SIMILAR PATTERNS OF AMINO ACIDS FOR 5L4I_A_6J3A201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c07 PROTEIN (EPIDERMAL
GROWTH FACTOR
RECEPTOR PATHWAY
SUBSTRATE 15)

(Homo sapiens) 		PF12763
(EF-hand_4) 		4 LEU A  80
LEU A  60
SER A  59
THR A  63
 None
 1.02A 5l4iA-1c07A:
undetectable		 5l4iA-1c07A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 506
ALA A 563
LEU A 565
THR A 576
 None
 0.65A 5l4iA-1g0dA:
3.6		 5l4iA-1g0dA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.32A 5l4iA-1gkeA:
22.1		 5l4iA-1gkeA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
SER A 117
THR A 119
 None
 0.84A 5l4iA-1gkeA:
22.1		 5l4iA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		5 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.44A 5l4iA-1guqA:
undetectable		 5l4iA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II

(Clostridium
pasteurianum) 		PF03459
(TOBE) 		4 LYS A  18
LEU A  16
ALA A  23
SER A  37
 None
 0.94A 5l4iA-1gutA:
undetectable		 5l4iA-1gutA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.30A 5l4iA-1hjuA:
undetectable		 5l4iA-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 LEU A 183
ALA A 179
LEU A 185
THR A 176
 None
 0.92A 5l4iA-1i36A:
undetectable		 5l4iA-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.91A 5l4iA-1j0aA:
undetectable		 5l4iA-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LEU A1081
ALA A1098
LEU A1083
SER A1085
 None
 1.04A 5l4iA-1jl5A:
undetectable		 5l4iA-1jl5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LEU A 585
ALA A 291
LEU A 293
THR A 305
 None
 0.80A 5l4iA-1k25A:
undetectable		 5l4iA-1k25A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A 361
ALA A 357
LEU A 363
THR A 354
 None
 0.89A 5l4iA-1l5jA:
undetectable		 5l4iA-1l5jA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A2906
ALA A2948
LEU A2946
SER A2933
 None
 0.95A 5l4iA-1miuA:
undetectable		 5l4iA-1miuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  36
LEU A  38
SER A  50
THR A  52
 None
 1.00A 5l4iA-1rvkA:
undetectable		 5l4iA-1rvkA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.95A 5l4iA-1sb3B:
undetectable		 5l4iA-1sb3B:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
THR A 119
 None
 0.42A 5l4iA-1sn2A:
20.6		 5l4iA-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.88A 5l4iA-1sn2A:
20.6		 5l4iA-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 LEU A 352
ALA A 323
LEU A 349
SER A 326
THR A 374
 None
 1.43A 5l4iA-1sqgA:
undetectable		 5l4iA-1sqgA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 OKT3 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H   4
ALA H  79
SER H  77
THR H  72
 None
 0.98A 5l4iA-1sy6H:
undetectable		 5l4iA-1sy6H:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
THR A 119
 None
 0.33A 5l4iA-1tfpA:
19.6		 5l4iA-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.84A 5l4iA-1tfpA:
19.6		 5l4iA-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.62A 5l4iA-1uunA:
undetectable		 5l4iA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		4 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 0.98A 5l4iA-1xg2A:
undetectable		 5l4iA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.04A 5l4iA-1xvyA:
undetectable		 5l4iA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx0 PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		4 LEU A 275
ALA A 341
LEU A 292
SER A 346
 None
 1.04A 5l4iA-1xx0A:
undetectable		 5l4iA-1xx0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.72A 5l4iA-1yr2A:
undetectable		 5l4iA-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.97A 5l4iA-2eyqA:
undetectable		 5l4iA-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3n IG LAMBDA-5

(Homo sapiens) 		PF07654
(C1-set) 		4 LEU B  96
ALA B  94
LEU B 142
THR B 145
 None
 1.04A 5l4iA-2h3nB:
undetectable		 5l4iA-2h3nB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		4 LEU A  79
LEU A  80
SER A  87
THR A  89
 None
 1.05A 5l4iA-2jftA:
undetectable		 5l4iA-2jftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc3 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 1.03A 5l4iA-2kc3A:
undetectable		 5l4iA-2kc3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 LEU A 208
ALA A  57
LEU A 142
SER A 141
THR A  54
 None
 1.24A 5l4iA-2nlzA:
undetectable		 5l4iA-2nlzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.03A 5l4iA-2o3jA:
undetectable		 5l4iA-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 0.97A 5l4iA-2pv7A:
undetectable		 5l4iA-2pv7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 LEU A  62
ALA A 164
LEU A 166
THR A 176
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
 0.59A 5l4iA-2v9uA:
3.2		 5l4iA-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 LEU A  49
ALA A  38
LEU A  51
THR A  34
 None
 0.67A 5l4iA-2w6dA:
undetectable		 5l4iA-2w6dA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 LEU B 585
ALA B 291
LEU B 293
THR B 305
 None
 0.78A 5l4iA-2z2mB:
undetectable		 5l4iA-2z2mB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 LEU A 257
ALA A 121
LEU A 254
THR A 252
 None
FAD  A1002 (-3.5A)
None
None
 1.04A 5l4iA-2zbwA:
undetectable		 5l4iA-2zbwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.94A 5l4iA-3aqpA:
undetectable		 5l4iA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.90A 5l4iA-3b8kA:
undetectable		 5l4iA-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.93A 5l4iA-3bdwB:
undetectable		 5l4iA-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A  46
ALA A  44
LEU A  40
SER A  41
 None
 0.94A 5l4iA-3bjlA:
3.4		 5l4iA-3bjlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3d LYSOZYME

