SIMILAR PATTERNS OF AMINO ACIDS FOR 5KMD_C_6UBC1304_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE


(Acidithiobacillus
ferrooxidans)
PF00180
(Iso_dh)
4 TYR A 140
ILE A 139
LEU A 248
GLY A 245
IPM  A 401 (-4.5A)
None
None
None
0.76A 5kmdC-1a05A:
0.2
5kmdD-1a05A:
undetectable
5kmdC-1a05A:
21.49
5kmdD-1a05A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes)
PF00068
(Phospholip_A2_1)
4 TYR B  75
ILE B  82
LEU B   2
PHE B   5
None
None
None
ACT  B 134 (-4.6A)
0.91A 5kmdC-1aokB:
0.0
5kmdD-1aokB:
undetectable
5kmdC-1aokB:
14.04
5kmdD-1aokB:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE


(Pseudomonas
putida)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ILE A 380
LEU A 329
GLY A 327
PHE A 326
None
0.83A 5kmdC-1chmA:
0.0
5kmdD-1chmA:
0.0
5kmdC-1chmA:
21.98
5kmdD-1chmA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)


(Homo sapiens)
PF00168
(C2)
PF01735
(PLA2_B)
4 TYR A 275
ILE A 294
LEU A 303
GLY A 300
None
0.93A 5kmdC-1cjyA:
undetectable
5kmdD-1cjyA:
1.0
5kmdC-1cjyA:
18.44
5kmdD-1cjyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)


(Salmonella
enterica)
PF00180
(Iso_dh)
4 TYR A 145
ILE A 144
LEU A 253
GLY A 250
SO4  A 902 (-4.5A)
None
None
None
0.79A 5kmdC-1cnzA:
0.0
5kmdD-1cnzA:
undetectable
5kmdC-1cnzA:
19.89
5kmdD-1cnzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
4 ILE A 144
LEU A 238
GLY A 235
PHE A 216
None
0.84A 5kmdC-1dt2A:
undetectable
5kmdD-1dt2A:
undetectable
5kmdC-1dt2A:
22.22
5kmdD-1dt2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ILE A 216
LEU A 316
GLY A 269
PHE A 268
None
0.91A 5kmdC-1fotA:
2.6
5kmdD-1fotA:
1.8
5kmdC-1fotA:
20.66
5kmdD-1fotA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
4 TYR A  70
ILE A  77
LEU A   2
PHE A   5
None
0.92A 5kmdC-1g0zA:
0.5
5kmdD-1g0zA:
undetectable
5kmdC-1g0zA:
16.09
5kmdD-1g0zA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
4 TYR A 137
ILE A 136
LEU A 241
GLY A 238
None
0.85A 5kmdC-1idmA:
undetectable
5kmdD-1idmA:
undetectable
5kmdC-1idmA:
22.47
5kmdD-1idmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY


(Homo sapiens)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
4 TYR A 444
ILE A 462
GLY A 420
PHE A 421
None
0.93A 5kmdC-1jxkA:
undetectable
5kmdD-1jxkA:
undetectable
5kmdC-1jxkA:
18.18
5kmdD-1jxkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvl PPC DECARBOXYLASE
ATHAL3A


(Arabidopsis
thaliana)
PF02441
(Flavoprotein)
4 ILE A 189
LEU A  65
GLY A  36
PHE A  35
None
0.95A 5kmdC-1mvlA:
undetectable
5kmdD-1mvlA:
undetectable
5kmdC-1mvlA:
22.60
5kmdD-1mvlA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1


(Bos taurus)
PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N)
4 TYR A 216
ILE A 394
LEU A 167
GLY A 168
None
0.84A 5kmdC-1pztA:
undetectable
5kmdD-1pztA:
undetectable
5kmdC-1pztA:
19.57
5kmdD-1pztA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
4 ILE A  82
LEU A  89
GLY A  86
PHE A  85
None
0.96A 5kmdC-1sivA:
undetectable
5kmdD-1sivA:
undetectable
5kmdC-1sivA:
15.09
5kmdD-1sivA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE


