SIMILAR PATTERNS OF AMINO ACIDS FOR 5L94_A_TESA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5f MONOCLONAL
ANTI-E-SELECTIN 7A9
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 197
ILE H 214
ALA H 132
VAL H 143
VAL H 190
 None
 1.43A 5l94A-1a5fH:
0.0		 5l94A-1a5fH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 VAL A 246
ILE A 234
ALA A 230
VAL A 150
VAL A 148
 None
 1.23A 5l94A-1bh6A:
0.0		 5l94A-1bh6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 VAL A 246
ILE A 234
ALA A 232
VAL A 150
VAL A 148
 None
 1.29A 5l94A-1bh6A:
0.0		 5l94A-1bh6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 VAL A 246
ILE A 234
ALA A 230
VAL A 150
VAL A 148
 None
 1.16A 5l94A-1c3lA:
0.0		 5l94A-1c3lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 VAL A 246
ILE A 234
ALA A 232
VAL A 150
VAL A 148
 None
 1.25A 5l94A-1c3lA:
0.0		 5l94A-1c3lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 VAL L 486
ILE L 464
ALA L 452
HIS L 378
VAL L  22
 None
 1.42A 5l94A-1cc1L:
0.0		 5l94A-1cc1L:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 VAL A 137
ILE A 175
ALA A 176
VAL A 190
VAL A 242
 None
 1.06A 5l94A-1cnzA:
0.0		 5l94A-1cnzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 VAL A  28
ILE A  24
ALA A  21
HIS A 306
VAL A  30
 None
 1.41A 5l94A-1dkrA:
0.0		 5l94A-1dkrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE B 286
THR B 343
VAL B 545
HIS B 535
VAL B 538
 None
 1.39A 5l94A-1e9yB:
0.0		 5l94A-1e9yB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehl ANTI-(6-4)
PHOTOPRODUCT
ANTIBODY 64M-2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 121
ALA H 118
THR H 217
VAL H 152
VAL H 210
 None
 1.46A 5l94A-1ehlH:
0.0		 5l94A-1ehlH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE

(Comamonas
testosteroni) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 VAL A 110
ILE A 183
ALA A 184
VAL A 166
HIS A 238
 None
 1.42A 5l94A-1fk8A:
0.0		 5l94A-1fk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		5 VAL A 177
ILE A 121
ALA A 124
VAL A 250
VAL A 246
 None
 1.26A 5l94A-1fwxA:
undetectable		 5l94A-1fwxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 VAL A 142
ILE A 138
ALA A 135
PHE A 151
VAL A 148
 None
 1.30A 5l94A-1g68A:
undetectable		 5l94A-1g68A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 VAL A 354
ILE A 328
ALA A 330
THR A 312
VAL A 357
 None
 1.49A 5l94A-1ggmA:
undetectable		 5l94A-1ggmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1grj GREA PROTEIN

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		5 VAL A  86
ILE A 131
ALA A 127
VAL A  94
VAL A  92
 None
 1.24A 5l94A-1grjA:
undetectable		 5l94A-1grjA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 VAL A  93
ILE A  42
VAL A 102
HIS A  99
VAL A 104
 None
 1.14A 5l94A-1gynA:
undetectable		 5l94A-1gynA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 VAL A 507
ILE A 468
ALA A 471
THR A 449
VAL A 500
 None
 1.42A 5l94A-1h39A:
undetectable		 5l94A-1h39A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 VAL A 452
ILE A 188
THR A 146
VAL A 150
VAL A 168
 None
 1.45A 5l94A-1hcyA:
undetectable		 5l94A-1hcyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)

(Escherichia
coli) 		PF02075
(RuvC) 		5 VAL A 106
ILE A 145
ALA A 142
VAL A 125
VAL A 121
 None
 1.14A 5l94A-1hjrA:
undetectable		 5l94A-1hjrA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwu PII PROTEIN

