SIMILAR PATTERNS OF AMINO ACIDS FOR 5L0Z_A_SAMA304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)


(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
5 THR B 412
GLY B 409
GLY B 476
ILE B 442
LEU B 449
None
0.95A 5l0zA-1a6dB:
3.1
5l0zA-1a6dB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)


(Amycolatopsis
mediterranei)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 181
GLY A  62
GLY A 196
ILE A 179
ALA A  69
None
PLP  A 389 (-3.5A)
None
None
None
1.03A 5l0zA-1b9hA:
undetectable
5l0zA-1b9hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE


(Escherichia
coli)
PF00266
(Aminotran_5)
6 GLY A  74
GLY A  78
ILE A 207
ASP A 174
SER A 176
ALA A 196
None
None
None
LLP  A 198 ( 3.0A)
LLP  A 198 ( 3.9A)
None
1.39A 5l0zA-1bjnA:
undetectable
5l0zA-1bjnA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 GLY A 199
ILE A 216
SER A 224
LEU A 225
ALA A 230
None
0.66A 5l0zA-1gz0A:
23.7
5l0zA-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
6 THR A 174
GLY A 196
GLY A 201
ILE A 216
LEU A 225
ALA A 230
None
0.66A 5l0zA-1gz0A:
23.7
5l0zA-1gz0A:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
7 THR A 193
GLY A 215
GLY A 220
ILE A 235
ASP A 242
SER A 243
LEU A 244
None
1.20A 5l0zA-1ipaA:
23.6
5l0zA-1ipaA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae)
PF00588
(SpoU_methylase)
5 GLY A 100
GLY A 105
ILE A 122
SER A 130
LEU A 133
None
0.97A 5l0zA-1j85A:
18.9
5l0zA-1j85A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001


(Methanothermobacter
thermautotrophicus)
PF02598
(Methyltrn_RNA_3)
5 THR A 189
GLY A 218
GLY A 223
GLN A 239
ALA A 249
None
0.93A 5l0zA-1k3rA:
11.8
5l0zA-1k3rA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus)
PF00054
(Laminin_G_1)
5 THR A  23
GLY A  21
GLY A 162
ILE A  17
ALA A  18
None
1.02A 5l0zA-1q56A:
undetectable
5l0zA-1q56A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
6 GLY A 211
ILE A 160
ASP A 202
SER A 134
LEU A 181
ALA A 183
None
1.46A 5l0zA-1tonA:
undetectable
5l0zA-1tonA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
8 THR A  99
LEU A 101
GLY A 122
GLY A 127
ILE A 142
SER A 150
LEU A 151
ALA A 156
SAM  A 400 (-3.2A)
SAM  A 400 ( 4.1A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.8A)
SAM  A 400 (-3.6A)
SAM  A 400 ( 3.7A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.5A)
0.52A 5l0zA-1v2xA:
19.2
5l0zA-1v2xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR


(Homo sapiens)
PF13561
(adh_short_C2)
5 THR A  76
GLY A  67
GLN A 102
LEU A  96
ALA A 100
None
1.03A 5l0zA-1w8dA:
2.2
5l0zA-1w8dA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x7p RRNA
METHYLTRANSFERASE


(Streptomyces
viridochromogenes)
PF00588
(SpoU_methylase)
7 THR A 210
GLY A 232
GLY A 237
ILE A 252
SER A 260
LEU A 261
ALA A 266
SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
0.65A 5l0zA-1x7pA:
29.3
5l0zA-1x7pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
6 LEU A 105
GLY A 126
GLY A 131
SER A 154
LEU A 155
ALA A 160
GOL  A 530 ( 4.5A)
GOL  A 529 (-4.0A)
GOL  A 530 (-3.7A)
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.6A)
1.19A 5l0zA-1zjrA:
9.6
5l0zA-1zjrA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
7 THR A 103
LEU A 105
GLY A 126
ILE A 146
SER A 154
LEU A 155
ALA A 160
GOL  A 529 (-3.0A)
GOL  A 530 ( 4.5A)
GOL  A 529 (-4.0A)
None
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.6A)
0.87A 5l0zA-1zjrA:
9.6
5l0zA-1zjrA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE


(Klebsiella
aerogenes)
PF00144
(Beta-lactamase)
6 THR A 316
GLY A 318
GLY A 203
ILE A  63
LEU A 336
ALA A 321
ACY  A1402 (-4.3A)
None
None
None
None
None
1.39A 5l0zA-1zkjA:
undetectable
5l0zA-1zkjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 GLY A 196
GLY A 195
ARG A 245
LEU A 201
ALA A 240
None
0.92A 5l0zA-2a9fA:
3.3
5l0zA-2a9fA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 GLY A  55
GLY A  51
GLN A 143
SER A 144
LEU A 148
ALA A  60
None
FAD  A1524 ( 4.8A)
None
None
None
None
1.31A 5l0zA-2c3dA:
4.2
5l0zA-2c3dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Thermus
thermophilus)
PF00106
(adh_short)
5 GLY A 136
ILE A 117
LEU A 160
LEU A 158
ALA A 161
None
0.99A 5l0zA-2ehdA:
3.4
5l0zA-2ehdA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN


(Homo sapiens)
PF00588
(SpoU_methylase)
6 GLY A 129
GLY A 134
ILE A 149
GLN A 151
SER A 157
LEU A 158
SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
0.31A 5l0zA-2ha8A:
20.9
5l0zA-2ha8A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Porphyromonas
gingivalis)
PF00588
(SpoU_methylase)
7 LEU A 181
GLY A 203
GLY A 208
ILE A 223
SER A 236
LEU A 237
ALA A 242
None
0.82A 5l0zA-2i6dA:
26.0
5l0zA-2i6dA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae)
PF05860
(Haemagg_act)
5 GLY A 387
GLY A 383
ILE A 403
ASP A 342
ALA A 390
None
0.88A 5l0zA-2odlA:
undetectable
5l0zA-2odlA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 THR A  92
ILE A  94
LEU A  98
LEU A  71
ALA A  95
None
None
None
None
PGU  A1020 (-3.5A)
1.04A 5l0zA-2ogaA:
undetectable
5l0zA-2ogaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae)
PF01872
(RibD_C)
5 THR A 112
GLY A  78
ILE A 166
LEU A 175
ALA A 178
None
EDO  A 282 ( 3.4A)
None
None
None
0.97A 5l0zA-2p4gA:
undetectable
5l0zA-2p4gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II


(Caldanaerobacter
subterraneus)
PF00753
(Lactamase_B)
5 THR A 257
GLY A 224
ARG A 229
ILE A 259
LEU A 276
None
0.96A 5l0zA-2p4zA:
undetectable
5l0zA-2p4zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens)
PF00144
(Beta-lactamase)
6 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
None
1.41A 5l0zA-2qz6A:
undetectable
5l0zA-2qz6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A 305
GLY A 336
GLY A 311
ILE A  15
LEU A 246
None
1.00A 5l0zA-2r3vA:
undetectable
5l0zA-2r3vA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus)
PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4)
5 GLY A 167
ILE A 134
GLN A 106
LEU A  76
ALA A 173
GOL  A1251 (-3.6A)
None
None
None
None
1.02A 5l0zA-2wtnA:
4.1
5l0zA-2wtnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum)
PF02811
(PHP)
5 GLY A  62
ILE A  23
SER A  10
LEU A  45
ALA A  48
None
1.01A 5l0zA-2yb4A:
undetectable
5l0zA-2yb4A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Thermotoga
maritima)
PF02222
(ATP-grasp)
5 GLY A  39
ILE A   4
ASP A  69
LEU A  18
ALA A  20
None
0.98A 5l0zA-3ax6A:
2.3
5l0zA-3ax6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron)
PF13472
(Lipase_GDSL_2)
5 LEU A 184
GLY A 229
GLY A 225
ILE A 111
LEU A 173
None
0.97A 5l0zA-3bzwA:
undetectable
5l0zA-3bzwA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli)
PF10672
(Methyltrans_SAM)
5 LEU A 324
GLY A 317
ILE A 326
GLN A 327
ALA A 356
None
0.97A 5l0zA-3c0kA:
2.3
5l0zA-3c0kA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570


