THR A 168
THR A  11
ARG A 281
SER A 174
GLY A 178
 CA  A1503 (-3.8A)
None
None
CA  A1503 (-2.6A)
None
 1.22A 5lf3b-2gjmA:
undetectable		 5lf3b-2gjmA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.18A 5lf3b-2iphA:
undetectable		 5lf3b-2iphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 THR A 267
THR A 268
THR A 269
SER A 356
MET A 144
 None
None
None
CSF  A1415 (-2.6A)
CSF  A1415 ( 3.8A)
 1.16A 5lf3b-2iy8A:
undetectable		 5lf3b-2iy8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 THR A 128
THR A 131
SER A 122
GLY A 123
ALA A 261
 None
 1.40A 5lf3b-2o6xA:
undetectable		 5lf3b-2o6xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 THR O 174
THR O 175
SER O 153
GLY O 154
ALA O 156
 None
 1.22A 5lf3b-2ol8O:
undetectable		 5lf3b-2ol8O:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 THR A 121
ARG A 143
SER A 139
GLY A 142
ALA A 144
 None
 1.38A 5lf3b-2pi5A:
undetectable		 5lf3b-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 THR A 121
THR A 118
SER A 139
GLY A 142
ALA A 144
 None
 1.33A 5lf3b-2pi5A:
undetectable		 5lf3b-2pi5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF02542
(YgbB) 		5 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
 None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
 1.40A 5lf3b-2uzhA:
undetectable		 5lf3b-2uzhA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA

(Aspergillus
nidulans) 		PF00320
(GATA)
PF05368
(NmrA) 		5 THR I 681
THR I 680
ARG A 322
SER A 326
GLY A 327
 None
 1.27A 5lf3b-2vutI:
undetectable		 5lf3b-2vutI:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 THR A 162
THR A 163
ALA A 140
THR A 143
SER A 172
 None
 1.30A 5lf3b-2wyaA:
undetectable		 5lf3b-2wyaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.88A 5lf3b-2wyaA:
undetectable		 5lf3b-2wyaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 THR A 244
THR A 266
SER A 237
GLY A 238
ALA A 172
 None
 1.22A 5lf3b-2wyxA:
undetectable		 5lf3b-2wyxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.33A 5lf3b-2xymA:
undetectable		 5lf3b-2xymA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ad9 SARCOSINE OXIDASE
GAMMA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04268
(SoxG) 		5 THR C  38
THR C  39
SER C  75
GLY C  76
ALA C  78
 None
 1.32A 5lf3b-3ad9C:
undetectable		 5lf3b-3ad9C:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		5 THR A 163
LYS A 376
ARG A 377
SER A 378
GLY A 379
 None
 1.37A 5lf3b-3afoA:
undetectable		 5lf3b-3afoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 THR A 235
THR A 236
SER A 268
GLY A 267
ALA A 145
 None
 0.87A 5lf3b-3bjeA:
undetectable		 5lf3b-3bjeA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 THR A 263
LYS A 401
SER A 256
GLY A 257
THR A 363
 None
 1.19A 5lf3b-3dqqA:
undetectable		 5lf3b-3dqqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 THR A 241
THR A 245
THR A 246
SER A 224
ALA A 227
 None
 1.31A 5lf3b-3eexA:
undetectable		 5lf3b-3eexA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 THR A 245
THR A 246
SER A 224
GLY A 225
ALA A 227
 None
 1.23A 5lf3b-3eexA:
undetectable		 5lf3b-3eexA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		5 THR A 165
SER A 239
GLY A 238
ALA A  90
THR A 104
 None
 1.34A 5lf3b-3g10A:
undetectable		 5lf3b-3g10A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.29A 5lf3b-3gszA:
undetectable		 5lf3b-3gszA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		5 THR A 106
GLY A  94
ALA A  84
THR A  88
SER A  97
 None
 1.11A 5lf3b-3lm4A:
undetectable		 5lf3b-3lm4A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 6 LYS N  33
ARG N  45
GLY N  47
ALA N  49
THR N  52
SER N 129
 None
 1.45A 5lf3b-3mg6N:
34.2		 5lf3b-3mg6N:
53.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 5 THR N   1
ARG N  45
GLY N  98
THR N  52
SER N 131
 None
 1.09A 5lf3b-3mg6N:
34.2		 5lf3b-3mg6N:
53.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 11 THR N   1
THR N  20
THR N  21
THR N  22
LYS N  33
ARG N  45
SER N  46
GLY N  47
ALA N  49
THR N  52
SER N 168
 None
 0.57A 5lf3b-3mg6N:
34.2		 5lf3b-3mg6N:
53.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 6 THR N  20
ARG N  45
SER N  46
ALA N  49
THR N  52
SER N 169
 None
 1.41A 5lf3b-3mg6N:
34.2		 5lf3b-3mg6N:
53.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		5 THR A 413
THR A 412
GLY A 435
ALA A 466
THR A 437
 None
 1.40A 5lf3b-3muuA:
undetectable		 5lf3b-3muuA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqi PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		no annotation 5 THR A 118
THR A 119
SER A 114
GLY A 115
THR A 108
 None
 1.00A 5lf3b-3nqiA:
undetectable		 5lf3b-3nqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfw CELL-BINDING FACTOR
2

