SIMILAR PATTERNS OF AMINO ACIDS FOR 5L0Z_B_SAMB304
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9h | PROTEIN(3-AMINO-5-HYDROXYBENZOIC ACID SYNTHASE) (Amycolatopsismediterranei) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 181GLY A 62GLY A 196ILE A 179ALA A 69 | NonePLP A 389 (-3.5A)NoneNoneNone | 0.94A | 5l0zB-1b9hA:undetectable | 5l0zB-1b9hA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cj0 | PROTEIN (SERINEHYDROXYMETHYLTRANSFERASE) (Oryctolaguscuniculus) |
PF00464(SHMT) | 5 | LEU A 402GLY A 389GLN A4061LEU A4111ALA A 408 | None | 1.03A | 5l0zB-1cj0A:undetectable | 5l0zB-1cj0A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e33 | ARYLSULFATASE A (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 5 | LEU P 182GLY P 129GLY P 132GLN P 190LEU P 485 | None | 0.99A | 5l0zB-1e33P:undetectable | 5l0zB-1e33P:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc9 | PHOTOSYSTEM II D1PROTEASE (Tetradesmusobliquus) |
PF03572(Peptidase_S41)PF13180(PDZ_2) | 5 | THR A 394GLY A 431ILE A 312LEU A 377ALA A 378 | None | 1.04A | 5l0zB-1fc9A:2.3 | 5l0zB-1fc9A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | GLY A 199ILE A 216SER A 224LEU A 225ALA A 230 | None | 0.90A | 5l0zB-1gz0A:8.1 | 5l0zB-1gz0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | THR A 174GLY A 196GLY A 201LEU A 225ALA A 230 | None | 0.47A | 5l0zB-1gz0A:8.1 | 5l0zB-1gz0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | THR A 174GLY A 196ILE A 216LEU A 225ALA A 230 | None | 0.64A | 5l0zB-1gz0A:8.1 | 5l0zB-1gz0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2a | HYDROGENASE (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | LEU S 137GLY S 77GLY S 132ILE S 97LEU S 12 | None | 1.01A | 5l0zB-1h2aS:undetectable | 5l0zB-1h2aS:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jal | YCHF PROTEIN (Haemophilusinfluenzae) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 5 | LEU A 22GLY A 101GLY A 6LEU A 276ALA A 272 | None | 1.04A | 5l0zB-1jalA:undetectable | 5l0zB-1jalA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7g | GDP-D-MANNOSE-4,6-DEHYDRATASE (Arabidopsisthaliana) |
PF16363(GDP_Man_Dehyd) | 5 | LEU A 58GLY A 136ILE A 102SER A 97ALA A 143 | None | 0.84A | 5l0zB-1n7gA:2.6 | 5l0zB-1n7gA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q56 | AGRIN (Gallus gallus) |
PF00054(Laminin_G_1) | 5 | THR A 23GLY A 21GLY A 162ILE A 17ALA A 18 | None | 1.04A | 5l0zB-1q56A:undetectable | 5l0zB-1q56A:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r5m | SIR4-INTERACTINGPROTEIN SIF2 (Saccharomycescerevisiae) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 5 | LEU A 383GLY A 399ILE A 416LEU A 426LEU A 437 | None | 1.03A | 5l0zB-1r5mA:undetectable | 5l0zB-1r5mA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 321GLY A 295GLY A 297LEU A 330LEU A 170 | None | 1.04A | 5l0zB-1ulqA:undetectable | 5l0zB-1ulqA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2x | TRNA (GM18)METHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 7 | THR A 99GLY A 122GLY A 127ILE A 142SER A 150LEU A 151ALA A 156 | SAM A 400 (-3.2A)SAM A 400 (-3.2A)SAM A 400 (-3.8A)SAM A 400 (-3.6A)SAM A 400 ( 3.7A)SAM A 400 (-4.0A)SAM A 400 (-3.5A) | 0.53A | 5l0zB-1v2xA:19.3 | 5l0zB-1v2xA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2x | TRNA (GM18)METHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 7 | THR A 99LEU A 101GLY A 122GLY A 127ILE A 142LEU A 151ALA A 156 | SAM A 400 (-3.2A)SAM A 400 ( 4.1A)SAM A 400 (-3.2A)SAM A 400 (-3.8A)SAM A 400 (-3.6A)SAM A 400 (-4.0A)SAM A 400 (-3.5A) | 0.68A | 5l0zB-1v2xA:19.3 | 5l0zB-1v2xA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 5 | LEU A 296GLY A 73GLY A 302LEU A 319ALA A 79 | None | 0.97A | 5l0zB-1wkyA:3.4 | 5l0zB-1wkyA:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x7p | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF00588(SpoU_methylase) | 7 | THR A 210GLY A 232GLY A 237ILE A 252SER A 260LEU A 261ALA A 266 | SAM A 301 (-3.6A)SAM A 301 (-3.2A)SAM A 301 (-3.4A)SAM A 301 (-4.0A)SAM A 301 ( 3.7A)SAM A 301 (-4.1A)SAM A 301 (-3.4A) | 0.65A | 5l0zB-1x7pA:29.0 | 5l0zB-1x7pA:32.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | GLY A 126GLY A 131SER A 154LEU A 155ALA A 160 | GOL A 529 (-4.0A)GOL A 530 (-3.7A)GOL A 529 (-3.5A)NoneGOL A 529 (-3.6A) | 1.04A | 5l0zB-1zjrA:17.8 | 5l0zB-1zjrA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 7 | THR A 103LEU A 105GLY A 126ILE A 146SER A 154LEU A 155ALA A 160 | GOL A 529 (-3.0A)GOL A 530 ( 4.5A)GOL A 529 (-4.0A)NoneGOL A 529 (-3.5A)NoneGOL A 529 (-3.6A) | 0.82A | 5l0zB-1zjrA:17.8 | 5l0zB-1zjrA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g04 | PROBABLEFATTY-ACID-COARACEMASE FAR (Mycobacteriumtuberculosis) |
PF02515(CoA_transf_3) | 5 | GLY A 95ILE A 13LEU A 75LEU A 73ALA A 76 | None | 1.05A | 5l0zB-2g04A:3.2 | 5l0zB-2g04A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ha8 | TAR (HIV-1) RNA LOOPBINDING PROTEIN (Homo sapiens) |
PF00588(SpoU_methylase) | 6 | GLY A 129GLY A 134ILE A 149GLN A 151SER A 157LEU A 158 | SAH A 401 (-3.1A)SAH A 401 (-3.2A)SAH A 401 (-3.8A)SAH A 401 (-3.7A)SAH A 401 ( 3.8A)SAH A 401 (-4.3A) | 0.55A | 5l0zB-2ha8A:21.2 | 5l0zB-2ha8A:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6d | RNAMETHYLTRANSFERASE,TRMH FAMILY (Porphyromonasgingivalis) |
PF00588(SpoU_methylase) | 6 | GLY A 203GLY A 208ILE A 223SER A 236LEU A 237ALA A 242 | None | 0.65A | 5l0zB-2i6dA:8.0 | 5l0zB-2i6dA:31.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6d | RNAMETHYLTRANSFERASE,TRMH FAMILY (Porphyromonasgingivalis) |
PF00588(SpoU_methylase) | 6 | LEU A 181GLY A 203GLY A 208ILE A 223LEU A 237ALA A 242 | None | 0.69A | 5l0zB-2i6dA:8.0 | 5l0zB-2i6dA:31.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | LEU A 554GLY A 331GLY A 914ILE A 549ALA A 338 | None | 1.03A | 5l0zB-2obeA:undetectable | 5l0zB-2obeA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qz6 | BETA-LACTAMASE (Pseudomonasfluorescens) |
PF00144(Beta-lactamase) | 6 | THR A 319GLY A 321GLY A 202ILE A 62LEU A 339ALA A 324 | None | 1.44A | 5l0zB-2qz6A:undetectable | 5l0zB-2qz6A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vml | PHYCOCYANIN ALPHACHAIN (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | LEU A 51GLY A 139ILE A 93LEU A 147ALA A 150 | None | 1.03A | 5l0zB-2vmlA:undetectable | 5l0zB-2vmlA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A 478ILE A 512GLN A 566LEU A 472LEU A 482 | None | 1.03A | 5l0zB-3av6A:undetectable | 5l0zB-3av6A:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcm | UNCHARACTERIZEDPROTEIN TM_1570 (Thermotogamaritima) |
