SIMILAR PATTERNS OF AMINO ACIDS FOR 5L6E_A_SAMA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 SER A  38
HIS A  37
PHE A  61
GLY A  62
GLY A 193
 None
 0.88A 5l6eA-1brtA:
1.5		 5l6eA-1brtA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 ILE A  82
LEU A  98
SER A  58
GLY A 129
GLY A 143
 None
 1.00A 5l6eA-1c3nA:
undetectable		 5l6eA-1c3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 ARG A  30
LEU A 326
GLY A 105
HIS A 101
GLY A  61
 None
 1.07A 5l6eA-1icpA:
undetectable		 5l6eA-1icpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A 282
PHE A 306
GLY A 307
HIS A 331
GLY A 254
 None
 1.00A 5l6eA-1ksiA:
undetectable		 5l6eA-1ksiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 ARG A 320
PRO A 275
LEU A 112
GLY A 198
GLY A 154
 None
None
ACT  A1866 (-4.1A)
None
ODP  A2458 ( 3.4A)
 1.17A 5l6eA-1lqtA:
undetectable		 5l6eA-1lqtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A  39
ARG A  59
LEU A  64
SER A  80
GLY A   7
 None
None
None
None
NAD  A1001 (-3.5A)
 1.13A 5l6eA-1muuA:
undetectable		 5l6eA-1muuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PRO A 488
GLU A 455
PHE A 783
GLY A 784
GLY A 792
 None
 1.18A 5l6eA-1ofeA:
undetectable		 5l6eA-1ofeA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 119
ARG A 117
LEU A 190
GLY A 178
GLY A 120
 None
 1.18A 5l6eA-1oi7A:
undetectable		 5l6eA-1oi7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		6 ILE A  22
ARG A 114
LEU A 176
GLY A 172
HIS A  47
GLY A  34
 None
 1.50A 5l6eA-1p3cA:
undetectable		 5l6eA-1p3cA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		5 ILE A 335
LEU A 417
GLU A  27
GLY A  21
GLY A 272
 None
 1.09A 5l6eA-1p9bA:
undetectable		 5l6eA-1p9bA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)

(Sulfolobus
acidocaldarius) 		PF00719
(Pyrophosphatase) 		5 ILE A1102
SER A1150
GLU A1157
GLY A1153
GLY A1088
 None
 1.09A 5l6eA-1qezA:
undetectable		 5l6eA-1qezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ILE B 439
LEU B 493
GLY B 466
HIS B 104
GLY B 440
 None
 1.03A 5l6eA-1qh1B:
undetectable		 5l6eA-1qh1B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 283
PHE A 287
GLY A 288
HIS A 292
GLY A 286
 HEA  A 602 ( 4.3A)
None
None
None
None
 1.18A 5l6eA-1qleA:
undetectable		 5l6eA-1qleA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PRO B 288
LEU B 281
PHE B 316
GLY B 317
GLY B 313
 None
 1.07A 5l6eA-1tqyB:
undetectable		 5l6eA-1tqyB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 365
PRO A 357
GLU A 323
GLY A 350
HIS A 189
 None
 1.09A 5l6eA-1ulqA:
undetectable		 5l6eA-1ulqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  64
SER A 116
HIS A 124
GLY A 127
GLY A 128
 None
 1.04A 5l6eA-1uufA:
2.0		 5l6eA-1uufA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ILE A 445
LEU A 161
PHE A 413
GLY A 412
GLY A 426
 None
 1.04A 5l6eA-1vcjA:
undetectable		 5l6eA-1vcjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 SER A  55
PHE A 200
GLY A   6
HIS A   8
GLY A 201
 None
 1.15A 5l6eA-1zswA:
undetectable		 5l6eA-1zswA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 PRO A  94
LEU A  87
PHE A 116
GLY A 114
GLY A 112
 GOL  A 820 ( 4.3A)
None
None
GOL  A 825 ( 3.8A)
GOL  A 825 (-3.6A)
 1.16A 5l6eA-2a7mA:
undetectable		 5l6eA-2a7mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ILE B 443
LEU B 497
GLY B 470
HIS B 106
GLY B 444
 None
 1.02A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 LEU B 497
SER B 482
GLY B 470
