SIMILAR PATTERNS OF AMINO ACIDS FOR 5L0Z_B_SAMB304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)


(Amycolatopsis
mediterranei)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 181
GLY A  62
GLY A 196
ILE A 179
ALA A  69
None
PLP  A 389 (-3.5A)
None
None
None
0.94A 5l0zB-1b9hA:
undetectable
5l0zB-1b9hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)


(Oryctolagus
cuniculus)
PF00464
(SHMT)
5 LEU A 402
GLY A 389
GLN A4061
LEU A4111
ALA A 408
None
1.03A 5l0zB-1cj0A:
undetectable
5l0zB-1cj0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
5 LEU P 182
GLY P 129
GLY P 132
GLN P 190
LEU P 485
None
0.99A 5l0zB-1e33P:
undetectable
5l0zB-1e33P:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE


(Tetradesmus
obliquus)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2)
5 THR A 394
GLY A 431
ILE A 312
LEU A 377
ALA A 378
None
1.04A 5l0zB-1fc9A:
2.3
5l0zB-1fc9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 GLY A 199
ILE A 216
SER A 224
LEU A 225
ALA A 230
None
0.90A 5l0zB-1gz0A:
8.1
5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 THR A 174
GLY A 196
GLY A 201
LEU A 225
ALA A 230
None
0.47A 5l0zB-1gz0A:
8.1
5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 THR A 174
GLY A 196
ILE A 216
LEU A 225
ALA A 230
None
0.64A 5l0zB-1gz0A:
8.1
5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2a HYDROGENASE

(Desulfovibrio
vulgaris)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 LEU S 137
GLY S  77
GLY S 132
ILE S  97
LEU S  12
None
1.01A 5l0zB-1h2aS:
undetectable
5l0zB-1h2aS:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 LEU A  22
GLY A 101
GLY A   6
LEU A 276
ALA A 272
None
1.04A 5l0zB-1jalA:
undetectable
5l0zB-1jalA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE


(Arabidopsis
thaliana)
PF16363
(GDP_Man_Dehyd)
5 LEU A  58
GLY A 136
ILE A 102
SER A  97
ALA A 143
None
0.84A 5l0zB-1n7gA:
2.6
5l0zB-1n7gA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus)
PF00054
(Laminin_G_1)
5 THR A  23
GLY A  21
GLY A 162
ILE A  17
ALA A  18
None
1.04A 5l0zB-1q56A:
undetectable
5l0zB-1q56A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
5 LEU A 383
GLY A 399
ILE A 416
LEU A 426
LEU A 437
None
1.03A 5l0zB-1r5mA:
undetectable
5l0zB-1r5mA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 321
GLY A 295
GLY A 297
LEU A 330
LEU A 170
None
1.04A 5l0zB-1ulqA:
undetectable
5l0zB-1ulqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
7 THR A  99
GLY A 122
GLY A 127
ILE A 142
SER A 150
LEU A 151
ALA A 156
SAM  A 400 (-3.2A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.8A)
SAM  A 400 (-3.6A)
SAM  A 400 ( 3.7A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.5A)
0.53A 5l0zB-1v2xA:
19.3
5l0zB-1v2xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
7 THR A  99
LEU A 101
GLY A 122
GLY A 127
ILE A 142
LEU A 151
ALA A 156
SAM  A 400 (-3.2A)
SAM  A 400 ( 4.1A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.8A)
SAM  A 400 (-3.6A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.5A)
0.68A 5l0zB-1v2xA:
19.3
5l0zB-1v2xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE


(Bacillus sp.
JAMB-602)
PF00150
(Cellulase)
5 LEU A 296
GLY A  73
GLY A 302
LEU A 319
ALA A  79
None
0.97A 5l0zB-1wkyA:
3.4
5l0zB-1wkyA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x7p RRNA
METHYLTRANSFERASE


