SIMILAR PATTERNS OF AMINO ACIDS FOR 5KOC_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1k SCAFFOLDING PROTEIN

([Clostridium]
cellulolyticum) 		PF00963
(Cohesin) 		5 GLY A  42
VAL A 139
THR A 140
ALA A  45
LEU A  48
 None
 1.01A 5kocA-1g1kA:
undetectable		 5kocA-1g1kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		6 GLY A 125
ASN A 101
VAL A 104
VAL A 131
ALA A 132
LEU A 130
 None
 1.33A 5kocA-1hnoA:
undetectable		 5kocA-1hnoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 PHE A 237
GLY A 238
VAL A 126
ALA A 218
LEU A 221
 None
 1.11A 5kocA-1idmA:
undetectable		 5kocA-1idmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A  11
ASP A  46
VAL A  47
THR A  48
LEU A  72
 None
 1.08A 5kocA-1iovA:
undetectable		 5kocA-1iovA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		5 GLY H   5
VAL H 137
VAL H 152
ALA H 151
LEU H 154
 None
 0.91A 5kocA-1j2qH:
undetectable		 5kocA-1j2qH:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 GLY A 646
VAL A 681
VAL A 651
ALA A 652
LEU A 653
 None
 1.11A 5kocA-1jj7A:
undetectable		 5kocA-1jj7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 344
ASP A 108
VAL A 277
THR A 278
LEU A 127
 None
 0.89A 5kocA-1mnsA:
undetectable		 5kocA-1mnsA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyo IMMUNOGENIC PROTEIN
MPT70

(Mycobacterium
tuberculosis) 		PF02469
(Fasciclin) 		5 GLY A 143
VAL A 126
THR A 125
VAL A  68
ALA A  70
 None
 1.08A 5kocA-1nyoA:
undetectable		 5kocA-1nyoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		5 GLY A 432
VAL A 418
THR A 416
ALA A 450
LEU A 454
 FNS  A 570 (-3.4A)
None
None
None
None
 0.96A 5kocA-1qcwA:
undetectable		 5kocA-1qcwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbu PEROXISOMAL
ACYL-COENZYME A
THIOESTER HYDROLASE
1

(Saccharomyces
cerevisiae) 		PF13622
(4HBT_3) 		5 GLY A  90
ASN A  86
THR A  56
VAL A 116
ALA A 115
 None
 1.06A 5kocA-1tbuA:
undetectable		 5kocA-1tbuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		5 GLY A  27
VAL A  53
VAL A  38
ALA A  37
LEU A  41
 None
 1.05A 5kocA-1uj4A:
3.1		 5kocA-1uj4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 200
ASN A 128
VAL A 133
THR A 508
VAL A 154
 None
 1.10A 5kocA-1w18A:
undetectable		 5kocA-1w18A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3s RAS-RELATED PROTEIN
RAB-18

