SIMILAR PATTERNS OF AMINO ACIDS FOR 5KOX_A_RFPA502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhg | BETA-GLUCURONIDASE (Homo sapiens) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | VAL A 105ARG A 216PRO A 80 | None | 0.61A | 5koxA-1bhgA:0.3 | 5koxA-1bhgA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cs1 | PROTEIN(CYSTATHIONINEGAMMA-SYNTHASE) (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 3 | VAL A 154ARG A 350PRO A 149 | None | 0.84A | 5koxA-1cs1A:0.0 | 5koxA-1cs1A:25.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cz4 | VCP-LIKE ATPASE (Thermoplasmaacidophilum) |
PF02359(CDC48_N)PF02933(CDC48_2) | 3 | VAL A 120ARG A 105PRO A 176 | None | 0.73A | 5koxA-1cz4A:undetectable | 5koxA-1cz4A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ef7 | CATHEPSIN X (Homo sapiens) |
PF00112(Peptidase_C1) | 3 | VAL A 242ARG A 8PRO A 150 | None | 0.67A | 5koxA-1ef7A:0.0 | 5koxA-1ef7A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eo1 | HYPOTHETICAL PROTEINMTH1175 (Methanothermobacterthermautotrophicus) |
PF02579(Nitro_FeMo-Co) | 3 | VAL A 97ARG A 22PRO A 24 | None | 0.85A | 5koxA-1eo1A:0.0 | 5koxA-1eo1A:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ga8 | GALACTOSYLTRANSFERASE LGTC (Neisseriameningitidis) |
PF01501(Glyco_transf_8) | 3 | VAL A 133ARG A 77PRO A 248 | DEL A 500 (-4.8A)NoneNone | 0.87A | 5koxA-1ga8A:0.9 | 5koxA-1ga8A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h17 | FORMATEACETYLTRANSFERASE 1 (Escherichiacoli) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | VAL A 750ARG A 66PRO A 722 | None | 0.76A | 5koxA-1h17A:0.0 | 5koxA-1h17A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4w | MITOCHONDRIALREPLICATION PROTEINMTF1 (Saccharomycescerevisiae) |
PF00398(RrnaAD) | 3 | VAL A 28ARG A 178PRO A 241 | None | 0.74A | 5koxA-1i4wA:0.0 | 5koxA-1i4wA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3b | ATP-DEPENDENTPHOSPHOENOLPYRUVATECARBOXYKINASE (Thermusthermophilus) |
PF01293(PEPCK_ATP) | 3 | VAL A 273ARG A 130PRO A 323 | NonePO4 A2001 ( 4.0A) CA A1001 ( 4.9A) | 0.67A | 5koxA-1j3bA:0.0 | 5koxA-1j3bA:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js6 | DOPA DECARBOXYLASE (Sus scrofa) |
PF00282(Pyridoxal_deC) | 3 | VAL A 392ARG A 439PRO A 437 | None | 0.80A | 5koxA-1js6A:undetectable | 5koxA-1js6A:24.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k26 | NUDIX HOMOLOG (Pyrobaculumaerophilum) |
PF00293(NUDIX) | 3 | VAL A 128ARG A 71PRO A 56 | None | 0.85A | 5koxA-1k26A:undetectable | 5koxA-1k26A:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktc | ALPHA-N-ACETYLGALACTOSAMINIDASE (Gallus gallus) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 3 | VAL A 355ARG A 299PRO A 314 | NoneGOL A1104 (-3.4A)GOL A1101 (-4.1A) | 0.83A | 5koxA-1ktcA:undetectable | 5koxA-1ktcA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 3 | VAL A 307ARG A 126PRO A 162 | None | 0.83A | 5koxA-1lrwA:undetectable | 5koxA-1lrwA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m33 | BIOH PROTEIN (Escherichiacoli) |
PF00561(Abhydrolase_1) | 3 | VAL A 99ARG A 189PRO A 191 | None | 0.62A | 5koxA-1m33A:undetectable | 5koxA-1m33A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5t | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 3 | VAL A 189ARG A 141PRO A 332 | None | 0.73A | 5koxA-1o5tA:undetectable | 5koxA-1o5tA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 3 | VAL A 178ARG A 297PRO A 299 | None | 0.86A | 5koxA-1o5wA:12.0 | 5koxA-1o5wA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q60 | GENERALTRANSCRIPTION FACTORII-I (Mus musculus) |
