SIMILAR PATTERNS OF AMINO ACIDS FOR 5L5F_K_BO2K301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		5 SER A 142
SER A 146
VAL A 188
LYS A 184
SER A 169
 None
 0.98A 5l5fK-2cw6A:
0.0
5l5fL-2cw6A:
0.0		 5l5fK-2cw6A:
21.04
5l5fL-2cw6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 5 THR H 301
SER H 327
VAL H 331
LYS H 333
ALA H 349
 None
 0.43A 5l5fK-2fhgH:
25.6
5l5fL-2fhgH:
22.1		 5l5fK-2fhgH:
26.67
5l5fL-2fhgH:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens) 		PF03067
(LPMO_10) 		5 THR A  55
SER A  50
VAL A  32
ALA A  11
SER A   9
 None
 1.21A 5l5fK-2lhsA:
undetectable
5l5fL-2lhsA:
undetectable		 5l5fK-2lhsA:
22.12
5l5fL-2lhsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 SER A 246
SER A 250
VAL A 295
ALA A 670
SER A 653
 None
 1.48A 5l5fK-3x1lA:
undetectable
5l5fL-3x1lA:
0.0		 5l5fK-3x1lA:
15.91
5l5fL-3x1lA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2
CAPSID PROTEIN VP3

(Enterovirus D) 		PF00073
(Rhv) 		5 THR C  31
VAL B  48
MET C  34
ALA B 196
ASP B 199
 None
 1.25A 5l5fK-5bnnC:
undetectable
5l5fL-5bnnC:
0.0		 5l5fK-5bnnC:
20.23
5l5fL-5bnnC:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 THR L   1
SER L  21
VAL L  31
MET L  45
ALA L  49
 None
 0.85A 5l5fK-5fmgL:
28.4
5l5fL-5fmgL:
23.5		 5l5fK-5fmgL:
48.58
5l5fL-5fmgL:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 THR A 109
VAL A  39
ALA A  75
ASP A  72
SER A  70
 None
 1.38A 5l5fK-5lhkA:
0.0
5l5fL-5lhkA:
0.0		 5l5fK-5lhkA:
17.76
5l5fL-5lhkA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		7 THR K   1
SER K  21
SER K  27
VAL K  31
LYS K  33
MET K  45
ALA K  49
 7DX  K 301 (-3.3A)
None
7DX  K 301 ( 4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.2A)
 0.36A 5l5fK-5m2bK:
40.1
5l5fL-5m2bK:
23.8		 5l5fK-5m2bK:
100.00
5l5fL-5m2bK:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10
PROTEASOME SUBUNIT
BETA TYPE-9

(Homo sapiens) 		no annotation 5 THR A   1
SER A  21
LYS A  33
ALA A  49
SER B 118
 None
 0.69A 5l5fK-6avoA:
25.3
5l5fL-6avoA:
25.2		 5l5fK-6avoA:
20.38
5l5fL-6avoA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 6 THR C   1
SER C  21
SER C  27
VAL C  31
MET C  45
ALA C  49
 BZ7  C 301 (-4.0A)
BZ7  C 301 (-4.9A)
BZ7  C 301 (-3.4A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-2.8A)
 0.75A 5l5fK-6avoC:
34.5
5l5fL-6avoC:
24.5		 5l5fK-6avoC:
100.00
5l5fL-6avoC:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 6 THR C   1
SER C  21
VAL C  31
LYS C  33
MET C  45
ALA C  49
 BZ7  C 301 (-4.0A)
BZ7  C 301 (-4.9A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-2.8A)
 0.66A 5l5fK-6avoC:
34.5
5l5fL-6avoC:
24.5		 5l5fK-6avoC:
100.00
5l5fL-6avoC:
14.55