(Homo sapiens) 		PF00071
(Ras) 		5 GLY A 157
ASN A 122
ASP A  89
VAL A  90
THR A  91
 None
GNP  A 300 (-3.2A)
None
None
None
 0.84A 5kocA-1x3sA:
undetectable		 5kocA-1x3sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		5 PHE A2337
GLY A2339
VAL A2467
VAL A2313
ALA A2314
 None
 0.95A 5kocA-1xktA:
undetectable		 5kocA-1xktA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 GLY A 349
ASP A 594
THR A 596
ALA A 355
LEU A 356
 None
 1.02A 5kocA-1yq2A:
undetectable		 5kocA-1yq2A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 GLY A 144
ASP A 154
VAL A 155
THR A 156
LEU A 125
 None
NAG  A1731 ( 4.1A)
None
NAG  A1730 ( 4.3A)
None
 0.73A 5kocA-2c11A:
undetectable		 5kocA-2c11A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 SER A 138
ASP A 159
VAL A 158
ALA A 145
LEU A 146
 None
 1.02A 5kocA-2cyaA:
undetectable		 5kocA-2cyaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		5 GLY A 149
VAL A  72
VAL A  94
ALA A 143
LEU A 142
 None
 0.83A 5kocA-2ea3A:
undetectable		 5kocA-2ea3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		6 GLY A  65
ASN A  34
VAL A  37
THR A  38
ALA A 115
LEU A 114
 None
 1.46A 5kocA-2ej5A:
undetectable		 5kocA-2ej5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 GLY A 192
VAL A 226
THR A 227
ALA A 240
LEU A 239
 None
 0.97A 5kocA-2gzsA:
undetectable		 5kocA-2gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		5 GLY A 623
VAL A 658
VAL A 628
ALA A 629
LEU A 630
 None
 0.98A 5kocA-2ixfA:
undetectable		 5kocA-2ixfA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 GLY A 179
VAL A  12
VAL A 115
ALA A 169
LEU A 168
 None
 0.85A 5kocA-2j92A:
undetectable		 5kocA-2j92A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 GLY A  37
SER A  40
VAL A   8
ALA A 142
LEU A   7
 None
 1.03A 5kocA-2k8iA:
undetectable		 5kocA-2k8iA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		5 PHE A  88
GLY A  80
VAL A 110
VAL A  60
LEU A  58
 None
 1.09A 5kocA-2kfuA:
undetectable		 5kocA-2kfuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 SER A  68
ASN A  11
VAL A  14
VAL A 127
LEU A 125
 None
 0.84A 5kocA-2l6fA:
undetectable		 5kocA-2l6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6h FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03623
(Focal_AT) 		5 SER A  68
ASN A  11
VAL A  14
VAL A 127
LEU A 125
 None
 1.04A 5kocA-2l6hA:
undetectable		 5kocA-2l6hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1b GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		5 ASN A 122
ASP A  91
VAL A  92
THR A  93
ALA A 194
 None
 0.86A 5kocA-2n1bA:
undetectable		 5kocA-2n1bA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		5 SER A 148
VAL A 224
VAL A 243
ALA A 185
LEU A 186
 None
 1.11A 5kocA-2pd3A:
4.4		 5kocA-2pd3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 GLY A 143
ASP A 153
VAL A 154
THR A 155
LEU A 124
 None
 0.76A 5kocA-2pncA:
undetectable		 5kocA-2pncA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		5 GLY A 492
GLN A 495
ASP A 511
VAL A 512
THR A 513
 None
 0.90A 5kocA-2ralA:
undetectable		 5kocA-2ralA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 486
ASN A 572
VAL A 574
VAL A 532
ALA A 533
 None
 1.07A 5kocA-2waeA:
undetectable		 5kocA-2waeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A  58
VAL A 281
VAL A  63
ALA A  64
LEU A  65
 None
 1.09A 5kocA-2z1aA:
undetectable		 5kocA-2z1aA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		5 THR A 114
VAL A  45
ALA A   4
LEU A   3
HIS A 240
 None
 1.02A 5kocA-2zoaA:
undetectable		 5kocA-2zoaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		5 GLY A   5
ASP A  69
VAL A  93
ALA A  87
LEU A  86
 None
 1.06A 5kocA-3aufA:
2.8		 5kocA-3aufA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		5 GLY A 162
SER A  44
VAL A 231
VAL A 216
LEU A 255
 None
 1.00A 5kocA-3ch7A:
undetectable		 5kocA-3ch7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpq 50S RIBOSOMAL
PROTEIN L30E

(Methanocaldococcus
jannaschii) 		PF01248
(Ribosomal_L7Ae) 		5 GLY A  25
ASP A  54
VAL A  55
ALA A  44
LEU A  43
 None
 1.02A 5kocA-3cpqA:
undetectable		 5kocA-3cpqA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 137
VAL A  98
VAL A 204
ALA A 207
LEU A 208
 None
 1.04A 5kocA-3dt8A:
undetectable		 5kocA-3dt8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e98 GAF DOMAIN OF
UNKNOWN FUNCTION

