SIMILAR PATTERNS OF AMINO ACIDS FOR 5KQX_A_ROCA101_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | LEU B 133ILE B 277GLY B 7PRO B 51ILE B 136 | None | 1.05A | 5kqxB-1bouB:undetectable | 5kqxB-1bouB:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddg | SULFITE REDUCTASE(NADPH) FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | LEU A 241VAL A 401ILE A 439GLY A 277ILE A 261 | None | 1.08A | 5kqxB-1ddgA:undetectable | 5kqxB-1ddgA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkd | GROEL (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 222VAL A 276ILE A 325PRO A 279ILE A 250 | None | 1.10A | 5kqxB-1dkdA:undetectable | 5kqxB-1dkdA:21.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.4A)A79 A 800 ( 3.8A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.70A | 5kqxB-1hvcA:13.9 | 5kqxB-1hvcA:45.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.6A)A79 A 800 ( 4.0A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.68A | 5kqxB-1hvcA:13.9 | 5kqxB-1hvcA:45.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1la1 | GROEL (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 222VAL A 276ILE A 325PRO A 279ILE A 250 | None | 1.09A | 5kqxB-1la1A:undetectable | 5kqxB-1la1A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lk5 | D-RIBOSE-5-PHOSPHATEISOMERASE (Pyrococcushorikoshii) |
PF06026(Rib_5-P_isom_A) | 5 | LEU A 161ILE A 200GLY A 202ILE A 141ILE A 180 | None | 1.00A | 5kqxB-1lk5A:undetectable | 5kqxB-1lk5A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | LEU A 120VAL A 124ILE A 129ILE A 231ILE A 116 | None | 1.13A | 5kqxB-1mroA:undetectable | 5kqxB-1mroA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1poi | GLUTACONATE COENZYMEA-TRANSFERASE (Acidaminococcusfermentans) |
PF01144(CoA_trans) | 5 | VAL B 27ILE B 21GLY B 37ILE B 36ILE B 51 | None | 0.92A | 5kqxB-1poiB:undetectable | 5kqxB-1poiB:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rfz | HYPOTHETICAL PROTEINAPC35681 (Geobacillusstearothermophilus) |
PF04608(PgpA) | 5 | LEU A 157VAL A 54ILE A 104GLY A 147ILE A 119 | None | 1.12A | 5kqxB-1rfzA:undetectable | 5kqxB-1rfzA:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.68A | 5kqxB-1sivA:18.2 | 5kqxB-1sivA:50.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 389ASN A 342ILE A 262GLY A 264ILE A 343 | NAD A 501 ( 3.8A)NoneNoneNAD A 501 (-3.6A)NAD A 501 (-4.4A) | 1.10A | 5kqxB-1v8bA:undetectable | 5kqxB-1v8bA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wly | 2-HALOACRYLATEREDUCTASE (Burkholderiasp. WS) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 234VAL A 206ILE A 195GLY A 175ILE A 151 | LEU A 234 ( 0.6A)VAL A 206 ( 0.6A)ILE A 195 ( 0.7A)GLY A 175 ( 0.0A)ILE A 151 ( 0.7A) | 1.03A | 5kqxB-1wlyA:undetectable | 5kqxB-1wlyA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9i | LOW TEMPERATUREREQUIREMENT CPROTEIN (Listeriamonocytogenes) |
PF04608(PgpA) | 5 | LEU A 158VAL A 55ILE A 105GLY A 148ILE A 120 | None | 1.11A | 5kqxB-1y9iA:undetectable | 5kqxB-1y9iA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8x | DIHYDROLIPOYLDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 197ILE A 199GLY A 183ILE A 182ILE A 174 | NoneNoneNoneFAD A 480 (-4.2A)None | 1.14A | 5kqxB-2a8xA:undetectable | 5kqxB-2a8xA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afv | COBALAMINBIOSYNTHESISPRECORRIN ISOMERASE (Leptospirainterrogans) |
