SIMILAR PATTERNS OF AMINO ACIDS FOR 5LAK_I_BEZI1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 SER A 327
TYR A 326
TYR A 325
 None
 0.80A 5lakA-1cbgA:
0.0
5lakI-1cbgA:
undetectable		 5lakA-1cbgA:
20.17
5lakI-1cbgA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cks CYCLIN-DEPENDENT
KINASE SUBUNIT, TYPE
2

(Homo sapiens) 		PF01111
(CKS) 		3 SER A   9
TYR A   8
TYR A   7
 None
 0.89A 5lakA-1cksA:
undetectable
5lakI-1cksA:
undetectable		 5lakA-1cksA:
13.99
5lakI-1cksA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis) 		PF00182
(Glyco_hydro_19) 		3 SER A 109
TYR A  97
TYR A 110
 None
 0.86A 5lakA-1dxjA:
undetectable
5lakI-1dxjA:
undetectable		 5lakA-1dxjA:
18.96
5lakI-1dxjA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1s P-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		3 SER A  46
TYR A  45
TYR A  44
 None
 0.70A 5lakA-1g1sA:
0.0
5lakI-1g1sA:
undetectable		 5lakA-1g1sA:
15.31
5lakI-1g1sA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		3 SER A 310
TYR A 309
TYR A 308
 None
 0.78A 5lakA-1gnxA:
0.0
5lakI-1gnxA:
undetectable		 5lakA-1gnxA:
20.35
5lakI-1gnxA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 SER J 103
TYR J 102
TYR J 101
 None
 0.81A 5lakA-1kyoJ:
0.6
5lakI-1kyoJ:
undetectable		 5lakA-1kyoJ:
15.48
5lakI-1kyoJ:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 SER A  37
TYR A  36
TYR A  35
 None
 0.00A 5lakA-1q5aA:
0.0
5lakI-1q5aA:
undetectable		 5lakA-1q5aA:
15.02
5lakI-1q5aA:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 SER A 322
TYR A 321
TYR A 320
 None
 0.76A 5lakA-1qvbA:
0.0
5lakI-1qvbA:
undetectable		 5lakA-1qvbA:
19.17
5lakI-1qvbA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toc ORNITHODORIN

(Ornithodoros
moubata) 		no annotation 3 SER R  42
TYR R  40
TYR R  22
 None
 0.80A 5lakA-1tocR:
0.0
5lakI-1tocR:
undetectable		 5lakA-1tocR:
16.56
5lakI-1tocR:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		3 SER A 297
TYR A 296
TYR A 295
 None
GOL  A2000 (-4.0A)
None
 0.68A 5lakA-1tr1A:
0.0
5lakI-1tr1A:
undetectable		 5lakA-1tr1A:
20.76
5lakI-1tr1A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A  10
TYR A   9
TYR A  56
 None
 0.40A 5lakA-1uufA:
0.0
5lakI-1uufA:
undetectable		 5lakA-1uufA:
20.51
5lakI-1uufA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		3 SER A 321
TYR A 317
TYR A 316
 None
 0.84A 5lakA-1v5cA:
undetectable
5lakI-1v5cA:
undetectable		 5lakA-1v5cA:
22.11
5lakI-1v5cA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqk TOXIN APETX1

(Anthopleura
elegantissima) 		PF07936
(Defensin_4) 		3 SER A  29
TYR A  26
TYR A  39
 None
 0.86A 5lakA-1wqkA:
undetectable
5lakI-1wqkA:
undetectable		 5lakA-1wqkA:
8.04
5lakI-1wqkA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 SER A 249
TYR A 272
TYR A 247
 None
 0.87A 5lakA-1xeuA:
undetectable
5lakI-1xeuA:
undetectable		 5lakA-1xeuA:
22.98
5lakI-1xeuA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1

(Homo sapiens) 		PF01111
(CKS) 		3 SER C3009
TYR C3008
TYR C3007
 None
 0.74A 5lakA-2astC:
undetectable
5lakI-2astC:
undetectable		 5lakA-2astC:
11.80
5lakI-2astC:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 SER B 462
TYR B 461
TYR B 401
 None
 0.84A 5lakA-2c6wB:
undetectable
5lakI-2c6wB:
undetectable		 5lakA-2c6wB:
22.95
5lakI-2c6wB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9a RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00047
(ig)
PF00629
(MAM) 		3 SER A  39
TYR A  38
TYR A  33
 None
 0.86A 5lakA-2c9aA:
undetectable
5lakI-2c9aA:
undetectable		 5lakA-2c9aA:
21.15
5lakI-2c9aA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckb ALPHA, BETA T CELL
RECEPTOR

