SIMILAR PATTERNS OF AMINO ACIDS FOR 5L2T_A_6ZZA900_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		3 LYS A  67
GLN A 110
ASN A 108
 None
 1.00A 5l2tA-1cemA:
0.0		 5l2tA-1cemA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		3 LYS A 142
GLN A  97
ASN A 101
 None
 0.86A 5l2tA-1d5cA:
undetectable		 5l2tA-1d5cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		3 LYS A 253
GLN A 244
ASN A 247
 None
 0.88A 5l2tA-1e4oA:
0.0		 5l2tA-1e4oA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		3 LYS A 203
GLN A 156
ASN A 149
 PLP  A 500 (-2.4A)
None
None
 0.94A 5l2tA-1ecxA:
0.0		 5l2tA-1ecxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LYS A 194
GLN A  20
ASN A  21
 None
 0.93A 5l2tA-1h17A:
0.0		 5l2tA-1h17A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1it2 HEMOGLOBIN

(Eptatretus
burgeri) 		PF00042
(Globin) 		3 LYS A  78
GLN A  89
ASN A  88
 LYS  A  78 (-0.0A)
GLN  A  89 ( 0.6A)
ASN  A  88 ( 0.6A)
 0.99A 5l2tA-1it2A:
undetectable		 5l2tA-1it2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		3 LYS A  17
GLN A  89
ASN A  87
 None
 1.05A 5l2tA-1j5wA:
undetectable		 5l2tA-1j5wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 LYS A 440
GLN A 413
ASN A 412
 None
 0.95A 5l2tA-1jaeA:
undetectable		 5l2tA-1jaeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1
BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00097
(zf-C3HC4)
PF14835
(zf-RING_6) 		3 LYS B 110
GLN A  19
ASN A  16
 None
 0.96A 5l2tA-1jm7B:
undetectable		 5l2tA-1jm7B:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 585
GLN A 294
ASN A 288
 None
 1.06A 5l2tA-1loxA:
0.0		 5l2tA-1loxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 323
GLN H 296
ASN H 297
 None
 0.84A 5l2tA-1mcoH:
undetectable		 5l2tA-1mcoH:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nze OXYGEN-EVOLVING
ENHANCER PROTEIN 3

(Spinacia
oleracea) 		PF05757
(PsbQ) 		3 LYS A  38
GLN A  75
ASN A  76
 None
 0.91A 5l2tA-1nzeA:
undetectable		 5l2tA-1nzeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		3 LYS A 526
GLN A  85
ASN A  83
 None
 1.07A 5l2tA-1pixA:
0.8		 5l2tA-1pixA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 LYS A 147
GLN A 128
ASN A 129
 None
 1.09A 5l2tA-1qgjA:
undetectable		 5l2tA-1qgjA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 LYS A1194
GLN A1020
ASN A1021
 None
 0.98A 5l2tA-1qhmA:
undetectable		 5l2tA-1qhmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 LYS A 611
GLN A 135
ASN A  62
 None
 1.03A 5l2tA-1qu2A:
undetectable		 5l2tA-1qu2A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		3 LYS A  76
GLN A  57
ASN A  39
 None
 0.83A 5l2tA-1rw2A:
undetectable		 5l2tA-1rw2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 LYS A  87
GLN A  13
ASN A  23
 None
CA  A1292 (-3.4A)
None
 1.03A 5l2tA-1s2nA:
undetectable		 5l2tA-1s2nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfx TISSUE FACTOR
PATHWAY INHIBITOR

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 LYS C   1
GLN C  26
ASN C  24
 None
 1.08A 5l2tA-1tfxC:
undetectable		 5l2tA-1tfxC:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A 151
GLN A 144
ASN A 145
 None
 0.75A 5l2tA-1tt7A:
undetectable		 5l2tA-1tt7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		3 LYS A  28
GLN A  70
ASN A  69
 None
 1.08A 5l2tA-1xszA:
undetectable		 5l2tA-1xszA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A  73
GLN A 108
ASN A 109
 None
 1.07A 5l2tA-1y6jA:
undetectable		 5l2tA-1y6jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2a TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF11474
(N-Term_TEN) 		3 LYS A  13
GLN A 176
ASN A 175
 None
 0.91A 5l2tA-2b2aA:
undetectable		 5l2tA-2b2aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 LYS A 114
GLN A 178
ASN A 182
 None
 0.94A 5l2tA-2cw2A:
undetectable		 5l2tA-2cw2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LYS A  64
GLN A 598
ASN A 597
 None
 1.03A 5l2tA-2inyA:
undetectable		 5l2tA-2inyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2li6 SWI/SNF
CHROMATIN-REMODELING
COMPLEX SUBUNIT SWI1