PF02570(CbiC) | 5 | ILE A 194GLY A 165ILE A 139PRO A 160ILE A 136 | None | 0.89A | 5kqxB-2afvA:undetectable | 5kqxB-2afvA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | LEU A 374VAL A 48ILE A 5ILE A 65ILE A 47 | None | 1.13A | 5kqxB-2bb0A:undetectable | 5kqxB-2bb0A:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | LEU A 46ILE A 101GLY A 104PRO A 92ILE A 7 | None | 0.99A | 5kqxB-2cevA:undetectable | 5kqxB-2cevA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 5 | LEU A 52VAL A 89ILE A 119ILE A 248ILE A 291 | None | 1.07A | 5kqxB-2cl2A:undetectable | 5kqxB-2cl2A:17.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | ARG A 8LEU A 23VAL A 32ILE A 53GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.5A)NoneNoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.64A | 5kqxB-2fmbA:14.9 | 5kqxB-2fmbA:33.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpq | BOTULINUM NEUROTOXIND LIGHT CHAIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | LEU A 192VAL A 45ILE A 91ILE A 97ILE A 158 | None | 0.99A | 5kqxB-2fpqA:undetectable | 5kqxB-2fpqA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izo | FLAPSTRUCTURE-SPECIFICENDONUCLEASE (Sulfolobussolfataricus) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | ARG A 183ILE A 224GLY A 227ILE A 230ILE A 174 | None | 1.06A | 5kqxB-2izoA:undetectable | 5kqxB-2izoA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3r | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 5 | LEU B 86VAL B 93ILE B 146GLY B 144ILE B 89 | None | 1.11A | 5kqxB-2j3rB:undetectable | 5kqxB-2j3rB:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3w | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 5 | LEU B 86VAL B 93ILE B 146GLY B 144ILE B 89 | None | 1.06A | 5kqxB-2j3wB:undetectable | 5kqxB-2j3wB:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ma4 | PUTATIVE PERIPLASMICPROTEIN (Salmonellaenterica) |
PF07338(DUF1471) | 5 | VAL A 70ILE A 43GLY A 83ILE A 81ILE A 24 | None | 1.13A | 5kqxB-2ma4A:undetectable | 5kqxB-2ma4A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyx | TRYPTOPHANHALOGENASE (Shewanellafrigidimarina) |
PF04820(Trp_halogenase) | 5 | LEU A 42VAL A 190GLY A 18ILE A 349ILE A 44 | None | 0.91A | 5kqxB-2pyxA:undetectable | 5kqxB-2pyxA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | LEU 1 245VAL 1 308ILE 1 193GLY 1 192ILE 1 222 | None | 1.09A | 5kqxB-2r6r1:undetectable | 5kqxB-2r6r1:15.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.49A | 5kqxB-2rkfA:20.4 | 5kqxB-2rkfA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | VAL A 152ILE A 132GLY A 130ILE A 74ILE A 29 | None | 1.03A | 5kqxB-2vcaA:undetectable | 5kqxB-2vcaA:7.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whl | BETA-MANNANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 157VAL A 85ILE A 69ILE A 107ILE A 122 | None | 1.11A | 5kqxB-2whlA:undetectable | 5kqxB-2whlA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whl | BETA-MANNANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 157VAL A 85ILE A 73ILE A 114ILE A 122 | None | 1.06A | 5kqxB-2whlA:undetectable | 5kqxB-2whlA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv1 | SUCCINYL-COA LIGASE[ADP-FORMING]SUBUNIT ALPHA (Methanocaldococcusjannaschii) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | LEU A 140VAL A 181ILE A 183GLY A 190ILE A 124 | None | 1.12A | 5kqxB-2yv1A:undetectable | 5kqxB-2yv1A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3adp | LAMBDA-CRYSTALLIN (Oryctolaguscuniculus) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ARG A 50LEU A 72VAL A 32GLY A 18ILE A 75 | None | 1.02A | 5kqxB-3adpA:undetectable | 5kqxB-3adpA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cia | COLD-ACTIVEAMINOPEPTIDASE (Colwelliapsychrerythraea) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | LEU A 595VAL A 624GLY A 583ILE A 582PRO A 590 | None | 1.08A | 5kqxB-3ciaA:undetectable | 5kqxB-3ciaA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ego | PROBABLE2-DEHYDROPANTOATE2-REDUCTASE (Bacillussubtilis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | ARG A 152ILE A 6GLY A 4ILE A 3ILE A 93 | None | 1.10A | 5kqxB-3egoA:undetectable | 5kqxB-3egoA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3k | UNCHARACTERIZEDPROTEIN YKR043C (Saccharomycescerevisiae) |
