SIMILAR PATTERNS OF AMINO ACIDS FOR 5L2T_A_6ZZA900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
ALA A 143
 None
 0.70A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
 None
 0.90A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
 None
 0.79A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ALA A 143
 None
 0.67A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 580
GLY A 581
VAL A 588
ALA A 606
VAL A 638
PHE A 654
ASP A 661
LEU A 731
ALA A 741
 None
 0.87A 5l2tA-1lufA:
7.1		 5l2tA-1lufA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 638
PHE A 654
ASP A 661
LEU A 731
ALA A 741
ASP A 742
 None
 0.83A 5l2tA-1lufA:
7.1		 5l2tA-1lufA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
 0.86A 5l2tA-1rjbA:
6.6		 5l2tA-1rjbA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 370
VAL A 377
ALA A 389
VAL A 419
PHE A 435
LEU A 489
 None
 0.86A 5l2tA-1snxA:
8.5		 5l2tA-1snxA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASP A 677
LEU A 799
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
 0.89A 5l2tA-1t46A:
22.1		 5l2tA-1t46A:
26.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ALA A  30
VAL A  63
PHE A  79
HIS A  81
ASP A  85
LEU A 132
ASP A 143
 None
 1.08A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 GLY A  11
ALA A  30
VAL A  63
PHE A  79
HIS A  81
ASP A  85
LEU A 132
ALA A 142
 None
 0.67A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
ALA A  30
VAL A  63
PHE A  79
HIS A  81
LEU A 132
ALA A 142
 None
 0.74A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 ILE A  10
GLY A  11
ALA A  30
VAL A  63
PHE A  79
HIS A  81
ASP A  85
LEU A 132
 None
 1.06A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 ILE A  10
GLY A  11
VAL A  18
ALA A  30
VAL A  63
PHE A  79
HIS A  81
LEU A 132
 None
 1.05A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  30
VAL A  63
PHE A  79
HIS A  81
LEU A 132
ASP A 143
 None
 1.21A 5l2tA-1v0bA:
17.5		 5l2tA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
VAL A 220
PHE A 236
LEU A 290
ALA A 319
ASP A 320
 None
 0.83A 5l2tA-2eu9A:
11.7		 5l2tA-2eu9A:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 163
VAL A 170
ALA A 184
VAL A 220
PHE A 236
LEU A 290
ALA A 319
 None
 0.83A 5l2tA-2eu9A:
11.7		 5l2tA-2eu9A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 249
VAL A 256
ALA A 269
VAL A 299
LEU A 370
ALA A 380
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.74A 5l2tA-2hz0A:
23.2		 5l2tA-2hz0A:
25.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
 None
 0.80A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
ASP A 145
 None
 0.93A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  11
VAL A  18
ALA A  31
PHE A  80
ASP A  86
LEU A 134
 None
 1.03A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
VAL A 484
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.2A)
 0.97A 5l2tA-2jkmA:
10.4		 5l2tA-2jkmA:
26.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  21
ALA A  34
VAL A  66
PHE A  82
ASP A  88
LEU A 140
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
None
 0.91A 5l2tA-2pmiA:
14.5		 5l2tA-2pmiA:
41.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
ALA A 215
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.92A 5l2tA-2v55A:
7.5		 5l2tA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 1.21A 5l2tA-2v55A:
7.5		 5l2tA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  85
ALA A  98
ASP A 155
THR A 158
LEU A 202
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
None
None
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.79A 5l2tA-2vd5A:
5.3		 5l2tA-2vd5A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY B  13
ALA B  33
VAL B  72
PHE B  93
HIS B  95
ASP B  99
THR B 102
LEU B 147
ALA B 157
 None
 0.72A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  13
HIS B  95
ASP B  99
THR B 102
LEU B 147
ALA B 157
