SIMILAR PATTERNS OF AMINO ACIDS FOR 5KMD_C_6UBC1304_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a05 | 3-ISOPROPYLMALATEDEHYDROGENASE (Acidithiobacillusferrooxidans) |
PF00180(Iso_dh) | 4 | TYR A 140ILE A 139LEU A 248GLY A 245 | IPM A 401 (-4.5A)NoneNoneNone | 0.76A | 5kmdC-1a05A:0.25kmdD-1a05A:undetectable | 5kmdC-1a05A:21.495kmdD-1a05A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aok | VIPOXIN COMPLEX (Viperaammodytes) |
PF00068(Phospholip_A2_1) | 4 | TYR B 75ILE B 82LEU B 2PHE B 5 | NoneNoneNoneACT B 134 (-4.6A) | 0.91A | 5kmdC-1aokB:0.05kmdD-1aokB:undetectable | 5kmdC-1aokB:14.045kmdD-1aokB:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1chm | CREATINEAMIDINOHYDROLASE (Pseudomonasputida) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ILE A 380LEU A 329GLY A 327PHE A 326 | None | 0.83A | 5kmdC-1chmA:0.05kmdD-1chmA:0.0 | 5kmdC-1chmA:21.985kmdD-1chmA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjy | PROTEIN (CYTOSOLICPHOSPHOLIPASE A2) (Homo sapiens) |
PF00168(C2)PF01735(PLA2_B) | 4 | TYR A 275ILE A 294LEU A 303GLY A 300 | None | 0.93A | 5kmdC-1cjyA:undetectable5kmdD-1cjyA:1.0 | 5kmdC-1cjyA:18.445kmdD-1cjyA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 4 | TYR A 145ILE A 144LEU A 253GLY A 250 | SO4 A 902 (-4.5A)NoneNoneNone | 0.79A | 5kmdC-1cnzA:0.05kmdD-1cnzA:undetectable | 5kmdC-1cnzA:19.895kmdD-1cnzA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dt2 | EXFOLIATIVE TOXIN B (Staphylococcusaureus) |
PF13365(Trypsin_2) | 4 | ILE A 144LEU A 238GLY A 235PHE A 216 | None | 0.84A | 5kmdC-1dt2A:undetectable5kmdD-1dt2A:undetectable | 5kmdC-1dt2A:22.225kmdD-1dt2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fot | CAMP-DEPENDENTPROTEIN KINASE TYPE1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 4 | ILE A 216LEU A 316GLY A 269PHE A 268 | None | 0.91A | 5kmdC-1fotA:2.65kmdD-1fotA:1.8 | 5kmdC-1fotA:20.665kmdD-1fotA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0z | PHOSPHOLIPASE A2 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 4 | TYR A 70ILE A 77LEU A 2PHE A 5 | None | 0.92A | 5kmdC-1g0zA:0.55kmdD-1g0zA:undetectable | 5kmdC-1g0zA:16.095kmdD-1g0zA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idm | 3-ISOPROPYLMALATEDEHYDROGENASE (Thermusthermophilus) |
PF00180(Iso_dh) | 4 | TYR A 137ILE A 136LEU A 241GLY A 238 | None | 0.85A | 5kmdC-1idmA:undetectable5kmdD-1idmA:undetectable | 5kmdC-1idmA:22.475kmdD-1idmA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jxk | ALPHA-AMYLASE,SALIVARY (Homo sapiens) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 4 | TYR A 444ILE A 462GLY A 420PHE A 421 | None | 0.93A | 5kmdC-1jxkA:undetectable5kmdD-1jxkA:undetectable | 5kmdC-1jxkA:18.185kmdD-1jxkA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mvl | PPC DECARBOXYLASEATHAL3A (Arabidopsisthaliana) |
PF02441(Flavoprotein) | 4 | ILE A 189LEU A 65GLY A 36PHE A 35 | None | 0.95A | 5kmdC-1mvlA:undetectable5kmdD-1mvlA:undetectable | 5kmdC-1mvlA:22.605kmdD-1mvlA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzt | BETA-1,4-GALACTOSYLTRANSFERASE 1 (Bos taurus) |
PF02709(Glyco_transf_7C)PF13733(Glyco_transf_7N) | 4 | TYR A 216ILE A 394LEU A 167GLY A 168 | None | 0.84A | 5kmdC-1pztA:undetectable5kmdD-1pztA:undetectable | 5kmdC-1pztA:19.575kmdD-1pztA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | ILE A 82LEU A 89GLY A 86PHE A 85 | None | 0.96A | 5kmdC-1sivA:undetectable5kmdD-1sivA:undetectable | 5kmdC-1sivA:15.095kmdD-1sivA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4g | GLUTAMATE--CYSTEINELIGASE (Escherichiacoli) |
