SIMILAR PATTERNS OF AMINO ACIDS FOR 5L4E_D_EDPD402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.99A 5l4eA-1bfoA:
1.0
5l4eB-1bfoA:
undetectable
5l4eC-1bfoA:
undetectable
5l4eD-1bfoA:
1.0
5l4eE-1bfoA:
undetectable		 5l4eA-1bfoA:
20.31
5l4eB-1bfoA:
20.31
5l4eC-1bfoA:
20.31
5l4eD-1bfoA:
20.31
5l4eE-1bfoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.99A 5l4eA-1dqlL:
2.2
5l4eB-1dqlL:
2.2
5l4eC-1dqlL:
2.1
5l4eD-1dqlL:
2.3
5l4eE-1dqlL:
2.2		 5l4eA-1dqlL:
15.14
5l4eB-1dqlL:
15.14
5l4eC-1dqlL:
15.14
5l4eD-1dqlL:
15.14
5l4eE-1dqlL:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek3 KAPPA-4
IMMUNOGLOBULIN LIGHT
CHAIN VL

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.99A 5l4eA-1ek3A:
undetectable
5l4eB-1ek3A:
undetectable
5l4eC-1ek3A:
undetectable
5l4eD-1ek3A:
undetectable
5l4eE-1ek3A:
undetectable		 5l4eA-1ek3A:
18.21
5l4eB-1ek3A:
18.21
5l4eC-1ek3A:
18.21
5l4eD-1ek3A:
18.21
5l4eE-1ek3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PROLACTIN RECEPTOR

(Rattus
norvegicus) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 SER B 198
THR B 110
THR B 182
SER B 195
 None
 0.97A 5l4eA-1f6fB:
undetectable
5l4eB-1f6fB:
2.5
5l4eC-1f6fB:
undetectable
5l4eD-1f6fB:
0.0
5l4eE-1f6fB:
undetectable		 5l4eA-1f6fB:
22.36
5l4eB-1f6fB:
22.36
5l4eC-1f6fB:
22.36
5l4eD-1f6fB:
22.36
5l4eE-1f6fB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PROLACTIN RECEPTOR

(Rattus
norvegicus) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 THR B 182
SER B 195
SER B 198
THR B 110
 None
 0.98A 5l4eA-1f6fB:
undetectable
5l4eB-1f6fB:
2.5
5l4eC-1f6fB:
undetectable
5l4eD-1f6fB:
0.0
5l4eE-1f6fB:
undetectable		 5l4eA-1f6fB:
22.36
5l4eB-1f6fB:
22.36
5l4eC-1f6fB:
22.36
5l4eD-1f6fB:
22.36
5l4eE-1f6fB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER A 113
THR A 111
SER A 171
THR B 175
 None
 0.88A 5l4eA-1fn4A:
1.2
5l4eB-1fn4A:
3.3
5l4eC-1fn4A:
2.0
5l4eD-1fn4A:
1.9
5l4eE-1fn4A:
1.0		 5l4eA-1fn4A:
20.25
5l4eB-1fn4A:
20.25
5l4eC-1fn4A:
20.25
5l4eD-1fn4A:
20.25
5l4eE-1fn4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B 175
SER A 113
THR A 111
SER A 171
 None
 0.92A 5l4eA-1fn4B:
undetectable
5l4eB-1fn4B:
undetectable
5l4eC-1fn4B:
undetectable
5l4eD-1fn4B:
0.0
5l4eE-1fn4B:
undetectable		 5l4eA-1fn4B:
19.81
5l4eB-1fn4B:
19.81
5l4eC-1fn4B:
19.81
5l4eD-1fn4B:
19.81
5l4eE-1fn4B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 THR B 100
SER B 118
THR B  98
SER B 120
 None
 0.91A 5l4eA-1fngB:
2.6
5l4eB-1fngB:
2.6
5l4eC-1fngB:
2.3
5l4eD-1fngB:
2.6
5l4eE-1fngB:
2.6		 5l4eA-1fngB:
22.47
5l4eB-1fngB:
22.47
5l4eC-1fngB:
22.47
5l4eD-1fngB:
22.47
5l4eE-1fngB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 THR A 535
SER A 553
THR A 533
SER A 555
 None
 0.95A 5l4eA-1knbA:
undetectable
5l4eB-1knbA:
undetectable
5l4eC-1knbA:
undetectable
5l4eD-1knbA:
undetectable
5l4eE-1knbA:
undetectable		 5l4eA-1knbA:
21.77
5l4eB-1knbA:
21.77
5l4eC-1knbA:
21.77
5l4eD-1knbA:
21.77
5l4eE-1knbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk3 9D7 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  73
SER L  62
THR L  71
SER L  64
 None
 1.02A 5l4eA-1lk3L:
1.9
5l4eB-1lk3L:
3.3
5l4eC-1lk3L:
2.3
5l4eD-1lk3L:
1.6
5l4eE-1lk3L:
1.9		 5l4eA-1lk3L:
21.95
5l4eB-1lk3L:
21.95
5l4eC-1lk3L:
21.95
5l4eD-1lk3L:
21.95
5l4eE-1lk3L:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 THR A 208
SER A 149
THR A 206
SER A 151
 None
 0.96A 5l4eA-1nr9A:
undetectable
5l4eB-1nr9A:
undetectable
5l4eC-1nr9A:
undetectable
5l4eD-1nr9A:
undetectable
5l4eE-1nr9A:
undetectable		 5l4eA-1nr9A:
18.18
5l4eB-1nr9A:
18.18
5l4eC-1nr9A:
18.18
5l4eD-1nr9A:
18.18
5l4eE-1nr9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER L 116
THR L 114
SER L 174
THR H 182
 None
 0.99A 5l4eA-1uywL:
undetectable
5l4eB-1uywL:
3.3
5l4eC-1uywL:
undetectable
5l4eD-1uywL:
undetectable
5l4eE-1uywL:
3.3		 5l4eA-1uywL:
18.93
5l4eB-1uywL:
18.93
5l4eC-1uywL:
18.93
5l4eD-1uywL:
18.93
5l4eE-1uywL:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wtl BENCE-JONES PROTEIN
MCG (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.92A 5l4eA-1wtlA:
undetectable
5l4eB-1wtlA:
undetectable
5l4eC-1wtlA:
undetectable
5l4eD-1wtlA:
undetectable
5l4eE-1wtlA:
undetectable		 5l4eA-1wtlA:
16.72
5l4eB-1wtlA:
16.72
5l4eC-1wtlA:
16.72
5l4eD-1wtlA:
16.72
5l4eE-1wtlA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 THR A 209
SER A 228
THR A 207
SER A 230
 None
 0.96A 5l4eA-1ydwA:
undetectable
5l4eB-1ydwA:
undetectable
5l4eC-1ydwA:
undetectable
5l4eD-1ydwA:
undetectable
5l4eE-1ydwA:
undetectable		 5l4eA-1ydwA:
21.91
5l4eB-1ydwA:
21.91
5l4eC-1ydwA:
21.91
5l4eD-1ydwA:
21.91
5l4eE-1ydwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 THR A 356
THR A 308
THR A 258
SER A 255
 None
 1.03A 5l4eA-1yzyA:
undetectable
5l4eB-1yzyA:
undetectable
5l4eC-1yzyA:
undetectable
5l4eD-1yzyA:
undetectable
5l4eE-1yzyA:
1.4		 5l4eA-1yzyA:
22.51
5l4eB-1yzyA:
22.51
5l4eC-1yzyA:
22.51
5l4eD-1yzyA:
22.51
5l4eE-1yzyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		4 THR A 195
SER A 108
THR A 193
SER A 110
 None
 1.02A 5l4eA-2d3rA:
undetectable
5l4eB-2d3rA:
undetectable
5l4eC-2d3rA:
undetectable
5l4eD-2d3rA:
undetectable
5l4eE-2d3rA:
undetectable		 5l4eA-2d3rA:
23.33
5l4eB-2d3rA:
23.33
5l4eC-2d3rA:
23.33
5l4eD-2d3rA:
23.33
5l4eE-2d3rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.01A 5l4eA-2d7tL:
undetectable
5l4eB-2d7tL:
undetectable
5l4eC-2d7tL:
undetectable
5l4eD-2d7tL:
undetectable
5l4eE-2d7tL:
undetectable		 5l4eA-2d7tL:
17.78
5l4eB-2d7tL:
17.78
5l4eC-2d7tL:
17.78
5l4eD-2d7tL:
17.78
5l4eE-2d7tL:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.03A 5l4eA-2f5aL:
undetectable
5l4eB-2f5aL:
undetectable
5l4eC-2f5aL:
undetectable
5l4eD-2f5aL:
undetectable
5l4eE-2f5aL:
3.1		 5l4eA-2f5aL:
22.77
5l4eB-2f5aL:
22.77
5l4eC-2f5aL:
22.77
5l4eD-2f5aL:
22.77
5l4eE-2f5aL:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 SER A 107
THR A 102
THR A 202
SER A 149
 None
 1.01A 5l4eA-2fyiA:
undetectable
5l4eB-2fyiA:
undetectable
5l4eC-2fyiA:
undetectable
5l4eD-2fyiA:
undetectable
5l4eE-2fyiA:
undetectable		 5l4eA-2fyiA:
21.74
5l4eB-2fyiA:
21.74
5l4eC-2fyiA:
21.74
5l4eD-2fyiA:
21.74
5l4eE-2fyiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Streptococcus
pyogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 SER A 142
THR A  94
THR A  44
SER A  10
 None
None
None
EDO  A 502 (-3.8A)
 0.96A 5l4eA-2gs8A:
1.6
5l4eB-2gs8A:
undetectable
5l4eC-2gs8A:
1.6
5l4eD-2gs8A:
1.6
5l4eE-2gs8A:
1.6		 5l4eA-2gs8A:
20.00
5l4eB-2gs8A:
20.00
5l4eC-2gs8A:
20.00
5l4eD-2gs8A:
20.00
5l4eE-2gs8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmz TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
12A