(Herbaspirillum
seropedicae) 		PF00543
(P-II) 		5 VAL A   4
ILE A  77
ALA A  76
VAL A  69
VAL A  70
 None
 1.22A 5l94A-1hwuA:
undetectable		 5l94A-1hwuA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igj IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 121
ALA B 118
THR B 217
VAL B 152
VAL B 210
 None
 1.40A 5l94A-1igjB:
undetectable		 5l94A-1igjB:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		4 ILE A 162
ALA A 163
VAL A 138
VAL A 407
 None
 0.39A 5l94A-1iokA:
undetectable		 5l94A-1iokA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 547
ILE A 544
ALA A 513
THR A 512
VAL A 597
 None
 1.44A 5l94A-1itzA:
undetectable		 5l94A-1itzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 VAL A 319
ILE A 316
ALA A  35
VAL A 245
VAL A 241
 None
 1.33A 5l94A-1j2bA:
undetectable		 5l94A-1j2bA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		5 VAL A   5
ILE A  16
VAL A  62
PHE A  30
VAL A  29
 None
 1.30A 5l94A-1j9lA:
undetectable		 5l94A-1j9lA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji4 NEUTROPHIL-ACTIVATIN
G PROTEIN A

(Helicobacter
pylori) 		PF00210
(Ferritin) 		5 VAL A  21
ILE A  43
ALA A  39
VAL A  28
PHE A  86
 None
MPD  A 700 ( 4.6A)
None
None
None
 1.29A 5l94A-1ji4A:
undetectable		 5l94A-1ji4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		5 VAL A 388
ILE A 326
VAL A 344
HIS A 383
VAL A 340
 None
 1.34A 5l94A-1kj9A:
undetectable		 5l94A-1kj9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo3 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		no annotation 5 VAL Y 127
ALA Y 124
THR Y 210
VAL Y 156
VAL Y 203
 None
 1.47A 5l94A-1lo3Y:
undetectable		 5l94A-1lo3Y:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 VAL A 273
ILE A 217
ALA A 216
VAL A 207
PHE A 276
 None
UD1  A 341 (-4.5A)
None
None
None
 1.34A 5l94A-1lrkA:
undetectable		 5l94A-1lrkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		5 VAL A 167
ILE A 208
ALA A 205
VAL A 322
VAL A 320
 None
 1.28A 5l94A-1lv7A:
undetectable		 5l94A-1lv7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2b [2FE-2S] FERREDOXIN

