SIMILAR PATTERNS OF AMINO ACIDS FOR 5KLA_A_ACTA1505_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		3 HIS A 304
LYS A 300
PHE A 328
 HIS  A 304 ( 1.0A)
LYS  A 300 ( 0.0A)
PHE  A 328 ( 1.3A)
 1.45A 5klaA-1aoaA:
undetectable		 5klaA-1aoaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk8 ANTIMICROBIAL
PROTEIN 1

(Aesculus
hippocastanum) 		PF00304
(Gamma-thionin) 		3 HIS A  36
LYS A  43
PHE A  45
 None
 1.30A 5klaA-1bk8A:
undetectable		 5klaA-1bk8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8k GENERAL
TRANSCRIPTION FACTOR
TFIIE-BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		3 HIS A  24
LYS A  21
PHE A  74
 None
 1.20A 5klaA-1d8kA:
undetectable		 5klaA-1d8kA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		3 HIS A 585
LYS A 582
PHE A 432
 None
 1.07A 5klaA-1dotA:
undetectable		 5klaA-1dotA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A  41
LYS A 119
PHE A 142
 None
 0.99A 5klaA-1eqwA:
undetectable		 5klaA-1eqwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 HIS A 435
LYS A 432
PHE A 464
 None
 1.48A 5klaA-1ftsA:
undetectable		 5klaA-1ftsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		3 HIS A 130
LYS A  92
PHE A  90
 None
 1.43A 5klaA-1iuhA:
undetectable		 5klaA-1iuhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 HIS A 134
LYS A 270
PHE A 223
 None
 1.27A 5klaA-1lwdA:
0.4		 5klaA-1lwdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		3 HIS A 244
LYS A   5
PHE A   7
 None
 1.20A 5klaA-1mtpA:
undetectable		 5klaA-1mtpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		3 HIS A 262
LYS A   1
PHE A 255
 None
 1.25A 5klaA-1ne7A:
0.0		 5klaA-1ne7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		3 HIS A 145
LYS A 142
PHE A  29
 None
 1.32A 5klaA-1o6dA:
undetectable		 5klaA-1o6dA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 HIS A 475
LYS A 458
PHE A 414
 None
 1.40A 5klaA-1pbyA:
0.0		 5klaA-1pbyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1u FIBROBLAST GROWTH
FACTOR HOMOLOGOUS
FACTOR 1

(Homo sapiens) 		PF00167
(FGF) 		3 HIS A 135
LYS A 129
PHE A  90
 None
 1.49A 5klaA-1q1uA:
undetectable		 5klaA-1q1uA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc3 GLOBIN

(Lampetra
fluviatilis) 		PF00042
(Globin) 		3 HIS A 105
LYS A 104
PHE A 109
 HEM  A 150 (-3.6A)
HEM  A 150 (-2.9A)
HEM  A 150 (-3.4A)
 1.47A 5klaA-1uc3A:
undetectable		 5klaA-1uc3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 HIS A 103
LYS A  60
PHE A 166
 None
 1.42A 5klaA-1uwyA:
undetectable		 5klaA-1uwyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 HIS A 268
LYS A 270
PHE A 152
 None
 1.49A 5klaA-1vqvA:
undetectable		 5klaA-1vqvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x63 SKELETAL MUSCLE
LIM-PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		3 HIS A  71
LYS A  74
PHE A  75
 None
 1.18A 5klaA-1x63A:
undetectable		 5klaA-1x63A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 HIS A 577
LYS A 585
PHE A 587
 None
 1.00A 5klaA-1x9nA:
undetectable		 5klaA-1x9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe7 HYPOTHETICAL 22.5
KDA PROTEIN IN
TUB1-CPR3 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF06172
(Cupin_5) 		3 HIS A 202
LYS A 180
PHE A 178
 None
 1.08A 5klaA-1xe7A:
undetectable		 5klaA-1xe7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zw8 ZINC-RESPONSIVE
TRANSCRIPTIONAL
REGULATOR ZAP1

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A  35
LYS A  34
PHE A  33
 None
 1.08A 5klaA-1zw8A:
undetectable		 5klaA-1zw8A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C

(Wolinella
succinogenes) 		PF01127
(Sdh_cyt) 		3 HIS C 114
LYS C 115
PHE C 111
 None
 1.28A 5klaA-2bs4C:
undetectable		 5klaA-2bs4C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 HIS A  88
LYS A  90
PHE A  91
 FAD  A 271 (-4.0A)
None
FAD  A 271 (-3.5A)
 1.14A 5klaA-2cndA:
undetectable		 5klaA-2cndA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		3 HIS A  10
LYS A  13
PHE A  14
 None
 1.15A 5klaA-2ghiA:
undetectable		 5klaA-2ghiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9a E3 UBIQUITIN-PROTEIN
LIGASE ZFP91

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 HIS A  64
LYS A  63
PHE A  69
 ZN  A 102 (-3.3A)
None
None
 0.67A 5klaA-2m9aA:
undetectable		 5klaA-2m9aA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mrp DNA DAMAGE-INDUCIBLE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A  43
LYS A  40
PHE A  38
 None
 1.22A 5klaA-2mrpA:
undetectable		 5klaA-2mrpA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqd CHAGASIN