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		3 LYS A  25
GLN A  39
ASN A   4
 None
 0.73A 5l2tA-2li6A:
undetectable		 5l2tA-2li6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 LYS A 854
GLN A 206
ASN A 771
 None
 0.99A 5l2tA-2np0A:
undetectable		 5l2tA-2np0A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0i C PROTEIN
ALPHA-ANTIGEN

(Streptococcus
agalactiae) 		PF08829
(AlphaC_N)
PF17480
(AlphaC_C) 		3 LYS 1  57
GLN 1  75
ASN 1  78
 None
 0.84A 5l2tA-2o0i1:
undetectable		 5l2tA-2o0i1:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		3 LYS A 436
GLN A 425
ASN A 422
 None
 0.82A 5l2tA-2obmA:
undetectable		 5l2tA-2obmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN
INTERCELLULAR
ADHESION MOLECULE 1

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 LYS H  99
GLN A 436
ASN A 397
 None
 0.71A 5l2tA-2oz4H:
undetectable		 5l2tA-2oz4H:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A 362
GLN A 354
ASN A 355
 None
SO4  A2006 (-4.5A)
SO4  A2006 (-3.2A)
 1.05A 5l2tA-2q27A:
undetectable		 5l2tA-2q27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LYS A 329
GLN A 183
ASN A 237
 None
 1.01A 5l2tA-2qn0A:
undetectable		 5l2tA-2qn0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		3 LYS A 566
GLN A 617
ASN A 638
 None
 1.09A 5l2tA-2qv3A:
undetectable		 5l2tA-2qv3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		3 LYS A  22
GLN A 102
ASN A  99
 GDP  A3800 (-2.6A)
None
MG  A1002 ( 4.7A)
 0.77A 5l2tA-2rhdA:
undetectable		 5l2tA-2rhdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 LYS A  77
GLN A 500
ASN A 501
 None
 0.92A 5l2tA-2wsxA:
undetectable		 5l2tA-2wsxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 LYS A 632
GLN A 678
ASN A 677
 None
 0.92A 5l2tA-2yiaA:
undetectable		 5l2tA-2yiaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 LYS D 632
GLN D 678
ASN D 677
 None
 0.95A 5l2tA-2yibD:
undetectable		 5l2tA-2yibD:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 217
GLN A 583
ASN A 242
 None
 1.00A 5l2tA-3bmwA:
undetectable		 5l2tA-3bmwA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 LYS A 658
GLN A 826
ASN A 829
 None
 1.06A 5l2tA-3c10A:
undetectable		 5l2tA-3c10A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 LYS A 272
GLN A 333
ASN A 330
 None
 1.03A 5l2tA-3c7kA:
1.2		 5l2tA-3c7kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 302 (-2.6A)
None
None
 0.78A 5l2tA-3cphA:
undetectable		 5l2tA-3cphA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		3 LYS A 208
GLN A 300
ASN A 303
 None
 0.93A 5l2tA-3gseA:
undetectable		 5l2tA-3gseA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 LYS A 164
GLN A 170
ASN A 172
 None
 1.08A 5l2tA-3gt5A:
undetectable		 5l2tA-3gt5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LYS C  54
GLN C 104
ASN C 107
 None
 0.97A 5l2tA-3hrdC:
undetectable		 5l2tA-3hrdC:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		3 LYS A 322
GLN A 360
ASN A 381
 None
 0.97A 5l2tA-3iiwA:
undetectable		 5l2tA-3iiwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwb S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Thermotoga
maritima) 		PF02675
(AdoMet_dc) 		3 LYS A 101
GLN B  24
ASN B  22
 None
 1.08A 5l2tA-3iwbA:
undetectable		 5l2tA-3iwbA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		PF16522
(FliS_cochap) 		3 LYS A  56
GLN A  87
ASN A  85
 None
 1.07A 5l2tA-3k1hA:
undetectable		 5l2tA-3k1hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 LYS A 534
GLN A 500
ASN A 502
 None
 0.96A 5l2tA-3ksyA:
undetectable		 5l2tA-3ksyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  62
GLN A 162
ASN A 163
 QUE  A   1 (-4.1A)
None
None
 0.81A 5l2tA-3lm5A:
11.1		 5l2tA-3lm5A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		3 LYS A  61
GLN A  29
ASN A  30
 None
 0.91A 5l2tA-3of5A:
undetectable		 5l2tA-3of5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		3 LYS A 304
GLN A 152
ASN A 153
 None
 1.08A 5l2tA-3ohnA:
undetectable		 5l2tA-3ohnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		3 LYS A 253
GLN A 244
ASN A 248
 PEG  A 264 (-4.8A)
None
None
 0.97A 5l2tA-3p8kA:
undetectable		 5l2tA-3p8kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		3 LYS A  27
GLN A 419
ASN A 490
 None
 0.98A 5l2tA-3qkiA:
undetectable		 5l2tA-3qkiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		3 LYS A 167
GLN A 373
ASN A 369
 None
 1.04A 5l2tA-3qufA:
undetectable		 5l2tA-3qufA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh0 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		3 LYS A  24
GLN A 118
ASN A 121
 None
 1.04A 5l2tA-3rh0A:
undetectable		 5l2tA-3rh0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 LYS A  41
GLN A  48
ASN A  47
 None
 1.06A 5l2tA-3s29A:
undetectable		 5l2tA-3s29A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 LYS A 213
GLN A 601
ASN A 602
 None
 0.87A 5l2tA-3szeA:
undetectable		 5l2tA-3szeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		3 LYS A 676
GLN A 568
ASN A 545
 None
 0.95A 5l2tA-3ubhA:
undetectable		 5l2tA-3ubhA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujm RASPUTIN

