SIMILAR PATTERNS OF AMINO ACIDS FOR 5L1F_A_6ZPA902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 PRO A 188
TYR A 121
SER A  89
SER A 193
 None
None
GLC  A 550 ( 4.2A)
None
 1.01A 5l1fA-1b1yA:
undetectable
5l1fB-1b1yA:
undetectable		 5l1fA-1b1yA:
20.10
5l1fB-1b1yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 ASP B 293
TYR B 339
SER B 386
ASN B 478
 None
 0.91A 5l1fA-1cp9B:
undetectable
5l1fB-1cp9B:
undetectable		 5l1fA-1cp9B:
21.11
5l1fB-1cp9B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		4 PRO A  56
TYR A  93
SER A  83
ASN A  46
 None
 1.13A 5l1fA-1d2kA:
1.3
5l1fB-1d2kA:
undetectable		 5l1fA-1d2kA:
19.63
5l1fB-1d2kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddh MHC CLASS I H-2DD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 SER A  73
ASP A  77
PHE A 116
ASN A  70
 None
 1.12A 5l1fA-1ddhA:
undetectable
5l1fB-1ddhA:
undetectable		 5l1fA-1ddhA:
14.95
5l1fB-1ddhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PRO A 283
TYR A 303
SER A 455
SER A 287
 None
 1.13A 5l1fA-1fprA:
undetectable
5l1fB-1fprA:
undetectable		 5l1fA-1fprA:
17.66
5l1fB-1fprA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwd ERVATAMIN B

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		4 PRO A 128
SER A  47
ASN A  14
SER A 130
 None
 1.14A 5l1fA-1iwdA:
undetectable
5l1fB-1iwdA:
undetectable		 5l1fA-1iwdA:
14.56
5l1fB-1iwdA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 ASP A  22
TYR A 164
PHE A 152
SER A  29
 None
None
GKR  A 499 (-4.7A)
None
 1.12A 5l1fA-1jctA:
undetectable
5l1fB-1jctA:
undetectable		 5l1fA-1jctA:
20.20
5l1fB-1jctA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 312
PRO A 101
TYR A 209
ASN A 314
 ZN  A 700 ( 2.4A)
None
None
None
 1.08A 5l1fA-1kfiA:
undetectable
5l1fB-1kfiA:
2.1		 5l1fA-1kfiA:
21.24
5l1fB-1kfiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 376
ASP A 470
PRO A 446
SER A 476
 None
 1.13A 5l1fA-1kyaA:
undetectable
5l1fB-1kyaA:
undetectable		 5l1fA-1kyaA:
21.15
5l1fB-1kyaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 291
PRO A  96
TYR A 194
ASN A 293
 CD  A 562 (-3.3A)
None
None
None
 1.05A 5l1fA-1lxtA:
undetectable
5l1fB-1lxtA:
undetectable		 5l1fA-1lxtA:
22.85
5l1fB-1lxtA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 PRO A 131
TYR A 218
SER A  98
ASN A  43
 None
 1.13A 5l1fA-1nbqA:
undetectable
5l1fB-1nbqA:
undetectable		 5l1fA-1nbqA:
15.03
5l1fB-1nbqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 SER A 127
PRO A 129
SER A 122
SER A 134
 None
 1.04A 5l1fA-1op2A:
undetectable
5l1fB-1op2A:
undetectable		 5l1fA-1op2A:
15.37
5l1fB-1op2A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 PRO A 405
PHE A 118
SER A  78
ASN A 400
 None
None
ALS  A  75 ( 4.7A)
None
 0.72A 5l1fA-1p49A:
3.5
5l1fB-1p49A:
3.9		 5l1fA-1p49A:
20.42
5l1fB-1p49A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 TYR A 286
PHE A 299
ASN A  54
SER A 296
 None
 1.13A 5l1fA-1p49A:
3.5
5l1fB-1p49A:
3.9		 5l1fA-1p49A:
20.42
5l1fB-1p49A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 TYR A 224