(Pseudomonas
aeruginosa) 		PF04340
(DUF484) 		5 GLY A 212
VAL A 106
THR A 105
ALA A 219
LEU A 218
 EDO  A 234 ( 4.8A)
None
None
EDO  A 234 (-3.4A)
None
 1.00A 5kocA-3e98A:
undetectable		 5kocA-3e98A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 379
ASP A 131
VAL A 300
THR A 301
LEU A 150
 None
 1.02A 5kocA-3ekgA:
undetectable		 5kocA-3ekgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 GLN A 124
THR A 114
VAL A  81
ALA A 104
LEU A 105
 GOL  A 361 (-2.9A)
None
None
None
None
 1.10A 5kocA-3f0hA:
2.9		 5kocA-3f0hA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Methylobacillus
flagellatus) 		PF13460
(NAD_binding_10) 		5 GLY A  29
ASP A  47
VAL A  48
THR A  49
VAL A  66
 None
 1.07A 5kocA-3gpiA:
undetectable		 5kocA-3gpiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		5 PHE A 311
GLY A 314
VAL A 322
VAL A 265
ALA A 266
 None
 1.05A 5kocA-3hd6A:
undetectable		 5kocA-3hd6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A  53
ASP A 409
VAL A 443
VAL A  77
LEU A  31
 None
 1.06A 5kocA-3hpaA:
undetectable		 5kocA-3hpaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 305
VAL A 270
VAL A 254
ALA A 253
LEU A 257
 None
 1.06A 5kocA-3i58A:
11.6		 5kocA-3i58A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 5 ASP A  27
VAL A  28
THR A  29
ALA A 111
LEU A 112
 None
 1.05A 5kocA-3ihmA:
undetectable		 5kocA-3ihmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 5 ASP A 288
VAL A 289
VAL A 263
ALA A 262
LEU A 265
 None
 1.10A 5kocA-3j3iA:
undetectable		 5kocA-3j3iA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 GLY A 543
VAL A 517
THR A 515
ALA A 551
LEU A 552
 None
 1.04A 5kocA-3j97A:
2.2		 5kocA-3j97A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 GLY A  40
SER A  44
VAL A 273
THR A 274
ALA A 299
 FAD  A 487 (-3.3A)
FAD  A 487 (-2.5A)
None
None
None
 1.04A 5kocA-3kveA:
2.4		 5kocA-3kveA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 GLY A 154
VAL A 133
VAL A 160
ALA A 161
LEU A 162
 None
 1.00A 5kocA-3l76A:
2.9		 5kocA-3l76A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 GLY A  34
ASP A  59
VAL A  60
THR A  61
VAL A  84
 None
 1.00A 5kocA-3m1aA:
5.0		 5kocA-3m1aA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLY A 118
GLN A  90
VAL A 180
ALA A 124
LEU A 123
 None
 1.02A 5kocA-3m4xA:
10.5		 5kocA-3m4xA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 GLY A 660
VAL A 529
THR A 528
ALA A 581
LEU A 580
 None
None
PO4  A 768 (-4.5A)
None
None
 1.06A 5kocA-3o8lA:
undetectable		 5kocA-3o8lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 SER A 201
ASN A 253
ALA A 272
LEU A 273
HIS A 277
 MLI  A 901 (-2.4A)
None
None
None
None
 1.08A 5kocA-3odmA:
undetectable		 5kocA-3odmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogj PRKG1 PROTEIN

(Homo sapiens) 		PF00027
(cNMP_binding) 		5 GLY A 182
VAL A 163
THR A 198
ALA A 206
LEU A 204
 CMP  A 250 (-3.2A)
None
None
None
None
 1.05A 5kocA-3ogjA:
undetectable		 5kocA-3ogjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 102
ASP A  80
VAL A  81
ALA A 109
LEU A 108
 None
 1.03A 5kocA-3om8A:
undetectable		 5kocA-3om8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snk RESPONSE REGULATOR
CHEY-LIKE PROTEIN