ASP B 158
 None
 1.07A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  15
ALA B  33
VAL B  72
PHE B  93
ASP B  99
LEU B 147
ALA B 157
 None
 1.45A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		10 ILE B  12
GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
HIS B  95
THR B 102
LEU B 147
ALA B 157
 None
 0.93A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE B  12
GLY B  13
VAL B  20
HIS B  95
THR B 102
LEU B 147
ALA B 157
ASP B 158
 None
 1.29A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
 0.87A 5l2tA-2z7rA:
8.7		 5l2tA-2z7rA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.77A 5l2tA-3bhhA:
7.4		 5l2tA-3bhhA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
 3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
 1.12A 5l2tA-3c0iA:
7.8		 5l2tA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  23
GLY A  24
VAL A  31
ALA A  44
VAL A  76
LEU A 153
ALA A 163
 ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
 0.93A 5l2tA-3dakA:
22.1		 5l2tA-3dakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.94A 5l2tA-3f2aA:
7.8		 5l2tA-3f2aA:
26.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A  25
GLY A  26
VAL A  33
ALA A  46
VAL A  79
PHE A 103
ASP A 109
LEU A 156
ALA A 166
 None
 0.83A 5l2tA-3mi9A:
12.9		 5l2tA-3mi9A:
36.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  79
PHE A 103
ASP A 109
LEU A 156
ALA A 166
ASP A 167
 None
 0.73A 5l2tA-3mi9A:
12.9		 5l2tA-3mi9A:
36.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 172
VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.85A 5l2tA-3mtlA:
18.2		 5l2tA-3mtlA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
ALA A 303
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.87A 5l2tA-3mtlA:
18.2		 5l2tA-3mtlA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  25
ALA A  38
VAL A  72
PHE A  90
ASP A  96
LEU A 141
ALA A 151
 None
 0.91A 5l2tA-3oz6A:
14.3		 5l2tA-3oz6A:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
ALA A 217
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.80A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ASP A 160
THR A 163
LEU A 207
ALA A 217
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.89A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
 1.10A 5l2tA-3qfvA:
6.8		 5l2tA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 362
VAL A 369
ALA A 382
ASP A 440
LEU A 486
ALA A 496
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.86A 5l2tA-3txoA:
19.9		 5l2tA-3txoA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
VAL A 601
PHE A 617
ASP A 624
LEU A 686
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.86A 5l2tA-3v5qA:
21.9		 5l2tA-3v5qA:
27.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  76
VAL A  83
ALA A  96
VAL A 128
HIS A 146
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.9A)
ANP  A 401 (-4.8A)
 0.87A 5l2tA-3wigA:
7.2		 5l2tA-3wigA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 ( 4.3A)
D15  A 500 (-4.5A)
 0.75A 5l2tA-4aguA:
17.1		 5l2tA-4aguA:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 568
ALA A 586
VAL A 617
PHE A 633
ASP A 640
LEU A 699
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
 0.86A 5l2tA-4at3A:
6.8		 5l2tA-4at3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A  84
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.95A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A  84
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.94A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A  83
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
 0.98A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.73A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.78A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 5l2tA-4bbmA:
13.9		 5l2tA-4bbmA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  43
VAL A  50
ALA A  63
VAL A  94