PF02946(GTF2I) | 3 | VAL A 32ARG A 71PRO A 50 | None | 0.86A | 5koxA-1q60A:undetectable | 5koxA-1q60A:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5e | MULTIDRUG RESISTANCEPROTEIN MEXA (Pseudomonasaeruginosa) |
PF00529(HlyD)PF16576(HlyD_D23) | 3 | VAL A 255ARG A 39PRO A 172 | None | 0.69A | 5koxA-1t5eA:undetectable | 5koxA-1t5eA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uiy | ENOYL-COA HYDRATASE (Thermusthermophilus) |
PF00378(ECH_1) | 3 | VAL A 120ARG A 45PRO A 96 | None | 0.80A | 5koxA-1uiyA:undetectable | 5koxA-1uiyA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve5 | THREONINE DEAMINASE (Thermusthermophilus) |
PF00291(PALP) | 3 | VAL A 199ARG A 241PRO A 244 | None | 0.86A | 5koxA-1ve5A:undetectable | 5koxA-1ve5A:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1GLYCINEDEHYDROGENASESUBUNIT 2(P-PROTEIN) (Thermusthermophilus) |
PF02347(GDC-P) | 3 | VAL B 350ARG B 221PRO A 31 | None | 0.67A | 5koxA-1wytB:0.0 | 5koxA-1wytB:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zba | COAT PROTEIN VP2 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | VAL 2 43ARG 2 60PRO 2 205 | None | 0.68A | 5koxA-1zba2:undetectable | 5koxA-1zba2:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASELIKE 2 (Homo sapiens) |
PF00160(Pro_isomerase) | 3 | VAL A 401ARG A 277PRO A 437 | None | 0.78A | 5koxA-1zkcA:undetectable | 5koxA-1zkcA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3o | TYROSINE-PROTEINPHOSPHATASE,NON-RECEPTOR TYPE 6 (Homo sapiens) |
PF00017(SH2)PF00102(Y_phosphatase) | 3 | VAL A 49ARG A 7PRO A 31 | None | 0.63A | 5koxA-2b3oA:undetectable | 5koxA-2b3oA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cya | TYROSYL-TRNASYNTHETASE (Aeropyrumpernix) |
PF00579(tRNA-synt_1b) | 3 | VAL A 59ARG A 92PRO A 44 | None | 0.62A | 5koxA-2cyaA:undetectable | 5koxA-2cyaA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | VAL A 524ARG A 513PRO A 483 | None | 0.86A | 5koxA-2d1qA:undetectable | 5koxA-2d1qA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ejb | PROBABLE AROMATICACID DECARBOXYLASE (Aquifexaeolicus) |
PF02441(Flavoprotein) | 3 | VAL A 23ARG A 126PRO A 89 | None | 0.71A | 5koxA-2ejbA:undetectable | 5koxA-2ejbA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2faf | PHOSPHOENOLPYRUVATECARBOXYKINASE (Gallus gallus) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 3 | VAL A 555ARG A 458PRO A 598 | None | 0.87A | 5koxA-2fafA:undetectable | 5koxA-2fafA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwc | GLUTAMATE CYSTEINELIGASE (Brassica juncea) |
PF04107(GCS2) | 3 | VAL A 483ARG A 429PRO A 269 | None | 0.76A | 5koxA-2gwcA:1.4 | 5koxA-2gwcA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip1 | TRYPTOPHANYL-TRNASYNTHETASE (Saccharomycescerevisiae) |
PF00579(tRNA-synt_1b) | 3 | VAL A 189ARG A 141PRO A 331 | None | 0.83A | 5koxA-2ip1A:undetectable | 5koxA-2ip1A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipi | ACLACINOMYCINOXIDOREDUCTASE(AKNOX) (Streptomycesgalilaeus) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | VAL A 53ARG A 485PRO A 488 | None | 0.79A | 5koxA-2ipiA:undetectable | 5koxA-2ipiA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf4 | PERIPLASMICTREHALASE (Escherichiacoli) |
PF01204(Trehalase) | 3 | VAL A 411ARG A 268PRO A 334 | None | 0.73A | 5koxA-2jf4A:undetectable | 5koxA-2jf4A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzd | REPLICASEPOLYPROTEIN 1AB (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF11633(SUD-M) | 3 | VAL A 529ARG A 579PRO A 602 | None | 0.82A | 5koxA-2jzdA:undetectable | 5koxA-2jzdA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oaj | PROTEIN SNI1 (Saccharomycescerevisiae) |