(Streptomyces
viridochromogenes)
PF00588
(SpoU_methylase)
7 THR A 210
GLY A 232
GLY A 237
ILE A 252
SER A 260
LEU A 261
ALA A 266
SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
0.65A 5l0zB-1x7pA:
29.0
5l0zB-1x7pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
5 GLY A 126
GLY A 131
SER A 154
LEU A 155
ALA A 160
GOL  A 529 (-4.0A)
GOL  A 530 (-3.7A)
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.6A)
1.04A 5l0zB-1zjrA:
17.8
5l0zB-1zjrA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
7 THR A 103
LEU A 105
GLY A 126
ILE A 146
SER A 154
LEU A 155
ALA A 160
GOL  A 529 (-3.0A)
GOL  A 530 ( 4.5A)
GOL  A 529 (-4.0A)
None
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.6A)
0.82A 5l0zB-1zjrA:
17.8
5l0zB-1zjrA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 GLY A  95
ILE A  13
LEU A  75
LEU A  73
ALA A  76
None
1.05A 5l0zB-2g04A:
3.2
5l0zB-2g04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN


(Homo sapiens)
PF00588
(SpoU_methylase)
6 GLY A 129
GLY A 134
ILE A 149
GLN A 151
SER A 157
LEU A 158
SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
0.55A 5l0zB-2ha8A:
21.2
5l0zB-2ha8A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Porphyromonas
gingivalis)
PF00588
(SpoU_methylase)
6 GLY A 203
GLY A 208
ILE A 223
SER A 236
LEU A 237
ALA A 242
None
0.65A 5l0zB-2i6dA:
8.0
5l0zB-2i6dA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Porphyromonas
gingivalis)
PF00588
(SpoU_methylase)
6 LEU A 181
GLY A 203
GLY A 208
ILE A 223
LEU A 237
ALA A 242
None
0.69A 5l0zB-2i6dA:
8.0
5l0zB-2i6dA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 LEU A 554
GLY A 331
GLY A 914
ILE A 549
ALA A 338
None
1.03A 5l0zB-2obeA:
undetectable
5l0zB-2obeA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens)
PF00144
(Beta-lactamase)
6 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
None
1.44A 5l0zB-2qz6A:
undetectable
5l0zB-2qz6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN


(Gloeobacter
violaceus)
PF00502
(Phycobilisome)
5 LEU A  51
GLY A 139
ILE A  93
LEU A 147
ALA A 150
None
1.03A 5l0zB-2vmlA:
undetectable
5l0zB-2vmlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 GLY A 478
ILE A 512
GLN A 566
LEU A 472
LEU A 482
None
1.03A 5l0zB-3av6A:
undetectable
5l0zB-3av6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570


(Thermotoga
maritima)
PF09936
(Methyltrn_RNA_4)
6 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
0.54A 5l0zB-3dcmX:
5.8
5l0zB-3dcmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5y TRMH FAMILY RNA
METHYLTRANSFERASE


(Burkholderia
pseudomallei)
PF00588
(SpoU_methylase)
5 GLY A 102
GLY A 107
SER A 132
LEU A 133
LEU A 135
None
0.59A 5l0zB-3e5yA:
13.4
5l0zB-3e5yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN


(Escherichia
coli;
Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C)
5 GLY B 375
GLY B 372
ILE A 521
GLN A 517
LEU A 293
None
1.02A 5l0zB-3egwB:
undetectable
5l0zB-3egwB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE


(Bordetella
bronchiseptica)
PF07969
(Amidohydro_3)
5 LEU A 112
GLY A 145
GLY A  96
LEU A 149
ALA A 152
None
0.84A 5l0zB-3gipA:
undetectable
5l0zB-3gipA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE


(Streptomyces
cyaneus)
PF00588
(SpoU_methylase)
PF04705
(TSNR_N)
5 GLY A 218
GLY A 223
ILE A 238
SER A 246
LEU A 247
SAM  A 270 (-2.9A)
None
SAM  A 270 (-3.5A)
SAM  A 270 (-2.8A)
SAM  A 270 (-4.4A)
0.77A 5l0zB-3gyqA:
23.1
5l0zB-3gyqA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II


(Ruegeria
pomeroyi)
PF00155
(Aminotran_1_2)
5 GLY A 102
GLY A  99
ILE A 198
LEU A 106
ALA A 107
None
0.98A 5l0zB-3h14A:
undetectable
5l0zB-3h14A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY


(Novosphingobium
aromaticivorans)
PF00370
(FGGY_N)
5 LEU A  46
GLY A  74
GLY A  12
ILE A  79
GLN A 130
None
0.93A 5l0zB-3h6eA:
undetectable
5l0zB-3h6eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN


(Neisseria
gonorrhoeae)
PF00588
(SpoU_methylase)
6 GLY A 145
GLY A 150
ILE A 165
LEU A 174
LEU A 176
ALA A 179
None
0.62A 5l0zB-3ic6A:
14.4
5l0zB-3ic6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A 200
GLY A 201
ILE A 150
LEU A 147
ALA A  78
None
1.00A 5l0zB-3ifeA:
undetectable
5l0zB-3ifeA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilk UNCHARACTERIZED
TRNA/RRNA
METHYLTRANSFERASE
HI0380


(Haemophilus
influenzae)
PF00588
(SpoU_methylase)
8 THR A  78
GLY A 111
GLY A 116
ILE A 131
SER A 139
LEU A 140
LEU A 142
ALA A 145
EDO  A 242 (-3.4A)
EDO  A 242 (-4.6A)
None
EDO  A 243 (-4.0A)
None
None
EDO  A 242 ( 4.5A)
EDO  A 242 ( 3.7A)
0.80A 5l0zB-3ilkA:
7.2
5l0zB-3ilkA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A  94
GLY A  88
ILE A  71
GLN A  73
LEU A 100
None
1.02A 5l0zB-3k6kA:
2.6
5l0zB-3k6kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron)
PF00128
(Alpha-amylase)
5 THR A 502
GLY A 536
ILE A 462
LEU A 515
ALA A 516
None
1.03A 5l0zB-3k8kA:
undetectable
5l0zB-3k8kA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE


(Bordetella
pertussis)
PF00588
(SpoU_methylase)
5 GLY A 123
GLY A 128
ILE A 143
LEU A 152
ALA A 157
None
0.79A 5l0zB-3ktyA:
18.4
5l0zB-3ktyA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE


(Streptococcus
mutans)
PF00588
(SpoU_methylase)
5 GLY A 117
GLY A 122
ILE A 138
LEU A 148
LEU A 150
None
0.57A 5l0zB-3l8uA:
8.0
5l0zB-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE


(Streptococcus
mutans)
PF00588
(SpoU_methylase)
5 GLY A 117
ILE A 138
SER A 147
LEU A 148
LEU A 150
None
0.75A 5l0zB-3l8uA:
8.0
5l0zB-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE


(Yersinia pestis)
PF00588
(SpoU_methylase)
6 GLY A 105
GLY A 110
ILE A 127
SER A 135
LEU A 138
ALA A 141
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.3A)
SAH  A 201 (-4.3A)
SAH  A 201 ( 4.0A)
0.44A 5l0zB-3n4kA:
7.6
5l0zB-3n4kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE


(Rhodobacter
sphaeroides)
PF00155
(Aminotran_1_2)
5 GLY A 112
GLY A 109
ILE A 215
LEU A 116
ALA A 117
None
LLP  A 252 ( 3.5A)
None
None
None
1.03A 5l0zB-3nraA:
undetectable
5l0zB-3nraA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)


(Rhodobacter
sphaeroides)
PF00588
(SpoU_methylase)
5 THR A  80
GLY A 116
GLY A 121
LEU A 145
LEU A 147
BME  A 251 ( 4.4A)
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
ACY  A 250 ( 4.5A)
0.77A 5l0zB-3onpA:
7.0
5l0zB-3onpA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE


(Rhodopseudomonas
palustris)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 LEU A 258
GLY A 389
ILE A 249
LEU A 246
LEU A 244
None
1.00A 5l0zB-3pm9A:
undetectable
5l0zB-3pm9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE


(Rhodospirillum
rubrum)
PF01261
(AP_endonuc_2)
5 THR A  70
GLY A 113
SER A  76
LEU A  97
ALA A 100
None
1.03A 5l0zB-3qxbA:
undetectable
5l0zB-3qxbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 GLY A 117
GLY A 116
GLN A 158
LEU A 121
ALA A 124
None
None
None
None
EDO  A 270 (-4.1A)
1.04A 5l0zB-3r0oA:
undetectable
5l0zB-3r0oA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3c 4-HYDROXYBENZOYL-COA
THIOESTERASE