LEU A 164
ALA A 174
 XZN  A1317 ( 4.9A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.93A 5l2tA-4bc6A:
20.7		 5l2tA-4bc6A:
28.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.68A 5l2tA-4bgqA:
17.1		 5l2tA-4bgqA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.74A 5l2tA-4crsA:
8.0		 5l2tA-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.86A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
GLY A 568
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
VAL A  77
PHE A  98
ASP A 104
THR A 106
LEU A 152
 None
None
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
 1.44A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		12 ILE A  19
GLY A  20
VAL A  27
ALA A  41
VAL A  77
PHE A  98
HIS A 100
ASP A 104
THR A 107
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.1A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.66A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 516
VAL A 523
ALA A 541
VAL A 572
PHE A 588
ASP A 595
LEU A 656
 None
 0.91A 5l2tA-4f0iA:
21.9		 5l2tA-4f0iA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1123
VAL A1130
ALA A1148
VAL A1180
ASP A1203
LEU A1256
 0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
 0.94A 5l2tA-4fodA:
7.5		 5l2tA-4fodA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE B  30
GLY B  31
VAL B  38
ALA B  51
LEU B 151
ALA B 161
 GOL  B1000 (-4.1A)
None
None
GOL  B1000 ( 4.3A)
GOL  B1000 ( 4.4A)
None
 0.64A 5l2tA-4fzdB:
23.8		 5l2tA-4fzdB:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
VAL A 836
ALA A 853
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.83A 5l2tA-4hviA:
23.1		 5l2tA-4hviA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
ASP A 764
 None
 0.93A 5l2tA-4otdA:
7.3		 5l2tA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
P30  A1001 (-4.6A)
 0.81A 5l2tA-4rt7A:
6.8		 5l2tA-4rt7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.3A)
 0.76A 5l2tA-4xufA:
7.0		 5l2tA-4xufA:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 135
ALA A 145
 None
 0.88A 5l2tA-4yc6A:
14.8		 5l2tA-4yc6A:
45.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
VAL A  64
ASP A  86
LEU A 135
ALA A 145
ASP A 146
 None
 0.98A 5l2tA-4yc6A:
14.8		 5l2tA-4yc6A:
45.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 135
ALA A 145
 None
 0.69A 5l2tA-4yc6A:
14.8		 5l2tA-4yc6A:
45.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 470
VAL A 477
ALA A 488
LEU A 595
ALA A 605
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
 0.71A 5l2tA-4yffA:
21.3		 5l2tA-4yffA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 165
GLY A 166
VAL A 173
ALA A 186
PHE A 238
LEU A 294
 4E1  A 505 ( 4.6A)
4E1  A 505 (-3.5A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
4E1  A 505 (-4.2A)
None
 0.83A 5l2tA-4yljA:
12.8		 5l2tA-4yljA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 165
GLY A 166
VAL A 173
ALA A 186
VAL A 222
PHE A 238
 4E1  A 505 ( 4.6A)
4E1  A 505 (-3.5A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
4E1  A 505 (-4.2A)
 0.88A 5l2tA-4yljA:
12.8		 5l2tA-4yljA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  27
VAL A  34
ALA A  47
HIS A  98
LEU A 149
ALA A 159
 None
 0.97A 5l2tA-4ynzA:
12.2		 5l2tA-4ynzA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  44
VAL A  76
ASP A  99
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
None
 0.69A 5l2tA-5ci7A:
8.1		 5l2tA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A  81
GLY A  82
VAL A  89
ALA A 102
VAL A 134
LEU A 211
 ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
 0.96A 5l2tA-5dbxA:
21.4		 5l2tA-5dbxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASP A 681
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.84A 5l2tA-5grnA:
6.7		 5l2tA-5grnA:
26.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 GLY A  21
VAL A  28
ALA A  41
VAL A  74
PHE A  90
ALA A 156
 ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.83A 5l2tA-5hu3A:
7.8		 5l2tA-5hu3A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
ALA A  50
PHE A  97
ASP A 103
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.83A 5l2tA-5idnA:
14.5		 5l2tA-5idnA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  50
PHE A  97
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.78A 5l2tA-5idnA:
14.5		 5l2tA-5idnA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  23
VAL A  30
ALA A  43
VAL A  74
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.94A 5l2tA-5j5tA:
20.7		 5l2tA-5j5tA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.86A 5l2tA-5j5tA:
20.7		 5l2tA-5j5tA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 396
GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 1.14A 5l2tA-5jznA:
8.0		 5l2tA-5jznA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  41
VAL A  49
ALA A  60
VAL A  94
ASP A 117
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
 0.74A 5l2tA-5lohA:
8.4		 5l2tA-5lohA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
GLY A 156
VAL A 163
ALA A 176
PHE A 228
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.9A)
 0.86A 5l2tA-5lxdA:
16.3		 5l2tA-5lxdA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  99
VAL A 106
ALA A 119
VAL A 157
PHE A 177
LEU A 232
 W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
DMS  A 717 ( 3.9A)
None
 0.94A 5l2tA-5myvA:
14.5		 5l2tA-5myvA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 ILE A 358
GLY A 359
ALA A 379
VAL A 413
ASP A 436
THR A 439
LEU A 482
 ANP  A 801 (-4.2A)
ANP  A 801 ( 4.1A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-3.4A)
None
ANP  A 801 (-4.8A)
 0.86A 5l2tA-5nclA:
7.3		 5l2tA-5nclA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
GLY A  99
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 1.13A 5l2tA-5u7qA:
7.6		 5l2tA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
VAL A 106
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 1.13A 5l2tA-5u7qA:
7.6		 5l2tA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 7 ILE A  75
GLY A  76
VAL A  83
ALA A  95
VAL A 125
LEU A 206
ALA A 216
 ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
 0.98A 5l2tA-5xd6A:
6.3		 5l2tA-5xd6A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 GLY A 734
VAL A 787
PHE A 813
ASP A 819
LEU A 866
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 0.96A 5l2tA-6b3eA:
13.4		 5l2tA-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 ILE A 733
GLY A 734
ALA A 754
VAL A 787
PHE A 813
ASP A 819
LEU A 866
ALA A 876
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 1.03A 5l2tA-6b3eA:
13.4		 5l2tA-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 ILE A 733
VAL A 741
ALA A 754
VAL A 787
PHE A 813
ASP A 819
LEU A 866
ALA A 876
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.91A 5l2tA-6b3eA:
13.4		 5l2tA-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 VAL A 179
ALA A 192
VAL A 249
PHE A 267
LEU A 319
ALA A 329
 BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
None
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.90A 5l2tA-6bqlA:
8.0		 5l2tA-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 GLY A 135
VAL A 142
ALA A 155
VAL A 212
PHE A 230
LEU A 282
ALA A 292
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.75A 5l2tA-6ccfA:
8.3		 5l2tA-6ccfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 ILE A 134
GLY A 135
VAL A 142
ALA A 155
VAL A 212
PHE A 230
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.8A)
 1.05A 5l2tA-6ccfA:
8.3		 5l2tA-6ccfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 VAL U  28
ALA U  42
VAL U  75
ASP U  98
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.86A 5l2tA-6fdyU:
7.3		 5l2tA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		3 LYS A  67
GLN A 110
ASN A 108
 None
