SIMILAR PATTERNS OF AMINO ACIDS FOR 5L0Z_A_SAMA304
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6d | THERMOSOME (BETASUBUNIT) (Thermoplasmaacidophilum) |
PF00118(Cpn60_TCP1) | 5 | THR B 412GLY B 409GLY B 476ILE B 442LEU B 449 | None | 0.95A | 5l0zA-1a6dB:3.1 | 5l0zA-1a6dB:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9h | PROTEIN(3-AMINO-5-HYDROXYBENZOIC ACID SYNTHASE) (Amycolatopsismediterranei) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 181GLY A 62GLY A 196ILE A 179ALA A 69 | NonePLP A 389 (-3.5A)NoneNoneNone | 1.03A | 5l0zA-1b9hA:undetectable | 5l0zA-1b9hA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bjn | PHOSPHOSERINEAMINOTRANSFERASE (Escherichiacoli) |
PF00266(Aminotran_5) | 6 | GLY A 74GLY A 78ILE A 207ASP A 174SER A 176ALA A 196 | NoneNoneNoneLLP A 198 ( 3.0A)LLP A 198 ( 3.9A)None | 1.39A | 5l0zA-1bjnA:undetectable | 5l0zA-1bjnA:25.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | GLY A 199ILE A 216SER A 224LEU A 225ALA A 230 | None | 0.66A | 5l0zA-1gz0A:23.7 | 5l0zA-1gz0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 6 | THR A 174GLY A 196GLY A 201ILE A 216LEU A 225ALA A 230 | None | 0.66A | 5l0zA-1gz0A:23.7 | 5l0zA-1gz0A:28.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ipa | RNA 2'-O-RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 7 | THR A 193GLY A 215GLY A 220ILE A 235ASP A 242SER A 243LEU A 244 | None | 1.20A | 5l0zA-1ipaA:23.6 | 5l0zA-1ipaA:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j85 | YIBK (Haemophilusinfluenzae) |
PF00588(SpoU_methylase) | 5 | GLY A 100GLY A 105ILE A 122SER A 130LEU A 133 | None | 0.97A | 5l0zA-1j85A:18.9 | 5l0zA-1j85A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3r | CONSERVED PROTEINMT0001 (Methanothermobacterthermautotrophicus) |
PF02598(Methyltrn_RNA_3) | 5 | THR A 189GLY A 218GLY A 223GLN A 239ALA A 249 | None | 0.93A | 5l0zA-1k3rA:11.8 | 5l0zA-1k3rA:26.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q56 | AGRIN (Gallus gallus) |
PF00054(Laminin_G_1) | 5 | THR A 23GLY A 21GLY A 162ILE A 17ALA A 18 | None | 1.02A | 5l0zA-1q56A:undetectable | 5l0zA-1q56A:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ton | TONIN (Rattus rattus) |
PF00089(Trypsin) | 6 | GLY A 211ILE A 160ASP A 202SER A 134LEU A 181ALA A 183 | None | 1.46A | 5l0zA-1tonA:undetectable | 5l0zA-1tonA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2x | TRNA (GM18)METHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 8 | THR A 99LEU A 101GLY A 122GLY A 127ILE A 142SER A 150LEU A 151ALA A 156 | SAM A 400 (-3.2A)SAM A 400 ( 4.1A)SAM A 400 (-3.2A)SAM A 400 (-3.8A)SAM A 400 (-3.6A)SAM A 400 ( 3.7A)SAM A 400 (-4.0A)SAM A 400 (-3.5A) | 0.52A | 5l0zA-1v2xA:19.2 | 5l0zA-1v2xA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8d | 2,4-DIENOYL-COAREDUCTASE,MITOCHONDRIALPRECURSOR (Homo sapiens) |