(Drosophila
melanogaster) 		PF02136
(NTF2) 		3 LYS A  51
GLN A  64
ASN A  61
 None
 0.94A 5l2tA-3ujmA:
undetectable		 5l2tA-3ujmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 LYS A 291
GLN A 283
ASN A 288
 SEP  A 290 ( 3.0A)
None
None
 0.90A 5l2tA-3ulzA:
4.4		 5l2tA-3ulzA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 LYS A 281
GLN A 310
ASN A 313
 None
 0.84A 5l2tA-3uszA:
undetectable		 5l2tA-3uszA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 LYS A 254
GLN A 283
ASN A 282
 None
 1.02A 5l2tA-4aplA:
undetectable		 5l2tA-4aplA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		3 LYS A  28
GLN A  70
ASN A  69
 None
None
GOL  A1350 (-2.7A)
 1.01A 5l2tA-4d7qA:
undetectable		 5l2tA-4d7qA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  43
GLN A 149
ASN A 150
 0RS  A 900 (-3.3A)
None
None
 1.08A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 LYS A 266
GLN A 315
ASN A 316
 None
 1.08A 5l2tA-4g3tA:
undetectable		 5l2tA-4g3tA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		3 LYS A 409
GLN A 305
ASN A 352
 None
 0.98A 5l2tA-4hu8A:
undetectable		 5l2tA-4hu8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		3 LYS B  24
GLN B 104
ASN B 101
 GDP  B 400 ( 2.6A)
None
None
 0.68A 5l2tA-4jvsB:
undetectable		 5l2tA-4jvsB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		3 LYS A 160
GLN A 137
ASN A 134
 None
 0.84A 5l2tA-4kmaA:
undetectable		 5l2tA-4kmaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 246
GLN A  44
ASN A  45
 None
P6G  A 305 (-3.5A)
None
 0.86A 5l2tA-4kptA:
undetectable		 5l2tA-4kptA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 478
GLN A 276
ASN A 277
 None
 0.81A 5l2tA-4kr5A:
undetectable		 5l2tA-4kr5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kso CIRCADIAN CLOCK
PROTEIN KAIB

(Synechococcus
elongatus) 		no annotation 3 LYS C  42
GLN C  51
ASN C  49
 None
 1.08A 5l2tA-4ksoC:
undetectable		 5l2tA-4ksoC:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		3 LYS A  74
GLN A  65
ASN A  66
 None
 1.07A 5l2tA-4ou2A:
undetectable		 5l2tA-4ou2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		3 LYS A  35
GLN A 110
ASN A 111
 None
 1.02A 5l2tA-4pbxA:
undetectable		 5l2tA-4pbxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsw HOPA1

(Pseudomonas
syringae) 		no annotation 3 LYS A 220
GLN A 175
ASN A 179
 None
 0.86A 5l2tA-4rswA:
undetectable		 5l2tA-4rswA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A  15
GLN A 512
ASN A 513
 None
 0.57A 5l2tA-4tnbA:
19.8		 5l2tA-4tnbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 LYS A 255
GLN A 522
ASN A 291
 None
 0.99A 5l2tA-4uooA:
undetectable		 5l2tA-4uooA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8k CAS1 PROTEIN