(Arthrobacter
sp.)
PF03061
(4HBT)
5 LEU A  15
GLY A  35
GLY A  32
LEU A  75
ALA A  48
None
1.02A 5l0zB-3r3cA:
undetectable
5l0zB-3r3cA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09754
(PAC2)
5 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
None
0.99A 5l0zB-3wz2A:
undetectable
5l0zB-3wz2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans)
no annotation 5 LEU A 288
GLY A 215
ILE A  56
LEU A  61
LEU A  85
None
1.05A 5l0zB-3x27A:
undetectable
5l0zB-3x27A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila)
PF00091
(Tubulin)
5 LEU A   7
GLY A  10
GLY A  13
ILE A  93
LEU A  67
None
GDP  A 999 (-3.5A)
None
None
None
1.04A 5l0zB-3zidA:
undetectable
5l0zB-3zidA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 LEU A 536
GLY A 317
GLY A 893
ILE A 531
ALA A 324
None
1.05A 5l0zB-3zifA:
undetectable
5l0zB-3zifA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius)
PF00588
(SpoU_methylase)
7 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
LEU A 142
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 4.4A)
SAH  A1157 ( 3.7A)
0.30A 5l0zB-4cngA:
7.3
5l0zB-4cngA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 LEU A  29
GLY A  21
ILE A  41
SER A 115
LEU A 114
None
None
HEM  A1374 ( 4.0A)
None
None
0.98A 5l0zB-4czpA:
undetectable
5l0zB-4czpA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fh8 ACEPRX-1

(Ancylostoma
ceylanicum)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
None
1.02A 5l0zB-4fh8A:
3.2
5l0zB-4fh8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv6 TRANSCRIPTIONAL
REGULATOR MNTR


(Bacillus
subtilis)
PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
5 GLY A  66
ILE A  28
GLN A  12
LEU A  16
ALA A  23
None
1.01A 5l0zB-4hv6A:
undetectable
5l0zB-4hv6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya)
PF03576
(Peptidase_S58)
5 THR A 101
GLY A  56
GLY A 183
LEU A 160
ALA A 110
None
0.81A 5l0zB-4iheA:
undetectable
5l0zB-4iheA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes)
PF02016
(Peptidase_S66)
5 THR A 207
LEU A 211
GLY A 203
GLY A 202
LEU A 116
None
1.00A 5l0zB-4injA:
2.2
5l0zB-4injA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Escherichia
coli)
PF00588
(SpoU_methylase)
5 GLY A 100
GLY A 105
ILE A 122
LEU A 133
ALA A 136
None
0.52A 5l0zB-4kdzA:
18.8
5l0zB-4kdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum)
PF00578
(AhpC-TSA)
5 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
None
1.00A 5l0zB-4kw6A:
3.1
5l0zB-4kw6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA


(Thermus
thermophilus)
PF02233
(PNTB)
5 LEU B 196
GLY B 131
GLY B 191
LEU B 133
ALA B 137
None
1.05A 5l0zB-4o9uB:
2.3
5l0zB-4o9uB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E


(Brugia malayi)
no annotation 5 LEU A 413
GLY A 401
GLY A 399
ILE A 248
ALA A 250
None
0.93A 5l0zB-4ofzA:
undetectable
5l0zB-4ofzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
6 GLY C 337
GLY C 340
ILE C 354
GLN C 353
SER C 284
ALA C 355
None
1.38A 5l0zB-4pd4C:
undetectable
5l0zB-4pd4C:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pjs PENTATRICOPEPTIDE
REPEAT PROTEIN


(unidentified)
PF13041
(PPR_2)
5 THR A 218
GLY A 222
LEU A 188
LEU A 194
ALA A 197
None
1.04A 5l0zB-4pjsA:
undetectable
5l0zB-4pjsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Bacillus
anthracis)
PF00588
(SpoU_methylase)
6 GLY A 104
GLY A 109
ILE A 125
SER A 133
LEU A 134
LEU A 136
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
SAH  A 201 ( 4.3A)
0.45A 5l0zB-4pzkA:
7.8
5l0zB-4pzkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
5 THR A 519
GLY A 521
ILE A 511
GLN A 510
LEU A 466
GOL  A 902 (-4.5A)
None
GOL  A 902 ( 4.7A)
None
GOL  A 902 ( 4.6A)
0.97A 5l0zB-4q6rA:
undetectable
5l0zB-4q6rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens)
PF02598
(Methyltrn_RNA_3)
5 THR A 289
GLY A 312
GLY A 316
GLN A 346
ALA A 356
SAH  A 401 (-3.8A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.4A)
0.80A 5l0zB-4rg1A:
4.5
5l0zB-4rg1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT


(Desulfovibrio
vulgaris)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 LEU S 137
GLY S  77
GLY S 132
ILE S  97
LEU S  12
None
1.05A 5l0zB-4u9iS:
undetectable
5l0zB-4u9iS:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY


(Trichoderma
reesei)
PF13426
(PAS_9)
5 LEU A 138
GLY A 202
ILE A 130
LEU A 100
ALA A 115
FMN  A5201 (-3.7A)
FMN  A5201 (-3.0A)
None
None
None
0.82A 5l0zB-4wujA:
undetectable
5l0zB-4wujA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
7 THR A  79
GLY A 114
GLY A 119
ILE A 134
LEU A 143
LEU A 145
ALA A 148
SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.6A)
0.44A 5l0zB-4xboA:
7.0
5l0zB-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
7 THR A  79
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
ALA A 148
SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
0.64A 5l0zB-4xboA:
7.0
5l0zB-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN


(Bacillus
thuringiensis)
no annotation 5 THR A 197
GLY A 152
GLY A 153
SER A 204
ALA A 410
None
1.01A 5l0zB-4xe7A:
undetectable
5l0zB-4xe7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN


(Bacillus
thuringiensis)
no annotation 5 GLY A 152
GLY A 153
SER A 205
LEU A 207
ALA A 410
None
1.04A 5l0zB-4xhpA:
undetectable
5l0zB-4xhpA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an3 SUPPRESSOR OF
KINETOCHORE PROTEIN
1


(Saccharomyces
cerevisiae)
PF03931
(Skp1_POZ)
5 LEU D   8
ILE D  22
SER D  26
LEU D 146
ALA D  94
None
1.04A 5l0zB-5an3D:
undetectable
5l0zB-5an3D:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 324
GLY A 298
GLY A 300
LEU A 333
LEU A 170
None
1.01A 5l0zB-5bz4A:
undetectable
5l0zB-5bz4A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 7 GLY B 101
GLY B 106
ILE B 120
SER B 128
LEU B 129
LEU B 131
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 ( 4.2A)
MTA  B 401 (-3.5A)
0.44A 5l0zB-5co4B:
8.0
5l0zB-5co4B:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa)
PF01266
(DAO)
5 LEU A 159
GLY A  18
GLY A  15
LEU A 166
ALA A  23
None
None
FAD  A 401 (-3.3A)
None
None
0.99A 5l0zB-5ez7A:
4.3
5l0zB-5ez7A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 LEU A 155
GLY A  44
GLY A 197
ILE A  70
LEU A  33
SO4  A 302 (-4.7A)
None
None
None
None
1.00A 5l0zB-5f8zA:
undetectable
5l0zB-5f8zA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Pseudomonas
aeruginosa)
PF00588
(SpoU_methylase)
8 THR A  79
GLY A 115
GLY A 120
ILE A 135
SER A 143
LEU A 144
LEU A 146
ALA A 149
None
0.65A 5l0zB-5gmbA:
7.2
5l0zB-5gmbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gra TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Zymomonas
mobilis)
PF00588
(SpoU_methylase)
5 THR A  81
GLY A 114
GLY A 119
LEU A 145
ALA A 148
None
0.62A 5l0zB-5graA:
6.7
5l0zB-5graA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gra TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Zymomonas
mobilis)
PF00588
(SpoU_methylase)
5 THR A  81
GLY A 114
LEU A 143
LEU A 145
ALA A 148
None
0.65A 5l0zB-5graA:
6.7
5l0zB-5graA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC


(Arabidopsis
thaliana)
PF02861
(Clp_N)
5 GLY A 132
GLY A 134
ILE A 106
SER A 198
LEU A 201
None
None
None
PO4  A 301 (-2.5A)
None
0.92A 5l0zB-5guiA:
undetectable
5l0zB-5guiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus)
no annotation 5 LEU A 155
GLY A  44
GLY A 197
ILE A  70
LEU A  33
None
0.99A 5l0zB-5gvtA:
undetectable
5l0zB-5gvtA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Sinorhizobium
meliloti)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
9 THR A 212
GLY A 235
GLY A 240
ILE A 255
GLN A 257
SER A 263
LEU A 264
LEU A 266
ALA A 269
SAM  A 304 (-3.7A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
0.47A 5l0zB-5l0zA:
39.2
5l0zB-5l0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Sinorhizobium
meliloti)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
8 THR A 212
LEU A 214
GLY A 235
GLY A 240
ILE A 255
GLN A 257
LEU A 266
ALA A 269
SAM  A 304 (-3.7A)
SAM  A 304 (-4.3A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
0.80A 5l0zB-5l0zA:
39.2
5l0zB-5l0zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l38 MSM0272 - RMM
MICROCOMPARTMENT
SHELL PROTEIN


(Mycolicibacterium
smegmatis)
PF00936
(BMC)
5 GLY A  13
GLY A  41
ILE A   9
LEU A  71
ALA A  65
None
1.02A 5l0zB-5l38A:
undetectable
5l0zB-5l38A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID


(Human
mastadenovirus
C)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 LEU A 573
GLY A 349
GLY A 933
ILE A 568
ALA A 356
None
1.01A 5l0zB-5ldnA:
undetectable
5l0zB-5ldnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
5 LEU B 647
GLY B 651
ILE B 712
LEU B 703
ALA B 684
None
1.05A 5l0zB-5ldrB:
undetectable
5l0zB-5ldrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER


(Proteus
mirabilis)
no annotation 5 GLY A 173
GLY A 177
ILE A 167
SER A 345
LEU A 348
None
None
None
NA  A 502 (-2.3A)
None
0.90A 5l0zB-5nvaA:
undetectable
5l0zB-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER


(Proteus
mirabilis)
no annotation 5 GLY A 174
GLY A 177
ILE A 167
SER A 345
LEU A 348
None
None
None
NA  A 502 (-2.3A)
None
0.99A 5l0zB-5nvaA:
undetectable
5l0zB-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 5 LEU A 356
GLY A 202
GLY A 204
ILE A 198
LEU A 158
None
None
None
GOL  A 606 (-4.5A)
None
0.94A 5l0zB-5oc1A:
undetectable
5l0zB-5oc1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF01041
(DegT_DnrJ_EryC1)
5 THR A  83
ILE A  85
LEU A  89
LEU A  62
ALA A  86
None
None
None
None
7SG  A 402 ( 3.7A)
1.03A 5l0zB-5u24A:
undetectable
5l0zB-5u24A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis)
PF02016
(Peptidase_S66)
5 THR A 207
LEU A 211
GLY A 203
GLY A 202
LEU A 116
None
0.79A 5l0zB-5usdA:
2.0
5l0zB-5usdA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)


(Mycobacterium
tuberculosis)
PF00975
(Thioesterase)
5 LEU A1657
GLY A1531
GLY A1536
ILE A1695
ALA A1702
None
1.01A 5l0zB-5v41A:
3.1
5l0zB-5v41A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR


(Actinomyces
oris)
no annotation 5 THR A 174
LEU A 189
GLY A 170
ILE A 132
ALA A 129
None
1.01A 5l0zB-5v8cA:
undetectable
5l0zB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
no annotation 5 THR A 312
GLY A 316
ILE A 292
SER A 283
LEU A 327
None
0.88A 5l0zB-5xb7A:
undetectable
5l0zB-5xb7A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris)
no annotation 5 GLY A 510
ILE A 428
LEU A 489
LEU A 491
ALA A 490
None
1.02A 5l0zB-5z0uA:
3.3
5l0zB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa)
no annotation 5 LEU A 160
GLY A 157
LEU A 204
LEU A 202
ALA A 205
None
1.02A 5l0zB-6amsA:
undetectable
5l0zB-6amsA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gt1 SERINE/THREONINE-PRO
TEIN KINASE NEK7


(Homo sapiens)
no annotation 5 GLY A 178
ILE A  40
LEU A 113
LEU A 111
ALA A  61
None
F9N  A 401 (-4.0A)
F9N  A 401 ( 4.9A)
F9N  A 401 ( 4.6A)
F9N  A 401 ( 4.2A)
0.96A 5l0zB-6gt1A:
undetectable
5l0zB-6gt1A:
undetectable