PF00300(His_Phos_1) | 5 | ARG A 181VAL A 173ILE A 155ILE A 186ILE A 10 | None | 0.91A | 5kqxB-3f3kA:undetectable | 5kqxB-3f3kA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3s | LAMBDA-CRYSTALLINHOMOLOG (Homo sapiens) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ARG A 50LEU A 72VAL A 32GLY A 18ILE A 75 | None | 1.06A | 5kqxB-3f3sA:undetectable | 5kqxB-3f3sA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | ARG A 517LEU A 518ILE A 440GLY A 365ILE A 520 | None | 1.10A | 5kqxB-3fedA:undetectable | 5kqxB-3fedA:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htn | PUTATIVE DNA BINDINGPROTEIN (Bacteroidesthetaiotaomicron) |
PF03479(DUF296) | 5 | LEU A 117VAL A 136GLY A 89ILE A 152ILE A 114 | None | 1.13A | 5kqxB-3htnA:undetectable | 5kqxB-3htnA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3v | PROBABLE SECRETEDSOLUTE-BINDINGLIPOPROTEIN (Streptomycescoelicolor) |
PF01547(SBP_bac_1) | 5 | LEU A 319ASN A 103GLY A 80PRO A 53ILE A 320 | None | 1.06A | 5kqxB-3i3vA:undetectable | 5kqxB-3i3vA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jug | BETA-MANNANASE (Bacillus sp.N16-5) |
PF00150(Cellulase) | 5 | LEU A 188VAL A 116ILE A 104ILE A 145ILE A 153 | None | 1.05A | 5kqxB-3jugA:undetectable | 5kqxB-3jugA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lov | PROTOPORPHYRINOGENOXIDASE (Exiguobacteriumsibiricum) |
PF01593(Amino_oxidase) | 5 | LEU A 387VAL A 358ILE A 54ILE A 402PRO A 397 | None | 1.11A | 5kqxB-3lovA:undetectable | 5kqxB-3lovA:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mt0 | UNCHARACTERIZEDPROTEIN PA1789 (Pseudomonasaeruginosa) |
PF00582(Usp) | 5 | LEU A 121VAL A 9ILE A 11GLY A 18ILE A 91 | None | 1.09A | 5kqxB-3mt0A:undetectable | 5kqxB-3mt0A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwe | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF16114(Citrate_bind) | 5 | LEU A 217VAL A 121ILE A 185GLY A 187ILE A 202 | None | 1.11A | 5kqxB-3mweA:undetectable | 5kqxB-3mweA:12.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.74A | 5kqxB-3mwsA:19.3 | 5kqxB-3mwsA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9u | THIOREDOXINREDUCTASE (Campylobacterjejuni) |
PF07992(Pyr_redox_2) | 5 | LEU A 14VAL A 290ILE A 46GLY A 58ILE A 59 | NoneFAD A 501 (-4.0A)FAD A 501 (-4.3A)NoneNone | 0.86A | 5kqxB-3r9uA:undetectable | 5kqxB-3r9uA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 5 | ARG A 214LEU A 236VAL A 33ILE A 41GLY A 39 | NoneNoneNDP A 601 ( 3.8A)NDP A 601 (-3.5A)None | 1.12A | 5kqxB-3rg9A:undetectable | 5kqxB-3rg9A:17.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | SO4 A 101 (-4.2A)NoneNone017 A 201 (-4.0A)017 A 201 (-3.3A)None | 0.62A | 5kqxB-3t3cA:18.3 | 5kqxB-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.44A | 5kqxB-3ttpA:19.3 | 5kqxB-3ttpA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u24 | PUTATIVE LIPOPROTEIN (Shewanellaoneidensis) |
PF05960(DUF885) | 5 | LEU A 567VAL A 351ILE A 430GLY A 432ILE A 356 | None | 1.13A | 5kqxB-3u24A:undetectable | 5kqxB-3u24A:11.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ILE A 47GLY A 49ILE A 50PRO A 81 | NoneNone017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.39A | 5kqxB-3u7sA:19.9 | 5kqxB-3u7sA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wn6 | ALPHA-AMYLASE (Oryza sativa) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | LEU A 377VAL A 395ILE A 365ILE A 336ILE A 391 | None | 1.12A | 5kqxB-3wn6A:undetectable | 5kqxB-3wn6A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlc | ER-DERIVED VESICLESPROTEIN ERV41 (Saccharomycescerevisiae) |