(Aquifex
aeolicus) 		no annotation 5 ALA A  33
VAL A  65
HIS A   5
PHE A   7
VAL A   8
 None
 1.21A 5l94A-1m2bA:
undetectable		 5l94A-1m2bA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		5 VAL A 339
ALA A 330
THR A 333
VAL A  17
VAL A 376
 None
 1.32A 5l94A-1mg7A:
undetectable		 5l94A-1mg7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		5 VAL A 339
ILE A 331
ALA A 330
VAL A  17
VAL A 376
 None
 1.25A 5l94A-1mg7A:
undetectable		 5l94A-1mg7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 VAL A 210
ILE A 245
ALA A 246
VAL A  99
VAL A 165
 None
 0.93A 5l94A-1mxfA:
undetectable		 5l94A-1mxfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 ILE A 425
ALA A 424
VAL A 555
PHE A 553
VAL A 554
 None
 1.05A 5l94A-1nbwA:
undetectable		 5l94A-1nbwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5i 3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		5 VAL A 169
ILE A 206
ALA A 207
VAL A  74
VAL A 124
 None
 0.86A 5l94A-1o5iA:
undetectable		 5l94A-1o5iA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		5 VAL D 812
ILE D 818
VAL D 766
HIS D 751
VAL D 783
 None
 1.32A 5l94A-1pytD:
undetectable		 5l94A-1pytD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 VAL A  31
ILE A  74
ALA A  75
HIS A  50
VAL A 107
 None
 1.39A 5l94A-1q6wA:
undetectable		 5l94A-1q6wA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		5 VAL A 127
ILE A  45
ALA A 502
PHE A 123
VAL A 125
 None
 1.07A 5l94A-1r4nA:
undetectable		 5l94A-1r4nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		5 VAL A 269
ILE A 202
ALA A 190
VAL A 154
PHE A 168
 None
 1.34A 5l94A-1r5jA:
undetectable		 5l94A-1r5jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		5 VAL A  30
ALA A 353
VAL A  11
HIS A  39
VAL A  12
 None
 1.50A 5l94A-1s6rA:
undetectable		 5l94A-1s6rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ILE C  63
ALA C  67
VAL C  41
PHE C  40
VAL C  37
 None
 1.41A 5l94A-1sxjC:
undetectable		 5l94A-1sxjC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		5 VAL A 217
ILE A 212
ALA A 185
THR A 152
VAL A 229
 None
 1.47A 5l94A-1t5oA:
undetectable		 5l94A-1t5oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		5 VAL A 220
ILE A 212
ALA A 185
VAL A 149
VAL A 226
 None
 0.97A 5l94A-1t5oA:
undetectable		 5l94A-1t5oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		5 VAL A 103
ILE A  99
ALA A  23
VAL A  17
VAL A  64
 None
 1.28A 5l94A-1taqA:
undetectable		 5l94A-1taqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 VAL A 209
ILE A 200
ALA A 170
PHE A 184
VAL A 185
 None
 1.12A 5l94A-1tdjA:
undetectable		 5l94A-1tdjA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 VAL A  13
ILE A 176
ALA A 173
VAL A 144
VAL A 145
 None
 1.44A 5l94A-1tf1A:
undetectable		 5l94A-1tf1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 VAL A 696
ILE A 690
ALA A 685
VAL A 720
VAL A 678
 None
 1.37A 5l94A-1tmoA:
undetectable		 5l94A-1tmoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		5 VAL A 386
ILE A 346
ALA A 350
VAL A  83
VAL A  81
 None
 1.20A 5l94A-1uuoA:
undetectable		 5l94A-1uuoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 VAL A 371
ALA A 417
VAL A 385
HIS A 405
VAL A 319
 None
 1.33A 5l94A-1uwiA:
undetectable		 5l94A-1uwiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyw FAB ANTIBODY HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 121
ALA H 118
THR H 204
VAL H 150
VAL H 197
 None
 1.47A 5l94A-1uywH:
undetectable		 5l94A-1uywH:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 VAL A  58
ILE A  30
ALA A   9
THR A  49
VAL A  65
 None
 1.43A 5l94A-1vh1A:
undetectable		 5l94A-1vh1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 VAL A 112
ILE A 108
ALA A 106
VAL A   5
VAL A  95
 None
 1.50A 5l94A-1vh1A:
undetectable		 5l94A-1vh1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi6 30S RIBOSOMAL
PROTEIN S2P

(Archaeoglobus
fulgidus) 		PF00318
(Ribosomal_S2) 		5 VAL A 140
ILE A 138
VAL A  73
PHE A 119
VAL A 120
 NA  A 208 (-4.3A)
None
None
None
None
 1.36A 5l94A-1vi6A:
undetectable		 5l94A-1vi6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF01515
(PTA_PTB) 		5 VAL A 266
ILE A 181
ALA A 179
VAL A 234
VAL A 199
 None
 1.40A 5l94A-1vmiA:
undetectable		 5l94A-1vmiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		5 VAL A  85
ALA A  48
THR A  47
VAL A  25
HIS A  32
 None
 1.27A 5l94A-1vzyA:
undetectable		 5l94A-1vzyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 VAL A 115
ILE A 149
ALA A 150
VAL A 164
VAL A 215
 None
 1.09A 5l94A-1wpwA:
undetectable		 5l94A-1wpwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		5 VAL A 395
ILE A 250
ALA A 378
PHE A  96
VAL A  95
 None
 1.35A 5l94A-1x1qA:
undetectable		 5l94A-1x1qA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A  67
ALA A  75
VAL A 104
HIS A  90
VAL A  85
 None
 1.07A 5l94A-1xfcA:
undetectable		 5l94A-1xfcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF02581
(TMP-TENI) 		5 VAL A 171
ILE A 163
ALA A 180
VAL A 157
VAL A 176
 None
 1.21A 5l94A-1xi3A:
undetectable		 5l94A-1xi3A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7p HYPOTHETICAL PROTEIN
AF1403

