SIMILAR PATTERNS OF AMINO ACIDS FOR 5KPC_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		6 GLY A  15
GLY A  13
LEU A  45
VAL A  88
VAL A  20
LEU A  18
 None
NAP  A 360 (-3.3A)
None
None
None
None
 1.31A 5kpcA-1a27A:
5.6		 5kpcA-1a27A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		5 GLY A 182
GLY A  58
THR A 184
VAL A 104
ALA A  61
 None
 0.94A 5kpcA-1b65A:
undetectable		 5kpcA-1b65A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		5 GLY A   7
GLY A  19
LEU A  26
VAL A   5
LEU A   6
 None
 0.96A 5kpcA-1cfzA:
undetectable		 5kpcA-1cfzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		6 LEU A 375
VAL A 364
VAL A 379
ALA A 380
LEU A 382
ALA A 385
 None
 1.24A 5kpcA-1d2fA:
3.4		 5kpcA-1d2fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		5 GLY A 506
GLY A 512
LEU A 503
THR A 375
ALA A 115
 None
 0.75A 5kpcA-1ei5A:
undetectable		 5kpcA-1ei5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		5 GLY A 154
THR A 157
VAL A 205
ALA A 197
ALA A 110
 None
 0.90A 5kpcA-1iw8A:
undetectable		 5kpcA-1iw8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		5 GLY H   5
VAL H 137
VAL H 152
ALA H 151
LEU H 154
 None
 0.88A 5kpcA-1j2qH:
undetectable		 5kpcA-1j2qH:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		5 GLY A 101
GLY A  99
VAL A 127
LEU A 126
ALA A  70
 ADN  A 500 (-3.4A)
ADN  A 500 (-3.2A)
None
ADN  A 500 (-4.2A)
None
 0.94A 5kpcA-1jg3A:
9.1		 5kpcA-1jg3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		5 GLY A 128
GLY A  52
ALA A 131
LEU A 133
ALA A 136
 NDP  A 194 (-3.5A)
NDP  A 194 (-2.8A)
None
None
None
 0.89A 5kpcA-1juvA:
undetectable		 5kpcA-1juvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 GLY A 166
GLY A 168
LEU A 268
LEU A 163
ALA A 215
 None
 0.95A 5kpcA-1kq3A:
undetectable		 5kpcA-1kq3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 GLY A 196
VAL A 231
ALA A  52
LEU A  53
ALA A 121
 None
 0.90A 5kpcA-1m9uA:
undetectable		 5kpcA-1m9uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A 111
VAL A 152
VAL A 192
ALA A 134
LEU A 133
 None
 0.86A 5kpcA-1mb9A:
undetectable		 5kpcA-1mb9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		5 GLY A2298
LEU A2293
VAL A2249
LEU A2269
ALA A2264
 None
 0.93A 5kpcA-1mi1A:
undetectable		 5kpcA-1mi1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		5 GLY K 211
SER K  45
THR K 229
VAL K 200
ALA K 183
 None
 0.93A 5kpcA-1mkxK:
undetectable		 5kpcA-1mkxK:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZD

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		6 GLY A 149
LEU A  62
VAL A 173
ALA A 174
LEU A 172
ALA A 188
 None
None
None
None
None
BOG  A 250 (-4.6A)
 1.25A 5kpcA-1nf9A:
undetectable		 5kpcA-1nf9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		5 GLY A 219
THR A 331
THR A 339
ALA A 187
ALA A 209
 None
 0.95A 5kpcA-1o7xA:
undetectable		 5kpcA-1o7xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4x COATOMER GAMMA
SUBUNIT