PF09936(Methyltrn_RNA_4) | 6 | THR X 111GLY X 141GLY X 145ILE X 161LEU X 170ALA X 175 | SAM X5452 (-3.9A)SAM X5452 (-3.1A)SAM X5452 (-3.7A)SAM X5452 (-3.7A)SAM X5452 (-4.2A)SAM X5452 (-3.3A) | 0.54A | 5l0zB-3dcmX:5.8 | 5l0zB-3dcmX:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e5y | TRMH FAMILY RNAMETHYLTRANSFERASE (Burkholderiapseudomallei) |
PF00588(SpoU_methylase) | 5 | GLY A 102GLY A 107SER A 132LEU A 133LEU A 135 | None | 0.59A | 5l0zB-3e5yA:13.4 | 5l0zB-3e5yA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAINRESPIRATORY NITRATEREDUCTASE 1 BETACHAIN (Escherichiacoli;Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N)PF13247(Fer4_11)PF14711(Nitr_red_bet_C) | 5 | GLY B 375GLY B 372ILE A 521GLN A 517LEU A 293 | None | 1.02A | 5l0zB-3egwB:undetectable | 5l0zB-3egwB:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 5 | LEU A 112GLY A 145GLY A 96LEU A 149ALA A 152 | None | 0.84A | 5l0zB-3gipA:undetectable | 5l0zB-3gipA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyq | RRNA(ADENOSINE-2'-O-)-METHYLTRANSFERASE (Streptomycescyaneus) |
PF00588(SpoU_methylase)PF04705(TSNR_N) | 5 | GLY A 218GLY A 223ILE A 238SER A 246LEU A 247 | SAM A 270 (-2.9A)NoneSAM A 270 (-3.5A)SAM A 270 (-2.8A)SAM A 270 (-4.4A) | 0.77A | 5l0zB-3gyqA:23.1 | 5l0zB-3gyqA:27.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h14 | AMINOTRANSFERASE,CLASSES I AND II (Ruegeriapomeroyi) |
PF00155(Aminotran_1_2) | 5 | GLY A 102GLY A 99ILE A 198LEU A 106ALA A 107 | None | 0.98A | 5l0zB-3h14A:undetectable | 5l0zB-3h14A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h6e | CARBOHYDRATE KINASE,FGGY (Novosphingobiumaromaticivorans) |
PF00370(FGGY_N) | 5 | LEU A 46GLY A 74GLY A 12ILE A 79GLN A 130 | None | 0.93A | 5l0zB-3h6eA:undetectable | 5l0zB-3h6eA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic6 | PUTATIVE METHYLASEFAMILY PROTEIN (Neisseriagonorrhoeae) |
PF00588(SpoU_methylase) | 6 | GLY A 145GLY A 150ILE A 165LEU A 174LEU A 176ALA A 179 | None | 0.62A | 5l0zB-3ic6A:14.4 | 5l0zB-3ic6A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ife | PEPTIDASE T (Bacillusanthracis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | GLY A 200GLY A 201ILE A 150LEU A 147ALA A 78 | None | 1.00A | 5l0zB-3ifeA:undetectable | 5l0zB-3ifeA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilk | UNCHARACTERIZEDTRNA/RRNAMETHYLTRANSFERASEHI0380 (Haemophilusinfluenzae) |
PF00588(SpoU_methylase) | 8 | THR A 78GLY A 111GLY A 116ILE A 131SER A 139LEU A 140LEU A 142ALA A 145 | EDO A 242 (-3.4A)EDO A 242 (-4.6A)NoneEDO A 243 (-4.0A)NoneNoneEDO A 242 ( 4.5A)EDO A 242 ( 3.7A) | 0.80A | 5l0zB-3ilkA:7.2 | 5l0zB-3ilkA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6k | ESTERASE/LIPASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 94GLY A 88ILE A 71GLN A 73LEU A 100 | None | 1.02A | 5l0zB-3k6kA:2.6 | 5l0zB-3k6kA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8k | ALPHA-AMYLASE, SUSG (Bacteroidesthetaiotaomicron) |