(Archaeoglobus
fulgidus) 		PF01842
(ACT) 		5 VAL A 146
ILE A 173
ALA A 195
VAL A 120
VAL A  88
 None
 1.41A 5l94A-1y7pA:
undetectable		 5l94A-1y7pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A  15
ILE A 120
ALA A 119
VAL A   8
VAL A  11
 None
 1.16A 5l94A-1y8tA:
undetectable		 5l94A-1y8tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		5 VAL A 131
ILE A 100
ALA A  42
VAL A  49
VAL A  51
 None
 1.45A 5l94A-1ybdA:
undetectable		 5l94A-1ybdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 VAL A  78
ILE A 687
ALA A 655
THR A 657
VAL A  68
 None
 1.27A 5l94A-1yr2A:
undetectable		 5l94A-1yr2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 ILE A 267
ALA A  77
THR A 163
HIS A   7
VAL A 205
 None
 1.38A 5l94A-1zswA:
undetectable		 5l94A-1zswA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		4 ILE A  72
ALA A  73
VAL A 140
VAL A  84
 None
 0.51A 5l94A-1zwxA:
undetectable		 5l94A-1zwxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		5 ILE A 116
ALA A 115
VAL A  48
PHE A  45
VAL A   3
 None
 1.42A 5l94A-1zy2A:
undetectable		 5l94A-1zy2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 VAL A 105
ILE A  59
ALA A  28
VAL A 283
HIS A  38
 None
 1.37A 5l94A-2b2nA:
undetectable		 5l94A-2b2nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 VAL A  59
ILE A  88
VAL A 120
VAL A 105
 None
 0.49A 5l94A-2b39A:
undetectable		 5l94A-2b39A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		5 VAL A 225
ILE A 191
ALA A 219
HIS A 250
PHE A 223
 None
 1.44A 5l94A-2cb0A:
undetectable		 5l94A-2cb0A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		5 VAL A  15
ALA A   9
VAL A  41
HIS A 120
VAL A  27
 None
 1.28A 5l94A-2cdpA:
undetectable		 5l94A-2cdpA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		5 VAL A 562
ILE A 578
ALA A 577
VAL A 566
VAL A 565
 None
 1.10A 5l94A-2cgeA:
undetectable		 5l94A-2cgeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		5 VAL A 201
ILE A 242
ALA A 245
VAL A 260
VAL A 199
 None
 1.39A 5l94A-2cygA:
undetectable		 5l94A-2cygA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A  50
ALA A 305
VAL A  25
PHE A   6
VAL A   5
 None
 1.44A 5l94A-2dbrA:
undetectable		 5l94A-2dbrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		5 VAL A 414
ILE A 380
ALA A 381
VAL A 489
VAL A 529
 None
 1.23A 5l94A-2du3A:
undetectable		 5l94A-2du3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		5 ILE A 137
ALA A 138
VAL A 231
HIS A 235
VAL A 177
 None
 1.14A 5l94A-2e0nA:
undetectable		 5l94A-2e0nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		5 VAL A 225
ILE A 191
ALA A 219
HIS A 250
PHE A 223
 None
 1.45A 5l94A-2e5fA:
undetectable		 5l94A-2e5fA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 268
ILE A 182
THR A 203
VAL A 263
VAL A 265
 None
 1.47A 5l94A-2eq9A:
undetectable		 5l94A-2eq9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 VAL A 389
ILE A 386
ALA A 437
VAL A 325
VAL A 324
 None
 1.45A 5l94A-2et6A:
undetectable		 5l94A-2et6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 234
ALA A 235
VAL A 171
HIS A 143
VAL A 170
 None
 1.18A 5l94A-2eu9A:
undetectable		 5l94A-2eu9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 VAL X 172
ILE X 218
ALA X 219
VAL X  77
VAL X 127
 None
 0.87A 5l94A-2fwmX:
undetectable		 5l94A-2fwmX:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h31 MULTIFUNCTIONAL
PROTEIN ADE2