PF04262(Glu_cys_ligase) | 4 | TYR A 326ILE A 327LEU A 26GLY A 25 | None | 0.97A | 5kmdC-1v4gA:undetectable5kmdD-1v4gA:undetectable | 5kmdC-1v4gA:19.925kmdD-1v4gA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpi | PHOSPHOLIPASE A2INHIBITOR (Viperaammodytes) |
PF00068(Phospholip_A2_1) | 4 | TYR A 75ILE A 82LEU A 2PHE A 5 | None | 0.94A | 5kmdC-1vpiA:0.15kmdD-1vpiA:undetectable | 5kmdC-1vpiA:15.865kmdD-1vpiA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 4 | ILE A 265LEU A 253GLY A 252PHE A 254 | None | 0.95A | 5kmdC-1w1kA:undetectable5kmdD-1w1kA:undetectable | 5kmdC-1w1kA:19.905kmdD-1w1kA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3b | UDP-N-ACETYLGLUCOSAMINE--PEPTIDEN-ACETYLGLUCOSAMINYLTRANSFERASE 110 (Homo sapiens) |
PF00515(TPR_1)PF13181(TPR_8)PF13414(TPR_11)PF13424(TPR_12) | 4 | ILE A 197LEU A 187GLY A 188PHE A 191 | None | 0.70A | 5kmdC-1w3bA:undetectable5kmdD-1w3bA:undetectable | 5kmdC-1w3bA:21.325kmdD-1w3bA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y60 | FORMALDEHYDE-ACTIVATING ENZYME FAE (Methylobacteriumextorquens) |
PF08714(Fae) | 4 | ILE A 26LEU A 42GLY A 41PHE A 38 | None | 0.96A | 5kmdC-1y60A:undetectable5kmdD-1y60A:undetectable | 5kmdC-1y60A:21.145kmdD-1y60A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z47 | PUTATIVEABC-TRANSPORTERATP-BINDING PROTEIN (Alicyclobacillusacidocaldarius) |
PF00005(ABC_tran)PF08402(TOBE_2) | 4 | TYR A 24ILE A 23LEU A 219GLY A 53 | NoneNoneNone CL A 401 (-3.3A) | 0.90A | 5kmdC-1z47A:undetectable5kmdD-1z47A:undetectable | 5kmdC-1z47A:21.565kmdD-1z47A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayu | NUCLEOSOME ASSEMBLYPROTEIN (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | TYR A 266LEU A 222GLY A 228PHE A 253 | None | 0.73A | 5kmdC-2ayuA:undetectable5kmdD-2ayuA:undetectable | 5kmdC-2ayuA:19.015kmdD-2ayuA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ctr | DNAJ HOMOLOGSUBFAMILY B MEMBER 9 (Homo sapiens) |
PF00226(DnaJ) | 4 | TYR A 10LEU A 71GLY A 72PHE A 76 | None | 0.90A | 5kmdC-2ctrA:2.15kmdD-2ctrA:3.2 | 5kmdC-2ctrA:13.505kmdD-2ctrA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cy7 | CYSTEINE PROTEASEAPG4B (Homo sapiens) |
PF03416(Peptidase_C54) | 4 | TYR A 265ILE A 256LEU A 87PHE A 83 | None | 0.81A | 5kmdC-2cy7A:undetectable5kmdD-2cy7A:undetectable | 5kmdC-2cy7A:19.955kmdD-2cy7A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | TYR A 162ILE A 150LEU A 67GLY A 66PHE A 105 | None | 1.35A | 5kmdC-2g3nA:undetectable5kmdD-2g3nA:undetectable | 5kmdC-2g3nA:18.915kmdD-2g3nA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h4c | PHOSPHOLIPASE A2-II (Daboiasiamensis) |
PF00068(Phospholip_A2_1) | 4 | TYR B 75ILE B 82LEU B 2PHE B 5 | None | 0.79A | 5kmdC-2h4cB:undetectable5kmdD-2h4cB:undetectable | 5kmdC-2h4cB:14.295kmdD-2h4cB:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7g | MONOOXYGENASE (Agrobacteriumfabrum) |
PF00296(Bac_luciferase) | 5 | TYR A 330ILE A 327LEU A 287GLY A 237PHE A 238 | None | 1.43A | 5kmdC-2i7gA:undetectable5kmdD-2i7gA:undetectable | 5kmdC-2i7gA:20.935kmdD-2i7gA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixd | LMBE-RELATED PROTEIN (Bacillus cereus) |
