SIMILAR PATTERNS OF AMINO ACIDS FOR 5KPR_A_PAUA404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 GLY A 154
SER A 190
ARG A 186
GLY A 157
 1BH  A 300 (-3.5A)
None
None
None
 1.13A 5kprA-1bh6A:
undetectable		 5kprA-1bh6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 GLU A 143
GLY A  12
ARG A 171
GLY A  15
 None
 0.86A 5kprA-1hyqA:
undetectable		 5kprA-1hyqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		4 GLU A  80
GLY A  30
SER A   5
GLY A   6
 GOL  A 209 (-3.1A)
GOL  A 209 (-3.7A)
GOL  A 209 ( 4.2A)
None
 1.11A 5kprA-1k26A:
undetectable		 5kprA-1k26A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLU A 303
GLY A 565
SER A 572
GLY A 574
 None
 1.09A 5kprA-1ksiA:
undetectable		 5kprA-1ksiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLU A 805
SER A 699
ARG A 695
GLY A 333
 None
 1.08A 5kprA-1mhsA:
undetectable		 5kprA-1mhsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		4 GLU A 146
SER A  25
ARG A  64
GLY A  26
 None
 0.99A 5kprA-1of3A:
undetectable		 5kprA-1of3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		4 GLY A 279
SER A 282
ARG A  74
GLY A 254
 None
None
SO3  A1374 (-2.0A)
SO3  A1374 (-3.3A)
 0.98A 5kprA-1okgA:
undetectable		 5kprA-1okgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 GLU A 147
GLY A  85
SER A 111
GLY A 109
 None
None
MCA  A4001 (-3.7A)
MCA  A4001 (-3.0A)
 0.89A 5kprA-1on9A:
undetectable		 5kprA-1on9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 GLU A 292
GLY A 167
SER A  35
GLY A  64
 None
PO4  A1352 (-3.6A)
PO4  A1352 (-2.8A)
PO4  A1352 (-3.4A)
 1.07A 5kprA-1pc3A:
undetectable		 5kprA-1pc3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A 586
SER A 560
ARG A 530
GLY A 559
 None
 1.03A 5kprA-1pguA:
undetectable		 5kprA-1pguA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 GLU A 174
GLY A 349
SER A 376
GLY A 374
 None
 1.07A 5kprA-1phpA:
undetectable		 5kprA-1phpA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLU A 393
SER A 409
ARG A 404
GLY A 407
 FAD  A1656 ( 3.6A)
FAD  A1656 (-2.7A)
FUM  A1657 ( 2.7A)
FAD  A1656 ( 3.0A)
 0.92A 5kprA-1qlbA:
undetectable		 5kprA-1qlbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 GLY A 154
SER A 190
ARG A 186
GLY A 157
 None
 1.12A 5kprA-1scjA:
1.8		 5kprA-1scjA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE
F1-ATPASE

(Bacillus sp.
PS3;
Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU B 202
GLY B 199
SER B 229
GLY E 286
 None
 1.11A 5kprA-1skyB:
undetectable		 5kprA-1skyB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		4 GLU A 373
GLY A 399
ARG A 377
GLY A 396
 645  A 501 ( 2.8A)
645  A 501 (-4.2A)
None
None
 1.01A 5kprA-1tg5A:
undetectable		 5kprA-1tg5A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLU A 475
GLY A 442
SER A 303
GLY A 302
 None
None
None
MYR  A1001 ( 3.5A)
 1.13A 5kprA-1v26A:
undetectable		 5kprA-1v26A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5u SET BINDING FACTOR 1

(Mus musculus) 		PF00169
(PH) 		4 GLU A  11
GLY A   4
ARG A 105
GLY A   1
 None
 1.08A 5kprA-1v5uA:
undetectable		 5kprA-1v5uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvv CHITINASE C

