SIMILAR PATTERNS OF AMINO ACIDS FOR 5L17_A_ZMRA512_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU N 134
ARG N 152
TRP N 178
ILE N 222
 None
 0.33A 5l17A-1nmbN:
72.9		 5l17A-1nmbN:
79.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 140
ARG A 158
TRP A 185
ILE A 229
 None
 0.24A 5l17A-1v0zA:
72.9		 5l17A-1v0zA:
68.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 132
ARG A 150
TRP A 177
ILE A 221
 None
IBA  A   1 (-3.9A)
None
IBA  A   1 ( 4.3A)
 0.49A 5l17A-1vcjA:
53.9		 5l17A-1vcjA:
31.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 135
ARG A 153
TRP A 180
ILE A 224
 None
ABW  A1000 (-4.1A)
None
ABW  A1000 ( 4.7A)
 0.14A 5l17A-1xogA:
74.8		 5l17A-1xogA:
93.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arc ARABINOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF02311
(AraC_binding) 		4 LEU A 161
ARG A 101
TRP A 104
ILE A 153
 None
 1.45A 5l17A-2arcA:
undetectable		 5l17A-2arcA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
 0.38A 5l17A-2htvA:
63.0		 5l17A-2htvA:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 200
ARG A  91
TRP A 199
ILE A 168
 None
 1.30A 5l17A-2y3sA:
undetectable		 5l17A-2y3sA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
None
None
 0.16A 5l17A-3ckzA:
64.6		 5l17A-3ckzA:
47.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		4 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.09A 5l17A-3e8sA:
undetectable		 5l17A-3e8sA:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
LNV  A 901 (-4.0A)
None
None
 0.18A 5l17A-3ti8A:
65.2		 5l17A-3ti8A:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
LNV  A 801 (-3.9A)
None
None
 0.13A 5l17A-3tiaA:
64.9		 5l17A-3tiaA:
44.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 LEU A 205
ARG A  51
TRP A  53
ILE A  22
 None
 1.34A 5l17A-3v7iA:
undetectable		 5l17A-3v7iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 131
ARG A 149
TRP A 176
ILE A 220
 None
ZMR  A 700 (-4.0A)
None
None
 0.17A 5l17A-4cpnA:
54.4		 5l17A-4cpnA:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
SLB  A 512 (-3.8A)
None
None
 0.15A 5l17A-4h53A:
64.9		 5l17A-4h53A:
48.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.15A 5l17A-4hzzA:
63.0		 5l17A-4hzzA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
27S  A 501 (-4.2A)
None
27S  A 501 ( 4.6A)
 0.30A 5l17A-4mjuA:
62.7		 5l17A-4mjuA:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A  52
ARG A  70
TRP A  97
ILE A 141
 None
 0.27A 5l17A-4qn3A:
71.3		 5l17A-4qn3A:
62.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
E3M  A 511 (-3.8A)
None
E3M  A 511 ( 4.3A)
 0.16A 5l17A-6br6A:
64.7		 5l17A-6br6A:
20.51