SIMILAR PATTERNS OF AMINO ACIDS FOR 5KR2_C_ROCC101_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | LEU B 133ILE B 277GLY B 7PRO B 51ILE B 136 | None | 1.00A | 5kr2D-1bouB:undetectable | 5kr2D-1bouB:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d0b | INTERNALIN B (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4) | 5 | LEU A 110ASN A 108ILE A 82VAL A 91ILE A 88 | None | 1.05A | 5kr2D-1d0bA:undetectable | 5kr2D-1d0bA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxl | PARANEOPLASTICENCEPHALOMYELITISANTIGEN HUD (Homo sapiens) |
PF00076(RRM_1) | 5 | LEU A 186GLY A 167ILE A 156VAL A 200ILE A 198 | None | 1.01A | 5kr2D-1fxlA:undetectable | 5kr2D-1fxlA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0b | CELLULASE (Rhodothermusmarinus) |
PF01670(Glyco_hydro_12) | 5 | LEU A 5ASN A 23GLY A 205VAL A 36ILE A 34 | None | 1.11A | 5kr2D-1h0bA:undetectable | 5kr2D-1h0bA:17.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23GLY A 51PRO A 81VAL A 82 | A79 A 800 (-3.4A)A79 A 800 ( 3.8A)NoneA79 A 800 ( 3.9A)A79 A 800 (-4.5A) | 1.12A | 5kr2D-1hvcA:13.7 | 5kr2D-1hvcA:44.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-3.4A)A79 A 800 ( 3.8A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.74A | 5kr2D-1hvcA:13.7 | 5kr2D-1hvcA:44.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-3.6A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.56A | 5kr2D-1hvcA:13.7 | 5kr2D-1hvcA:44.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23GLY A 48PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.82A | 5kr2D-1hvcA:13.7 | 5kr2D-1hvcA:44.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1irx | LYSYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF01921(tRNA-synt_1f) | 5 | LEU A 301GLY A 272ILE A 273VAL A 302ILE A 305 | None | 1.14A | 5kr2D-1irxA:undetectable | 5kr2D-1irxA:10.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | LEU A 595ILE A 525GLY A 522VAL A 537ILE A 629 | None | 1.10A | 5kr2D-1j0nA:undetectable | 5kr2D-1j0nA:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji6 | PESTICIDIAL CRYSTALPROTEIN CRY3BB (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | LEU A 541ILE A 592ILE A 628VAL A 517ILE A 642 | None | 1.16A | 5kr2D-1ji6A:undetectable | 5kr2D-1ji6A:10.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lk5 | D-RIBOSE-5-PHOSPHATEISOMERASE (Pyrococcushorikoshii) |
PF06026(Rib_5-P_isom_A) | 5 | LEU A 161ILE A 200GLY A 202ILE A 141ILE A 180 | None | 1.11A | 5kr2D-1lk5A:undetectable | 5kr2D-1lk5A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 5 | LEU A 65GLY A 18PRO A 402VAL A 23ILE A 70 | None | 1.13A | 5kr2D-1lxyA:undetectable | 5kr2D-1lxyA:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9s | INTERNALIN B (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF09479(Flg_new)PF12354(Internalin_N)PF12799(LRR_4)PF13457(SH3_8) | 5 | LEU A 110ASN A 108ILE A 82VAL A 91ILE A 88 | None | 1.08A | 5kr2D-1m9sA:undetectable | 5kr2D-1m9sA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nba | N-CARBAMOYLSARCOSINEAMIDOHYDROLASE (Arthrobactersp.) |
PF00857(Isochorismatase) | 5 | ARG A 196LEU A 211ILE A 186ILE A 168ILE A 214 | None | 1.10A | 5kr2D-1nbaA:undetectable | 5kr2D-1nbaA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | LEU A 650GLY A 668ILE A 666VAL A 395ILE A 485 | ADP A1731 ( 4.6A)NoneNoneADP A1731 (-4.7A)None | 1.04A | 5kr2D-1o94A:undetectable | 5kr2D-1o94A:10.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oed | ACETYLCHOLINERECEPTOR PROTEIN,BETA CHAIN (Torpedomarmorata) |