 1.00A 5l2tA-1cemA:
0.0		 5l2tA-1cemA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		3 LYS A 142
GLN A  97
ASN A 101
 None
 0.86A 5l2tA-1d5cA:
undetectable		 5l2tA-1d5cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		3 LYS A 253
GLN A 244
ASN A 247
 None
 0.88A 5l2tA-1e4oA:
0.0		 5l2tA-1e4oA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		3 LYS A 203
GLN A 156
ASN A 149
 PLP  A 500 (-2.4A)
None
None
 0.94A 5l2tA-1ecxA:
0.0		 5l2tA-1ecxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LYS A 194
GLN A  20
ASN A  21
 None
 0.93A 5l2tA-1h17A:
0.0		 5l2tA-1h17A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1it2 HEMOGLOBIN

(Eptatretus
burgeri) 		PF00042
(Globin) 		3 LYS A  78
GLN A  89
ASN A  88
 LYS  A  78 (-0.0A)
GLN  A  89 ( 0.6A)
ASN  A  88 ( 0.6A)
 0.99A 5l2tA-1it2A:
undetectable		 5l2tA-1it2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		3 LYS A  17
GLN A  89
ASN A  87
 None
 1.05A 5l2tA-1j5wA:
undetectable		 5l2tA-1j5wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 LYS A 440
GLN A 413
ASN A 412
 None
 0.95A 5l2tA-1jaeA:
undetectable		 5l2tA-1jaeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1
BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00097
(zf-C3HC4)
PF14835
(zf-RING_6) 		3 LYS B 110
GLN A  19
ASN A  16
 None
 0.96A 5l2tA-1jm7B:
undetectable		 5l2tA-1jm7B:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 585
GLN A 294
ASN A 288
 None
 1.06A 5l2tA-1loxA:
0.0		 5l2tA-1loxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 323
GLN H 296
ASN H 297
 None
 0.84A 5l2tA-1mcoH:
undetectable		 5l2tA-1mcoH:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nze OXYGEN-EVOLVING
ENHANCER PROTEIN 3

(Spinacia
oleracea) 		PF05757
(PsbQ) 		3 LYS A  38
GLN A  75
ASN A  76
 None
 0.91A 5l2tA-1nzeA:
undetectable		 5l2tA-1nzeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		3 LYS A 526
GLN A  85
ASN A  83
 None
 1.07A 5l2tA-1pixA:
0.8		 5l2tA-1pixA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 LYS A 147
GLN A 128
ASN A 129
 None
 1.09A 5l2tA-1qgjA:
undetectable		 5l2tA-1qgjA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 LYS A1194
GLN A1020
ASN A1021
 None
 0.98A 5l2tA-1qhmA:
undetectable		 5l2tA-1qhmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 LYS A 611
GLN A 135
ASN A  62
 None
 1.03A 5l2tA-1qu2A:
undetectable		 5l2tA-1qu2A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		3 LYS A  76
GLN A  57
ASN A  39
 None
 0.83A 5l2tA-1rw2A:
undetectable		 5l2tA-1rw2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		3 LYS A  87
GLN A  13
ASN A  23
 None
CA  A1292 (-3.4A)
None
 1.03A 5l2tA-1s2nA:
undetectable		 5l2tA-1s2nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfx TISSUE FACTOR
PATHWAY INHIBITOR

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 LYS C   1
GLN C  26
ASN C  24
 None
 1.08A 5l2tA-1tfxC:
undetectable		 5l2tA-1tfxC:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A 151
GLN A 144
ASN A 145
 None
 0.75A 5l2tA-1tt7A:
undetectable		 5l2tA-1tt7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		3 LYS A  28
GLN A  70
ASN A  69
 None
 1.08A 5l2tA-1xszA:
undetectable		 5l2tA-1xszA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A  73
GLN A 108
ASN A 109
 None
 1.07A 5l2tA-1y6jA:
undetectable		 5l2tA-1y6jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2a TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF11474
(N-Term_TEN) 		3 LYS A  13
GLN A 176
ASN A 175
 None
 0.91A 5l2tA-2b2aA:
undetectable		 5l2tA-2b2aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 LYS A 114
GLN A 178
ASN A 182
 None
 0.94A 5l2tA-2cw2A:
undetectable		 5l2tA-2cw2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LYS A  64
GLN A 598
ASN A 597
 None
 1.03A 5l2tA-2inyA:
undetectable		 5l2tA-2inyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2li6 SWI/SNF