PF08596(Lgl_C) | 3 | VAL A 649ARG A 616PRO A 627 | None | 0.83A | 5koxA-2oajA:undetectable | 5koxA-2oajA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov9 | HYPOTHETICAL PROTEIN (Rhodococcusjostii) |
PF03061(4HBT) | 3 | VAL A 102ARG A 164PRO A 167 | None | 0.84A | 5koxA-2ov9A:undetectable | 5koxA-2ov9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0b | CYTOCHROME C-TYPEPROTEIN NRFB (Escherichiacoli) |
PF09699(Paired_CXXCH_1)PF13435(Cytochrome_C554) | 3 | VAL A 81ARG A 134PRO A 103 | NoneNoneHEC A 205 (-4.5A) | 0.75A | 5koxA-2p0bA:undetectable | 5koxA-2p0bA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa5 | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 9 (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | VAL A 512ARG A 423PRO A 417 | None | 0.87A | 5koxA-2pa5A:undetectable | 5koxA-2pa5A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pe4 | HYALURONIDASE-1 (Homo sapiens) |
PF01630(Glyco_hydro_56) | 3 | VAL A 58ARG A 240PRO A 282 | None | 0.84A | 5koxA-2pe4A:undetectable | 5koxA-2pe4A:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uut | RNA-DIRECTED RNAPOLYMERASE (Sapporo virus) |
PF00680(RdRP_1) | 3 | VAL A 308ARG A 295PRO A 282 | None | 0.81A | 5koxA-2uutA:undetectable | 5koxA-2uutA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 3 | VAL A 149ARG A 85PRO A 125 | None | 0.75A | 5koxA-2v26A:undetectable | 5koxA-2v26A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vr5 | GLYCOGEN OPERONPROTEIN GLGX (Sulfolobussolfataricus) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 3 | VAL A 179ARG A 595PRO A 538 | None | 0.80A | 5koxA-2vr5A:undetectable | 5koxA-2vr5A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 3 | VAL A 388ARG A 379PRO A 355 | None | 0.86A | 5koxA-2vz9A:undetectable | 5koxA-2vz9A:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww2 | ALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 3 | VAL A 295ARG A 357PRO A 361 | None | 0.63A | 5koxA-2ww2A:undetectable | 5koxA-2ww2A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 3 | VAL A 534ARG A 78PRO A 595 | None | 0.84A | 5koxA-2x0qA:undetectable | 5koxA-2x0qA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0s | PYRUVATE PHOSPHATEDIKINASE (Trypanosomabrucei) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 3 | VAL A 883ARG A 632PRO A 568 | None | 0.86A | 5koxA-2x0sA:undetectable | 5koxA-2x0sA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjn | GLYCOSYLTRANSFERASE (Saccharopolysporaerythraea) |
PF06722(DUF1205) | 3 | VAL A 73ARG A 170PRO A 158 | None | 0.70A | 5koxA-2yjnA:undetectable | 5koxA-2yjnA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4w | ALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 3 | VAL A 377ARG A 336PRO A 391 | None | 0.87A | 5koxA-3b4wA:undetectable | 5koxA-3b4wA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efv | PUTATIVESUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Salmonellaenterica) |
PF00171(Aldedh) | 3 | VAL A 355ARG A 316PRO A 369 | None | 0.84A | 5koxA-3efvA:undetectable | 5koxA-3efvA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flo | DNA POLYMERASE ALPHASUBUNIT B (Saccharomycescerevisiae) |
PF04042(DNA_pol_E_B)PF08418(Pol_alpha_B_N) | 3 | VAL A 424ARG A 654PRO A 652 | NoneSO4 A 48 (-4.1A)None | 0.84A | 5koxA-3floA:undetectable | 5koxA-3floA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5b | NETRIN RECEPTORUNC5B (Rattusnorvegicus) |
PF00531(Death)PF00791(ZU5)PF17217(UPA) | 3 | VAL A 619ARG A 881PRO A 902 | None | 0.76A | 5koxA-3g5bA:undetectable | 5koxA-3g5bA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd7 | FUSION COMPLEX OFCYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR, RESIDUES1193-1427 ANDMALTOSE/MALTODEXTRINIMPORT ATP-BINDINGPROTEIN MALK,RESIDUES 219-371 (Escherichiacoli;Homo sapiens) |