PF00128(Alpha-amylase) | 5 | THR A 502GLY A 536ILE A 462LEU A 515ALA A 516 | None | 1.03A | 5l0zB-3k8kA:undetectable | 5l0zB-3k8kA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kty | PROBABLEMETHYLTRANSFERASE (Bordetellapertussis) |
PF00588(SpoU_methylase) | 5 | GLY A 123GLY A 128ILE A 143LEU A 152ALA A 157 | None | 0.79A | 5l0zB-3ktyA:18.4 | 5l0zB-3ktyA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8u | PUTATIVE RRNAMETHYLASE (Streptococcusmutans) |
PF00588(SpoU_methylase) | 5 | GLY A 117GLY A 122ILE A 138LEU A 148LEU A 150 | None | 0.57A | 5l0zB-3l8uA:8.0 | 5l0zB-3l8uA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8u | PUTATIVE RRNAMETHYLASE (Streptococcusmutans) |
PF00588(SpoU_methylase) | 5 | GLY A 117ILE A 138SER A 147LEU A 148LEU A 150 | None | 0.75A | 5l0zB-3l8uA:8.0 | 5l0zB-3l8uA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n4k | RNAMETHYLTRANSFERASE (Yersinia pestis) |
PF00588(SpoU_methylase) | 6 | GLY A 105GLY A 110ILE A 127SER A 135LEU A 138ALA A 141 | SAH A 201 (-3.1A)SAH A 201 (-3.4A)SAH A 201 (-3.8A)SAH A 201 (-3.3A)SAH A 201 (-4.3A)SAH A 201 ( 4.0A) | 0.44A | 5l0zB-3n4kA:7.6 | 5l0zB-3n4kA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nra | ASPARTATEAMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00155(Aminotran_1_2) | 5 | GLY A 112GLY A 109ILE A 215LEU A 116ALA A 117 | NoneLLP A 252 ( 3.5A)NoneNoneNone | 1.03A | 5l0zB-3nraA:undetectable | 5l0zB-3nraA:26.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3onp | TRNA/RRNAMETHYLTRANSFERASE(SPOU) (Rhodobactersphaeroides) |
PF00588(SpoU_methylase) | 5 | THR A 80GLY A 116GLY A 121LEU A 145LEU A 147 | BME A 251 ( 4.4A)ACY A 250 (-4.5A)ACY A 250 (-3.5A)BME A 251 ( 3.9A)ACY A 250 ( 4.5A) | 0.77A | 5l0zB-3onpA:7.0 | 5l0zB-3onpA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pm9 | PUTATIVEOXIDOREDUCTASE (Rhodopseudomonaspalustris) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | LEU A 258GLY A 389ILE A 249LEU A 246LEU A 244 | None | 1.00A | 5l0zB-3pm9A:undetectable | 5l0zB-3pm9A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxb | PUTATIVE XYLOSEISOMERASE (Rhodospirillumrubrum) |
PF01261(AP_endonuc_2) | 5 | THR A 70GLY A 113SER A 76LEU A 97ALA A 100 | None | 1.03A | 5l0zB-3qxbA:undetectable | 5l0zB-3qxbA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0o | CARNITINYL-COADEHYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | GLY A 117GLY A 116GLN A 158LEU A 121ALA A 124 | NoneNoneNoneNoneEDO A 270 (-4.1A) | 1.04A | 5l0zB-3r0oA:undetectable | 5l0zB-3r0oA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3c | 4-HYDROXYBENZOYL-COATHIOESTERASE (Arthrobactersp.) |
PF03061(4HBT) | 5 | LEU A 15GLY A 35GLY A 32LEU A 75ALA A 48 | None | 1.02A | 5l0zB-3r3cA:undetectable | 5l0zB-3r3cA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wz2 | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09754(PAC2) | 5 | GLY A 27GLY A 180ILE A 153LEU A 175ALA A 114 | None | 0.99A | 5l0zB-3wz2A:undetectable | 5l0zB-3wz2A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x27 | CUCUMOPINE SYNTHASE (Marinactinosporathermotolerans) |
no annotation | 5 | LEU A 288GLY A 215ILE A 56LEU A 61LEU A 85 | None | 1.05A | 5l0zB-3x27A:undetectable | 5l0zB-3x27A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zid | TUBULIN/FTSZ, GTPASE (Methanothrixthermoacetophila) |