PF13561(adh_short_C2) | 5 | THR A 76GLY A 67GLN A 102LEU A 96ALA A 100 | None | 1.03A | 5l0zA-1w8dA:2.2 | 5l0zA-1w8dA:21.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x7p | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF00588(SpoU_methylase) | 7 | THR A 210GLY A 232GLY A 237ILE A 252SER A 260LEU A 261ALA A 266 | SAM A 301 (-3.6A)SAM A 301 (-3.2A)SAM A 301 (-3.4A)SAM A 301 (-4.0A)SAM A 301 ( 3.7A)SAM A 301 (-4.1A)SAM A 301 (-3.4A) | 0.65A | 5l0zA-1x7pA:29.3 | 5l0zA-1x7pA:32.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 6 | LEU A 105GLY A 126GLY A 131SER A 154LEU A 155ALA A 160 | GOL A 530 ( 4.5A)GOL A 529 (-4.0A)GOL A 530 (-3.7A)GOL A 529 (-3.5A)NoneGOL A 529 (-3.6A) | 1.19A | 5l0zA-1zjrA:9.6 | 5l0zA-1zjrA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 7 | THR A 103LEU A 105GLY A 126ILE A 146SER A 154LEU A 155ALA A 160 | GOL A 529 (-3.0A)GOL A 530 ( 4.5A)GOL A 529 (-4.0A)NoneGOL A 529 (-3.5A)NoneGOL A 529 (-3.6A) | 0.87A | 5l0zA-1zjrA:9.6 | 5l0zA-1zjrA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkj | EXTENDED-SPECTRUMBETA-LACTAMASE (Klebsiellaaerogenes) |
PF00144(Beta-lactamase) | 6 | THR A 316GLY A 318GLY A 203ILE A 63LEU A 336ALA A 321 | ACY A1402 (-4.3A)NoneNoneNoneNoneNone | 1.39A | 5l0zA-1zkjA:undetectable | 5l0zA-1zkjA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9f | PUTATIVE MALICENZYME((S)-MALATE:NAD+OXIDOREDUCTASE(DECARBOXYLATING)) (Streptococcuspyogenes) |
PF00390(malic)PF03949(Malic_M) | 5 | GLY A 196GLY A 195ARG A 245LEU A 201ALA A 240 | None | 0.92A | 5l0zA-2a9fA:3.3 | 5l0zA-2a9fA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3d | 2-OXOPROPYL-COMREDUCTASE (Xanthobacterautotrophicus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | GLY A 55GLY A 51GLN A 143SER A 144LEU A 148ALA A 60 | NoneFAD A1524 ( 4.8A)NoneNoneNoneNone | 1.31A | 5l0zA-2c3dA:4.2 | 5l0zA-2c3dA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehd | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Thermusthermophilus) |
PF00106(adh_short) | 5 | GLY A 136ILE A 117LEU A 160LEU A 158ALA A 161 | None | 0.99A | 5l0zA-2ehdA:3.4 | 5l0zA-2ehdA:26.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ha8 | TAR (HIV-1) RNA LOOPBINDING PROTEIN (Homo sapiens) |
PF00588(SpoU_methylase) | 6 | GLY A 129GLY A 134ILE A 149GLN A 151SER A 157LEU A 158 | SAH A 401 (-3.1A)SAH A 401 (-3.2A)SAH A 401 (-3.8A)SAH A 401 (-3.7A)SAH A 401 ( 3.8A)SAH A 401 (-4.3A) | 0.31A | 5l0zA-2ha8A:20.9 | 5l0zA-2ha8A:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6d | RNAMETHYLTRANSFERASE,TRMH FAMILY (Porphyromonasgingivalis) |
PF00588(SpoU_methylase) | 7 | LEU A 181GLY A 203GLY A 208ILE A 223SER A 236LEU A 237ALA A 242 | None | 0.82A | 5l0zA-2i6dA:26.0 | 5l0zA-2i6dA:31.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odl | ADHESIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | GLY A 387GLY A 383ILE A 403ASP A 342ALA A 390 | None | 0.88A | 5l0zA-2odlA:undetectable | 5l0zA-2odlA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oga | TRANSAMINASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 92ILE A 94LEU A 98LEU A 71ALA A 95 | NoneNoneNoneNonePGU A1020 (-3.5A) | 1.04A | 5l0zA-2ogaA:undetectable | 5l0zA-2ogaA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 5 | THR A 112GLY A 78ILE A 166LEU A 175ALA A 178 | NoneEDO A 282 ( 3.4A)NoneNoneNone | 0.97A | 5l0zA-2p4gA:undetectable | 5l0zA-2p4gA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4z | METAL-DEPENDENTHYDROLASES OF THEBETA-LACTAMASESUPERFAMILY II (Caldanaerobactersubterraneus) |
PF00753(Lactamase_B) | 5 | THR A 257GLY A 224ARG A 229ILE A 259LEU A 276 | None | 0.96A | 5l0zA-2p4zA:undetectable | 5l0zA-2p4zA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qz6 | BETA-LACTAMASE (Pseudomonasfluorescens) |