(Streptomyces
griseus) 		PF00182
(Glyco_hydro_19) 		4 GLU A 251
GLY A 258
SER A 255
GLY A 233
 None
 0.98A 5kprA-1wvvA:
undetectable		 5kprA-1wvvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 GLU A 143
GLY A  81
SER A 107
GLY A 105
 None
 0.93A 5kprA-1x0uA:
undetectable		 5kprA-1x0uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		4 GLY A  46
SER A 113
ARG A 136
GLY A 112
 STX  A 401 (-3.6A)
STX  A 401 (-2.8A)
STX  A 401 (-2.8A)
STX  A 401 (-4.8A)
 1.05A 5kprA-1x2bA:
undetectable		 5kprA-1x2bA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN

(Bacillus cereus) 		PF05913
(DUF871) 		4 GLU A  65
GLY A   6
SER A  32
GLY A  30
 None
 1.12A 5kprA-1x7fA:
undetectable		 5kprA-1x7fA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE

(Acidaminococcus
fermentans) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLU A 264
GLY A  53
ARG A 235
GLY A  79
 None
 1.01A 5kprA-1xdwA:
undetectable		 5kprA-1xdwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csk SORTING NEXIN 12

(Homo sapiens) 		PF00787
(PX) 		4 GLU A 120
SER A 141
ARG A 121
GLY A 139
 None
 0.97A 5kprA-2cskA:
undetectable		 5kprA-2cskA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djr ZINC FINGER BED
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02892
(zf-BED) 		4 GLU A   9
GLY A  69
SER A  71
GLY A  72
 None
 0.98A 5kprA-2djrA:
undetectable		 5kprA-2djrA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLU A 462
GLY A 196
SER A 231
GLY A 232
 None
 1.14A 5kprA-2f2aA:
undetectable		 5kprA-2f2aA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 GLU A 101
GLY A 201
SER A 178
GLY A 179
 FMN  A1904 ( 4.7A)
FMN  A1904 (-3.3A)
FMN  A1904 (-3.2A)
FMN  A1904 (-3.4A)
 1.03A 5kprA-2gjnA:
undetectable		 5kprA-2gjnA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 GLU A 574
GLY A 854
ARG A 569
GLY A 566
 None
 1.07A 5kprA-2hg4A:
undetectable		 5kprA-2hg4A:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		4 GLY A 418
SER A 420
ARG A 432
GLY A 435
 ACO  A 796 (-3.2A)
ACO  A 796 (-2.8A)
ACO  A 796 (-3.2A)
ACO  A 796 ( 4.2A)
 0.25A 5kprA-2i7nA:
41.2		 5kprA-2i7nA:
76.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		4 GLY A 193
SER A 195
ARG A 207
GLY A 210
 ACO  A1604 (-3.2A)
ACO  A1604 (-2.6A)
ACO  A1604 (-3.2A)
ACO  A1604 ( 3.9A)
 0.18A 5kprA-2i7pA:
38.4		 5kprA-2i7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 GLU A  95
SER A 103
ARG A 155
GLY A 104
 None
 1.11A 5kprA-2ihyA:
undetectable		 5kprA-2ihyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		4 GLU A 299
GLY A 210
SER A 293
GLY A 208
 None
G4P  A1307 ( 3.7A)
None
None
 1.12A 5kprA-2j4rA:
5.6		 5kprA-2j4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 GLY A1112
SER A1004
ARG A 962
GLY A1005
 None
 1.07A 5kprA-2j7nA:
undetectable		 5kprA-2j7nA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 GLU A 417
GLY A 251
ARG A 262
GLY A 254
 None
 1.13A 5kprA-2n0sA:
undetectable		 5kprA-2n0sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		4 GLU A 286
GLY A  31
SER A 281
GLY A  77
 None
 1.10A 5kprA-2nunA:
undetectable		 5kprA-2nunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 GLU A 232
GLY A  51
ARG A 236
GLY A 218
 None
A3P  A 999 (-3.5A)
A3P  A 999 (-3.1A)
None
 1.09A 5kprA-2oq2A:
undetectable		 5kprA-2oq2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otp LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY A
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		4 GLU A  90
GLY A 160
SER A  14
GLY A  13
 None
 1.11A 5kprA-2otpA:
undetectable		 5kprA-2otpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 GLU A  69
GLY A  33
SER A  63
GLY A 146
 None
None
None
PO4  A 901 (-3.6A)
 1.09A 5kprA-2q9tA:
undetectable		 5kprA-2q9tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 GLU A 200
GLY A 210
SER A 212
GLY A 215
 None
 1.04A 5kprA-2rchA:
undetectable		 5kprA-2rchA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 288
GLY A 163
ARG A 292
GLY A  82
 MG  A1451 (-1.9A)
ANP  A1449 (-3.9A)
CL  A1452 (-3.0A)
None
 1.12A 5kprA-2vpqA:
3.3		 5kprA-2vpqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 1.03A 5kprA-2wu5A:
undetectable		 5kprA-2wu5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLY A 452
SER A 495
ARG A 492
GLY A 496
 None
 0.95A 5kprA-3a24A:
undetectable		 5kprA-3a24A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 GLU A 460
GLY A 192
SER A 230
GLY A 231
 None
 1.13A 5kprA-3a2qA:
undetectable		 5kprA-3a2qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		4 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.79A 5kprA-3aarA:
5.2		 5kprA-3aarA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 GLY A 257
SER A 261
ARG A 192
GLY A 194
 None
 0.94A 5kprA-3ak5A:
undetectable		 5kprA-3ak5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		4 GLU A  26
GLY A 194
ARG A  22
GLY A  18
 None
 0.84A 5kprA-3e5mA:
undetectable		 5kprA-3e5mA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9u NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 GLY A 582
SER A 552
ARG A 681
GLY A 551
 None
 1.06A 5kprA-3e9uA:
undetectable		 5kprA-3e9uA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 GLU A 610
GLY A 206
SER A 204
GLY A 203
 GOL  A 764 (-2.8A)
None
GOL  A 764 (-3.5A)
None
 1.05A 5kprA-3eqnA:
undetectable		 5kprA-3eqnA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7j GLUTATHIONE
TRANSFERASE GST1-4

