SIMILAR PATTERNS OF AMINO ACIDS FOR 5L6E_A_SAMA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 SER A  38
HIS A  37
PHE A  61
GLY A  62
GLY A 193
 None
 0.88A 5l6eA-1brtA:
1.5		 5l6eA-1brtA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 ILE A  82
LEU A  98
SER A  58
GLY A 129
GLY A 143
 None
 1.00A 5l6eA-1c3nA:
undetectable		 5l6eA-1c3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 ARG A  30
LEU A 326
GLY A 105
HIS A 101
GLY A  61
 None
 1.07A 5l6eA-1icpA:
undetectable		 5l6eA-1icpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A 282
PHE A 306
GLY A 307
HIS A 331
GLY A 254
 None
 1.00A 5l6eA-1ksiA:
undetectable		 5l6eA-1ksiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 ARG A 320
PRO A 275
LEU A 112
GLY A 198
GLY A 154
 None
None
ACT  A1866 (-4.1A)
None
ODP  A2458 ( 3.4A)
 1.17A 5l6eA-1lqtA:
undetectable		 5l6eA-1lqtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A  39
ARG A  59
LEU A  64
SER A  80
GLY A   7
 None
None
None
None
NAD  A1001 (-3.5A)
 1.13A 5l6eA-1muuA:
undetectable		 5l6eA-1muuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PRO A 488
GLU A 455
PHE A 783
GLY A 784
GLY A 792
 None
 1.18A 5l6eA-1ofeA:
undetectable		 5l6eA-1ofeA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 119
ARG A 117
LEU A 190
GLY A 178
GLY A 120
 None
 1.18A 5l6eA-1oi7A:
undetectable		 5l6eA-1oi7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		6 ILE A  22
ARG A 114
LEU A 176
GLY A 172
HIS A  47
GLY A  34
 None
 1.50A 5l6eA-1p3cA:
undetectable		 5l6eA-1p3cA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		5 ILE A 335
LEU A 417
GLU A  27
GLY A  21
GLY A 272
 None
 1.09A 5l6eA-1p9bA:
undetectable		 5l6eA-1p9bA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)

(Sulfolobus
acidocaldarius) 		PF00719
(Pyrophosphatase) 		5 ILE A1102
SER A1150
GLU A1157
GLY A1153
GLY A1088
 None
 1.09A 5l6eA-1qezA:
undetectable		 5l6eA-1qezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ILE B 439
LEU B 493
GLY B 466
HIS B 104
GLY B 440
 None
 1.03A 5l6eA-1qh1B:
undetectable		 5l6eA-1qh1B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 283
PHE A 287
GLY A 288
HIS A 292
GLY A 286
 HEA  A 602 ( 4.3A)
None
None
None
None
 1.18A 5l6eA-1qleA:
undetectable		 5l6eA-1qleA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PRO B 288
LEU B 281
PHE B 316
GLY B 317
GLY B 313
 None
 1.07A 5l6eA-1tqyB:
undetectable		 5l6eA-1tqyB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 365
PRO A 357
GLU A 323
GLY A 350
HIS A 189
 None
 1.09A 5l6eA-1ulqA:
undetectable		 5l6eA-1ulqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  64
SER A 116
HIS A 124
GLY A 127
GLY A 128
 None
 1.04A 5l6eA-1uufA:
2.0		 5l6eA-1uufA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ILE A 445
LEU A 161
PHE A 413
GLY A 412
GLY A 426
 None
 1.04A 5l6eA-1vcjA:
undetectable		 5l6eA-1vcjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 SER A  55
PHE A 200
GLY A   6
HIS A   8
GLY A 201
 None
 1.15A 5l6eA-1zswA:
undetectable		 5l6eA-1zswA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 PRO A  94
LEU A  87
PHE A 116
GLY A 114
GLY A 112
 GOL  A 820 ( 4.3A)
None
None
GOL  A 825 ( 3.8A)
GOL  A 825 (-3.6A)
 1.16A 5l6eA-2a7mA:
undetectable		 5l6eA-2a7mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ILE B 443
LEU B 497
GLY B 470
HIS B 106
GLY B 444
 None
 1.02A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 LEU B 497
SER B 482
GLY B 470
HIS B 106
GLY B 444
 None
 0.94A 5l6eA-2afhB:
2.2		 5l6eA-2afhB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 5 ILE B   4
LEU B 229
SER B 220
GLY B   8
GLY B   6
 None
 1.10A 5l6eA-2d4aB:
undetectable		 5l6eA-2d4aB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 ILE A 331
LEU A 343
SER A 374
GLY A 337
GLY A 333
 None
 1.07A 5l6eA-2d6fA:
undetectable		 5l6eA-2d6fA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 128
ARG A 126
SER A 181
LYS A 153
GLY A 185
 None
 1.14A 5l6eA-2fpgA:
undetectable		 5l6eA-2fpgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		5 ILE A  22
LEU A 137
PHE A  32
GLY A  30
GLY A  28
 None
None
EDO  A 502 (-3.9A)
None
None
 1.02A 5l6eA-2gfgA:
undetectable		 5l6eA-2gfgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 185
SER A 249
PHE A 241
GLY A 252
GLY A 240
 None
 1.07A 5l6eA-2glxA:
undetectable		 5l6eA-2glxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ILE A 332
PRO A 400
LEU A 392
PHE A 341
GLY A 339
 None
 1.18A 5l6eA-2hnhA:
undetectable		 5l6eA-2hnhA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		5 ILE A 155
LEU A 193
GLU A 110
GLY A 113
GLY A 151
 None
 1.09A 5l6eA-2iqtA:
undetectable		 5l6eA-2iqtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		5 ILE A 266
PRO A 281
LEU A 268
PHE A 251
GLY A 252
 None
 1.05A 5l6eA-2o04A:
undetectable		 5l6eA-2o04A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 ILE A 423
LEU A 587
GLU A 599
GLY A 595
GLY A 425
 None
 1.00A 5l6eA-2o1sA:
undetectable		 5l6eA-2o1sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE

(Thermus
thermophilus) 		PF00300
(His_Phos_1) 		5 ILE A  75
LEU A  96
PHE A  77
GLY A  78
GLY A 107
 None
 1.17A 5l6eA-2p2yA:
undetectable		 5l6eA-2p2yA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		5 ARG O  17
LEU O  44
PHE O   8
GLY O   7
GLY O  12
 None
None
None
NDP  O 363 ( 3.7A)
None
 1.07A 5l6eA-2pkqO:
undetectable		 5l6eA-2pkqO:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 374
SER A  52
GLU A 290
GLY A 292
GLY A 295
 None
 1.16A 5l6eA-2ppgA:
undetectable		 5l6eA-2ppgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		5 ARG A  26
LEU A 322
GLY A 101
HIS A  97
GLY A  57
 None
 1.12A 5l6eA-2q3rA:
undetectable		 5l6eA-2q3rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 5 ILE A  86
PRO A  38
PHE A  40
GLY A  11
GLY A  83
 None
 1.09A 5l6eA-2qjwA:
1.7		 5l6eA-2qjwA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		5 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.92A 5l6eA-2rciA:
undetectable		 5l6eA-2rciA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 ILE A 171
LEU A 168
PHE A  27
GLY A  26
GLY A 158
 None
 1.06A 5l6eA-2vidA:
undetectable		 5l6eA-2vidA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A 229
HIS A 159
GLU A 182
PHE A 183
GLY A 222
 None
FE2  A 402 ( 3.3A)
None
None
None
 1.05A 5l6eA-2vw8A:
undetectable		 5l6eA-2vw8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PRO A 303
SER A 375
HIS A 377
PHE A 304
GLY A  89
 HMG  A1509 (-3.7A)
None
None
HMG  A1509 (-4.1A)
None
 0.98A 5l6eA-2wyaA:
undetectable		 5l6eA-2wyaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90

(Hordeum vulgare) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ILE A 119
LEU A 110
PHE A 106
GLY A 123
GLY A 120
 None
None
None
ADP  A1211 (-2.9A)
MG  A1212 ( 4.9A)
 1.18A 5l6eA-2xcmA:
undetectable		 5l6eA-2xcmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 ILE A 375
LEU A 628
HIS A 244
GLY A 351
HIS A 329
 None
None
ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.5A)
 1.00A 5l6eA-2xr1A:
undetectable		 5l6eA-2xr1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		5 ILE A 171
PRO A  29
PHE A 147
GLY A 148
GLY A 173
 None
PAJ  A 501 (-4.6A)
PAJ  A 501 (-4.6A)
PAJ  A 501 (-3.1A)
None
 1.13A 5l6eA-3ag6A:
undetectable		 5l6eA-3ag6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 PRO A 169
LEU A 161
SER A 174
PHE A 198
GLY A 199
 None
 1.11A 5l6eA-3aupA:
undetectable		 5l6eA-3aupA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ILE B  32
PRO B 295
SER B 302
GLY B  86
GLY B  33
 None
 1.01A 5l6eA-3blxB:
undetectable		 5l6eA-3blxB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		5 ILE A1293
LEU A1450
GLU A1397
PHE A1295
GLY A1296
 None
 1.17A 5l6eA-3eujA:
undetectable		 5l6eA-3eujA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		5 ILE A 157
PRO A 178
GLY A 152
HIS A 148
GLY A 154
 MG  A 283 ( 4.9A)
MG  A 283 (-4.2A)
None
None
None
 1.07A 5l6eA-3fcxA:
undetectable		 5l6eA-3fcxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 222
ARG A 198
PRO A 247
GLY A 219
GLY A 221
 None
 1.13A 5l6eA-3fj4A:
undetectable		 5l6eA-3fj4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		5 ILE A 481
LEU A 502
SER A 334
HIS A 336
GLY A 479
 None
 1.17A 5l6eA-3ftjA:
undetectable		 5l6eA-3ftjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ILE A 604
HIS A 344
PHE A 586
GLY A 584
GLY A 602
 None
GOL  A   1 (-4.1A)
None
None
None
 1.17A 5l6eA-3gm8A:
undetectable		 5l6eA-3gm8A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 352
PRO A 344
GLU A 309
GLY A 337
HIS A 173
 None
 1.15A 5l6eA-3goaA:
undetectable		 5l6eA-3goaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		5 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
None
CL  A 388 ( 4.9A)
None
None
 0.93A 5l6eA-3k2kA:
undetectable		 5l6eA-3k2kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 ILE A 408
LYS A 237
GLY A 403
HIS A 378
GLY A 407
 None
 1.04A 5l6eA-3k9dA:
undetectable		 5l6eA-3k9dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		5 ILE A 100
PRO A  64
LEU A  26
PHE A  96
GLY A  95
 None
None
GOL  A 302 (-4.9A)
None
None
 1.17A 5l6eA-3lupA:
undetectable		 5l6eA-3lupA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		5 ARG A 280
HIS A 139
PHE A 273
GLY A 201
GLY A 274
 None
None
None
EDO  A 417 (-3.3A)
None
 0.95A 5l6eA-3mveA:
undetectable		 5l6eA-3mveA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nul PROFILIN I