(Homo sapiens) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		5 VAL A 268
ILE A 293
ALA A 388
PHE A 325
VAL A 326
 None
 1.29A 5l94A-2h31A:
undetectable		 5l94A-2h31A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 VAL A 714
ILE A 694
ALA A 691
THR A 687
VAL A 712
 None
 1.48A 5l94A-2hg4A:
undetectable		 5l94A-2hg4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhg HYPOTHETICAL PROTEIN
RPA3614

(Rhodopseudomonas
palustris) 		PF00581
(Rhodanese) 		5 VAL A  42
ALA A 114
VAL A  39
HIS A  32
VAL A  40
 None
 1.32A 5l94A-2hhgA:
undetectable		 5l94A-2hhgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 ILE A 291
ALA A 323
VAL A 260
PHE A 178
VAL A 261
 None
 1.39A 5l94A-2hjgA:
undetectable		 5l94A-2hjgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 VAL A 263
ILE A 291
ALA A 323
VAL A 260
VAL A 261
 None
 1.24A 5l94A-2hjgA:
undetectable		 5l94A-2hjgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 ILE A  13
ALA A  12
VAL A 130
PHE A 132
VAL A 131
 None
 1.17A 5l94A-2hrzA:
undetectable		 5l94A-2hrzA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE

(Streptomyces
exfoliatus) 		PF13561
(adh_short_C2) 		5 VAL A 180
ILE A 217
ALA A 218
VAL A  85
VAL A 135
 None
 0.91A 5l94A-2hsdA:
undetectable		 5l94A-2hsdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 VAL G 296
ILE G 261
ALA G 259
VAL G 254
VAL G 303
 None
 1.14A 5l94A-2iouG:
undetectable		 5l94A-2iouG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 VAL A 109
ILE A 205
ALA A 202
PHE A 169
VAL A 170
 None
 1.18A 5l94A-2iueA:
undetectable		 5l94A-2iueA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 VAL A  85
ILE A  23
ALA A 365
THR A 369
VAL A   3
 None
 1.49A 5l94A-2iw1A:
undetectable		 5l94A-2iw1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 VAL A  95
ILE A 367
ALA A 365
THR A 369
VAL A   3
 None
 1.50A 5l94A-2iw1A:
undetectable		 5l94A-2iw1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		5 VAL A  36
ILE A  47
ALA A  49
VAL A  58
VAL A  28
 None
 1.44A 5l94A-2ixbA:
undetectable		 5l94A-2ixbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyk REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF09416
(UPF1_Zn_bind) 		5 VAL A  81
ILE A 123
VAL A  25
HIS A  49
VAL A  58
 None
None
None
ZN  A1164 (-3.3A)
None
 1.38A 5l94A-2iykA:
undetectable		 5l94A-2iykA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 358
ILE A 362
VAL A 273
HIS A 396
PHE A 270
 None
 1.41A 5l94A-2jbrA:
undetectable		 5l94A-2jbrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 185
ILE A 183
VAL A 158
PHE A 157
VAL A 114
 None
 1.32A 5l94A-2kxhA:
undetectable		 5l94A-2kxhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l32 SMALL ARCHAEAL
MODIFIER PROTEIN 2

(Haloferax
volcanii) 		no annotation 5 VAL A   3
ALA A  24
THR A  22
VAL A  52
VAL A  54
 None
 1.38A 5l94A-2l32A:
undetectable		 5l94A-2l32A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcw RNA-BINDING PROTEIN
FUS

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 339
ILE A 311
VAL A 366
PHE A 288
VAL A 289
 None
 1.46A 5l94A-2lcwA:
undetectable		 5l94A-2lcwA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5r ACYL CARRIER PROTEIN

(Leishmania
major) 		PF00550
(PP-binding) 		5 ILE A  73
ALA A  69
VAL A  40
PHE A  45
VAL A  43
 None
 1.23A 5l94A-2m5rA:
undetectable		 5l94A-2m5rA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1

(Mesorhizobium
loti) 		PF00885
(DMRL_synthase) 		5 VAL A  52
THR A  77
VAL A  16
PHE A  50
VAL A  17
 None
 1.39A 5l94A-2obxA:
undetectable		 5l94A-2obxA:
18.77