PHE A 229
ASN A 206
SER A 228
 None
 1.11A 5l1fA-1pc3A:
2.0
5l1fB-1pc3A:
3.9		 5l1fA-1pc3A:
19.17
5l1fB-1pc3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		4 SER A  96
ASP A  99
PHE A   6
SER A   3
 None
None
None
PCA  A   1 ( 4.3A)
 1.10A 5l1fA-1schA:
undetectable
5l1fB-1schA:
undetectable		 5l1fA-1schA:
16.14
5l1fB-1schA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 ASP A 132
PRO A 133
SER A 155
SER A 147
 MN  A1238 ( 2.9A)
None
None
MN  A1238 (-3.6A)
 0.94A 5l1fA-1v6mA:
undetectable
5l1fB-1v6mA:
undetectable		 5l1fA-1v6mA:
15.46
5l1fB-1v6mA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 SER A 207
ASP A 179
SER A  77
SER A  92
 None
PLP  A 513 (-2.8A)
None
None
 1.00A 5l1fA-1v72A:
2.1
5l1fB-1v72A:
1.9		 5l1fA-1v72A:
17.49
5l1fB-1v72A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 219
SER A 261
ASN A 215
SER A 454
 None
 1.10A 5l1fA-1xkhA:
undetectable
5l1fB-1xkhA:
undetectable		 5l1fA-1xkhA:
22.64
5l1fB-1xkhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		4 SER A  81
ASP A  83
SER A  10
ASN A  78
 None
 1.06A 5l1fA-1yzfA:
3.3
5l1fB-1yzfA:
4.6		 5l1fA-1yzfA:
14.41
5l1fB-1yzfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 SER A 398
ASP A 399
PHE A 450
SER A 425
 None
K  A 453 (-3.7A)
None
None
 1.09A 5l1fA-1zczA:
undetectable
5l1fB-1zczA:
undetectable		 5l1fA-1zczA:
21.81
5l1fB-1zczA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ASP A 521
PRO A 522
TYR A 411
PHE A 357
 None
 1.13A 5l1fA-2fknA:
undetectable
5l1fB-2fknA:
undetectable		 5l1fA-2fknA:
21.77
5l1fB-2fknA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz4 DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII) 		4 TYR A  29
PHE A 193
SER A 181
ASN A 185
 None
 1.11A 5l1fA-2fz4A:
2.8
5l1fB-2fz4A:
undetectable		 5l1fA-2fz4A:
14.46
5l1fB-2fz4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 613
PRO A 616
TYR A 563
SER A  87
 None
 1.09A 5l1fA-2h88A:
undetectable
5l1fB-2h88A:
undetectable		 5l1fA-2h88A:
20.51
5l1fB-2h88A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 PRO A 383
TYR A 495
PHE A 381
SER A 379
 None
None
HEM  A 900 (-4.5A)
None
 0.98A 5l1fA-2hi4A:
undetectable
5l1fB-2hi4A:
undetectable		 5l1fA-2hi4A:
21.21
5l1fB-2hi4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huo INOSITOL OXYGENASE

(Mus musculus) 		PF05153
(MIOX) 		4 ASP A 142
PRO A 224
TYR A 231
SER A 159
 INS  A 303 (-3.5A)
None
None
None
 1.09A 5l1fA-2huoA:
undetectable
5l1fB-2huoA:
undetectable		 5l1fA-2huoA:
16.53
5l1fB-2huoA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 376
ASP A 470
PRO A 446
SER A 476
 None
 1.11A 5l1fA-2hzhA:
undetectable
5l1fB-2hzhA:
undetectable		 5l1fA-2hzhA:
20.76
5l1fB-2hzhA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOUB PROTEIN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF06234
(TmoB) 		4 TYR A 337
PHE C  10
ASN C  40
SER C   8
 None
 0.92A 5l1fA-2incA:
1.0
5l1fB-2incA:
undetectable		 5l1fA-2incA:
22.35