PF07970(COPIIcoated_ERV)PF13850(ERGIC_N) | 5 | LEU A 80VAL A 94ILE A 168GLY A 166ILE A 82 | None | 1.05A | 5kqxB-3zlcA:undetectable | 5kqxB-3zlcA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxu | MCM21 (Kluyveromyceslactis) |
PF09496(CENP-O) | 5 | LEU A 124VAL A 155ILE A 180ILE A 187ILE A 137 | None | 0.86A | 5kqxB-3zxuA:undetectable | 5kqxB-3zxuA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | ARG A 505VAL A 558GLY A 515ILE A 500ILE A 548 | None | 1.02A | 5kqxB-4a2lA:undetectable | 5kqxB-4a2lA:8.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emk | U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM5U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM7 (Schizosaccharomycespombe) |
PF01423(LSM) | 5 | LEU A 10VAL C 88ILE C 46GLY C 48ILE C 49 | None | 0.93A | 5kqxB-4emkA:undetectable | 5kqxB-4emkA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx5 | VON WILLEBRANDFACTOR TYPE A (Catenulisporaacidiphila) |
PF13768(VWA_3) | 5 | LEU A 161VAL A 96ILE A 148GLY A 146ILE A 59 | None | 1.13A | 5kqxB-4fx5A:undetectable | 5kqxB-4fx5A:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1k | TRIOSEPHOSPHATEISOMERASE (Burkholderiathailandensis) |
PF00121(TIM) | 5 | ARG A 248VAL A 63GLY A 11ILE A 233ILE A 42 | None | 1.01A | 5kqxB-4g1kA:undetectable | 5kqxB-4g1kA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2r | ACCD6,CARBOXYLTRANSFERASEBETA-SUBUNIT OFACYL-COA CARBOXYLASE (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | ARG A 37LEU A 33ILE A 90GLY A 92ILE A 93 | None | 1.08A | 5kqxB-4g2rA:undetectable | 5kqxB-4g2rA:13.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-3.2A)NoneNoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.67A | 5kqxB-4njvA:20.0 | 5kqxB-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | LEU A 396VAL A 76ILE A 381ILE A 87ILE A 394 | None | 0.89A | 5kqxB-4nkyA:undetectable | 5kqxB-4nkyA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1e | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Escherichiafergusonii) |
PF03480(DctP) | 5 | LEU A 143VAL A 90ILE A 42GLY A 45ILE A 241 | None | 1.10A | 5kqxB-4p1eA:undetectable | 5kqxB-4p1eA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pyr | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Chromobacteriumviolaceum) |
PF04348(LppC) | 5 | LEU A 166VAL A 88GLY A 107ILE A 337ILE A 146 | None | 0.80A | 5kqxB-4pyrA:undetectable | 5kqxB-4pyrA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3o | MGS-MT1 (unidentified) |
PF07859(Abhydrolase_3) | 5 | VAL A 94ILE A 138GLY A 141ILE A 144PRO A 109 | GOL A 405 (-4.4A)NoneNoneNoneNone | 1.09A | 5kqxB-4q3oA:undetectable | 5kqxB-4q3oA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa9 | GALA PROTEIN TYPE 1,3 OR 4 (Legionellapneumophila) |
PF13516(LRR_6) | 5 | LEU A 49VAL A 97ILE A 102GLY A 82ILE A 73 | None | 0.96A | 5kqxB-4xa9A:undetectable | 5kqxB-4xa9A:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk2 | ALDO/KETO REDUCTASE (Polaromonas sp.JS666) |
PF00248(Aldo_ket_red) | 5 | ARG A 116LEU A 117VAL A 152ILE A 155ILE A 122 | None | 1.14A | 5kqxB-4xk2A:undetectable | 5kqxB-4xk2A:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y81 | PROTEASOME SUBUNITBETA TYPE-6 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | ARG L 213VAL L 43ILE L 12GLY L 14ILE L 15 | None | 1.12A | 5kqxB-4y81L:undetectable | 5kqxB-4y81L:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9v | PARTICLE-ASSOCIATEDLYASE (Acinetobactervirus AP22) |