CHROMATIN-REMODELING
COMPLEX SUBUNIT SWI1

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		3 LYS A  25
GLN A  39
ASN A   4
 None
 0.73A 5l2tA-2li6A:
undetectable		 5l2tA-2li6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 LYS A 854
GLN A 206
ASN A 771
 None
 0.99A 5l2tA-2np0A:
undetectable		 5l2tA-2np0A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0i C PROTEIN
ALPHA-ANTIGEN

(Streptococcus
agalactiae) 		PF08829
(AlphaC_N)
PF17480
(AlphaC_C) 		3 LYS 1  57
GLN 1  75
ASN 1  78
 None
 0.84A 5l2tA-2o0i1:
undetectable		 5l2tA-2o0i1:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		3 LYS A 436
GLN A 425
ASN A 422
 None
 0.82A 5l2tA-2obmA:
undetectable		 5l2tA-2obmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN
INTERCELLULAR
ADHESION MOLECULE 1

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 LYS H  99
GLN A 436
ASN A 397
 None
 0.71A 5l2tA-2oz4H:
undetectable		 5l2tA-2oz4H:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A 362
GLN A 354
ASN A 355
 None
SO4  A2006 (-4.5A)
SO4  A2006 (-3.2A)
 1.05A 5l2tA-2q27A:
undetectable		 5l2tA-2q27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LYS A 329
GLN A 183
ASN A 237
 None
 1.01A 5l2tA-2qn0A:
undetectable		 5l2tA-2qn0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		3 LYS A 566
GLN A 617
ASN A 638
 None
 1.09A 5l2tA-2qv3A:
undetectable		 5l2tA-2qv3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		3 LYS A  22
GLN A 102
ASN A  99
 GDP  A3800 (-2.6A)
None
MG  A1002 ( 4.7A)
 0.77A 5l2tA-2rhdA:
undetectable		 5l2tA-2rhdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 LYS A  77
GLN A 500
ASN A 501
 None
 0.92A 5l2tA-2wsxA:
undetectable		 5l2tA-2wsxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 LYS A 632
GLN A 678
ASN A 677
 None
 0.92A 5l2tA-2yiaA:
undetectable		 5l2tA-2yiaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 LYS D 632
GLN D 678
ASN D 677
 None
 0.95A 5l2tA-2yibD:
undetectable		 5l2tA-2yibD:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 217
GLN A 583
ASN A 242
 None
 1.00A 5l2tA-3bmwA:
undetectable		 5l2tA-3bmwA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 LYS A 658
GLN A 826
ASN A 829
 None
 1.06A 5l2tA-3c10A:
undetectable		 5l2tA-3c10A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 LYS A 272
GLN A 333
ASN A 330
 None
 1.03A 5l2tA-3c7kA:
1.2		 5l2tA-3c7kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 302 (-2.6A)
None
None
 0.78A 5l2tA-3cphA:
undetectable		 5l2tA-3cphA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		3 LYS A 208
GLN A 300
ASN A 303
 None
 0.93A 5l2tA-3gseA:
undetectable		 5l2tA-3gseA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 LYS A 164
GLN A 170
ASN A 172
 None
 1.08A 5l2tA-3gt5A:
undetectable		 5l2tA-3gt5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LYS C  54
GLN C 104
ASN C 107
 None
 0.97A 5l2tA-3hrdC:
undetectable		 5l2tA-3hrdC:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		3 LYS A 322
GLN A 360
ASN A 381
 None
 0.97A 5l2tA-3iiwA:
undetectable		 5l2tA-3iiwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwb S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Thermotoga
maritima) 		PF02675
(AdoMet_dc) 		3 LYS A 101
GLN B  24
ASN B  22
 None
 1.08A 5l2tA-3iwbA:
undetectable		 5l2tA-3iwbA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		PF16522
(FliS_cochap) 		3 LYS A  56
GLN A  87
ASN A  85
 None
 1.07A 5l2tA-3k1hA:
undetectable		 5l2tA-3k1hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 LYS A 534
GLN A 500
ASN A 502
 None
 0.96A 5l2tA-3ksyA:
undetectable		 5l2tA-3ksyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  62
GLN A 162
ASN A 163
 QUE  A   1 (-4.1A)
None
None
 0.81A 5l2tA-3lm5A:
11.1		 5l2tA-3lm5A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		3 LYS A  61
GLN A  29
ASN A  30
 None
 0.91A 5l2tA-3of5A:
undetectable		 5l2tA-3of5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		3 LYS A 304
GLN A 152
ASN A 153
 None
 1.08A 5l2tA-3ohnA:
undetectable		 5l2tA-3ohnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		3 LYS A 253
GLN A 244
ASN A 248
 PEG  A 264 (-4.8A)
None
None
 0.97A 5l2tA-3p8kA:
undetectable		 5l2tA-3p8kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		3 LYS A  27
GLN A 419
ASN A 490
 None
 0.98A 5l2tA-3qkiA:
undetectable		 5l2tA-3qkiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		3 LYS A 167
GLN A 373
ASN A 369
 None
 1.04A 5l2tA-3qufA:
undetectable		 5l2tA-3qufA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh0 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		3 LYS A  24
GLN A 118
ASN A 121
 None
 1.04A 5l2tA-3rh0A:
undetectable		 5l2tA-3rh0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 LYS A  41
GLN A  48
ASN A  47
 None
 1.06A 5l2tA-3s29A:
undetectable		 5l2tA-3s29A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 LYS A 213
GLN A 601
ASN A 602
 None
 0.87A 5l2tA-3szeA:
undetectable		 5l2tA-3szeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		3 LYS A 676
GLN A 568
ASN A 545
 None
 0.95A 5l2tA-3ubhA:
undetectable		 5l2tA-3ubhA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujm RASPUTIN

(Drosophila
melanogaster) 		PF02136
(NTF2) 		3 LYS A  51
GLN A  64
ASN A  61
 None
 0.94A 5l2tA-3ujmA:
undetectable		 5l2tA-3ujmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 LYS A 291
GLN A 283
ASN A 288
 SEP  A 290 ( 3.0A)
None
None
 0.90A 5l2tA-3ulzA:
4.4		 5l2tA-3ulzA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 LYS A 281
GLN A 310
ASN A 313
 None
 0.84A 5l2tA-3uszA:
undetectable		 5l2tA-3uszA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 LYS A 254
GLN A 283
ASN A 282
 None
 1.02A 5l2tA-4aplA:
undetectable		 5l2tA-4aplA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		3 LYS A  28
GLN A  70
ASN A  69
 None
None
GOL  A1350 (-2.7A)
 1.01A 5l2tA-4d7qA:
undetectable		 5l2tA-4d7qA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  43
GLN A 149
ASN A 150
 0RS  A 900 (-3.3A)
None
None
 1.08A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 LYS A 266
GLN A 315
ASN A 316
 None
 1.08A 5l2tA-4g3tA:
undetectable		 5l2tA-4g3tA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		3 LYS A 409
GLN A 305
ASN A 352
 None
 0.98A 5l2tA-4hu8A:
undetectable		 5l2tA-4hu8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		3 LYS B  24
GLN B 104
ASN B 101
 GDP  B 400 ( 2.6A)
None
None
 0.68A 5l2tA-4jvsB:
undetectable		 5l2tA-4jvsB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		3 LYS A 160
GLN A 137
ASN A 134
 None
 0.84A 5l2tA-4kmaA:
undetectable		 5l2tA-4kmaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 246
GLN A  44
ASN A  45
 None
P6G  A 305 (-3.5A)
None
 0.86A 5l2tA-4kptA:
undetectable		 5l2tA-4kptA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 478
GLN A 276
ASN A 277
 None
 0.81A 5l2tA-4kr5A:
undetectable		 5l2tA-4kr5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kso CIRCADIAN CLOCK
PROTEIN KAIB

(Synechococcus
elongatus) 		no annotation 3 LYS C  42
GLN C  51
ASN C  49
 None
 1.08A 5l2tA-4ksoC:
undetectable		 5l2tA-4ksoC:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		3 LYS A  74
GLN A  65
ASN A  66
 None
 1.07A 5l2tA-4ou2A:
undetectable		 5l2tA-4ou2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		3 LYS A  35
GLN A 110
ASN A 111
 None
 1.02A 5l2tA-4pbxA:
undetectable		 5l2tA-4pbxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsw HOPA1

(Pseudomonas
syringae) 		no annotation 3 LYS A 220
GLN A 175
ASN A 179
 None
 0.86A 5l2tA-4rswA:
undetectable		 5l2tA-4rswA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A  15
GLN A 512
ASN A 513
 None
 0.57A 5l2tA-4tnbA:
19.8		 5l2tA-4tnbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 LYS A 255