(Arabidopsis
thaliana) 		PF00235
(Profilin) 		5 PRO A  40
LEU A  42
PHE A  39
HIS A  19
GLY A 104
 None
 1.10A 5l6eA-3nulA:
undetectable		 5l6eA-3nulA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		5 ILE A  50
LEU A  92
SER A  18
GLY A  10
HIS A  15
 None
 1.10A 5l6eA-3phgA:
2.1		 5l6eA-3phgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		5 ILE A 127
SER A 116
GLU A 122
PHE A 123
GLY A 125
 None
 1.14A 5l6eA-3r31A:
0.7		 5l6eA-3r31A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 292
PRO A  80
LEU A 296
PHE A  55
GLY A   4
 None
 1.12A 5l6eA-3r5xA:
undetectable		 5l6eA-3r5xA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 430
LEU A 189
SER A 466
GLY A 456
GLY A 397
 None
 1.15A 5l6eA-3uk1A:
undetectable		 5l6eA-3uk1A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		5 ILE B 233
LEU B 270
SER B 201
HIS B 187
GLY B 231
 None
 1.12A 5l6eA-3zheB:
undetectable		 5l6eA-3zheB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 SER A 292
HIS A 291
GLY A 252
HIS A 182
GLY A 188
 None
PO4  A1365 (-3.8A)
None
ZN  A1364 ( 3.5A)
None
 1.18A 5l6eA-3zwfA:
undetectable		 5l6eA-3zwfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		5 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
 0.97A 5l6eA-4b6zA:
undetectable		 5l6eA-4b6zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 347
HIS A 587
GLU A 646
GLY A 394
GLY A 398
 None
 1.14A 5l6eA-4cakA:
undetectable		 5l6eA-4cakA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ILE A 444
LEU A 160
PHE A 412
GLY A 411
GLY A 425
 None
 1.13A 5l6eA-4cpnA:
undetectable		 5l6eA-4cpnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 LEU A 224
LYS A 205
GLU A 202
GLY A 199
GLY A 195
 None
None
None
None
LLP  A  58 ( 3.8A)
 1.15A 5l6eA-4il5A:
undetectable		 5l6eA-4il5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 SER A  38
HIS A  37
PHE A  61
GLY A  62
GLY A 193
 None
 0.93A 5l6eA-4iq4A:
undetectable		 5l6eA-4iq4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 SER A 220
HIS A 338
GLU A 287
GLY A 336
GLY A 334
 None
None
MG  A 409 (-3.3A)
MG  A 409 (-3.9A)
BR8  A 401 (-3.6A)
 1.09A 5l6eA-4nq3A:
undetectable		 5l6eA-4nq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 ILE A 121
PRO A  72
LEU A  97
GLY A  49
GLY A 118
 None
 1.15A 5l6eA-4ns4A:
undetectable		 5l6eA-4ns4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ILE A 116
SER A  46
GLY A 105
HIS A 101
GLY A 109
 None
None
None
ZN  A 301 (-3.4A)
None
 1.01A 5l6eA-4o1jA:
undetectable		 5l6eA-4o1jA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens;
Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 LEU A 213
SER C  79
HIS C  76
GLU A 268
PHE A 267
 None
 1.12A 5l6eA-4owtA:
undetectable		 5l6eA-4owtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ILE A 229
PRO A 238
LEU A 244
GLY A 235
GLY A 231
 None
 0.93A 5l6eA-4q0mA:
undetectable		 5l6eA-4q0mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 PRO A  71
SER A 132
HIS A 131
GLY A 128
GLY A  43
 None
None
MN  A 401 ( 3.2A)
None
None
 1.13A 5l6eA-4q3rA:
1.6		 5l6eA-4q3rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 5 ILE B 229
PRO B 238
LEU B 244
GLY B 235
GLY B 231
 None
 0.99A 5l6eA-4ra6B:
undetectable		 5l6eA-4ra6B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ILE A  21
LEU A 184
SER A 121
GLY A  16
GLY A  22
 NAD  A 301 (-3.9A)
None
None
NAD  A 301 (-3.1A)
None
 1.16A 5l6eA-4wecA:
1.9		 5l6eA-4wecA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		5 ILE A  43
PRO A 247
LEU A 264
GLU A  36
GLY A  41
 None
 1.17A 5l6eA-4wepA:
undetectable		 5l6eA-4wepA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.04A 5l6eA-4xxnA:
undetectable		 5l6eA-4xxnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.00A 5l6eA-4xy3A:
undetectable		 5l6eA-4xy3A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Grosmannia
penicillata) 		PF00961
(LAGLIDADG_1) 		5 ILE A 264
LEU A 268
GLU A  19
GLY A 182
GLY A 178
 None
None
CA  A 402 ( 2.8A)
CA  A 403 (-3.8A)
None
 1.17A 5l6eA-4yhxA:
undetectable		 5l6eA-4yhxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 ILE A 252
GLU A 286
PHE A 287
HIS A 325
GLY A 227
 None
None
None
ZN  A 343 (-3.3A)
None
 0.97A 5l6eA-5a89A:
undetectable		 5l6eA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		5 ILE A 119
PRO A  99
LEU A  61
PHE A 163
GLY A 164
 None
None
None
None
GTP  A1250 (-3.3A)
 1.15A 5l6eA-5a96A:
undetectable		 5l6eA-5a96A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 5 ILE A  44
PRO A 108
PHE A  46
GLY A  47
GLY A 246
 None
 1.09A 5l6eA-5avpA:
undetectable		 5l6eA-5avpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus) 		PF07245
(Phlebovirus_G2) 		5 ILE A 886
PRO A 730
LEU A 627
SER A 750
GLY A 888
 None
 1.19A 5l6eA-5g47A:
undetectable		 5l6eA-5g47A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		8 ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
GLY A 535
GLY A 548
 None
 0.40A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 ILE A 378
HIS A 538
GLU A 532
GLY A 535
GLY A 548
 None
 0.97A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 225
ARG A 385
LEU A 276
GLY A 216
GLY A 219
 None
 1.09A 5l6eA-5jp0A:
undetectable		 5l6eA-5jp0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 None
 0.71A 5l6eA-5k7mB:
20.5		 5l6eA-5k7mB:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 ARG A 172
LEU A 111
PHE A 225
GLY A 224
GLY A 145
 None
 0.97A 5l6eA-5kelA:
undetectable		 5l6eA-5kelA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 None
 0.84A 5l6eA-5l6eB:
20.3		 5l6eA-5l6eB:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 ILE A 469
LEU A 561
PHE A 465
GLY A 464
GLY A 467
 None
 1.02A 5l6eA-5lq3A:
undetectable		 5l6eA-5lq3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 5 PRO A 238
LEU A 348
GLU A 301
PHE A 237
GLY A 300
 None
 1.14A 5l6eA-5mlhA:
2.2		 5l6eA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 5 LEU A 466
GLU A 494
PHE A 495
HIS A 532
GLY A 529
 None
None
None
SEP  C 732 ( 4.9A)
None
 0.97A 5l6eA-5n7fA:
undetectable		 5l6eA-5n7fA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ARG A1710
HIS A1810
GLU A1682
GLY A1874
GLY A1660
 None
 1.18A 5l6eA-5nugA:
undetectable		 5l6eA-5nugA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4u FLAGELLIN

