SIMILAR PATTERNS OF AMINO ACIDS FOR 5L6E_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 ASP A 195
ASN A  31
ASN A 192
GLN A  62
 None
 1.18A 5l6eA-1a8sA:
1.4		 5l6eA-1a8sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		4 ASP A  21
ASP A 154
ARG A 126
ASN A 164
 None
 1.14A 5l6eA-1b24A:
undetectable		 5l6eA-1b24A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		4 ASP A 354
ASP A 180
ASN A 230
ASN A 310
 None
 1.27A 5l6eA-1bvwA:
undetectable		 5l6eA-1bvwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ASP A 157
ASP A 147
ARG A 137
GLN A 134
 None
 1.14A 5l6eA-1c4kA:
undetectable		 5l6eA-1c4kA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 ASP A 450
ASP A 455
ASN A 451
GLN A  33
 None
 1.16A 5l6eA-1cbgA:
undetectable		 5l6eA-1cbgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 ASP A 155
ARG A 132
ASN A   5
GLN A 183
 None
 1.15A 5l6eA-1dr6A:
undetectable		 5l6eA-1dr6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 ASP M 461
ASN M 466
ASN M 462
GLN M  39
 None
None
None
GOL  M 936 (-3.1A)
 1.01A 5l6eA-1dwaM:
undetectable		 5l6eA-1dwaM:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 ASP A 378
ASP A 506
ARG A 373
GLN A 495
 None
 1.28A 5l6eA-1f0iA:
0.4		 5l6eA-1f0iA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B

(Bacillus
subtilis) 		PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		4 ASP A  31
ASN A  42
ASN A  34
GLN A  37
 None
None
MG  E2001 ( 4.6A)
None
 1.26A 5l6eA-1f51A:
undetectable		 5l6eA-1f51A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 ASP A 125
ASN A 303
ASN A 300
GLN A 298
 None
 1.25A 5l6eA-1fhfA:
undetectable		 5l6eA-1fhfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 ASP A 412
ASP A 170
ASN A 163
GLN A 417
 None
 1.24A 5l6eA-1io1A:
undetectable		 5l6eA-1io1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 ASP A1203
ASP A1119
ASN A1141
ASN A1182
 None
None
None
CA  A2003 (-3.6A)
 1.25A 5l6eA-1jl5A:
undetectable		 5l6eA-1jl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 ASP A  69
ASP A  25
ASN A  23
GLN A  60
 None
 1.03A 5l6eA-1m9iA:
undetectable		 5l6eA-1m9iA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		4 ASP A 131
ASP A 106
ARG A  15
ASN A  19
 None
 1.13A 5l6eA-1n1qA:
undetectable		 5l6eA-1n1qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdk MANNOSE-BINDING
PROTEIN-C

(Rattus rattus) 		PF00059
(Lectin_C) 		4 ASP 1 211
ASN 1 127
ASN 1 199
GLN 1 167
 CA  1   2 (-3.1A)
None
CA  1 227 (-3.4A)
None
 1.27A 5l6eA-1rdk1:
undetectable		 5l6eA-1rdk1:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 ASP A  95
ASP A  63
ARG A 178
ASN A 174
 None
 1.14A 5l6eA-1t6pA:
undetectable		 5l6eA-1t6pA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 ASP A 577
ASP A 721
ARG A 491
GLN A 497
 None
 1.15A 5l6eA-1u2lA:
undetectable		 5l6eA-1u2lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ASP A 169
ASP A 180
ASN A 176
ASN A 168
 None
 1.26A 5l6eA-1udqA:
undetectable		 5l6eA-1udqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9z DNA MISMATCH REPAIR
PROTEIN MUTL