(Escherichia
coli)
PF04262
(Glu_cys_ligase)
4 TYR A 326
ILE A 327
LEU A  26
GLY A  25
None
0.97A 5kmdC-1v4gA:
undetectable
5kmdD-1v4gA:
undetectable
5kmdC-1v4gA:
19.92
5kmdD-1v4gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpi PHOSPHOLIPASE A2
INHIBITOR


(Vipera
ammodytes)
PF00068
(Phospholip_A2_1)
4 TYR A  75
ILE A  82
LEU A   2
PHE A   5
None
0.94A 5kmdC-1vpiA:
0.1
5kmdD-1vpiA:
undetectable
5kmdC-1vpiA:
15.86
5kmdD-1vpiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE


(Penicillium
simplicissimum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
4 ILE A 265
LEU A 253
GLY A 252
PHE A 254
None
0.95A 5kmdC-1w1kA:
undetectable
5kmdD-1w1kA:
undetectable
5kmdC-1w1kA:
19.90
5kmdD-1w1kA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3b UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110


(Homo sapiens)
PF00515
(TPR_1)
PF13181
(TPR_8)
PF13414
(TPR_11)
PF13424
(TPR_12)
4 ILE A 197
LEU A 187
GLY A 188
PHE A 191
None
0.70A 5kmdC-1w3bA:
undetectable
5kmdD-1w3bA:
undetectable
5kmdC-1w3bA:
21.32
5kmdD-1w3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE


(Methylobacterium
extorquens)
PF08714
(Fae)
4 ILE A  26
LEU A  42
GLY A  41
PHE A  38
None
0.96A 5kmdC-1y60A:
undetectable
5kmdD-1y60A:
undetectable
5kmdC-1y60A:
21.14
5kmdD-1y60A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
4 TYR A  24
ILE A  23
LEU A 219
GLY A  53
None
None
None
CL  A 401 (-3.3A)
0.90A 5kmdC-1z47A:
undetectable
5kmdD-1z47A:
undetectable
5kmdC-1z47A:
21.56
5kmdD-1z47A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
4 TYR A 266
LEU A 222
GLY A 228
PHE A 253
None
0.73A 5kmdC-2ayuA:
undetectable
5kmdD-2ayuA:
undetectable
5kmdC-2ayuA:
19.01
5kmdD-2ayuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctr DNAJ HOMOLOG
SUBFAMILY B MEMBER 9


(Homo sapiens)
PF00226
(DnaJ)
4 TYR A  10
LEU A  71
GLY A  72
PHE A  76
None
0.90A 5kmdC-2ctrA:
2.1
5kmdD-2ctrA:
3.2
5kmdC-2ctrA:
13.50
5kmdD-2ctrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B


(Homo sapiens)
PF03416
(Peptidase_C54)
4 TYR A 265
ILE A 256
LEU A  87
PHE A  83
None
0.81A 5kmdC-2cy7A:
undetectable
5kmdD-2cy7A:
undetectable
5kmdC-2cy7A:
19.95
5kmdD-2cy7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 TYR A 162
ILE A 150
LEU A  67
GLY A  66
PHE A 105
None
1.35A 5kmdC-2g3nA:
undetectable
5kmdD-2g3nA:
undetectable
5kmdC-2g3nA:
18.91
5kmdD-2g3nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis)
PF00068
(Phospholip_A2_1)
4 TYR B  75
ILE B  82
LEU B   2
PHE B   5
None
0.79A 5kmdC-2h4cB:
undetectable
5kmdD-2h4cB:
undetectable
5kmdC-2h4cB:
14.29
5kmdD-2h4cB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum)
PF00296
(Bac_luciferase)
5 TYR A 330
ILE A 327
LEU A 287
GLY A 237
PHE A 238
None
1.43A 5kmdC-2i7gA:
undetectable
5kmdD-2i7gA:
undetectable
5kmdC-2i7gA:
20.93
5kmdD-2i7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus)
PF02585
(PIG-L)
4 ILE A   6
LEU A  39
GLY A  10
PHE A   9
None
0.92A 5kmdC-2ixdA:
undetectable
5kmdD-2ixdA:
undetectable
5kmdC-2ixdA:
21.57
5kmdD-2ixdA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE


(Acanthamoeba
polyphaga
mimivirus)
PF00579
(tRNA-synt_1b)
4 ILE A  67
LEU A  90
GLY A  91
PHE A  94
ILE  A  67 ( 0.7A)
LEU  A  90 ( 0.6A)
GLY  A  91 ( 0.0A)
PHE  A  94 ( 1.3A)
0.87A 5kmdC-2j5bA:
undetectable
5kmdD-2j5bA:
undetectable
5kmdC-2j5bA:
22.87
5kmdD-2j5bA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE


(Homo sapiens)
PF00764
(Arginosuc_synth)
4 TYR A 282
ILE A 266
LEU A  93
GLY A  90
None
0.72A 5kmdC-2nz2A:
undetectable
5kmdD-2nz2A:
undetectable
5kmdC-2nz2A:
21.36
5kmdD-2nz2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4t BH3976 PROTEIN

(Bacillus
halodurans)
PF06304
(DUF1048)
4 TYR A  31
ILE A  34
GLY A  58
PHE A  59
None
0.94A 5kmdC-2o4tA:
3.0
5kmdD-2o4tA:
undetectable
5kmdC-2o4tA:
15.22
5kmdD-2o4tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae)
PF00710
(Asparaginase)
4 TYR A 312
ILE A 208
LEU A 108
PHE A 105
None
0.90A 5kmdC-2ocdA:
undetectable
5kmdD-2ocdA:
undetectable
5kmdC-2ocdA:
21.53
5kmdD-2ocdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osn PHOSPHOLIPASE A2
ISOFORM 3


(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
4 TYR A  70
ILE A  77
LEU A   4
PHE A   7
None
0.90A 5kmdC-2osnA:
undetectable
5kmdD-2osnA:
undetectable
5kmdC-2osnA:
16.41
5kmdD-2osnA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]


(Haemophilus
influenzae)
PF02153
(PDH)
4 ILE A 103
LEU A 112
GLY A 113
PHE A 116
None
NAD  A 400 (-4.0A)
None
None
0.63A 5kmdC-2pv7A:
undetectable
5kmdD-2pv7A:
undetectable
5kmdC-2pv7A:
24.23
5kmdD-2pv7A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh5 MANNOSE-6-PHOSPHATE
ISOMERASE


(Helicobacter
pylori)
PF00483
(NTP_transferase)
4 ILE A 255
LEU A 260
GLY A 140
PHE A 139
None
0.92A 5kmdC-2qh5A:
undetectable
5kmdD-2qh5A:
undetectable
5kmdC-2qh5A:
23.05
5kmdD-2qh5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta)
PF00188
(CAP)
4 ILE A 147
LEU A 203
GLY A 204
PHE A 150
None
0.82A 5kmdC-2vznA:
undetectable
5kmdD-2vznA:
undetectable
5kmdC-2vznA:
18.82
5kmdD-2vznA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN


(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
4 TYR B1523
ILE B1547
LEU B1585
GLY B1584
None
0.95A 5kmdC-2xwbB:
undetectable
5kmdD-2xwbB:
1.6
5kmdC-2xwbB:
14.67
5kmdD-2xwbB:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
4 TYR A 266
LEU A 222
GLY A 228
PHE A 253
None
0.83A 5kmdC-2z2rA:
undetectable
5kmdD-2z2rA:
undetectable
5kmdC-2z2rA:
20.86
5kmdD-2z2rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE


(Escherichia
coli)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 TYR A 167
LEU A 157
GLY A 158
PHE A 161
None
None
GSH  A 290 (-3.4A)
None
0.93A 5kmdC-3c8eA:
2.4
5kmdD-3c8eA:
2.5
5kmdC-3c8eA:
22.57
5kmdD-3c8eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2