PF02932(Neur_chan_memb) | 5 | LEU B 218ILE B 287ILE B 454VAL B 222ILE B 221 | None | 1.00A | 5kr2D-1oedB:undetectable | 5kr2D-1oedB:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q90 | APOCYTOCHROME F (Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 5 | LEU A 83ILE A 244ILE A 76VAL A 128ILE A 130 | None | 1.12A | 5kr2D-1q90A:undetectable | 5kr2D-1q90A:19.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.71A | 5kr2D-1sivA:18.4 | 5kr2D-1sivA:50.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf1 | NEGATIVE REGULATOROF ALLANTOIN ANDGLYOXYLATEUTILIZATION OPERONS (Escherichiacoli) |
PF01614(IclR) | 5 | LEU A 180GLY A 46ILE A 45VAL A 16ILE A 176 | None | 1.05A | 5kr2D-1tf1A:undetectable | 5kr2D-1tf1A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 5 | LEU A 350ILE A 305GLY A 235ILE A 317ILE A 232 | None | 1.10A | 5kr2D-1vheA:undetectable | 5kr2D-1vheA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | LEU A 166GLY A 178ILE A 102PRO A 169VAL A 168 | NoneFAD A1561 ( 3.8A)FAD A1561 (-3.7A)FAD A1561 (-4.7A)None | 1.10A | 5kr2D-1w1kA:undetectable | 5kr2D-1w1kA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wn1 | DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | LEU A 167ILE A 182GLY A 217ILE A 227VAL A 188 | None | 1.01A | 5kr2D-1wn1A:undetectable | 5kr2D-1wn1A:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr4 | PUTATIVE CITRATELYASE ALPHACHAIN/CITRATE-ACPTRANSFERASE (Salmonellaenterica) |
PF04223(CitF) | 5 | LEU A 460ILE A 250ILE A 258VAL A 442ILE A 440 | None | 1.09A | 5kr2D-1xr4A:undetectable | 5kr2D-1xr4A:12.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydx | TYPE I RESTRICTIONENZYME SPECIFICITYPROTEIN MG438 (Mycoplasmagenitalium) |
PF01420(Methylase_S) | 5 | ASN A 284ILE A 204GLY A 207VAL A 289ILE A 287 | None | 1.16A | 5kr2D-1ydxA:undetectable | 5kr2D-1ydxA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwa | ENDOGLUCANASE (Rhodothermusmarinus) |
PF01670(Glyco_hydro_12) | 5 | LEU A 5ASN A 23GLY A 205VAL A 36ILE A 34 | None | 1.08A | 5kr2D-2bwaA:undetectable | 5kr2D-2bwaA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bws | XAA-PROAMINOPEPTIDASE P (Escherichiacoli) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 5 | LEU A 433ILE A 403ILE A 259VAL A 424ILE A 430 | None | 1.04A | 5kr2D-2bwsA:undetectable | 5kr2D-2bwsA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | LEU A 46ILE A 101GLY A 104PRO A 92ILE A 7 | None | 1.08A | 5kr2D-2cevA:undetectable | 5kr2D-2cevA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | LEU A 316ILE A 376GLY A 357VAL A 343ILE A 347 | None | 0.80A | 5kr2D-2cunA:undetectable | 5kr2D-2cunA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5v | PYRANOSE 2-OXIDASE (Peniophora sp.SG) |
PF05199(GMC_oxred_C) | 5 | LEU A 329ASN A 325ILE A 77ILE A 51VAL A 286 | NoneNoneFAD A1625 (-3.9A)NoneNone | 1.12A | 5kr2D-2f5vA:undetectable | 5kr2D-2f5vA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8m | RIBOSE 5-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF06026(Rib_5-P_isom_A) | 5 | LEU A 42ILE A 83GLY A 24ILE A 53ILE A 38 | None | 1.16A | 5kr2D-2f8mA:undetectable | 5kr2D-2f8mA:16.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ILE A 53GLY A 55PRO A 86VAL A 87ILE A 89 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.66A | 5kr2D-2fmbA:14.9 | 5kr2D-2fmbA:33.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izo | FLAPSTRUCTURE-SPECIFICENDONUCLEASE (Sulfolobussolfataricus) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | ARG A 183ILE A 224GLY A 227ILE A 230ILE A 174 | None | 1.07A | 5kr2D-2izoA:undetectable | 5kr2D-2izoA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4m | UPF0146 PROTEINMTH_1000 (Methanothermobacterthermautotrophicus) |