PF00005(ABC_tran)PF08402(TOBE_2) | 3 | VAL A1293ARG A1385PRO A1372 | None | 0.75A | 5koxA-3gd7A:undetectable | 5koxA-3gd7A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gr8 | NADPH DEHYDROGENASE (Geobacilluskaustophilus) |
PF00724(Oxidored_FMN) | 3 | VAL A 63ARG A 193PRO A 119 | None | 0.84A | 5koxA-3gr8A:undetectable | 5koxA-3gr8A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hm8 | HEXOKINASE-3 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 3 | VAL A 500ARG A 730PRO A 489 | None | 0.74A | 5koxA-3hm8A:undetectable | 5koxA-3hm8A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 3 | VAL A 482ARG A 91PRO A 156 | None | 0.85A | 5koxA-3hoaA:undetectable | 5koxA-3hoaA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htz | ALANYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF01411(tRNA-synt_2c) | 3 | VAL A 438ARG A 301PRO A 393 | None | 0.85A | 5koxA-3htzA:undetectable | 5koxA-3htzA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hv0 | TRYPTOPHANYL-TRNASYNTHETASE (Cryptosporidiumparvum) |
PF00579(tRNA-synt_1b) | 3 | VAL A 308ARG A 260PRO A 449 | None | 0.60A | 5koxA-3hv0A:undetectable | 5koxA-3hv0A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i05 | TRYPTOPHANYL-TRNASYNTHETASE (Trypanosomabrucei) |
PF00579(tRNA-synt_1b) | 3 | VAL A 106ARG A 58PRO A 247 | None | 0.65A | 5koxA-3i05A:undetectable | 5koxA-3i05A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iay | DNA POLYMERASE DELTACATALYTIC SUBUNIT (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | VAL A 870ARG A 597PRO A 972 | None | 0.79A | 5koxA-3iayA:1.8 | 5koxA-3iayA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 3 | VAL A 102ARG A 88PRO A 92 | None | 0.85A | 5koxA-3kswA:undetectable | 5koxA-3kswA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2j | FUSION PROTEIN OFMALTOSE-BINDINGPERIPLASMIC PROTEINAND PARATHYROIDHORMONE/PARATHYROIDHORMONE-RELATEDPEPTIDE RECEPTOR (Escherichiacoli;Homo sapiens) |
PF02793(HRM)PF13416(SBP_bac_8) | 3 | VAL A 129ARG A 106PRO A 123 | None | 0.75A | 5koxA-3l2jA:undetectable | 5koxA-3l2jA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6x | PUTATIVEGLUTATHIONYLSPERMIDINE SYNTHASE (Methylobacillusflagellatus) |
PF14403(CP_ATPgrasp_2) | 3 | VAL A 33ARG A 76PRO A 414 | None | 0.78A | 5koxA-3n6xA:undetectable | 5koxA-3n6xA:24.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvq | SEMAPHORIN-7A (Homo sapiens) |
PF01403(Sema)PF01437(PSI)PF13895(Ig_2) | 3 | VAL A 77ARG A 167PRO A 150 | None | 0.54A | 5koxA-3nvqA:undetectable | 5koxA-3nvqA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozv | FLAVOHEMOGLOBIN (Cupriavidusnecator) |
no annotation | 3 | VAL B 90ARG B 59PRO B 398 | HEM B 404 (-4.0A)NoneHEM B 404 (-4.4A) | 0.74A | 5koxA-3ozvB:undetectable | 5koxA-3ozvB:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4x | REVERSE GYRASEHELICASE-LIKE DOMAIN (Thermotogamaritima) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | VAL A 284ARG A 263PRO A 267 | None | 0.80A | 5koxA-3p4xA:undetectable | 5koxA-3p4xA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnd | THIAMINEBIOSYNTHESISLIPOPROTEIN APBE (Salmonellaenterica) |
PF02424(ApbE) | 3 | VAL A 180ARG A 165PRO A 95 | None | 0.49A | 5koxA-3pndA:1.6 | 5koxA-3pndA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q98 | TRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | VAL A 236ARG A 122PRO A 204 | None | 0.85A | 5koxA-3q98A:undetectable | 5koxA-3q98A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qw3 | OROTIDINE-5-PHOSPHATEDECARBOXYLASE/OROTATEPHOSPHORIBOSYLTRANSFERASE, PUTATIVE(OMPDCASE-OPRTASE,PUTATIVE) (Leishmaniainfantum) |