(Staphylococcus
aureus)
PF09383
(NIL)
4 TYR A 287
ILE A 289
GLY A 322
PHE A 321
None
0.70A 5kmdC-3cedA:
undetectable
5kmdD-3cedA:
undetectable
5kmdC-3cedA:
15.09
5kmdD-3cedA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN


(Bifidobacterium
adolescentis)
PF01168
(Ala_racemase_N)
4 ILE A 138
LEU A 101
GLY A 102
PHE A 117
None
0.93A 5kmdC-3cpgA:
undetectable
5kmdD-3cpgA:
undetectable
5kmdC-3cpgA:
18.58
5kmdD-3cpgA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)


(Salmonella
enterica)
PF09982
(DUF2219)
4 TYR A 287
ILE A 288
LEU A  37
GLY A  36
None
0.96A 5kmdC-3fidA:
undetectable
5kmdD-3fidA:
undetectable
5kmdC-3fidA:
21.16
5kmdD-3fidA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE


(Homo sapiens)
PF03747
(ADP_ribosyl_GH)
4 ILE A 277
LEU A  17
GLY A  18
PHE A 297
None
0.87A 5kmdC-3hfwA:
undetectable
5kmdD-3hfwA:
undetectable
5kmdC-3hfwA:
20.38
5kmdD-3hfwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE


(Brucella
melitensis)
PF02569
(Pantoate_ligase)
4 ILE A 170
LEU A  52
GLY A  25
PHE A  26
None
0.96A 5kmdC-3innA:
undetectable
5kmdD-3innA:
undetectable
5kmdC-3innA:
20.06
5kmdD-3innA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Homo sapiens)
PF03483
(B3_4)
PF03484
(B5)
4 TYR B 374
LEU B  33
GLY B  32
PHE B  31
None
0.89A 5kmdC-3l4gB:
undetectable
5kmdD-3l4gB:
undetectable
5kmdC-3l4gB:
18.84
5kmdD-3l4gB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
4 ILE A 179
LEU A 144
GLY A 145
PHE A 193
None
0.90A 5kmdC-3lk6A:
3.2
5kmdD-3lk6A:
2.3
5kmdC-3lk6A:
18.61
5kmdD-3lk6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE


(Burkholderia
pseudomallei)
PF00850
(Hist_deacetyl)
4 TYR A 320
LEU A 278
GLY A 279
PHE A 280
SO4  A 401 (-4.5A)
None
None
None
0.89A 5kmdC-3menA:
undetectable
5kmdD-3menA:
undetectable
5kmdC-3menA:
19.20
5kmdD-3menA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus)
PF05426
(Alginate_lyase)
4 TYR A 187
ILE A 184
LEU A 300
GLY A 301
None
None
None
EDO  A 412 (-3.5A)
0.91A 5kmdC-3nfvA:
undetectable
5kmdD-3nfvA:
undetectable
5kmdC-3nfvA:
20.05
5kmdD-3nfvA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2p PHOSPHOLIPASE A2

(Sus scrofa)
PF00068
(Phospholip_A2_1)
4 TYR A  75
ILE A  82
LEU A   2
PHE A   5
None
0.93A 5kmdC-3p2pA:
undetectable
5kmdD-3p2pA:
undetectable
5kmdC-3p2pA:
13.99
5kmdD-3p2pA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT


(Antirrhinum
majus)
no annotation 4 TYR B  20
ILE B  17
LEU B 120
GLY B 119
None
0.93A 5kmdC-3qkcB:
undetectable
5kmdD-3qkcB:
2.3
5kmdC-3qkcB:
20.82
5kmdD-3qkcB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2w TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY


(Methanosarcina
mazei)
PF01047
(MarR)
4 ILE A  25
LEU A 153
GLY A 152
PHE A 149
ILE  A  25 ( 0.7A)
LEU  A 153 ( 0.6A)
GLY  A 152 ( 0.0A)
PHE  A 149 ( 1.3A)
0.90A 5kmdC-3s2wA:
undetectable
5kmdD-3s2wA:
2.3
5kmdC-3s2wA:
17.02
5kmdD-3s2wA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3