PF03686(UPF0146) | 5 | LEU A 92GLY A 43ILE A 96VAL A 39ILE A 93 | None | 0.93A | 5kr2D-2k4mA:undetectable | 5kr2D-2k4mA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lnv | GENERAL SECRETIONPATHWAY PROTEIN C (Dickeyadadantii) |
PF11356(T2SSC) | 5 | LEU A 145ILE A 110GLY A 99PRO A 129ILE A 135 | None | 1.13A | 5kr2D-2lnvA:undetectable | 5kr2D-2lnvA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lnv | GENERAL SECRETIONPATHWAY PROTEIN C (Dickeyadadantii) |
PF11356(T2SSC) | 5 | LEU A 145ILE A 110PRO A 129VAL A 128ILE A 135 | None | 1.00A | 5kr2D-2lnvA:undetectable | 5kr2D-2lnvA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | ARG A 82GLY A 218ILE A 215PRO A 113VAL A 108 | None | 1.02A | 5kr2D-2pcrA:undetectable | 5kr2D-2pcrA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | ARG A 82ILE A 221ILE A 215PRO A 113VAL A 108 | None | 1.02A | 5kr2D-2pcrA:undetectable | 5kr2D-2pcrA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1d | 2-KETO-3-DEOXY-D-ARABINONATE DEHYDRATASE (Sulfolobussolfataricus) |
PF01557(FAA_hydrolase) | 5 | LEU X 266GLY X 222ILE X 258VAL X 272ILE X 212 | None | 1.17A | 5kr2D-2q1dX:undetectable | 5kr2D-2q1dX:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qu8 | PUTATIVE NUCLEOLARGTP-BINDING PROTEIN1 (Plasmodiumfalciparum) |
PF06858(NOG1) | 5 | ILE A 136GLY A 36ILE A 115VAL A 111ILE A 145 | None | 1.04A | 5kr2D-2qu8A:undetectable | 5kr2D-2qu8A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7m | 5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL5'-MONOPHOSPHATESYNTHETASE (Methanocaldococcusjannaschii) |
PF06849(DUF1246)PF06973(DUF1297) | 5 | ILE A 7ILE A 291PRO A 91VAL A 90ILE A 88 | None | 0.91A | 5kr2D-2r7mA:undetectable | 5kr2D-2r7mA:15.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.45A | 5kr2D-2rkfA:20.8 | 5kr2D-2rkfA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w20 | SIALIDASE A (Streptococcuspneumoniae) |
PF13088(BNR_2) | 5 | LEU A 536GLY A 613ILE A 585VAL A 558ILE A 554 | None | 1.01A | 5kr2D-2w20A:undetectable | 5kr2D-2w20A:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj4 | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] 1 (Homo sapiens) |
PF01380(SIS) | 5 | ILE A 634ILE A 592PRO A 615VAL A 588ILE A 589 | None | 0.97A | 5kr2D-2zj4A:undetectable | 5kr2D-2zj4A:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ail | 303AA LONGHYPOTHETICALESTERASE (Sulfurisphaeratokodaii) |
PF07859(Abhydrolase_3) | 5 | ARG A 221LEU A 162ILE A 50GLY A 52VAL A 121 | PO4 A 306 (-2.8A)NoneNoneNoneNone | 0.96A | 5kr2D-3ailA:undetectable | 5kr2D-3ailA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7m | CELLULASE (Rhodothermusmarinus) |
PF01670(Glyco_hydro_12) | 5 | LEU A 5ASN A 23GLY A 196VAL A 36ILE A 34 | None | 1.10A | 5kr2D-3b7mA:undetectable | 5kr2D-3b7mA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8y | ENDO-PECTATE LYASE (Dickeyachrysanthemi) |
PF03211(Pectate_lyase) | 5 | LEU A 153ILE A 206GLY A 209ILE A 188ILE A 175 | None | 1.12A | 5kr2D-3b8yA:undetectable | 5kr2D-3b8yA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clj | PROTEIN NRD1 (Saccharomycescerevisiae) |
PF04818(CTD_bind) | 5 | LEU A 108GLY A 73ILE A 72VAL A 104ILE A 105 | None | 1.12A | 5kr2D-3cljA:undetectable | 5kr2D-3cljA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efb | PROBABLE SOR-OPERONREGULATOR (Shigellaflexneri) |