PF02585(PIG-L) | 4 | ILE A 6LEU A 39GLY A 10PHE A 9 | None | 0.92A | 5kmdC-2ixdA:undetectable5kmdD-2ixdA:undetectable | 5kmdC-2ixdA:21.575kmdD-2ixdA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5b | TYROSYL-TRNASYNTHETASE (Acanthamoebapolyphagamimivirus) |
PF00579(tRNA-synt_1b) | 4 | ILE A 67LEU A 90GLY A 91PHE A 94 | ILE A 67 ( 0.7A)LEU A 90 ( 0.6A)GLY A 91 ( 0.0A)PHE A 94 ( 1.3A) | 0.87A | 5kmdC-2j5bA:undetectable5kmdD-2j5bA:undetectable | 5kmdC-2j5bA:22.875kmdD-2j5bA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz2 | ARGININOSUCCINATESYNTHASE (Homo sapiens) |
PF00764(Arginosuc_synth) | 4 | TYR A 282ILE A 266LEU A 93GLY A 90 | None | 0.72A | 5kmdC-2nz2A:undetectable5kmdD-2nz2A:undetectable | 5kmdC-2nz2A:21.365kmdD-2nz2A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o4t | BH3976 PROTEIN (Bacillushalodurans) |
PF06304(DUF1048) | 4 | TYR A 31ILE A 34GLY A 58PHE A 59 | None | 0.94A | 5kmdC-2o4tA:3.05kmdD-2o4tA:undetectable | 5kmdC-2o4tA:15.225kmdD-2o4tA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ocd | L-ASPARAGINASE I (Vibrio cholerae) |
PF00710(Asparaginase) | 4 | TYR A 312ILE A 208LEU A 108PHE A 105 | None | 0.90A | 5kmdC-2ocdA:undetectable5kmdD-2ocdA:undetectable | 5kmdC-2ocdA:21.535kmdD-2ocdA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osn | PHOSPHOLIPASE A2ISOFORM 3 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 4 | TYR A 70ILE A 77LEU A 4PHE A 7 | None | 0.90A | 5kmdC-2osnA:undetectable5kmdD-2osnA:undetectable | 5kmdC-2osnA:16.415kmdD-2osnA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pv7 | T-PROTEIN [INCLUDES:CHORISMATE MUTASE(EC 5.4.99.5) (CM)AND PREPHENATEDEHYDROGENASE (EC1.3.1.12) (PDH)] (Haemophilusinfluenzae) |
PF02153(PDH) | 4 | ILE A 103LEU A 112GLY A 113PHE A 116 | NoneNAD A 400 (-4.0A)NoneNone | 0.63A | 5kmdC-2pv7A:undetectable5kmdD-2pv7A:undetectable | 5kmdC-2pv7A:24.235kmdD-2pv7A:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qh5 | MANNOSE-6-PHOSPHATEISOMERASE (Helicobacterpylori) |
PF00483(NTP_transferase) | 4 | ILE A 255LEU A 260GLY A 140PHE A 139 | None | 0.92A | 5kmdC-2qh5A:undetectable5kmdD-2qh5A:undetectable | 5kmdC-2qh5A:23.055kmdD-2qh5A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzn | VENOM ALLERGEN 3 (Solenopsisinvicta) |
PF00188(CAP) | 4 | ILE A 147LEU A 203GLY A 204PHE A 150 | None | 0.82A | 5kmdC-2vznA:undetectable5kmdD-2vznA:undetectable | 5kmdC-2vznA:18.825kmdD-2vznA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwb | COMPLEMENT C3BALPHA' CHAIN (Homo sapiens) |
PF00207(A2M)PF01759(NTR)PF07677(A2M_recep)PF07678(A2M_comp)PF10569(Thiol-ester_cl) | 4 | TYR B1523ILE B1547LEU B1585GLY B1584 | None | 0.95A | 5kmdC-2xwbB:undetectable5kmdD-2xwbB:1.6 | 5kmdC-2xwbB:14.675kmdD-2xwbB:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2r | NUCLEOSOME ASSEMBLYPROTEIN (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | TYR A 266LEU A 222GLY A 228PHE A 253 | None | 0.83A | 5kmdC-2z2rA:undetectable5kmdD-2z2rA:undetectable | 5kmdC-2z2rA:20.865kmdD-2z2rA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8e | YGHU, GLUTATHIONES-TRANSFERASEHOMOLOGUE (Escherichiacoli) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | TYR A 167LEU A 157GLY A 158PHE A 161 | NoneNoneGSH A 290 (-3.4A)None | 0.93A | 5kmdC-3c8eA:2.45kmdD-3c8eA:2.5 | 5kmdC-3c8eA:22.575kmdD-3c8eA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ced | METHIONINE IMPORTATP-BINDING PROTEINMETN 2 (Staphylococcusaureus) |