no annotation | 5 | LEU A 354VAL A 404GLY A 395ILE A 366ILE A 382 | None | 1.13A | 5kqxB-4y9vA:undetectable | 5kqxB-4y9vA:9.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ARG A 10LEU A 30VAL A 39GLY A 58ILE A 100 | NoneNoneNone4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.79A | 5kqxB-4ydfA:12.7 | 5kqxB-4ydfA:31.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | VAL A 221ILE A 187GLY A 205ILE A 206ILE A 249 | None | 1.10A | 5kqxB-4ywlA:undetectable | 5kqxB-4ywlA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a62 | PUTATIVE ALPHA/BETAHYDROLASE FOLDPROTEIN (CandidatusNitrososphaeragargensis) |
PF00561(Abhydrolase_1) | 5 | VAL A 251ILE A 122GLY A 97ILE A 29ILE A 38 | None | 1.08A | 5kqxB-5a62A:undetectable | 5kqxB-5a62A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ctm | BETA-LACTAMASE (Bacilluspumilus) |
PF00905(Transpeptidase) | 5 | LEU A 262VAL A 87GLY A 73ILE A 266PRO A 197 | None | 1.10A | 5kqxB-5ctmA:undetectable | 5kqxB-5ctmA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cw5 | BRCA1/BRCA2-CONTAINING COMPLEX SUBUNIT 3 (Camponotusfloridanus) |
PF01398(JAB) | 5 | LEU A 79VAL A 89GLY A 33ILE A 51ILE A 36 | None | 0.87A | 5kqxB-5cw5A:undetectable | 5kqxB-5cw5A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtb | CG3822 (Drosophilamelanogaster) |
PF10613(Lig_chan-Glu_bd) | 5 | LEU A 242ASN A 238ILE A 91ILE A 96ILE A 241 | None | 0.95A | 5kqxB-5dtbA:undetectable | 5kqxB-5dtbA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5n | LH3HEXON-INTERLACINGCAPSID PROTEIN (Snakeatadenovirus A) |
PF01696(Adeno_E1B_55K) | 5 | LEU A 49ILE A 86ILE A 83PRO A 37ILE A 68 | None | 1.12A | 5kqxB-5g5nA:undetectable | 5kqxB-5g5nA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gv1 | ENDO-1,4-BETA-XYLANASE (termite gutmetagenome) |
PF00457(Glyco_hydro_11) | 5 | ILE A 145GLY A 123ILE A 122PRO A 210ILE A 206 | None | 1.11A | 5kqxB-5gv1A:undetectable | 5kqxB-5gv1A:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gyg | ENDO-1,4-BETA-XYLANASE (termite gutmetagenome) |
PF00457(Glyco_hydro_11) | 5 | ILE A 145GLY A 123ILE A 122PRO A 210ILE A 206 | None | 1.12A | 5kqxB-5gygA:undetectable | 5kqxB-5gygA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 5 | LEU B1407ILE B1299GLY B1392ILE B1047ILE B1410 | None | 1.12A | 5kqxB-5gztB:undetectable | 5kqxB-5gztB:6.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzu | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 5 | LEU A1407ILE A1299GLY A1392ILE A1047ILE A1410 | None | 1.11A | 5kqxB-5gzuA:undetectable | 5kqxB-5gzuA:8.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7j | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 5 | LEU A 92ILE A 119GLY A 28ILE A 96ILE A 93 | None | 1.09A | 5kqxB-5h7jA:undetectable | 5kqxB-5h7jA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hab | RIBONUCLEASE J (Methanolobuspsychrophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | LEU A 137VAL A 160ILE A 31ILE A 102ILE A 145 | None | 1.12A | 5kqxB-5habA:undetectable | 5kqxB-5habA:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihe | DNA POLYMERASE IISMALL SUBUNIT (Pyrococcusabyssi) |
PF00149(Metallophos) | 5 | LEU A 488VAL A 199GLY A 447ILE A 401ILE A 486 | None | 1.02A | 5kqxB-5iheA:undetectable | 5kqxB-5iheA:12.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kd0 | AROMATICPRENYLTRANSFERASE (Aspergillusterreus) |