PF00091(Tubulin) | 5 | LEU A 7GLY A 10GLY A 13ILE A 93LEU A 67 | NoneGDP A 999 (-3.5A)NoneNoneNone | 1.04A | 5l0zB-3zidA:undetectable | 5l0zB-3zidA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | HEXON PROTEIN (BovinemastadenovirusB) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | LEU A 536GLY A 317GLY A 893ILE A 531ALA A 324 | None | 1.05A | 5l0zB-3zifA:undetectable | 5l0zB-3zifA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cng | SPOU RRNA METHYLASE (Sulfolobusacidocaldarius) |
PF00588(SpoU_methylase) | 7 | THR A 77GLY A 111GLY A 116ILE A 131LEU A 140LEU A 142ALA A 145 | SAH A1157 (-3.6A)SAH A1157 (-3.1A)SAH A1157 ( 3.2A)SAH A1157 (-3.6A)SAH A1157 (-3.8A)SAH A1157 ( 4.4A)SAH A1157 ( 3.7A) | 0.30A | 5l0zB-4cngA:7.3 | 5l0zB-4cngA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | LEU A 29GLY A 21ILE A 41SER A 115LEU A 114 | NoneNoneHEM A1374 ( 4.0A)NoneNone | 0.98A | 5l0zB-4czpA:undetectable | 5l0zB-4czpA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fh8 | ACEPRX-1 (Ancylostomaceylanicum) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 5 | THR A 75GLY A 121ILE A 109GLN A 108ALA A 110 | None | 1.02A | 5l0zB-4fh8A:3.2 | 5l0zB-4fh8A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv6 | TRANSCRIPTIONALREGULATOR MNTR (Bacillussubtilis) |
PF01325(Fe_dep_repress)PF02742(Fe_dep_repr_C) | 5 | GLY A 66ILE A 28GLN A 12LEU A 16ALA A 23 | None | 1.01A | 5l0zB-4hv6A:undetectable | 5l0zB-4hv6A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihe | THNT PROTEIN (Streptomycescattleya) |
PF03576(Peptidase_S58) | 5 | THR A 101GLY A 56GLY A 183LEU A 160ALA A 110 | None | 0.81A | 5l0zB-4iheA:undetectable | 5l0zB-4iheA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 5 | THR A 207LEU A 211GLY A 203GLY A 202LEU A 116 | None | 1.00A | 5l0zB-4injA:2.2 | 5l0zB-4injA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdz | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Escherichiacoli) |
PF00588(SpoU_methylase) | 5 | GLY A 100GLY A 105ILE A 122LEU A 133ALA A 136 | None | 0.52A | 5l0zB-4kdzA:18.8 | 5l0zB-4kdzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw6 | PEROXIREDOXIN-1 (Ancylostomaceylanicum) |
PF00578(AhpC-TSA) | 5 | THR A 75GLY A 121ILE A 109GLN A 108ALA A 110 | None | 1.00A | 5l0zB-4kw6A:3.1 | 5l0zB-4kw6A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9u | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Thermusthermophilus) |
PF02233(PNTB) | 5 | LEU B 196GLY B 131GLY B 191LEU B 133ALA B 137 | None | 1.05A | 5l0zB-4o9uB:2.3 | 5l0zB-4o9uB:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofz | TREHALOSE-PHOSPHATASE (Brugia malayi) |
no annotation | 5 | LEU A 413GLY A 401GLY A 399ILE A 248ALA A 250 | None | 0.93A | 5l0zB-4ofzA:undetectable | 5l0zB-4ofzA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pd4 | CYTOCHROME B (Saccharomycescerevisiae) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 6 | GLY C 337GLY C 340ILE C 354GLN C 353SER C 284ALA C 355 | None | 1.38A | 5l0zB-4pd4C:undetectable | 5l0zB-4pd4C:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pjs | PENTATRICOPEPTIDEREPEAT PROTEIN (unidentified) |