PF00144(Beta-lactamase) | 6 | THR A 319GLY A 321GLY A 202ILE A 62LEU A 339ALA A 324 | None | 1.41A | 5l0zA-2qz6A:undetectable | 5l0zA-2qz6A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3v | MEVALONATE KINASE (Homo sapiens) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | LEU A 305GLY A 336GLY A 311ILE A 15LEU A 246 | None | 1.00A | 5l0zA-2r3vA:undetectable | 5l0zA-2r3vA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtn | EST1E (Butyrivibrioproteoclasticus) |
PF08386(Abhydrolase_4)PF12146(Hydrolase_4) | 5 | GLY A 167ILE A 134GLN A 106LEU A 76ALA A 173 | GOL A1251 (-3.6A)NoneNoneNoneNone | 1.02A | 5l0zA-2wtnA:4.1 | 5l0zA-2wtnA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yb4 | AMIDOHYDROLASE (Chromobacteriumviolaceum) |
PF02811(PHP) | 5 | GLY A 62ILE A 23SER A 10LEU A 45ALA A 48 | None | 1.01A | 5l0zA-2yb4A:undetectable | 5l0zA-2yb4A:24.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ax6 | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Thermotogamaritima) |
PF02222(ATP-grasp) | 5 | GLY A 39ILE A 4ASP A 69LEU A 18ALA A 20 | None | 0.98A | 5l0zA-3ax6A:2.3 | 5l0zA-3ax6A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bzw | PUTATIVE LIPASE (Bacteroidesthetaiotaomicron) |
PF13472(Lipase_GDSL_2) | 5 | LEU A 184GLY A 229GLY A 225ILE A 111LEU A 173 | None | 0.97A | 5l0zA-3bzwA:undetectable | 5l0zA-3bzwA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0k | UPF0064 PROTEIN YCCW (Escherichiacoli) |
PF10672(Methyltrans_SAM) | 5 | LEU A 324GLY A 317ILE A 326GLN A 327ALA A 356 | None | 0.97A | 5l0zA-3c0kA:2.3 | 5l0zA-3c0kA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcm | UNCHARACTERIZEDPROTEIN TM_1570 (Thermotogamaritima) |
PF09936(Methyltrn_RNA_4) | 6 | THR X 111GLY X 141GLY X 145ILE X 161LEU X 170ALA X 175 | SAM X5452 (-3.9A)SAM X5452 (-3.1A)SAM X5452 (-3.7A)SAM X5452 (-3.7A)SAM X5452 (-4.2A)SAM X5452 (-3.3A) | 0.47A | 5l0zA-3dcmX:13.8 | 5l0zA-3dcmX:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e5y | TRMH FAMILY RNAMETHYLTRANSFERASE (Burkholderiapseudomallei) |
PF00588(SpoU_methylase) | 5 | GLY A 102GLY A 107SER A 132LEU A 133LEU A 135 | None | 0.79A | 5l0zA-3e5yA:17.9 | 5l0zA-3e5yA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3faw | RETICULOCYTE BINDINGPROTEIN (Streptococcusagalactiae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | THR A1068GLY A1073ASP A1144SER A1145LEU A1146 | None | 0.92A | 5l0zA-3fawA:undetectable | 5l0zA-3fawA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5w | MULTICOPPER OXIDASETYPE 1 (Nitrosomonaseuropaea) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLY A 259GLY A 141ILE A 174ASP A 181ALA A 255 | None | 0.78A | 5l0zA-3g5wA:undetectable | 5l0zA-3g5wA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyq | RRNA(ADENOSINE-2'-O-)-METHYLTRANSFERASE (Streptomycescyaneus) |
PF00588(SpoU_methylase)PF04705(TSNR_N) | 5 | GLY A 218GLY A 223ILE A 238SER A 246LEU A 247 | SAM A 270 (-2.9A)NoneSAM A 270 (-3.5A)SAM A 270 (-2.8A)SAM A 270 (-4.4A) | 0.85A | 5l0zA-3gyqA:22.9 | 5l0zA-3gyqA:27.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic6 | PUTATIVE METHYLASEFAMILY PROTEIN (Neisseriagonorrhoeae) |