(Homo sapiens) 		PF12191
(stn_TNFRSF12A) 		4 SER A  16
SER A  34
SER A  27
THR A   6
 None
 1.03A 5l4eA-2kmzA:
undetectable
5l4eB-2kmzA:
undetectable
5l4eC-2kmzA:
undetectable
5l4eD-2kmzA:
undetectable
5l4eE-2kmzA:
undetectable		 5l4eA-2kmzA:
9.24
5l4eB-2kmzA:
9.24
5l4eC-2kmzA:
9.24
5l4eD-2kmzA:
9.24
5l4eE-2kmzA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB

(Mycobacterium
tuberculosis) 		PF04972
(BON) 		4 THR A  92
SER A  85
THR A  90
SER A  87
 None
 0.90A 5l4eA-2ksmA:
undetectable
5l4eB-2ksmA:
undetectable
5l4eC-2ksmA:
undetectable
5l4eD-2ksmA:
undetectable
5l4eE-2ksmA:
undetectable		 5l4eA-2ksmA:
19.31
5l4eB-2ksmA:
19.31
5l4eC-2ksmA:
19.31
5l4eD-2ksmA:
19.31
5l4eE-2ksmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 SER B 342
THR B 348
SER B 344
THR B  55
 None
 0.95A 5l4eA-2pbiB:
undetectable
5l4eB-2pbiB:
undetectable
5l4eC-2pbiB:
undetectable
5l4eD-2pbiB:
undetectable
5l4eE-2pbiB:
undetectable		 5l4eA-2pbiB:
20.84
5l4eB-2pbiB:
20.84
5l4eC-2pbiB:
20.84
5l4eD-2pbiB:
20.84
5l4eE-2pbiB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 THR B  55
SER B 342
THR B 348
SER B 344
 None
 0.91A 5l4eA-2pbiB:
undetectable
5l4eB-2pbiB:
undetectable
5l4eC-2pbiB:
undetectable
5l4eD-2pbiB:
undetectable
5l4eE-2pbiB:
undetectable		 5l4eA-2pbiB:
20.84
5l4eB-2pbiB:
20.84
5l4eC-2pbiB:
20.84
5l4eD-2pbiB:
20.84
5l4eE-2pbiB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 SER A  56
THR A 115
THR A 129
THR A 100
 None
 1.01A 5l4eA-2w1jA:
undetectable
5l4eB-2w1jA:
undetectable
5l4eC-2w1jA:
undetectable
5l4eD-2w1jA:
undetectable
5l4eE-2w1jA:
undetectable		 5l4eA-2w1jA:
22.46
5l4eB-2w1jA:
22.46
5l4eC-2w1jA:
22.46
5l4eD-2w1jA:
22.46
5l4eE-2w1jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 SER A 320
THR A 326
SER A 322
THR A 300
 None
 1.00A 5l4eA-2ymuA:
undetectable
5l4eB-2ymuA:
undetectable
5l4eC-2ymuA:
undetectable
5l4eD-2ymuA:
undetectable
5l4eE-2ymuA:
undetectable		 5l4eA-2ymuA:
20.64
5l4eB-2ymuA:
20.64
5l4eC-2ymuA:
20.64
5l4eD-2ymuA:
20.64
5l4eE-2ymuA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 THR A 300
SER A 320
THR A 326
SER A 322
 None
 0.98A 5l4eA-2ymuA:
undetectable
5l4eB-2ymuA:
undetectable
5l4eC-2ymuA:
undetectable
5l4eD-2ymuA:
undetectable
5l4eE-2ymuA:
undetectable		 5l4eA-2ymuA:
20.64
5l4eB-2ymuA:
20.64
5l4eC-2ymuA:
20.64
5l4eD-2ymuA:
20.64
5l4eE-2ymuA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zab ALGINATE LYASE