5l1fB-2incA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 SER A 238
ASP A 250
PRO A 251
PHE A 253
 None
MG  A 401 ( 2.8A)
None
SR1  A 998 (-4.3A)
 1.11A 5l1fA-2punA:
undetectable
5l1fB-2punA:
undetectable		 5l1fA-2punA:
19.53
5l1fB-2punA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		4 SER A 243
ASP A 255
PRO A 256
PHE A 258
 MG  A 501 ( 4.5A)
MG  A 500 (-1.8A)
None
SR1  A 998 (-4.2A)
 1.10A 5l1fA-2pywA:
1.6
5l1fB-2pywA:
1.8		 5l1fA-2pywA:
19.95
5l1fB-2pywA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 PRO A 247
TYR A 280
SER A 290
SER A 211
 None
 1.11A 5l1fA-2qe8A:
undetectable
5l1fB-2qe8A:
undetectable		 5l1fA-2qe8A:
20.18
5l1fB-2qe8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 ASP A 126
TYR A  25
SER A 243
ASN A 244
 None
 1.14A 5l1fA-2qi2A:
undetectable
5l1fB-2qi2A:
undetectable		 5l1fA-2qi2A:
17.52
5l1fB-2qi2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		4 SER A 151
TYR A 100
PHE A 271
SER A 209
 PEG  A 360 (-3.2A)
None
UNL  A 359 (-4.8A)
None
 1.10A 5l1fA-2rauA:
2.7
5l1fB-2rauA:
undetectable		 5l1fA-2rauA:
19.05
5l1fB-2rauA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs2 RNA-BINDING PROTEIN
MUSASHI HOMOLOG 1

(Mus musculus) 		PF00076
(RRM_1) 		4 ASP A  91
PRO A  92
PHE A  23
SER A  60
 U  B 105 ( 2.8A)
None
A  B 106 ( 3.7A)
G  B 104 ( 4.7A)
 1.03A 5l1fA-2rs2A:
undetectable
5l1fB-2rs2A:
undetectable		 5l1fA-2rs2A:
8.68
5l1fB-2rs2A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 SER A 146
ASP A 148
TYR A 155
ASN A 141
 None
 1.13A 5l1fA-2w61A:
undetectable
5l1fB-2w61A:
undetectable		 5l1fA-2w61A:
22.01
5l1fB-2w61A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		4 PRO A 504
PHE A 258
SER A 440
ASN A 411
 None
 1.00A 5l1fA-2w8dA:
undetectable
5l1fB-2w8dA:
undetectable		 5l1fA-2w8dA:
19.57
5l1fB-2w8dA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 168
ASP A  18
PRO A  17
SER A 204
 None
 1.13A 5l1fA-2xybA:
undetectable
5l1fB-2xybA:
undetectable		 5l1fA-2xybA:
20.48
5l1fB-2xybA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 SER A 600
ASP A 995
TYR A 656
SER A 661
 None
 1.13A 5l1fA-2ya1A:
undetectable
5l1fB-2ya1A:
undetectable		 5l1fA-2ya1A:
22.94
5l1fB-2ya1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 PRO A 111
TYR A 152
ASN A 172
SER A 109
 None
None
None
ZN  A1292 ( 4.7A)
 1.11A 5l1fA-2ygtA:
undetectable
5l1fB-2ygtA:
undetectable		 5l1fA-2ygtA:
16.25
5l1fB-2ygtA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 SER B 140
SER A  55
ASN B  36
SER B 144
 None
 1.14A 5l1fA-2z5cB:
undetectable
5l1fB-2z5cB:
undetectable		 5l1fA-2z5cB:
11.57
5l1fB-2z5cB:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdi UNCHARACTERIZED
PROTEIN TA0194

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1)
PF12146
(Hydrolase_4) 		4 SER A  39
ASP A  62
TYR A  92
PHE A   7
 None
 0.99A 5l1fA-3bdiA:
3.1
5l1fB-3bdiA:
3.0		 5l1fA-3bdiA:
14.97
5l1fB-3bdiA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		4 SER A  75
PRO A 124
SER A  45
SER A 140
 None
 1.12A 5l1fA-3fgbA:
undetectable