(Anopheles dirus) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLU A 116
GLY A 133
SER A 137
ARG A 113
 None
 1.13A 5kprA-3g7jA:
undetectable		 5kprA-3g7jA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		4 GLU A 135
GLY A 113
ARG A  65
GLY A  88
 None
 1.12A 5kprA-3g8qA:
undetectable		 5kprA-3g8qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 GLU A 165
GLY A 170
SER A 168
GLY A  76
 None
 1.11A 5kprA-3h6eA:
7.1		 5kprA-3h6eA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 146
SER A 148
ARG A 428
GLY A 141
 None
 0.98A 5kprA-3iayA:
undetectable		 5kprA-3iayA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcz INHIBITOR OF TRAP,
REGULATED BY T-BOX
(TRP) SEQUENCE RTPA

(Bacillus
licheniformis) 		PF15777
(Anti-TRAP) 		4 GLU A  22
GLY A  31
SER A  18
GLY A  17
 None
 1.15A 5kprA-3lczA:
undetectable		 5kprA-3lczA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		4 GLU A 115
GLY A 108
SER A 111
GLY A 308
 None
 0.99A 5kprA-3lmaA:
undetectable		 5kprA-3lmaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A  18
SER A  20
ARG A 348
GLY A  23
 None
 1.00A 5kprA-3lmdA:
undetectable		 5kprA-3lmdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		4 GLY A 308
SER A 303
ARG A  49
GLY A 304
 None
 1.10A 5kprA-3ndaA:
undetectable		 5kprA-3ndaA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 GLU A 119
GLY A 116
ARG A 161
GLY A 158
 None
 1.04A 5kprA-3nm1A:
2.8		 5kprA-3nm1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 343
GLY A 333
SER A 335
GLY A 234
 K  A 408 (-3.5A)
None
None
None
 1.05A 5kprA-3oytA:
undetectable		 5kprA-3oytA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		4 GLU A 298
GLY A 267
SER A 261
GLY A 233
 None
 1.00A 5kprA-3pzuA:
undetectable		 5kprA-3pzuA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 GLU A 368
GLY A 221
SER A 223
GLY A 226
 None
NAP  A 500 ( 3.8A)
None
None
 1.10A 5kprA-3rhdA:
undetectable		 5kprA-3rhdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwo GTP-BINDING PROTEIN
YPT32/YPT11