HIS B 106
GLY B 444
 None
 0.94A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 5 ILE B   4
LEU B 229
SER B 220
GLY B   8
GLY B   6
 None
 1.10A 5l6eA-2d4aB:
undetectable		 5l6eA-2d4aB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 ILE A 331
LEU A 343
SER A 374
GLY A 337
GLY A 333
 None
 1.07A 5l6eA-2d6fA:
undetectable		 5l6eA-2d6fA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 128
ARG A 126
SER A 181
LYS A 153
GLY A 185
 None
 1.14A 5l6eA-2fpgA:
undetectable		 5l6eA-2fpgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		5 ILE A  22
LEU A 137
PHE A  32
GLY A  30
GLY A  28
 None
None
EDO  A 502 (-3.9A)
None
None
 1.02A 5l6eA-2gfgA:
undetectable		 5l6eA-2gfgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 185
SER A 249
PHE A 241
GLY A 252
GLY A 240
 None
 1.07A 5l6eA-2glxA:
undetectable		 5l6eA-2glxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ILE A 332
PRO A 400
LEU A 392
PHE A 341
GLY A 339
 None
 1.18A 5l6eA-2hnhA:
undetectable		 5l6eA-2hnhA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		5 ILE A 155
LEU A 193
GLU A 110
GLY A 113
GLY A 151
 None
 1.09A 5l6eA-2iqtA:
undetectable		 5l6eA-2iqtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		5 ILE A 266
PRO A 281
LEU A 268
PHE A 251
GLY A 252
 None
 1.05A 5l6eA-2o04A:
undetectable		 5l6eA-2o04A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 ILE A 423
LEU A 587
GLU A 599
GLY A 595
GLY A 425
 None
 1.00A 5l6eA-2o1sA:
undetectable		 5l6eA-2o1sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE

(Thermus
thermophilus) 		PF00300
(His_Phos_1) 		5 ILE A  75
LEU A  96
PHE A  77
GLY A  78
GLY A 107
 None
 1.17A 5l6eA-2p2yA:
undetectable		 5l6eA-2p2yA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		5 ARG O  17
LEU O  44
PHE O   8
GLY O   7
GLY O  12
 None
None
None
NDP  O 363 ( 3.7A)
None
 1.07A 5l6eA-2pkqO:
undetectable		 5l6eA-2pkqO:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 374
SER A  52
GLU A 290
GLY A 292
GLY A 295
 None
 1.16A 5l6eA-2ppgA:
undetectable		 5l6eA-2ppgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		5 ARG A  26
LEU A 322
GLY A 101
HIS A  97
GLY A  57
 None
 1.12A 5l6eA-2q3rA:
undetectable		 5l6eA-2q3rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 5 ILE A  86
PRO A  38
PHE A  40
GLY A  11
GLY A  83
 None
 1.09A 5l6eA-2qjwA:
1.7		 5l6eA-2qjwA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		5 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.92A 5l6eA-2rciA:
undetectable		 5l6eA-2rciA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 ILE A 171
LEU A 168
PHE A  27
GLY A  26
GLY A 158
 None
 1.06A 5l6eA-2vidA:
undetectable		 5l6eA-2vidA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A 229
HIS A 159
GLU A 182
PHE A 183
GLY A 222
 None
FE2  A 402 ( 3.3A)
None
None
None
 1.05A 5l6eA-2vw8A:
undetectable		 5l6eA-2vw8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PRO A 303
SER A 375
HIS A 377
PHE A 304
GLY A  89
 HMG  A1509 (-3.7A)
None
None
HMG  A1509 (-4.1A)
None
 0.98A 5l6eA-2wyaA:
undetectable		 5l6eA-2wyaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90

(Hordeum vulgare) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ILE A 119
LEU A 110
PHE A 106
GLY A 123
GLY A 120
 None
None
None
ADP  A1211 (-2.9A)
MG  A1212 ( 4.9A)
 1.18A 5l6eA-2xcmA:
undetectable		 5l6eA-2xcmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 ILE A 375
LEU A 628
HIS A 244
GLY A 351
HIS A 329
 None