(Sphingomonas
sp. A1) 		PF08787
(Alginate_lyase2) 		4 THR A 169
SER A 305
THR A 167
SER A 307
 None
 0.73A 5l4eA-2zabA:
undetectable
5l4eB-2zabA:
undetectable
5l4eC-2zabA:
undetectable
5l4eD-2zabA:
undetectable
5l4eE-2zabA:
undetectable		 5l4eA-2zabA:
19.88
5l4eB-2zabA:
19.88
5l4eC-2zabA:
19.88
5l4eD-2zabA:
19.88
5l4eE-2zabA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 195
THR A 201
SER A 197
THR A 212
 None
 0.99A 5l4eA-3acpA:
undetectable
5l4eB-3acpA:
undetectable
5l4eC-3acpA:
undetectable
5l4eD-3acpA:
undetectable
5l4eE-3acpA:
undetectable		 5l4eA-3acpA:
20.65
5l4eB-3acpA:
20.65
5l4eC-3acpA:
20.65
5l4eD-3acpA:
20.65
5l4eE-3acpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 THR A 212
SER A 195
THR A 201
SER A 197
 None
 0.96A 5l4eA-3acpA:
undetectable
5l4eB-3acpA:
undetectable
5l4eC-3acpA:
undetectable
5l4eD-3acpA:
undetectable
5l4eE-3acpA:
undetectable		 5l4eA-3acpA:
20.65
5l4eB-3acpA:
20.65
5l4eC-3acpA:
20.65
5l4eD-3acpA:
20.65
5l4eE-3acpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  85
SER A  74
THR A  83
SER A  76
 None
 1.01A 5l4eA-3auvA:
undetectable
5l4eB-3auvA:
undetectable
5l4eC-3auvA:
undetectable
5l4eD-3auvA:
undetectable
5l4eE-3auvA:
undetectable		 5l4eA-3auvA:
20.50
5l4eB-3auvA:
20.50
5l4eC-3auvA:
20.50
5l4eD-3auvA:
20.50
5l4eE-3auvA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 THR A 121
SER A  82
THR A 141
SER A 116
 None
 0.91A 5l4eA-3c8vA:
undetectable
5l4eB-3c8vA:
undetectable
5l4eC-3c8vA:
undetectable
5l4eD-3c8vA:
undetectable
5l4eE-3c8vA:
undetectable		 5l4eA-3c8vA:
21.16
5l4eB-3c8vA:
21.16
5l4eC-3c8vA:
21.16
5l4eD-3c8vA:
21.16
5l4eE-3c8vA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 THR A 141
SER A 116
THR A 121
SER A  82
 None
 0.94A 5l4eA-3c8vA:
undetectable
5l4eB-3c8vA:
undetectable
5l4eC-3c8vA:
undetectable
5l4eD-3c8vA:
undetectable
5l4eE-3c8vA:
undetectable		 5l4eA-3c8vA:
21.16
5l4eB-3c8vA:
21.16
5l4eC-3c8vA:
21.16
5l4eD-3c8vA:
21.16
5l4eE-3c8vA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdf IMMUNOGLOBULIN LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.82A 5l4eA-3cdfA:
undetectable
5l4eB-3cdfA:
undetectable
5l4eC-3cdfA:
2.4
5l4eD-3cdfA:
undetectable
5l4eE-3cdfA:
2.3		 5l4eA-3cdfA:
16.78
5l4eB-3cdfA:
16.78
5l4eC-3cdfA:
16.78
5l4eD-3cdfA:
16.78
5l4eE-3cdfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 SER A 247
THR A 385
THR A 376
SER A 282
 None
 0.97A 5l4eA-3cqfA:
undetectable
5l4eB-3cqfA:
undetectable
5l4eC-3cqfA:
undetectable
5l4eD-3cqfA:
undetectable
5l4eE-3cqfA:
undetectable		 5l4eA-3cqfA:
23.78
5l4eB-3cqfA:
23.78
5l4eC-3cqfA:
23.78
5l4eD-3cqfA:
23.78
5l4eE-3cqfA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 THR A 363
THR A 315
THR A 263
SER A 260
 None
 0.93A 5l4eA-3dqqA:
undetectable
5l4eB-3dqqA:
undetectable
5l4eC-3dqqA:
undetectable
5l4eD-3dqqA:
1.2
5l4eE-3dqqA:
undetectable		 5l4eA-3dqqA:
22.17
5l4eB-3dqqA:
22.17
5l4eC-3dqqA:
22.17
5l4eD-3dqqA:
22.17
5l4eE-3dqqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 SER A  49
THR A  82
SER A  85
SER A 160
 PLP  A 401 ( 4.4A)
None
None
None
 0.99A 5l4eA-3dwiA:
undetectable
5l4eB-3dwiA:
undetectable
5l4eC-3dwiA:
undetectable
5l4eD-3dwiA:
undetectable
5l4eE-3dwiA:
undetectable		 5l4eA-3dwiA:
23.38
5l4eB-3dwiA:
23.38
5l4eC-3dwiA:
23.38
5l4eD-3dwiA:
23.38
5l4eE-3dwiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 SER A 160
SER A  49
THR A  82
SER A  85
 None
PLP  A 401 ( 4.4A)
None
None
 1.00A 5l4eA-3dwiA:
undetectable
5l4eB-3dwiA:
undetectable
5l4eC-3dwiA:
undetectable
5l4eD-3dwiA:
undetectable
5l4eE-3dwiA:
undetectable		 5l4eA-3dwiA:
23.38
5l4eB-3dwiA:
23.38
5l4eC-3dwiA:
23.38
5l4eD-3dwiA:
23.38
5l4eE-3dwiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 SER A1099
THR A 770
THR A 778
SER A 776
 MD1  A1245 (-2.7A)
None
None
MD1  A1245 ( 4.0A)
 0.98A 5l4eA-3egwA:
undetectable
5l4eB-3egwA:
undetectable
5l4eC-3egwA:
undetectable
5l4eD-3egwA:
undetectable
5l4eE-3egwA:
undetectable		 5l4eA-3egwA:
14.24
5l4eB-3egwA:
14.24
5l4eC-3egwA:
14.24
5l4eD-3egwA:
14.24
5l4eE-3egwA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 4 THR B 217
SER B 206
THR B 215
SER B 208
 None
 0.98A 5l4eA-3juyB:
undetectable
5l4eB-3juyB:
undetectable
5l4eC-3juyB:
undetectable
5l4eD-3juyB:
undetectable
5l4eE-3juyB:
undetectable		 5l4eA-3juyB:
19.21
5l4eB-3juyB:
19.21
5l4eC-3juyB:
19.21
5l4eD-3juyB:
19.21
5l4eE-3juyB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		5 SER B1302
THR B1273
SER B1277
THR B1308
SER B1311
 None
 1.46A 5l4eA-3mzkB:
2.7
5l4eB-3mzkB:
2.6
5l4eC-3mzkB:
2.6
5l4eD-3mzkB:
2.7
5l4eE-3mzkB:
2.6		 5l4eA-3mzkB:
22.82
5l4eB-3mzkB:
22.82
5l4eC-3mzkB:
22.82
5l4eD-3mzkB:
22.82
5l4eE-3mzkB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		5 THR B1308
SER B1311
SER B1302
THR B1273
SER B1277
 None
 1.46A 5l4eA-3mzkB:
2.7
5l4eB-3mzkB:
2.6
5l4eC-3mzkB:
2.6
5l4eD-3mzkB:
2.7
5l4eE-3mzkB:
2.6		 5l4eA-3mzkB:
22.82
5l4eB-3mzkB:
22.82
5l4eC-3mzkB:
22.82
5l4eD-3mzkB:
22.82
5l4eE-3mzkB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g LIGHT CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.01A 5l4eA-3q6gL:
undetectable
5l4eB-3q6gL:
undetectable
5l4eC-3q6gL:
undetectable
5l4eD-3q6gL:
undetectable
5l4eE-3q6gL:
undetectable		 5l4eA-3q6gL:
20.26
5l4eB-3q6gL:
20.26
5l4eC-3q6gL:
20.26
5l4eD-3q6gL:
20.26
5l4eE-3q6gL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6r ANTIBODY 1:7 (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 4 THR L 222
SER L 211
THR L 220
SER L 213
 None
 1.01A 5l4eA-3u6rL:
undetectable
5l4eB-3u6rL:
undetectable
5l4eC-3u6rL:
undetectable
5l4eD-3u6rL:
undetectable
5l4eE-3u6rL:
undetectable		 5l4eA-3u6rL:
17.34
5l4eB-3u6rL:
17.34
5l4eC-3u6rL:
17.34
5l4eD-3u6rL:
17.34
5l4eE-3u6rL:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 THR A  70
THR A 155
SER A   6
THR A 181
 None
 0.87A 5l4eA-3up8A:
undetectable
5l4eB-3up8A:
undetectable
5l4eC-3up8A:
undetectable
5l4eD-3up8A:
undetectable
5l4eE-3up8A:
undetectable		 5l4eA-3up8A:
22.16
5l4eB-3up8A:
22.16
5l4eC-3up8A:
22.16
5l4eD-3up8A:
22.16
5l4eE-3up8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 THR X 164
SER X 157
THR X 162
SER X 159
 None
 0.98A 5l4eA-4crnX:
1.8
5l4eB-4crnX:
undetectable
5l4eC-4crnX:
1.9
5l4eD-4crnX:
1.0
5l4eE-4crnX:
undetectable		 5l4eA-4crnX:
22.25
5l4eB-4crnX:
22.25
5l4eC-4crnX:
22.25
5l4eD-4crnX:
22.25
5l4eE-4crnX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 SER A  80
THR A  86
SER A  82
THR A  97
 None
 0.92A 5l4eA-4d6vA:
undetectable
5l4eB-4d6vA:
undetectable
5l4eC-4d6vA:
undetectable
5l4eD-4d6vA:
undetectable
5l4eE-4d6vA:
undetectable		 5l4eA-4d6vA:
21.89
5l4eB-4d6vA:
21.89
5l4eC-4d6vA:
21.89
5l4eD-4d6vA:
21.89
5l4eE-4d6vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 THR A  97
SER A  80
THR A  86
SER A  82
 None
 0.89A 5l4eA-4d6vA:
undetectable
5l4eB-4d6vA:
undetectable
5l4eC-4d6vA:
undetectable
5l4eD-4d6vA:
undetectable
5l4eE-4d6vA:
undetectable		 5l4eA-4d6vA:
21.89
5l4eB-4d6vA:
21.89
5l4eC-4d6vA:
21.89
5l4eD-4d6vA:
21.89
5l4eE-4d6vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.01A 5l4eA-4ffyL:
undetectable
5l4eB-4ffyL:
undetectable
5l4eC-4ffyL:
undetectable
5l4eD-4ffyL:
undetectable
5l4eE-4ffyL:
undetectable		 5l4eA-4ffyL:
18.06
5l4eB-4ffyL:
18.06
5l4eC-4ffyL:
18.06
5l4eD-4ffyL:
18.06
5l4eE-4ffyL:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6a AP33 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR D  74
SER D  63
THR D  72
SER D  65
 None
 1.00A 5l4eA-4g6aD:
undetectable
5l4eB-4g6aD:
undetectable
5l4eC-4g6aD:
undetectable
5l4eD-4g6aD:
undetectable
5l4eE-4g6aD:
undetectable		 5l4eA-4g6aD:
20.25
5l4eB-4g6aD:
20.25
5l4eC-4g6aD:
20.25
5l4eD-4g6aD:
20.25
5l4eE-4g6aD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.00A 5l4eA-4hjjL:
undetectable
5l4eB-4hjjL:
undetectable
5l4eC-4hjjL:
undetectable
5l4eD-4hjjL:
undetectable
5l4eE-4hjjL:
undetectable		 5l4eA-4hjjL:
21.05
5l4eB-4hjjL:
21.05
5l4eC-4hjjL:
21.05
5l4eD-4hjjL:
21.05
5l4eE-4hjjL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 SER A 351
THR A 278
THR A 380
THR A 287
 None
 0.99A 5l4eA-4hucA:
undetectable
5l4eB-4hucA:
undetectable
5l4eC-4hucA:
undetectable
5l4eD-4hucA:
undetectable
5l4eE-4hucA:
undetectable		 5l4eA-4hucA:
21.43
5l4eB-4hucA:
21.43
5l4eC-4hucA:
21.43
5l4eD-4hucA:
21.43
5l4eE-4hucA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens) 		no annotation 4 THR L  71
SER L  64
THR L  69
SER L  66
 None
 0.97A 5l4eA-4imlL:
undetectable
5l4eB-4imlL:
undetectable
5l4eC-4imlL:
undetectable
5l4eD-4imlL:
undetectable
5l4eE-4imlL:
undetectable		 5l4eA-4imlL:
18.87
5l4eB-4imlL:
18.87
5l4eC-4imlL:
18.87
5l4eD-4imlL:
18.87
5l4eE-4imlL:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llu LIGHT CHAIN CLAMBDA