5l1fB-3fgbA:
undetectable		 5l1fA-3fgbA:
19.58
5l1fB-3fgbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		4 SER A 301
ASP A 307
PRO A 308
TYR A  59
 None
 1.13A 5l1fA-3fj1A:
undetectable
5l1fB-3fj1A:
2.3		 5l1fA-3fj1A:
18.09
5l1fB-3fj1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 PRO A  15
TYR A  20
SER A 209
ASN A 131
 None
 1.10A 5l1fA-3k94A:
2.3
5l1fB-3k94A:
2.4		 5l1fA-3k94A:
13.03
5l1fB-3k94A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 168
ASP A  18
PRO A  17
SER A 204
 None
 1.13A 5l1fA-3kw7A:
undetectable
5l1fB-3kw7A:
undetectable		 5l1fA-3kw7A:
21.28
5l1fB-3kw7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		4 ASP A   9
SER A  17
ASN A 253
SER A  45
 MG  A 271 (-2.9A)
None
None
None
 0.88A 5l1fA-3l7yA:
undetectable
5l1fB-3l7yA:
undetectable		 5l1fA-3l7yA:
17.12
5l1fB-3l7yA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv9 ALPHA CHAIN OF THE
TK3 TCR

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 SER D 158
ASP D 157
PRO D 133
ASN D 129
 None
 1.12A 5l1fA-3mv9D:
undetectable
5l1fB-3mv9D:
undetectable		 5l1fA-3mv9D:
13.36
5l1fB-3mv9D:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 PRO A 404
PHE A 442
ASN A 475
SER A 401
 None
 0.95A 5l1fA-3ohnA:
undetectable
5l1fB-3ohnA:
undetectable		 5l1fA-3ohnA:
21.50
5l1fB-3ohnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 SER A 872
ASP A 875
SER A 749
ASN A 746
SER A 738
 None
 1.16A 5l1fA-3opyA:
4.5
5l1fB-3opyA:
2.2		 5l1fA-3opyA:
21.83
5l1fB-3opyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pct CLASS C ACID
PHOSPHATASE

(Pasteurella
multocida) 		PF03767
(Acid_phosphat_B) 		4 ASP A 180
TYR A  32
SER A  99
ASN A  71
 None
 1.14A 5l1fA-3pctA:
undetectable
5l1fB-3pctA:
undetectable		 5l1fA-3pctA:
16.56
5l1fB-3pctA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		4 SER A  47
TYR A 126
SER A 101
ASN A  49
 None
 1.05A 5l1fA-3simA:
undetectable
5l1fB-3simA:
1.7		 5l1fA-3simA:
17.31
5l1fB-3simA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		4 PRO A  67
TYR A 117
SER A 180
SER A  64
 None
 1.11A 5l1fA-3tbjA:
undetectable
5l1fB-3tbjA:
undetectable		 5l1fA-3tbjA:
16.32
5l1fB-3tbjA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 ASP A 361
TYR A 309
ASN A 406
SER A 475
 None
 1.07A 5l1fA-3tk3A:
undetectable
5l1fB-3tk3A:
undetectable		 5l1fA-3tk3A:
19.48
5l1fB-3tk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 SER A 379
TYR A  88
SER A  57
ASN A  60
 None
 1.07A 5l1fA-3vqrA:
undetectable
5l1fB-3vqrA:
undetectable		 5l1fA-3vqrA:
21.23
5l1fB-3vqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 ASP A 221
PHE A 201
SER A 197
SER A 205
 None
 1.13A 5l1fA-3wdyA:
undetectable
5l1fB-3wdyA:
undetectable		 5l1fA-3wdyA:
17.16
5l1fB-3wdyA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 ASP A 432
PRO A 431
SER A  46
ASN A  47
 None
 0.98A 5l1fA-3x0uA:
2.3
5l1fB-3x0uA:
undetectable		 5l1fA-3x0uA:
20.25
5l1fB-3x0uA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		4 SER A 147
ASP A 217
PHE A  86
SER A  84