(Saccharomyces
cerevisiae) 		no annotation 4 GLU B  73
GLY B  20
SER B  22
GLY B  23
 None
None
None
GDP  B4032 (-3.4A)
 0.96A 5kprA-3rwoB:
undetectable		 5kprA-3rwoB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 342
GLY A 332
SER A 334
GLY A 231
 NA  A 410 (-3.1A)
None
None
None
 1.11A 5kprA-3u0fA:
undetectable		 5kprA-3u0fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 GLY A  14
SER A  12
ARG A  35
GLY A  10
 None
 0.93A 5kprA-3u9lA:
undetectable		 5kprA-3u9lA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 881
GLY A 836
SER A 885
GLY A 840
 None
 1.08A 5kprA-3va7A:
undetectable		 5kprA-3va7A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 GLU A  66
GLY A 110
SER A 112
GLY A 156
 None
 0.88A 5kprA-3w4rA:
1.0		 5kprA-3w4rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 GLU A  68
GLY A  33
SER A  62
GLY A 145
 None
None
None
PO4  A 401 (-3.6A)
 1.06A 5kprA-3w9vA:
undetectable		 5kprA-3w9vA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		4 GLY A  76
SER A  78
ARG A 161
GLY A 158
 None
None
OLC  A 504 (-3.6A)
None
 1.03A 5kprA-3wbnA:
undetectable		 5kprA-3wbnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 GLY A 244
SER A 280
ARG A 276
GLY A 247
 None
 1.10A 5kprA-3whiA:
undetectable		 5kprA-3whiA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 GLU A  66
GLY A 110
SER A 112
GLY A 156
 None
 0.96A 5kprA-3wl1A:
1.0		 5kprA-3wl1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A  92
GLY A 592
SER A  65
GLY A  64
 None
 1.14A 5kprA-4aipA:
undetectable		 5kprA-4aipA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 447
GLY A 381
ARG A 462
GLY A 443
 None
 0.94A 5kprA-4aipA:
undetectable		 5kprA-4aipA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		4 GLU A 237
GLY A 161
SER A  40
GLY A  69
 None
PO4  A 300 (-3.6A)
PO4  A 300 (-2.9A)
PO4  A 300 (-3.4A)
 1.07A 5kprA-4ecfA:
undetectable		 5kprA-4ecfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		4 GLY A 295
SER A 315
ARG A 343
GLY A 314
 FAD  A 602 (-3.4A)
None
None
None
 1.03A 5kprA-4eipA:
undetectable		 5kprA-4eipA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE

(Thermotoga
maritima) 		PF00578
(AhpC-TSA)
PF00881
(Nitroreductase) 		4 GLY A  36
SER A  40
ARG A 103
GLY A  39
 None
SO4  A 402 (-3.6A)
SO4  A 402 (-3.5A)
SO4  A 402 (-3.3A)
 1.14A 5kprA-4eo3A:
undetectable		 5kprA-4eo3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 GLU A  78
GLY A 128
SER A 121
GLY A 119
 None
 0.72A 5kprA-4j7qA:
undetectable		 5kprA-4j7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		4 GLU A 446
GLY A 365
ARG A 391
GLY A 264
 None
 1.14A 5kprA-4kssA:
undetectable		 5kprA-4kssA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 GLU A  66
GLY A 100
SER A  96
GLY A  95
 None
 1.08A 5kprA-4qgsA:
undetectable		 5kprA-4qgsA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		4 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.61A 5kprA-4rz2A:
3.9		 5kprA-4rz2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s36 PHAGE BASEPLATE
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 127
GLY A 124
SER A 138
GLY A 140
 None
 1.09A 5kprA-4s36A:
undetectable		 5kprA-4s36A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLU A  19
GLY A 297
ARG A  15
GLY A  11
 None
None
None
NDP  A1001 (-3.4A)
 0.92A 5kprA-4xb1A:
undetectable		 5kprA-4xb1A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLU A 253
GLY A 220
SER A 199
GLY A 200
 None
 1.14A 5kprA-4zviA:
undetectable		 5kprA-4zviA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A  53
SER A  55
ARG A 113
GLY A  71
 None
 0.99A 5kprA-4zy7A:
undetectable		 5kprA-4zy7A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 GLU A1016
SER A1019
ARG A1178
GLY A1024
 None
 0.93A 5kprA-5a22A:
undetectable		 5kprA-5a22A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5akr COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLU A  55
GLY A 315
ARG A  54
GLY A 225
 None
None
None
ACT  A 506 ( 3.4A)
 1.12A 5kprA-5akrA:
undetectable		 5kprA-5akrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 GLU A  51
GLY A 269
SER A 264
GLY A 263
 None
 1.08A 5kprA-5c54A:
undetectable		 5kprA-5c54A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.30A 5kprA-5e26A:
51.4		 5kprA-5e26A:
82.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elz TYPE II PANTOTHENATE
KINASE