PF00215(OMPdecase) | 3 | VAL A 80ARG A 161PRO A 112 | NoneSO4 A 259 (-2.3A)None | 0.85A | 5koxA-3qw3A:undetectable | 5koxA-3qw3A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rm5 | HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20 (Saccharomycescerevisiae) |
PF03070(TENA_THI-4)PF08543(Phos_pyr_kin) | 3 | VAL A 124ARG A 51PRO A 24 | None | 0.73A | 5koxA-3rm5A:undetectable | 5koxA-3rm5A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rsi | PUTATIVE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 3 | VAL A 124ARG A 51PRO A 100 | None | 0.83A | 5koxA-3rsiA:undetectable | 5koxA-3rsiA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t5t | PUTATIVEGLYCOSYLTRANSFERASE (Streptomyceshygroscopicus) |
PF00982(Glyco_transf_20) | 3 | VAL A 38ARG A 218PRO A 184 | None | 0.70A | 5koxA-3t5tA:undetectable | 5koxA-3t5tA:26.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u5z | DNA POLYMERASEPROCESSIVITYCOMPONENT (Escherichiavirus T4) |
no annotation | 3 | VAL G5218ARG G5128PRO G5191 | None | 0.77A | 5koxA-3u5zG:undetectable | 5koxA-3u5zG:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upn | PENICILLIN-BINDINGPROTEIN A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 3 | VAL A 454ARG A 212PRO A 346 | None | 0.86A | 5koxA-3upnA:undetectable | 5koxA-3upnA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsz | RICIN B LECTIN (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43)PF14200(RicinB_lectin_2) | 3 | VAL A 183ARG A 84PRO A 150 | None | 0.66A | 5koxA-3vszA:undetectable | 5koxA-3vszA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsz | RICIN B LECTIN (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43)PF14200(RicinB_lectin_2) | 3 | VAL A 185ARG A 84PRO A 150 | None | 0.74A | 5koxA-3vszA:undetectable | 5koxA-3vszA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w2z | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN (Nostoc sp. PCC7120) |
PF01590(GAF) | 3 | VAL A 23ARG A 102PRO A 139 | NoneCYC A 201 (-3.7A)None | 0.86A | 5koxA-3w2zA:undetectable | 5koxA-3w2zA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 3 | VAL A 340ARG A 468PRO A 36 | None | 0.81A | 5koxA-3w9hA:2.5 | 5koxA-3w9hA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wa5 | TSE3-SPECIFICIMMUNITY PROTEIN (Pseudomonasaeruginosa) |
no annotation | 3 | VAL B 36ARG B 89PRO B 111 | None | 0.86A | 5koxA-3wa5B:undetectable | 5koxA-3wa5B:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | VAL A 905ARG A 917PRO A 922 | NoneMTE A3003 ( 2.9A)None | 0.83A | 5koxA-3zyvA:undetectable | 5koxA-3zyvA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7k | ALDOS-2-ULOSEDEHYDRATASE (Phanerochaetechrysosporium) |
no annotation | 3 | VAL A 429ARG A 43PRO A 41 | NoneNoneGOL A1900 (-4.3A) | 0.84A | 5koxA-4a7kA:undetectable | 5koxA-4a7kA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 3 | VAL A 149ARG A 85PRO A 125 | None | 0.85A | 5koxA-4anjA:undetectable | 5koxA-4anjA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 3 | VAL A 566ARG A 724PRO A 731 | NAG B3452 (-3.8A)NoneNone | 0.83A | 5koxA-4cakA:0.7 | 5koxA-4cakA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eys | MCCC FAMILY PROTEIN (Streptococcuspneumoniae) |
PF02016(Peptidase_S66) | 3 | VAL A 99ARG A 85PRO A 88 | None | 0.85A | 5koxA-4eysA:undetectable | 5koxA-4eysA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0q | RESTRICTIONENDONUCLEASE (Mycobacteriumsp. JLS) |
PF04471(Mrr_cat) | 3 | VAL A 365ARG A 419PRO A 276 | None | 0.79A | 5koxA-4f0qA:undetectable | 5koxA-4f0qA:25.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3e | CASA (Thermusthermophilus) |