PF13041(PPR_2) | 5 | THR A 218GLY A 222LEU A 188LEU A 194ALA A 197 | None | 1.04A | 5l0zB-4pjsA:undetectable | 5l0zB-4pjsA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzk | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Bacillusanthracis) |
PF00588(SpoU_methylase) | 6 | GLY A 104GLY A 109ILE A 125SER A 133LEU A 134LEU A 136 | SAH A 201 (-3.1A)SAH A 201 (-3.3A)SAH A 201 (-3.9A)SAH A 201 ( 3.8A)SAH A 201 (-4.2A)SAH A 201 ( 4.3A) | 0.45A | 5l0zB-4pzkA:7.8 | 5l0zB-4pzkA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6r | SPHINGOSINE-1-PHOSPHATE LYASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | THR A 519GLY A 521ILE A 511GLN A 510LEU A 466 | GOL A 902 (-4.5A)NoneGOL A 902 ( 4.7A)NoneGOL A 902 ( 4.6A) | 0.97A | 5l0zB-4q6rA:undetectable | 5l0zB-4q6rA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rg1 | C9ORF114 (Homo sapiens) |
PF02598(Methyltrn_RNA_3) | 5 | THR A 289GLY A 312GLY A 316GLN A 346ALA A 356 | SAH A 401 (-3.8A)SAH A 401 (-3.1A)SAH A 401 (-3.3A)SAH A 401 (-3.8A)SAH A 401 (-3.4A) | 0.80A | 5l0zB-4rg1A:4.5 | 5l0zB-4rg1A:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9i | PERIPLASMIC [NIFE]HYDROGENASE SMALLSUBUNIT (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | LEU S 137GLY S 77GLY S 132ILE S 97LEU S 12 | None | 1.05A | 5l0zB-4u9iS:undetectable | 5l0zB-4u9iS:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wuj | GLYCOSIDE HYDROLASEFAMILY 15, CELLULOSESIGNALING ASSOCIATEDPROTEIN ENVOY (Trichodermareesei) |
PF13426(PAS_9) | 5 | LEU A 138GLY A 202ILE A 130LEU A 100ALA A 115 | FMN A5201 (-3.7A)FMN A5201 (-3.0A)NoneNoneNone | 0.82A | 5l0zB-4wujA:undetectable | 5l0zB-4wujA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 7 | THR A 79GLY A 114GLY A 119ILE A 134LEU A 143LEU A 145ALA A 148 | SAH A 301 (-3.4A)SAH A 301 (-2.9A)SAH A 301 (-3.2A)SAH A 301 (-3.9A)SAH A 301 (-3.8A)SAH A 301 ( 4.5A)SAH A 301 (-3.6A) | 0.44A | 5l0zB-4xboA:7.0 | 5l0zB-4xboA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 7 | THR A 79GLY A 114GLY A 119ILE A 134SER A 142LEU A 143ALA A 148 | SAH A 301 (-3.4A)SAH A 301 (-2.9A)SAH A 301 (-3.2A)SAH A 301 (-3.9A)SAH A 301 (-3.4A)SAH A 301 (-3.8A)SAH A 301 (-3.6A) | 0.64A | 5l0zB-4xboA:7.0 | 5l0zB-4xboA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xe7 | UNCHARACTERIZEDPROTEIN (Bacillusthuringiensis) |
no annotation | 5 | THR A 197GLY A 152GLY A 153SER A 204ALA A 410 | None | 1.01A | 5l0zB-4xe7A:undetectable | 5l0zB-4xe7A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhp | PARM HYBRID FUSIONPROTEIN (Bacillusthuringiensis) |
no annotation | 5 | GLY A 152GLY A 153SER A 205LEU A 207ALA A 410 | None | 1.04A | 5l0zB-4xhpA:undetectable | 5l0zB-4xhpA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5an3 | SUPPRESSOR OFKINETOCHORE PROTEIN1 (Saccharomycescerevisiae) |
