SIMILAR PATTERNS OF AMINO ACIDS FOR 5L2I_A_LQQA900_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		4 LYS 1 407
HIS 1 270
VAL 1 272
ASN 1 411
 None
 1.48A 5l2iA-1gff1:
0.0		 5l2iA-1gff1:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		4 LYS A  50
HIS A 123
VAL A 122
ASN A  31
 None
 1.48A 5l2iA-3f81A:
0.0		 5l2iA-3f81A:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  43
HIS A 100
VAL A 101
ASN A 150
 0RS  A 900 (-3.3A)
0RS  A 900 (-4.1A)
0RS  A 900 (-4.5A)
None
 0.79A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		4 LYS A 194
HIS A 175
VAL A 171
ASN A 240
 None
 1.06A 5l2iA-4f78A:
undetectable		 5l2iA-4f78A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 LYS A 381
HIS A 190
VAL A 189
ASN A 389
 None
 1.11A 5l2iA-4jjaA:
0.0		 5l2iA-4jjaA:
21.16