SIMILAR PATTERNS OF AMINO ACIDS FOR 5L5F_Y_BO2Y301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aos | ARGININOSUCCINATELYASE (Homo sapiens) |
PF00206(Lyase_1)PF14698(ASL_C2) | 4 | SER A 234ALA A 203ASP A 115SER A 112 | None | 1.06A | 5l5fY-1aosA:0.05l5fZ-1aosA:undetectable | 5l5fY-1aosA:18.325l5fZ-1aosA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1du5 | ZEAMATIN (Zea mays) |
PF00314(Thaumatin) | 4 | THR A 81ALA A 180ASP A 186SER A 190 | None | 1.13A | 5l5fY-1du5A:undetectable5l5fZ-1du5A:0.0 | 5l5fY-1du5A:20.945l5fZ-1du5A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5m | BETA KETOACYL ACYLCARRIER PROTEINSYNTHASE II (Synechocystissp. PCC 6803) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | THR A 342SER A 337SER A 336ALA A 356 | None | 0.96A | 5l5fY-1e5mA:0.05l5fZ-1e5mA:0.0 | 5l5fY-1e5mA:19.315l5fZ-1e5mA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | SER A1434ALA A1429ASP A1363SER A1397 | None | 1.10A | 5l5fY-1e6yA:0.05l5fZ-1e6yA:0.0 | 5l5fY-1e6yA:18.525l5fZ-1e6yA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lkd | BIPHENYL-2,3-DIOL1,2-DIOXYGENASE (Paraburkholderiaxenovorans) |
PF00903(Glyoxalase) | 4 | SER A 287SER A 236MET A 175SER A 281 | NoneP6G A 600 ( 4.0A)P6G A 600 (-4.4A)BP6 A 300 ( 4.3A) | 1.12A | 5l5fY-1lkdA:0.05l5fZ-1lkdA:undetectable | 5l5fY-1lkdA:22.015l5fZ-1lkdA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llp | LIGNIN PEROXIDASE (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | SER A 53ALA A 139ASP A 68SER A 70 | NoneNone CA A 351 (-3.1A) CA A 351 (-2.4A) | 1.12A | 5l5fY-1llpA:0.05l5fZ-1llpA:0.0 | 5l5fY-1llpA:17.445l5fZ-1llpA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzk | HEROIN ESTERASE (Rhodococcus sp.) |
PF07859(Abhydrolase_3) | 4 | THR A 6SER A 284ASP A 264SER A 199 | None | 0.95A | 5l5fY-1lzkA:0.05l5fZ-1lzkA:0.0 | 5l5fY-1lzkA:22.265l5fZ-1lzkA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mox | EPIDERMAL GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain) | 4 | THR A 278SER A 291ALA A 286SER A 342 | None | 1.06A | 5l5fY-1moxA:undetectable5l5fZ-1moxA:undetectable | 5l5fY-1moxA:17.665l5fZ-1moxA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 4 | THR A 81ALA A 178ASP A 184SER A 188 | None | 1.06A | 5l5fY-1pcvA:undetectable5l5fZ-1pcvA:0.0 | 5l5fY-1pcvA:22.045l5fZ-1pcvA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 4 | THR A 513ALA A 506ASP A 214SER A 210 | NoneNone175 A 211 ( 4.2A)175 A 211 ( 4.7A) | 1.10A | 5l5fY-1t6pA:undetectable5l5fZ-1t6pA:undetectable | 5l5fY-1t6pA:14.895l5fZ-1t6pA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t9f | PROTEIN 1D10 (Caenorhabditiselegans) |
PF02815(MIR) | 4 | SER A 163ALA A 61ASP A 39SER A 41 | None | 1.12A | 5l5fY-1t9fA:undetectable5l5fZ-1t9fA:undetectable | 5l5fY-1t9fA:20.785l5fZ-1t9fA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 4 | SER A 14SER A 417ASP A 64SER A 57 | None | 1.13A | 5l5fY-1wcgA:0.05l5fZ-1wcgA:undetectable | 5l5fY-1wcgA:18.615l5fZ-1wcgA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlp | NEUTROPHIL CYTOSOLFACTOR 1 (Homo sapiens) |
PF00018(SH3_1) | 4 | SER B 191SER B 277ALA B 207SER B 208 | None | 1.04A | 5l5fY-1wlpB:undetectable5l5fZ-1wlpB:undetectable | 5l5fY-1wlpB:22.565l5fZ-1wlpB:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yln | HYPOTHETICAL PROTEINVCA0042 (Vibrio cholerae) |