(Vibrio phage
ICP1) 		PF01867
(Cas_Cas1) 		3 LYS A 113
GLN A 102
ASN A 103
 None
 1.05A 5l2tA-4w8kA:
undetectable		 5l2tA-4w8kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 201 (-2.7A)
None
None
 0.79A 5l2tA-4z8yA:
undetectable		 5l2tA-4z8yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 564
GLN A 551
ASN A 384
 None
None
NAG  A1501 ( 1.9A)
 1.04A 5l2tA-5a7mA:
undetectable		 5l2tA-5a7mA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LYS A 304
GLN A 552
ASN A 508
 None
 1.07A 5l2tA-5brqA:
undetectable		 5l2tA-5brqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		3 LYS O 312
GLN O 344
ASN O 348
 None
 1.01A 5l2tA-5crjO:
undetectable		 5l2tA-5crjO:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezn CYSTEINE-RICH
PROTECTIVE ANTIGEN

(Plasmodium
falciparum) 		no annotation 3 LYS G 234
GLN G 338
ASN G 287
 None
 0.73A 5l2tA-5eznG:
undetectable		 5l2tA-5eznG:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		3 LYS A 311
GLN A  66
ASN A  64
 None
 0.97A 5l2tA-5f7vA:
undetectable		 5l2tA-5f7vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		3 LYS A  84
GLN A  39
ASN A  38
 None
5VT  A 302 (-4.4A)
None
 1.08A 5l2tA-5fahA:
undetectable		 5l2tA-5fahA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		3 LYS B 101
GLN B 454
ASN B 405
 None
 1.09A 5l2tA-5fn3B:
undetectable		 5l2tA-5fn3B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		3 LYS C 298
GLN C 357
ASN C 359
 None
 1.02A 5l2tA-5fttC:
undetectable		 5l2tA-5fttC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyd MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 254
GLN A  29
ASN A  30
 None
 1.06A 5l2tA-5gydA:
undetectable		 5l2tA-5gydA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		3 LYS A 330
GLN A 255
ASN A 258
 None
 1.06A 5l2tA-5h11A:
undetectable		 5l2tA-5h11A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 LYS A 228
GLN A  47
ASN A 144
 None
 1.04A 5l2tA-5kn8A:
undetectable		 5l2tA-5kn8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		3 LYS A 306
GLN A 441
ASN A 445
 None
 1.07A 5l2tA-5kztA:
undetectable		 5l2tA-5kztA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C) 		3 LYS N  58
GLN K  91
ASN K  92
 None
 0.97A 5l2tA-5lc5N:
undetectable		 5l2tA-5lc5N:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		3 LYS A   3
GLN A  71
ASN A  70
 None
NA  A 506 ( 3.1A)
None
 1.01A 5l2tA-5mb4A:
undetectable		 5l2tA-5mb4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG

(Homo sapiens) 		PF04821
(TIMELESS) 		3 LYS A 441
GLN A 229
ASN A 230
 None
 1.08A 5l2tA-5mqiA:
undetectable		 5l2tA-5mqiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4k NUCLEOPROTEIN

(Human
coronavirus
NL63) 		PF00937
(Corona_nucleoca) 		3 LYS A  14
GLN A 120
ASN A 119
 SO4  A 401 (-2.6A)
None
None
 1.06A 5l2tA-5n4kA:
undetectable		 5l2tA-5n4kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 LYS A 210
GLN A 285
ASN A 323
 None
 1.04A 5l2tA-5nijA:
undetectable		 5l2tA-5nijA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 3 LYS B 327
GLN B 268
ASN B 423
 None
 1.02A 5l2tA-5ovnB:
undetectable		 5l2tA-5ovnB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 3 LYS A 208
GLN A 201
ASN A 202
 None
 0.66A 5l2tA-5ttaA:
undetectable		 5l2tA-5ttaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 3 LYS A 349
GLN A 341
ASN A 308
 None
 1.06A 5l2tA-6bgdA:
undetectable		 5l2tA-6bgdA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 LYS A 200
GLN A 339
ASN A 340
 None
 0.87A 5l2tA-6bk5A:
undetectable		 5l2tA-6bk5A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A2257
GLN A1376
ASN A1374
 None
 0.97A 5l2tA-6emkA:
1.4		 5l2tA-6emkA:
16.00