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 SER A  51
TYR A  50
TYR A  49
 None
 0.62A 5lakA-2ckbA:
undetectable
5lakI-2ckbA:
undetectable		 5lakA-2ckbA:
20.90
5lakI-2ckbA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 SER A 423
TYR A 422
TYR A 434
 None
 0.77A 5lakA-2e5vA:
undetectable
5lakI-2e5vA:
undetectable		 5lakA-2e5vA:
19.33
5lakI-2e5vA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 SER A 117
TYR A 495
TYR A 119
 None
 0.90A 5lakA-2e7zA:
undetectable
5lakI-2e7zA:
undetectable		 5lakA-2e7zA:
16.60
5lakI-2e7zA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		3 SER A 600
TYR A 599
TYR A 598
 None
TDK  A 887 (-4.3A)
None
 0.53A 5lakA-2g28A:
undetectable
5lakI-2g28A:
undetectable		 5lakA-2g28A:
16.07
5lakI-2g28A:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 SER A  64
TYR A  63
TYR A  62
 None
 0.79A 5lakA-2gb3A:
undetectable
5lakI-2gb3A:
undetectable		 5lakA-2gb3A:
20.91
5lakI-2gb3A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 SER A 205
TYR A 204
TYR A 203
 None
 0.66A 5lakA-2hv2A:
undetectable
5lakI-2hv2A:
undetectable		 5lakA-2hv2A:
18.45
5lakI-2hv2A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		3 SER A 248
TYR A 205
TYR A 204
 None
 0.81A 5lakA-2i62A:
undetectable
5lakI-2i62A:
undetectable		 5lakA-2i62A:
22.43
5lakI-2i62A:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		3 SER A 426
TYR A 425
TYR A 408
 None
 0.81A 5lakA-2i7nA:
undetectable
5lakI-2i7nA:
undetectable		 5lakA-2i7nA:
21.08
5lakI-2i7nA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		3 SER A 143
TYR A 142
TYR A 155
 None
 0.86A 5lakA-2ij9A:
undetectable
5lakI-2ij9A:
undetectable		 5lakA-2ij9A:
21.24
5lakI-2ij9A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 SER A 296
TYR A 295
TYR A 294
 None
IDE  A1446 (-3.5A)
None
 0.74A 5lakA-2j7cA:
undetectable
5lakI-2j7cA:
undetectable		 5lakA-2j7cA:
21.79
5lakI-2j7cA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		3 SER A  72
TYR A  71
TYR A  53
 None
 0.90A 5lakA-2myiA:
undetectable
5lakI-2myiA:
undetectable		 5lakA-2myiA:
20.19
5lakI-2myiA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 SER A  55
TYR A  56
TYR A 481
 None
 0.82A 5lakA-2oaeA:
0.8
5lakI-2oaeA:
undetectable		 5lakA-2oaeA:
18.91
5lakI-2oaeA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgc UNCHARACTERIZED
PROTEIN

(uncultured
marine organism) 		no annotation 3 SER A 171
TYR A 169
TYR A 114
 None
 0.85A 5lakA-2pgcA:
0.5
5lakI-2pgcA:
undetectable		 5lakA-2pgcA:
20.48
5lakI-2pgcA:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		3 SER A 141
TYR A 142
TYR A 143
 None
 0.90A 5lakA-2qqhA:
undetectable
5lakI-2qqhA:
undetectable		 5lakA-2qqhA:
20.55
5lakI-2qqhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0q PUTATIVE TRANSPOSON
TN552 DNA-INVERTASE
BIN3

(Staphylococcus
aureus) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		3 SER C 153
TYR C 152
TYR C 165
 None
 0.87A 5lakA-2r0qC:
undetectable
5lakI-2r0qC:
undetectable		 5lakA-2r0qC:
22.22
5lakI-2r0qC:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlw MUSCARINIC M1-TOXIN1

(Dendroaspis
angusticeps) 		PF00087
(Toxin_TOLIP) 		3 SER A  32
TYR A  36
TYR A  30
 None
None
TYI  A  51 ( 4.6A)
 0.91A 5lakA-2vlwA:
undetectable
5lakI-2vlwA:
undetectable		 5lakA-2vlwA:
13.91
5lakI-2vlwA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz4 HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR TIPA