PF04198(Sugar-bind) | 5 | LEU A 57GLY A 230ILE A 231VAL A 63ILE A 157 | None | 1.13A | 5kr2D-3efbA:undetectable | 5kr2D-3efbA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | ARG A 517LEU A 518ILE A 440GLY A 365ILE A 520 | None | 1.03A | 5kr2D-3fedA:undetectable | 5kr2D-3fedA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0m | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1 (Schizosaccharomycespombe) |
PF00498(FHA) | 5 | ILE A 52GLY A 137ILE A 138VAL A 191ILE A 17 | None | 0.93A | 5kr2D-3i0mA:undetectable | 5kr2D-3i0mA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzl | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriamonocytogenes) |
PF06838(Met_gamma_lyase) | 5 | LEU A 114GLY A 95ILE A 96VAL A 118ILE A 117 | None | 1.06A | 5kr2D-3jzlA:undetectable | 5kr2D-3jzlA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6r | SERINE RACEMASE (Homo sapiens) |
PF00291(PALP) | 5 | LEU A 180ILE A 160GLY A 162VAL A 197ILE A 193 | None | 1.15A | 5kr2D-3l6rA:undetectable | 5kr2D-3l6rA:14.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81VAL A 82 | None | 0.65A | 5kr2D-3mwsA:19.5 | 5kr2D-3mwsA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.44A | 5kr2D-3mwsA:19.5 | 5kr2D-3mwsA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s7i | ALLERGEN ARA H 1,CLONE P41B (Arachishypogaea) |
PF00190(Cupin_1) | 5 | ARG A 185ILE A 238ILE A 266VAL A 215ILE A 217 | None | 1.15A | 5kr2D-3s7iA:undetectable | 5kr2D-3s7iA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t32 | AMINOTRANSFERASE,CLASS I/II (Bacillusanthracis) |
PF00155(Aminotran_1_2) | 5 | ARG A 334LEU A 338ILE A 302VAL A 346ILE A 344 | None | 1.11A | 5kr2D-3t32A:undetectable | 5kr2D-3t32A:16.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81 | SO4 A 101 (-4.2A)None017 A 201 (-4.0A)017 A 201 (-3.3A)None | 0.71A | 5kr2D-3t3cA:18.3 | 5kr2D-3t3cA:73.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.46A | 5kr2D-3ttpA:19.5 | 5kr2D-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81 | NoneNone017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.55A | 5kr2D-3u7sA:20.0 | 5kr2D-3u7sA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzq | ACETOACETYL-COAREDUCTASE (Cupriavidusnecator) |
PF00106(adh_short) | 5 | LEU A 199GLY A 184ILE A 186VAL A 203ILE A 202 | None | 1.05A | 5kr2D-3vzqA:undetectable | 5kr2D-3vzqA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqy | ALANINE--TRNA LIGASE (Archaeoglobusfulgidus) |
PF01411(tRNA-synt_2c)PF02272(DHHA1)PF07973(tRNA_SAD) | 5 | LEU A 657ASN A 653GLY A 737ILE A 741ILE A 656 | None | 1.16A | 5kr2D-3wqyA:undetectable | 5kr2D-3wqyA:7.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | LEU A 145ILE A 122GLY A 72ILE A 149VAL A 68 | None | 0.79A | 5kr2D-4a9aA:undetectable | 5kr2D-4a9aA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4avo | BETA-1,4-EXOCELLULASE (Thermobifidafusca) |
PF01341(Glyco_hydro_6) | 5 | LEU A 178GLY A 313ILE A 315VAL A 217ILE A 219 | None | 0.83A | 5kr2D-4avoA:undetectable | 5kr2D-4avoA:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bof | ARGININE DEIMINASE (Streptococcuspyogenes) |
PF02274(Amidinotransf) | 5 | LEU A 61GLY A 14PRO A 405VAL A 19ILE A 66 | None | 1.05A | 5kr2D-4bofA:undetectable | 5kr2D-4bofA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cza | NA+/H+ ANTIPORTER,PUTATIVE (Pyrococcusabyssi) |
PF00999(Na_H_Exchanger) | 5 | LEU A 46GLY A 17ILE A 19VAL A 41ILE A 42 | None | 1.14A | 5kr2D-4czaA:undetectable | 5kr2D-4czaA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4j | ARGININE DEIMINASE (Mycoplasmapenetrans) |