(Homo sapiens) 		PF08752
(COP-gamma_platf)
PF16381
(Coatomer_g_Cpla) 		5 GLY A 832
LEU A 808
VAL A 842
LEU A 841
ALA A 775
 None
 0.96A 5kpcA-1r4xA:
undetectable		 5kpcA-1r4xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		6 GLY A 251
LEU A 257
THR A 145
VAL A 148
VAL A 367
LEU A 366
 None
 1.28A 5kpcA-1s1fA:
undetectable		 5kpcA-1s1fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		6 GLY A 206
GLY A 209
SER A 179
LEU A 175
VAL A 235
THR A 236
 None
 1.46A 5kpcA-1sfjA:
undetectable		 5kpcA-1sfjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		6 GLY A 473
LEU A 417
THR A 478
ALA A 410
LEU A 484
ALA A 487
 None
 1.43A 5kpcA-1sjpA:
undetectable		 5kpcA-1sjpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		5 GLY A  54
GLY A  97
ALA A  85
LEU A  84
ALA A  80
 None
 0.77A 5kpcA-1t5oA:
4.1		 5kpcA-1t5oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 GLY A 316
VAL A  50
VAL A 284
LEU A 277
ALA A 273
 PLP  A 962 (-3.4A)
None
None
None
None
 0.94A 5kpcA-1tdjA:
undetectable		 5kpcA-1tdjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Thermus
thermophilus) 		PF02219
(MTHFR) 		5 GLY A  54
GLY A  51
LEU A  78
THR A  56
ALA A  81
 None
 0.93A 5kpcA-1v93A:
undetectable		 5kpcA-1v93A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		6 GLY A 271
LEU A 314
THR A 267
VAL A 265
ALA A 276
ALA A 244
 None
 1.34A 5kpcA-1vcgA:
undetectable		 5kpcA-1vcgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 GLY A 272
GLY A 248
THR A 245
VAL A 242
VAL A 293
ALA A 288
 None
 1.45A 5kpcA-1vrdA:
undetectable		 5kpcA-1vrdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		5 GLY A 126
LEU A 132
VAL A 101
ALA A 102
LEU A 103
 None
 0.97A 5kpcA-1wdvA:
undetectable		 5kpcA-1wdvA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		5 GLY A  21
LEU A 113
VAL A 282
LEU A 281
ALA A  15
 None
 0.89A 5kpcA-1xc3A:
undetectable		 5kpcA-1xc3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydg TRP REPRESSOR
BINDING PROTEIN WRBA

(Deinococcus
radiodurans) 		PF03358
(FMN_red) 		5 GLY A  29
GLY A  33
VAL A 188
LEU A   7
ALA A  79
 None
 0.95A 5kpcA-1ydgA:
undetectable		 5kpcA-1ydgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 110
THR A 109
ALA A 304
LEU A 305
ALA A 309
 None
 0.87A 5kpcA-1zh8A:
undetectable		 5kpcA-1zh8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 GLY A 227
LEU A  35
VAL A  83
ALA A  82
LEU A  85
 None
 0.87A 5kpcA-2a4mA:
undetectable		 5kpcA-2a4mA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 GLY A 142
GLY A 161
VAL A 140
ALA A 109
LEU A 141
 None
 0.97A 5kpcA-2a5lA:
undetectable		 5kpcA-2a5lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 GLY A 118
GLY A 120
SER A 122
VAL A  15
ALA A  14
 None
 0.92A 5kpcA-2ag8A:
4.0		 5kpcA-2ag8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		6 GLY A 249
GLY A 251
VAL A 220
THR A 221
ALA A 262
ALA A 310
 None
COZ  A1365 (-3.6A)
None
None
None
None
 1.28A 5kpcA-2c6xA:
undetectable		 5kpcA-2c6xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9a RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00047
(ig)
PF00629
(MAM) 		5 GLY A  37
SER A  39
LEU A  85
VAL A 177
LEU A  89
 None
 0.93A 5kpcA-2c9aA:
undetectable		 5kpcA-2c9aA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 187
VAL A 220
ALA A 194
LEU A 193
ALA A 197
 None
 0.88A 5kpcA-2ctzA:
undetectable		 5kpcA-2ctzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 170
VAL A 124
VAL A 174
ALA A 175
LEU A 176
 None
 0.91A 5kpcA-2cvtA:
undetectable		 5kpcA-2cvtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 196
VAL A 351
THR A 352
ALA A 199
LEU A 197
 None
 0.90A 5kpcA-2dvlA:
undetectable		 5kpcA-2dvlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		5 GLY A 149
VAL A  72
VAL A  94
ALA A 143
LEU A 142
 None
 0.84A 5kpcA-2ea3A:
undetectable		 5kpcA-2ea3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		5 GLY A 212
VAL A 153
ALA A  65
LEU A  67
ALA A  70
 None
 0.87A 5kpcA-2g40A:
undetectable		 5kpcA-2g40A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		6 GLY A 192
LEU A 185
VAL A 226
THR A 227
ALA A 240
LEU A 239
 None
 1.33A 5kpcA-2gzsA:
undetectable		 5kpcA-2gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 235
GLY A 212
THR A 119
ALA A 233
ALA A 189
 None
 0.87A 5kpcA-2iwzA:
undetectable		 5kpcA-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 GLY A 179
VAL A  12
VAL A 115
ALA A 169
LEU A 168
 None
 0.87A 5kpcA-2j92A:
undetectable		 5kpcA-2j92A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		5 GLY A  68
VAL A 214
ALA A  62
LEU A  63
ALA A 224
 None
 0.92A 5kpcA-2jayA:
undetectable		 5kpcA-2jayA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lck MITOCHONDRIAL
UNCOUPLING PROTEIN 2