PF07238(PilZ)PF12945(YcgR_2) | 4 | THR A 58SER A 109MET A 73ALA A 122 | None | 1.01A | 5l5fY-1ylnA:undetectable5l5fZ-1ylnA:undetectable | 5l5fY-1ylnA:23.195l5fZ-1ylnA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzp | PEROXIDASEMANGANESE-DEPENDENTI (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | SER A 52ALA A 136ASP A 64SER A 66 | NoneNone CA A 372 (-3.1A) CA A 372 (-2.4A) | 1.08A | 5l5fY-1yzpA:undetectable5l5fZ-1yzpA:undetectable | 5l5fY-1yzpA:19.615l5fZ-1yzpA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztm | FUSION GLYCOPROTEIN (Humanrespirovirus 3) |
PF00523(Fusion_gly) | 4 | THR A 390SER A 300ALA A 377ASP A 297 | None | 1.13A | 5l5fY-1ztmA:undetectable5l5fZ-1ztmA:undetectable | 5l5fY-1ztmA:15.655l5fZ-1ztmA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aex | COPROPORPHYRINOGENIII OXIDASE,MITOCHONDRIAL (Homo sapiens) |
PF01218(Coprogen_oxidas) | 4 | THR A 409MET A 222ALA A 218SER A 215 | None | 1.11A | 5l5fY-2aexA:undetectable5l5fZ-2aexA:0.0 | 5l5fY-2aexA:19.885l5fZ-2aexA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2axq | SACCHAROPINEDEHYDROGENASE (Saccharomycescerevisiae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 4 | SER A 172ALA A 392ASP A 355SER A 389 | None | 1.06A | 5l5fY-2axqA:undetectable5l5fZ-2axqA:undetectable | 5l5fY-2axqA:18.435l5fZ-2axqA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b81 | LUCIFERASE-LIKEMONOOXYGENASE (Bacillus cereus) |
PF00296(Bac_luciferase) | 4 | THR A 197SER A 133SER A 105ASP A 139 | NoneSO4 A2429 ( 4.7A)NoneNone | 0.88A | 5l5fY-2b81A:undetectable5l5fZ-2b81A:undetectable | 5l5fY-2b81A:21.325l5fZ-2b81A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2be1 | SERINE/THREONINE-PROTEINKINASE/ENDORIBONUCLEASE IRE1 (Saccharomycescerevisiae) |
no annotation | 4 | THR A 165ALA A 295ASP A 221SER A 291 | None | 0.94A | 5l5fY-2be1A:undetectable5l5fZ-2be1A:undetectable | 5l5fY-2be1A:21.965l5fZ-2be1A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw6 | HYDROXYMETHYLGLUTARYL-COA LYASE,MITOCHONDRIAL (Homo sapiens) |
PF00682(HMGL-like) | 4 | SER A 142SER A 146LYS A 184SER A 169 | None | 1.05A | 5l5fY-2cw6A:undetectable5l5fZ-2cw6A:undetectable | 5l5fY-2cw6A:21.045l5fZ-2cw6A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fhg | PROTEASOME, BETASUBUNIT (Mycobacteriumtuberculosis) |
no annotation | 4 | THR H 301SER H 327LYS H 333ALA H 349 | None | 0.42A | 5l5fY-2fhgH:25.65l5fZ-2fhgH:22.0 | 5l5fY-2fhgH:26.675l5fZ-2fhgH:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g1s | RENIN (Homo sapiens) |
PF00026(Asp) | 4 | THR A 34SER A 79ALA A 309SER A 228 | None4IG A 885 (-3.0A)NoneNone | 1.11A | 5l5fY-2g1sA:undetectable5l5fZ-2g1sA:undetectable | 5l5fY-2g1sA:22.045l5fZ-2g1sA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g76 | D-3-PHOSPHOGLYCERATEDEHYDROGENASE (Homo sapiens) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | THR A 97SER A 54ALA A 285SER A 286 | NoneMLT A 503 (-2.7A)MLT A 503 ( 3.3A)None | 1.08A | 5l5fY-2g76A:undetectable5l5fZ-2g76A:undetectable | 5l5fY-2g76A:23.665l5fZ-2g76A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh4 | PUTATIVE GLYCOSYLHYDROLASE YTER (Bacillussubtilis) |
PF07470(Glyco_hydro_88) | 4 | THR A 316SER A 277SER A 280ASP A 255 | None | 1.00A | 5l5fY-2gh4A:undetectable5l5fZ-2gh4A:undetectable | 5l5fY-2gh4A:21.215l5fZ-2gh4A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyf | NOSTOC PUNCTIFORMEPHENYLALANINEAMMONIA LYASE (Nostocpunctiforme) |