(Staphylococcus
aureus) 		PF03630
(Fumble) 		5 GLU A  70
GLY A 100
SER A 102
ARG A 113
GLY A 116
 3V9  A 303 (-3.2A)
3V9  A 303 (-3.3A)
3V9  A 303 (-3.8A)
3V9  A 303 (-3.3A)
3V9  A 303 (-3.2A)
 0.54A 5kprA-5elzA:
29.8		 5kprA-5elzA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exp TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		4 GLU A 246
GLY A 174
SER A 176
GLY A 177
 None
None
None
SO4  A 401 ( 3.4A)
 1.08A 5kprA-5expA:
undetectable		 5kprA-5expA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLU A 418
GLY A 474
ARG A   5
GLY A   8
 None
 1.06A 5kprA-5f7sA:
undetectable		 5kprA-5f7sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 4 GLU A 687
GLY A 566
SER A 394
GLY A 393
 None
 1.08A 5kprA-5fodA:
undetectable		 5kprA-5fodA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqo SINGLE-STRANDED
DNA-BINDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF00436
(SSB) 		4 GLY A  73
SER A  75
ARG A 111
GLY A  12
 None
 0.98A 5kprA-5gqoA:
undetectable		 5kprA-5gqoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 881
GLY A 836
SER A 885
GLY A 840
 None
 1.07A 5kprA-5i8iA:
undetectable		 5kprA-5i8iA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 GLY A 283
SER A 264
ARG A 259
GLY A 263
 None
 1.03A 5kprA-5iclA:
undetectable		 5kprA-5iclA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 GLU A  69
GLY A  36
SER A  63
GLY A 150
 None
None
None
PO4  A 401 (-3.6A)
 1.08A 5kprA-5j1dA:
undetectable		 5kprA-5j1dA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 GLY A 209
SER A 213
ARG A 145
GLY A 147
 None
 0.89A 5kprA-5j44A:
undetectable		 5kprA-5j44A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 GLU A1086
GLY A1145
SER A1141
GLY A1124
 None
 1.15A 5kprA-5k50A:
undetectable		 5kprA-5k50A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mje CYTOTOXIC
TRANSLATIONAL
REPRESSOR OF
TOXIN-ANTITOXIN
STABILITY SYSTEM

(Vibrio cholerae) 		PF06296
(RelE) 		4 GLU A  23
GLY A  61
SER A  63
GLY A  83
 None
 0.89A 5kprA-5mjeA:
undetectable		 5kprA-5mjeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 GLU A 394
SER A 410
ARG A 405
GLY A 408
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.5A)
FUM  A 702 ( 3.0A)
FAD  A 701 ( 3.4A)
 0.85A 5kprA-5xmjA:
undetectable		 5kprA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLU A 684
GLY A 608
ARG A 680
GLY A 614
 None
 0.98A 5kprA-5zqzA:
0.8		 5kprA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 GLU A 117
GLY A  12
ARG A 274
GLY A 147
 FAD  A 502 (-3.3A)
FAD  A 502 (-3.2A)
FAD  A 502 (-4.1A)
FAD  A 502 (-3.0A)
 1.09A 5kprA-6cmzA:
undetectable		 5kprA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 4 GLU C 394
GLY C  94
SER C 278
GLY C 279
 None
 1.09A 5kprA-6f0kC:
undetectable		 5kprA-6f0kC:
undetectable