(Mus musculus) 		PF00153
(Mito_carr) 		6 LYS A 109
GLY A 117
GLY A 115
SER A 111
ALA A 122
LEU A 121
 None
 1.47A 5kpcA-2lckA:
undetectable		 5kpcA-2lckA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 GLY A 295
LEU A 266
VAL A 272
THR A 273
ALA A 259
LEU A 258
 None
 1.22A 5kpcA-2ldxA:
3.4		 5kpcA-2ldxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3a UPF0106 PROTEIN
AF_0751

(Archaeoglobus
fulgidus) 		PF01994
(Trm56) 		6 GLY A 142
VAL A   3
VAL A 135
ALA A 134
LEU A 137
ALA A  26
 None
 1.25A 5kpcA-2o3aA:
undetectable		 5kpcA-2o3aA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi8 PUTATIVE REGULATORY
PROTEIN SCO4313

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		6 GLY A  86
VAL A 134
THR A 131
ALA A  90
LEU A  92
ALA A  95
 None
 1.35A 5kpcA-2oi8A:
undetectable		 5kpcA-2oi8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A  45
VAL A 163
THR A 164
ALA A 189
LEU A 192
 None
 0.82A 5kpcA-2p6rA:
3.5		 5kpcA-2p6rA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 GLY A  66
GLY A  68
LEU A  72
VAL A 114
ALA A 135
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
None
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
 0.75A 5kpcA-2pxxA:
12.6		 5kpcA-2pxxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 GLY A  66
GLY A  68
SER A  70
LEU A  72
VAL A 114
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 ( 3.9A)
None
SAH  A 301 (-3.6A)
 0.95A 5kpcA-2pxxA:
12.6		 5kpcA-2pxxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		6 GLY A 145
LEU A 152
THR A 111
ALA A 175
LEU A 146
ALA A 178
 None
 1.22A 5kpcA-2q09A:
undetectable		 5kpcA-2q09A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		6 GLY A  12
GLY A  11
VAL A  15
ALA A  18
LEU A  17
ALA A 163
 FAD  A 401 ( 4.9A)
FAD  A 401 ( 3.3A)
FAD  A 401 ( 3.8A)
None
None
None
 1.42A 5kpcA-2q6uA:
undetectable		 5kpcA-2q6uA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 SER A 315
THR A 270
VAL A 259
THR A 258
ALA A 210
 None
 0.94A 5kpcA-2qk4A:
2.9		 5kpcA-2qk4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 315
GLY A 147
VAL A 273
LEU A 284
ALA A 280
 None
 0.94A 5kpcA-2qygA:
undetectable		 5kpcA-2qygA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY U 211
SER U  45
THR U 229
VAL U 200
ALA U 183
 None
 0.93A 5kpcA-2r2wU:
undetectable		 5kpcA-2r2wU:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		6 SER A  32
LEU A  50
VAL A 135
VAL A  42
LEU A  44
ALA A 142
 None
 1.31A 5kpcA-2r79A:
undetectable		 5kpcA-2r79A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  82
GLY A  84
THR A 105
VAL A 133
THR A 134
 SAM  A1248 (-3.3A)
SAM  A1248 (-3.4A)
SAM  A1248 (-4.5A)
SAM  A1248 (-3.4A)
SAM  A1248 (-3.8A)
 0.71A 5kpcA-2wa2A:
7.9		 5kpcA-2wa2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpw ORF14

(Streptomyces
clavuligerus) 		PF00583
(Acetyltransf_1) 		6 GLY A 281
LEU A 320
VAL A 271
ALA A 287
LEU A 284
ALA A 240
 None
 1.49A 5kpcA-2wpwA:
undetectable		 5kpcA-2wpwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		5 GLY A  91
LEU A  76
VAL A 152
VAL A 104
ALA A 105
 None
 0.92A 5kpcA-2x7mA:
undetectable		 5kpcA-2x7mA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvi ANKYRIN-1