PF00588(SpoU_methylase) | 6 | GLY A 145GLY A 150ILE A 165LEU A 174LEU A 176ALA A 179 | None | 0.60A | 5l0zA-3ic6A:15.4 | 5l0zA-3ic6A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilk | UNCHARACTERIZEDTRNA/RRNAMETHYLTRANSFERASEHI0380 (Haemophilusinfluenzae) |
PF00588(SpoU_methylase) | 8 | THR A 78GLY A 111GLY A 116ILE A 131SER A 139LEU A 140LEU A 142ALA A 145 | EDO A 242 (-3.4A)EDO A 242 (-4.6A)NoneEDO A 243 (-4.0A)NoneNoneEDO A 242 ( 4.5A)EDO A 242 ( 3.7A) | 0.71A | 5l0zA-3ilkA:17.1 | 5l0zA-3ilkA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip1 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 285GLY A 220GLY A 219ILE A 230ALA A 226 | None | 0.98A | 5l0zA-3ip1A:2.2 | 5l0zA-3ip1A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyj | MAJOR CAPSID PROTEINL1 (Deltapapillomavirus4) |
no annotation | 5 | THR F 114GLY F 144ILE F 220GLN F 221LEU F 216 | None | 0.95A | 5l0zA-3iyjF:undetectable | 5l0zA-3iyjF:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2g | RESINIFERATOXIN-BINDING,PHOSPHOTRIESTERASE-RELATED PROTEIN (Rhodobactersphaeroides) |
PF02126(PTE) | 5 | GLY A 177ARG A 107ILE A 155LEU A 190ALA A 193 | None | 0.95A | 5l0zA-3k2gA:2.8 | 5l0zA-3k2gA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kty | PROBABLEMETHYLTRANSFERASE (Bordetellapertussis) |
PF00588(SpoU_methylase) | 5 | GLY A 123GLY A 128ILE A 143LEU A 152ALA A 157 | None | 0.77A | 5l0zA-3ktyA:18.7 | 5l0zA-3ktyA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8u | PUTATIVE RRNAMETHYLASE (Streptococcusmutans) |
PF00588(SpoU_methylase) | 6 | GLY A 117GLY A 122ILE A 138SER A 147LEU A 148LEU A 150 | None | 0.69A | 5l0zA-3l8uA:18.6 | 5l0zA-3l8uA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n4k | RNAMETHYLTRANSFERASE (Yersinia pestis) |
PF00588(SpoU_methylase) | 7 | GLY A 105GLY A 110ARG A 126ILE A 127SER A 135LEU A 138ALA A 141 | SAH A 201 (-3.1A)SAH A 201 (-3.4A)NoneSAH A 201 (-3.8A)SAH A 201 (-3.3A)SAH A 201 (-4.3A)SAH A 201 ( 4.0A) | 0.57A | 5l0zA-3n4kA:17.5 | 5l0zA-3n4kA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nk7 | 23S RRNAMETHYLTRANSFERASE (Streptomycesactuosus) |
PF00588(SpoU_methylase)PF04705(TSNR_N) | 5 | GLY A 218GLY A 223ILE A 238SER A 246LEU A 247 | SAM A 770 (-3.0A)SAM A 770 (-3.4A)SAM A 770 (-3.8A)SAM A 770 (-3.9A)SAM A 770 (-4.5A) | 0.57A | 5l0zA-3nk7A:23.9 | 5l0zA-3nk7A:29.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx4 | PUTATIVEOXIDOREDUCTASE (Salmonellaenterica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 296GLY A 317ILE A 298SER A 38LEU A 39 | None | 1.04A | 5l0zA-3nx4A:undetectable | 5l0zA-3nx4A:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohg | UNCHARACTERIZEDPROTEIN FROM DUF2233FAMILY (Bacteroidesovatus) |
PF09992(NAGPA) | 5 | GLY A 271GLY A 272ILE A 78GLN A 76LEU A 249 | NoneSO4 A 402 (-3.6A)NoneNoneNone | 0.94A | 5l0zA-3ohgA:undetectable | 5l0zA-3ohgA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3onp | TRNA/RRNAMETHYLTRANSFERASE(SPOU) (Rhodobactersphaeroides) |
PF00588(SpoU_methylase) | 5 | THR A 80GLY A 116GLY A 121LEU A 145LEU A 147 | BME A 251 ( 4.4A)ACY A 250 (-4.5A)ACY A 250 (-3.5A)BME A 251 ( 3.9A)ACY A 250 ( 4.5A) | 0.70A | 5l0zA-3onpA:17.0 | 5l0zA-3onpA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxb | PUTATIVE XYLOSEISOMERASE (Rhodospirillumrubrum) |