PF09383(NIL) | 4 | TYR A 287ILE A 289GLY A 322PHE A 321 | None | 0.70A | 5kmdC-3cedA:undetectable5kmdD-3cedA:undetectable | 5kmdC-3cedA:15.095kmdD-3cedA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpg | UNCHARACTERIZEDPROTEIN (Bifidobacteriumadolescentis) |
PF01168(Ala_racemase_N) | 4 | ILE A 138LEU A 101GLY A 102PHE A 117 | None | 0.93A | 5kmdC-3cpgA:undetectable5kmdD-3cpgA:undetectable | 5kmdC-3cpgA:18.585kmdD-3cpgA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fid | PUTATIVE OUTERMEMBRANE PROTEIN(LPXR) (Salmonellaenterica) |
PF09982(DUF2219) | 4 | TYR A 287ILE A 288LEU A 37GLY A 36 | None | 0.96A | 5kmdC-3fidA:undetectable5kmdD-3fidA:undetectable | 5kmdC-3fidA:21.165kmdD-3fidA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hfw | PROTEINADP-RIBOSYLARGININEHYDROLASE (Homo sapiens) |
PF03747(ADP_ribosyl_GH) | 4 | ILE A 277LEU A 17GLY A 18PHE A 297 | None | 0.87A | 5kmdC-3hfwA:undetectable5kmdD-3hfwA:undetectable | 5kmdC-3hfwA:20.385kmdD-3hfwA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3inn | PANTOTHENATESYNTHETASE (Brucellamelitensis) |
PF02569(Pantoate_ligase) | 4 | ILE A 170LEU A 52GLY A 25PHE A 26 | None | 0.96A | 5kmdC-3innA:undetectable5kmdD-3innA:undetectable | 5kmdC-3innA:20.065kmdD-3innA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4g | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Homo sapiens) |
PF03483(B3_4)PF03484(B5) | 4 | TYR B 374LEU B 33GLY B 32PHE B 31 | None | 0.89A | 5kmdC-3l4gB:undetectable5kmdD-3l4gB:undetectable | 5kmdC-3l4gB:18.845kmdD-3l4gB:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lk6 | LIPOPROTEIN YBBD (Bacillussubtilis) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 4 | ILE A 179LEU A 144GLY A 145PHE A 193 | None | 0.90A | 5kmdC-3lk6A:3.25kmdD-3lk6A:2.3 | 5kmdC-3lk6A:18.615kmdD-3lk6A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3men | ACETYLPOLYAMINEAMINOHYDROLASE (Burkholderiapseudomallei) |
PF00850(Hist_deacetyl) | 4 | TYR A 320LEU A 278GLY A 279PHE A 280 | SO4 A 401 (-4.5A)NoneNoneNone | 0.89A | 5kmdC-3menA:undetectable5kmdD-3menA:undetectable | 5kmdC-3menA:19.205kmdD-3menA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfv | ALGINATE LYASE (Bacteroidesovatus) |
PF05426(Alginate_lyase) | 4 | TYR A 187ILE A 184LEU A 300GLY A 301 | NoneNoneNoneEDO A 412 (-3.5A) | 0.91A | 5kmdC-3nfvA:undetectable5kmdD-3nfvA:undetectable | 5kmdC-3nfvA:20.055kmdD-3nfvA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p2p | PHOSPHOLIPASE A2 (Sus scrofa) |
PF00068(Phospholip_A2_1) | 4 | TYR A 75ILE A 82LEU A 2PHE A 5 | None | 0.93A | 5kmdC-3p2pA:undetectable5kmdD-3p2pA:undetectable | 5kmdC-3p2pA:13.995kmdD-3p2pA:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qkc | GERANYL DIPHOSPHATESYNTHASE SMALLSUBUNIT (Antirrhinummajus) |
no annotation | 4 | TYR B 20ILE B 17LEU B 120GLY B 119 | None | 0.93A | 5kmdC-3qkcB:undetectable5kmdD-3qkcB:2.3 | 5kmdC-3qkcB:20.825kmdD-3qkcB:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2w | TRANSCRIPTIONALREGULATOR, MARRFAMILY (Methanosarcinamazei) |
PF01047(MarR) | 4 | ILE A 25LEU A 153GLY A 152PHE A 149 | ILE A 25 ( 0.7A)LEU A 153 ( 0.6A)GLY A 152 ( 0.0A)PHE A 149 ( 1.3A) | 0.90A | 5kmdC-3s2wA:undetectable5kmdD-3s2wA:2.3 | 5kmdC-3s2wA:17.025kmdD-3s2wA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubd | RIBOSOMAL PROTEIN S6KINASE ALPHA-3 (Mus musculus) |