(Homo sapiens) 		PF00531
(Death) 		5 SER A1443
LEU A1445
VAL A1449
ALA A1450
LEU A1451
 None
 0.91A 5kpcA-2yviA:
undetectable		 5kpcA-2yviA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 GLY A  58
VAL A 281
VAL A  63
ALA A  64
LEU A  65
ALA A 308
 None
 1.25A 5kpcA-2z1aA:
undetectable		 5kpcA-2z1aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 GLY A 233
VAL A 251
ALA A 239
LEU A 238
ALA A 243
 None
 0.94A 5kpcA-2ztuA:
5.2		 5kpcA-2ztuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 GLY A  23
GLY A  19
LEU A 113
VAL A 153
ALA A 289
 None
FAD  A 380 ( 4.4A)
None
None
None
 0.92A 5kpcA-3allA:
2.0		 5kpcA-3allA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 THR A  12
VAL A  54
ALA A  33
LEU A  34
ALA A  38
 None
 0.96A 5kpcA-3bdzA:
undetectable		 5kpcA-3bdzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 5 GLY A  12
GLY A   9
VAL A 136
VAL A 286
ALA A 285
 None
FAD  A 401 (-3.4A)
None
None
FAD  A 401 ( 4.5A)
 0.89A 5kpcA-3c4aA:
undetectable		 5kpcA-3c4aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 5 GLY B 194
LEU B 199
VAL B 127
VAL B 170
ALA B 169
 None
 0.91A 5kpcA-3c6qB:
undetectable		 5kpcA-3c6qB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  21
GLY A  17
VAL A 155
VAL A 339
ALA A 338
 None
FAD  A 500 ( 4.7A)
None
None
FAD  A 500 ( 3.8A)
 0.96A 5kpcA-3dh9A:
undetectable		 5kpcA-3dh9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A  62
LEU A  67
ALA A 204
LEU A 203
ALA A 199
 None
 0.89A 5kpcA-3e7dA:
undetectable		 5kpcA-3e7dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpp MACROLIDE-SPECIFIC
EFFLUX PROTEIN MACA

(Escherichia
coli) 		PF16576
(HlyD_D23) 		5 GLY A  90
THR A  74
THR A 199
VAL A 187
ALA A  66
 None
 0.93A 5kpcA-3fppA:
undetectable		 5kpcA-3fppA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 GLY A 153
LEU A 127
ALA A 136
LEU A 138
ALA A 141
 None
 0.96A 5kpcA-3gehA:
undetectable		 5kpcA-3gehA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu3 METHYLTRANSFERASE

(Bacillus cereus) 		PF13847
(Methyltransf_31) 		5 GLY A  47
GLY A  49
LEU A  53
THR A  99
ALA A 114
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.3A)
None
SAH  A 401 ( 4.0A)
SAH  A 401 (-4.4A)
 0.73A 5kpcA-3gu3A:
13.3		 5kpcA-3gu3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		6 GLY B  56
LEU B  50
THR B  65
VAL B  75
VAL B  92
LEU B  91
 None
None
ADI  B 425 (-3.0A)
None
None
None
 1.39A 5kpcA-3gv5B:
undetectable		 5kpcA-3gv5B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		6 GLY B  56
LEU B  50
THR B  65
VAL B  92
LEU B  91
ALA B  84
 None
None
ADI  B 425 (-3.0A)
None
None
None
 1.45A 5kpcA-3gv5B:
undetectable		 5kpcA-3gv5B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		5 GLY A  28
VAL A 200
ALA A 161
LEU A 160
ALA A 156
 None
 0.88A 5kpcA-3h07A:
undetectable		 5kpcA-3h07A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
ALPHA

(Methanocaldococcus
jannaschii) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		6 GLY A  40
LEU A 193
THR A 164
ALA A  50
LEU A  49
ALA A  78
 None
 1.42A 5kpcA-3h4pA:
undetectable		 5kpcA-3h4pA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 GLY A 127
GLY A 124
LEU A 160
VAL A 210
ALA A 298
 None
APC  A 359 (-3.0A)
None
None
None
 0.90A 5kpcA-3h9jA:
4.3		 5kpcA-3h9jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		6 GLY A 107
GLY A  66
LEU A  69
VAL A  85
ALA A 105
LEU A 106
 None
R5P  A 651 (-3.5A)
None
None
None
None
 1.30A 5kpcA-3heeA:
undetectable		 5kpcA-3heeA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 GLY B  50
GLY B  48
THR B  51
VAL B  70
ALA B  43
 None
MCN  B 921 (-3.5A)
None
None
None
 0.91A 5kpcA-3hrdB:
undetectable		 5kpcA-3hrdB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		5 GLY A 211
THR A 320
ALA A 293
LEU A 294
ALA A 297
 None
 0.97A 5kpcA-3ht4A:
undetectable		 5kpcA-3ht4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		6 GLY A   9
SER A 134
LEU A 135
ALA A  46
LEU A  47
ALA A  40
 None
 1.47A 5kpcA-3iuuA:
undetectable		 5kpcA-3iuuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S11,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		6 GLY K 171
GLY K 167
THR K 169
THR K 148
ALA K 137
ALA K 142
 None
 1.41A 5kpcA-3jd5K:
undetectable		 5kpcA-3jd5K:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 373
LEU A 390
VAL A 408
ALA A 407
ALA A 425
 None
 0.96A 5kpcA-3kdnA:
undetectable		 5kpcA-3kdnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzz SNAP-TAG