PF09481(CRISPR_Cse1) | 3 | VAL A 174ARG A 239PRO A 244 | None | 0.79A | 5koxA-4f3eA:undetectable | 5koxA-4f3eA:25.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gh4 | CAPSID PROTEIN VP2 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | VAL B 43ARG B 60PRO B 205 | None | 0.79A | 5koxA-4gh4B:undetectable | 5koxA-4gh4B:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hao | PROBABLE INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Yersinia pestis) |
PF01513(NAD_kinase) | 3 | VAL A 116ARG A 95PRO A 106 | NoneNoneACY A 402 (-4.9A) | 0.81A | 5koxA-4haoA:undetectable | 5koxA-4haoA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjc | ENVELOPEGLYCOPROTEIN (Rift Valleyfeverphlebovirus) |
PF07245(Phlebovirus_G2) | 3 | VAL A 916ARG A 949PRO A 924 | None | 0.49A | 5koxA-4hjcA:undetectable | 5koxA-4hjcA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | VAL A 546ARG A 604PRO A 553 | None | 0.85A | 5koxA-4iigA:undetectable | 5koxA-4iigA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ij5 | PHOSPHOSERINEPHOSPHATASE 1 (Hydrogenobacterthermophilus) |
PF00300(His_Phos_1) | 3 | VAL A 136ARG A 8PRO A 153 | None CL A 301 (-4.2A)None | 0.74A | 5koxA-4ij5A:undetectable | 5koxA-4ij5A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4isa | UDP-3-O-[3-HYDROXYMYRISTOYL]N-ACETYLGLUCOSAMINEDEACETYLASE (Escherichiacoli) |
PF03331(LpxC) | 3 | VAL A 96ARG A 190PRO A 110 | NoneNoneFMT A 410 (-4.2A) | 0.75A | 5koxA-4isaA:undetectable | 5koxA-4isaA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhz | BETA-GLUCURONIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | VAL A 73ARG A 172PRO A 48 | None | 0.81A | 5koxA-4jhzA:undetectable | 5koxA-4jhzA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldp | NDP-FOROSAMYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 3 | VAL A 53ARG A 149PRO A 137 | None | 0.67A | 5koxA-4ldpA:undetectable | 5koxA-4ldpA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfy | DIHYDROOROTASE (Burkholderiacenocepacia) |
PF01979(Amidohydro_1) | 3 | VAL A 188ARG A 167PRO A 120 | None | 0.80A | 5koxA-4lfyA:undetectable | 5koxA-4lfyA:25.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n88 | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
no annotation | 3 | VAL B 36ARG B 89PRO B 111 | None | 0.80A | 5koxA-4n88B:undetectable | 5koxA-4n88B:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfu | SENESCENCE-ASSOCIATED CARBOXYLESTERASE101 (Arabidopsisthaliana) |
PF01764(Lipase_3) | 3 | VAL B 16ARG B 194PRO B 170 | None | 0.80A | 5koxA-4nfuB:undetectable | 5koxA-4nfuB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntd | THIOREDOXINREDUCTASE (Streptomycesclavuligerus) |
PF07992(Pyr_redox_2) | 3 | VAL A 205ARG A 170PRO A 199 | None | 0.79A | 5koxA-4ntdA:8.6 | 5koxA-4ntdA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oaq | R-SPECIFIC CARBONYLREDUCTASE (Candidaparapsilosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | VAL A 281ARG A 328PRO A 164 | NDP A 401 (-3.9A)NoneNone | 0.85A | 5koxA-4oaqA:undetectable | 5koxA-4oaqA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oer | NIKA PROTEIN (Brucella suis) |
PF00496(SBP_bac_5) | 3 | VAL A 461ARG A 445PRO A 402 | NoneGOL A 606 ( 4.4A)None | 0.85A | 5koxA-4oerA:1.3 | 5koxA-4oerA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou4 | ALPHA/BETA HYDROLASEFOLD-3 DOMAINPROTEIN (Pseudomonas sp.ECU1011) |
PF07859(Abhydrolase_3) | 3 | VAL A 139ARG A 102PRO A 71 | None | 0.76A | 5koxA-4ou4A:undetectable | 5koxA-4ou4A:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p3i | P DOMAIN OF VP1 (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 3 | VAL A 395ARG A 290PRO A 248 | None | 0.85A | 5koxA-4p3iA:undetectable | 5koxA-4p3iA:21.99 |