(Pyrococcus
furiosus) 		PF01917
(Arch_flagellin) 		5 ILE A 176
LEU A  96
PHE A 172
GLY A 173
GLY A 175
 None
 1.18A 5l6eA-5o4uA:
undetectable		 5l6eA-5o4uA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		12 ILE A 378
ARG A 379
PRO A 397
LEU A 409
SER A 511
HIS A 512
LYS A 513
GLU A 532
PHE A 534
GLY A 535
HIS A 538
GLY A 548
 SAH  A 601 (-3.9A)
SAH  A 601 ( 4.7A)
SAH  A 601 (-4.3A)
None
SAH  A 601 (-4.6A)
SAH  A 601 (-4.6A)
SAH  A 601 (-4.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-4.7A)
SAH  A 601 ( 4.6A)
SAH  A 601 (-4.0A)
SAH  A 601 ( 3.8A)
 0.06A 5l6eA-5teyA:
36.0		 5l6eA-5teyA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 UNX  B 407 ( 4.2A)
None
None
None
None
None
 0.79A 5l6eA-5teyB:
19.9		 5l6eA-5teyB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ILE A 265
SER A 166
HIS A  83
PHE A 180
GLY A 271
 None
None
TPO  A  79 ( 4.1A)
None
None
 1.08A 5l6eA-5tj3A:
undetectable		 5l6eA-5tj3A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 331
HIS A 428
GLU A 321
PHE A 319
GLY A 318
 None
 0.91A 5l6eA-5toaA:
undetectable		 5l6eA-5toaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 ILE A 204
PRO A 232
LEU A 225
GLY A 237
GLY A 405
 None
 1.15A 5l6eA-5xbpA:
undetectable		 5l6eA-5xbpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 ILE A 403
LEU A 394
GLU A 462
PHE A 461
GLY A 459
 None
 1.13A 5l6eA-6b5cA:
undetectable		 5l6eA-6b5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ILE A 495
SER A 327
HIS A 329
PHE A 169
GLY A 168
 None
None
ZN  A 901 ( 3.3A)
None
None
 1.10A 5l6eA-6c01A:
undetectable		 5l6eA-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 ASP A 195
ASN A  31
ASN A 192
GLN A  62
 None
 1.18A 5l6eA-1a8sA:
1.4		 5l6eA-1a8sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		4 ASP A  21
ASP A 154
ARG A 126
ASN A 164
 None
 1.14A 5l6eA-1b24A:
undetectable		 5l6eA-1b24A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		4 ASP A 354
ASP A 180
ASN A 230
ASN A 310
 None
 1.27A 5l6eA-1bvwA:
undetectable		 5l6eA-1bvwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ASP A 157
ASP A 147
ARG A 137
GLN A 134
 None
 1.14A 5l6eA-1c4kA:
undetectable		 5l6eA-1c4kA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 ASP A 450
ASP A 455
ASN A 451
GLN A  33
 None
 1.16A 5l6eA-1cbgA:
undetectable		 5l6eA-1cbgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 ASP A 155
ARG A 132
ASN A   5
GLN A 183
 None
 1.15A 5l6eA-1dr6A:
undetectable		 5l6eA-1dr6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 ASP M 461
ASN M 466
ASN M 462
GLN M  39
 None
None
None
GOL  M 936 (-3.1A)
 1.01A 5l6eA-1dwaM:
undetectable		 5l6eA-1dwaM:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 ASP A 378
ASP A 506
ARG A 373
GLN A 495
 None
 1.28A 5l6eA-1f0iA:
0.4		 5l6eA-1f0iA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B