PF00069(Pkinase) | 4 | ILE A 199LEU A 302GLY A 255PHE A 254 | None | 0.85A | 5kmdC-3ubdA:undetectable5kmdD-3ubdA:1.4 | 5kmdC-3ubdA:22.925kmdD-3ubdA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udu | 3-ISOPROPYLMALATEDEHYDROGENASE (Campylobacterjejuni) |
PF00180(Iso_dh) | 4 | TYR A 144ILE A 143LEU A 247GLY A 244 | None | 0.93A | 5kmdC-3uduA:undetectable5kmdD-3uduA:undetectable | 5kmdC-3uduA:22.995kmdD-3uduA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ure | ALPHA-LYTIC PROTEASE (Lysobacterenzymogenes) |
PF00089(Trypsin) | 4 | ILE A 234LEU A 108GLY A 51PHE A 52 | None | 0.94A | 5kmdC-3ureA:undetectable5kmdD-3ureA:undetectable | 5kmdC-3ureA:20.965kmdD-3ureA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vm5 | ALPHA-AMYLASE (Oryzias latipes) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 4 | TYR A 450ILE A 468GLY A 426PHE A 427 | None | 0.90A | 5kmdC-3vm5A:undetectable5kmdD-3vm5A:undetectable | 5kmdC-3vm5A:19.925kmdD-3vm5A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vxi | DYP (Bjerkanderaadusta) |
PF04261(Dyp_perox) | 4 | ILE A 146LEU A 76GLY A 75PHE A 71 | None | 0.92A | 5kmdC-3vxiA:undetectable5kmdD-3vxiA:undetectable | 5kmdC-3vxiA:20.995kmdD-3vxiA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6x | MPR1 PROTEIN (Saccharomycescerevisiae) |
no annotation | 4 | ILE A 69LEU A 87GLY A 85PHE A 86 | None | 0.92A | 5kmdC-3w6xA:undetectable5kmdD-3w6xA:undetectable | 5kmdC-3w6xA:23.635kmdD-3w6xA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh9 | ENDO-BETA-1,4-MANNANASE (Aspergillusniger) |
PF00150(Cellulase) | 4 | ILE A 183LEU A 208GLY A 207PHE A 226 | None | 0.95A | 5kmdC-3wh9A:undetectable5kmdD-3wh9A:undetectable | 5kmdC-3wh9A:18.565kmdD-3wh9A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wme | ATP-BINDINGCASSETTE, SUB-FAMILYB, MEMBER 1 (Cyanidioschyzonmerolae) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | TYR A 163LEU A 380GLY A 143PHE A 142 | None | 0.89A | 5kmdC-3wmeA:3.85kmdD-3wmeA:4.2 | 5kmdC-3wmeA:19.325kmdD-3wmeA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x29 | CLAUDIN-19 (Mus musculus) |
PF00822(PMP22_Claudin) | 4 | ILE A 21LEU A 182GLY A 179PHE A 126 | None | 0.96A | 5kmdC-3x29A:undetectable5kmdD-3x29A:2.5 | 5kmdC-3x29A:20.915kmdD-3x29A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bb9 | GLUCOKINASEREGULATORY PROTEIN (Homo sapiens) |
no annotation | 5 | TYR A 468ILE A 285LEU A 464GLY A 470PHE A 466 | None | 1.23A | 5kmdC-4bb9A:5.55kmdD-4bb9A:2.7 | 5kmdC-4bb9A:17.985kmdD-4bb9A:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4blq | P4 (Pseudomonasphage phi8) |
PF11602(NTPase_P4) | 4 | ILE A 48LEU A 59GLY A 60PHE A 61 | None | 0.95A | 5kmdC-4blqA:undetectable5kmdD-4blqA:undetectable | 5kmdC-4blqA:22.475kmdD-4blqA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czw | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Neurosporacrassa) |