(Campylobacter
jejuni) 		PF13616
(Rotamase_3) 		5 THR A 209
THR A 211
THR A 212
THR A 213
ALA A 201
 None
 1.33A 5lf3b-3rfwA:
undetectable		 5lf3b-3rfwA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2

(Hordeum vulgare) 		PF00155
(Aminotran_1_2) 		5 SER A 131
GLY A 128
ALA A 126
MET A 347
SER A 274
 None
 1.35A 5lf3b-3tcmA:
undetectable		 5lf3b-3tcmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unf PROTEASOME SUBUNIT
BETA TYPE-10

(Mus musculus) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
THR H  21
LYS H  33
GLY H  47
ALA H  49
THR H  52
 04C  H 301 (-2.5A)
04C  H 301 (-3.9A)
04C  H 301 (-3.5A)
04C  H 301 (-3.7A)
04C  H 301 (-3.6A)
04C  H 301 (-3.8A)
 0.58A 5lf3b-3unfH:
30.6		 5lf3b-3unfH:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 THR A 425
THR A 412
SER A 283
GLY A 286
ALA A 280
 None
 1.34A 5lf3b-3vm7A:
undetectable		 5lf3b-3vm7A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 THR C  68
SER C 162
GLY C 163
ALA C  98
THR C  94
 None
 1.18A 5lf3b-3vtiC:
undetectable		 5lf3b-3vtiC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR L   2
THR L   1
SER L 174
GLY L 173
ALA L 165
 None
 0.93A 5lf3b-3wxrL:
28.5		 5lf3b-3wxrL:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 THR A 244
THR A 266
SER A 237
GLY A 238
ALA A 172
 None
 1.27A 5lf3b-3znyA:
undetectable		 5lf3b-3znyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dez DNA POLYMERASE IV 1

(Mycolicibacterium
smegmatis) 		PF00817
(IMS) 		5 THR A 200
THR A 191
THR A 190
GLY A 198
ALA A 196
 None
 1.38A 5lf3b-4dezA:
undetectable		 5lf3b-4dezA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt5 ANTIFREEZE PROTEIN

(Rhagium
inquisitor) 		no annotation 5 THR A 132
THR A  86
THR A  88
SER A  98
ALA A  73
 None
 1.40A 5lf3b-4dt5A:
undetectable		 5lf3b-4dt5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 THR A 151
THR A   6
ALA A 148
THR A   0
SER A 182
 None
 1.34A 5lf3b-4e3aA:
undetectable		 5lf3b-4e3aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF02230
(Abhydrolase_2) 		5 THR A 141
THR A 123
THR A 125
SER A 116
GLY A 118
 None
 1.29A 5lf3b-4f21A:
undetectable		 5lf3b-4f21A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l08 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		no annotation 5 THR B  68
THR B  69
GLY B 143
THR B  51
SER B 121
 None
 1.32A 5lf3b-4l08B:
undetectable		 5lf3b-4l08B:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		5 THR A  85
SER A  11
GLY A  10
ALA A  76
THR A  18
 None
FMN  A 201 (-2.4A)
None
None
FMN  A 201 (-3.6A)
 1.39A 5lf3b-4ltmA:
undetectable		 5lf3b-4ltmA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy7 PUTATIVE SECRETED
CELLULOSE BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		5 THR A 126
ARG A 200
SER A 201
GLY A 202
ALA A 204
 None
 1.40A 5lf3b-4oy7A:
undetectable		 5lf3b-4oy7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		5 THR A  27
THR A  26
THR A  25
GLY A  32
MET A  89
 None
 1.40A 5lf3b-4pfsA:
undetectable		 5lf3b-4pfsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pjs PENTATRICOPEPTIDE
REPEAT PROTEIN