(Bacillus
subtilis) 		PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		4 ASP A  31
ASN A  42
ASN A  34
GLN A  37
 None
None
MG  E2001 ( 4.6A)
None
 1.26A 5l6eA-1f51A:
undetectable		 5l6eA-1f51A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 ASP A 125
ASN A 303
ASN A 300
GLN A 298
 None
 1.25A 5l6eA-1fhfA:
undetectable		 5l6eA-1fhfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 ASP A 412
ASP A 170
ASN A 163
GLN A 417
 None
 1.24A 5l6eA-1io1A:
undetectable		 5l6eA-1io1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 ASP A1203
ASP A1119
ASN A1141
ASN A1182
 None
None
None
CA  A2003 (-3.6A)
 1.25A 5l6eA-1jl5A:
undetectable		 5l6eA-1jl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 ASP A  69
ASP A  25
ASN A  23
GLN A  60
 None
 1.03A 5l6eA-1m9iA:
undetectable		 5l6eA-1m9iA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		4 ASP A 131
ASP A 106
ARG A  15
ASN A  19
 None
 1.13A 5l6eA-1n1qA:
undetectable		 5l6eA-1n1qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdk MANNOSE-BINDING
PROTEIN-C

(Rattus rattus) 		PF00059
(Lectin_C) 		4 ASP 1 211
ASN 1 127
ASN 1 199
GLN 1 167
 CA  1   2 (-3.1A)
None
CA  1 227 (-3.4A)
None
 1.27A 5l6eA-1rdk1:
undetectable		 5l6eA-1rdk1:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 ASP A  95
ASP A  63
ARG A 178
ASN A 174
 None
 1.14A 5l6eA-1t6pA:
undetectable		 5l6eA-1t6pA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 ASP A 577
ASP A 721
ARG A 491
GLN A 497
 None
 1.15A 5l6eA-1u2lA:
undetectable		 5l6eA-1u2lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ASP A 169
ASP A 180
ASN A 176
ASN A 168
 None
 1.26A 5l6eA-1udqA:
undetectable		 5l6eA-1udqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9z DNA MISMATCH REPAIR
PROTEIN MUTL

(Escherichia
coli) 		PF08676
(MutL_C) 		4 ARG A 563
ASN A 564
ASN A 556
GLN A 559
 None
 1.24A 5l6eA-1x9zA:
undetectable		 5l6eA-1x9zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ASP A 144
ASP A 203
ARG A 200
ASN A 186
 FE  A 313 (-2.6A)
None
None
None
 1.30A 5l6eA-1xvxA:
undetectable		 5l6eA-1xvxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13420
(Acetyltransf_4) 		4 ASP A  13
ASP A  39
ARG A  43
ASN A  23
 None
None
SO4  A1002 (-3.7A)
None
 1.13A 5l6eA-1yr0A:
undetectable		 5l6eA-1yr0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASP A 391
ASP A  18
ASN A  22
GLN A  27
 None
 1.09A 5l6eA-1z01A:
undetectable		 5l6eA-1z01A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASP A 281
ASP A 238
ASN A 271
GLN A 352
 None
 1.24A 5l6eA-1zuoA:
undetectable		 5l6eA-1zuoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		4 ASP X 297
ASP X  38
ARG X 255
GLN X 311
 None
 0.95A 5l6eA-2ae0X:
undetectable		 5l6eA-2ae0X:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		4 ASP A 540
ASN A 557
ASN A 545
GLN A 585
 None
 1.12A 5l6eA-2ckhA:
undetectable		 5l6eA-2ckhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djq SH3 DOMAIN
CONTAINING RING
FINGER 2

