SIMILAR PATTERNS OF AMINO ACIDS FOR 5L8O_B_CHDB1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 ILE A 138
PHE A 216
LEU A  54
VAL A  61
SER A  38
 None
 1.25A 5l8oB-1dt2A:
0.0		 5l8oB-1dt2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivz HYPOTHETICAL PROTEIN
1110008I14RIK

(Mus musculus) 		PF01390
(SEA) 		5 THR A 107
PHE A 103
LEU A  23
VAL A  81
SER A 122
 None
 1.19A 5l8oB-1ivzA:
0.0		 5l8oB-1ivzA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 GLN A  51
ILE A  71
PHE A  94
VAL A  83
SER A 101
 None
 1.23A 5l8oB-1o1uA:
17.5		 5l8oB-1o1uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 GLN A  51
ILE A  71
VAL A  83
SER A 101
GLU A 110
 None
 1.38A 5l8oB-1o1uA:
17.5		 5l8oB-1o1uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
ILE A  71
THR A  73
GLU A 110
 None
 1.10A 5l8oB-1o1uA:
17.5		 5l8oB-1o1uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		8 TYR A  14
TRP A  49
GLN A  51
ILE A  71
LEU A  90
SER A 101
GLU A 110
SER A 112
 None
 0.87A 5l8oB-1o1uA:
17.5		 5l8oB-1o1uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		8 TYR A  14
TRP A  49
GLN A  51
ILE A  71
LEU A  90
VAL A  92
SER A 101
SER A 112
 None
 0.95A 5l8oB-1o1uA:
17.5		 5l8oB-1o1uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 GLN A 161
THR A 163
LEU A  91
SER A  92
SER A  66
 None
 1.45A 5l8oB-1v71A:
0.0		 5l8oB-1v71A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 TYR C 256
LEU C 276
GLN C 285
SER C 280
GLU C 281
 None
 1.47A 5l8oB-1w36C:
undetectable		 5l8oB-1w36C:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4g HYPOTHETICAL PROTEIN
BSU11850

(Bacillus
subtilis) 		PF13563
(2_5_RNA_ligase2) 		5 GLN A 120
ILE A  31
LEU A  35
VAL A   6
SER A  40
 None
 1.33A 5l8oB-2d4gA:
0.0		 5l8oB-2d4gA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 ILE A 117
THR A 100
PHE A 164
LEU A 177
GLU A 183
 None
 1.42A 5l8oB-2deoA:
undetectable		 5l8oB-2deoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxa PROTEIN YBAK

(Escherichia
coli) 		PF04073
(tRNA_edit) 		5 ILE A  17
THR A  19
LEU A 106
VAL A   5
SER A 104
 None
 1.34A 5l8oB-2dxaA:
undetectable		 5l8oB-2dxaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 105
THR A 104
LEU A  94
VAL A   9
SER A  20
 None
None
G1L  A 400 (-4.3A)
None
G1L  A 400 (-4.2A)
 1.45A 5l8oB-2i80A:
0.0		 5l8oB-2i80A:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 TYR A  14
TRP A  49
GLN A  51
GLU A 110
SER A 112
 CHO  A 200 ( 3.8A)
CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 (-3.7A)
CHO  A 200 ( 4.5A)
 0.91A 5l8oB-2lbaA:
20.0		 5l8oB-2lbaA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 194
THR A 193
LEU A 174
VAL A 211
SER A 142
 None
 1.44A 5l8oB-2q09A:
undetectable		 5l8oB-2q09A:
13.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TYR A  14
ILE A  70
THR A  72
LEU A  89
GLU A 109
 None
IPA  A 141 ( 4.5A)
GOL  A 145 (-3.2A)
IPA  A 142 ( 4.7A)
None
 0.92A 5l8oB-2qo4A:
20.9		 5l8oB-2qo4A:
43.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 TYR A 112
ILE A 252
PHE A 123
LEU A 281
SER A 319
 None
 1.47A 5l8oB-2z67A:
undetectable		 5l8oB-2z67A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		5 TYR A  23
ILE A 272
PHE A 268
LEU A 193
GLN A 191
 None
None
SO4  A 297 (-4.8A)
None
None
 1.44A 5l8oB-3bjxA:
undetectable		 5l8oB-3bjxA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cei SUPEROXIDE DISMUTASE