(unidentified) 		PF13041
(PPR_2) 		5 THR A 148
SER A 116
GLY A 119
ALA A 127
SER A 151
 None
 1.27A 5lf3b-4pjsA:
undetectable		 5lf3b-4pjsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE

(Bacteroides
fragilis) 		PF13472
(Lipase_GDSL_2) 		5 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.40A 5lf3b-4ppyA:
undetectable		 5lf3b-4ppyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
THR K  21
LYS K  33
GLY K  47
ALA K  49
 None
 0.65A 5lf3b-4qv9K:
28.6		 5lf3b-4qv9K:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 174
GLY K 173
ALA K 165
 None
 0.97A 5lf3b-4qv9K:
28.6		 5lf3b-4qv9K:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		5 THR A 113
THR A 114
THR A 115
SER A 252
ALA A 309
 None
 1.34A 5lf3b-4r7fA:
undetectable		 5lf3b-4r7fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 THR A  70
SER A 172
GLY A 173
ALA A 160
THR A 161
 None
 1.27A 5lf3b-4ryeA:
undetectable		 5lf3b-4ryeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		5 THR A 338
THR A  18
THR A  19
SER A 329
GLY A 320
 None
None
None
None
FAD  A1355 (-4.4A)
 1.20A 5lf3b-4usrA:
undetectable		 5lf3b-4usrA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 THR A 324
THR A 285
GLY A 312
ALA A 270
THR A 269
 None
None
FMN  A 602 ( 4.8A)
None
None
 1.32A 5lf3b-4z9rA:
undetectable		 5lf3b-4z9rA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 THR A 214
THR A 216
THR A 217
ARG A 501
THR A 502
 None
 1.14A 5lf3b-5az4A:
undetectable		 5lf3b-5az4A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		5 THR A 220
THR A 241
SER A 214
GLY A 215
ALA A 149
 None
 1.27A 5lf3b-5e2eA:
undetectable		 5lf3b-5e2eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
THR H  21
LYS H  33
GLY H  47
ALA H  49
THR H  52
 None
 0.48A 5lf3b-5fg9H:
28.1		 5lf3b-5fg9H:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 THR I   1
THR I  21
LYS I  33
GLY I  47
ALA I  49
 7F1  I 300 (-2.7A)
None
7F1  I 300 (-4.7A)
7F1  I 300 (-3.8A)
7F1  I 300 (-3.5A)
 0.89A 5lf3b-5fmgI:
28.5		 5lf3b-5fmgI:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		5 THR A  65
THR A  64
SER A  82
GLY A  56
THR A  54
 None
 1.40A 5lf3b-5jcdA:
undetectable		 5lf3b-5jcdA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 THR A  31
THR A  86
SER A 116
GLY A 117
ALA A  94
 None
 1.15A 5lf3b-5jxlA:
undetectable		 5lf3b-5jxlA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
THR K  21
LYS K  33
GLY K  47
ALA K  49
 None
 0.83A 5lf3b-5l5wK:
28.5		 5lf3b-5l5wK:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
 None
 0.91A 5lf3b-5l5wK:
28.5		 5lf3b-5l5wK:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 THR A 222
THR A 475
THR A 474
GLY A  14
ALA A  16
 None
FAD  A1801 (-3.2A)
FAD  A1801 (-4.3A)
FAD  A1801 (-3.3A)
FAD  A1801 (-3.2A)
 1.26A 5lf3b-5laeA:
undetectable		 5lf3b-5laeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
LYS K  33
SER K  46
GLY K  47
ALA K  49
 7DX  K 301 (-3.3A)
7DX  K 301 (-4.2A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
 0.43A 5lf3b-5m2bK:
28.8		 5lf3b-5m2bK:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
 None
7DX  K 301 (-3.3A)
None
None
MG  K 302 (-4.8A)
 0.95A 5lf3b-5m2bK:
28.8		 5lf3b-5m2bK:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 THR A 334
ARG A 447
SER A 340
GLY A 344
ALA A 350
 CA  A 813 (-3.6A)
None
CA  A 813 (-2.3A)
None
None
 1.40A 5lf3b-5mfaA:
undetectable		 5lf3b-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 813 (-3.6A)
None
None
CA  A 813 (-2.3A)
None
 1.27A 5lf3b-5mfaA:
undetectable		 5lf3b-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		6 THR A   1
THR A  20
LYS A  32
GLY A  50
THR A  55
SER A 190
 None
 1.11A 5lf3b-5nyjA:
21.6		 5lf3b-5nyjA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 THR A 458
THR A 483
ARG A 505
GLY A 489
MET A 545
 None
 1.22A 5lf3b-5o7eA:
undetectable		 5lf3b-5o7eA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovt BPH