(Mus musculus)
PF00069
(Pkinase)
4 ILE A 199
LEU A 302
GLY A 255
PHE A 254
None
0.85A 5kmdC-3ubdA:
undetectable
5kmdD-3ubdA:
1.4
5kmdC-3ubdA:
22.92
5kmdD-3ubdA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF00180
(Iso_dh)
4 TYR A 144
ILE A 143
LEU A 247
GLY A 244
None
0.93A 5kmdC-3uduA:
undetectable
5kmdD-3uduA:
undetectable
5kmdC-3uduA:
22.99
5kmdD-3uduA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes)
PF00089
(Trypsin)
4 ILE A 234
LEU A 108
GLY A  51
PHE A  52
None
0.94A 5kmdC-3ureA:
undetectable
5kmdD-3ureA:
undetectable
5kmdC-3ureA:
20.96
5kmdD-3ureA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
4 TYR A 450
ILE A 468
GLY A 426
PHE A 427
None
0.90A 5kmdC-3vm5A:
undetectable
5kmdD-3vm5A:
undetectable
5kmdC-3vm5A:
19.92
5kmdD-3vm5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta)
PF04261
(Dyp_perox)
4 ILE A 146
LEU A  76
GLY A  75
PHE A  71
None
0.92A 5kmdC-3vxiA:
undetectable
5kmdD-3vxiA:
undetectable
5kmdC-3vxiA:
20.99
5kmdD-3vxiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6x MPR1 PROTEIN

(Saccharomyces
cerevisiae)
no annotation 4 ILE A  69
LEU A  87
GLY A  85
PHE A  86
None
0.92A 5kmdC-3w6xA:
undetectable
5kmdD-3w6xA:
undetectable
5kmdC-3w6xA:
23.63
5kmdD-3w6xA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE


(Aspergillus
niger)
PF00150
(Cellulase)
4 ILE A 183
LEU A 208
GLY A 207
PHE A 226
None
0.95A 5kmdC-3wh9A:
undetectable
5kmdD-3wh9A:
undetectable
5kmdC-3wh9A:
18.56
5kmdD-3wh9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1


(Cyanidioschyzon
merolae)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 TYR A 163
LEU A 380
GLY A 143
PHE A 142
None
0.89A 5kmdC-3wmeA:
3.8
5kmdD-3wmeA:
4.2
5kmdC-3wmeA:
19.32
5kmdD-3wmeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x29 CLAUDIN-19

(Mus musculus)
PF00822
(PMP22_Claudin)
4 ILE A  21
LEU A 182
GLY A 179
PHE A 126
None
0.96A 5kmdC-3x29A:
undetectable
5kmdD-3x29A:
2.5
5kmdC-3x29A:
20.91
5kmdD-3x29A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 5 TYR A 468
ILE A 285
LEU A 464
GLY A 470
PHE A 466
None
1.23A 5kmdC-4bb9A:
5.5
5kmdD-4bb9A:
2.7
5kmdC-4bb9A:
17.98
5kmdD-4bb9A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8)
PF11602
(NTPase_P4)
4 ILE A  48
LEU A  59
GLY A  60
PHE A  61
None
0.95A 5kmdC-4blqA:
undetectable
5kmdD-4blqA:
undetectable
5kmdC-4blqA:
22.47
5kmdD-4blqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 TYR A 665
ILE A 680
LEU A 690
GLY A 689
None
0.95A 5kmdC-4czwA:
undetectable
5kmdD-4czwA:
undetectable
5kmdC-4czwA:
18.43
5kmdD-4czwA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 TYR A 231
ILE A 226
LEU A 179
GLY A 178
None
0.90A 5kmdC-4ewjA:
undetectable
5kmdD-4ewjA:
undetectable
5kmdC-4ewjA:
20.67
5kmdD-4ewjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
4 ILE A 836
LEU A 909
GLY A 908
PHE A 832
None
0.92A 5kmdC-4ifqA:
3.7
5kmdD-4ifqA:
3.8
5kmdC-4ifqA:
15.26
5kmdD-4ifqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00180
(Iso_dh)
4 TYR A 135
ILE A 134
LEU A 248
GLY A 245
None
0.87A 5kmdC-4iwhA:
undetectable
5kmdD-4iwhA:
undetectable
5kmdC-4iwhA:
19.33
5kmdD-4iwhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE


(Danio rerio)
no annotation 4 TYR E  34
LEU E 113
GLY E 110
PHE E  69
None
0.96A 5kmdC-4l95E:
undetectable
5kmdD-4l95E:
undetectable
5kmdC-4l95E:
22.26
5kmdD-4l95E:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
4 ILE A  34
LEU A 177
GLY A 178
PHE A 181
None
0.94A 5kmdC-4ljsA:
undetectable
5kmdD-4ljsA:
undetectable
5kmdC-4ljsA:
21.61
5kmdD-4ljsA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
PF16403
(DUF5011)
4 ILE A 264
LEU A 273
GLY A 272
PHE A 271
None
0.91A 5kmdC-4mb5A:
undetectable
5kmdD-4mb5A:
undetectable
5kmdC-4mb5A:
18.10
5kmdD-4mb5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE


(Streptococcus
sanguinis)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 TYR A 164
LEU A 154
GLY A 155
PHE A 158
None
None
GDS  A 301 (-3.3A)
None
0.93A 5kmdC-4mzwA:
2.3
5kmdD-4mzwA:
2.6
5kmdC-4mzwA:
22.91
5kmdD-4mzwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlm LMO1340 PROTEIN

(Listeria
monocytogenes)
no annotation 4 TYR A 206
ILE A 219
LEU A 202
GLY A 203
None
0.66A 5kmdC-4nlmA:
undetectable
5kmdD-4nlmA:
undetectable
5kmdC-4nlmA:
23.36
5kmdD-4nlmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli)
PF02395
(Peptidase_S6)
4 ILE A 343
LEU A 311
GLY A 315
PHE A 316
None
0.93A 5kmdC-4om9A:
undetectable
5kmdD-4om9A:
undetectable
5kmdC-4om9A:
16.37
5kmdD-4om9A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D


(Vibrio cholerae)
PF02508
(Rnf-Nqr)
4 ILE D 191
LEU D  16
GLY D 140
PHE D 143
None
0.76A 5kmdC-4p6vD:
undetectable
5kmdD-4p6vD:
1.6
5kmdC-4p6vD:
25.44
5kmdD-4p6vD:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF08774
(VRR_NUC)
4 TYR A  37
ILE A  33
GLY A 181
PHE A 180
None
0.93A 5kmdC-4r89A:
undetectable
5kmdD-4r89A:
undetectable
5kmdC-4r89A:
16.64
5kmdD-4r89A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ILE A 264
LEU A 273
GLY A 272
PHE A 271
None
0.92A 5kmdC-4w5zA:
undetectable
5kmdD-4w5zA:
undetectable
5kmdC-4w5zA:
20.55
5kmdD-4w5zA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwj TENA/THI-4 FAMILY
PROTEIN


(Pseudomonas
protegens)
PF14518
(Haem_oxygenas_2)
4 ILE A 208
LEU A 215
GLY A 214
PHE A   5
None
0.94A 5kmdC-4wwjA:
undetectable
5kmdD-4wwjA:
undetectable
5kmdC-4wwjA:
19.01
5kmdD-4wwjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
4 ILE A  64
LEU A 170
GLY A 189
PHE A 188
None
0.93A 5kmdC-4xk1A:
undetectable
5kmdD-4xk1A:
undetectable
5kmdC-4xk1A:
22.66
5kmdD-4xk1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN


(Pseudomonas
putida)
PF00753
(Lactamase_B)
4 ILE A 100
LEU A 110
GLY A 108
PHE A 107
None
0.95A 5kmdC-4yslA:
undetectable
5kmdD-4yslA:
undetectable
5kmdC-4yslA:
21.17
5kmdD-4yslA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi)
PF03702
(AnmK)
4 ILE A 110
LEU A  85
GLY A  86
PHE A  89
None
0.69A 5kmdC-4zxzA:
undetectable
5kmdD-4zxzA:
undetectable
5kmdC-4zxzA:
17.92
5kmdD-4zxzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC


(Neisseria
meningitidis)
PF02661
(Fic)
5 TYR A  48
ILE A  45
LEU A  53
GLY A  51
PHE A  50
None
1.48A 5kmdC-5cglA:
undetectable
5kmdD-5cglA:
undetectable
5kmdC-5cglA:
19.65
5kmdD-5cglA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ILE A 682
LEU A 469
GLY A 468
PHE A 465
None
0.96A 5kmdC-5chcA:
undetectable
5kmdD-5chcA:
undetectable
5kmdC-5chcA:
15.65
5kmdD-5chcA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN


(Danio rerio)
PF03318
(ETX_MTX2)
4 ILE A   9
LEU A  29
GLY A 125
PHE A 139
PEG  A 408 (-4.3A)
None
None
None
0.78A 5kmdC-5di0A:
undetectable
5kmdD-5di0A:
undetectable
5kmdC-5di0A:
24.66
5kmdD-5di0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwa TYPE-2 RESTRICTION
ENZYME AGEI


(Thalassobius
gelatinovorus)
no annotation 4 TYR A  31
ILE A  28
GLY A  48
PHE A  51
None
0.95A 5kmdC-5dwaA:
undetectable
5kmdD-5dwaA:
undetectable
5kmdC-5dwaA:
22.29
5kmdD-5dwaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
4 ILE A 330
LEU A 364
GLY A 362
PHE A 365
None
0.95A 5kmdC-5gnmA:
undetectable
5kmdD-5gnmA:
1.5
5kmdC-5gnmA:
20.48
5kmdD-5gnmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE


(Auricularia
auricula-judae)
PF04261
(Dyp_perox)
4 ILE A 143
LEU A  73
GLY A  72
PHE A  68
None
0.95A 5kmdC-5ikgA:
undetectable
5kmdD-5ikgA:
undetectable
5kmdC-5ikgA:
19.36
5kmdD-5ikgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00180
(Iso_dh)
4 TYR A 181
ILE A 180
LEU A 290
GLY A 287
IPM  A 502 (-4.5A)
None
None
None
0.79A 5kmdC-5j32A:
undetectable
5kmdD-5j32A:
undetectable
5kmdC-5j32A:
22.58
5kmdD-5j32A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH


(Aspergillus
japonicus)
PF05721
(PhyH)
4 ILE A 227
LEU A 158
GLY A 223
PHE A 224
None
0.95A 5kmdC-5m0tA:
undetectable
5kmdD-5m0tA:
undetectable
5kmdC-5m0tA:
21.60
5kmdD-5m0tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE


(Nocardia
iowensis)
PF00501
(AMP-binding)
4 ILE A 301
LEU A 311
GLY A 309
PHE A 308
None
0.88A 5kmdC-5mscA:
undetectable
5kmdD-5mscA:
2.4
5kmdC-5mscA:
13.48
5kmdD-5mscA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL


(Bos taurus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
4 ILE A 241
LEU A 248
GLY A 426
PHE A 425
None
0.97A 5kmdC-5nmiA:
undetectable
5kmdD-5nmiA:
undetectable
5kmdC-5nmiA:
18.75
5kmdD-5nmiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE


(Bacillus
subtilis)
no annotation 4 ILE A  17
LEU A  52
GLY A  51
PHE A  48
None
0.85A 5kmdC-5np9A:
undetectable
5kmdD-5np9A:
undetectable
5kmdC-5np9A:
14.29
5kmdD-5np9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus)
no annotation 4 TYR B 180
ILE B 186
LEU B  91
GLY B  92
None
0.84A 5kmdC-5ovnB:
undetectable
5kmdD-5ovnB:
undetectable
5kmdC-5ovnB:
13.57
5kmdD-5ovnB:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcx CD81 ANTIGEN