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  74
SER B  63
THR B  72
SER B  65
 None
 1.03A 5l4eA-4lluB:
undetectable
5l4eB-4lluB:
undetectable
5l4eC-4lluB:
undetectable
5l4eD-4lluB:
undetectable
5l4eE-4lluB:
undetectable		 5l4eA-4lluB:
20.32
5l4eB-4lluB:
20.32
5l4eC-4lluB:
20.32
5l4eD-4lluB:
20.32
5l4eE-4lluB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 SER A 125
THR A 269
SER A 201
THR A 305
 None
 1.03A 5l4eA-4lw6A:
undetectable
5l4eB-4lw6A:
undetectable
5l4eC-4lw6A:
undetectable
5l4eD-4lw6A:
undetectable
5l4eE-4lw6A:
undetectable		 5l4eA-4lw6A:
21.41
5l4eB-4lw6A:
21.41
5l4eC-4lw6A:
21.41
5l4eD-4lw6A:
21.41
5l4eE-4lw6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 THR A 305
SER A 125
THR A 269
SER A 201
 None
 1.01A 5l4eA-4lw6A:
undetectable
5l4eB-4lw6A:
undetectable
5l4eC-4lw6A:
undetectable
5l4eD-4lw6A:
undetectable
5l4eE-4lw6A:
undetectable		 5l4eA-4lw6A:
21.41
5l4eB-4lw6A:
21.41
5l4eC-4lw6A:
21.41
5l4eD-4lw6A:
21.41
5l4eE-4lw6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 SER A1238
THR A1027
SER A1014
THR A1025
 None
 0.91A 5l4eA-4meeA:
undetectable
5l4eB-4meeA:
undetectable
5l4eC-4meeA:
undetectable
5l4eD-4meeA:
undetectable
5l4eE-4meeA:
undetectable		 5l4eA-4meeA:
20.38
5l4eB-4meeA:
20.38
5l4eC-4meeA:
20.38
5l4eD-4meeA:
20.38
5l4eE-4meeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouo ANTI BLA G 1 SCFV