(Thiobacillus
denitrificans) 		no annotation 5 THR A   1
THR A  20
LYS A  37
GLY A  50
ALA A  52
 PO4  A 301 ( 4.5A)
None
None
PO4  A 301 (-4.1A)
None
 0.46A 5lf3b-5ovtA:
17.0		 5lf3b-5ovtA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		no annotation 5 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.74A 5lf3b-5vfrR:
27.1		 5lf3b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 THR A 120
SER A 172
GLY A 174
THR A 129
MET A  79
 None
 1.28A 5lf3b-5vm1A:
undetectable		 5lf3b-5vm1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		5 THR A 187
THR A 158
GLY A 102
ALA A 100
SER A 183
 None
 1.27A 5lf3b-5wueA:
undetectable		 5lf3b-5wueA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 5 THR A 199
THR A 198
GLY A 204
THR A 228
SER A 298
 None
 1.36A 5lf3b-5ysbA:
undetectable		 5lf3b-5ysbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh6 -

(-) 		no annotation 5 THR A  80
SER A  89
GLY A  87
ALA A  85
MET A 103
 None
 1.39A 5lf3b-5zh6A:
undetectable		 5lf3b-5zh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 5 THR A 408
THR A 407
GLY A 411
ALA A  92
THR A  88
 None
 1.25A 5lf3b-5zovA:
undetectable		 5lf3b-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 5 THR C   1
LYS C  33
SER C  46
GLY C  47
ALA C  49
 BZ7  C 301 (-4.0A)
BZ7  C 301 ( 4.8A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
 0.64A 5lf3b-6avoC:
28.8		 5lf3b-6avoC:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-9

(Homo sapiens) 		no annotation 6 THR A   1
LYS A  33
SER A  46
GLY A  47
ALA A  49
SER A 168
 None
 0.61A 5lf3b-6avoA:
26.1		 5lf3b-6avoA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 806 (-3.6A)
None
None
CA  A 806 (-1.9A)
None
 1.31A 5lf3b-6azpA:
undetectable		 5lf3b-6azpA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 THR A 244
THR A 266
SER A 237
GLY A 238
ALA A 172
 3GK  A 302 ( 4.9A)
None
3GK  A 301 ( 2.7A)
3GK  A 301 (-3.6A)
None
 1.25A 5lf3b-6bu3A:
undetectable		 5lf3b-6bu3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 5 ARG A 676
SER A 710
ALA A 646
THR A 659
SER A 253
 None
 1.36A 5lf3b-6eksA:
undetectable		 5lf3b-6eksA:
14.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6epd PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 5 THR 1  35
THR 1  54
THR 1  55
ALA 1  83
SER 1 203
 None
 1.20A 5lf3b-6epd1:
24.6		 5lf3b-6epd1:
97.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7

(Saccharomyces
cerevisiae) 		no annotation 5 THR O  94
THR O  93
SER Q  74
GLY Q  73
ALA O  61
 None
 1.35A 5lf3b-6eu2O:
undetectable		 5lf3b-6eu2O:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 5 THR A  80
THR A  84
GLY A  51
ALA A  57
THR A  60
 FAD  A 701 ( 4.3A)
None
FAD  A 701 ( 4.9A)
None
None
 1.22A 5lf3b-6fnuA:
undetectable		 5lf3b-6fnuA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 THR L 404
THR L 275
THR L 276
ALA L 282
THR L 412
 None
 1.23A 5lf3b-6g2jL:
undetectable		 5lf3b-6g2jL:
16.24