(Escherichia
virus Lambda) 		PF00959
(Phage_lysozyme) 		4 LEU A  12
LEU A  15
SER A  18
THR A  21
 None
 1.01A 5l4iA-3d3dA:
undetectable		 5l4iA-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.85A 5l4iA-3eyaA:
undetectable		 5l4iA-3eyaA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
 0.34A 5l4iA-3fc8A:
24.1		 5l4iA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		4 LEU A 461
ALA A 377
LEU A 379
SER A 363
 None
 0.94A 5l4iA-3ftjA:
undetectable		 5l4iA-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		4 ALA A 756
LEU A 804
SER A 720
THR A 801
 None
 1.04A 5l4iA-3g9hA:
undetectable		 5l4iA-3g9hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.01A 5l4iA-3go1L:
undetectable		 5l4iA-3go1L:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01402
(RHH_1) 		4 LEU C  24
ALA C  22
LEU C  26
SER C  27
 GOL  C  74 (-4.3A)
None
None
None
 1.00A 5l4iA-3h87C:
undetectable		 5l4iA-3h87C:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 400
ALA A 235
LEU A 237
THR A 302
 None
 0.86A 5l4iA-3hdiA:
undetectable		 5l4iA-3hdiA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 0.98A 5l4iA-3ig3A:
undetectable		 5l4iA-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
 0.75A 5l4iA-3iwkA:
undetectable		 5l4iA-3iwkA:
13.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwu 5-HYDROXYISOURATE
HYDROLASE

(Danio rerio) 		PF00576
(Transthyretin) 		4 LEU A  14
LEU A 107
SER A 114
THR A 116
 None
 0.91A 5l4iA-3iwuA:
19.6		 5l4iA-3iwuA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.02A 5l4iA-3kbhA:
undetectable		 5l4iA-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA

(Homo sapiens) 		PF00293
(NUDIX) 		4 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 5l4iA-3mcfA:
undetectable		 5l4iA-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj8 STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
LIGHT CHAIN

(Cricetulus
migratorius) 		no annotation 4 LEU L 132
ALA L 130
LEU L 179
THR L 182
 None
 1.04A 5l4iA-3mj8L:
undetectable		 5l4iA-3mj8L:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.01A 5l4iA-3mluL:
2.9		 5l4iA-3mluL:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 0.99A 5l4iA-3mmtA:
undetectable		 5l4iA-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1

(Saccharomyces
cerevisiae) 		PF12539
(Csm1) 		4 LYS A 119
ALA A 135
SER A 162
THR A 160
 None
 1.02A 5l4iA-3n4xA:
undetectable		 5l4iA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		4 LEU A 187
ALA A 185
LEU A 189
SER A 190
 None
 1.04A 5l4iA-3p7nA:
undetectable		 5l4iA-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 1.00A 5l4iA-3peiA:
undetectable		 5l4iA-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqj BIOFILM
GROWTH-ASSOCIATED
REPRESSOR

(Xylella
fastidiosa) 		PF12840
(HTH_20) 		4 LEU A  72
LEU A  69
SER A  66
THR A  64
 None
 1.01A 5l4iA-3pqjA:
undetectable		 5l4iA-3pqjA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 280
LEU B 264
SER B 317
THR B 319
 None
 0.58A 5l4iA-3prxB:
3.4		 5l4iA-3prxB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU K 135
ALA K 133
LEU K 181
THR K 184
 None
 1.02A 5l4iA-3ri5K:
undetectable		 5l4iA-3ri5K:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		4 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.89A 5l4iA-3s3tA:
undetectable		 5l4iA-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.91A 5l4iA-3sagA:
undetectable		 5l4iA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 133
ALA L 131
LEU L 179
THR L 182
 None
 1.03A 5l4iA-3t2nL:
undetectable		 5l4iA-3t2nL:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		4 LEU A  58
ALA A  49
SER A  44
THR A  48
 None
 0.90A 5l4iA-3t38A:
undetectable		 5l4iA-3t38A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 240
ALA A 243
LEU A 239
THR A 187
 None
 0.91A 5l4iA-3t6sA:
undetectable		 5l4iA-3t6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		4 LEU A 268
ALA A 266
LEU A 273
THR A 264
 None
 0.91A 5l4iA-3uk2A:
undetectable		 5l4iA-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 LYS A 323
ALA A 168
SER A  92
THR A  94
 None
 0.91A 5l4iA-3ut3A:
undetectable		 5l4iA-3ut3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LYS A  96
LEU A 100
LEU A  35
SER A  34
 NAP  A 291 (-3.1A)
None
None
None
 0.90A 5l4iA-3uxjA:
undetectable		 5l4iA-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1171
ALA B1047
LEU B1049
SER B1249
 None
 0.97A 5l4iA-3zefB:
undetectable		 5l4iA-3zefB:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.95A 5l4iA-4a7kA:
undetectable		 5l4iA-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G