PF02274(Amidinotransf) | 5 | LEU A 109GLY A 62PRO A 444VAL A 67ILE A 114 | None | 1.11A | 5kr2D-4e4jA:undetectable | 5kr2D-4e4jA:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ex9 | ALNA (Streptomycessp. CM020) |
PF04227(Indigoidine_A) | 5 | LEU A 9ILE A 87GLY A 108ILE A 110VAL A 68 | None | 1.00A | 5kr2D-4ex9A:undetectable | 5kr2D-4ex9A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe9 | OUTER MEMBRANEPROTEIN SUSF (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE)PF17142(DUF5115) | 5 | LEU A 387ILE A 453GLY A 482VAL A 427ILE A 429 | None | 1.15A | 5kr2D-4fe9A:undetectable | 5kr2D-4fe9A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gt6 | CELL SURFACE PROTEIN (Faecalibacteriumprausnitzii) |
PF13306(LRR_5) | 5 | LEU A 148ILE A 80GLY A 105VAL A 151ILE A 147 | None | 1.15A | 5kr2D-4gt6A:undetectable | 5kr2D-4gt6A:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h0o | ACETATE KINASE (Entamoebahistolytica) |
PF00871(Acetate_kinase) | 5 | LEU A 183GLY A 208ILE A 195VAL A 179ILE A 180 | None | 0.99A | 5kr2D-4h0oA:undetectable | 5kr2D-4h0oA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jn7 | ENOLASE (Agrobacteriumtumefaciens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 23ILE A 266GLY A 270ILE A 86VAL A 21 | None | 1.16A | 5kr2D-4jn7A:undetectable | 5kr2D-4jn7A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lik | DNA PRIMASE SMALLSUBUNIT (Homo sapiens) |
PF01896(DNA_primase_S) | 5 | LEU A 336GLY A 164ILE A 110VAL A 339ILE A 334 | None | 0.86A | 5kr2D-4likA:undetectable | 5kr2D-4likA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn8 | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 776ASN A 779GLY A 736ILE A 714VAL A 762 | None | 1.16A | 5kr2D-4mn8A:undetectable | 5kr2D-4mn8A:10.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-3.2A)NoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.54A | 5kr2D-4njvA:20.4 | 5kr2D-4njvA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7h | GLUTATHIONES-TRANSFERASE (Rhodospirillumrubrum) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 170ILE A 130PRO A 180VAL A 179ILE A 173 | None | 1.11A | 5kr2D-4o7hA:undetectable | 5kr2D-4o7hA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p9n | CARBOXYLESTERASE (Sulfolobusshibatae) |
PF07859(Abhydrolase_3) | 5 | ARG A 221LEU A 163ILE A 51GLY A 53VAL A 122 | None | 0.98A | 5kr2D-4p9nA:undetectable | 5kr2D-4p9nA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pv4 | PROLINEAMINOPEPTIDASE P II (Yersinia pestis) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 5 | LEU A 432ILE A 402ILE A 257VAL A 423ILE A 429 | None | 1.05A | 5kr2D-4pv4A:undetectable | 5kr2D-4pv4A:13.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7s | PRE-MRNA-SPLICINGATP-DEPENDENT RNAHELICASE PRP28 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 359ILE A 294ILE A 259VAL A 362ILE A 358 | None | 1.15A | 5kr2D-4w7sA:undetectable | 5kr2D-4w7sA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 526ILE A 628ILE A 609VAL A 523ILE A 527 | None | 1.13A | 5kr2D-4xcuA:undetectable | 5kr2D-4xcuA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | ILE A 187GLY A 205ILE A 206VAL A 214ILE A 249 | None | 0.95A | 5kr2D-4ywlA:undetectable | 5kr2D-4ywlA:20.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASN A 25GLY A 49PRO A 81ILE A 84 | None | 1.10A | 5kr2D-5b18A:17.9 | 5kr2D-5b18A:71.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlq | EXPORTIN-4 (Mus musculus) |
no annotation | 5 | LEU B 608ILE B 578ILE B 660VAL B 604ILE B 605 | None | 1.07A | 5kr2D-5dlqB:undetectable | 5kr2D-5dlqB:7.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dly | PLANTAZOLICINMETHYLTRANSFERASEBAML (Bacillusvelezensis) |