None
ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.5A)
 1.00A 5l6eA-2xr1A:
undetectable		 5l6eA-2xr1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		5 ILE A 171
PRO A  29
PHE A 147
GLY A 148
GLY A 173
 None
PAJ  A 501 (-4.6A)
PAJ  A 501 (-4.6A)
PAJ  A 501 (-3.1A)
None
 1.13A 5l6eA-3ag6A:
undetectable		 5l6eA-3ag6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 PRO A 169
LEU A 161
SER A 174
PHE A 198
GLY A 199
 None
 1.11A 5l6eA-3aupA:
undetectable		 5l6eA-3aupA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ILE B  32
PRO B 295
SER B 302
GLY B  86
GLY B  33
 None
 1.01A 5l6eA-3blxB:
undetectable		 5l6eA-3blxB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		5 ILE A1293
LEU A1450
GLU A1397
PHE A1295
GLY A1296
 None
 1.17A 5l6eA-3eujA:
undetectable		 5l6eA-3eujA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		5 ILE A 157
PRO A 178
GLY A 152
HIS A 148
GLY A 154
 MG  A 283 ( 4.9A)
MG  A 283 (-4.2A)
None
None
None
 1.07A 5l6eA-3fcxA:
undetectable		 5l6eA-3fcxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 222
ARG A 198
PRO A 247
GLY A 219
GLY A 221
 None
 1.13A 5l6eA-3fj4A:
undetectable		 5l6eA-3fj4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		5 ILE A 481
LEU A 502
SER A 334
HIS A 336
GLY A 479
 None
 1.17A 5l6eA-3ftjA:
undetectable		 5l6eA-3ftjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ILE A 604
HIS A 344
PHE A 586
GLY A 584
GLY A 602
 None
GOL  A   1 (-4.1A)
None
None
None
 1.17A 5l6eA-3gm8A:
undetectable		 5l6eA-3gm8A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 352
PRO A 344
GLU A 309
GLY A 337
HIS A 173
 None
 1.15A 5l6eA-3goaA:
undetectable		 5l6eA-3goaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		5 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
None
CL  A 388 ( 4.9A)
None
None
 0.93A 5l6eA-3k2kA:
undetectable		 5l6eA-3k2kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 ILE A 408
LYS A 237
GLY A 403
HIS A 378
GLY A 407
 None
 1.04A 5l6eA-3k9dA:
undetectable		 5l6eA-3k9dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 ILE A 100
PRO A  64
LEU A  26
PHE A  96
GLY A  95
 None
None
GOL  A 302 (-4.9A)
None
None
 1.17A 5l6eA-3lupA:
undetectable		 5l6eA-3lupA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		5 ARG A 280
HIS A 139
PHE A 273
GLY A 201
GLY A 274
 None
None
None
EDO  A 417 (-3.3A)
None
 0.95A 5l6eA-3mveA:
undetectable		 5l6eA-3mveA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nul PROFILIN I

(Arabidopsis
thaliana) 		PF00235
(Profilin) 		5 PRO A  40
LEU A  42
PHE A  39
HIS A  19
GLY A 104
 None
 1.10A 5l6eA-3nulA:
undetectable		 5l6eA-3nulA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		5 ILE A  50
LEU A  92
SER A  18
GLY A  10
HIS A  15
 None
 1.10A 5l6eA-3phgA:
2.1		 5l6eA-3phgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		5 ILE A 127
SER A 116
GLU A 122
PHE A 123
GLY A 125
 None
 1.14A 5l6eA-3r31A:
0.7		 5l6eA-3r31A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 292
PRO A  80
LEU A 296
PHE A  55
GLY A   4
 None
 1.12A 5l6eA-3r5xA:
undetectable		 5l6eA-3r5xA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 430
LEU A 189
SER A 466
GLY A 456
GLY A 397
 None
 1.15A 5l6eA-3uk1A:
undetectable		 5l6eA-3uk1A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		5 ILE B 233
LEU B 270
SER B 201
HIS B 187
GLY B 231
 None
 1.12A 5l6eA-3zheB:
undetectable		 5l6eA-3zheB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 SER A 292