(Escherichia
coli) 		PF09381
(Porin_OmpG) 		4 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.65A 5l4iA-4ctdA:
undetectable		 5l4iA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH

(Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.01A 5l4iA-4cxfA:
undetectable		 5l4iA-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 257
ALA A 243
LEU A 241
THR A 204
 None
 0.98A 5l4iA-4dyjA:
undetectable		 5l4iA-4dyjA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 LYS A 421
ALA A 417
LEU A  91
SER A  87
 None
 1.03A 5l4iA-4g3jA:
undetectable		 5l4iA-4g3jA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A 411
LEU A 405
SER A 402
THR A 414
 None
 1.04A 5l4iA-4gw9A:
undetectable		 5l4iA-4gw9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		4 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.04A 5l4iA-4hfoA:
undetectable		 5l4iA-4hfoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 LEU A 184
LEU A 157
SER A 235
THR A 237
 None
None
None
NAD  A 601 (-4.2A)
 0.76A 5l4iA-4i8qA:
undetectable		 5l4iA-4i8qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 0.98A 5l4iA-4jy4A:
undetectable		 5l4iA-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 LEU A  86
ALA A  41
SER A  13
THR A  11
 None
 0.71A 5l4iA-4l1yA:
undetectable		 5l4iA-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llq MUTATED LIGHT CHAIN
CLAMBDA

(Homo sapiens) 		PF07654
(C1-set) 		4 LEU B 136
ALA B 134
LEU B 182
THR B 185
 None
 1.04A 5l4iA-4llqB:
undetectable		 5l4iA-4llqB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llu LIGHT CHAIN CLAMBDA

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 133
ALA B 131
LEU B 179
THR B 182
 None
 1.02A 5l4iA-4lluB:
undetectable		 5l4iA-4lluB:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 0.98A 5l4iA-4lsuL:
undetectable		 5l4iA-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 447
LEU A 452
SER A 453
THR A 455
 None
 1.01A 5l4iA-4m7eA:
undetectable		 5l4iA-4m7eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.77A 5l4iA-4mr0A:
undetectable		 5l4iA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pg6 HOMOSERINE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LYS A 184
LEU A 180
ALA A 189
SER A 162
 None
 0.99A 5l4iA-4pg6A:
undetectable		 5l4iA-4pg6A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C 104
ALA C  22
LEU C  18
SER C  17
 None
 1.01A 5l4iA-4ptzC:
undetectable		 5l4iA-4ptzC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9c NOVEL ANTIGEN
RECEPTOR

(Ginglymostoma
cirratum) 		PF07654
(C1-set) 		4 LEU A 370
ALA A 368
LEU A 416
THR A 419
 None
 1.01A 5l4iA-4q9cA:
undetectable		 5l4iA-4q9cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LYS A 409
LEU A 411
LEU A 454
THR A 447
 None
None
None
SEP  A 695 ( 4.8A)
 0.69A 5l4iA-4q9zA:
undetectable		 5l4iA-4q9zA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59

(Homo sapiens) 		no annotation 4 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.00A 5l4iA-4qf1L:
undetectable		 5l4iA-4qf1L:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyb UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF10765
(DUF2591) 		4 LEU A  98
ALA A 102
SER A  94
THR A 105
 None
 0.92A 5l4iA-4qybA:
undetectable		 5l4iA-4qybA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 132
ALA B 130
LEU B 178
THR B 181
 None
 1.02A 5l4iA-4rnrB:
undetectable		 5l4iA-4rnrB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.66A 5l4iA-4tr6A:
undetectable		 5l4iA-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.97A 5l4iA-4w65A:
undetectable		 5l4iA-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		4 LEU C 413
ALA C 466
LEU C 410
THR C 470
 None
 1.03A 5l4iA-4xgcC:
undetectable		 5l4iA-4xgcC:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxx DTOR_6X35L

(synthetic
construct) 		no annotation 4 LEU A   7
ALA A 188
LEU A  10
THR A 193
 None
 0.99A 5l4iA-4yxxA:
undetectable		 5l4iA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxx DTOR_6X35L

(synthetic
construct) 		no annotation 4 LEU A  77
ALA A  48
LEU A  80
THR A  53
 None
 1.03A 5l4iA-4yxxA:
undetectable		 5l4iA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.05A 5l4iA-4zs7L:
undetectable		 5l4iA-4zs7L:
23.50