PF00221(Lyase_aromatic) | 4 | THR A 178SER A 226ALA A 220SER A 137 | None | 1.12A | 5l5fY-2nyfA:undetectable5l5fZ-2nyfA:undetectable | 5l5fY-2nyfA:16.025l5fZ-2nyfA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 4 | SER A 301SER A 22ALA A 314ASP A 318 | None | 1.11A | 5l5fY-2o3iA:undetectable5l5fZ-2o3iA:undetectable | 5l5fY-2o3iA:20.925l5fZ-2o3iA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2poz | PUTATIVE DEHYDRATASE (Mesorhizobiumjaponicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | THR A 261SER A 94ALA A 82SER A 79 | None | 0.85A | 5l5fY-2pozA:undetectable5l5fZ-2pozA:undetectable | 5l5fY-2pozA:20.225l5fZ-2pozA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwi | ALPHA-/BETA-GALACTOSIDEALPHA-2,3-SIALYLTRANSFERASE (Photobacteriumphosphoreum) |
PF11477(PM0188) | 4 | SER A 180SER A 181ASP A 189SER A 191 | None | 1.13A | 5l5fY-2zwiA:undetectable5l5fZ-2zwiA:undetectable | 5l5fY-2zwiA:19.955l5fZ-2zwiA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b40 | PROBABLE DIPEPTIDASE (Pseudomonasaeruginosa) |
PF01244(Peptidase_M19) | 4 | THR A 61SER A 389SER A 388SER A 243 | None | 1.10A | 5l5fY-3b40A:undetectable5l5fZ-3b40A:undetectable | 5l5fY-3b40A:19.225l5fZ-3b40A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebb | PHOSPHOLIPASEA2-ACTIVATINGPROTEIN (Homo sapiens) |
PF08324(PUL) | 4 | THR A 731SER A 692SER A 694ALA A 687 | None | 1.11A | 5l5fY-3ebbA:undetectable5l5fZ-3ebbA:undetectable | 5l5fY-3ebbA:21.645l5fZ-3ebbA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5c | NUCLEAR RECEPTORSUBFAMILY 0 GROUP BMEMBER 1 (Mus musculus) |
PF00104(Hormone_recep) | 4 | THR B 267MET B 298ALA B 294SER B 443 | None | 1.07A | 5l5fY-3f5cB:undetectable5l5fZ-3f5cB:undetectable | 5l5fY-3f5cB:20.715l5fZ-3f5cB:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gpr | RHODOCETIN SUBUNITGAMMA (Calloselasmarhodostoma) |
PF00059(Lectin_C) | 4 | THR C3098SER C3101ASP C3074SER C3082 | None | 1.01A | 5l5fY-3gprC:undetectable5l5fZ-3gprC:undetectable | 5l5fY-3gprC:17.145l5fZ-3gprC:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvd | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 4 | THR A 488SER A 230SER A 227ALA A 258 | None | 1.05A | 5l5fY-3hvdA:undetectable5l5fZ-3hvdA:undetectable | 5l5fY-3hvdA:16.765l5fZ-3hvdA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igh | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcushorikoshii) |
PF07969(Amidohydro_3) | 4 | SER X 82SER X 222ALA X 328ASP X 326 | None | 1.11A | 5l5fY-3ighX:undetectable5l5fZ-3ighX:undetectable | 5l5fY-3ighX:18.815l5fZ-3ighX:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrh | ANTI-HUNTINGTIN VLDOMAIN (Homo sapiens) |
PF07686(V-set) | 4 | THR A 19SER A 64ALA A 72ASP A 52 | None | 1.09A | 5l5fY-3lrhA:undetectable5l5fZ-3lrhA:undetectable | 5l5fY-3lrhA:20.745l5fZ-3lrhA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mj8 | STIMULATORY HAMSTERANTIBODY HL4E10 FABLIGHT CHAIN (Cricetulusmigratorius) |
no annotation | 4 | THR L 20SER L 63ALA L 71ASP L 51 | None | 1.10A | 5l5fY-3mj8L:undetectable5l5fZ-3mj8L:undetectable | 5l5fY-3mj8L:21.695l5fZ-3mj8L:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2z | LYSOSOMAL PRO-XCARBOXYPEPTIDASE (Homo sapiens) |