HIS A 291
GLY A 252
HIS A 182
GLY A 188
 None
PO4  A1365 (-3.8A)
None
ZN  A1364 ( 3.5A)
None
 1.18A 5l6eA-3zwfA:
undetectable		 5l6eA-3zwfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		5 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
 0.97A 5l6eA-4b6zA:
undetectable		 5l6eA-4b6zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 347
HIS A 587
GLU A 646
GLY A 394
GLY A 398
 None
 1.14A 5l6eA-4cakA:
undetectable		 5l6eA-4cakA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ILE A 444
LEU A 160
PHE A 412
GLY A 411
GLY A 425
 None
 1.13A 5l6eA-4cpnA:
undetectable		 5l6eA-4cpnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 LEU A 224
LYS A 205
GLU A 202
GLY A 199
GLY A 195
 None
None
None
None
LLP  A  58 ( 3.8A)
 1.15A 5l6eA-4il5A:
undetectable		 5l6eA-4il5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 SER A  38
HIS A  37
PHE A  61
GLY A  62
GLY A 193
 None
 0.93A 5l6eA-4iq4A:
undetectable		 5l6eA-4iq4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 SER A 220
HIS A 338
GLU A 287
GLY A 336
GLY A 334
 None
None
MG  A 409 (-3.3A)
MG  A 409 (-3.9A)
BR8  A 401 (-3.6A)
 1.09A 5l6eA-4nq3A:
undetectable		 5l6eA-4nq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 ILE A 121
PRO A  72
LEU A  97
GLY A  49
GLY A 118
 None
 1.15A 5l6eA-4ns4A:
undetectable		 5l6eA-4ns4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ILE A 116
SER A  46
GLY A 105
HIS A 101
GLY A 109
 None
None
None
ZN  A 301 (-3.4A)
None
 1.01A 5l6eA-4o1jA:
undetectable		 5l6eA-4o1jA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens;
Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 LEU A 213
SER C  79
HIS C  76
GLU A 268
PHE A 267
 None
 1.12A 5l6eA-4owtA:
undetectable		 5l6eA-4owtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ILE A 229
PRO A 238
LEU A 244
GLY A 235
GLY A 231
 None
 0.93A 5l6eA-4q0mA:
undetectable		 5l6eA-4q0mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 PRO A  71
SER A 132
HIS A 131
GLY A 128
GLY A  43
 None
None
MN  A 401 ( 3.2A)
None
None
 1.13A 5l6eA-4q3rA:
1.6		 5l6eA-4q3rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 5 ILE B 229
PRO B 238
LEU B 244
GLY B 235
GLY B 231
 None
 0.99A 5l6eA-4ra6B:
undetectable		 5l6eA-4ra6B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ILE A  21
LEU A 184
SER A 121
GLY A  16
GLY A  22
 NAD  A 301 (-3.9A)
None
None
NAD  A 301 (-3.1A)
None
 1.16A 5l6eA-4wecA:
1.9		 5l6eA-4wecA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		5 ILE A  43
PRO A 247
LEU A 264
GLU A  36
GLY A  41
 None
 1.17A 5l6eA-4wepA:
undetectable		 5l6eA-4wepA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.04A 5l6eA-4xxnA:
undetectable		 5l6eA-4xxnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.00A 5l6eA-4xy3A:
undetectable		 5l6eA-4xy3A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Grosmannia
penicillata) 		PF00961
(LAGLIDADG_1) 		5 ILE A 264
LEU A 268
GLU A  19
GLY A 182
GLY A 178
 None
None
CA  A 402 ( 2.8A)
CA  A 403 (-3.8A)
None
 1.17A 5l6eA-4yhxA:
undetectable		 5l6eA-4yhxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 ILE A 252
GLU A 286
PHE A 287
HIS A 325
GLY A 227
 None
None
None
ZN  A 343 (-3.3A)
None
 0.97A 5l6eA-5a89A:
undetectable		 5l6eA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		5 ILE A 119
PRO A  99
LEU A  61
PHE A 163
GLY A 164
 None
None
None
None
GTP  A1250 (-3.3A)
 1.15A 5l6eA-5a96A:
undetectable		 5l6eA-5a96A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 5 ILE A  44
PRO A 108
PHE A  46
GLY A  47
GLY A 246
 None
 1.09A 5l6eA-5avpA:
undetectable		 5l6eA-5avpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus) 		PF07245
(Phlebovirus_G2) 		5 ILE A 886
PRO A 730
LEU A 627
SER A 750
GLY A 888
 None
 1.19A 5l6eA-5g47A:
undetectable		 5l6eA-5g47A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		8 ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
GLY A 535
GLY A 548
 None
 0.40A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 ILE A 378
HIS A 538
GLU A 532
GLY A 535
GLY A 548
 None
 0.97A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 225
ARG A 385
LEU A 276
GLY A 216
GLY A 219
 None
 1.09A 5l6eA-5jp0A:
undetectable		 5l6eA-5jp0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 None
 0.71A 5l6eA-5k7mB:
20.5		 5l6eA-5k7mB:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 ARG A 172
LEU A 111
PHE A 225
GLY A 224
GLY A 145
 None
 0.97A 5l6eA-5kelA:
undetectable		 5l6eA-5kelA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 None
 0.84A 5l6eA-5l6eB:
20.3		 5l6eA-5l6eB:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 ILE A 469
LEU A 561
PHE A 465
GLY A 464
GLY A 467
 None
 1.02A 5l6eA-5lq3A:
undetectable		 5l6eA-5lq3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 PRO A 238
LEU A 348
GLU A 301
PHE A 237
GLY A 300
 None
 1.14A 5l6eA-5mlhA:
2.2		 5l6eA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 5 LEU A 466
GLU A 494
PHE A 495
HIS A 532
GLY A 529
 None
None
None
SEP  C 732 ( 4.9A)
None
 0.97A 5l6eA-5n7fA:
undetectable		 5l6eA-5n7fA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ARG A1710
HIS A1810
GLU A1682
GLY A1874
GLY A1660
 None
 1.18A 5l6eA-5nugA:
undetectable		 5l6eA-5nugA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4u FLAGELLIN

(Pyrococcus
furiosus) 		PF01917
(Arch_flagellin) 		5 ILE A 176
LEU A  96
PHE A 172
GLY A 173
GLY A 175
 None
 1.18A 5l6eA-5o4uA:
undetectable		 5l6eA-5o4uA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		12 ILE A 378
ARG A 379
PRO A 397
LEU A 409
SER A 511
HIS A 512
LYS A 513
GLU A 532
PHE A 534
GLY A 535
HIS A 538
GLY A 548
 SAH  A 601 (-3.9A)
SAH  A 601 ( 4.7A)
SAH  A 601 (-4.3A)
None
SAH  A 601 (-4.6A)
SAH  A 601 (-4.6A)
SAH  A 601 (-4.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-4.7A)
SAH  A 601 ( 4.6A)
SAH  A 601 (-4.0A)
SAH  A 601 ( 3.8A)
 0.06A 5l6eA-5teyA:
36.0		 5l6eA-5teyA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 UNX  B 407 ( 4.2A)
None
None
None
None
None
 0.79A 5l6eA-5teyB:
19.9		 5l6eA-5teyB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ILE A 265
SER A 166
HIS A  83
PHE A 180
GLY A 271
 None
None
TPO  A  79 ( 4.1A)
None
None
 1.08A 5l6eA-5tj3A:
undetectable		 5l6eA-5tj3A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 331
HIS A 428
GLU A 321
PHE A 319
GLY A 318
 None
 0.91A 5l6eA-5toaA:
undetectable		 5l6eA-5toaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 ILE A 204
PRO A 232
LEU A 225
GLY A 237
GLY A 405
 None
 1.15A 5l6eA-5xbpA:
undetectable		 5l6eA-5xbpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 ILE A 403
LEU A 394
GLU A 462
PHE A 461
GLY A 459
 None
 1.13A 5l6eA-6b5cA:
undetectable		 5l6eA-6b5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ILE A 495
SER A 327
HIS A 329
PHE A 169
GLY A 168
 None
None
ZN  A 901 ( 3.3A)
None
None
 1.10A 5l6eA-6c01A:
undetectable		 5l6eA-6c01A:
undetectable