(Thermotoga
maritima)
PF09936
(Methyltrn_RNA_4)
6 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
0.47A 5l0zA-3dcmX:
13.8
5l0zA-3dcmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5y TRMH FAMILY RNA
METHYLTRANSFERASE


(Burkholderia
pseudomallei)
PF00588
(SpoU_methylase)
5 GLY A 102
GLY A 107
SER A 132
LEU A 133
LEU A 135
None
0.79A 5l0zA-3e5yA:
17.9
5l0zA-3e5yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 THR A1068
GLY A1073
ASP A1144
SER A1145
LEU A1146
None
0.92A 5l0zA-3fawA:
undetectable
5l0zA-3fawA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1


(Nitrosomonas
europaea)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 GLY A 259
GLY A 141
ILE A 174
ASP A 181
ALA A 255
None
0.78A 5l0zA-3g5wA:
undetectable
5l0zA-3g5wA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE


(Streptomyces
cyaneus)
PF00588
(SpoU_methylase)
PF04705
(TSNR_N)
5 GLY A 218
GLY A 223
ILE A 238
SER A 246
LEU A 247
SAM  A 270 (-2.9A)
None
SAM  A 270 (-3.5A)
SAM  A 270 (-2.8A)
SAM  A 270 (-4.4A)
0.85A 5l0zA-3gyqA:
22.9
5l0zA-3gyqA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN


(Neisseria
gonorrhoeae)
PF00588
(SpoU_methylase)
6 GLY A 145
GLY A 150
ILE A 165
LEU A 174
LEU A 176
ALA A 179
None
0.60A 5l0zA-3ic6A:
15.4
5l0zA-3ic6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilk UNCHARACTERIZED
TRNA/RRNA
METHYLTRANSFERASE
HI0380


(Haemophilus
influenzae)
PF00588
(SpoU_methylase)
8 THR A  78
GLY A 111
GLY A 116
ILE A 131
SER A 139
LEU A 140
LEU A 142
ALA A 145
EDO  A 242 (-3.4A)
EDO  A 242 (-4.6A)
None
EDO  A 243 (-4.0A)
None
None
EDO  A 242 ( 4.5A)
EDO  A 242 ( 3.7A)
0.71A 5l0zA-3ilkA:
17.1
5l0zA-3ilkA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Thermotoga
maritima)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 285
GLY A 220
GLY A 219
ILE A 230
ALA A 226
None
0.98A 5l0zA-3ip1A:
2.2
5l0zA-3ip1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1


(Deltapapillomavirus
4)
no annotation 5 THR F 114
GLY F 144
ILE F 220
GLN F 221
LEU F 216
None
0.95A 5l0zA-3iyjF:
undetectable
5l0zA-3iyjF:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN


(Rhodobacter
sphaeroides)
PF02126
(PTE)
5 GLY A 177
ARG A 107
ILE A 155
LEU A 190
ALA A 193
None
0.95A 5l0zA-3k2gA:
2.8
5l0zA-3k2gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE


(Bordetella
pertussis)
PF00588
(SpoU_methylase)
5 GLY A 123
GLY A 128
ILE A 143
LEU A 152
ALA A 157
None
0.77A 5l0zA-3ktyA:
18.7
5l0zA-3ktyA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE


(Streptococcus
mutans)
PF00588
(SpoU_methylase)
6 GLY A 117
GLY A 122
ILE A 138
SER A 147
LEU A 148
LEU A 150
None
0.69A 5l0zA-3l8uA:
18.6
5l0zA-3l8uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE


(Yersinia pestis)
PF00588
(SpoU_methylase)
7 GLY A 105
GLY A 110
ARG A 126
ILE A 127
SER A 135
LEU A 138
ALA A 141
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
None
SAH  A 201 (-3.8A)
SAH  A 201 (-3.3A)
SAH  A 201 (-4.3A)
SAH  A 201 ( 4.0A)
0.57A 5l0zA-3n4kA:
17.5
5l0zA-3n4kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE


(Streptomyces
actuosus)
PF00588
(SpoU_methylase)
PF04705
(TSNR_N)
5 GLY A 218
GLY A 223
ILE A 238
SER A 246
LEU A 247
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
0.57A 5l0zA-3nk7A:
23.9
5l0zA-3nk7A:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE


(Salmonella
enterica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 296
GLY A 317
ILE A 298
SER A  38
LEU A  39
None
1.04A 5l0zA-3nx4A:
undetectable
5l0zA-3nx4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY


(Bacteroides
ovatus)
PF09992
(NAGPA)
5 GLY A 271
GLY A 272
ILE A  78
GLN A  76
LEU A 249
None
SO4  A 402 (-3.6A)
None
None
None
0.94A 5l0zA-3ohgA:
undetectable
5l0zA-3ohgA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)


(Rhodobacter
sphaeroides)
PF00588
(SpoU_methylase)
5 THR A  80
GLY A 116
GLY A 121
LEU A 145
LEU A 147
BME  A 251 ( 4.4A)
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
ACY  A 250 ( 4.5A)
0.70A 5l0zA-3onpA:
17.0
5l0zA-3onpA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE


(Rhodospirillum
rubrum)
PF01261
(AP_endonuc_2)
5 THR A  70
GLY A 113
SER A  76
LEU A  97
ALA A 100
None
0.91A 5l0zA-3qxbA:
2.9
5l0zA-3qxbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2


(Magnaporthe
oryzae)
PF00141
(peroxidase)
5 GLY A 155
GLY A 156
SER A 193
LEU A 197
LEU A 199
None
1.04A 5l0zA-3ut2A:
undetectable
5l0zA-3ut2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE


(Pyrococcus
horikoshii)
PF00150
(Cellulase)
6 GLY A 253
GLY A 274
ILE A 249
ASP A 153
LEU A 198
ALA A 233
None
1.28A 5l0zA-3w6mA:
undetectable
5l0zA-3w6mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09754
(PAC2)
5 GLY A  27
GLY A 180
ILE A 153
LEU A 175
ALA A 114
None
0.94A 5l0zA-3wz2A:
2.1
5l0zA-3wz2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
5 THR A 426
GLY A 253
ILE A 549
ASP A 228
LEU A 318
1PE  A1553 (-3.7A)
None
1PE  A1553 ( 3.7A)
None
None
0.93A 5l0zA-4be9A:
undetectable
5l0zA-4be9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
5 GLY A 397
GLY A 399
LEU A 729
LEU A 731
ALA A 728
None
1.01A 5l0zA-4bevA:
4.1
5l0zA-4bevA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius)
PF00588
(SpoU_methylase)
7 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
LEU A 142
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 4.4A)
SAH  A1157 ( 3.7A)
0.29A 5l0zA-4cngA:
19.1
5l0zA-4cngA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv6 TRANSCRIPTIONAL
REGULATOR MNTR