PF05577(Peptidase_S28) | 4 | THR B 90ALA B 202ASP B 458SER B 425 | None | 1.12A | 5l5fY-3n2zB:undetectable5l5fZ-3n2zB:undetectable | 5l5fY-3n2zB:18.595l5fZ-3n2zB:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ncy | ADIC (Salmonellaenterica) |
PF13520(AA_permease_2) | 4 | THR A 89ALA A 75ASP A 67SER A 69 | None | 1.09A | 5l5fY-3ncyA:undetectable5l5fZ-3ncyA:undetectable | 5l5fY-3ncyA:17.505l5fZ-3ncyA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 4 | SER A 351MET A 152ASP A 354SER A 145 | None | 1.13A | 5l5fY-3nz4A:undetectable5l5fZ-3nz4A:undetectable | 5l5fY-3nz4A:14.565l5fZ-3nz4A:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3out | GLUTAMATE RACEMASE (Francisellatularensis) |
PF01177(Asp_Glu_race) | 4 | THR A 18SER A 209ASP A 96SER A 78 | None | 1.11A | 5l5fY-3outA:undetectable5l5fZ-3outA:undetectable | 5l5fY-3outA:21.055l5fZ-3outA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 4 | THR N 244SER N 302SER N 301ALA N 340 | None | 1.13A | 5l5fY-3rkoN:undetectable5l5fZ-3rkoN:undetectable | 5l5fY-3rkoN:19.385l5fZ-3rkoN:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6b | METHIONINEAMINOPEPTIDASE (Plasmodiumfalciparum) |
PF00557(Peptidase_M24) | 4 | THR A 336SER A 195SER A 155ALA A 115 | None | 1.10A | 5l5fY-3s6bA:undetectable5l5fZ-3s6bA:undetectable | 5l5fY-3s6bA:20.225l5fZ-3s6bA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tex | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF07691(PA14)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 4 | THR A 488SER A 230SER A 227ALA A 258 | None | 1.08A | 5l5fY-3texA:undetectable5l5fZ-3texA:undetectable | 5l5fY-3texA:13.725l5fZ-3texA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 1 (Bos taurus) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF08282(Hydrolase_3)PF13246(Cation_ATPase) | 4 | THR A 804SER A 935SER A 939ALA A 100 | None | 1.11A | 5l5fY-3tlmA:undetectable5l5fZ-3tlmA:undetectable | 5l5fY-3tlmA:12.655l5fZ-3tlmA:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bct | THAUMATIN-LIKEPROTEIN (Actinidiadeliciosa) |
PF00314(Thaumatin) | 4 | THR A 104ALA A 199ASP A 205SER A 209 | None | 1.10A | 5l5fY-4bctA:undetectable5l5fZ-4bctA:undetectable | 5l5fY-4bctA:18.585l5fZ-4bctA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj8 | ZEBAVIDIN (Danio rerio) |
PF01382(Avidin) | 4 | THR A 40SER A 100SER A 111ASP A 103 | NoneBTN A1123 ( 4.8A)NoneNone | 1.02A | 5l5fY-4bj8A:undetectable5l5fZ-4bj8A:undetectable | 5l5fY-4bj8A:24.415l5fZ-4bj8A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ct4 | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF16415(CNOT1_CAF1_bind) | 4 | SER A1145LYS A1203ALA A1200SER A1240 | None | 0.96A | 5l5fY-4ct4A:undetectable5l5fZ-4ct4A:undetectable | 5l5fY-4ct4A:19.695l5fZ-4ct4A:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cv5 | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF12842(DUF3819) | 4 | THR A1210SER A1112SER A1111ALA A1204 | None | 1.05A | 5l5fY-4cv5A:undetectable5l5fZ-4cv5A:undetectable | 5l5fY-4cv5A:21.835l5fZ-4cv5A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e21 | 6-PHOSPHOGLUCONATEDEHYDROGENASE(DECARBOXYLATING) (Geobactermetallireducens) |
PF00393(6PGD)PF03446(NAD_binding_2) | 4 | SER A 74ALA A 69ASP A 91SER A 95 | None | 1.02A | 5l5fY-4e21A:undetectable5l5fZ-4e21A:undetectable | 5l5fY-4e21A:21.245l5fZ-4e21A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exl | PHOSPHATE-BINDINGPROTEIN PSTS 1 (Streptococcuspneumoniae) |
