SIMILAR PATTERNS OF AMINO ACIDS FOR 5L1F_D_6ZPD902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.48A 5l1fD-1cu1A:
3.7		 5l1fD-1cu1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 SER A  90
ASP A  92
PRO A  38
LEU A  94
SER A 156
 None
 1.45A 5l1fD-1qonA:
2.4		 5l1fD-1qonA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 PRO A  45
TYR A 134
ASN A 267
LEU A 266
ASN A  35
 None
 1.03A 5l1fD-2gfiA:
2.1		 5l1fD-2gfiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 SER A  81
ASP A  83
PRO A  33
LEU A  85
SER A 114
 SER  A  81 ( 0.0A)
ASP  A  83 ( 0.6A)
PRO  A  33 ( 1.1A)
LEU  A  85 ( 0.6A)
SER  A 114 ( 0.0A)
 1.49A 5l1fD-2ogsA:
2.7		 5l1fD-2ogsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr1 UNCHARACTERIZED
N-ACETYLTRANSFERASE
YLBP

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 SER A 119
PHE A 122
PRO A 115
ASN A 114
LEU A 144
 COA  A 206 (-4.0A)
COA  A 206 (-3.9A)
None
None
None
 1.46A 5l1fD-2pr1A:
undetectable		 5l1fD-2pr1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		5 SER A 145
PHE A 142
ASN A 108
LEU A 107
SER A 101
 None
 1.41A 5l1fD-2xt4A:
undetectable		 5l1fD-2xt4A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		5 PRO A 162
TYR A  23
ASN A 161
PHE A 167
ASN A  97
 None
 1.18A 5l1fD-3i9fA:
2.5		 5l1fD-3i9fA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		5 PHE A 379
ASP A 362
LEU A 360
SER A 138
ASN A 140
 None
 1.33A 5l1fD-4fo0A:
2.5		 5l1fD-4fo0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		5 SER A 181
PRO A  68
TYR A  66
ASN A  67
ASN A  71
 None
 1.49A 5l1fD-4hk9A:
undetectable		 5l1fD-4hk9A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo sapiens;
Mus musculus) 		PF00027
(cNMP_binding)
PF00071
(Ras)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 PRO E 884
TYR R  71
ASN R  74
LEU R  56
ASN E 887
 None
 1.42A 5l1fD-4mh0E:
2.6		 5l1fD-4mh0E:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		5 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.47A 5l1fD-4wxpA:
2.9		 5l1fD-4wxpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 5 PHE A  81
TYR A  53
LEU A  56
PHE A  94
ASN A  86
 None
None
None
SO4  A 301 ( 4.9A)
None
 1.42A 5l1fD-5bmtA:
undetectable		 5l1fD-5bmtA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 SER A 244
PHE A 246
PRO A 335
ASN A  11
LEU A  13
 None
 1.45A 5l1fD-5h05A:
undetectable		 5l1fD-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxf 3C PROTEASE

(Enterovirus A) 		PF00548
(Peptidase_C3) 		5 PHE A  84
ASP A  86
PHE A  90
SER A  10
ASN A  15
 None
 1.48A 5l1fD-5hxfA:
undetectable		 5l1fD-5hxfA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.47A 5l1fD-5wdxA:
3.9		 5l1fD-5wdxA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 PHE A 517
ASP A 519
PRO A 520
TYR A 616
LEU A 620
SER A 788
 None
 1.35A 5l1fD-5welA:
55.6		 5l1fD-5welA:
78.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A 517
PRO A 520
TYR A 616
ASN A 619
LEU A 620
 None
 1.04A 5l1fD-5weoA:
51.5		 5l1fD-5weoA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 516
ASP A 519
PRO A 520
TYR A 616
LEU A 620
 None
 1.18A 5l1fD-5weoA:
51.5		 5l1fD-5weoA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 516
PHE A 517
PRO A 520
TYR A 616
LEU A 620
 None
 1.29A 5l1fD-5weoA:
51.5		 5l1fD-5weoA:
77.54