PF11991(Trp_DMAT) | 5 | LEU A 121ASN A 172ILE A 253GLY A 251ILE A 173 | None | 1.10A | 5kqxB-5kd0A:undetectable | 5kqxB-5kd0A:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcn | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF12146(Hydrolase_4) | 5 | LEU A 159VAL A 214ILE A 175ILE A 228ILE A 156 | None | 1.10A | 5kqxB-5lcnA:undetectable | 5kqxB-5lcnA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mnj | E3 UBIQUITIN-PROTEINLIGASE MDM2 (Homo sapiens) |
PF13920(zf-C3HC4_3) | 5 | VAL C 439GLY C 448ILE C 485PRO C 476ILE C 440 | None | 1.11A | 5kqxB-5mnjC:undetectable | 5kqxB-5mnjC:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mu3 | CENTRAL KINETOCHORESUBUNIT MCM21 (Kluyveromyceslactis) |
no annotation | 5 | LEU A 124VAL A 155ILE A 180ILE A 187ILE A 137 | None | 0.79A | 5kqxB-5mu3A:undetectable | 5kqxB-5mu3A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nno | ALDEHYDEDEHYDROGENASE (Trypanosomabrucei) |
PF00171(Aldedh) | 5 | LEU A 393VAL A 423ILE A 253GLY A 256ILE A 260 | NAD A 601 (-4.3A)NoneNoneNone92N A 602 ( 4.7A) | 1.09A | 5kqxB-5nnoA:undetectable | 5kqxB-5nnoA:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN S5, PUTATIVE (Trypanosomacruzi) |
no annotation | 5 | ASN O 134VAL O 102ILE O 28ILE O 52ILE O 137 | U E2147 ( 3.1A)NoneNoneNoneNone | 1.12A | 5kqxB-5optO:undetectable | 5kqxB-5optO:19.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.54A | 5kqxB-5t2zA:20.0 | 5kqxB-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc4 | BIFUNCTIONALMETHYLENETETRAHYDROFOLATEDEHYDROGENASE/CYCLOHYDROLASE,MITOCHONDRIAL (Homo sapiens) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | LEU A 45VAL A 180ILE A 251ILE A 305ILE A 183 | None | 0.99A | 5kqxB-5tc4A:undetectable | 5kqxB-5tc4A:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Naegleriagruberi) |
no annotation | 5 | VAL A 28ILE A 31GLY A 13ILE A 12ILE A 4 | NoneNoneNoneNAD A 401 (-4.1A)None | 0.93A | 5kqxB-5ur0A:undetectable | 5kqxB-5ur0A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7i | SERINEHYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | ARG A 425LEU A 381ASN A 379VAL A 354GLY A 257 | 8Z1 A 601 ( 3.8A)NoneNoneNoneNone | 1.09A | 5kqxB-5v7iA:undetectable | 5kqxB-5v7iA:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 386ASN A 339ILE A 259GLY A 261ILE A 340 | NAD A 501 (-3.9A)NoneNoneNAD A 501 (-3.6A)NAD A 501 (-4.4A) | 1.05A | 5kqxB-5v96A:undetectable | 5kqxB-5v96A:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0s | 60 KDA CHAPERONIN (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 222VAL A 276ILE A 325PRO A 279ILE A 250 | None | 1.04A | 5kqxB-5w0sA:undetectable | 5kqxB-5w0sA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvr | KLLA0C04147P (Kluyveromyceslactis) |
PF01237(Oxysterol_BP) | 5 | VAL A 909ILE A1041GLY A1058ILE A1070ILE A 906 | None | 1.00A | 5kqxB-5wvrA:undetectable | 5kqxB-5wvrA:11.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ej2 | BETA-SECRETASE 1 (Homo sapiens) |
no annotation | 5 | LEU A 694VAL A 779GLY A 762ILE A 761ILE A 707 | None | 1.13A | 5kqxB-6ej2A:6.5 | 5kqxB-6ej2A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 5 | LEU A 6VAL A1100ILE A 412ILE A1092ILE A1110 | None | 1.08A | 5kqxB-6en4A:undetectable | 5kqxB-6en4A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fml | INO80 (Chaetomiumthermophilum) |
no annotation | 5 | LEU G1190ILE G 991GLY G 993ILE G 994ILE G1193 | None | 1.00A | 5kqxB-6fmlG:undetectable | 5kqxB-6fmlG:18.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ARG A 8LEU A 23GLY A 49ILE A 50ILE A 84 | NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.78A | 5kqxB-6upjA:17.9 | 5kqxB-6upjA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23GLY A 49ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.75A | 5kqxB-6upjA:17.9 | 5kqxB-6upjA:48.48 |