PF12849(PBP_like_2) | 4 | THR A 203SER A 233ALA A 40SER A 38 | None CL A 305 (-4.9A)NoneNone | 1.08A | 5l5fY-4exlA:undetectable5l5fZ-4exlA:undetectable | 5l5fY-4exlA:23.445l5fZ-4exlA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4f | THREONINE SYNTHASE (Brucellamelitensis) |
PF00291(PALP)PF14821(Thr_synth_N) | 4 | SER A 217ALA A 463ASP A 159SER A 461 | None | 1.05A | 5l5fY-4f4fA:undetectable5l5fZ-4f4fA:undetectable | 5l5fY-4f4fA:17.215l5fZ-4f4fA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbl | LIPS LIPOLYTICENZYME (unidentified) |
PF12146(Hydrolase_4) | 4 | SER A 255SER A 224MET A 65SER A 126 | NoneNoneNoneSPD A 301 ( 2.3A) | 1.02A | 5l5fY-4fblA:undetectable5l5fZ-4fblA:undetectable | 5l5fY-4fblA:21.205l5fZ-4fblA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvf | BETA-HEXOSAMINIDASE (Salmonellaenterica) |
PF00933(Glyco_hydro_3) | 4 | THR A 179SER A 127ALA A 212ASP A 122 | None | 1.13A | 5l5fY-4gvfA:undetectable5l5fZ-4gvfA:undetectable | 5l5fY-4gvfA:21.515l5fZ-4gvfA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jru | THAUMATIN-LIKEPROTEIN (Vitis vinifera) |
PF00314(Thaumatin) | 4 | THR A 104ALA A 199ASP A 205SER A 209 | None | 1.12A | 5l5fY-4jruA:undetectable5l5fZ-4jruA:undetectable | 5l5fY-4jruA:20.855l5fZ-4jruA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 4 | SER A 118ALA A 159ASP A 121SER A 157 | None | 1.11A | 5l5fY-4kpgA:undetectable5l5fZ-4kpgA:undetectable | 5l5fY-4kpgA:20.725l5fZ-4kpgA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l5h | VVTL1 (Vitis vinifera) |
PF00314(Thaumatin) | 4 | THR A 104ALA A 196ASP A 202SER A 206 | None | 1.07A | 5l5fY-4l5hA:undetectable5l5fZ-4l5hA:undetectable | 5l5fY-4l5hA:21.655l5fZ-4l5hA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l63 | ECXA (Escherichiacoli) |
PF16313(DUF4953) | 4 | SER A 216SER A 246ALA A 206SER A 270 | None | 0.88A | 5l5fY-4l63A:undetectable5l5fZ-4l63A:undetectable | 5l5fY-4l63A:20.935l5fZ-4l63A:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nik | SINGLE-CHAIN FVFRAGMENT ANTIBODY (Homo sapiens) |
PF07686(V-set) | 4 | THR B 153SER B 199ALA B 207ASP B 187 | None | 0.97A | 5l5fY-4nikB:undetectable5l5fZ-4nikB:undetectable | 5l5fY-4nikB:20.555l5fZ-4nikB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ql6 | CARBOXY-TERMINALPROCESSING PROTEASE (Chlamydiatrachomatis) |
PF00595(PDZ)PF03572(Peptidase_S41) | 4 | THR A 359SER A 453ASP A 475SER A 527 | None | 1.10A | 5l5fY-4ql6A:undetectable5l5fZ-4ql6A:undetectable | 5l5fY-4ql6A:17.145l5fZ-4ql6A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r3u | 2-HYDROXYISOBUTYRYL-COA MUTASE LARGESUBUNIT (Aquincolatertiaricarbonis) |
PF01642(MM_CoA_mutase) | 4 | THR A 99ALA A 143ASP A 145SER A 128 | None | 1.04A | 5l5fY-4r3uA:undetectable5l5fZ-4r3uA:undetectable | 5l5fY-4r3uA:15.255l5fZ-4r3uA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 4 | SER A 319SER A 321ALA A 311SER A 289 | None | 1.04A | 5l5fY-4sliA:undetectable5l5fZ-4sliA:undetectable | 5l5fY-4sliA:16.335l5fZ-4sliA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u6u | COG5 (Kluyveromyceslactis) |
PF10392(COG5) | 4 | SER B 253SER B 252ALA B 259SER B 328 | None | 1.10A | 5l5fY-4u6uB:undetectable5l5fZ-4u6uB:undetectable | 5l5fY-4u6uB:25.005l5fZ-4u6uB:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upi | SULFATASE FAMILYPROTEIN (Ruegeriapomeroyi) |