(Bacillus
subtilis)
PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
5 GLY A  66
ILE A  28
GLN A  12
LEU A  16
ALA A  23
None
1.03A 5l0zA-4hv6A:
undetectable
5l0zA-4hv6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Escherichia
coli)
PF00588
(SpoU_methylase)
5 GLY A 100
GLY A 105
ILE A 122
LEU A 133
ALA A 136
None
0.50A 5l0zA-4kdzA:
19.1
5l0zA-4kdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Escherichia
coli)
PF00588
(SpoU_methylase)
5 GLY A 100
GLY A 105
ILE A 122
SER A 130
LEU A 133
None
0.93A 5l0zA-4kdzA:
19.1
5l0zA-4kdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum)
PF00578
(AhpC-TSA)
5 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
None
1.02A 5l0zA-4kw6A:
3.2
5l0zA-4kw6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE


(Serratia
plymuthica)
PF00465
(Fe-ADH)
5 THR A 120
GLY A 272
GLY A 170
ILE A 117
LEU A 164
None
1.02A 5l0zA-4mcaA:
undetectable
5l0zA-4mcaA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE


(Thermotoga
maritima)
PF09861
(DUF2088)
6 GLY A 302
ARG A 266
ILE A 264
ASP A 406
SER A 409
LEU A 410
None
1.10A 5l0zA-4narA:
undetectable
5l0zA-4narA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN


(Synechococcus
sp.
JA-2-3B'a(2-13))
PF07884
(VKOR)
5 LEU A 143
GLY A  28
GLY A  30
LEU A  84
ALA A  87
None
0.89A 5l0zA-4nv2A:
undetectable
5l0zA-4nv2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozs ALPHA SOLENOID
PROTEIN


(synthetic
construct)
PF12854
(PPR_1)
PF13041
(PPR_2)
5 THR A  42
GLY A  46
LEU A  12
LEU A  18
ALA A  21
None
1.04A 5l0zA-4ozsA:
undetectable
5l0zA-4ozsA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozs ALPHA SOLENOID
PROTEIN


(synthetic
construct)
PF12854
(PPR_1)
PF13041
(PPR_2)
5 THR A 112
GLY A 116
LEU A  82
LEU A  88
ALA A  91
None
1.04A 5l0zA-4ozsA:
undetectable
5l0zA-4ozsA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
6 GLY C 337
GLY C 340
ILE C 354
GLN C 353
SER C 284
ALA C 355
None
1.27A 5l0zA-4pd4C:
undetectable
5l0zA-4pd4C:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pjs PENTATRICOPEPTIDE
REPEAT PROTEIN


(unidentified)
PF13041
(PPR_2)
5 THR A 218
GLY A 222
LEU A 188
LEU A 194
ALA A 197
None
1.04A 5l0zA-4pjsA:
undetectable
5l0zA-4pjsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pjs PENTATRICOPEPTIDE
REPEAT PROTEIN