PF00929(RNase_T)PF13423(UCH_1) | 4 | TYR A 665ILE A 680LEU A 690GLY A 689 | None | 0.95A | 5kmdC-4czwA:undetectable5kmdD-4czwA:undetectable | 5kmdC-4czwA:18.435kmdD-4czwA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewj | ENOLASE 2 (Streptococcussuis) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | TYR A 231ILE A 226LEU A 179GLY A 178 | None | 0.90A | 5kmdC-4ewjA:undetectable5kmdD-4ewjA:undetectable | 5kmdC-4ewjA:20.675kmdD-4ewjA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 4 | ILE A 836LEU A 909GLY A 908PHE A 832 | None | 0.92A | 5kmdC-4ifqA:3.75kmdD-4ifqA:3.8 | 5kmdC-4ifqA:15.265kmdD-4ifqA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwh | 3-ISOPROPYLMALATEDEHYDROGENASE (Burkholderiathailandensis) |
PF00180(Iso_dh) | 4 | TYR A 135ILE A 134LEU A 248GLY A 245 | None | 0.87A | 5kmdC-4iwhA:undetectable5kmdD-4iwhA:undetectable | 5kmdC-4iwhA:19.335kmdD-4iwhA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l95 | GAMMA-GLUTAMYLHYDROLASE (Danio rerio) |
no annotation | 4 | TYR E 34LEU E 113GLY E 110PHE E 69 | None | 0.96A | 5kmdC-4l95E:undetectable5kmdD-4l95E:undetectable | 5kmdC-4l95E:22.265kmdD-4l95E:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ljs | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 4 | ILE A 34LEU A 177GLY A 178PHE A 181 | None | 0.94A | 5kmdC-4ljsA:undetectable5kmdD-4ljsA:undetectable | 5kmdC-4ljsA:21.615kmdD-4ljsA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mb5 | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18)PF16403(DUF5011) | 4 | ILE A 264LEU A 273GLY A 272PHE A 271 | None | 0.91A | 5kmdC-4mb5A:undetectable5kmdD-4mb5A:undetectable | 5kmdC-4mb5A:18.105kmdD-4mb5A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzw | GLUTATHIONES-TRANSFERASE (Streptococcussanguinis) |
PF02798(GST_N)PF13410(GST_C_2) | 4 | TYR A 164LEU A 154GLY A 155PHE A 158 | NoneNoneGDS A 301 (-3.3A)None | 0.93A | 5kmdC-4mzwA:2.35kmdD-4mzwA:2.6 | 5kmdC-4mzwA:22.915kmdD-4mzwA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nlm | LMO1340 PROTEIN (Listeriamonocytogenes) |
no annotation | 4 | TYR A 206ILE A 219LEU A 202GLY A 203 | None | 0.66A | 5kmdC-4nlmA:undetectable5kmdD-4nlmA:undetectable | 5kmdC-4nlmA:23.365kmdD-4nlmA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om9 | SERINE PROTEASE PET (Escherichiacoli) |
PF02395(Peptidase_S6) | 4 | ILE A 343LEU A 311GLY A 315PHE A 316 | None | 0.93A | 5kmdC-4om9A:undetectable5kmdD-4om9A:undetectable | 5kmdC-4om9A:16.375kmdD-4om9A:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT D (Vibrio cholerae) |
PF02508(Rnf-Nqr) | 4 | ILE D 191LEU D 16GLY D 140PHE D 143 | None | 0.76A | 5kmdC-4p6vD:undetectable5kmdD-4p6vD:1.6 | 5kmdC-4p6vD:25.445kmdD-4p6vD:25.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r89 | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF08774(VRR_NUC) | 4 | TYR A 37ILE A 33GLY A 181PHE A 180 | None | 0.93A | 5kmdC-4r89A:undetectable5kmdD-4r89A:undetectable | 5kmdC-4r89A:16.645kmdD-4r89A:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5z | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18) | 4 | ILE A 264LEU A 273GLY A 272PHE A 271 | None | 0.92A | 5kmdC-4w5zA:undetectable5kmdD-4w5zA:undetectable | 5kmdC-4w5zA:20.555kmdD-4w5zA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wwj | TENA/THI-4 FAMILYPROTEIN (Pseudomonasprotegens) |
PF14518(Haem_oxygenas_2) | 4 | ILE A 208LEU A 215GLY A 214PHE A 5 | None | 0.94A | 5kmdC-4wwjA:undetectable5kmdD-4wwjA:undetectable | 5kmdC-4wwjA:19.015kmdD-4wwjA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk1 | PHOSPHOSERINEAMINOTRANSFERASE (Pseudomonasaeruginosa) |
