SIMILAR PATTERNS OF AMINO ACIDS FOR 5L2I_A_LQQA900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
ALA A 143
 None
 0.77A 5l2iA-1h4lA:
14.2		 5l2iA-1h4lA:
45.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
GLY A 202
VAL A 209
ALA A 220
VAL A 249
LEU A 321
 None
 0.72A 5l2iA-1k9aA:
7.2		 5l2iA-1k9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 580
GLY A 581
VAL A 588
ALA A 606
VAL A 638
PHE A 654
ASP A 661
LEU A 731
 None
 0.71A 5l2iA-1lufA:
7.0		 5l2iA-1lufA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 580
VAL A 588
ALA A 606
VAL A 638
PHE A 654
ASP A 661
LEU A 731
ALA A 741
 None
 0.66A 5l2iA-1lufA:
7.0		 5l2iA-1lufA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A 165
VAL A 172
ALA A 185
PHE A 246
LEU A 301
ALA A 549
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.72A 5l2iA-1q8yA:
10.0		 5l2iA-1q8yA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
 0.60A 5l2iA-1rjbA:
6.6		 5l2iA-1rjbA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 370
VAL A 377
ALA A 389
VAL A 419
PHE A 435
LEU A 489
 None
 0.50A 5l2iA-1snxA:
8.4		 5l2iA-1snxA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASP A 677
LEU A 799
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
 0.53A 5l2iA-1t46A:
6.6		 5l2iA-1t46A:
26.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
ALA A  30
VAL A  63
PHE A  79
ASP A  85
LEU A 132
ALA A 142
 None
 0.56A 5l2iA-1v0bA:
17.2		 5l2iA-1v0bA:
45.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  11
VAL A  18
ALA A  30
VAL A  63
PHE A  79
ASP A  85
 None
 0.99A 5l2iA-1v0bA:
17.2		 5l2iA-1v0bA:
45.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  18
VAL X  25
ALA X  37
VAL X  67
LEU X 137
ALA X 147
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.46A 5l2iA-2dq7X:
7.1		 5l2iA-2dq7X:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL X  25
ALA X  37
VAL X  67
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.63A 5l2iA-2dq7X:
7.1		 5l2iA-2dq7X:
26.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 163
VAL A 170
ALA A 184
VAL A 220
PHE A 236
LEU A 290
ALA A 319
 None
 0.83A 5l2iA-2eu9A:
11.4		 5l2iA-2eu9A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 274
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ALA A 403
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.72A 5l2iA-2h8hA:
6.9		 5l2iA-2h8hA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 249
VAL A 256
ALA A 269
VAL A 299
LEU A 370
ALA A 380
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.47A 5l2iA-2hz0A:
5.9		 5l2iA-2hz0A:
25.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
ASP A 145
 None
 0.69A 5l2iA-2jgzA:
18.9		 5l2iA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
 None
 0.66A 5l2iA-2jgzA:
18.9		 5l2iA-2jgzA:
48.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
VAL A 436
ALA A 452
VAL A 484
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.2A)
 0.73A 5l2iA-2jkmA:
10.3		 5l2iA-2jkmA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 589
VAL A 596
ALA A 614
VAL A 647
ASP A 670
LEU A 785
 None
 0.56A 5l2iA-2ogvA:
8.1		 5l2iA-2ogvA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
ALA A 215
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.65A 5l2iA-2v55A:
7.5		 5l2iA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 ILE A 490
GLY A 491
VAL A 498
ALA A 509
PHE A 605
ASP A 611
LEU A 656
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-4.1A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
 0.85A 5l2iA-2vuwA:
15.5		 5l2iA-2vuwA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  53
VAL A  60
ALA A  73
LEU A 171
ALA A 184
ASP A 185
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.1A)
DKI  A1338 (-3.8A)
 0.68A 5l2iA-2w4oA:
7.2		 5l2iA-2w4oA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
ASP B  99
THR B 102
LEU B 147
ALA B 157
 None
 0.63A 5l2iA-2w9fB:
12.1		 5l2iA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE B  12
GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
THR B 102
LEU B 147
ALA B 157
 None
 0.77A 5l2iA-2w9fB:
12.1		 5l2iA-2w9fB:
69.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
 0.63A 5l2iA-2z7rA:
8.7		 5l2iA-2z7rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.74A 5l2iA-2z7rA:
8.7		 5l2iA-2z7rA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.63A 5l2iA-3bhhA:
7.6		 5l2iA-3bhhA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
 3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
 0.68A 5l2iA-3c0iA:
7.7		 5l2iA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
GLY A 202
VAL A 209
ALA A 220
VAL A 249
LEU A 321
 None
 0.72A 5l2iA-3d7uA:
7.2		 5l2iA-3d7uA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  23
GLY A  24
VAL A  31
ALA A  44
VAL A  76
LEU A 153
ALA A 163
 ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
 0.73A 5l2iA-3dakA:
5.5		 5l2iA-3dakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.66A 5l2iA-3f2aA:
22.9		 5l2iA-3f2aA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  60
VAL A  67
ALA A  80
VAL A 113
LEU A 182
ALA A 192
 None
 0.70A 5l2iA-3iecA:
7.6		 5l2iA-3iecA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 GLY A 211
VAL A 218
ALA A 229
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.70A 5l2iA-3mdyA:
6.3		 5l2iA-3mdyA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  46
VAL A  79
PHE A 103
ASP A 109
LEU A 156
ALA A 166
ASP A 167
 None
 0.82A 5l2iA-3mi9A:
12.6		 5l2iA-3mi9A:
36.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  25
VAL A  33
ALA A  46
VAL A  79
PHE A 103
ASP A 109
LEU A 156
ALA A 166
 None
 0.78A 5l2iA-3mi9A:
12.6		 5l2iA-3mi9A:
36.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 172
VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
ALA A 303
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.56A 5l2iA-3mtlA:
18.0		 5l2iA-3mtlA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 GLY A  30
VAL A  37
ALA A  49
VAL A  82
ASP A 104
LEU A 151
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.1A)
ADP  A 314 (-4.6A)
None
 0.81A 5l2iA-3nizA:
13.6		 5l2iA-3nizA:
45.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
VAL A 247
ASP A 270
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.58A 5l2iA-3nyoA:
7.8		 5l2iA-3nyoA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  38
VAL A  72
PHE A  90
ASP A  96
LEU A 141
ALA A 151
 None
 0.73A 5l2iA-3oz6A:
13.9		 5l2iA-3oz6A:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ILE A 557
GLY A 558
VAL A 565
ALA A 576
VAL A 609
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
 0.68A 5l2iA-3ppzA:
6.5		 5l2iA-3ppzA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  83
VAL A  90
ALA A 103
ASP A 160
THR A 163
LEU A 207
ALA A 217
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.66A 5l2iA-3qfvA:
6.5		 5l2iA-3qfvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 362
VAL A 369
ALA A 382
ASP A 440
LEU A 486
ALA A 496
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.46A 5l2iA-3txoA:
20.1		 5l2iA-3txoA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
TYR A  15
VAL A  18
ALA A  31
VAL A  63
PHE A  79
LEU A 132
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.3A)
 0.79A 5l2iA-3zduA:
12.4		 5l2iA-3zduA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 ( 4.3A)
D15  A 500 (-4.5A)
 0.64A 5l2iA-4aguA:
16.4		 5l2iA-4aguA:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 561
VAL A 568
ALA A 586
VAL A 617
PHE A 633
ASP A 640
LEU A 699
 LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
 1.20A 5l2iA-4at3A:
6.7		 5l2iA-4at3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A  84
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
None
 0.74A 5l2iA-4aw2A:
7.1		 5l2iA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A  83
GLY A  84
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
 0.90A 5l2iA-4aw2A:
7.1		 5l2iA-4aw2A:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.58A 5l2iA-4bbmA:
13.2		 5l2iA-4bbmA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
TYR A  24
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 (-3.6A)
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.85A 5l2iA-4bgqA:
16.7		 5l2iA-4bgqA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
VAL A 721
ASP A 744
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.45A 5l2iA-4crsA:
8.0		 5l2iA-4crsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.65A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.03A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  16
VAL A  23
ALA A  36
VAL A  68
THR A  96
ASP A 157
 BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.7A)
BX7  A 401 ( 3.7A)
 0.74A 5l2iA-4eutA:
20.4		 5l2iA-4eutA:
26.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  20
VAL A  27
VAL A  77
PHE A  98
ASP A 104
THR A 106
LEU A 152
ALA A 162
ASP A 163
 None
None
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 1.32A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		11 ILE A  19
GLY A  20
VAL A  27
ALA A  41
VAL A  77
PHE A  98
ASP A 104
THR A 107
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.55A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 516
VAL A 523
ALA A 541
VAL A 572
PHE A 588
ASP A 595
LEU A 656
 None
 0.83A 5l2iA-4f0iA:
6.5		 5l2iA-4f0iA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  29
GLY A  30
VAL A  37
ALA A  50
VAL A  84
ASP A 107
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
 0.74A 5l2iA-4fr4A:
6.9		 5l2iA-4fr4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
VAL A 836
ALA A 853
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.56A 5l2iA-4hviA:
22.9		 5l2iA-4hviA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 628
VAL A 635
ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
 None
 0.64A 5l2iA-4otdA:
7.3		 5l2iA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 635
ALA A 648
VAL A 685
ASP A 708
LEU A 753
ALA A 763
ASP A 764
 None
 0.89A 5l2iA-4otdA:
7.3		 5l2iA-4otdA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 387
VAL A 394
ALA A 407
ASP A 465
LEU A 511
ALA A 521
 PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.72A 5l2iA-4q9zA:
7.4		 5l2iA-4q9zA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  48
GLY A  49
TYR A  53
VAL A  56
ALA A  69
ASP A 128
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.5A)
None
38Z  A 418 (-3.4A)
EDO  A 413 (-2.9A)
38Z  A 418 (-4.4A)
 0.75A 5l2iA-4qtbA:
14.0		 5l2iA-4qtbA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  32
ALA A  45
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.72A 5l2iA-4rewA:
8.0		 5l2iA-4rewA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
P30  A1001 (-4.6A)
 0.51A 5l2iA-4rt7A:
6.7		 5l2iA-4rt7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 194
VAL A 201
ALA A 214
VAL A 248
ASP A 271
LEU A 321
 None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.67A 5l2iA-4wboA:
22.2		 5l2iA-4wboA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.3A)
 0.54A 5l2iA-4xufA:
6.9		 5l2iA-4xufA:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  13
ALA A  31
VAL A  64
ASP A  86
LEU A 135
ALA A 145
ASP A 146
 None
 1.34A 5l2iA-4yc6A:
14.6		 5l2iA-4yc6A:
45.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 135
ALA A 145
 None
 0.68A 5l2iA-4yc6A:
14.6		 5l2iA-4yc6A:
45.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 470
VAL A 477
ALA A 488
LEU A 595
ALA A 605
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
 0.51A 5l2iA-4yffA:
21.4		 5l2iA-4yffA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
GLY A 470
VAL A 477
ALA A 488
LEU A 595
ALA A 605
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.69A 5l2iA-4yffA:
21.4		 5l2iA-4yffA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 194
VAL A 201
ALA A 214
VAL A 248
ASP A 271
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
None
 0.71A 5l2iA-4yhjA:
9.2		 5l2iA-4yhjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 165
GLY A 166
VAL A 173
ALA A 186
VAL A 222
PHE A 238
LEU A 294
 4E1  A 505 ( 4.6A)
4E1  A 505 (-3.5A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
4E1  A 505 (-4.2A)
None
 0.74A 5l2iA-4yljA:
12.8		 5l2iA-4yljA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
VAL A  76
ASP A  99
ALA A 164
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
None
GOL  A 404 (-3.2A)
 0.82A 5l2iA-5ci7A:
8.1		 5l2iA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
VAL A  76
ASP A  99
LEU A 145
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
None
 0.61A 5l2iA-5ci7A:
8.1		 5l2iA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A  81
GLY A  82
VAL A  89
ALA A 102
VAL A 134
LEU A 211
 ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
 0.67A 5l2iA-5dbxA:
5.2		 5l2iA-5dbxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
ALA A  83
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 ( 3.9A)
 0.65A 5l2iA-5es1A:
8.0		 5l2iA-5es1A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASP A 681
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.55A 5l2iA-5grnA:
22.4		 5l2iA-5grnA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 GLY A  86
VAL A  93
ALA A 104
VAL A 133
THR A 157
LEU A 214
 ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
None
ADP  A 401 (-4.4A)
 0.52A 5l2iA-5gzaA:
15.7		 5l2iA-5gzaA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 GLY A  21
VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
 ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.69A 5l2iA-5hu3A:
7.9		 5l2iA-5hu3A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  50
ASP A 103
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.63A 5l2iA-5idnA:
14.3		 5l2iA-5idnA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  50
PHE A  97
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.68A 5l2iA-5idnA:
14.3		 5l2iA-5idnA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		7 ILE A  24
GLY A  25
VAL A  32