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 GLY A 177
LEU A 168
VAL A 164
ALA A 163
LEU A 162
 None
 0.95A 5kpcA-3kzzA:
undetectable		 5kpcA-3kzzA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		5 LEU A  48
THR A 151
VAL A  52
ALA A  53
LEU A  54
 None
 0.95A 5kpcA-3l93A:
3.0		 5kpcA-3l93A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lt3 POSSIBLE
MEMBRANE-ASSOCIATED
SERINE PROTEASE

(Mycobacterium
tuberculosis) 		PF13365
(Trypsin_2) 		6 GLY A 222
GLY A 344
THR A 221
VAL A 245
THR A 244
ALA A 266
 None
 1.38A 5kpcA-3lt3A:
undetectable		 5kpcA-3lt3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		6 GLY A  86
LEU A  73
VAL A  84
ALA A   4
LEU A  85
ALA A 131
 None
 1.30A 5kpcA-3lupA:
undetectable		 5kpcA-3lupA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 GLY A 128
VAL A 134
ALA A 135
LEU A 136
ALA A 189
 None
 0.92A 5kpcA-3m0gA:
undetectable		 5kpcA-3m0gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 LEU A 427
VAL A 416
VAL A 429
ALA A 399
LEU A 400
 None
 0.91A 5kpcA-3m6xA:
9.8		 5kpcA-3m6xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K 301
GLY K 353
VAL K 306
ALA K 299
ALA K 248
 None
 0.90A 5kpcA-3mvdK:
undetectable		 5kpcA-3mvdK:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		5 GLY A  76
GLY A 164
LEU A 171
VAL A  81
ALA A 134
 None
 0.92A 5kpcA-3n0tA:
undetectable		 5kpcA-3n0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noj 4-CARBOXY-4-HYDROXY-
2-OXOADIPATE
ALDOLASE/OXALOACETAT
E DECARBOXYLASE

(Pseudomonas
putida) 		PF03737
(RraA-like) 		5 LEU A  20
VAL A 180
ALA A  25
LEU A  26
ALA A 192
 None
 0.91A 5kpcA-3nojA:
undetectable		 5kpcA-3nojA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwc SMC PROTEIN

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 LEU A 539
VAL A 543
ALA A 544
LEU A 545
ALA A 613
 None
 0.73A 5kpcA-3nwcA:
undetectable		 5kpcA-3nwcA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus) 		PF08668
(HDOD) 		5 GLY A 157
LEU A 132
VAL A 136
ALA A 137
LEU A 138
 None
 0.74A 5kpcA-3p3qA:
undetectable		 5kpcA-3p3qA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		5 GLY A  14
GLY A  12
THR A  16
ALA A 184
LEU A 250
 None
 0.88A 5kpcA-3pg5A:
undetectable		 5kpcA-3pg5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		6 GLY A 107
GLY A  66
LEU A  69
VAL A  85
ALA A 105
LEU A 106
 None
RB5  A 150 (-3.7A)
None
None
None
None
 1.36A 5kpcA-3ph3A:
undetectable		 5kpcA-3ph3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 GLY N  78
SER N  84
LEU N  85
ALA N  48
LEU N  52
 LFA  N 488 ( 3.8A)
None
None
None
None
 0.89A 5kpcA-3rkoN:
undetectable		 5kpcA-3rkoN:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 GLY A  89
LEU A 353
VAL A 110
ALA A 132
LEU A 131
 None
 0.95A 5kpcA-3rv6A:
undetectable		 5kpcA-3rv6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		5 GLY A 140
VAL A 128
ALA A 127
LEU A 130
ALA A 105
 None
 0.75A 5kpcA-3s3rA:
undetectable		 5kpcA-3s3rA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		6 GLY A 176
LEU A 164
VAL A 344
THR A 347
VAL A 337
ALA A 336
 None
 1.45A 5kpcA-3sqiA:
undetectable		 5kpcA-3sqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		6 GLY A 283
THR A 285
THR A 292
ALA A 253
LEU A 255
ALA A 297
 None
 1.47A 5kpcA-3sqlA:
undetectable		 5kpcA-3sqlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE

(Azotobacter
vinelandii) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PHE A 185
SER A 184
ASN A  16
ASP A  17
 None
 1.43A 5kpcA-1a8pA:
3.5		 5kpcA-1a8pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 PHE A 209
SER A 208
ASN A 278
ASP A 280
 None
None
FAD  A 399 (-2.7A)
FAD  A 399 (-4.8A)
 1.38A 5kpcA-1efpA:
1.6		 5kpcA-1efpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 202
ASN A 144
GLN A 257
ASP A 142
 None
GEM  A 801 (-4.0A)
None
None
 1.31A 5kpcA-1h8lA:
0.2		 5kpcA-1h8lA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PHE A 329
SER A 313
ASN A 404
ASP A 403
 None
 1.34A 5kpcA-1iidA:
0.1		 5kpcA-1iidA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 562
ASN A 517
GLN A 582
ASP A 516
 ABL  A 901 ( 4.2A)
None
None
None
 1.25A 5kpcA-1naaA:
2.0		 5kpcA-1naaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qil TOXIC SHOCK SYNDROME
TOXIN-1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 PHE A  47
SER A  32
ASN A  37
GLN A  84
 None
 1.39A 5kpcA-1qilA:
0.0		 5kpcA-1qilA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 PHE A 240
SER A 239
ASN A 177
ASP A 308
 EDO  A1902 ( 4.5A)
None
None
None
 1.25A 5kpcA-1ukcA:
1.0		 5kpcA-1ukcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 SER A 299
ASN A 219
GLN A 324
ASP A 215
 None
 1.38A 5kpcA-1ulzA:
2.3		 5kpcA-1ulzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		4 PHE A 289
SER A 550
ASN A 267
ASP A 269
 None
 1.50A 5kpcA-1us2A:
0.4		 5kpcA-1us2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 197
ASN A 136
GLN A 249
ASP A 134
 None
 1.41A 5kpcA-1uwyA:
undetectable		 5kpcA-1uwyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 240
ASN A 136
GLN A 249
ASP A 134
 None
 1.45A 5kpcA-1uwyA:
undetectable		 5kpcA-1uwyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		4 PHE A 130
SER A 131
ASN A 220
ASP A 216
 None
 1.40A 5kpcA-1v6yA:
undetectable		 5kpcA-1v6yA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS

(Laetiporus
sulphureus) 		PF03318
(ETX_MTX2) 		4 PHE A  48
SER A  49
ASN A  28
GLN A  84
 None
 1.35A 5kpcA-1w3fA:
undetectable		 5kpcA-1w3fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 PHE A  37
SER A  40
ASN A1159
ASP A1158
 None
 1.32A 5kpcA-2boaA:
undetectable		 5kpcA-2boaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		4 SER A 344
ASN A  33
GLN A 264
ASP A  29
 None
 1.48A 5kpcA-2gljA:
undetectable		 5kpcA-2gljA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A  92
SER A  93
ASN A 223
ASP A 181
 None
HEM  A 486 ( 4.4A)
None
None
 1.45A 5kpcA-2isaA:
undetectable		 5kpcA-2isaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 290
SER A 285
ASN A  50
ASP A  52
 None
 1.02A 5kpcA-2nv9A:
undetectable		 5kpcA-2nv9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PHE A 112
SER A 111
ASN A 520
ASP A 373
 None
 1.38A 5kpcA-2obeA:
undetectable		 5kpcA-2obeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 PHE A 553
SER A 603
GLN A 502
ASP A 542
 None
 1.32A 5kpcA-2vz9A:
undetectable		 5kpcA-2vz9A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 PHE A 187
SER A 186
GLN A 142
ASP A   2
 None
GOL  A 668 ( 4.9A)
None
None
 1.50A 5kpcA-2zwsA:
undetectable		 5kpcA-2zwsA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 PHE A 702
ASN A 740
GLN A 703
ASP A 743
 None
 1.45A 5kpcA-3bwtA:
undetectable		 5kpcA-3bwtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		4 SER A  77
ASN A  95
GLN A  69
ASP A 153
 None
FLC  A 424 (-3.6A)
None
ZN  A 423 ( 2.4A)
 1.42A 5kpcA-3d6nA:
undetectable		 5kpcA-3d6nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		4 PHE A  58
SER A  59
GLN A  15
ASP A 135
 None
 1.44A 5kpcA-3gemA:
3.9		 5kpcA-3gemA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 PHE A  91
ASN A 173
GLN A 319
ASP A 223
 None
 0.86A 5kpcA-3h5tA:
undetectable		 5kpcA-3h5tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 PHE A 507
SER A 142
GLN A 504
ASP A 538
 None
 1.03A 5kpcA-3h7lA:
undetectable		 5kpcA-3h7lA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 SER A 369
ASN A 827
GLN A 401
ASP A 505
 None
 1.39A 5kpcA-3ihyA:
undetectable		 5kpcA-3ihyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		4 PHE D 123
SER D 157
ASN D 108
ASP D 104
 None
 1.21A 5kpcA-3j9eD:
undetectable		 5kpcA-3j9eD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 PHE A 564
SER A 563
ASN A 361
ASP A 431
 None
None
GOL  A 643 (-3.1A)
THH  A 642 (-3.3A)
 1.33A 5kpcA-3k13A:
undetectable		 5kpcA-3k13A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 PHE A  90
SER A 137
GLN A  94
ASP A  63
 None
SO4  A 207 (-4.4A)
None
None
 1.35A 5kpcA-3l4eA:
undetectable		 5kpcA-3l4eA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		4 PHE A 604
SER A 600
GLN A 553
ASP A 504
 None
 1.41A 5kpcA-3la6A:
undetectable		 5kpcA-3la6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbw EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		4 PHE A 156
SER A 154
ASN A 164
ASP A 148
 None
None
None
UNX  A 327 ( 2.7A)
 1.46A 5kpcA-3mbwA:
undetectable		 5kpcA-3mbwA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PHE A 359
SER A 357
ASN A 440
GLN A 459
 None
 1.29A 5kpcA-3nafA:
undetectable		 5kpcA-3nafA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		4 PHE A 143
SER A 144
ASN A 194
ASP A 195
 None
None
None
SO4  A 261 ( 4.5A)
 1.50A 5kpcA-3ozbA:
undetectable		 5kpcA-3ozbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1n GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
paracasei) 		PF01263
(Aldose_epim) 		4 PHE A  49
SER A  51
ASN A  97
GLN A  94
 None
 1.44A 5kpcA-3q1nA:
undetectable		 5kpcA-3q1nA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t20 CIS-ACONITATE PORIN
OPDH