(Mus musculus) 		PF07653
(SH3_2) 		4 ASP A  23
ASP A  39
ARG A  36
GLN A  44
 None
 0.85A 5l6eA-2djqA:
undetectable		 5l6eA-2djqA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f17 THIAMIN
PYROPHOSPHOKINASE 1

(Mus musculus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 ASP A  46
ASP A 133
ASN A  25
GLN A  26
 MG  A 901 ( 3.4A)
None
AMP  A 301 (-3.3A)
AMP  A 301 (-3.7A)
 1.17A 5l6eA-2f17A:
2.3		 5l6eA-2f17A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 316
ARG A  84
ASN A 337
GLN A 295
 None
 1.22A 5l6eA-2gskA:
undetectable		 5l6eA-2gskA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 ASP A 314
ASP A 307
ARG A 311
ASN A 313
 None
 1.22A 5l6eA-2hihA:
undetectable		 5l6eA-2hihA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 ASP A 112
ASP A 136
ASN A 159
GLN A  77
 None
None
AI2  A 501 (-3.3A)
AI2  A 501 (-2.8A)
 1.21A 5l6eA-2hj9A:
undetectable		 5l6eA-2hj9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		4 ASP A  79
ASN A  58
ASN A  75
GLN A  53
 None
 1.24A 5l6eA-2i79A:
undetectable		 5l6eA-2i79A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9d HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059

(Methanocaldococcus
jannaschii) 		PF00543
(P-II) 		4 ASP E  69
ASP E  22
ASN E  80
ASN E  72
 None
 1.16A 5l6eA-2j9dE:
undetectable		 5l6eA-2j9dE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 ASP A 469
ASN A 474
ASN A 470
GLN A  57
 None
 1.18A 5l6eA-2jf7A:
undetectable		 5l6eA-2jf7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 ASP X 421
ASN X 426
ASN X 422
GLN X  17
 None
 1.12A 5l6eA-2jfeX:
undetectable		 5l6eA-2jfeX:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kw3 DNA-BINDING PROTEIN
RFX5
REGULATORY FACTOR
X-ASSOCIATED PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
PF15289
(RFXA_RFXANK_bdg) 		5 ASP A  60
ASP C 219
ARG C 235
ASN C 232
ASN A  59
 None
 1.35A 5l6eA-2kw3A:
undetectable		 5l6eA-2kw3A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8x LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa) 		PF04390
(LptE) 		4 ASP A 147
ASP A  77
ASN A 101
GLN A 118
 None
 1.16A 5l6eA-2n8xA:
undetectable		 5l6eA-2n8xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ASP A 116
ASP A 141
ARG A 208
ASN A 184
 None
 1.27A 5l6eA-2o4vA:
undetectable		 5l6eA-2o4vA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 ASP A 239
ASP A 220
ARG A 245
ASN A 267
 None
 1.21A 5l6eA-2o5pA:
undetectable		 5l6eA-2o5pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 ASP A 193
ASP A  66
ARG A  64
ASN A  42
 None
 1.16A 5l6eA-2p4bA:
undetectable		 5l6eA-2p4bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 ASP A  28
ASN A 103
ASN A  32
GLN A  36
 None
 1.26A 5l6eA-2pbfA:
2.0		 5l6eA-2pbfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 ASP A 209
ARG A 159
ASN A 173
GLN A 163
 None
 1.06A 5l6eA-2qtyA:
undetectable		 5l6eA-2qtyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 391
ARG A 389
ASN A 409
GLN A 429
 None
 1.23A 5l6eA-2uxtA:
undetectable		 5l6eA-2uxtA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Schizosaccharomyces
pombe) 		PF13519
(VWA_2) 		4 ASP A  43
ARG A 101
ASN A  47
GLN A 106
 None
 1.30A 5l6eA-2x5nA:
2.3		 5l6eA-2x5nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ASP A 276
ARG A 203
ASN A 201
GLN A 282
 None
 1.25A 5l6eA-3ai7A:
undetectable		 5l6eA-3ai7A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ARG A 158
ASN A 147
ASN A 116
GLN A 118
 None
CA  A1200 (-3.1A)
None
None
 1.18A 5l6eA-3ak5A:
undetectable		 5l6eA-3ak5A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASP A  23
ARG A  29
ASN A  30
GLN A 378
 None
 1.15A 5l6eA-3gkqA:
undetectable		 5l6eA-3gkqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ARG A 169
ASN A 141
ASN A  91
GLN A  93
 None
 1.15A 5l6eA-3h09A:
undetectable		 5l6eA-3h09A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASP A  63
ARG A  70
ASN A  60
GLN A  59
 None
 1.29A 5l6eA-3i12A:
undetectable		 5l6eA-3i12A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 305
ASP A 258
ARG A 300
GLN A 281
 None
 1.24A 5l6eA-3i3wA:
undetectable		 5l6eA-3i3wA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		4 ASP B  76
ARG B  41
ASN B  42
ASN B  74
 None
 1.04A 5l6eA-3j7aB:
undetectable		 5l6eA-3j7aB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		4 ASP A 107
ASN A 330
ASN A 487
GLN A 490
 None
 1.20A 5l6eA-3lfvA:
undetectable		 5l6eA-3lfvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ASP A 211
ARG A  77
ASN A  79
ASN A 187
 None
 1.18A 5l6eA-3o9pA:
undetectable		 5l6eA-3o9pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 ASP A 143
ARG A 159
ASN A 139
GLN A 135
 None
 1.19A 5l6eA-3odmA:
undetectable		 5l6eA-3odmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		4 ASP A 379
ASN A 390
ASN A 382
GLN A 472
 None
 0.97A 5l6eA-3unvA:
undetectable		 5l6eA-3unvA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ASP A  69
ARG A  68
ASN A 486
GLN A 559
 None
 1.27A 5l6eA-3zuqA:
undetectable		 5l6eA-3zuqA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ASP A 716
ARG A 712
ASN A 695
GLN A 709
 None
 1.29A 5l6eA-4bsnA:
undetectable		 5l6eA-4bsnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ASP A 713
ARG A 709
ASN A 692
GLN A 706
 None
 1.23A 5l6eA-4fgvA:
undetectable		 5l6eA-4fgvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goq HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF07372
(DUF1491) 		4 ASP A  74
ASP A  42
ARG A  49
GLN A  65
 None
 1.28A 5l6eA-4goqA:
undetectable		 5l6eA-4goqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 ASP A 312
ASP A 317
ARG A 292
GLN A 272
 None
 1.30A 5l6eA-4hnnA:
1.9		 5l6eA-4hnnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF16024
(DUF4785) 		4 ASP A 371
ASP A  45
ARG A 336
GLN A 338
 None
 1.24A 5l6eA-4kh9A:
undetectable		 5l6eA-4kh9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ASP A 120
ASP A 197
ASN A 122
GLN A 159
 25L  A1000 ( 4.4A)
None
25L  A1000 (-3.3A)
None
 1.06A 5l6eA-4o1oA:
undetectable		 5l6eA-4o1oA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 ASP B 161
ASP B 213
ARG B 123
ASN B 162
 None
 1.26A 5l6eA-4pswB:
undetectable		 5l6eA-4pswB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 ASP A  29
ASP A  65
ASN A  63
ASN A 336
 None
 0.99A 5l6eA-4r7fA:
undetectable		 5l6eA-4r7fA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		5 ASP A 116
ASP A 141
ARG A 209
ASN A 185
GLN A 183
 None
 1.47A 5l6eA-4rjwA:
undetectable		 5l6eA-4rjwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 ASP B 162
ARG B 140
ASN B 137
ASN B 163
 None
 1.06A 5l6eA-4rs1B:
undetectable		 5l6eA-4rs1B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGS

(Sphingomonas
sp.) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		4 ASP C  95
ASP C 134
ARG C 140
ASN C  96
 None
 1.22A 5l6eA-4tqvC:
undetectable		 5l6eA-4tqvC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		4 ASP A  62
ASP A 270
ARG A 273
GLN A  50
 None
MG  A 301 (-3.1A)
None
None
 1.28A 5l6eA-4xxpA:
undetectable		 5l6eA-4xxpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y66 MND1
PUTATIVE TBPIP
FAMILY PROTEIN

(Giardia
intestinalis;
Giardia
intestinalis) 		PF03962
(Mnd1)
PF07106
(TBPIP) 		4 ASP B 163
ARG A 154
ASN A 155
ASN B 160
 None
 1.15A 5l6eA-4y66B:
undetectable		 5l6eA-4y66B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 ASP A 149
ASP A 118
ARG A 174
GLN A 171
 None
 1.24A 5l6eA-4zr1A:
undetectable		 5l6eA-4zr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ASP A 648
ASP A 400
ARG A 432
GLN A 395
 None
None
None
ADP  A1103 (-3.4A)
 1.17A 5l6eA-5b7iA:
undetectable		 5l6eA-5b7iA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 ASP A 110
ARG A 170
ASN A 237
ASN A 171
 None
 1.13A 5l6eA-5fkrA:
undetectable		 5l6eA-5fkrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g26 INTIMIN

(Escherichia
coli) 		PF11924
(IAT_beta) 		4 ASP A 229
ASP A 390
ASN A 378
GLN A 439
 None
 1.27A 5l6eA-5g26A:
undetectable		 5l6eA-5g26A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ASP A 589
ASN A 484
ASN A 473
GLN A 477
 None
 1.12A 5l6eA-5h53A:
undetectable		 5l6eA-5h53A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 ASP A 263
ASP A 160
ARG A 181
ASN A 185
 None
None
MPD  A 504 ( 4.9A)
MPD  A 504 (-3.4A)
 1.01A 5l6eA-5hucA:
undetectable		 5l6eA-5hucA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP A 377
ASP A 395
ARG A 536
ASN A 539
ASN A 549
GLN A 550
 None
 0.73A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ASP A 625
ASP A 607
ASN A 635
GLN A 530
 None
 1.17A 5l6eA-5iv8A:
undetectable		 5l6eA-5iv8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		4 ASP A 602
ASP A 584
ASN A 612
GLN A 507
 None
 1.21A 5l6eA-5iv9A:
undetectable		 5l6eA-5iv9A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TRANSCRIPTION
ELONGATION FACTOR A
PROTEIN 1

