SIMILAR PATTERNS OF AMINO ACIDS FOR 5L7I_B_VISB1202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 TRP A 272
ASP A 343
ARG A 347
GLU A 233
LEU A 236
 None
SO4  A 503 (-4.7A)
None
None
None
 1.45A 5l7iB-2b1pA:
2.0		 5l7iB-2b1pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 ASP A 307
SER A 310
ARG A 411
GLU A 487
LEU A 468
 None
 1.36A 5l7iB-2fvmA:
0.1		 5l7iB-2fvmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		5 ASP A 320
ARG A 194
ASP A 190
ASN A 147
LEU A 301
 None
None
None
ACT  A   1 (-3.2A)
None
 1.38A 5l7iB-3kkeA:
0.0		 5l7iB-3kkeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		5 TRP A 341
TYR A 316
ASP A 203
PRO A 138
LEU A 240
 None
EDO  A 417 (-4.6A)
EDO  A 417 ( 4.7A)
None
None
 1.48A 5l7iB-3mveA:
0.7		 5l7iB-3mveA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n4w CYTOCHROME
B(562),SMOOTHENED
HOMOLOG

(Homo sapiens;
Shigella
flexneri) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		11 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
SNT  A 605 ( 4.7A)
SNT  A 605 (-4.6A)
None
None
None
None
None
SNT  A 605 (-4.0A)
SNT  A 605 (-3.6A)
SNT  A 605 ( 4.4A)
 0.60A 5l7iB-4n4wA:
37.8		 5l7iB-4n4wA:
61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n4w CYTOCHROME
B(562),SMOOTHENED
HOMOLOG

(Homo sapiens;
Shigella
flexneri) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		8 TRP A 281
ASP A 384
SER A 387
TYR A 394
ASP A 473
PRO A 513
LEU A 522
MET A 525
 None
SNT  A 605 ( 4.7A)
SNT  A 605 (-4.6A)
None
None
None
SNT  A 605 ( 4.4A)
SNT  A 605 (-4.6A)
 0.68A 5l7iB-4n4wA:
37.8		 5l7iB-4n4wA:
61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
CY8  A1201 (-3.2A)
None
None
None
 1.13A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		11 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
CY8  A1201 (-3.2A)
None
CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-4.2A)
CY8  A1201 (-3.7A)
CY8  A1201 ( 4.9A)
CY8  A1201 (-3.3A)
None
None
 0.79A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		11 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
 0.53A 5l7iB-5l7dA:
40.3		 5l7iB-5l7dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		8 TRP A 281
ASP A 384
SER A 387
TYR A 394
ASP A 473
PRO A 513
LEU A 522
MET A 525
 None
 0.68A 5l7iB-5l7dA:
40.3		 5l7iB-5l7dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 ASP A 410
PRO A 444
ASN A 936
LEU A 932
MET A1006
 None
 1.21A 5l7iB-5lq3A:
0.2		 5l7iB-5lq3A:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		5 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
None
 1.10A 5l7iB-5v57A:
39.4		 5l7iB-5v57A:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		11 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
836  A1201 (-3.0A)
836  A1201 ( 4.9A)
836  A1201 (-3.6A)
836  A1201 (-4.1A)
836  A1201 (-3.5A)
836  A1201 (-3.4A)
836  A1201 (-4.6A)
 0.54A 5l7iB-5v57A:
39.4		 5l7iB-5v57A:
79.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 ASP A 357
SER A 360
TYR A 367
GLN A 450
MET A 298
 None
 1.43A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 9 TRP A 254
ASP A 357
SER A 360
TYR A 367
ARG A 373
ASP A 446
PRO A 486
GLU A 491
ASN A 494
 None
 0.98A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 10 TRP A 254
ASP A 357
SER A 360
TYR A 367
ASP A 446
GLN A 450
PRO A 486
GLU A 491
ASN A 494
MET A 498
 None
 0.91A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 9 TRP A 254
SER A 360
TYR A 367
ARG A 373
ASP A 446
PRO A 486
GLU A 491
ASN A 494
LEU A 495
 None
 0.89A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 10 TRP A 254
SER A 360
TYR A 367
ASP A 446
GLN A 450
PRO A 486
GLU A 491
ASN A 494
LEU A 495
MET A 498
 None
 0.77A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29