(Homo sapiens)
PF00335
(Tetraspannin)
4 ILE A 100
LEU A  91
GLY A  92
PHE A  94
None
None
YCM  A  89 ( 3.3A)
None
0.92A 5kmdC-5tcxA:
4.7
5kmdD-5tcxA:
1.0
5kmdC-5tcxA:
20.69
5kmdD-5tcxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL


(Aplysia
californica)
PF00520
(Ion_trans)
PF03493
(BK_channel_a)
4 ILE A 297
LEU A 245
GLY A 289
PHE A 292
None
0.95A 5kmdC-5tj6A:
8.0
5kmdD-5tj6A:
5.5
5kmdC-5tj6A:
14.69
5kmdD-5tj6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjy DUTP PYROPHOSPHATASE

(Naegleria
fowleri)
PF00692
(dUTPase)
4 TYR A  37
ILE A 104
LEU A  90
GLY A  91
None
None
None
BTB  A 201 (-3.5A)
0.87A 5kmdC-5vjyA:
undetectable
5kmdD-5vjyA:
undetectable
5kmdC-5vjyA:
18.82
5kmdD-5vjyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1


(Xenopus laevis)
PF00520
(Ion_trans)
PF03520
(KCNQ_channel)
4 ILE A 318
LEU A 261
GLY A 262
PHE A 265
None
0.81A 5kmdC-5vmsA:
7.1
5kmdD-5vmsA:
4.8
5kmdC-5vmsA:
20.92
5kmdD-5vmsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
4 ILE A 397
LEU A 388
GLY A 389
PHE A 391
None
0.94A 5kmdC-5xsyA:
12.8
5kmdD-5xsyA:
11.9
5kmdC-5xsyA:
10.02
5kmdD-5xsyA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-)
no annotation 4 TYR B  26
ILE B 136
LEU B  98
GLY B  97
None
0.95A 5kmdC-5y35B:
undetectable
5kmdD-5y35B:
undetectable
5kmdC-5y35B:
undetectable
5kmdD-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER


(Roseiflexus
castenholzii)
no annotation 4 ILE L 105
LEU L  82
GLY L  83
PHE L  86
None
None
BPH  L1003 ( 4.5A)
None
0.57A 5kmdC-5yq7L:
3.4
5kmdD-5yq7L:
2.4
5kmdC-5yq7L:
16.12
5kmdD-5yq7L:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE


(Acinetobacter
baumannii)
no annotation 4 TYR A  83
ILE A  85
LEU A  40
GLY A  51
None
None
NA  A 201 (-4.3A)
None
0.88A 5kmdC-6a31A:
undetectable
5kmdD-6a31A:
undetectable
5kmdC-6a31A:
14.45
5kmdD-6a31A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 4 TYR A2470
ILE A2473
LEU A2208
PHE A2209
None
0.89A 5kmdC-6bpzA:
2.9
5kmdD-6bpzA:
2.7
5kmdC-6bpzA:
15.38
5kmdD-6bpzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cde PGT122 HEAVY CHAIN

(Homo sapiens)
no annotation 4 TYR M  93
ILE M  92
LEU M  11
GLY M  10
None
0.90A 5kmdC-6cdeM:
undetectable
5kmdD-6cdeM:
undetectable
5kmdC-6cdeM:
13.07
5kmdD-6cdeM:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MBH13 NADH
DEHYDROGENASE
SUBUNIT


(Pyrococcus
furiosus)
no annotation 4 TYR M  14
ILE M 236
LEU I  18
GLY I  17
None
0.88A 5kmdC-6cfwM:
undetectable
5kmdD-6cfwM:
undetectable
5kmdC-6cfwM:
16.49
5kmdD-6cfwM:
16.49