(Gallus gallus) 		PF07686
(V-set) 		4 THR A  73
SER A  62
THR A  71
SER A  64
 None
 1.03A 5l4eA-4ouoA:
undetectable
5l4eB-4ouoA:
undetectable
5l4eC-4ouoA:
undetectable
5l4eD-4ouoA:
undetectable
5l4eE-4ouoA:
undetectable		 5l4eA-4ouoA:
20.60
5l4eB-4ouoA:
20.60
5l4eC-4ouoA:
20.60
5l4eD-4ouoA:
20.60
5l4eE-4ouoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59

(Homo sapiens) 		no annotation 4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.00A 5l4eA-4qf1L:
undetectable
5l4eB-4qf1L:
undetectable
5l4eC-4qf1L:
undetectable
5l4eD-4qf1L:
undetectable
5l4eE-4qf1L:
undetectable		 5l4eA-4qf1L:
21.40
5l4eB-4qf1L:
21.40
5l4eC-4qf1L:
21.40
5l4eD-4qf1L:
21.40
5l4eE-4qf1L:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 SER A 351
THR A 278
THR A 380
THR A 287
 3V5  A 502 ( 3.7A)
None
None
None
 1.02A 5l4eA-4qtfA:
undetectable
5l4eB-4qtfA:
undetectable
5l4eC-4qtfA:
undetectable
5l4eD-4qtfA:
undetectable
5l4eE-4qtfA:
undetectable		 5l4eA-4qtfA:
22.81
5l4eB-4qtfA:
22.81
5l4eC-4qtfA:
22.81
5l4eD-4qtfA:
22.81
5l4eE-4qtfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 256
THR A 289
SER A 287
THR A 499
 None
 0.98A 5l4eA-4r1dA:
undetectable
5l4eB-4r1dA:
undetectable
5l4eC-4r1dA:
undetectable
5l4eD-4r1dA:
0.6
5l4eE-4r1dA:
0.6		 5l4eA-4r1dA:
19.55
5l4eB-4r1dA:
19.55
5l4eC-4r1dA:
19.55
5l4eD-4r1dA:
19.55
5l4eE-4r1dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 120
THR A 480
THR A  31
SER A  33
 None
 0.91A 5l4eA-4rvwA:
undetectable
5l4eB-4rvwA:
undetectable
5l4eC-4rvwA:
undetectable
5l4eD-4rvwA:
undetectable
5l4eE-4rvwA:
undetectable		 5l4eA-4rvwA:
18.58
5l4eB-4rvwA:
18.58
5l4eC-4rvwA:
18.58
5l4eD-4rvwA:
18.58
5l4eE-4rvwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 THR A 272
SER A 255
THR A 261
SER A 257
 None
 1.00A 5l4eA-4wjsA:
undetectable
5l4eB-4wjsA:
undetectable
5l4eC-4wjsA:
undetectable
5l4eD-4wjsA:
undetectable
5l4eE-4wjsA:
undetectable		 5l4eA-4wjsA:
20.12
5l4eB-4wjsA:
20.12
5l4eC-4wjsA:
20.12
5l4eD-4wjsA:
20.12
5l4eE-4wjsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydv HIV ANTIBODY 7B2
LIGHT CHAIN,IG KAPPA
CHAIN C REGION