ALA A  45
VAL A  78
PHE A  94
LEU A 147
 None
 0.84A 5l2iA-5ig1A:
7.8		 5l2iA-5ig1A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
VAL A  30
ALA A  43
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.60A 5l2iA-5isoA:
7.8		 5l2iA-5isoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.64A 5l2iA-5j5tA:
20.9		 5l2iA-5j5tA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 0.63A 5l2iA-5jznA:
7.9		 5l2iA-5jznA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  41
VAL A  49
ALA A  60
VAL A  94
ASP A 117
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
 0.59A 5l2iA-5lohA:
8.3		 5l2iA-5lohA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
GLY A 156
VAL A 163
ALA A 176
PHE A 228
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.9A)
 0.48A 5l2iA-5lxdA:
16.1		 5l2iA-5lxdA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  99
VAL A 106
ALA A 119
VAL A 157
PHE A 177
LEU A 232
 W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
DMS  A 717 ( 3.9A)
None
 0.74A 5l2iA-5myvA:
14.6		 5l2iA-5myvA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 8 ILE A 358
GLY A 359
VAL A 366
ALA A 379
VAL A 413
ASP A 436
THR A 439
LEU A 482
 ANP  A 801 (-4.2A)
ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-3.4A)
None
ANP  A 801 (-4.8A)
 0.79A 5l2iA-5nclA:
21.3		 5l2iA-5nclA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  99
VAL A 106
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 0.55A 5l2iA-5u7qA:
7.6		 5l2iA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 GLY A  87
VAL A  94
ALA A 107
VAL A 145
PHE A 165
LEU A 220
ALA A 496
 EMH  A 705 ( 3.9A)
EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.9A)
EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.0A)
 0.89A 5l2iA-5xv7A:
10.9		 5l2iA-5xv7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 GLY A 216
VAL A 223
ALA A 236
PHE A 288
ASP A 294
LEU A 342
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 (-3.6A)
None
None
 0.66A 5l2iA-5y86A:
13.1		 5l2iA-5y86A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 9 GLY A 734
VAL A 741
ALA A 754
VAL A 787
PHE A 813
ASP A 819
LEU A 866
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 0.89A 5l2iA-6b3eA:
13.1		 5l2iA-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ILE A 733
GLY A 734
VAL A 741
ALA A 754
PHE A 813
ASP A 819
LEU A 866
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
 0.74A 5l2iA-6b3eA:
13.1		 5l2iA-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 GLY A 172
VAL A 179
ALA A 192
VAL A 249
PHE A 267
LEU A 319
ALA A 329
 BI9  A 501 (-3.6A)
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
None
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.84A 5l2iA-6bqlA:
8.0		 5l2iA-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 ILE A  66
GLY A  67
VAL A  74
ALA A  87
VAL A 120
LEU A 189
ALA A 199
 None
 0.91A 5l2iA-6c9dA:
7.8		 5l2iA-6c9dA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 GLY A 135
TYR A 139
VAL A 142
ALA A 155
VAL A 212
LEU A 282
ALA A 292
 H1N  A 501 ( 3.8A)
None
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.70A 5l2iA-6ccfA:
8.3		 5l2iA-6ccfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 7 GLY A 135
VAL A 142
ALA A 155
VAL A 212
PHE A 230
LEU A 282
ALA A 292
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.63A 5l2iA-6ccfA:
8.3		 5l2iA-6ccfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 GLY A 172
VAL A 179
ALA A 192
VAL A 249
PHE A 267
LEU A 319
ALA A 329
ASP A 330
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
None
F6J  A 501 (-3.7A)
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
F6J  A 501 (-3.8A)
 0.81A 5l2iA-6cmjA:
22.4		 5l2iA-6cmjA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 GLY A 168
VAL A 175
ALA A 189
VAL A 225
PHE A 241
LEU A 295
 None
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.9A)
 0.64A 5l2iA-6fyoA:
9.9		 5l2iA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		4 LYS 1 407
HIS 1 270
VAL 1 272
ASN 1 411
 None
 1.48A 5l2iA-1gff1:
0.0		 5l2iA-1gff1:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		4 LYS A  50
HIS A 123
VAL A 122
ASN A  31
 None
 1.48A 5l2iA-3f81A:
0.0		 5l2iA-3f81A:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  43
HIS A 100
VAL A 101
ASN A 150
 0RS  A 900 (-3.3A)
0RS  A 900 (-4.1A)
0RS  A 900 (-4.5A)
None
 0.79A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		4 LYS A 194
HIS A 175
VAL A 171
ASN A 240
 None
 1.06A 5l2iA-4f78A:
undetectable		 5l2iA-4f78A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 LYS A 381
HIS A 190
VAL A 189
ASN A 389
 None
 1.11A 5l2iA-4jjaA:
0.0		 5l2iA-4jjaA:
21.16