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 SER A 281
ASN A 246
GLN A 208
ASP A 273
 None
 1.46A 5kpcA-3t20A:
undetectable		 5kpcA-3t20A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 PHE A 296
SER A 297
GLN A 183
ASP A  84
 NDP  A3001 (-3.7A)
None
NDP  A3001 (-3.8A)
None
 1.26A 5kpcA-3wg6A:
undetectable		 5kpcA-3wg6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew7 CONJUGATIVE
TRANSFER: REGULATION

(Salmonella
enterica) 		PF00989
(PAS) 		4 PHE A  74
SER A  77
ASN A  67
ASP A  58
 None
 1.29A 5kpcA-4ew7A:
undetectable		 5kpcA-4ew7A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 PHE A 161
SER A 158
GLN A 201
ASP A 170
 None
 1.19A 5kpcA-4g25A:
undetectable		 5kpcA-4g25A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 PHE A 236
SER A 237
ASN A 185
ASP A 257
 PGE  A 501 (-3.5A)
None
EDO  A 507 ( 4.7A)
None
 1.47A 5kpcA-4gl0A:
undetectable		 5kpcA-4gl0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		4 PHE A 265
SER A 264
GLN A 272
ASP A 281
 None
 1.34A 5kpcA-4hwgA:
undetectable		 5kpcA-4hwgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 4 PHE A 224
SER A 225
GLN A 306
ASP A  53
 None
 1.06A 5kpcA-4mc0A:
undetectable		 5kpcA-4mc0A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 PHE C 146
SER C 145
GLN C 153
ASP C   9
 None
0FX  C 301 ( 4.2A)
None
None
 1.31A 5kpcA-4nv1C:
undetectable		 5kpcA-4nv1C:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohj TOXIC SHOCK SYNDROME
TOXIN-1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 PHE A  87
SER A  72
ASN A  77
GLN A 124
 None
 1.37A 5kpcA-4ohjA:
undetectable		 5kpcA-4ohjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oro POLYMERASE PB2