(Homo sapiens) 		no annotation 4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.95A 5l4eA-4ydvL:
undetectable
5l4eB-4ydvL:
3.1
5l4eC-4ydvL:
undetectable
5l4eD-4ydvL:
undetectable
5l4eE-4ydvL:
undetectable		 5l4eA-4ydvL:
21.41
5l4eB-4ydvL:
21.41
5l4eC-4ydvL:
21.41
5l4eD-4ydvL:
21.41
5l4eE-4ydvL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  71
SER A  64
THR A  69
SER A  66
 None
 0.86A 5l4eA-4z0xA:
undetectable
5l4eB-4z0xA:
undetectable
5l4eC-4z0xA:
undetectable
5l4eD-4z0xA:
undetectable
5l4eE-4z0xA:
undetectable		 5l4eA-4z0xA:
15.41
5l4eB-4z0xA:
15.41
5l4eC-4z0xA:
15.41
5l4eD-4z0xA:
15.41
5l4eE-4z0xA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aam SCFV513

(Mus musculus) 		PF07686
(V-set) 		4 THR A 210
SER A 199
THR A 208
SER A 201
 None
 0.93A 5l4eA-5aamA:
undetectable
5l4eB-5aamA:
undetectable
5l4eC-5aamA:
undetectable
5l4eD-5aamA:
undetectable
5l4eE-5aamA:
undetectable		 5l4eA-5aamA:
20.18
5l4eB-5aamA:
20.18
5l4eC-5aamA:
20.18
5l4eD-5aamA:
20.18
5l4eE-5aamA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  78
SER A  67
THR A  76
SER A  69
 None
 1.00A 5l4eA-5b8cA:
undetectable
5l4eB-5b8cA:
undetectable
5l4eC-5b8cA:
undetectable
5l4eD-5b8cA:
undetectable
5l4eE-5b8cA:
undetectable		 5l4eA-5b8cA:
18.33
5l4eB-5b8cA:
18.33
5l4eC-5b8cA:
18.33
5l4eD-5b8cA:
18.33
5l4eE-5b8cA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.94A 5l4eA-5dd5L:
undetectable
5l4eB-5dd5L:
undetectable
5l4eC-5dd5L:
undetectable
5l4eD-5dd5L:
undetectable
5l4eE-5dd5L:
undetectable		 5l4eA-5dd5L:
19.94
5l4eB-5dd5L:
19.94
5l4eC-5dd5L:
19.94
5l4eD-5dd5L:
19.94
5l4eE-5dd5L:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H 185
SER H 138
THR L 124
THR L 126
 None
 1.02A 5l4eA-5eorH:
undetectable
5l4eB-5eorH:
undetectable
5l4eC-5eorH:
2.5
5l4eD-5eorH:
undetectable
5l4eE-5eorH:
undetectable		 5l4eA-5eorH:
19.94
5l4eB-5eorH:
19.94
5l4eC-5eorH:
19.94
5l4eD-5eorH:
19.94
5l4eE-5eorH:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 THR B  84
SER B 123
THR B  96
SER B  99
 None
SAM  B 401 (-4.2A)
None
None
 1.03A 5l4eA-5ergB:
undetectable
5l4eB-5ergB:
undetectable
5l4eC-5ergB:
undetectable
5l4eD-5ergB:
undetectable
5l4eE-5ergB:
undetectable		 5l4eA-5ergB:
22.65
5l4eB-5ergB:
22.65
5l4eC-5ergB:
22.65
5l4eD-5ergB:
22.65
5l4eE-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  71
SER B  64
THR B  69
SER B  66
 None
 0.94A 5l4eA-5esaB:
2.5
5l4eB-5esaB:
2.5
5l4eC-5esaB:
2.5
5l4eD-5esaB:
undetectable
5l4eE-5esaB:
2.5		 5l4eA-5esaB:
21.58
5l4eB-5esaB:
21.58
5l4eC-5esaB:
21.58
5l4eD-5esaB:
21.58
5l4eE-5esaB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		4 THR A 111
SER A  93
THR A 199
SER A 163
 GGL  A 301 (-3.9A)
GGL  A 301 (-2.6A)
None
GGL  A 301 ( 4.1A)
 0.76A 5l4eA-5eyfA:
undetectable
5l4eB-5eyfA:
undetectable
5l4eC-5eyfA:
undetectable
5l4eD-5eyfA:
undetectable
5l4eE-5eyfA:
undetectable		 5l4eA-5eyfA:
24.59
5l4eB-5eyfA:
24.59
5l4eC-5eyfA:
24.59
5l4eD-5eyfA:
24.59
5l4eE-5eyfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		4 THR A 199
SER A 163
THR A 111
SER A  93
 None
GGL  A 301 ( 4.1A)
GGL  A 301 (-3.9A)
GGL  A 301 (-2.6A)
 0.75A 5l4eA-5eyfA:
undetectable
5l4eB-5eyfA:
undetectable
5l4eC-5eyfA:
undetectable
5l4eD-5eyfA:
undetectable
5l4eE-5eyfA:
undetectable		 5l4eA-5eyfA:
24.59
5l4eB-5eyfA:
24.59
5l4eC-5eyfA:
24.59
5l4eD-5eyfA:
24.59
5l4eE-5eyfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f72 SINGLE CHAIN FV FROM
A FAB