(Mesorhizobium
loti) 		no annotation 5 SER A  20
VAL A 126
THR A 127
ALA A  30
LEU A  33
 None
 1.07A 5kocA-3snkA:
2.8		 5kocA-3snkA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 GLY A  36
ASP A  61
VAL A  62
THR A  63
VAL A  86
 None
 1.03A 5kocA-3tpcA:
4.4		 5kocA-3tpcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A  20
VAL A  51
THR A  52
ALA A  37
LEU A  36
 CL  A 261 (-3.8A)
None
None
None
None
 1.04A 5kocA-3ucxA:
5.4		 5kocA-3ucxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		5 GLY A 138
VAL A 225
VAL A 242
ALA A 278
LEU A 243
 None
 1.07A 5kocA-3vovA:
undetectable		 5kocA-3vovA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		5 GLY A  14
ASP A  53
VAL A  54
THR A  55
VAL A  78
 None
 1.06A 5kocA-3vtzA:
4.5		 5kocA-3vtzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 300
ASP A1072
VAL A1071
VAL A1094
ALA A1093
 None
 1.02A 5kocA-3vw7A:
undetectable		 5kocA-3vw7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Mycobacterium
tuberculosis) 		PF01116
(F_bP_aldolase) 		5 VAL A  34
THR A  33
VAL A  73
ALA A  72
LEU A  75
 None
 1.08A 5kocA-4a22A:
undetectable		 5kocA-4a22A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 271
THR A 270
VAL A 258
ALA A 255
LEU A 257
 None
 0.98A 5kocA-4a73A:
3.8		 5kocA-4a73A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 GLY A1117
VAL A1082
VAL A1122
ALA A1123
LEU A1124
 None
 0.92A 5kocA-4f4cA:
undetectable		 5kocA-4f4cA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		6 PHE A  86
GLY A 203
VAL A 104
THR A 105
ALA A 198
LEU A 197
 None
 1.44A 5kocA-4ia4A:
undetectable		 5kocA-4ia4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 ASN A 152
THR A 147
VAL A 185
ALA A 115
LEU A 116
 None
PEG  A 309 (-4.1A)
PEG  A 311 (-4.6A)
PEG  A 307 (-3.2A)
None
 1.11A 5kocA-4kptA:
undetectable		 5kocA-4kptA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 5 GLY A 336
THR A 377
VAL A 343
ALA A 333
LEU A 342
 None
 0.99A 5kocA-4lr4A:
undetectable		 5kocA-4lr4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		5 PHE A 116
GLY A 124
SER A 121
VAL A 111
LEU A 113
 None
 1.10A 5kocA-4mf4A:
undetectable		 5kocA-4mf4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 VAL A 255
THR A 254
VAL A 237
ALA A 234
LEU A 236
 None
 1.10A 5kocA-4p53A:
undetectable		 5kocA-4p53A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A 103
VAL A 110
THR A 131
VAL A  97
ALA A  96
 None
 0.95A 5kocA-4rvhA:
13.0		 5kocA-4rvhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 306
ASP A 229
VAL A 230
VAL A 245
LEU A 303
 None
 1.10A 5kocA-4rybA:
undetectable		 5kocA-4rybA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 GLY P 120
ASP P 154
VAL P 153
VAL P  65
LEU P  33
 None
 0.96A 5kocA-4s2tP:
undetectable		 5kocA-4s2tP:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 GLY A  15
ASP A  64
VAL A  65
THR A  66
VAL A 141
 None
 0.93A 5kocA-4weoA:
5.2		 5kocA-4weoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		5 ASP A 121
VAL A 122
THR A 123
VAL A 102
LEU A 103
 None
 0.92A 5kocA-4wmjA:
undetectable		 5kocA-4wmjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A  80
GLN A 104
VAL A 157
VAL A  57
ALA A  58
 None
 1.04A 5kocA-4wr3A:
undetectable		 5kocA-4wr3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 GLY A 300
ASP A 284
THR A 322
ALA A 306
LEU A 305
 None
 0.85A 5kocA-4yn5A:
undetectable		 5kocA-4yn5A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z07 CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		PF00027
(cNMP_binding) 		5 GLY A 182
VAL A 163
THR A 198
ALA A 206
LEU A 204
 PCG  A 401 (-3.4A)
None
None
None
None
 1.09A 5kocA-4z07A:
undetectable		 5kocA-4z07A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 SER A1414
ASN A1478
VAL A1476
ALA A1461
LEU A1165
 None
 1.10A 5kocA-5a42A:
undetectable		 5kocA-5a42A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 GLY A 215
ASN A 340
VAL A 171
ALA A 221
LEU A 222
 ANP  A 701 (-3.2A)
None
None
None
None
 1.08A 5kocA-5dgkA:
undetectable		 5kocA-5dgkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  26
ASP A 101
VAL A   5
ALA A  23
LEU A   4
 None
 1.07A 5kocA-5dq9A:
undetectable		 5kocA-5dq9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejk GAG-PRO-POL
POLYPROTEIN

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 GLY A  56
GLN A  59
VAL A 241
ALA A 248
LEU A 240
 None
 1.03A 5kocA-5ejkA:
undetectable		 5kocA-5ejkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f72 SINGLE CHAIN FV FROM
A FAB