GLN A 522
ASN A 291
 None
 0.99A 5l2tA-4uooA:
undetectable		 5l2tA-4uooA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8k CAS1 PROTEIN

(Vibrio phage
ICP1) 		PF01867
(Cas_Cas1) 		3 LYS A 113
GLN A 102
ASN A 103
 None
 1.05A 5l2tA-4w8kA:
undetectable		 5l2tA-4w8kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 201 (-2.7A)
None
None
 0.79A 5l2tA-4z8yA:
undetectable		 5l2tA-4z8yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 564
GLN A 551
ASN A 384
 None
None
NAG  A1501 ( 1.9A)
 1.04A 5l2tA-5a7mA:
undetectable		 5l2tA-5a7mA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LYS A 304
GLN A 552
ASN A 508
 None
 1.07A 5l2tA-5brqA:
undetectable		 5l2tA-5brqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		3 LYS O 312
GLN O 344
ASN O 348
 None
 1.01A 5l2tA-5crjO:
undetectable		 5l2tA-5crjO:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezn CYSTEINE-RICH
PROTECTIVE ANTIGEN

(Plasmodium
falciparum) 		no annotation 3 LYS G 234
GLN G 338
ASN G 287
 None
 0.73A 5l2tA-5eznG:
undetectable		 5l2tA-5eznG:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		3 LYS A 311
GLN A  66
ASN A  64
 None
 0.97A 5l2tA-5f7vA:
undetectable		 5l2tA-5f7vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		3 LYS A  84
GLN A  39
ASN A  38
 None
5VT  A 302 (-4.4A)
None
 1.08A 5l2tA-5fahA:
undetectable		 5l2tA-5fahA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		3 LYS B 101
GLN B 454
ASN B 405
 None
 1.09A 5l2tA-5fn3B:
undetectable		 5l2tA-5fn3B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		3 LYS C 298
GLN C 357
ASN C 359
 None
 1.02A 5l2tA-5fttC:
undetectable		 5l2tA-5fttC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyd MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 254
GLN A  29
ASN A  30
 None
 1.06A 5l2tA-5gydA:
undetectable		 5l2tA-5gydA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		3 LYS A 330
GLN A 255
ASN A 258
 None
 1.06A 5l2tA-5h11A:
undetectable		 5l2tA-5h11A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 LYS A 228
GLN A  47
ASN A 144
 None
 1.04A 5l2tA-5kn8A:
undetectable		 5l2tA-5kn8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		3 LYS A 306
GLN A 441
ASN A 445
 None
 1.07A 5l2tA-5kztA:
undetectable		 5l2tA-5kztA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C) 		3 LYS N  58
GLN K  91
ASN K  92
 None
 0.97A 5l2tA-5lc5N:
undetectable		 5l2tA-5lc5N:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		3 LYS A   3
GLN A  71
ASN A  70
 None
NA  A 506 ( 3.1A)
None
 1.01A 5l2tA-5mb4A:
undetectable		 5l2tA-5mb4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG

(Homo sapiens) 		PF04821
(TIMELESS) 		3 LYS A 441
GLN A 229
ASN A 230
 None
 1.08A 5l2tA-5mqiA:
undetectable		 5l2tA-5mqiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4k NUCLEOPROTEIN

(Human
coronavirus
NL63) 		PF00937
(Corona_nucleoca) 		3 LYS A  14
GLN A 120
ASN A 119
 SO4  A 401 (-2.6A)
None
None
 1.06A 5l2tA-5n4kA:
undetectable		 5l2tA-5n4kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 LYS A 210
GLN A 285
ASN A 323
 None
 1.04A 5l2tA-5nijA:
undetectable		 5l2tA-5nijA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 3 LYS B 327
GLN B 268
ASN B 423
 None
 1.02A 5l2tA-5ovnB:
undetectable		 5l2tA-5ovnB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tta PUTATIVE EXPORTED
PROTEIN

(Clostridioides
difficile) 		no annotation 3 LYS A 208
GLN A 201
ASN A 202
 None
 0.66A 5l2tA-5ttaA:
undetectable		 5l2tA-5ttaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 3 LYS A 349
GLN A 341
ASN A 308
 None
 1.06A 5l2tA-6bgdA:
undetectable		 5l2tA-6bgdA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 LYS A 200
GLN A 339
ASN A 340
 None
 0.87A 5l2tA-6bk5A:
undetectable		 5l2tA-6bk5A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A2257
GLN A1376
ASN A1374
 None
 0.97A 5l2tA-6emkA:
1.4		 5l2tA-6emkA:
16.00