(Homo sapiens) 		no annotation 4 THR T 215
SER T 204
THR T 213
SER T 206
 None
 1.01A 5l4eA-5f72T:
undetectable
5l4eB-5f72T:
undetectable
5l4eC-5f72T:
undetectable
5l4eD-5f72T:
undetectable
5l4eE-5f72T:
undetectable		 5l4eA-5f72T:
21.25
5l4eB-5f72T:
21.25
5l4eC-5f72T:
21.25
5l4eD-5f72T:
21.25
5l4eE-5f72T:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv1 VK DOMAIN ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.94A 5l4eA-5fv1L:
undetectable
5l4eB-5fv1L:
undetectable
5l4eC-5fv1L:
undetectable
5l4eD-5fv1L:
undetectable
5l4eE-5fv1L:
undetectable		 5l4eA-5fv1L:
17.01
5l4eB-5fv1L:
17.01
5l4eC-5fv1L:
17.01
5l4eD-5fv1L:
17.01
5l4eE-5fv1L:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 THR L 195
SER L 184
THR L 193
SER L 186
 THR  L 195 ( 0.8A)
SER  L 184 ( 0.0A)
THR  L 193 ( 0.8A)
SER  L 186 ( 0.0A)
 0.97A 5l4eA-5gruL:
undetectable
5l4eB-5gruL:
2.6
5l4eC-5gruL:
undetectable
5l4eD-5gruL:
undetectable
5l4eE-5gruL:
undetectable		 5l4eA-5gruL:
20.37
5l4eB-5gruL:
20.37
5l4eC-5gruL:
20.37
5l4eD-5gruL:
20.37
5l4eE-5gruL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR K 198
SER K 187
THR K 196
SER K 189
 None
 0.98A 5l4eA-5grvK:
undetectable
5l4eB-5grvK:
undetectable
5l4eC-5grvK:
undetectable
5l4eD-5grvK:
undetectable
5l4eE-5grvK:
undetectable		 5l4eA-5grvK:
18.10
5l4eB-5grvK:
18.10
5l4eC-5grvK:
18.10
5l4eD-5grvK:
18.10
5l4eE-5grvK:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 THR C 198
SER C 187
THR C 196
SER C 189
 None
 0.99A 5l4eA-5gs1C:
undetectable
5l4eB-5gs1C:
undetectable
5l4eC-5gs1C:
undetectable
5l4eD-5gs1C:
undetectable
5l4eE-5gs1C:
undetectable		 5l4eA-5gs1C:
20.06
5l4eB-5gs1C:
20.06
5l4eC-5gs1C:
20.06
5l4eD-5gs1C:
20.06
5l4eE-5gs1C:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 THR A  75
SER A  64
THR A  73
SER A  66
 None
 0.94A 5l4eA-5gs1A:
undetectable
5l4eB-5gs1A:
undetectable
5l4eC-5gs1A:
undetectable
5l4eD-5gs1A:
undetectable
5l4eE-5gs1A:
undetectable		 5l4eA-5gs1A:
17.59
5l4eB-5gs1A:
17.59
5l4eC-5gs1A:
17.59
5l4eD-5gs1A:
17.59
5l4eE-5gs1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs3 DIABODY PROTEIN

(Homo sapiens) 		no annotation 4 THR H 198
SER H 187
THR H 196
SER H 189
 None
 0.96A 5l4eA-5gs3H:
undetectable
5l4eB-5gs3H:
undetectable
5l4eC-5gs3H:
undetectable
5l4eD-5gs3H:
undetectable
5l4eE-5gs3H:
undetectable		 5l4eA-5gs3H:
20.06
5l4eB-5gs3H:
20.06
5l4eC-5gs3H:
20.06
5l4eD-5gs3H:
20.06
5l4eE-5gs3H:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 THR B 143
SER B 108
THR B 145
SER B 110
 None
 1.02A 5l4eA-5iklB:
undetectable
5l4eB-5iklB:
undetectable
5l4eC-5iklB:
undetectable
5l4eD-5iklB:
undetectable
5l4eE-5iklB:
undetectable		 5l4eA-5iklB:
22.43
5l4eB-5iklB:
22.43
5l4eC-5iklB:
22.43
5l4eD-5iklB:
22.43
5l4eE-5iklB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 LIGHT
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.03A 5l4eA-5iltL:
undetectable
5l4eB-5iltL:
undetectable
5l4eC-5iltL:
undetectable
5l4eD-5iltL:
undetectable
5l4eE-5iltL:
undetectable		 5l4eA-5iltL:
23.13
5l4eB-5iltL:
23.13
5l4eC-5iltL:
23.13
5l4eD-5iltL:
23.13
5l4eE-5iltL:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  76
SER B  65
THR B  74
SER B  67
 None
 1.03A 5l4eA-5j13B:
2.2
5l4eB-5j13B:
2.3
5l4eC-5j13B:
2.3
5l4eD-5j13B:
2.3
5l4eE-5j13B:
2.3		 5l4eA-5j13B:
20.63
5l4eB-5j13B:
20.63
5l4eC-5j13B:
20.63
5l4eD-5j13B:
20.63
5l4eE-5j13B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 SER A 351
THR A 278
THR A 380
THR A 287
 6QR  A 503 (-3.7A)
None
None
None
 1.02A 5l4eA-5k69A:
undetectable
5l4eB-5k69A:
undetectable
5l4eC-5k69A:
undetectable
5l4eD-5k69A:
undetectable
5l4eE-5k69A:
undetectable		 5l4eA-5k69A:
22.56
5l4eB-5k69A:
22.56
5l4eC-5k69A:
22.56
5l4eD-5k69A:
22.56
5l4eE-5k69A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 THR A  49
SER A 170
SER A 207
SER A 160
 None
 1.02A 5l4eA-5k8dA:
undetectable
5l4eB-5k8dA:
undetectable
5l4eC-5k8dA:
undetectable
5l4eD-5k8dA:
undetectable
5l4eE-5k8dA:
undetectable		 5l4eA-5k8dA:
18.31
5l4eB-5k8dA:
18.31
5l4eC-5k8dA:
18.31
5l4eD-5k8dA:
18.31
5l4eE-5k8dA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 THR A  32
SER A   1
THR A 325
SER A 321
 None
 0.93A 5l4eA-5o6vA:
undetectable
5l4eB-5o6vA:
2.8
5l4eC-5o6vA:
undetectable
5l4eD-5o6vA:
undetectable
5l4eE-5o6vA:
undetectable		 5l4eA-5o6vA:
14.18
5l4eB-5o6vA:
14.18
5l4eC-5o6vA:
14.18
5l4eD-5o6vA:
14.18
5l4eE-5o6vA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 THR A 325
SER A 321
THR A  32
SER A   1
 None
 0.93A 5l4eA-5o6vA:
undetectable
5l4eB-5o6vA:
2.8
5l4eC-5o6vA:
undetectable
5l4eD-5o6vA:
undetectable
5l4eE-5o6vA:
undetectable		 5l4eA-5o6vA:
14.18
5l4eB-5o6vA:
14.18
5l4eC-5o6vA:
14.18
5l4eD-5o6vA:
14.18
5l4eE-5o6vA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ock HUMAN ACPA E4 FAB
FRAGMENT - LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 THR L  73
SER L  66
THR L  71
SER L  68
 None
 0.94A 5l4eA-5ockL:
3.4
5l4eB-5ockL:
3.3
5l4eC-5ockL:
3.3
5l4eD-5ockL:
undetectable
5l4eE-5ockL:
3.3		 5l4eA-5ockL:
13.38
5l4eB-5ockL:
13.38
5l4eC-5ockL:
13.38
5l4eD-5ockL:
13.38
5l4eE-5ockL:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 4 THR L  73
SER L  66
THR L  71
SER L  68
 None
 1.02A 5l4eA-5ocyL:
undetectable
5l4eB-5ocyL:
undetectable
5l4eC-5ocyL:
undetectable
5l4eD-5ocyL:
undetectable
5l4eE-5ocyL:
undetectable		 5l4eA-5ocyL:
13.38
5l4eB-5ocyL:
13.38
5l4eC-5ocyL:
13.38
5l4eD-5ocyL:
13.38
5l4eE-5ocyL:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 THR B  18
SER B  76
SER B  63
THR B  72
SER B  65
 None
 1.47A 5l4eA-5odbB:
undetectable
5l4eB-5odbB:
undetectable
5l4eC-5odbB:
undetectable
5l4eD-5odbB:
undetectable
5l4eE-5odbB:
undetectable		 5l4eA-5odbB:
14.39
5l4eB-5odbB:
14.39
5l4eC-5odbB:
14.39
5l4eD-5odbB:
14.39
5l4eE-5odbB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3k DH511.2 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.97A 5l4eA-5u3kL:
undetectable
5l4eB-5u3kL:
undetectable
5l4eC-5u3kL:
undetectable
5l4eD-5u3kL:
3.2
5l4eE-5u3kL:
undetectable		 5l4eA-5u3kL:
20.97
5l4eB-5u3kL:
20.97
5l4eC-5u3kL:
20.97
5l4eD-5u3kL:
20.97
5l4eE-5u3kL:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3n DH511.12P FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.00A 5l4eA-5u3nL:
undetectable
5l4eB-5u3nL:
undetectable
5l4eC-5u3nL:
undetectable
5l4eD-5u3nL:
3.3
5l4eE-5u3nL:
undetectable		 5l4eA-5u3nL:
22.54
5l4eB-5u3nL:
22.54
5l4eC-5u3nL:
22.54
5l4eD-5u3nL:
22.54
5l4eE-5u3nL:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwv L,D-TRANSPEPTIDASE 2