PF03931(Skp1_POZ) | 5 | LEU D 8ILE D 22SER D 26LEU D 146ALA D 94 | None | 1.04A | 5l0zB-5an3D:undetectable | 5l0zB-5an3D:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz4 | BETA-KETOTHIOLASE (Mycolicibacteriumsmegmatis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 324GLY A 298GLY A 300LEU A 333LEU A 170 | None | 1.01A | 5l0zB-5bz4A:undetectable | 5l0zB-5bz4A:25.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5co4 | PUTATIVE TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 7 | GLY B 101GLY B 106ILE B 120SER B 128LEU B 129LEU B 131ALA B 134 | MTA B 401 (-3.2A)MTA B 401 (-3.2A)MTA B 401 (-3.7A)MTA B 401 ( 3.9A)MTA B 401 (-4.3A)MTA B 401 ( 4.2A)MTA B 401 (-3.5A) | 0.44A | 5l0zB-5co4B:8.0 | 5l0zB-5co4B:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez7 | FLAVOENZYME PA4991 (Pseudomonasaeruginosa) |
PF01266(DAO) | 5 | LEU A 159GLY A 18GLY A 15LEU A 166ALA A 23 | NoneNoneFAD A 401 (-3.3A)NoneNone | 0.99A | 5l0zB-5ez7A:4.3 | 5l0zB-5ez7A:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8z | PLASMA KALLIKREINLIGHT CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | LEU A 155GLY A 44GLY A 197ILE A 70LEU A 33 | SO4 A 302 (-4.7A)NoneNoneNoneNone | 1.00A | 5l0zB-5f8zA:undetectable | 5l0zB-5f8zA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmb | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Pseudomonasaeruginosa) |
PF00588(SpoU_methylase) | 8 | THR A 79GLY A 115GLY A 120ILE A 135SER A 143LEU A 144LEU A 146ALA A 149 | None | 0.65A | 5l0zB-5gmbA:7.2 | 5l0zB-5gmbA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gra | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Zymomonasmobilis) |
PF00588(SpoU_methylase) | 5 | THR A 81GLY A 114GLY A 119LEU A 145ALA A 148 | None | 0.62A | 5l0zB-5graA:6.7 | 5l0zB-5graA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gra | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Zymomonasmobilis) |
PF00588(SpoU_methylase) | 5 | THR A 81GLY A 114LEU A 143LEU A 145ALA A 148 | None | 0.65A | 5l0zB-5graA:6.7 | 5l0zB-5graA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gui | CHAPERONE PROTEINCLPC1, CHLOROPLASTIC (Arabidopsisthaliana) |
PF02861(Clp_N) | 5 | GLY A 132GLY A 134ILE A 106SER A 198LEU A 201 | NoneNoneNonePO4 A 301 (-2.5A)None | 0.92A | 5l0zB-5guiA:undetectable | 5l0zB-5guiA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gvt | PLASMA KALLIKREIN (Mus musculus) |
no annotation | 5 | LEU A 155GLY A 44GLY A 197ILE A 70LEU A 33 | None | 0.99A | 5l0zB-5gvtA:undetectable | 5l0zB-5gvtA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l0z | PROBABLE RNAMETHYLTRANSFERASE,TRMH FAMILY (Sinorhizobiummeliloti) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 9 | THR A 212GLY A 235GLY A 240ILE A 255GLN A 257SER A 263LEU A 264LEU A 266ALA A 269 | SAM A 304 (-3.7A)SAM A 304 (-3.2A)SAM A 304 (-3.4A)SAM A 304 (-3.9A)SAM A 304 (-4.0A)SAM A 304 (-3.1A)SAM A 304 (-3.8A)SO4 A 303 (-4.4A)SAM A 304 (-3.6A) | 0.47A | 5l0zB-5l0zA:39.2 | 5l0zB-5l0zA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l0z | PROBABLE RNAMETHYLTRANSFERASE,TRMH FAMILY (Sinorhizobiummeliloti) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 8 | THR A 212LEU A 214GLY A 235GLY A 240ILE A 255GLN A 257LEU A 266ALA A 269 | SAM A 304 (-3.7A)SAM A 304 (-4.3A)SAM A 304 (-3.2A)SAM A 304 (-3.4A)SAM A 304 (-3.9A)SAM A 304 (-4.0A)SO4 A 303 (-4.4A)SAM A 304 (-3.6A) | 0.80A | 5l0zB-5l0zA:39.2 | 5l0zB-5l0zA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l38 | MSM0272 - RMMMICROCOMPARTMENTSHELL PROTEIN (Mycolicibacteriumsmegmatis) |