(Homo sapiens) 		PF01096
(TFIIS_C)
PF07500
(TFIIS_M) 		4 ASP U 200
ARG U 190
ASN U 189
ASN U 197
 None
 0.97A 5l6eA-5iy6U:
undetectable		 5l6eA-5iy6U:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		4 ASP A 532
ASP A 597
ASN A 620
ASN A 533
 None
 1.27A 5l6eA-5j8jA:
undetectable		 5l6eA-5j8jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 ASP A 344
ARG A 581
ASN A  69
GLN A 351
 None
None
EDO  A1012 (-3.3A)
None
 1.14A 5l6eA-5jjrA:
undetectable		 5l6eA-5jjrA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ASP A 297
ARG A 337
ASN A 333
ASN A 296
 None
 1.01A 5l6eA-5jwfA:
undetectable		 5l6eA-5jwfA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 ASP C 175
ASP C 187
ARG C 217
ASN C 221
 None
 0.89A 5l6eA-5ks8C:
undetectable		 5l6eA-5ks8C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 ARG A  99
ASN A 169
ASN A 225
GLN A 227
 None
 1.12A 5l6eA-5ly8A:
undetectable		 5l6eA-5ly8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 ASP A  73
ASP A  45
ASN A  15
ASN A 283
 None
None
None
CL  A 402 (-4.2A)
 1.17A 5l6eA-5m28A:
undetectable		 5l6eA-5m28A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 ASP B 100
ASN B 111
ASN B 103
GLN B 106
 None
EDO  B 615 (-3.2A)
None
None
 1.16A 5l6eA-5m99B:
undetectable		 5l6eA-5m99B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mau CHLORITE DISMUTASE

(Cyanothece sp.
PCC 7425) 		no annotation 4 ASP A 140
ARG A   4
ASN A   3
GLN A  53
 None
SO4  A 202 (-3.4A)
None
None
 1.12A 5l6eA-5mauA:
undetectable		 5l6eA-5mauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr5 MATA PROTEIN

(Dictyostelium
discoideum) 		no annotation 4 ARG A  83
ASN A  79
ASN A  54
GLN A  53
 None
 1.20A 5l6eA-5nr5A:
undetectable		 5l6eA-5nr5A:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP A 377
ASP A 395
ARG A 536
ASN A 539
ASN A 549
GLN A 550
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-3.7A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.7A)
 0.14A 5l6eA-5teyA:
36.0		 5l6eA-5teyA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF17289
(Terminase_6C) 		4 ASP A 310
ASP A 445
ASN A 383
GLN A 440
 None
 1.15A 5l6eA-5tgeA:
undetectable		 5l6eA-5tgeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 ASP A 461
ASP A 502
ARG A 500
ASN A 460
 None
 1.07A 5l6eA-5u1sA:
2.2		 5l6eA-5u1sA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04084
(ORC2) 		4 ASP B 428
ARG B 323
ASN B 324
ASN B 426
 None
 1.16A 5l6eA-5v8fB:
undetectable		 5l6eA-5v8fB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens;
Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
PF13927
(Ig_3) 		4 ASP A 455
ARG A 310
ASN A 420
GLN C  76
 None
NAG  A 702 (-4.0A)
NAG  A 701 (-1.8A)
None
 1.29A 5l6eA-5vxzA:
undetectable		 5l6eA-5vxzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wte VP3

(Hepatovirus A) 		PF00073
(Rhv) 		4 ASP C 178
ASP C  82
ARG C 185
ASN C 184
 None
 1.24A 5l6eA-5wteC:
undetectable		 5l6eA-5wteC:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 ASP Z  71
ASP Z  87
ASN Z  93
GLN Z  66
 None
 1.14A 5l6eA-5wtiZ:
undetectable		 5l6eA-5wtiZ:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		4 ASP w 119
ARG w 130
ASN w 111
ASN w 127
 None
 1.24A 5l6eA-5xtdw:
undetectable		 5l6eA-5xtdw:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 ASP A1194
ASP A1186
ASN A1196
GLN A1165
 CA  A1705 (-2.2A)
None
None
None
 1.23A 5l6eA-5xyaA:
undetectable		 5l6eA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84

(Saccharomyces
cerevisiae) 		no annotation 4 ASP H 642
ASP H 696
ASN H 638
GLN H 634
 None
 1.03A 5l6eA-5yfpH:
undetectable		 5l6eA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 ASP A 103
ASN A 109
ASN A 142
GLN A 888
 None
 1.02A 5l6eA-6cv9A:
undetectable		 5l6eA-6cv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 ASP A 307
ARG A 154
ASN A 150
ASN A  26
 None
 1.30A 5l6eA-6d5iA:
undetectable		 5l6eA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 ASP A 512
ASN A 560
ASN A 563
GLN A 566
 C  V   9 ( 4.4A)
U  V   3 ( 4.2A)
None
A  V   4 ( 2.8A)
 0.99A 5l6eA-6f5oA:
undetectable		 5l6eA-6f5oA:
undetectable