PF00266(Aminotran_5) | 4 | ILE A 64LEU A 170GLY A 189PHE A 188 | None | 0.93A | 5kmdC-4xk1A:undetectable5kmdD-4xk1A:undetectable | 5kmdC-4xk1A:22.665kmdD-4xk1A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysl | BETA-LACTAMASEDOMAIN PROTEIN (Pseudomonasputida) |
PF00753(Lactamase_B) | 4 | ILE A 100LEU A 110GLY A 108PHE A 107 | None | 0.95A | 5kmdC-4yslA:undetectable5kmdD-4yslA:undetectable | 5kmdC-4yslA:21.175kmdD-4yslA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxz | LEVOGLUCOSAN KINASE (Lipomycesstarkeyi) |
PF03702(AnmK) | 4 | ILE A 110LEU A 85GLY A 86PHE A 89 | None | 0.69A | 5kmdC-4zxzA:undetectable5kmdD-4zxzA:undetectable | 5kmdC-4zxzA:17.925kmdD-4zxzA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cgl | ADENOSINEMONOPHOSPHATE-PROTEIN TRANSFERASE NMFIC (Neisseriameningitidis) |
PF02661(Fic) | 5 | TYR A 48ILE A 45LEU A 53GLY A 51PHE A 50 | None | 1.48A | 5kmdC-5cglA:undetectable5kmdD-5cglA:undetectable | 5kmdC-5cglA:19.655kmdD-5cglA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | ILE A 682LEU A 469GLY A 468PHE A 465 | None | 0.96A | 5kmdC-5chcA:undetectable5kmdD-5chcA:undetectable | 5kmdC-5chcA:15.655kmdD-5chcA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5di0 | NATTERIN-LIKEPROTEIN (Danio rerio) |
PF03318(ETX_MTX2) | 4 | ILE A 9LEU A 29GLY A 125PHE A 139 | PEG A 408 (-4.3A)NoneNoneNone | 0.78A | 5kmdC-5di0A:undetectable5kmdD-5di0A:undetectable | 5kmdC-5di0A:24.665kmdD-5di0A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dwa | TYPE-2 RESTRICTIONENZYME AGEI (Thalassobiusgelatinovorus) |
no annotation | 4 | TYR A 31ILE A 28GLY A 48PHE A 51 | None | 0.95A | 5kmdC-5dwaA:undetectable5kmdD-5dwaA:undetectable | 5kmdC-5dwaA:22.295kmdD-5dwaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 4 | ILE A 330LEU A 364GLY A 362PHE A 365 | None | 0.95A | 5kmdC-5gnmA:undetectable5kmdD-5gnmA:1.5 | 5kmdC-5gnmA:20.485kmdD-5gnmA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikg | DYE-DECOLORIZINGPEROXIDASE (Auriculariaauricula-judae) |
PF04261(Dyp_perox) | 4 | ILE A 143LEU A 73GLY A 72PHE A 68 | None | 0.95A | 5kmdC-5ikgA:undetectable5kmdD-5ikgA:undetectable | 5kmdC-5ikgA:19.365kmdD-5ikgA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j32 | 3-ISOPROPYLMALATEDEHYDROGENASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00180(Iso_dh) | 4 | TYR A 181ILE A 180LEU A 290GLY A 287 | IPM A 502 (-4.5A)NoneNoneNone | 0.79A | 5kmdC-5j32A:undetectable5kmdD-5j32A:undetectable | 5kmdC-5j32A:22.585kmdD-5j32A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0t | ALPHA-KETOGLUTARATE-DEPENDENT NON-HEMEIRON OXYGENASE EASH (Aspergillusjaponicus) |
PF05721(PhyH) | 4 | ILE A 227LEU A 158GLY A 223PHE A 224 | None | 0.95A | 5kmdC-5m0tA:undetectable5kmdD-5m0tA:undetectable | 5kmdC-5m0tA:21.605kmdD-5m0tA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msc | CARBOXYLIC ACIDREDUCTASE (Nocardiaiowensis) |
PF00501(AMP-binding) | 4 | ILE A 301LEU A 311GLY A 309PHE A 308 | None | 0.88A | 5kmdC-5mscA:undetectable5kmdD-5mscA:2.4 | 5kmdC-5mscA:13.485kmdD-5mscA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmi | CYTOCHROME B-C1COMPLEX SUBUNIT 1,MITOCHONDRIAL (Bos taurus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 4 | ILE A 241LEU A 248GLY A 426PHE A 425 | None | 0.97A | 5kmdC-5nmiA:undetectable5kmdD-5nmiA:undetectable | 5kmdC-5nmiA:18.755kmdD-5nmiA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5np9 | TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN TSAE (Bacillussubtilis) |