(Escherichia
coli) 		PF08676
(MutL_C) 		4 ARG A 563
ASN A 564
ASN A 556
GLN A 559
 None
 1.24A 5l6eA-1x9zA:
undetectable		 5l6eA-1x9zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ASP A 144
ASP A 203
ARG A 200
ASN A 186
 FE  A 313 (-2.6A)
None
None
None
 1.30A 5l6eA-1xvxA:
undetectable		 5l6eA-1xvxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13420
(Acetyltransf_4) 		4 ASP A  13
ASP A  39
ARG A  43
ASN A  23
 None
None
SO4  A1002 (-3.7A)
None
 1.13A 5l6eA-1yr0A:
undetectable		 5l6eA-1yr0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASP A 391
ASP A  18
ASN A  22
GLN A  27
 None
 1.09A 5l6eA-1z01A:
undetectable		 5l6eA-1z01A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASP A 281
ASP A 238
ASN A 271
GLN A 352
 None
 1.24A 5l6eA-1zuoA:
undetectable		 5l6eA-1zuoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		4 ASP X 297
ASP X  38
ARG X 255
GLN X 311
 None
 0.95A 5l6eA-2ae0X:
undetectable		 5l6eA-2ae0X:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		4 ASP A 540
ASN A 557
ASN A 545
GLN A 585
 None
 1.12A 5l6eA-2ckhA:
undetectable		 5l6eA-2ckhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djq SH3 DOMAIN
CONTAINING RING
FINGER 2

(Mus musculus) 		PF07653
(SH3_2) 		4 ASP A  23
ASP A  39
ARG A  36
GLN A  44
 None
 0.85A 5l6eA-2djqA:
undetectable		 5l6eA-2djqA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f17 THIAMIN
PYROPHOSPHOKINASE 1

(Mus musculus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 ASP A  46
ASP A 133
ASN A  25
GLN A  26
 MG  A 901 ( 3.4A)
None
AMP  A 301 (-3.3A)
AMP  A 301 (-3.7A)
 1.17A 5l6eA-2f17A:
2.3		 5l6eA-2f17A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 316
ARG A  84
ASN A 337
GLN A 295
 None
 1.22A 5l6eA-2gskA:
undetectable		 5l6eA-2gskA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 ASP A 314
ASP A 307
ARG A 311
ASN A 313
 None
 1.22A 5l6eA-2hihA:
undetectable		 5l6eA-2hihA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 ASP A 112
ASP A 136
ASN A 159
GLN A  77
 None
None
AI2  A 501 (-3.3A)
AI2  A 501 (-2.8A)
 1.21A 5l6eA-2hj9A:
undetectable		 5l6eA-2hj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		4 ASP A  79
ASN A  58
ASN A  75
GLN A  53
 None
 1.24A 5l6eA-2i79A:
undetectable		 5l6eA-2i79A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9d HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059