(Influenza B
virus) 		PF00604
(Flu_PB2) 		4 PHE A 406
SER A 407
GLN A 437
ASP A 395
 GDP  A 501 (-4.2A)
None
None
None
 1.42A 5kpcA-4oroA:
undetectable		 5kpcA-4oroA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 PHE O 215
SER O 217
ASN O 247
ASP O 249
 None
 1.42A 5kpcA-5a31O:
undetectable		 5kpcA-5a31O:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 PHE A 773
SER A 768
ASN A 565
ASP A 563
 None
MGD  A1003 (-4.6A)
MD1  A1004 (-2.9A)
None
 1.37A 5kpcA-5chcA:
undetectable		 5kpcA-5chcA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		4 PHE A 154
SER A 139
ASN A 148
ASP A 145
 None
 1.29A 5kpcA-5fdaA:
undetectable		 5kpcA-5fdaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 PHE C  12
SER C  13
ASN C 155
ASP C 151
 None
 1.33A 5kpcA-5fmgC:
undetectable		 5kpcA-5fmgC:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		4 PHE A 263
SER A 259
GLN A 251
ASP A 205
 None
 1.32A 5kpcA-5h3xA:
undetectable		 5kpcA-5h3xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		4 PHE A 340
SER A 339
GLN A 317
ASP A 325
 None
BGC  A 604 ( 4.5A)
None
None
 1.38A 5kpcA-5j7zA:
undetectable		 5kpcA-5j7zA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzg CAPSID PROTEIN VP0

(Rhinovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 PHE C 129
SER C  87
GLN C 177
ASP C 133
 None
 1.46A 5kpcA-5jzgC:
undetectable		 5kpcA-5jzgC:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		5 PHE A  96
SER A  97
ASN A 159
GLN A 163
ASP A 185
 None
SAH  A 401 (-2.5A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
 0.51A 5kpcA-5kpgA:
53.7		 5kpcA-5kpgA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
CENTROMERE PROTEIN C

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF15622
(CENP_C_N) 		4 PHE A  79
SER A  80
ASN P  11
GLN A  29
 None
 1.13A 5kpcA-5lskA:
undetectable		 5kpcA-5lskA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 SER A  92
ASN A 218
GLN A 159
ASP A 217
 None
 1.09A 5kpcA-5m60A:
undetectable		 5kpcA-5m60A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 4 SER A  88
ASN A  55
GLN A  42
ASP A  59
 None
 1.35A 5kpcA-5oqpA:
undetectable		 5kpcA-5oqpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 PHE A1464
SER A1465
ASN A1175
ASP A1178
 None
 1.46A 5kpcA-5t8vA:
undetectable		 5kpcA-5t8vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 4 PHE A 513
SER A 514
ASN A 453
ASP A 895
 None
 1.33A 5kpcA-5txkA:
undetectable		 5kpcA-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 PHE A1090
ASN A  48
GLN A 151
ASP A  47
 None
 1.34A 5kpcA-5uakA:
undetectable		 5kpcA-5uakA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		4 PHE A 138
SER A 139
ASN B 263
ASP A 265
 None
 1.17A 5kpcA-5vocA:
undetectable		 5kpcA-5vocA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 PHE A 140
SER A 141
ASN A 200
ASP A 244
 None
 1.28A 5kpcA-5wblA:
undetectable		 5kpcA-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xea ENVELOPE
GLYCOPROTEIN

(Thogoto
thogotovirus) 		PF03273
(Baculo_gp64) 		4 SER A 180
ASN A 246
GLN A 258
ASP A 243
 None
 1.27A 5kpcA-5xeaA:
undetectable		 5kpcA-5xeaA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 4 SER A 351
ASN A 200
GLN A 190
ASP A 205
 None
None
FMN  A 401 (-3.9A)
None
 1.30A 5kpcA-6bkaA:
undetectable		 5kpcA-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 4 PHE E 613
SER E 615
ASN E 493
GLN E 416
 None
 1.41A 5kpcA-6c3pE:
undetectable		 5kpcA-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 PHE A 113
SER A 112
ASN A 169
ASP A 237
 None
 1.46A 5kpcA-6d8wA:
undetectable		 5kpcA-6d8wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejb XYLOSYLTRANSFERASE 1

(Homo sapiens) 		no annotation 4 PHE A 508
SER A 509
ASN A 499
ASP A 444
 None
 1.42A 5kpcA-6ejbA:
undetectable		 5kpcA-6ejbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 PHE A  83
SER A  58
GLN A 126
ASP A 116
 None
 1.41A 5kpcA-6f8zA:
undetectable		 5kpcA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 4 PHE A 552
SER A 551
ASN A 583
ASP A 557
 None
 1.42A 5kpcA-6fq3A:
undetectable		 5kpcA-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 4 SER A  99
ASN A 161
GLN A 165
ASP A 187
 SAH  A 501 (-2.4A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.7A)
SAH  A 501 (-4.2A)
 0.87A 5kpcA-6gkvA:
47.8		 5kpcA-6gkvA:
undetectable