SIMILAR PATTERNS OF AMINO ACIDS FOR 5KOX_A_RFPA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 VAL A 105
ARG A 216
PRO A  80
None
0.61A 5koxA-1bhgA:
0.3
5koxA-1bhgA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)


(Escherichia
coli)
PF01053
(Cys_Met_Meta_PP)
3 VAL A 154
ARG A 350
PRO A 149
None
0.84A 5koxA-1cs1A:
0.0
5koxA-1cs1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz4 VCP-LIKE ATPASE

(Thermoplasma
acidophilum)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
3 VAL A 120
ARG A 105
PRO A 176
None
0.73A 5koxA-1cz4A:
undetectable
5koxA-1cz4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef7 CATHEPSIN X

(Homo sapiens)
PF00112
(Peptidase_C1)
3 VAL A 242
ARG A   8
PRO A 150
None
0.67A 5koxA-1ef7A:
0.0
5koxA-1ef7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo1 HYPOTHETICAL PROTEIN
MTH1175


(Methanothermobacter
thermautotrophicus)
PF02579
(Nitro_FeMo-Co)
3 VAL A  97
ARG A  22
PRO A  24
None
0.85A 5koxA-1eo1A:
0.0
5koxA-1eo1A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC


(Neisseria
meningitidis)
PF01501
(Glyco_transf_8)
3 VAL A 133
ARG A  77
PRO A 248
DEL  A 500 (-4.8A)
None
None
0.87A 5koxA-1ga8A:
0.9
5koxA-1ga8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1


(Escherichia
coli)
PF01228
(Gly_radical)
PF02901
(PFL-like)
3 VAL A 750
ARG A  66
PRO A 722
None
0.76A 5koxA-1h17A:
0.0
5koxA-1h17A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1


(Saccharomyces
cerevisiae)
PF00398
(RrnaAD)
3 VAL A  28
ARG A 178
PRO A 241
None
0.74A 5koxA-1i4wA:
0.0
5koxA-1i4wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Thermus
thermophilus)
PF01293
(PEPCK_ATP)
3 VAL A 273
ARG A 130
PRO A 323
None
PO4  A2001 ( 4.0A)
CA  A1001 ( 4.9A)
0.67A 5koxA-1j3bA:
0.0
5koxA-1j3bA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa)
PF00282
(Pyridoxal_deC)
3 VAL A 392
ARG A 439
PRO A 437
None
0.80A 5koxA-1js6A:
undetectable
5koxA-1js6A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum)
PF00293
(NUDIX)
3 VAL A 128
ARG A  71
PRO A  56
None
0.85A 5koxA-1k26A:
undetectable
5koxA-1k26A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Gallus gallus)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
3 VAL A 355
ARG A 299
PRO A 314
None
GOL  A1104 (-3.4A)
GOL  A1101 (-4.1A)
0.83A 5koxA-1ktcA:
undetectable
5koxA-1ktcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1


(Paracoccus
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
3 VAL A 307
ARG A 126
PRO A 162
None
0.83A 5koxA-1lrwA:
undetectable
5koxA-1lrwA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli)
PF00561
(Abhydrolase_1)
3 VAL A  99
ARG A 189
PRO A 191
None
0.62A 5koxA-1m33A:
undetectable
5koxA-1m33A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
3 VAL A 189
ARG A 141
PRO A 332
None
0.73A 5koxA-1o5tA:
undetectable
5koxA-1o5tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Rattus
norvegicus)
PF01593
(Amino_oxidase)
3 VAL A 178
ARG A 297
PRO A 299
None
0.86A 5koxA-1o5wA:
12.0
5koxA-1o5wA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q60 GENERAL
TRANSCRIPTION FACTOR
II-I


(Mus musculus)
PF02946
(GTF2I)
3 VAL A  32
ARG A  71
PRO A  50
None
0.86A 5koxA-1q60A:
undetectable
5koxA-1q60A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA


(Pseudomonas
aeruginosa)
PF00529
(HlyD)
PF16576
(HlyD_D23)
3 VAL A 255
ARG A  39
PRO A 172
None
0.69A 5koxA-1t5eA:
undetectable
5koxA-1t5eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus)
PF00378
(ECH_1)
3 VAL A 120
ARG A  45
PRO A  96
None
0.80A 5koxA-1uiyA:
undetectable
5koxA-1uiyA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus)
PF00291
(PALP)
3 VAL A 199
ARG A 241
PRO A 244
None
0.86A 5koxA-1ve5A:
undetectable
5koxA-1ve5A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
3 VAL B 350
ARG B 221
PRO A  31
None
0.67A 5koxA-1wytB:
0.0
5koxA-1wytB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zba COAT PROTEIN VP2

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 VAL 2  43
ARG 2  60
PRO 2 205
None
0.68A 5koxA-1zba2:
undetectable
5koxA-1zba2:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2


(Homo sapiens)
PF00160
(Pro_isomerase)
3 VAL A 401
ARG A 277
PRO A 437
None
0.78A 5koxA-1zkcA:
undetectable
5koxA-1zkcA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
3 VAL A  49
ARG A   7
PRO A  31
None
0.63A 5koxA-2b3oA:
undetectable
5koxA-2b3oA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE


(Aeropyrum
pernix)
PF00579
(tRNA-synt_1b)
3 VAL A  59
ARG A  92
PRO A  44
None
0.62A 5koxA-2cyaA:
undetectable
5koxA-2cyaA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE


(Luciola
cruciata)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 VAL A 524
ARG A 513
PRO A 483
None
0.86A 5koxA-2d1qA:
undetectable
5koxA-2d1qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE


(Aquifex
aeolicus)
PF02441
(Flavoprotein)
3 VAL A  23
ARG A 126
PRO A  89
None
0.71A 5koxA-2ejbA:
undetectable
5koxA-2ejbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Gallus gallus)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
3 VAL A 555
ARG A 458
PRO A 598
None
0.87A 5koxA-2fafA:
undetectable
5koxA-2fafA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE


(Brassica juncea)
PF04107
(GCS2)
3 VAL A 483
ARG A 429
PRO A 269
None
0.76A 5koxA-2gwcA:
1.4
5koxA-2gwcA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE


(Saccharomyces
cerevisiae)
PF00579
(tRNA-synt_1b)
3 VAL A 189
ARG A 141
PRO A 331
None
0.83A 5koxA-2ip1A:
undetectable
5koxA-2ip1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)


(Streptomyces
galilaeus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 VAL A  53
ARG A 485
PRO A 488
None
0.79A 5koxA-2ipiA:
undetectable
5koxA-2ipiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE


(Escherichia
coli)
PF01204
(Trehalase)
3 VAL A 411
ARG A 268
PRO A 334
None
0.73A 5koxA-2jf4A:
undetectable
5koxA-2jf4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzd REPLICASE
POLYPROTEIN 1AB


(Severe acute
respiratory
syndrome-related
coronavirus)
PF11633
(SUD-M)
3 VAL A 529
ARG A 579
PRO A 602
None
0.82A 5koxA-2jzdA:
undetectable
5koxA-2jzdA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae)
PF08596
(Lgl_C)
3 VAL A 649
ARG A 616
PRO A 627
None
0.83A 5koxA-2oajA:
undetectable
5koxA-2oajA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii)
PF03061
(4HBT)
3 VAL A 102
ARG A 164
PRO A 167
None
0.84A 5koxA-2ov9A:
undetectable
5koxA-2ov9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0b CYTOCHROME C-TYPE
PROTEIN NRFB


(Escherichia
coli)
PF09699
(Paired_CXXCH_1)
PF13435
(Cytochrome_C554)
3 VAL A  81
ARG A 134
PRO A 103
None
None
HEC  A 205 (-4.5A)
0.75A 5koxA-2p0bA:
undetectable
5koxA-2p0bA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9


(Homo sapiens)
PF00102
(Y_phosphatase)
3 VAL A 512
ARG A 423
PRO A 417
None
0.87A 5koxA-2pa5A:
undetectable
5koxA-2pa5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens)
PF01630
(Glyco_hydro_56)
3 VAL A  58
ARG A 240
PRO A 282
None
0.84A 5koxA-2pe4A:
undetectable
5koxA-2pe4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE


(Sapporo virus)
PF00680
(RdRP_1)
3 VAL A 308
ARG A 295
PRO A 282
None
0.81A 5koxA-2uutA:
undetectable
5koxA-2uutA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa)
PF00063
(Myosin_head)
3 VAL A 149
ARG A  85
PRO A 125
None
0.75A 5koxA-2v26A:
undetectable
5koxA-2v26A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX


(Sulfolobus
solfataricus)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
3 VAL A 179
ARG A 595
PRO A 538
None
0.80A 5koxA-2vr5A:
undetectable
5koxA-2vr5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
3 VAL A 388
ARG A 379
PRO A 355
None
0.86A 5koxA-2vz9A:
undetectable
5koxA-2vz9A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
3 VAL A 295
ARG A 357
PRO A 361
None
0.63A 5koxA-2ww2A:
undetectable
5koxA-2ww2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
3 VAL A 534
ARG A  78
PRO A 595
None
0.84A 5koxA-2x0qA:
undetectable
5koxA-2x0qA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE


(Trypanosoma
brucei)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
3 VAL A 883
ARG A 632
PRO A 568
None
0.86A 5koxA-2x0sA:
undetectable
5koxA-2x0sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea)
PF06722
(DUF1205)
3 VAL A  73
ARG A 170
PRO A 158
None
0.70A 5koxA-2yjnA:
undetectable
5koxA-2yjnA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
3 VAL A 377
ARG A 336
PRO A 391
None
0.87A 5koxA-3b4wA:
undetectable
5koxA-3b4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE


(Salmonella
enterica)
PF00171
(Aldedh)
3 VAL A 355
ARG A 316
PRO A 369
None
0.84A 5koxA-3efvA:
undetectable
5koxA-3efvA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B


(Saccharomyces
cerevisiae)
PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
3 VAL A 424
ARG A 654
PRO A 652
None
SO4  A  48 (-4.1A)
None
0.84A 5koxA-3floA:
undetectable
5koxA-3floA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5b NETRIN RECEPTOR
UNC5B


(Rattus
norvegicus)
PF00531
(Death)
PF00791
(ZU5)
PF17217
(UPA)
3 VAL A 619
ARG A 881
PRO A 902
None
0.76A 5koxA-3g5bA:
undetectable
5koxA-3g5bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371


(Escherichia
coli;
Homo sapiens)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
3 VAL A1293
ARG A1385
PRO A1372
None
0.75A 5koxA-3gd7A:
undetectable
5koxA-3gd7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus)
PF00724
(Oxidored_FMN)
3 VAL A  63
ARG A 193
PRO A 119
None
0.84A 5koxA-3gr8A:
undetectable
5koxA-3gr8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
3 VAL A 500
ARG A 730
PRO A 489
None
0.74A 5koxA-3hm8A:
undetectable
5koxA-3hm8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1


(Thermus
thermophilus)
PF02074
(Peptidase_M32)
3 VAL A 482
ARG A  91
PRO A 156
None
0.85A 5koxA-3hoaA:
undetectable
5koxA-3hoaA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE


(Aquifex
aeolicus)
PF01411
(tRNA-synt_2c)
3 VAL A 438
ARG A 301
PRO A 393
None
0.85A 5koxA-3htzA:
undetectable
5koxA-3htzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE


(Cryptosporidium
parvum)
PF00579
(tRNA-synt_1b)
3 VAL A 308
ARG A 260
PRO A 449
None
0.60A 5koxA-3hv0A:
undetectable
5koxA-3hv0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE


(Trypanosoma
brucei)
PF00579
(tRNA-synt_1b)
3 VAL A 106
ARG A  58
PRO A 247
None
0.65A 5koxA-3i05A:
undetectable
5koxA-3i05A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
3 VAL A 870
ARG A 597
PRO A 972
None
0.79A 5koxA-3iayA:
1.8
5koxA-3iayA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE


(Trypanosoma
cruzi)
PF00067
(p450)
3 VAL A 102
ARG A  88
PRO A  92
None
0.85A 5koxA-3kswA:
undetectable
5koxA-3kswA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR


(Escherichia
coli;
Homo sapiens)
PF02793
(HRM)
PF13416
(SBP_bac_8)
3 VAL A 129
ARG A 106
PRO A 123
None
0.75A 5koxA-3l2jA:
undetectable
5koxA-3l2jA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE


(Methylobacillus
flagellatus)
PF14403
(CP_ATPgrasp_2)
3 VAL A  33
ARG A  76
PRO A 414
None
0.78A 5koxA-3n6xA:
undetectable
5koxA-3n6xA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2)
3 VAL A  77
ARG A 167
PRO A 150
None
0.54A 5koxA-3nvqA:
undetectable
5koxA-3nvqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator)
no annotation 3 VAL B  90
ARG B  59
PRO B 398
HEM  B 404 (-4.0A)
None
HEM  B 404 (-4.4A)
0.74A 5koxA-3ozvB:
undetectable
5koxA-3ozvB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN


(Thermotoga
maritima)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 VAL A 284
ARG A 263
PRO A 267
None
0.80A 5koxA-3p4xA:
undetectable
5koxA-3p4xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE


(Salmonella
enterica)
PF02424
(ApbE)
3 VAL A 180
ARG A 165
PRO A  95
None
0.49A 5koxA-3pndA:
1.6
5koxA-3pndA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 VAL A 236
ARG A 122
PRO A 204
None
0.85A 5koxA-3q98A:
undetectable
5koxA-3q98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)


(Leishmania
infantum)
PF00215
(OMPdecase)
3 VAL A  80
ARG A 161
PRO A 112
None
SO4  A 259 (-2.3A)
None
0.85A 5koxA-3qw3A:
undetectable
5koxA-3qw3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20


(Saccharomyces
cerevisiae)
PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin)
3 VAL A 124
ARG A  51
PRO A  24
None
0.73A 5koxA-3rm5A:
undetectable
5koxA-3rm5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsi PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
3 VAL A 124
ARG A  51
PRO A 100
None
0.83A 5koxA-3rsiA:
undetectable
5koxA-3rsiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE


(Streptomyces
hygroscopicus)
PF00982
(Glyco_transf_20)
3 VAL A  38
ARG A 218
PRO A 184
None
0.70A 5koxA-3t5tA:
undetectable
5koxA-3t5tA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5z DNA POLYMERASE
PROCESSIVITY
COMPONENT


(Escherichia
virus T4)
no annotation 3 VAL G5218
ARG G5128
PRO G5191
None
0.77A 5koxA-3u5zG:
undetectable
5koxA-3u5zG:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
3 VAL A 454
ARG A 212
PRO A 346
None
0.86A 5koxA-3upnA:
undetectable
5koxA-3upnA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum)
PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2)
3 VAL A 183
ARG A  84
PRO A 150
None
0.66A 5koxA-3vszA:
undetectable
5koxA-3vszA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum)
PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2)
3 VAL A 185
ARG A  84
PRO A 150
None
0.74A 5koxA-3vszA:
undetectable
5koxA-3vszA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN


(Nostoc sp. PCC
7120)
PF01590
(GAF)
3 VAL A  23
ARG A 102
PRO A 139
None
CYC  A 201 (-3.7A)
None
0.86A 5koxA-3w2zA:
undetectable
5koxA-3w2zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B


(Escherichia
coli)
PF00873
(ACR_tran)
3 VAL A 340
ARG A 468
PRO A  36
None
0.81A 5koxA-3w9hA:
2.5
5koxA-3w9hA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa5 TSE3-SPECIFIC
IMMUNITY PROTEIN


(Pseudomonas
aeruginosa)
no annotation 3 VAL B  36
ARG B  89
PRO B 111
None
0.86A 5koxA-3wa5B:
undetectable
5koxA-3wa5B:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 VAL A 905
ARG A 917
PRO A 922
None
MTE  A3003 ( 2.9A)
None
0.83A 5koxA-3zyvA:
undetectable
5koxA-3zyvA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE


(Phanerochaete
chrysosporium)
no annotation 3 VAL A 429
ARG A  43
PRO A  41
None
None
GOL  A1900 (-4.3A)
0.84A 5koxA-4a7kA:
undetectable
5koxA-4a7kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Sus scrofa)
PF00063
(Myosin_head)
PF01353
(GFP)
3 VAL A 149
ARG A  85
PRO A 125
None
0.85A 5koxA-4anjA:
undetectable
5koxA-4anjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
3 VAL A 566
ARG A 724
PRO A 731
NAG  B3452 (-3.8A)
None
None
0.83A 5koxA-4cakA:
0.7
5koxA-4cakA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae)
PF02016
(Peptidase_S66)
3 VAL A  99
ARG A  85
PRO A  88
None
0.85A 5koxA-4eysA:
undetectable
5koxA-4eysA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE


(Mycobacterium
sp. JLS)
PF04471
(Mrr_cat)
3 VAL A 365
ARG A 419
PRO A 276
None
0.79A 5koxA-4f0qA:
undetectable
5koxA-4f0qA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus)
PF09481
(CRISPR_Cse1)
3 VAL A 174
ARG A 239
PRO A 244
None
0.79A 5koxA-4f3eA:
undetectable
5koxA-4f3eA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 VAL B  43
ARG B  60
PRO B 205
None
0.79A 5koxA-4gh4B:
undetectable
5koxA-4gh4B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Yersinia pestis)
PF01513
(NAD_kinase)
3 VAL A 116
ARG A  95
PRO A 106
None
None
ACY  A 402 (-4.9A)
0.81A 5koxA-4haoA:
undetectable
5koxA-4haoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN


(Rift Valley
fever
phlebovirus)
PF07245
(Phlebovirus_G2)
3 VAL A 916
ARG A 949
PRO A 924
None
0.49A 5koxA-4hjcA:
undetectable
5koxA-4hjcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 VAL A 546
ARG A 604
PRO A 553
None
0.85A 5koxA-4iigA:
undetectable
5koxA-4iigA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij5 PHOSPHOSERINE
PHOSPHATASE 1


(Hydrogenobacter
thermophilus)
PF00300
(His_Phos_1)
3 VAL A 136
ARG A   8
PRO A 153
None
CL  A 301 (-4.2A)
None
0.74A 5koxA-4ij5A:
undetectable
5koxA-4ij5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Escherichia
coli)
PF03331
(LpxC)
3 VAL A  96
ARG A 190
PRO A 110
None
None
FMT  A 410 (-4.2A)
0.75A 5koxA-4isaA:
undetectable
5koxA-4isaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 VAL A  73
ARG A 172
PRO A  48
None
0.81A 5koxA-4jhzA:
undetectable
5koxA-4jhzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
3 VAL A  53
ARG A 149
PRO A 137
None
0.67A 5koxA-4ldpA:
undetectable
5koxA-4ldpA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia)
PF01979
(Amidohydro_1)
3 VAL A 188
ARG A 167
PRO A 120
None
0.80A 5koxA-4lfyA:
undetectable
5koxA-4lfyA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n88 UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 3 VAL B  36
ARG B  89
PRO B 111
None
0.80A 5koxA-4n88B:
undetectable
5koxA-4n88B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101


(Arabidopsis
thaliana)
PF01764
(Lipase_3)
3 VAL B  16
ARG B 194
PRO B 170
None
0.80A 5koxA-4nfuB:
undetectable
5koxA-4nfuB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE


(Streptomyces
clavuligerus)
PF07992
(Pyr_redox_2)
3 VAL A 205
ARG A 170
PRO A 199
None
0.79A 5koxA-4ntdA:
8.6
5koxA-4ntdA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE


(Candida
parapsilosis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 VAL A 281
ARG A 328
PRO A 164
NDP  A 401 (-3.9A)
None
None
0.85A 5koxA-4oaqA:
undetectable
5koxA-4oaqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis)
PF00496
(SBP_bac_5)
3 VAL A 461
ARG A 445
PRO A 402
None
GOL  A 606 ( 4.4A)
None
0.85A 5koxA-4oerA:
1.3
5koxA-4oerA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN


(Pseudomonas sp.
ECU1011)
PF07859
(Abhydrolase_3)
3 VAL A 139
ARG A 102
PRO A  71
None
0.76A 5koxA-4ou4A:
undetectable
5koxA-4ou4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
3 VAL A 395
ARG A 290
PRO A 248
None
0.85A 5koxA-4p3iA:
undetectable
5koxA-4p3iA:
21.99