PF01261(AP_endonuc_2) | 5 | THR A 70GLY A 113SER A 76LEU A 97ALA A 100 | None | 0.91A | 5l0zA-3qxbA:2.9 | 5l0zA-3qxbA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | GLY A 155GLY A 156SER A 193LEU A 197LEU A 199 | None | 1.04A | 5l0zA-3ut2A:undetectable | 5l0zA-3ut2A:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6m | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 6 | GLY A 253GLY A 274ILE A 249ASP A 153LEU A 198ALA A 233 | None | 1.28A | 5l0zA-3w6mA:undetectable | 5l0zA-3w6mA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wz2 | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09754(PAC2) | 5 | GLY A 27GLY A 180ILE A 153LEU A 175ALA A 114 | None | 0.94A | 5l0zA-3wz2A:2.1 | 5l0zA-3wz2A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 5 | THR A 426GLY A 253ILE A 549ASP A 228LEU A 318 | 1PE A1553 (-3.7A)None1PE A1553 ( 3.7A)NoneNone | 0.93A | 5l0zA-4be9A:undetectable | 5l0zA-4be9A:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bev | COPPER EFFLUX ATPASE (Legionellapneumophila) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 5 | GLY A 397GLY A 399LEU A 729LEU A 731ALA A 728 | None | 1.01A | 5l0zA-4bevA:4.1 | 5l0zA-4bevA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cng | SPOU RRNA METHYLASE (Sulfolobusacidocaldarius) |
PF00588(SpoU_methylase) | 7 | THR A 77GLY A 111GLY A 116ILE A 131LEU A 140LEU A 142ALA A 145 | SAH A1157 (-3.6A)SAH A1157 (-3.1A)SAH A1157 ( 3.2A)SAH A1157 (-3.6A)SAH A1157 (-3.8A)SAH A1157 ( 4.4A)SAH A1157 ( 3.7A) | 0.29A | 5l0zA-4cngA:19.1 | 5l0zA-4cngA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv6 | TRANSCRIPTIONALREGULATOR MNTR (Bacillussubtilis) |
PF01325(Fe_dep_repress)PF02742(Fe_dep_repr_C) | 5 | GLY A 66ILE A 28GLN A 12LEU A 16ALA A 23 | None | 1.03A | 5l0zA-4hv6A:undetectable | 5l0zA-4hv6A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdz | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Escherichiacoli) |
PF00588(SpoU_methylase) | 5 | GLY A 100GLY A 105ILE A 122LEU A 133ALA A 136 | None | 0.50A | 5l0zA-4kdzA:19.1 | 5l0zA-4kdzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdz | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Escherichiacoli) |
PF00588(SpoU_methylase) | 5 | GLY A 100GLY A 105ILE A 122SER A 130LEU A 133 | None | 0.93A | 5l0zA-4kdzA:19.1 | 5l0zA-4kdzA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw6 | PEROXIREDOXIN-1 (Ancylostomaceylanicum) |
PF00578(AhpC-TSA) | 5 | THR A 75GLY A 121ILE A 109GLN A 108ALA A 110 | None | 1.02A | 5l0zA-4kw6A:3.2 | 5l0zA-4kw6A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mca | GLYCEROLDEHYDROGENASE (Serratiaplymuthica) |
PF00465(Fe-ADH) | 5 | THR A 120GLY A 272GLY A 170ILE A 117LEU A 164 | None | 1.02A | 5l0zA-4mcaA:undetectable | 5l0zA-4mcaA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nar | PUTATIVE URONATEISOMERASE (Thermotogamaritima) |
PF09861(DUF2088) | 6 | GLY A 302ARG A 266ILE A 264ASP A 406SER A 409LEU A 410 | None | 1.10A | 5l0zA-4narA:undetectable | 5l0zA-4narA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv2 | VKORC1/THIOREDOXINDOMAIN PROTEIN (Synechococcussp.JA-2-3B'a(2-13)) |
PF07884(VKOR) | 5 | LEU A 143GLY A 28GLY A 30LEU A 84ALA A 87 | None | 0.89A | 5l0zA-4nv2A:undetectable | 5l0zA-4nv2A:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozs | ALPHA SOLENOIDPROTEIN (syntheticconstruct) |