 None
 1.04A 5l1fA-4ajtA:
undetectable
5l1fB-4ajtA:
undetectable		 5l1fA-4ajtA:
21.22
5l1fB-4ajtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 SER A 243
ASP A 245
ASN A 241
SER A 347
 None
 1.09A 5l1fA-4ayrA:
undetectable
5l1fB-4ayrA:
undetectable		 5l1fA-4ayrA:
19.45
5l1fB-4ayrA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 SER A  45
ASP A  47
PRO A  51
TYR A  72
 None
 0.92A 5l1fA-4b5mA:
undetectable
5l1fB-4b5mA:
undetectable		 5l1fA-4b5mA:
14.84
5l1fB-4b5mA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 ASP A  92
TYR A 108
ASN A 213
SER A 130
 None
None
None
VKC  A1294 ( 3.8A)
 0.82A 5l1fA-4ccwA:
undetectable
5l1fB-4ccwA:
undetectable		 5l1fA-4ccwA:
17.65
5l1fB-4ccwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ASP A  36
SER A 115
ASN A 116
SER A  86
 None
 1.12A 5l1fA-4czpA:
undetectable
5l1fB-4czpA:
undetectable		 5l1fA-4czpA:
19.70
5l1fB-4czpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 ASP A 604
TYR A 572
SER A 650
ASN A 651
 None
 1.01A 5l1fA-4dloA:
undetectable
5l1fB-4dloA:
undetectable		 5l1fA-4dloA:
20.45
5l1fB-4dloA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 277
PHE A 258
ASN A 242
SER A 291
 FAD  A 501 (-2.9A)
None
FAD  A 501 (-4.2A)
None
 1.04A 5l1fA-4emwA:
undetectable
5l1fB-4emwA:
undetectable		 5l1fA-4emwA:
20.90
5l1fB-4emwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		4 TYR A  28
PHE A  55
SER A 164
SER A  54
 GOL  A 302 ( 4.9A)
None
None
None
 1.06A 5l1fA-4fd4A:
undetectable
5l1fB-4fd4A:
undetectable		 5l1fA-4fd4A:
13.96
5l1fB-4fd4A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 SER A 378
PRO A 250
TYR A 420
ASN A 305
 None
 1.11A 5l1fA-4fnmA:
undetectable
5l1fB-4fnmA:
undetectable		 5l1fA-4fnmA:
22.24
5l1fB-4fnmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE

(Actinobacillus
succinogenes) 		PF13378
(MR_MLE_C) 		4 ASP A  18
TYR A 160
PHE A 148
SER A  25
 None
None
SO4  A 501 (-4.8A)
None
 1.13A 5l1fA-4g8tA:
undetectable
5l1fB-4g8tA:
undetectable		 5l1fA-4g8tA:
20.61
5l1fB-4g8tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 PRO A 383
TYR A 494
PHE A 381
SER A 379
 None
None
HEM  A 601 (-4.8A)
None
 1.02A 5l1fA-4i8vA:
undetectable
5l1fB-4i8vA:
undetectable		 5l1fA-4i8vA:
20.94
5l1fB-4i8vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 SER H  35
TYR L  36
PHE L  96
SER H  97
 1WE  L 300 (-3.6A)
None
1WE  L 300 ( 4.7A)
None
 1.05A 5l1fA-4larH:
undetectable
5l1fB-4larH:
undetectable		 5l1fA-4larH:
10.06
5l1fB-4larH:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll9 LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens) 		PF00047
(ig) 		4 SER A   3
PRO A   6
SER A  85
SER A  58
 None
 1.09A 5l1fA-4ll9A:
undetectable
5l1fB-4ll9A:
undetectable		 5l1fA-4ll9A:
14.29
5l1fB-4ll9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ASP D 121
PHE D 123
SER D 958
ASN D 128
 None
 1.13A 5l1fA-4ngeD:
undetectable
5l1fB-4ngeD:
undetectable		 5l1fA-4ngeD:
23.74
5l1fB-4ngeD:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 SER A 118