(Helicobacter
pylori) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A 133
LEU A  87
VAL A 186
SER A  88
GLU A  90
 None
 1.38A 5l8oB-3ceiA:
undetectable		 5l8oB-3ceiA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
LEU A  90
GLU A 110
SER A 112
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 (-4.4A)
None
None
 0.57A 5l8oB-3elzA:
20.4		 5l8oB-3elzA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
THR A  73
LEU A  90
SER A 112
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 200 (-3.1A)
CHD  A 150 (-4.4A)
None
 0.82A 5l8oB-3elzA:
20.4		 5l8oB-3elzA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
THR A  73
PHE A  79
LEU A  90
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 200 (-3.1A)
CHD  A 153 ( 4.9A)
CHD  A 150 (-4.4A)
 0.91A 5l8oB-3elzA:
20.4		 5l8oB-3elzA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TRP A  49
LEU A  90
GLN A  99
GLU A 110
SER A 112
 CHD  A 150 (-3.5A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.3A)
None
None
 0.90A 5l8oB-3elzA:
20.4		 5l8oB-3elzA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 TRP A  49
THR A  73
LEU A  90
GLN A  99
SER A 112
 CHD  A 150 (-3.5A)
CHD  A 200 (-3.1A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.3A)
None
 0.98A 5l8oB-3elzA:
20.4		 5l8oB-3elzA:
55.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 TYR A 450
ILE A 844
LEU A 820
SER A 821
GLU A 822
 None
 1.30A 5l8oB-3fahA:
undetectable		 5l8oB-3fahA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 163
THR A 152
PHE A 247
LEU A 212
SER A 130
 None
 1.42A 5l8oB-3fcjA:
undetectable		 5l8oB-3fcjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 163
THR A 152
PHE A 247
LEU A 212
SER A 173
 None
 1.40A 5l8oB-3fcjA:
undetectable		 5l8oB-3fcjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 163
THR A 152
PHE A 247
VAL A 213
SER A 130
 None
 1.24A 5l8oB-3fcjA:
undetectable		 5l8oB-3fcjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 163
THR A 152
PHE A 247
VAL A 213
SER A 173
 None
 1.50A 5l8oB-3fcjA:
undetectable		 5l8oB-3fcjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		5 TYR B 379
TRP B 428
ILE B 385
THR B 326
VAL B 415
 NA  B 606 (-4.5A)
None
None
None
None
 1.39A 5l8oB-3fgtB:
0.6		 5l8oB-3fgtB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 ILE A 196
THR A 756
PHE A 100
GLN A 217
SER A 216
 None
 1.24A 5l8oB-3fqdA:
undetectable		 5l8oB-3fqdA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 TRP A  27
GLN A  30
ILE A  16
VAL A 160
SER A 200
 None
 1.37A 5l8oB-3gymA:
undetectable		 5l8oB-3gymA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE

(Bacillus cereus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A 346
PHE A  85
LEU A 279
GLN A 280
SER A 140
 None
None
PEG  A 385 ( 4.2A)
None
None
 1.36A 5l8oB-3ju7A:
undetectable		 5l8oB-3ju7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		5 ILE A  89
LEU A 129
VAL A 151
GLN A 130
SER A 131
 None
 0.92A 5l8oB-3jy6A:
undetectable		 5l8oB-3jy6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 ILE A 571
PHE A 556
VAL A 453
GLN A 479
SER A 592
 None
 1.28A 5l8oB-3qsqA:
0.8		 5l8oB-3qsqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shr CGMP-DEPENDENT
PROTEIN KINASE 1

(Bos taurus) 		PF00027
(cNMP_binding) 		5 TYR A 211
ILE A 247
PHE A 289
VAL A 265
SER A 261
 None
 1.49A 5l8oB-3shrA:
undetectable		 5l8oB-3shrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLN A 133
ILE A 301
THR A 132
PHE A  59
SER A  52
 None
None
None
None
SO4  A 340 (-3.0A)
 1.38A 5l8oB-3txxA:
undetectable		 5l8oB-3txxA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina) 		PF00248
(Aldo_ket_red) 		5 PHE A  50
LEU A 175
VAL A 202
GLN A 176
SER A 156
 None
 1.45A 5l8oB-3v0tA:
undetectable		 5l8oB-3v0tA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 ILE A 380
LEU A 334
VAL A 315
GLN A 333
SER A 370
 None
 1.50A 5l8oB-3vtrA:
undetectable		 5l8oB-3vtrA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6s 3-DEHYDROQUINATE
DEHYDRATASE