(unidentified)
PF13041
(PPR_2)
5 THR A 253
GLY A 257
LEU A 223
LEU A 229
ALA A 232
None
1.02A 5l0zA-4pjsA:
undetectable
5l0zA-4pjsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Bacillus
anthracis)
PF00588
(SpoU_methylase)
7 GLY A 104
GLY A 109
ARG A 124
ILE A 125
SER A 133
LEU A 134
LEU A 136
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
None
SAH  A 201 (-3.9A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
SAH  A 201 ( 4.3A)
0.59A 5l0zA-4pzkA:
18.9
5l0zA-4pzkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
5 THR A 519
GLY A 521
ILE A 511
GLN A 510
LEU A 466
GOL  A 902 (-4.5A)
None
GOL  A 902 ( 4.7A)
None
GOL  A 902 ( 4.6A)
0.97A 5l0zA-4q6rA:
undetectable
5l0zA-4q6rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens)
PF02598
(Methyltrn_RNA_3)
5 THR A 289
GLY A 312
GLY A 316
GLN A 346
ALA A 356
SAH  A 401 (-3.8A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.4A)
0.63A 5l0zA-4rg1A:
11.7
5l0zA-4rg1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF00144
(Beta-lactamase)
6 THR A 346
GLY A 348
GLY A 229
ILE A  88
LEU A 366
ALA A 351
None
1.41A 5l0zA-4x68A:
undetectable
5l0zA-4x68A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
7 THR A  79
GLY A 114
GLY A 119
ILE A 134
LEU A 143
LEU A 145
ALA A 148
SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.6A)
0.40A 5l0zA-4xboA:
17.4
5l0zA-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
7 THR A  79
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
ALA A 148
SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
0.79A 5l0zA-4xboA:
17.4
5l0zA-4xboA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
6 LEU A 124
GLY A 149
GLY A 153
ILE A 174
LEU A 179
ALA A 177
None
None
SEB  A 151 ( 4.0A)
None
None
None
1.40A 5l0zA-4zrsA:
3.0
5l0zA-4zrsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1)
5 LEU A 527
GLY A 590
GLY A 525
LEU A 491
ALA A 604
None
1.02A 5l0zA-5a42A:
undetectable
5l0zA-5a42A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii)
PF00118
(Cpn60_TCP1)
5 GLY A 376
GLY A 193
ARG A 369
ILE A 370
ASP A 342
None
1.02A 5l0zA-5cdiA:
undetectable
5l0zA-5cdiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 7 GLY B 101
GLY B 106
ILE B 120
SER B 128
LEU B 129
LEU B 131
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 ( 4.2A)
MTA  B 401 (-3.5A)
0.47A 5l0zA-5co4B:
20.0
5l0zA-5co4B:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis)
PF00144
(Beta-lactamase)
6 THR A 311
GLY A 313
GLY A 196
ILE A  56
LEU A 331
ALA A 316
None
1.43A 5l0zA-5e2hA:
undetectable
5l0zA-5e2hA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Pseudomonas
aeruginosa)
PF00588
(SpoU_methylase)
6 GLY A 115
ILE A 135
SER A 143
LEU A 144
LEU A 146
ALA A 149
None
0.65A 5l0zA-5gmbA:
18.1
5l0zA-5gmbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Pseudomonas
aeruginosa)
PF00588
(SpoU_methylase)
7 THR A  79
GLY A 115
GLY A 120
ILE A 135
LEU A 144
LEU A 146
ALA A 149
None
0.52A 5l0zA-5gmbA:
18.1
5l0zA-5gmbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gra TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Zymomonas
mobilis)
PF00588
(SpoU_methylase)
5 THR A  81
GLY A 114
GLY A 119
LEU A 145
ALA A 148
None
0.62A 5l0zA-5graA:
17.7
5l0zA-5graA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gra TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Zymomonas
mobilis)
PF00588
(SpoU_methylase)
5 THR A  81
GLY A 114
LEU A 143
LEU A 145
ALA A 148
None
0.58A 5l0zA-5graA:
17.7
5l0zA-5graA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC


(Arabidopsis
thaliana)
PF02861
(Clp_N)
5 GLY A 132
GLY A 134
ILE A 106
SER A 198
LEU A 201
None
None
None
PO4  A 301 (-2.5A)
None
1.02A 5l0zA-5guiA:
undetectable
5l0zA-5guiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2


(unidentified)
PF12854
(PPR_1)
PF13041
(PPR_2)
5 THR C  91
GLY C  95
LEU C  61
LEU C  67
ALA C  70
U  A  -3 ( 4.1A)
None
None
None
None
1.02A 5l0zA-5i9gC:
undetectable
5l0zA-5i9gC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2


(unidentified)
PF12854
(PPR_1)
PF13041
(PPR_2)
5 THR C 126
GLY C 130
LEU C  96
LEU C 102
ALA C 105
U  A  -2 ( 3.9A)
None
None
None
None
0.99A 5l0zA-5i9gC:
undetectable
5l0zA-5i9gC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2