ASP A 144
PRO A 143
SER A 261
 None
 1.09A 5l1fA-4o8mA:
undetectable
5l1fB-4o8mA:
5.3		 5l1fA-4o8mA:
17.60
5l1fB-4o8mA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		4 ASP B 293
TYR B 339
SER B 386
ASN B 478
 None
 0.92A 5l1fA-4pelB:
undetectable
5l1fB-4pelB:
undetectable		 5l1fA-4pelB:
21.24
5l1fB-4pelB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Marinobacter
hydrocarbonoclasticus) 		PF03480
(DctP) 		4 SER A 252
TYR A 203
SER A 193
ASN A 124
 None
 1.10A 5l1fA-4pfiA:
2.5
5l1fB-4pfiA:
4.3		 5l1fA-4pfiA:
16.81
5l1fB-4pfiA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 SER A 247
PRO A 221
SER A 275
SER A 225
 None
 1.14A 5l1fA-4pxqA:
undetectable
5l1fB-4pxqA:
undetectable		 5l1fA-4pxqA:
21.53
5l1fB-4pxqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 SER A 605
ASP A 535
TYR A 686
SER A 539
 None
 1.13A 5l1fA-4qi4A:
undetectable
5l1fB-4qi4A:
undetectable		 5l1fA-4qi4A:
21.90
5l1fB-4qi4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 TYR A 182
PHE A 127
SER A 173
ASN A 320
 None
 0.95A 5l1fA-4u9cA:
undetectable
5l1fB-4u9cA:
undetectable		 5l1fA-4u9cA:
19.43
5l1fB-4u9cA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp8 MA1120

(Mycobacterium
avium) 		PF00211
(Guanylate_cyc) 		4 SER A  65
ASP A 105
ASN A  69
SER A 102
 ZDA  A 303 (-3.0A)
MN  A 301 ( 2.7A)
None
None
 1.13A 5l1fA-4wp8A:
undetectable
5l1fB-4wp8A:
undetectable		 5l1fA-4wp8A:
13.40
5l1fB-4wp8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 SER A 245
PHE A 358
ASN A 241
SER A 361
 None
 1.07A 5l1fA-4xeeA:
1.9
5l1fB-4xeeA:
undetectable		 5l1fA-4xeeA:
19.43
5l1fB-4xeeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 4 ASP A 236
SER A 354
ASN A 244
SER A 399
 MG  A 900 (-2.9A)
None
None
None
 1.12A 5l1fA-4xhpA:
2.3
5l1fB-4xhpA:
2.5		 5l1fA-4xhpA:
23.75
5l1fB-4xhpA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A 648
SER A 669
ASN A 666
SER A 604
 None
 1.10A 5l1fA-4yhcA:
undetectable
5l1fB-4yhcA:
undetectable		 5l1fA-4yhcA:
20.12
5l1fB-4yhcA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 PRO A 148
TYR A 150
PHE A 305
SER A 308
 None
 1.02A 5l1fA-4z81A:
undetectable
5l1fB-4z81A:
undetectable		 5l1fA-4z81A:
20.27
5l1fB-4z81A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		4 ASP A1381
TYR A1311
SER A1428
SER A1339
 None
 1.13A 5l1fA-4ziuA:
undetectable
5l1fB-4ziuA:
undetectable		 5l1fA-4ziuA:
21.35
5l1fB-4ziuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 TYR A 991
PHE A1002
SER A1202
ASN A1203
 None
 1.07A 5l1fA-5a22A:
undetectable
5l1fB-5a22A:
undetectable		 5l1fA-5a22A:
17.80
5l1fB-5a22A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 ASP A1381
TYR A1311
SER A1428
SER A1339
 None
 1.01A 5l1fA-5a42A:
undetectable
5l1fB-5a42A:
undetectable		 5l1fA-5a42A:
19.94
5l1fB-5a42A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		4 SER A 137
ASP A 140
PHE A  45
SER A  42
 None
 1.12A 5l1fA-5aogA:
undetectable
5l1fB-5aogA:
undetectable		 5l1fA-5aogA:
16.38