PF00884(Sulfatase) | 4 | SER A 411SER A 410ALA A 372SER A 370 | None | 1.10A | 5l5fY-4upiA:undetectable5l5fZ-4upiA:undetectable | 5l5fY-4upiA:16.875l5fZ-4upiA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y5x | DIABODY 310 VHDOMAIN (Homo sapiens) |
PF07686(V-set) | 4 | THR B 19SER B 64ALA B 72ASP B 52 | None | 1.08A | 5l5fY-4y5xB:undetectable5l5fZ-4y5xB:undetectable | 5l5fY-4y5xB:19.635l5fZ-4y5xB:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ye5 | PEPTIDOGLYCANSYNTHETASEPENICILLIN-BINDINGPROTEIN 3 (Bifidobacteriumadolescentis) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | THR A 554MET A 443ALA A 312SER A 310 | None | 1.01A | 5l5fY-4ye5A:undetectable5l5fZ-4ye5A:undetectable | 5l5fY-4ye5A:17.155l5fZ-4ye5A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpj | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Sphaerobacterthermophilus) |
PF13458(Peripla_BP_6) | 4 | THR A 173SER A 198ALA A 159SER A 156 | None | 1.06A | 5l5fY-4zpjA:undetectable5l5fZ-4zpjA:undetectable | 5l5fY-4zpjA:18.425l5fZ-4zpjA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2e | BETA-LACTAMASE (Yersiniaenterocolitica) |
PF13354(Beta-lactamase2) | 4 | THR A 220SER A 256ALA A 18SER A 17 | None | 1.04A | 5l5fY-5e2eA:undetectable5l5fZ-5e2eA:undetectable | 5l5fY-5e2eA:23.055l5fZ-5e2eA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6k | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | SER A 169SER A 409LYS A 309SER A 337 | None | 1.10A | 5l5fY-5e6kA:undetectable5l5fZ-5e6kA:undetectable | 5l5fY-5e6kA:16.375l5fZ-5e6kA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ed1 | DOUBLE-STRANDEDRNA-SPECIFIC EDITASE1 (Homo sapiens) |
PF02137(A_deamin) | 4 | THR A 373SER A 399SER A 402SER A 625 | None | 1.12A | 5l5fY-5ed1A:undetectable5l5fZ-5ed1A:undetectable | 5l5fY-5ed1A:19.455l5fZ-5ed1A:20.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 4 | THR L 1SER L 21MET L 45ALA L 49 | None | 0.76A | 5l5fY-5fmgL:28.45l5fZ-5fmgL:23.7 | 5l5fY-5fmgL:48.585l5fZ-5fmgL:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fql | IDURONATE-2-SULFATASE (Homo sapiens) |
PF00884(Sulfatase) | 4 | THR A 355SER A 87SER A 90ASP A 98 | NoneALS A 84 ( 4.6A)NoneNone | 1.07A | 5l5fY-5fqlA:0.05l5fZ-5fqlA:0.0 | 5l5fY-5fqlA:17.995l5fZ-5fqlA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2v | IMPORTIN SUBUNITBETA-3 (Saccharomycescerevisiae) |
PF13513(HEAT_EZ) | 4 | THR A 995SER A 955ALA A 967SER A 921 | None | 1.01A | 5l5fY-5h2vA:undetectable5l5fZ-5h2vA:undetectable | 5l5fY-5h2vA:11.185l5fZ-5h2vA:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h64 | SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08771(FRB_dom)PF11865(DUF3385) | 4 | THR A1780SER A1893ALA A1794ASP A1902 | None | 1.13A | 5l5fY-5h64A:undetectable5l5fZ-5h64A:undetectable | 5l5fY-5h64A:6.185l5fZ-5h64A:6.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz2 | MAJOR AMPULLATESPIDROIN 1A (Nephilaclavipes) |
no annotation | 4 | THR B 94SER B 89ALA B 128SER B 131 | None | 0.99A | 5l5fY-5iz2B:undetectable5l5fZ-5iz2B:undetectable | 5l5fY-5iz2B:21.335l5fZ-5iz2B:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6o | PUTATIVE POLYKETIDESYNTHASE (Brevibacillusbrevis) |
PF14765(PS-DH) | 4 | SER A1947SER A1948ALA A1980SER A1979 | None | 0.95A | 5l5fY-5j6oA:undetectable5l5fZ-5j6oA:undetectable | 5l5fY-5j6oA:21.255l5fZ-5j6oA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jh1 | ALDOSE REDUCTASE,AKR4C7 (Zea mays) |