PF12854(PPR_1)PF13041(PPR_2) | 5 | THR A 42GLY A 46LEU A 12LEU A 18ALA A 21 | None | 1.04A | 5l0zA-4ozsA:undetectable | 5l0zA-4ozsA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozs | ALPHA SOLENOIDPROTEIN (syntheticconstruct) |
PF12854(PPR_1)PF13041(PPR_2) | 5 | THR A 112GLY A 116LEU A 82LEU A 88ALA A 91 | None | 1.04A | 5l0zA-4ozsA:undetectable | 5l0zA-4ozsA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pd4 | CYTOCHROME B (Saccharomycescerevisiae) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 6 | GLY C 337GLY C 340ILE C 354GLN C 353SER C 284ALA C 355 | None | 1.27A | 5l0zA-4pd4C:undetectable | 5l0zA-4pd4C:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pjs | PENTATRICOPEPTIDEREPEAT PROTEIN (unidentified) |
PF13041(PPR_2) | 5 | THR A 218GLY A 222LEU A 188LEU A 194ALA A 197 | None | 1.04A | 5l0zA-4pjsA:undetectable | 5l0zA-4pjsA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pjs | PENTATRICOPEPTIDEREPEAT PROTEIN (unidentified) |
PF13041(PPR_2) | 5 | THR A 253GLY A 257LEU A 223LEU A 229ALA A 232 | None | 1.02A | 5l0zA-4pjsA:undetectable | 5l0zA-4pjsA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzk | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Bacillusanthracis) |
PF00588(SpoU_methylase) | 7 | GLY A 104GLY A 109ARG A 124ILE A 125SER A 133LEU A 134LEU A 136 | SAH A 201 (-3.1A)SAH A 201 (-3.3A)NoneSAH A 201 (-3.9A)SAH A 201 ( 3.8A)SAH A 201 (-4.2A)SAH A 201 ( 4.3A) | 0.59A | 5l0zA-4pzkA:18.9 | 5l0zA-4pzkA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6r | SPHINGOSINE-1-PHOSPHATE LYASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | THR A 519GLY A 521ILE A 511GLN A 510LEU A 466 | GOL A 902 (-4.5A)NoneGOL A 902 ( 4.7A)NoneGOL A 902 ( 4.6A) | 0.97A | 5l0zA-4q6rA:undetectable | 5l0zA-4q6rA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rg1 | C9ORF114 (Homo sapiens) |
PF02598(Methyltrn_RNA_3) | 5 | THR A 289GLY A 312GLY A 316GLN A 346ALA A 356 | SAH A 401 (-3.8A)SAH A 401 (-3.1A)SAH A 401 (-3.3A)SAH A 401 (-3.8A)SAH A 401 (-3.4A) | 0.63A | 5l0zA-4rg1A:11.7 | 5l0zA-4rg1A:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x68 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00144(Beta-lactamase) | 6 | THR A 346GLY A 348GLY A 229ILE A 88LEU A 366ALA A 351 | None | 1.41A | 5l0zA-4x68A:undetectable | 5l0zA-4x68A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 7 | THR A 79GLY A 114GLY A 119ILE A 134LEU A 143LEU A 145ALA A 148 | SAH A 301 (-3.4A)SAH A 301 (-2.9A)SAH A 301 (-3.2A)SAH A 301 (-3.9A)SAH A 301 (-3.8A)SAH A 301 ( 4.5A)SAH A 301 (-3.6A) | 0.40A | 5l0zA-4xboA:17.4 | 5l0zA-4xboA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 7 | THR A 79GLY A 114GLY A 119ILE A 134SER A 142LEU A 143ALA A 148 | SAH A 301 (-3.4A)SAH A 301 (-2.9A)SAH A 301 (-3.2A)SAH A 301 (-3.9A)SAH A 301 (-3.4A)SAH A 301 (-3.8A)SAH A 301 (-3.6A) | 0.79A | 5l0zA-4xboA:17.4 | 5l0zA-4xboA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrs | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 6 | LEU A 124GLY A 149GLY A 153ILE A 174LEU A 179ALA A 177 | NoneNoneSEB A 151 ( 4.0A)NoneNoneNone | 1.40A | 5l0zA-4zrsA:3.0 | 5l0zA-4zrsA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a42 | UNCHARACTERIZEDLIPOPROTEIN YFHM (Escherichiacoli) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF11974(MG1) | 5 | LEU A 527GLY A 590GLY A 525LEU A 491ALA A 604 | None | 1.02A | 5l0zA-5a42A:undetectable | 5l0zA-5a42A:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdi | CHAPERONIN 60B1 (Chlamydomonasreinhardtii) |