(unidentified)
PF12854
(PPR_1)
PF13041
(PPR_2)
5 THR C 266
GLY C 270
LEU C 236
LEU C 242
ALA C 245
U  A   2 ( 3.9A)
None
None
None
None
1.00A 5l0zA-5i9gC:
undetectable
5l0zA-5i9gC:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY


(Sinorhizobium
meliloti)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
12 THR A 212
LEU A 214
GLY A 235
GLY A 240
ARG A 254
ILE A 255
GLN A 257
ASP A 262
SER A 263
LEU A 264
LEU A 266
ALA A 269
SAM  A 304 (-3.7A)
SAM  A 304 (-4.3A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
None
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SAM  A 304 (-3.0A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
0.00A 5l0zA-5l0zA:
44.4
5l0zA-5l0zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l38 MSM0272 - RMM
MICROCOMPARTMENT
SHELL PROTEIN


(Mycolicibacterium
smegmatis)
PF00936
(BMC)
5 GLY A  13
GLY A  41
ILE A   9
LEU A  71
ALA A  65
None
1.01A 5l0zA-5l38A:
undetectable
5l0zA-5l38A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnc VACUOLAR TRANSPORTER
CHAPERONE 4,CORE
HISTONE MACRO-H2A.1


(Saccharomyces
cerevisiae;
Homo sapiens)
PF01661
(Macro)
PF03105
(SPX)
5 GLY A 313
GLY A 315
ASP A 353
SER A 356
ALA A 325
None
1.03A 5l0zA-5lncA:
undetectable
5l0zA-5lncA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni)
PF00873
(ACR_tran)
5 GLY A 931
ILE A 882
GLN A 886
LEU A 450
LEU A 452
None
0.99A 5l0zA-5lq3A:
undetectable
5l0zA-5lq3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III


(Methanococcoides
burtonii)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 GLY A 426
ILE A 454
LEU A 464
LEU A 441
ALA A 444
None
1.04A 5l0zA-5macA:
3.3
5l0zA-5macA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5orm CPPR-TELO1

(synthetic
construct)
no annotation 5 THR A 290
GLY A 294
LEU A 260
LEU A 266
ALA A 269
None
1.04A 5l0zA-5ormA:
undetectable
5l0zA-5ormA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF01041
(DegT_DnrJ_EryC1)
5 THR A  83
ILE A  85
LEU A  89
LEU A  62
ALA A  86
None
None
None
None
7SG  A 402 ( 3.7A)
0.98A 5l0zA-5u24A:
undetectable
5l0zA-5u24A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrq ANKYRIN
REPEAT-CONTAINING
PROTEIN


(Legionella
pneumophila)
no annotation 5 LEU A 160
GLY A  96
ASP A 151
LEU A  89
ALA A 101
None
0.98A 5l0zA-5vrqA:
undetectable
5l0zA-5vrqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
no annotation 5 THR A 312
GLY A 316
ILE A 292
SER A 283
LEU A 327
None
0.76A 5l0zA-5xb7A:
undetectable
5l0zA-5xb7A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor)
no annotation 5 GLY A  77
ILE A 314
ASP A 155
LEU A 157
ALA A 162
None
0.95A 5l0zA-5z0cA:
2.7
5l0zA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli)
no annotation 6 THR A 318
GLY A 320
GLY A 202
ILE A  62
LEU A 338
ALA A 323
EPE  A 405 (-4.1A)
None
None
None
None
None
1.39A 5l0zA-5za2A:
undetectable
5l0zA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 LEU A 311
GLY A 308
ILE A 299
LEU A 330
ALA A 303
None
0.97A 5l0zA-6bogA:
undetectable
5l0zA-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes)
no annotation 6 THR A 316
GLY A 318
GLY A 200
ILE A  60
LEU A 336
ALA A 321
None
SO4  A 403 (-3.5A)
None
None
None
None
1.32A 5l0zA-6fm7A:
undetectable
5l0zA-6fm7A:
undetectable