PF00248(Aldo_ket_red) | 4 | SER A 154ALA A 46ASP A 44SER A 20 | None | 1.11A | 5l5fY-5jh1A:undetectable5l5fZ-5jh1A:undetectable | 5l5fY-5jh1A:24.365l5fZ-5jh1A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldy | IG DOMAIN PROTEINGROUP 1 DOMAINPROTEIN (Yersiniapseudotuberculosis) |
PF09134(Invasin_D3) | 4 | SER A1717SER A1687ALA A1651SER A1664 | None | 1.05A | 5l5fY-5ldyA:undetectable5l5fZ-5ldyA:undetectable | 5l5fY-5ldyA:20.055l5fZ-5ldyA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnk | MITOCHONDRIALCOMPLEX I, ND5SUBUNIT (Ovis aries) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N)PF06455(NADH5_C) | 4 | THR L 370SER L 345SER L 349ALA L 365 | None | 1.03A | 5l5fY-5lnkL:undetectable5l5fZ-5lnkL:undetectable | 5l5fY-5lnkL:15.275l5fZ-5lnkL:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loa | MESO-DIAMINOPIMELATED-DEHYDROGENASE (Corynebacteriumglutamicum) |
PF16654(DAPDH_C) | 4 | THR A 117ALA A 275ASP A 272SER A 17 | None | 1.12A | 5l5fY-5loaA:undetectable5l5fZ-5loaA:undetectable | 5l5fY-5loaA:19.635l5fZ-5loaA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltm | PHENYLALANINEAMMONIA LYASE (Anabaena) |
no annotation | 4 | THR B 178SER B 226ALA B 220SER B 137 | None | 1.12A | 5l5fY-5ltmB:undetectable5l5fZ-5ltmB:undetectable | 5l5fY-5ltmB:17.445l5fZ-5ltmB:19.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5m2b | PROTEASOME SUBUNITBETATYPE-8,PROTEASOMESUBUNIT BETA TYPE-5 (Homo sapiens;Saccharomycescerevisiae) |
PF00227(Proteasome) | 6 | THR K 1SER K 21SER K 27LYS K 33MET K 45ALA K 49 | 7DX K 301 (-3.3A)None7DX K 301 ( 4.2A)7DX K 301 (-4.2A)7DX K 301 ( 3.8A)7DX K 301 (-3.2A) | 0.20A | 5l5fY-5m2bK:40.05l5fZ-5m2bK:23.9 | 5l5fY-5m2bK:100.005l5fZ-5m2bK:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6c | D-3-PHOSPHOGLYCERATEDEHYDROGENASE (Homo sapiens) |
no annotation | 4 | THR A 98SER A 55ALA A 286SER A 287 | NoneTLA A 401 (-2.9A)TLA A 401 ( 3.2A)None | 1.09A | 5l5fY-5n6cA:undetectable5l5fZ-5n6cA:undetectable | 5l5fY-5n6cA:15.465l5fZ-5n6cA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocy | ACPA E4 FAB FRAGMENT- LIGHT CHAIN (Homo sapiens) |
no annotation | 4 | THR L 19SER L 64ALA L 72ASP L 52 | None | 1.08A | 5l5fY-5ocyL:undetectable5l5fZ-5ocyL:undetectable | 5l5fY-5ocyL:15.825l5fZ-5ocyL:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot0 | L-ASPARAGINASE (Thermococcuskodakarensis) |
no annotation | 4 | THR A 82SER A 14ALA A 122SER A 120 | None | 1.08A | 5l5fY-5ot0A:undetectable5l5fZ-5ot0A:undetectable | 5l5fY-5ot0A:22.425l5fZ-5ot0A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5to3 | PROTHROMBIN,THROMBOMODULIN (Homo sapiens) |
PF00089(Trypsin)PF09064(Tme5_EGF_like) | 4 | THR B 192ALA B 242ASP B 114SER B 241 | None0G6 B 501 (-3.4A)NoneNone | 0.95A | 5l5fY-5to3B:undetectable5l5fZ-5to3B:undetectable | 5l5fY-5to3B:18.585l5fZ-5to3B:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uam | ULVAN LYASE-PL25 (Pseudoalteromonassp. PLSV) |
PF15892(BNR_4) | 4 | SER A 385ALA A 344ASP A 388SER A 332 | None | 1.12A | 5l5fY-5uamA:undetectable5l5fZ-5uamA:undetectable | 5l5fY-5uamA:18.015l5fZ-5uamA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqr | 2-METHYLCITRATESYNTHASE,MITOCHONDRIAL (Aspergillusfumigatus) |
no annotation | 4 | SER A 292ALA A 183ASP A 202SER A 180 | None | 0.80A | 5l5fY-5uqrA:undetectable5l5fZ-5uqrA:undetectable | 5l5fY-5uqrA:16.675l5fZ-5uqrA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xa5 | ALPHA-CATENIN-LIKEPROTEIN HMP-1BETA-CATENIN-LIKEPROTEIN HMP-2 (Caenorhabditiselegans) |