(Methanocaldococcus
jannaschii) 		PF00543
(P-II) 		4 ASP E  69
ASP E  22
ASN E  80
ASN E  72
 None
 1.16A 5l6eA-2j9dE:
undetectable		 5l6eA-2j9dE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 ASP A 469
ASN A 474
ASN A 470
GLN A  57
 None
 1.18A 5l6eA-2jf7A:
undetectable		 5l6eA-2jf7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 ASP X 421
ASN X 426
ASN X 422
GLN X  17
 None
 1.12A 5l6eA-2jfeX:
undetectable		 5l6eA-2jfeX:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kw3 DNA-BINDING PROTEIN
RFX5
REGULATORY FACTOR
X-ASSOCIATED PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
PF15289
(RFXA_RFXANK_bdg) 		5 ASP A  60
ASP C 219
ARG C 235
ASN C 232
ASN A  59
 None
 1.35A 5l6eA-2kw3A:
undetectable		 5l6eA-2kw3A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8x LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		4 ASP A 147
ASP A  77
ASN A 101
GLN A 118
 None
 1.16A 5l6eA-2n8xA:
undetectable		 5l6eA-2n8xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ASP A 116
ASP A 141
ARG A 208
ASN A 184
 None
 1.27A 5l6eA-2o4vA:
undetectable		 5l6eA-2o4vA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 ASP A 239
ASP A 220
ARG A 245
ASN A 267
 None
 1.21A 5l6eA-2o5pA:
undetectable		 5l6eA-2o5pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 ASP A 193
ASP A  66
ARG A  64
ASN A  42
 None
 1.16A 5l6eA-2p4bA:
undetectable		 5l6eA-2p4bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 ASP A  28
ASN A 103
ASN A  32
GLN A  36
 None
 1.26A 5l6eA-2pbfA:
2.0		 5l6eA-2pbfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 ASP A 209
ARG A 159
ASN A 173
GLN A 163
 None
 1.06A 5l6eA-2qtyA:
undetectable		 5l6eA-2qtyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 391
ARG A 389
ASN A 409
GLN A 429
 None
 1.23A 5l6eA-2uxtA:
undetectable		 5l6eA-2uxtA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Schizosaccharomyces
pombe) 		PF13519
(VWA_2) 		4 ASP A  43
ARG A 101
ASN A  47
GLN A 106
 None
 1.30A 5l6eA-2x5nA:
2.3		 5l6eA-2x5nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ASP A 276
ARG A 203
ASN A 201
GLN A 282
 None
 1.25A 5l6eA-3ai7A:
undetectable		 5l6eA-3ai7A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ARG A 158
ASN A 147
ASN A 116
GLN A 118
 None
CA  A1200 (-3.1A)
None
None
 1.18A 5l6eA-3ak5A:
undetectable		 5l6eA-3ak5A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASP A  23
ARG A  29
ASN A  30
GLN A 378
 None
 1.15A 5l6eA-3gkqA:
undetectable		 5l6eA-3gkqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ARG A 169
ASN A 141
ASN A  91
GLN A  93
 None
 1.15A 5l6eA-3h09A:
undetectable		 5l6eA-3h09A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASP A  63
ARG A  70
ASN A  60
GLN A  59
 None
 1.29A 5l6eA-3i12A:
undetectable		 5l6eA-3i12A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 305
ASP A 258
ARG A 300
GLN A 281
 None
 1.24A 5l6eA-3i3wA:
undetectable		 5l6eA-3i3wA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		4 ASP B  76
ARG B  41
ASN B  42
ASN B  74
 None
 1.04A 5l6eA-3j7aB:
undetectable		 5l6eA-3j7aB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 ASP A 107
ASN A 330
ASN A 487
GLN A 490
 None
 1.20A 5l6eA-3lfvA:
undetectable		 5l6eA-3lfvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ASP A 211
ARG A  77
ASN A  79
ASN A 187
 None
 1.18A 5l6eA-3o9pA:
undetectable		 5l6eA-3o9pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 ASP A 143
ARG A 159
ASN A 139
GLN A 135
 None
 1.19A 5l6eA-3odmA:
undetectable		 5l6eA-3odmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		4 ASP A 379
ASN A 390
ASN A 382
GLN A 472
 None
 0.97A 5l6eA-3unvA:
undetectable		 5l6eA-3unvA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ASP A  69
ARG A  68
ASN A 486
GLN A 559
 None
 1.27A 5l6eA-3zuqA:
undetectable		 5l6eA-3zuqA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ASP A 716
ARG A 712
ASN A 695
GLN A 709
 None
 1.29A 5l6eA-4bsnA:
undetectable		 5l6eA-4bsnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ASP A 713
ARG A 709
ASN A 692
GLN A 706
 None
 1.23A 5l6eA-4fgvA:
undetectable		 5l6eA-4fgvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goq HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF07372
(DUF1491) 		4 ASP A  74
ASP A  42
ARG A  49
GLN A  65
 None
 1.28A 5l6eA-4goqA:
undetectable		 5l6eA-4goqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 ASP A 312
ASP A 317
ARG A 292
GLN A 272
 None
 1.30A 5l6eA-4hnnA:
1.9		 5l6eA-4hnnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF16024
(DUF4785) 		4 ASP A 371
ASP A  45
ARG A 336
GLN A 338
 None
 1.24A 5l6eA-4kh9A:
undetectable		 5l6eA-4kh9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ASP A 120
ASP A 197
ASN A 122
GLN A 159
 25L  A1000 ( 4.4A)
None
25L  A1000 (-3.3A)
None
 1.06A 5l6eA-4o1oA:
undetectable		 5l6eA-4o1oA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 ASP B 161
ASP B 213
ARG B 123
ASN B 162
 None
 1.26A 5l6eA-4pswB:
undetectable		 5l6eA-4pswB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 ASP A  29
ASP A  65
ASN A  63
ASN A 336
 None
 0.99A 5l6eA-4r7fA:
undetectable		 5l6eA-4r7fA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 ASP A 116
ASP A 141
ARG A 209
ASN A 185
GLN A 183
 None
 1.47A 5l6eA-4rjwA:
undetectable		 5l6eA-4rjwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 ASP B 162
ARG B 140
ASN B 137
ASN B 163
 None
 1.06A 5l6eA-4rs1B:
undetectable		 5l6eA-4rs1B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGS

(Sphingomonas
sp.) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		4 ASP C  95
ASP C 134
ARG C 140
ASN C  96
 None
 1.22A 5l6eA-4tqvC:
undetectable		 5l6eA-4tqvC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		4 ASP A  62
ASP A 270
ARG A 273
GLN A  50
 None
MG  A 301 (-3.1A)
None
None
 1.28A 5l6eA-4xxpA:
undetectable		 5l6eA-4xxpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y66 MND1
PUTATIVE TBPIP
FAMILY PROTEIN

(Giardia
intestinalis;
Giardia
intestinalis) 		PF03962
(Mnd1)
PF07106
(TBPIP) 		4 ASP B 163
ARG A 154
ASN A 155
ASN B 160
 None
 1.15A 5l6eA-4y66B:
undetectable		 5l6eA-4y66B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 ASP A 149
ASP A 118
ARG A 174
GLN A 171
 None
 1.24A 5l6eA-4zr1A:
undetectable		 5l6eA-4zr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ASP A 648
ASP A 400
ARG A 432
GLN A 395
 None
None
None
ADP  A1103 (-3.4A)
 1.17A 5l6eA-5b7iA:
undetectable		 5l6eA-5b7iA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 ASP A 110
ARG A 170
ASN A 237
ASN A 171
 None
 1.13A 5l6eA-5fkrA:
undetectable		 5l6eA-5fkrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g26 INTIMIN

(Escherichia
coli) 		PF11924
(IAT_beta) 		4 ASP A 229
ASP A 390
ASN A 378
GLN A 439
 None
 1.27A 5l6eA-5g26A:
undetectable		 5l6eA-5g26A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ASP A 589
ASN A 484
ASN A 473
GLN A 477
 None
 1.12A 5l6eA-5h53A:
undetectable		 5l6eA-5h53A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 ASP A 263
ASP A 160
ARG A 181
ASN A 185
 None
None
MPD  A 504 ( 4.9A)
MPD  A 504 (-3.4A)
 1.01A 5l6eA-5hucA:
undetectable		 5l6eA-5hucA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP A 377
ASP A 395
ARG A 536
ASN A 539
ASN A 549
GLN A 550
 None
 0.73A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ASP A 625
ASP A 607
ASN A 635
GLN A 530
 None
 1.17A 5l6eA-5iv8A:
undetectable		 5l6eA-5iv8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		4 ASP A 602
ASP A 584
ASN A 612
GLN A 507
 None
 1.21A 5l6eA-5iv9A:
undetectable		 5l6eA-5iv9A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TRANSCRIPTION
ELONGATION FACTOR A
PROTEIN 1

(Homo sapiens) 		PF01096
(TFIIS_C)
PF07500
(TFIIS_M) 		4 ASP U 200
ARG U 190
ASN U 189
ASN U 197
 None
 0.97A 5l6eA-5iy6U:
undetectable		 5l6eA-5iy6U:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		4 ASP A 532
ASP A 597
ASN A 620
ASN A 533
 None
 1.27A 5l6eA-5j8jA:
undetectable		 5l6eA-5j8jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 ASP A 344
ARG A 581
ASN A  69
GLN A 351
 None
None
EDO  A1012 (-3.3A)
None
 1.14A 5l6eA-5jjrA:
undetectable		 5l6eA-5jjrA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ASP A 297
ARG A 337
ASN A 333
ASN A 296
 None
 1.01A 5l6eA-5jwfA:
undetectable		 5l6eA-5jwfA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 ASP C 175
ASP C 187
ARG C 217
ASN C 221
 None
 0.89A 5l6eA-5ks8C:
undetectable		 5l6eA-5ks8C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 ARG A  99
ASN A 169
ASN A 225
GLN A 227
 None
 1.12A 5l6eA-5ly8A:
undetectable		 5l6eA-5ly8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 ASP A  73
ASP A  45
ASN A  15
ASN A 283
 None
None
None
CL  A 402 (-4.2A)
 1.17A 5l6eA-5m28A:
undetectable		 5l6eA-5m28A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 ASP B 100
ASN B 111
ASN B 103
GLN B 106
 None
EDO  B 615 (-3.2A)
None
None
 1.16A 5l6eA-5m99B:
undetectable		 5l6eA-5m99B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mau CHLORITE DISMUTASE