PF00936(BMC) | 5 | GLY A 13GLY A 41ILE A 9LEU A 71ALA A 65 | None | 1.02A | 5l0zB-5l38A:undetectable | 5l0zB-5l38A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | LEU A 573GLY A 349GLY A 933ILE A 568ALA A 356 | None | 1.01A | 5l0zB-5ldnA:undetectable | 5l0zB-5ldnA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldr | BETA-D-GALACTOSIDASE (Paracoccus sp.32d) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | LEU B 647GLY B 651ILE B 712LEU B 703ALA B 684 | None | 1.05A | 5l0zB-5ldrB:undetectable | 5l0zB-5ldrB:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nva | PUTATIVESODIUM:SOLUTESYMPORTER (Proteusmirabilis) |
no annotation | 5 | GLY A 173GLY A 177ILE A 167SER A 345LEU A 348 | NoneNoneNone NA A 502 (-2.3A)None | 0.90A | 5l0zB-5nvaA:undetectable | 5l0zB-5nvaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nva | PUTATIVESODIUM:SOLUTESYMPORTER (Proteusmirabilis) |
no annotation | 5 | GLY A 174GLY A 177ILE A 167SER A 345LEU A 348 | NoneNoneNone NA A 502 (-2.3A)None | 0.99A | 5l0zB-5nvaA:undetectable | 5l0zB-5nvaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 5 | LEU A 356GLY A 202GLY A 204ILE A 198LEU A 158 | NoneNoneNoneGOL A 606 (-4.5A)None | 0.94A | 5l0zB-5oc1A:undetectable | 5l0zB-5oc1A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u24 | PUTATIVEAMINOTRANSFERASE (Campylobacterjejuni) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 83ILE A 85LEU A 89LEU A 62ALA A 86 | NoneNoneNoneNone7SG A 402 ( 3.7A) | 1.03A | 5l0zB-5u24A:undetectable | 5l0zB-5u24A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5usd | PEPTIDASE S66 (Bacillusanthracis) |
PF02016(Peptidase_S66) | 5 | THR A 207LEU A 211GLY A 203GLY A 202LEU A 116 | None | 0.79A | 5l0zB-5usdA:2.0 | 5l0zB-5usdA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v41 | POLYKETIDE SYNTHASEPKS13 (TERMINATIONPOLYKETIDE SYNTHASE) (Mycobacteriumtuberculosis) |
PF00975(Thioesterase) | 5 | LEU A1657GLY A1531GLY A1536ILE A1695ALA A1702 | None | 1.01A | 5l0zB-5v41A:3.1 | 5l0zB-5v41A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8c | TRANSCRIPTIONALREGULATOR (Actinomycesoris) |
no annotation | 5 | THR A 174LEU A 189GLY A 170ILE A 132ALA A 129 | None | 1.01A | 5l0zB-5v8cA:undetectable | 5l0zB-5v8cA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb7 | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
no annotation | 5 | THR A 312GLY A 316ILE A 292SER A 283LEU A 327 | None | 0.88A | 5l0zB-5xb7A:undetectable | 5l0zB-5xb7A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0u | NEOPULLULANASE 1 (Thermoactinomycesvulgaris) |
no annotation | 5 | GLY A 510ILE A 428LEU A 489LEU A 491ALA A 490 | None | 1.02A | 5l0zB-5z0uA:3.3 | 5l0zB-5z0uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ams | BETA SLIDING CLAMP (Pseudomonasaeruginosa) |
no annotation | 5 | LEU A 160GLY A 157LEU A 204LEU A 202ALA A 205 | None | 1.02A | 5l0zB-6amsA:undetectable | 5l0zB-6amsA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gt1 | SERINE/THREONINE-PROTEIN KINASE NEK7 (Homo sapiens) |
no annotation | 5 | GLY A 178ILE A 40LEU A 113LEU A 111ALA A 61 | NoneF9N A 401 (-4.0A)F9N A 401 ( 4.9A)F9N A 401 ( 4.6A)F9N A 401 ( 4.2A) | 0.96A | 5l0zB-6gt1A:undetectable | 5l0zB-6gt1A:undetectable |