SIMILAR PATTERNS OF AMINO ACIDS FOR 5L1F_B_6ZPB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 SER A 444
SER A 216
ASP A 219
PRO A 320
SER A 369
 None
 1.45A 5l1fB-1b0kA:
1.2		 5l1fB-1b0kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 SER A  70
PRO A  81
TYR A 123
LEU A 107
SER A  26
 None
 1.43A 5l1fB-2i7tA:
0.0		 5l1fB-2i7tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		5 SER A 628
PRO A 626
PHE A 547
SER A 657
ASN A 656
 None
 1.46A 5l1fB-3fw0A:
undetectable		 5l1fB-3fw0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 SER A  46
ASP A  41
TYR A 327
LEU A 323
PHE A  42
 None
 1.31A 5l1fB-3tc8A:
1.2		 5l1fB-3tc8A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		5 ASP A 281
PRO A 299
TYR A 323
LEU A 295
SER A 251
 1PE  A 403 ( 2.6A)
None
None
None
None
 1.48A 5l1fB-5cdhA:
2.6		 5l1fB-5cdhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		5 SER A  38
ASP A  57
TYR A 417
LEU A 411
SER A  86
 None
 1.48A 5l1fB-5gnxA:
0.0		 5l1fB-5gnxA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 523
PRO A 527
TYR A 620
LEU A 624
PHE A 627
 None
 1.06A 5l1fB-5kufA:
39.2		 5l1fB-5kufA:
39.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 SER A 828
PRO A 830
TYR A 923
LEU A 833
SER A 758
 None
 1.34A 5l1fB-5txkA:
0.7		 5l1fB-5txkA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 ASP A 519
PRO A 520
TYR A 616
LEU A 620
SER A 788
ASN A 791
 None
 1.11A 5l1fB-5welA:
55.3		 5l1fB-5welA:
78.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 ASP A 519
PRO A 520
TYR A 616
LEU A 620
SER A 790
ASN A 791
 None
 1.28A 5l1fB-5welA:
55.3		 5l1fB-5welA:
78.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 516
ASP A 519
PRO A 520
LEU A 620
SER A 788
 None
 1.48A 5l1fB-5weoA:
52.0		 5l1fB-5weoA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 SER A 516
ASP A 519
PRO A 520
TYR A 616
LEU A 620
 None
 1.11A 5l1fB-5weoA:
52.0		 5l1fB-5weoA:
77.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 ASP A 441
LEU B  22
PHE A 468
SER B 114
ASN B 115
 None
 1.38A 5l1fB-6c9mA:
0.1		 5l1fB-6c9mA:
7.42