(Helicobacter
pylori) 		PF01220
(DHquinase_II) 		5 ILE A  33
THR A  36
LEU A  27
VAL A  25
GLN A  29
 None
 1.44A 5l8oB-4b6sA:
undetectable		 5l8oB-4b6sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		5 PHE A 413
LEU A 573
VAL A 243
SER A 546
GLU A 549
 None
 1.34A 5l8oB-4jeuA:
undetectable		 5l8oB-4jeuA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 5 ILE A 105
PHE A 101
LEU A  35
GLN A  36
GLU A 269
 None
 1.44A 5l8oB-4k3zA:
undetectable		 5l8oB-4k3zA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 ILE E 212
THR E 214
LEU E 263
VAL E 242
GLU E 259
 None
 1.05A 5l8oB-4obuE:
undetectable		 5l8oB-4obuE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 TYR A 137
LEU A 191
SER A 308
GLU A 309
SER A 313
 None
 1.35A 5l8oB-4pl0A:
undetectable		 5l8oB-4pl0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 TRP A 152
GLN A 155
ILE A 142
GLN A 231
SER A  59
 None
 1.32A 5l8oB-4w7gA:
undetectable		 5l8oB-4w7gA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1

(Mus musculus) 		no annotation 5 GLN A1615
THR A1616
LEU A1607
VAL A1640
GLU A1608
 None
 1.43A 5l8oB-4w8pA:
undetectable		 5l8oB-4w8pA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		5 GLN A 540
LEU A 315
GLN A 316
GLU A 317
SER A 509
 None
 1.42A 5l8oB-4y4rA:
1.0		 5l8oB-4y4rA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		5 GLN A 148
THR A 147
PHE A 104
LEU A  24
GLU A  26
 None
None
SAH  A 301 (-4.8A)
None
None
 1.49A 5l8oB-5c77A:
undetectable		 5l8oB-5c77A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd8 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		5 ILE A 177
PHE A 189
LEU A 200
VAL A 195
SER A 149
 None
 1.30A 5l8oB-5cd8A:
undetectable		 5l8oB-5cd8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		5 TRP A 175
ILE A 136
THR A 135
PHE A  92
VAL A  43
 None
None
NAG  A 704 ( 4.6A)
None
None
 1.14A 5l8oB-5ebbA:
undetectable		 5l8oB-5ebbA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		5 TYR A 331
ILE A 582
THR A 549
PHE A 551
LEU A 481
 None
 1.25A 5l8oB-5hsiA:
undetectable		 5l8oB-5hsiA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 ILE A 310
LEU A 330
VAL A 325
GLN A 329
GLU A 332
 None
 1.30A 5l8oB-5inwA:
undetectable		 5l8oB-5inwA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 5 TYR A 103
ILE A 214
THR A 217
GLN A  63
SER A 123
 None
 1.43A 5l8oB-5o6kA:
undetectable		 5l8oB-5o6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PRE-MRNA-PROCESSING
FACTOR 39

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 TYR D 448
ILE E 438
THR E 473
PHE E 455
LEU E 445
 None
 1.36A 5l8oB-5uz5D:
undetectable		 5l8oB-5uz5D:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
BETA-2-MICROGLOBULIN

(Felis catus;
Felis catus) 		no annotation
no annotation 		5 TYR B  63
ILE A 214
PHE A 209
LEU A 231
GLU A 233
 None
 1.15A 5l8oB-5xmmB:
undetectable		 5l8oB-5xmmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P
KLLA0F20922P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		no annotation
no annotation 		5 GLN B 219
ILE A 183
LEU A 267
SER A 234
GLU A 523
 None
 1.17A 5l8oB-5y5aB:
undetectable		 5l8oB-5y5aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 5 TYR A  55
ILE A  65
LEU A 167
VAL A 181
SER A 190
 None
 1.37A 5l8oB-5y9pA:
1.0		 5l8oB-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 5 ILE F 291
PHE F 287
LEU F 142
GLN F 131
SER F 139
 None
 0.94A 5l8oB-6btmF:
undetectable		 5l8oB-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr


(;
) 		no annotation
no annotation 		5 TYR B 138
PHE B 318
VAL B  15
GLN B  16
GLU A 688
 None
 1.42A 5l8oB-6dbrB:
undetectable		 5l8oB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 ILE A 395
THR A 394
LEU A 251
VAL A 249
SER A 254
 None
None
HEM  A 501 (-3.5A)
None
None
 1.14A 5l8oB-6gk6A:
undetectable		 5l8oB-6gk6A:
undetectable