(Streptomyces
lividans) 		PF13411
(MerR_1) 		3 SER A  42
TYR A  41
TYR A   3
 None
 0.76A 5lakA-2vz4A:
undetectable
5lakI-2vz4A:
undetectable		 5lakA-2vz4A:
15.53
5lakI-2vz4A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 SER A  74
TYR A  73
TYR A 429
 None
 0.71A 5lakA-2xijA:
undetectable
5lakI-2xijA:
undetectable		 5lakA-2xijA:
17.52
5lakI-2xijA:
1.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		3 SER A 342
TYR A 341
TYR A 340
 None
 0.78A 5lakA-2yqhA:
undetectable
5lakI-2yqhA:
undetectable		 5lakA-2yqhA:
19.80
5lakI-2yqhA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysp ZINC FINGER PROTEIN
224

(Homo sapiens) 		no annotation 3 SER A  24
TYR A  22
TYR A  13
 None
 0.80A 5lakA-2yspA:
undetectable
5lakI-2yspA:
undetectable		 5lakA-2yspA:
10.74
5lakI-2yspA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf3 HYPOTHETICAL PROTEIN
VIOE

(Chromobacterium
violaceum) 		no annotation 3 SER A  15
TYR A  17
TYR A  34
 None
 0.73A 5lakA-2zf3A:
undetectable
5lakI-2zf3A:
undetectable		 5lakA-2zf3A:
22.15
5lakI-2zf3A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bid UPF0339 PROTEIN
NMB1088

(Neisseria
meningitidis) 		PF07411
(DUF1508) 		3 SER A  33
TYR A  31
TYR A  13
 None
 0.90A 5lakA-3bidA:
undetectable
5lakI-3bidA:
undetectable		 5lakA-3bidA:
12.74
5lakI-3bidA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A 195
TYR A 175
TYR A 176
 None
 0.90A 5lakA-3dkhA:
undetectable
5lakI-3dkhA:
undetectable		 5lakA-3dkhA:
19.58
5lakI-3dkhA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		3 SER A 198
TYR A 197
TYR A 196
 None
 0.80A 5lakA-3dwkA:
undetectable
5lakI-3dwkA:
undetectable		 5lakA-3dwkA:
20.14
5lakI-3dwkA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3q T-CELL RECEPTOR
ALPHA CHAIN V REGION
PHDS58

(Mus musculus) 		no annotation 3 SER D  51
TYR D  50
TYR D  49
 None
 0.71A 5lakA-3e3qD:
undetectable
5lakI-3e3qD:
undetectable		 5lakA-3e3qD:
14.47
5lakI-3e3qD:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1b TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 SER A  55
TYR A  53
TYR A  50
 None
 0.91A 5lakA-3f1bA:
undetectable
5lakI-3f1bA:
undetectable		 5lakA-3f1bA:
18.07
5lakI-3f1bA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi7 LMO1076 PROTEIN

(Listeria
monocytogenes) 		PF01832
(Glucosaminidase) 		3 SER A 175
TYR A 173
TYR A 136
 None
 0.82A 5lakA-3fi7A:
undetectable
5lakI-3fi7A:
undetectable		 5lakA-3fi7A:
20.38
5lakI-3fi7A:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 SER A 398
TYR A 397
TYR A 413
 None
 0.80A 5lakA-3hagA:
undetectable
5lakI-3hagA:
undetectable		 5lakA-3hagA:
21.28
5lakI-3hagA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 SER A 105
TYR A 124
TYR A 123
 None
 0.57A 5lakA-3holA:
undetectable
5lakI-3holA:
undetectable		 5lakA-3holA:
21.36
5lakI-3holA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my2 LIPOPOLYSACCHARIDE
EXPORT SYSTEM
PROTEIN LPTC