5l1fB-5aogA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		4 SER A 169
TYR A  88
ASN A 167
SER A 126
 None
 1.11A 5l1fA-5ej3A:
undetectable
5l1fB-5ej3A:
undetectable		 5l1fA-5ej3A:
15.35
5l1fB-5ej3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 PRO A 455
TYR A 437
SER A 400
ASN A 396
 None
 1.07A 5l1fA-5fkrA:
undetectable
5l1fB-5fkrA:
undetectable		 5l1fA-5fkrA:
22.75
5l1fB-5fkrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		4 ASP A 169
PRO A 168
TYR A 158
SER A 251
 None
 1.11A 5l1fA-5htpA:
undetectable
5l1fB-5htpA:
undetectable		 5l1fA-5htpA:
19.66
5l1fB-5htpA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 SER A 523
PRO A 527
TYR A 620
PHE A 627
 None
 1.12A 5l1fA-5kufA:
34.8
5l1fB-5kufA:
39.2		 5l1fA-5kufA:
39.87
5l1fB-5kufA:
39.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 ASP A 290
PRO A 289
PHE A  17
SER A  11
 None
 1.13A 5l1fA-5n2gA:
undetectable
5l1fB-5n2gA:
undetectable		 5l1fA-5n2gA:
6.63
5l1fB-5n2gA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 4 SER A  44
ASP A  76
PRO A 123
TYR A  92
 None
ZN  A 201 (-2.2A)
None
None
 0.94A 5l1fA-5opzA:
undetectable
5l1fB-5opzA:
undetectable		 5l1fA-5opzA:
7.64
5l1fB-5opzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 SER 5 174
ASP 5 252
PHE 3 298
SER 5 248
 None
 1.06A 5l1fA-5udb5:
undetectable
5l1fB-5udb5:
undetectable		 5l1fA-5udb5:
22.70
5l1fB-5udb5:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 SER A 258
PRO A  52
TYR A  54
SER A 318
 LLP  A 255 ( 4.3A)
None
None
BR  A 501 ( 4.9A)
 1.12A 5l1fA-5vehA:
undetectable
5l1fB-5vehA:
4.0		 5l1fA-5vehA:
19.16
5l1fB-5vehA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 ASP A 519
PRO A 520
TYR A 616
SER A 788
 None
 0.76A 5l1fA-5welA:
50.3
5l1fB-5welA:
55.3		 5l1fA-5welA:
78.61
5l1fB-5welA:
78.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
no annotation 		4 PHE A 480
SER B 298
ASN A 436
SER A 475
 None
 1.05A 5l1fA-5xjgA:
undetectable
5l1fB-5xjgA:
undetectable		 5l1fA-5xjgA:
21.80
5l1fB-5xjgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 SER A 600
ASP A  69
PRO A  70
SER A  67
 None
 1.12A 5l1fA-5z0uA:
undetectable
5l1fB-5z0uA:
undetectable		 5l1fA-5z0uA:
9.14
5l1fB-5z0uA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 SER A 423
PRO A 373
SER A 570
SER A 370
 None
 1.02A 5l1fA-6bdzA:
undetectable
5l1fB-6bdzA:
undetectable		 5l1fA-6bdzA:
7.02
5l1fB-6bdzA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Influenza A
virus;
Saccharomyces
cerevisiae) 		no annotation 4 TYR A 458
SER A 405
ASN A 409
SER A 526
 None
 1.04A 5l1fA-6cfpA:
undetectable
5l1fB-6cfpA:
undetectable		 5l1fA-6cfpA:
7.68
5l1fB-6cfpA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 4 ASP W 450
PRO W 449
PHE W 370
SER W 416
 None
 1.00A 5l1fA-6ftxW:
undetectable
5l1fB-6ftxW:
undetectable		 5l1fA-6ftxW:
undetectable
5l1fB-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 SER A 183
ASP A 186
SER A 408
SER A 203
 None
 0.90A 5l1fA-6gctA:
undetectable
5l1fB-6gctA:
undetectable		 5l1fA-6gctA:
8.71
5l1fB-6gctA:
8.71