PF13847(Methyltransf_31) | 5 | LEU A 78ILE A 97ILE A 67VAL A 74ILE A 75 | None | 1.12A | 5kr2D-5dlyA:undetectable | 5kr2D-5dlyA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmh | UNCHARACTERIZEDPROTEIN CONSERVED INBACTERIA (Cupriavidusnecator) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | LEU A 179ILE A 106GLY A 232ILE A 236ILE A 208 | None | 1.15A | 5kr2D-5dmhA:undetectable | 5kr2D-5dmhA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtb | CG3822 (Drosophilamelanogaster) |
PF10613(Lig_chan-Glu_bd) | 5 | LEU A 242ASN A 238ILE A 91ILE A 96ILE A 241 | None | 0.98A | 5kr2D-5dtbA:undetectable | 5kr2D-5dtbA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs2 | REPEBODY (Escherichiacoli) |
PF11921(DUF3439)PF12354(Internalin_N)PF13855(LRR_8) | 5 | LEU B 75ASN B 73ILE B 47VAL B 56ILE B 53 | None | 1.15A | 5kr2D-5gs2B:undetectable | 5kr2D-5gs2B:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5il7 | RAB FAMILY PROTEIN (Chlorobaculumtepidum) |
PF12799(LRR_4)PF13516(LRR_6) | 5 | LEU A 415ASN A 413ILE A 342PRO A 387ILE A 383 | None | 1.13A | 5kr2D-5il7A:undetectable | 5kr2D-5il7A:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kk5 | CRISPR-ASSOCIATEDENDONUCLEASE CPF1 (Acidaminococcussp. BV3L6) |
no annotation | 5 | LEU A 66ILE A 121GLY A 112ILE A 111VAL A 69 | None | 1.03A | 5kr2D-5kk5A:undetectable | 5kr2D-5kk5A:6.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz9 | - (-) |
no annotation | 5 | LEU A 552GLY A 387ILE A 385VAL A 547ILE A 395 | None | 1.15A | 5kr2D-5mz9A:undetectable | 5kr2D-5mz9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9m | COBYRIC ACIDSYNTHASE (Staphylococcusaureus) |
no annotation | 5 | LEU A 203ILE A 135GLY A 177ILE A 178ILE A 199 | None | 1.11A | 5kr2D-5n9mA:undetectable | 5kr2D-5n9mA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nr1 | FTSZ-BINDING PROTEINFZLA (Caulobactervibrioides) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | LEU A 176GLY A 139PRO A 186VAL A 185ILE A 179 | None | 1.15A | 5kr2D-5nr1A:undetectable | 5kr2D-5nr1A:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1m | RUBBER OXYGENASE (Streptomycessp. K30) |
PF09995(DUF2236) | 5 | LEU A 79ASN A 76GLY A 70ILE A 67PRO A 94 | None | 1.17A | 5kr2D-5o1mA:undetectable | 5kr2D-5o1mA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy9 | GLYCOPROTEIN G (Indianavesiculovirus) |
no annotation | 5 | LEU A 374ILE A 319GLY A 321VAL A 366ILE A 368 | None | 1.12A | 5kr2D-5oy9A:undetectable | 5kr2D-5oy9A:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.44A | 5kr2D-5t2zA:20.1 | 5kr2D-5t2zA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT FWDG (Methanothermobacterwolfeii) |
PF12838(Fer4_7) | 5 | LEU G 60ILE G 76PRO G 23VAL G 24ILE G 45 | NoneSF4 G 101 ( 3.8A)NoneNoneSF4 G 102 ( 3.9A) | 1.07A | 5kr2D-5t5iG:undetectable | 5kr2D-5t5iG:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ud0 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Helicobacterpylori) |
no annotation | 5 | LEU A 44GLY A 63ILE A 67VAL A 77ILE A 46 | None | 1.17A | 5kr2D-5ud0A:undetectable | 5kr2D-5ud0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | LEU A 805ASN A 735GLY A 615VAL A 624ILE A 621 | None | 1.07A | 5kr2D-5um6A:undetectable | 5kr2D-5um6A:7.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fml | INO80 (Chaetomiumthermophilum) |
no annotation | 5 | LEU G1190ILE G 991GLY G 993ILE G 994ILE G1193 | None | 1.09A | 5kr2D-6fmlG:undetectable | 5kr2D-6fmlG:19.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.69A | 5kr2D-6upjA:18.1 | 5kr2D-6upjA:47.47 |