(Escherichia
coli) 		PF06835
(LptC) 		3 SER A  71
TYR A  70
TYR A  69
 None
 0.75A 5lakA-3my2A:
undetectable
5lakI-3my2A:
undetectable		 5lakA-3my2A:
18.73
5lakI-3my2A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 SER A 418
TYR A 417
TYR A 416
 HP8  A 601 ( 4.6A)
None
None
 0.84A 5lakA-3o82A:
undetectable
5lakI-3o82A:
undetectable		 5lakA-3o82A:
19.78
5lakI-3o82A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A 196
TYR A 176
TYR A 177
 None
 0.85A 5lakA-3ppsA:
undetectable
5lakI-3ppsA:
undetectable		 5lakA-3ppsA:
20.33
5lakI-3ppsA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 SER A 112
TYR A 131
TYR A 130
 None
 0.75A 5lakA-3pqsA:
undetectable
5lakI-3pqsA:
undetectable		 5lakA-3pqsA:
19.85
5lakI-3pqsA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 SER A 130
TYR A 162
TYR A 161
 None
 0.54A 5lakA-3pquA:
undetectable
5lakI-3pquA:
undetectable		 5lakA-3pquA:
19.76
5lakI-3pquA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tf7 42F3 MUT7 SCFV (42F3
ALPHA CHAIN, LINKER,
42F3 BETA CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 SER C  51
TYR C  50
TYR C  49
 None
 0.50A 5lakA-3tf7C:
undetectable
5lakI-3tf7C:
undetectable		 5lakA-3tf7C:
21.84
5lakI-3tf7C:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpu 42F3 ALPHA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 SER A  51
TYR A  50
TYR A  49
 None
 0.63A 5lakA-3tpuA:
undetectable
5lakI-3tpuA:
undetectable		 5lakA-3tpuA:
21.36
5lakI-3tpuA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 SER A 224
TYR A 223
TYR A 222
 None
 0.73A 5lakA-3vtrA:
undetectable
5lakI-3vtrA:
undetectable		 5lakA-3vtrA:
18.51
5lakI-3vtrA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		3 SER A 242
TYR A 240
TYR A 202
 None
 0.80A 5lakA-3vwoA:
undetectable
5lakI-3vwoA:
undetectable		 5lakA-3vwoA:
17.98
5lakI-3vwoA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		3 SER A 308
TYR A 307
TYR A 306
 None
 0.75A 5lakA-3wq8A:
undetectable
5lakI-3wq8A:
undetectable		 5lakA-3wq8A:
19.57
5lakI-3wq8A:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		3 SER A 271
TYR A 270
TYR A 426
 None
 0.90A 5lakA-3x0uA:
undetectable
5lakI-3x0uA:
undetectable		 5lakA-3x0uA:
21.13
5lakI-3x0uA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		3 SER A 362
TYR A 361
TYR A 360
 None
 0.79A 5lakA-4bmaA:
undetectable
5lakI-4bmaA:
undetectable		 5lakA-4bmaA:
18.98
5lakI-4bmaA:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		3 SER A 162
TYR A 163
TYR A 166
 None
 0.71A 5lakA-4bmrA:
undetectable
5lakI-4bmrA:
undetectable		 5lakA-4bmrA:
21.55
5lakI-4bmrA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0z ANCILLARY PROTEIN 2

(Streptococcus
pyogenes) 		PF08341
(TED) 		3 SER A  33
TYR A  36
TYR A  39
 None
 0.90A 5lakA-4c0zA:
undetectable
5lakI-4c0zA:
undetectable		 5lakA-4c0zA:
22.09
5lakI-4c0zA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus) 		PF03446
(NAD_binding_2) 		3 SER A 155
TYR A 154
TYR A 176
 None
 0.76A 5lakA-4d3dA:
undetectable
5lakI-4d3dA:
undetectable		 5lakA-4d3dA:
21.18
5lakI-4d3dA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 SER A 121
TYR A 140
TYR A 141
 None
 0.71A 5lakA-4dweA:
undetectable
5lakI-4dweA:
undetectable		 5lakA-4dweA:
21.15
5lakI-4dweA:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fab IGG2A-KAPPA 4-4-20
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  63
TYR H  62
TYR H  61
 None
 0.66A 5lakA-4fabH:
undetectable
5lakI-4fabH:
undetectable		 5lakA-4fabH:
20.25
5lakI-4fabH:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn2 ANTI DABIGATRAN FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 103
TYR B 102
TYR B 101
 None
 0.52A 5lakA-4jn2B:
undetectable
5lakI-4jn2B:
undetectable		 5lakA-4jn2B:
21.84
5lakI-4jn2B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 SER A 639
TYR A 607
TYR A 608
 None
 0.78A 5lakA-4k3cA:
undetectable
5lakI-4k3cA:
undetectable		 5lakA-4k3cA:
19.35
5lakI-4k3cA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 SER A 436
TYR A 437
TYR A 371
 IOD  A 723 ( 4.2A)
None
None
 0.54A 5lakA-4kcaA:
0.7
5lakI-4kcaA:
undetectable		 5lakA-4kcaA:
18.94
5lakI-4kcaA:
0.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		3 SER A 208
TYR A 207
TYR A 206
 None
 0.58A 5lakA-4lxiA:
0.7
5lakI-4lxiA:
undetectable		 5lakA-4lxiA:
19.41
5lakI-4lxiA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 SER A 319
TYR A 298
TYR A 317
 None
 0.77A 5lakA-4mbrA:
undetectable
5lakI-4mbrA:
undetectable		 5lakA-4mbrA:
22.91
5lakI-4mbrA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3x TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		3 SER B 105
TYR B 124
TYR B 123
 None
 0.71A 5lakA-4o3xB:
undetectable
5lakI-4o3xB:
undetectable		 5lakA-4o3xB:
22.77
5lakI-4o3xB:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		3 SER A  12
TYR A  11
TYR A   7
 None
 0.69A 5lakA-4o6qA:
undetectable
5lakI-4o6qA:
undetectable		 5lakA-4o6qA:
19.43
5lakI-4o6qA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546) 		PF03446
(NAD_binding_2) 		3 SER A 136
TYR A 135
TYR A 157
 None
 0.77A 5lakA-4oqyA:
undetectable
5lakI-4oqyA:
undetectable		 5lakA-4oqyA:
21.97
5lakI-4oqyA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR

(Streptomyces
aurantiacus) 		PF03446
(NAD_binding_2) 		3 SER A 135
TYR A 134
TYR A 157
 None
 0.77A 5lakA-4oqzA:
undetectable
5lakI-4oqzA:
undetectable		 5lakA-4oqzA:
24.50
5lakI-4oqzA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 SER A 297
TYR A 296
TYR A 295
 None
BGC  A 501 (-4.1A)
None
 0.78A 5lakA-4ptxA:
undetectable
5lakI-4ptxA:
undetectable		 5lakA-4ptxA:
22.48
5lakI-4ptxA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 SER A 124
TYR A 151
TYR A 150
 None
 0.78A 5lakA-4qq1A:
undetectable
5lakI-4qq1A:
undetectable		 5lakA-4qq1A:
19.82
5lakI-4qq1A:
2.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvc ABC TRANSPORTER
ATP-BINDING PROTEIN

(Geobacillus
kaustophilus) 		PF00005
(ABC_tran) 		3 SER A  61
TYR A  65
TYR A  74
 None
 0.91A 5lakA-4rvcA:
undetectable
5lakI-4rvcA:
undetectable		 5lakA-4rvcA:
20.86
5lakI-4rvcA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		3 SER A1129
TYR A1127
TYR A1151
 None
 0.62A 5lakA-4tsmA:
undetectable
5lakI-4tsmA:
undetectable		 5lakA-4tsmA:
19.62
5lakI-4tsmA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 PUTATIVE CYSTINE
PROTEASE

(Pseudomonas
fluorescens) 		PF06035
(Peptidase_C93) 		3 SER E 177
TYR E 176
TYR E 175
 None
 0.72A 5lakA-4u65E:
undetectable
5lakI-4u65E:
undetectable		 5lakA-4u65E:
18.93
5lakI-4u65E:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		3 SER A 189
TYR A 188
TYR A 187
 FON  A 402 ( 4.6A)
None
None
 0.88A 5lakA-4xd0A:
undetectable
5lakI-4xd0A:
undetectable		 5lakA-4xd0A:
22.54
5lakI-4xd0A:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA

(Homo sapiens) 		PF00017
(SH2) 		3 SER A 690
TYR A 688
TYR A 679
 None
 0.69A 5lakA-5aulA:
undetectable
5lakI-5aulA:
undetectable		 5lakA-5aulA:
16.61
5lakI-5aulA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16585
(Lipocalin_8) 		3 SER A  61
TYR A  79
TYR A  80
 None
 0.68A 5lakA-5bypA:
undetectable
5lakI-5bypA:
undetectable		 5lakA-5bypA:
16.14
5lakI-5bypA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 SER A 166
TYR A 167
TYR A 117
 None
 0.62A 5lakA-5ck0A:
undetectable
5lakI-5ck0A:
undetectable		 5lakA-5ck0A:
19.54
5lakI-5ck0A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		3 SER A 241
TYR A 239
TYR A 201
 IOD  A 401 ( 4.9A)
None
None
 0.76A 5lakA-5dn5A:
undetectable
5lakI-5dn5A:
undetectable		 5lakA-5dn5A:
18.15
5lakI-5dn5A:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		3 SER A 401
TYR A 400
TYR A 383
 None
 0.69A 5lakA-5e26A:
undetectable
5lakI-5e26A:
undetectable		 5lakA-5e26A:
22.02
5lakI-5e26A:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 SER A 339
TYR A 338
TYR A 337
 None
 0.87A 5lakA-5e76A:
undetectable
5lakI-5e76A:
undetectable		 5lakA-5e76A:
20.93
5lakI-5e76A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		3 SER A 135
TYR A 134
TYR A 157
 None
 0.72A 5lakA-5g6rA:
undetectable
5lakI-5g6rA:
undetectable		 5lakA-5g6rA:
19.64
5lakI-5g6rA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hda ZINC FINGER MYND
DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		no annotation 3 SER A 542
TYR A 540
TYR A 532
 ZN  A 602 ( 4.3A)
None
None
 0.54A 5lakA-5hdaA:
undetectable
5lakI-5hdaA:
undetectable		 5lakA-5hdaA:
15.26
5lakI-5hdaA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hec PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF00535
(Glycos_transf_2) 		3 SER A 212
TYR A 213
TYR A 214
 None
 0.90A 5lakA-5hecA:
undetectable
5lakI-5hecA:
undetectable		 5lakA-5hecA:
21.27
5lakI-5hecA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		3 SER A 294
TYR A 293
TYR A 292
 ACT  A 502 (-2.8A)
ACT  A 501 ( 4.8A)
None
 0.81A 5lakA-5idiA:
undetectable
5lakI-5idiA:
undetectable		 5lakA-5idiA:
22.07
5lakI-5idiA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 SER A 457
TYR A 456
TYR A 138
 None
 0.78A 5lakA-5jp0A:
undetectable
5lakI-5jp0A:
undetectable		 5lakA-5jp0A:
17.51
5lakI-5jp0A:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 3 SER A 206
TYR A 205
TYR A 204
 None
 0.78A 5lakA-5mlgA:
undetectable
5lakI-5mlgA:
undetectable		 5lakA-5mlgA:
undetectable
5lakI-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 3 SER A1332
TYR A1331
TYR A1330
 None
 0.65A 5lakA-5ngyA:
undetectable
5lakI-5ngyA:
undetectable		 5lakA-5ngyA:
13.44
5lakI-5ngyA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntb PAPAIN INHIBITOR

(Streptomyces
mobaraensis) 		no annotation 3 SER A  86
TYR A  14
TYR A  15
 None
 0.83A 5lakA-5ntbA:
undetectable
5lakI-5ntbA:
undetectable		 5lakA-5ntbA:
undetectable
5lakI-5ntbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 3 SER A 136
TYR A 135
TYR A 158
 None
 0.90A 5lakA-5ocmA:
undetectable
5lakI-5ocmA:
undetectable		 5lakA-5ocmA:
undetectable
5lakI-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica) 		PF00551
(Formyl_trans_N)
PF13637
(Ank_4) 		3 SER A 189
TYR A 188
TYR A 187
 None
 0.76A 5lakA-5uinA:
undetectable
5lakI-5uinA:
undetectable		 5lakA-5uinA:
21.95
5lakI-5uinA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A 277
TYR A 276
TYR A 275
 None
 0.66A 5lakA-5vdkA:
undetectable
5lakI-5vdkA:
undetectable		 5lakA-5vdkA:
19.44
5lakI-5vdkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 3 SER B 275
TYR B 274
TYR B 246
 None
 0.77A 5lakA-5wwpB:
undetectable
5lakI-5wwpB:
undetectable		 5lakA-5wwpB:
19.87
5lakI-5wwpB:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 3 SER A 153
TYR A 151
TYR A 148
 None
 0.82A 5lakA-5zb8A:
undetectable
5lakI-5zb8A:
undetectable		 5lakA-5zb8A:
undetectable
5lakI-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w CENTROMERE PROTEIN N

(Homo sapiens) 		no annotation 3 SER K 156
TYR K 155
TYR K 154
 SER  K 156 ( 0.0A)
TYR  K 155 ( 1.3A)
TYR  K 154 ( 1.3A)
 0.76A 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable		 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 3 SER A 100
TYR A  99
TYR A 248
 None
 0.53A 5lakA-6eheA:
undetectable
5lakI-6eheA:
undetectable		 5lakA-6eheA:
undetectable
5lakI-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqt CENTROMERE PROTEIN N

(Homo sapiens) 		no annotation 3 SER A 156
TYR A 155
TYR A 154
 None
 0.65A 5lakA-6eqtA:
undetectable
5lakI-6eqtA:
undetectable		 5lakA-6eqtA:
undetectable
5lakI-6eqtA:
undetectable