PF00118(Cpn60_TCP1) | 5 | GLY A 376GLY A 193ARG A 369ILE A 370ASP A 342 | None | 1.02A | 5l0zA-5cdiA:undetectable | 5l0zA-5cdiA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5co4 | PUTATIVE TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 7 | GLY B 101GLY B 106ILE B 120SER B 128LEU B 129LEU B 131ALA B 134 | MTA B 401 (-3.2A)MTA B 401 (-3.2A)MTA B 401 (-3.7A)MTA B 401 ( 3.9A)MTA B 401 (-4.3A)MTA B 401 ( 4.2A)MTA B 401 (-3.5A) | 0.47A | 5l0zA-5co4B:20.0 | 5l0zA-5co4B:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2h | BETA-LACTAMASE (Mycolicibacteriumsmegmatis) |
PF00144(Beta-lactamase) | 6 | THR A 311GLY A 313GLY A 196ILE A 56LEU A 331ALA A 316 | None | 1.43A | 5l0zA-5e2hA:undetectable | 5l0zA-5e2hA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmb | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Pseudomonasaeruginosa) |
PF00588(SpoU_methylase) | 6 | GLY A 115ILE A 135SER A 143LEU A 144LEU A 146ALA A 149 | None | 0.65A | 5l0zA-5gmbA:18.1 | 5l0zA-5gmbA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmb | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Pseudomonasaeruginosa) |
PF00588(SpoU_methylase) | 7 | THR A 79GLY A 115GLY A 120ILE A 135LEU A 144LEU A 146ALA A 149 | None | 0.52A | 5l0zA-5gmbA:18.1 | 5l0zA-5gmbA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gra | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Zymomonasmobilis) |
PF00588(SpoU_methylase) | 5 | THR A 81GLY A 114GLY A 119LEU A 145ALA A 148 | None | 0.62A | 5l0zA-5graA:17.7 | 5l0zA-5graA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gra | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Zymomonasmobilis) |
PF00588(SpoU_methylase) | 5 | THR A 81GLY A 114LEU A 143LEU A 145ALA A 148 | None | 0.58A | 5l0zA-5graA:17.7 | 5l0zA-5graA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gui | CHAPERONE PROTEINCLPC1, CHLOROPLASTIC (Arabidopsisthaliana) |
PF02861(Clp_N) | 5 | GLY A 132GLY A 134ILE A 106SER A 198LEU A 201 | NoneNoneNonePO4 A 301 (-2.5A)None | 1.02A | 5l0zA-5guiA:undetectable | 5l0zA-5guiA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i9g | PENTATRICOPEPTIDEREPEAT PROTEINDPPR-U8C2 (unidentified) |
PF12854(PPR_1)PF13041(PPR_2) | 5 | THR C 91GLY C 95LEU C 61LEU C 67ALA C 70 | U A -3 ( 4.1A)NoneNoneNoneNone | 1.02A | 5l0zA-5i9gC:undetectable | 5l0zA-5i9gC:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i9g | PENTATRICOPEPTIDEREPEAT PROTEINDPPR-U8C2 (unidentified) |
PF12854(PPR_1)PF13041(PPR_2) | 5 | THR C 126GLY C 130LEU C 96LEU C 102ALA C 105 | U A -2 ( 3.9A)NoneNoneNoneNone | 0.99A | 5l0zA-5i9gC:undetectable | 5l0zA-5i9gC:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i9g | PENTATRICOPEPTIDEREPEAT PROTEINDPPR-U8C2 (unidentified) |