(Mycobacteroides
abscessus) 		no annotation 4 SER B 348
THR B 275
THR B 377
THR B 284
 None
 1.01A 5l4eA-5uwvB:
undetectable
5l4eB-5uwvB:
undetectable
5l4eC-5uwvB:
undetectable
5l4eD-5uwvB:
undetectable
5l4eE-5uwvB:
undetectable		 5l4eA-5uwvB:
24.74
5l4eB-5uwvB:
24.74
5l4eC-5uwvB:
24.74
5l4eD-5uwvB:
24.74
5l4eE-5uwvB:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj3 IPILIMUMAB-VL

(Homo sapiens) 		no annotation 4 THR B  75
SER B  64
THR B  73
SER B  66
 None
 0.96A 5l4eA-5xj3B:
undetectable
5l4eB-5xj3B:
undetectable
5l4eC-5xj3B:
undetectable
5l4eD-5xj3B:
undetectable
5l4eE-5xj3B:
undetectable		 5l4eA-5xj3B:
18.11
5l4eB-5xj3B:
18.11
5l4eC-5xj3B:
18.11
5l4eD-5xj3B:
18.11
5l4eE-5xj3B:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 4 THR L  78
SER L  67
THR L  76
SER L  69
 None
 1.00A 5l4eA-6aq7L:
3.3
5l4eB-6aq7L:
undetectable
5l4eC-6aq7L:
undetectable
5l4eD-6aq7L:
3.3
5l4eE-6aq7L:
3.3		 5l4eA-6aq7L:
11.73
5l4eB-6aq7L:
11.73
5l4eC-6aq7L:
11.73
5l4eD-6aq7L:
11.73
5l4eE-6aq7L:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 THR A 181
SER A  99
THR A 179
SER A 101
 None
 0.92A 5l4eA-6begA:
undetectable
5l4eB-6begA:
undetectable
5l4eC-6begA:
undetectable
5l4eD-6begA:
undetectable
5l4eE-6begA:
undetectable		 5l4eA-6begA:
undetectable
5l4eB-6begA:
undetectable
5l4eC-6begA:
undetectable
5l4eD-6begA:
undetectable
5l4eE-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 4 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.90A 5l4eA-6cjkA:
undetectable
5l4eB-6cjkA:
undetectable
5l4eC-6cjkA:
undetectable
5l4eD-6cjkA:
undetectable
5l4eE-6cjkA:
undetectable		 5l4eA-6cjkA:
undetectable
5l4eB-6cjkA:
undetectable
5l4eC-6cjkA:
undetectable
5l4eD-6cjkA:
undetectable
5l4eE-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 4 SER C 158
THR C 162
THR C 206
SER C 204
 None
 0.99A 5l4eA-6dw1C:
19.9
5l4eB-6dw1C:
19.9
5l4eC-6dw1C:
19.9
5l4eD-6dw1C:
19.9
5l4eE-6dw1C:
19.8		 5l4eA-6dw1C:
undetectable
5l4eB-6dw1C:
undetectable
5l4eC-6dw1C:
undetectable
5l4eD-6dw1C:
undetectable
5l4eE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 4 THR B 210
SER B 199
THR B 208
SER B 201
 None
 0.99A 5l4eA-6ehxB:
undetectable
5l4eB-6ehxB:
undetectable
5l4eC-6ehxB:
undetectable
5l4eD-6ehxB:
undetectable
5l4eE-6ehxB:
undetectable		 5l4eA-6ehxB:
18.58
5l4eB-6ehxB:
18.58
5l4eC-6ehxB:
18.58
5l4eD-6ehxB:
18.58
5l4eE-6ehxB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g8r SHORT-CHAIN VARIABLE
FRAGMENT

(Homo sapiens) 		no annotation 4 THR A 208
SER A 197
THR A 206
SER A 199
 None
 0.98A 5l4eA-6g8rA:
2.2
5l4eB-6g8rA:
undetectable
5l4eC-6g8rA:
undetectable
5l4eD-6g8rA:
undetectable
5l4eE-6g8rA:
undetectable		 5l4eA-6g8rA:
16.39
5l4eB-6g8rA:
16.39
5l4eC-6g8rA:
16.39
5l4eD-6g8rA:
16.39
5l4eE-6g8rA:
16.39