(Homo sapiens) 		no annotation 6 GLY T  26
ASP T 109
VAL T 110
VAL T   5
ALA T  23
LEU T   4
 None
 1.45A 5kocA-5f72T:
undetectable		 5kocA-5f72T:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gua 149AA LONG
HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE GAMMA
CHAIN

(Pyrococcus
horikoshii) 		PF00364
(Biotin_lipoyl) 		5 GLY A 136
ASP A 140
THR A 141
VAL A 110
LEU A 111
 None
 1.00A 5kocA-5guaA:
undetectable		 5kocA-5guaA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifg MRNA INTERFERASE
HIGB

(Escherichia
coli) 		PF09907
(HigB_toxin) 		5 GLY A  63
VAL A  69
VAL A  24
ALA A  25
LEU A  26
 None
 1.08A 5kocA-5ifgA:
undetectable		 5kocA-5ifgA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		12 PHE A  96
GLY A 137
SER A 140
ASN A 159
GLN A 163
ASP A 185
VAL A 186
THR A 187
VAL A 201
ALA A 202
LEU A 203
HIS A 206
 None
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.9A)
 0.26A 5kocA-5kpgA:
54.7		 5kocA-5kpgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 GLY A 631
SER A 675
VAL A 664
ALA A 637
LEU A 641
 None
 1.09A 5kocA-5l46A:
2.2		 5kocA-5l46A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 GLY A 499
ASN A 443
THR A 464
VAL A 536
ALA A 496
 None
 1.04A 5kocA-5m6gA:
undetectable		 5kocA-5m6gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		5 GLN A  69
VAL A 219
VAL A 235
ALA A 238
LEU A 239
 None
 1.08A 5kocA-5mtvA:
undetectable		 5kocA-5mtvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr4 CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		no annotation 5 GLY A  71
ASP A  80
VAL A  79
ALA A 112
LEU A 115
 None
 0.95A 5kocA-5nr4A:
undetectable		 5kocA-5nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 GLY A  40
SER A  44
VAL A 273
THR A 274
ALA A 299
 FAD  A 501 (-3.2A)
FAD  A 501 (-2.5A)
None
None
None
 1.04A 5kocA-5ts5A:
3.0		 5kocA-5ts5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		5 ASN A 278
VAL A 282
VAL A 117
ALA A 116
LEU A 119
 None
 0.96A 5kocA-5viuA:
undetectable		 5kocA-5viuA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		5 ASP A 281
VAL A 282
VAL A 117
ALA A 116
LEU A 119
 None
 1.03A 5kocA-5viuA:
undetectable		 5kocA-5viuA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A  63
ASP A 107
VAL A 108
THR A 109
LEU A 128
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
SAH  A 701 ( 4.6A)
None
 0.66A 5kocA-5wp4A:
23.1		 5kocA-5wp4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A  63
ASP A 107
VAL A 108
THR A 109
LEU A 128
 SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
SAH  A 502 ( 4.8A)
None
 0.69A 5kocA-5wp5A:
22.1		 5kocA-5wp5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 GLY A 390
VAL A 425
VAL A 383
ALA A 382
LEU A 385
 None
 1.10A 5kocA-5xnzA:
undetectable		 5kocA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtk XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		no annotation 5 GLY A  31
VAL A 110
THR A 111
ALA A  47
LEU A  46
 None
 1.05A 5kocA-5xtkA:
undetectable		 5kocA-5xtkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y28 -

(-) 		no annotation 5 GLY A 277
ASN A 335
THR A 330
VAL A 322
LEU A 280
 EDO  A 401 ( 4.7A)
None
None
None
None
 1.05A 5kocA-5y28A:
undetectable		 5kocA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 GLY A 613
VAL A 625
THR A 624
ALA A 636
LEU A 635
 None
 0.83A 5kocA-5z0uA:
undetectable		 5kocA-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 ASP A  82
VAL A  83
VAL A 146
LEU A  61
HIS A  62
 None
 0.94A 5kocA-6dinA:
undetectable		 5kocA-6dinA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 7 GLY A 139
ASN A 161
GLN A 165
ASP A 187
THR A 189
LEU A 205
HIS A 208
 SAH  A 501 (-3.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.7A)
SAH  A 501 (-4.2A)
None
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.6A)
 0.66A 5kocA-6gkvA:
48.5		 5kocA-6gkvA:
undetectable