PF12854(PPR_1)PF13041(PPR_2) | 5 | THR C 266GLY C 270LEU C 236LEU C 242ALA C 245 | U A 2 ( 3.9A)NoneNoneNoneNone | 1.00A | 5l0zA-5i9gC:undetectable | 5l0zA-5i9gC:21.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l0z | PROBABLE RNAMETHYLTRANSFERASE,TRMH FAMILY (Sinorhizobiummeliloti) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 12 | THR A 212LEU A 214GLY A 235GLY A 240ARG A 254ILE A 255GLN A 257ASP A 262SER A 263LEU A 264LEU A 266ALA A 269 | SAM A 304 (-3.7A)SAM A 304 (-4.3A)SAM A 304 (-3.2A)SAM A 304 (-3.4A)NoneSAM A 304 (-3.9A)SAM A 304 (-4.0A)SAM A 304 (-3.0A)SAM A 304 (-3.1A)SAM A 304 (-3.8A)SO4 A 303 (-4.4A)SAM A 304 (-3.6A) | 0.00A | 5l0zA-5l0zA:44.4 | 5l0zA-5l0zA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l38 | MSM0272 - RMMMICROCOMPARTMENTSHELL PROTEIN (Mycolicibacteriumsmegmatis) |
PF00936(BMC) | 5 | GLY A 13GLY A 41ILE A 9LEU A 71ALA A 65 | None | 1.01A | 5l0zA-5l38A:undetectable | 5l0zA-5l38A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnc | VACUOLAR TRANSPORTERCHAPERONE 4,COREHISTONE MACRO-H2A.1 (Saccharomycescerevisiae;Homo sapiens) |
PF01661(Macro)PF03105(SPX) | 5 | GLY A 313GLY A 315ASP A 353SER A 356ALA A 325 | None | 1.03A | 5l0zA-5lncA:undetectable | 5l0zA-5lncA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 5 | GLY A 931ILE A 882GLN A 886LEU A 450LEU A 452 | None | 0.99A | 5l0zA-5lq3A:undetectable | 5l0zA-5lq3A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mac | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE-OXYGENASE TYPE III (Methanococcoidesburtonii) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | GLY A 426ILE A 454LEU A 464LEU A 441ALA A 444 | None | 1.04A | 5l0zA-5macA:3.3 | 5l0zA-5macA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5orm | CPPR-TELO1 (syntheticconstruct) |
no annotation | 5 | THR A 290GLY A 294LEU A 260LEU A 266ALA A 269 | None | 1.04A | 5l0zA-5ormA:undetectable | 5l0zA-5ormA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u24 | PUTATIVEAMINOTRANSFERASE (Campylobacterjejuni) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 83ILE A 85LEU A 89LEU A 62ALA A 86 | NoneNoneNoneNone7SG A 402 ( 3.7A) | 0.98A | 5l0zA-5u24A:undetectable | 5l0zA-5u24A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrq | ANKYRINREPEAT-CONTAININGPROTEIN (Legionellapneumophila) |
no annotation | 5 | LEU A 160GLY A 96ASP A 151LEU A 89ALA A 101 | None | 0.98A | 5l0zA-5vrqA:undetectable | 5l0zA-5vrqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb7 | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
no annotation | 5 | THR A 312GLY A 316ILE A 292SER A 283LEU A 327 | None | 0.76A | 5l0zA-5xb7A:undetectable | 5l0zA-5xb7A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0c | NEROL DEHYDROGENASE (Persicariaminor) |
no annotation | 5 | GLY A 77ILE A 314ASP A 155LEU A 157ALA A 162 | None | 0.95A | 5l0zA-5z0cA:2.7 | 5l0zA-5z0cA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5za2 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 6 | THR A 318GLY A 320GLY A 202ILE A 62LEU A 338ALA A 323 | EPE A 405 (-4.1A)NoneNoneNoneNoneNone | 1.39A | 5l0zA-5za2A:undetectable | 5l0zA-5za2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bog | RNAPOLYMERASE-ASSOCIATED PROTEIN RAPA (Escherichiacoli) |
no annotation | 5 | LEU A 311GLY A 308ILE A 299LEU A 330ALA A 303 | None | 0.97A | 5l0zA-6bogA:undetectable | 5l0zA-6bogA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm7 | BETA-LACTAMASE (Aeromonasenteropelogenes) |
no annotation | 6 | THR A 316GLY A 318GLY A 200ILE A 60LEU A 336ALA A 321 | NoneSO4 A 403 (-3.5A)NoneNoneNoneNone | 1.32A | 5l0zA-6fm7A:undetectable | 5l0zA-6fm7A:undetectable |