no annotation | 4 | ILE A 17LEU A 52GLY A 51PHE A 48 | None | 0.85A | 5kmdC-5np9A:undetectable5kmdD-5np9A:undetectable | 5kmdC-5np9A:14.295kmdD-5np9A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 4 | TYR B 180ILE B 186LEU B 91GLY B 92 | None | 0.84A | 5kmdC-5ovnB:undetectable5kmdD-5ovnB:undetectable | 5kmdC-5ovnB:13.575kmdD-5ovnB:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcx | CD81 ANTIGEN (Homo sapiens) |
PF00335(Tetraspannin) | 4 | ILE A 100LEU A 91GLY A 92PHE A 94 | NoneNoneYCM A 89 ( 3.3A)None | 0.92A | 5kmdC-5tcxA:4.75kmdD-5tcxA:1.0 | 5kmdC-5tcxA:20.695kmdD-5tcxA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj6 | HIGH CONDUCTANCECALCIUM-ACTIVATEDPOTASSIUM CHANNEL (Aplysiacalifornica) |
PF00520(Ion_trans)PF03493(BK_channel_a) | 4 | ILE A 297LEU A 245GLY A 289PHE A 292 | None | 0.95A | 5kmdC-5tj6A:8.05kmdD-5tj6A:5.5 | 5kmdC-5tj6A:14.695kmdD-5tj6A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vjy | DUTP PYROPHOSPHATASE (Naegleriafowleri) |
PF00692(dUTPase) | 4 | TYR A 37ILE A 104LEU A 90GLY A 91 | NoneNoneNoneBTB A 201 (-3.5A) | 0.87A | 5kmdC-5vjyA:undetectable5kmdD-5vjyA:undetectable | 5kmdC-5vjyA:18.825kmdD-5vjyA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vms | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILYKQT MEMBER 1 (Xenopus laevis) |
PF00520(Ion_trans)PF03520(KCNQ_channel) | 4 | ILE A 318LEU A 261GLY A 262PHE A 265 | None | 0.81A | 5kmdC-5vmsA:7.15kmdD-5vmsA:4.8 | 5kmdC-5vmsA:20.925kmdD-5vmsA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 4 | ILE A 397LEU A 388GLY A 389PHE A 391 | None | 0.94A | 5kmdC-5xsyA:12.85kmdD-5xsyA:11.9 | 5kmdC-5xsyA:10.025kmdD-5xsyA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y35 | - (-) |
no annotation | 4 | TYR B 26ILE B 136LEU B 98GLY B 97 | None | 0.95A | 5kmdC-5y35B:undetectable5kmdD-5y35B:undetectable | 5kmdC-5y35B:undetectable5kmdD-5y35B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yq7 | PRECURSOR FOR LSUBUNITS OFPHOTOSYNTHETICREACTION CENTER (Roseiflexuscastenholzii) |
no annotation | 4 | ILE L 105LEU L 82GLY L 83PHE L 86 | NoneNoneBPH L1003 ( 4.5A)None | 0.57A | 5kmdC-5yq7L:3.45kmdD-5yq7L:2.4 | 5kmdC-5yq7L:16.125kmdD-5yq7L:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a31 | PEPTIDYL-TRNAHYDROLASE (Acinetobacterbaumannii) |
no annotation | 4 | TYR A 83ILE A 85LEU A 40GLY A 51 | NoneNone NA A 201 (-4.3A)None | 0.88A | 5kmdC-6a31A:undetectable5kmdD-6a31A:undetectable | 5kmdC-6a31A:14.455kmdD-6a31A:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpz | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,MOUSEPIEZO1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | TYR A2470ILE A2473LEU A2208PHE A2209 | None | 0.89A | 5kmdC-6bpzA:2.95kmdD-6bpzA:2.7 | 5kmdC-6bpzA:15.385kmdD-6bpzA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cde | PGT122 HEAVY CHAIN (Homo sapiens) |
no annotation | 4 | TYR M 93ILE M 92LEU M 11GLY M 10 | None | 0.90A | 5kmdC-6cdeM:undetectable5kmdD-6cdeM:undetectable | 5kmdC-6cdeM:13.075kmdD-6cdeM:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMBH13 NADHDEHYDROGENASESUBUNIT (Pyrococcusfuriosus) |
no annotation | 4 | TYR M 14ILE M 236LEU I 18GLY I 17 | None | 0.88A | 5kmdC-6cfwM:undetectable5kmdD-6cfwM:undetectable | 5kmdC-6cfwM:16.495kmdD-6cfwM:16.49 |