(Cyanothece sp.
PCC 7425) 		no annotation 4 ASP A 140
ARG A   4
ASN A   3
GLN A  53
 None
SO4  A 202 (-3.4A)
None
None
 1.12A 5l6eA-5mauA:
undetectable		 5l6eA-5mauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr5 MATA PROTEIN

(Dictyostelium
discoideum) 		no annotation 4 ARG A  83
ASN A  79
ASN A  54
GLN A  53
 None
 1.20A 5l6eA-5nr5A:
undetectable		 5l6eA-5nr5A:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP A 377
ASP A 395
ARG A 536
ASN A 539
ASN A 549
GLN A 550
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-3.7A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.7A)
 0.14A 5l6eA-5teyA:
36.0		 5l6eA-5teyA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF17289
(Terminase_6C) 		4 ASP A 310
ASP A 445
ASN A 383
GLN A 440
 None
 1.15A 5l6eA-5tgeA:
undetectable		 5l6eA-5tgeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 ASP A 461
ASP A 502
ARG A 500
ASN A 460
 None
 1.07A 5l6eA-5u1sA:
2.2		 5l6eA-5u1sA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04084
(ORC2) 		4 ASP B 428
ARG B 323
ASN B 324
ASN B 426
 None
 1.16A 5l6eA-5v8fB:
undetectable		 5l6eA-5v8fB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens;
Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
PF13927
(Ig_3) 		4 ASP A 455
ARG A 310
ASN A 420
GLN C  76
 None
NAG  A 702 (-4.0A)
NAG  A 701 (-1.8A)
None
 1.29A 5l6eA-5vxzA:
undetectable		 5l6eA-5vxzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wte VP3

(Hepatovirus A) 		PF00073
(Rhv) 		4 ASP C 178
ASP C  82
ARG C 185
ASN C 184
 None
 1.24A 5l6eA-5wteC:
undetectable		 5l6eA-5wteC:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 ASP Z  71
ASP Z  87
ASN Z  93
GLN Z  66
 None
 1.14A 5l6eA-5wtiZ:
undetectable		 5l6eA-5wtiZ:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		4 ASP w 119
ARG w 130
ASN w 111
ASN w 127
 None
 1.24A 5l6eA-5xtdw:
undetectable		 5l6eA-5xtdw:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 ASP A1194
ASP A1186
ASN A1196
GLN A1165
 CA  A1705 (-2.2A)
None
None
None
 1.23A 5l6eA-5xyaA:
undetectable		 5l6eA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84

(Saccharomyces
cerevisiae) 		no annotation 4 ASP H 642
ASP H 696
ASN H 638
GLN H 634
 None
 1.03A 5l6eA-5yfpH:
undetectable		 5l6eA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 ASP A 103
ASN A 109
ASN A 142
GLN A 888
 None
 1.02A 5l6eA-6cv9A:
undetectable		 5l6eA-6cv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 ASP A 307
ARG A 154
ASN A 150
ASN A  26
 None
 1.30A 5l6eA-6d5iA:
undetectable		 5l6eA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 ASP A 512
ASN A 560
ASN A 563
GLN A 566
 C  V   9 ( 4.4A)
U  V   3 ( 4.2A)
None
A  V   4 ( 2.8A)
 0.99A 5l6eA-6f5oA:
undetectable		 5l6eA-6f5oA:
undetectable