PF01044(Vinculin)no annotation | 4 | THR B 56SER B 47ASP A 192SER A 18 | None | 0.88A | 5l5fY-5xa5B:undetectable5l5fZ-5xa5B:undetectable | 5l5fY-5xa5B:12.825l5fZ-5xa5B:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xni | MCYF (Microcystisaeruginosa) |
no annotation | 4 | THR A 196SER A 107MET A 14ALA A 90 | DGL A 301 (-3.2A)NoneNoneNone | 1.05A | 5l5fY-5xniA:undetectable5l5fZ-5xniA:undetectable | 5l5fY-5xniA:14.765l5fZ-5xniA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNIT (Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | THR A 810SER A 784ASP A 792SER A 794 | None | 1.09A | 5l5fY-5xogA:undetectable5l5fZ-5xogA:undetectable | 5l5fY-5xogA:9.755l5fZ-5xogA:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0q | UPF0348 PROTEINB4417_3650 (Bacillussubtilis) |
no annotation | 4 | SER A 240MET A 58ALA A 54SER A 51 | None | 0.98A | 5l5fY-5y0qA:undetectable5l5fZ-5y0qA:undetectable | 5l5fY-5y0qA:undetectable5l5fZ-5y0qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6avo | PROTEASOME SUBUNITBETA TYPE-10PROTEASOME SUBUNITBETA TYPE-9 (Homo sapiens) |
no annotation | 5 | THR A 1SER A 21LYS A 33ALA A 49SER B 118 | None | 0.69A | 5l5fY-6avoA:25.35l5fZ-6avoA:25.5 | 5l5fY-6avoA:20.385l5fZ-6avoA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6avo | PROTEASOME SUBUNITBETA TYPE-10PROTEASOME SUBUNITBETA TYPE-9 (Homo sapiens) |
no annotation | 4 | THR A 1SER A 21LYS A 33SER B 120 | None | 0.95A | 5l5fY-6avoA:25.35l5fZ-6avoA:25.5 | 5l5fY-6avoA:20.385l5fZ-6avoA:17.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6avo | PROTEASOME SUBUNITBETA TYPE-8 (Homo sapiens) |
no annotation | 5 | THR C 1SER C 21LYS C 33MET C 45ALA C 49 | BZ7 C 301 (-4.0A)BZ7 C 301 (-4.9A)BZ7 C 301 ( 4.8A)BZ7 C 301 ( 4.7A)BZ7 C 301 (-2.8A) | 0.59A | 5l5fY-6avoC:34.55l5fZ-6avoC:24.6 | 5l5fY-6avoC:100.005l5fZ-6avoC:14.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6avo | PROTEASOME SUBUNITBETA TYPE-8 (Homo sapiens) |
no annotation | 5 | THR C 1SER C 21SER C 27MET C 45ALA C 49 | BZ7 C 301 (-4.0A)BZ7 C 301 (-4.9A)BZ7 C 301 (-3.4A)BZ7 C 301 ( 4.7A)BZ7 C 301 (-2.8A) | 0.69A | 5l5fY-6avoC:34.55l5fZ-6avoC:24.6 | 5l5fY-6avoC:100.005l5fZ-6avoC:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bgi | ANOCTAMIN-1 (Mus musculus) |
no annotation | 4 | THR A 422MET A 416ALA A 345SER A 346 | None | 1.08A | 5l5fY-6bgiA:undetectable5l5fZ-6bgiA:undetectable | 5l5fY-6bgiA:20.565l5fZ-6bgiA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c4n | PSEUDOPALINEDEHYDROGENASE (Pseudomonasaeruginosa) |
no annotation | 4 | THR A 216SER A 149LYS A 368ALA A 128 | NoneNoneNAP A 501 ( 4.9A)None | 0.98A | 5l5fY-6c4nA:undetectable5l5fZ-6c4nA:undetectable | 5l5fY-6c4nA:15.645l5fZ-6c4nA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6es9 | ACYL-COADEHYDROGENASE (Paracoccusdenitrificans) |
no annotation | 4 | THR A 165ALA A 230ASP A 479SER A 228 | None | 1.07A | 5l5fY-6es9A:0.05l5fZ-6es9A:undetectable | 5l5fY-6es9A:17.455l5fZ-6es9A:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fu4 | PROBABLE CHEMOTAXISTRANSDUCER (Pseudomonasaeruginosa) |
no annotation | 4 | THR A 194ALA A 187ASP A 206SER A 185 | None | 1.07A | 5l5fY-6fu4A:undetectable5l5fZ-6fu4A:0.6 | 5l5fY-6fu4A:12.805l5fZ-6fu4A:13.51 |