(Trypanosoma
cruzi) 		PF09394
(Inhibitor_I42) 		3 HIS A  72
LYS A  56
PHE A  58
 None
 1.42A 5klaA-2nqdA:
undetectable		 5klaA-2nqdA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 HIS A 104
LYS A  60
PHE A 189
 None
 1.47A 5klaA-2nsmA:
undetectable		 5klaA-2nsmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		3 HIS A 285
LYS A 189
PHE A 261
 None
 1.24A 5klaA-2psfA:
undetectable		 5klaA-2psfA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 HIS A 112
LYS A 140
PHE A 142
 ZN  A 700 (-3.3A)
ACY  A 800 (-4.3A)
None
 0.78A 5klaA-2q42A:
undetectable		 5klaA-2q42A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		3 HIS A 134
LYS A 272
PHE A 225
 None
 1.27A 5klaA-2qfvA:
undetectable		 5klaA-2qfvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE

(Francisella
tularensis) 		no annotation 3 HIS B  15
LYS B  16
PHE B 136
 None
 1.32A 5klaA-2qjtB:
undetectable		 5klaA-2qjtB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		3 HIS A 144
LYS A 141
PHE A 291
 None
 1.12A 5klaA-2qsfA:
undetectable		 5klaA-2qsfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		3 HIS A  88
LYS A  83
PHE A 161
 None
 0.64A 5klaA-2qzcA:
undetectable		 5klaA-2qzcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt9 NICOTINAMIDASE

(Acinetobacter
baumannii) 		PF00857
(Isochorismatase) 		3 HIS A  89
LYS A  88
PHE A  63
 ZN  A1212 ( 3.5A)
None
None
 1.32A 5klaA-2wt9A:
undetectable		 5klaA-2wt9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 HIS A 108
LYS A  45
PHE A  43
 None
 1.27A 5klaA-2ylkA:
undetectable		 5klaA-2ylkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a30 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF05257
(CHAP) 		3 HIS A  55
LYS A  56
PHE A  44
 None
 1.39A 5klaA-3a30A:
undetectable		 5klaA-3a30A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		3 HIS A  73
LYS A  76
PHE A  77
 None
 1.17A 5klaA-3a6pA:
4.1		 5klaA-3a6pA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		3 HIS A 221
LYS A 220
PHE A 345
 None
PLP  A 500 (-1.3A)
None
 1.39A 5klaA-3bb8A:
undetectable		 5klaA-3bb8A:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		3 HIS A1075
LYS A1076
PHE A1077
 None
G  C   3 ( 3.7A)
U  C   4 ( 4.4A)
 0.58A 5klaA-3bsxA:
41.6		 5klaA-3bsxA:
78.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		3 HIS A 795
LYS A 796
PHE A 797
 None
 1.43A 5klaA-3bwtA:
33.0		 5klaA-3bwtA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		3 HIS A 248
LYS A 252
PHE A 222
 None
 1.21A 5klaA-3c7oA:
undetectable		 5klaA-3c7oA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2

(Schizosaccharomyces
pombe) 		PF04045
(P34-Arc) 		3 HIS D 272
LYS D   1
PHE D 271
 None
 1.40A 5klaA-3dwlD:
undetectable		 5klaA-3dwlD:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 HIS B 274
LYS B 278
PHE B 279
 None
 1.27A 5klaA-3jcmB:
undetectable		 5klaA-3jcmB:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		3 HIS A 771
LYS A 772
PHE A 773
 None
G  B   4 ( 3.0A)
U  B   5 ( 4.4A)
 0.50A 5klaA-3k49A:
36.9		 5klaA-3k49A:
46.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1

(Homo sapiens) 		PF14429
(DOCK-C2) 		3 HIS A 508
LYS A 535
PHE A 533
 None
 1.49A 5klaA-3l4cA:
undetectable		 5klaA-3l4cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 HIS A  79
LYS A  76
PHE A  78
 None
CIT  A   1 (-2.9A)
None
 0.93A 5klaA-3lmzA:
undetectable		 5klaA-3lmzA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON
COATOMER SUBUNIT
ALPHA

(Bos taurus;
Bos taurus) 		PF04733
(Coatomer_E)
PF06957
(COPI_C) 		3 HIS A 141
LYS B 905
PHE B 906
 None
 1.28A 5klaA-3mkrA:
3.4		 5klaA-3mkrA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 HIS A 339
LYS A 342
PHE A 343
 None
 1.22A 5klaA-3n92A:
undetectable		 5klaA-3n92A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 HIS A  55
LYS A  56
PHE A  44
 None
 1.43A 5klaA-3o98A:
undetectable		 5klaA-3o98A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 HIS A 366
LYS A 361
PHE A 230
 None
 1.38A 5klaA-3qlvA:
undetectable		 5klaA-3qlvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		3 HIS A 133
LYS A 268
PHE A 221
 None
 1.23A 5klaA-3us8A:
undetectable		 5klaA-3us8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF16804
(DUF5071) 		3 HIS A  11
LYS A  12
PHE A  13
 None
 1.09A 5klaA-3ut7A:
2.4		 5klaA-3ut7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9p THYMIDYLATE KINASE

(Burkholderia
thailandensis) 		PF02223
(Thymidylate_kin) 		3 HIS A  20
LYS A  17
PHE A 137
 None
 1.50A 5klaA-3v9pA:
undetectable		 5klaA-3v9pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 HIS A4622
LYS A4620
PHE A4679
 None
 1.37A 5klaA-3vkgA:
undetectable		 5klaA-3vkgA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw4 REP

(Escherichia
coli) 		PF08708
(PriCT_1) 		3 HIS A 237
LYS A 234
PHE A 198
 None
 1.44A 5klaA-3vw4A:
undetectable		 5klaA-3vw4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 HIS A 282
LYS A 289
PHE A 291
 None
 1.40A 5klaA-3w1gA:
undetectable		 5klaA-3w1gA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 HIS A 117
LYS A 114
PHE A 116
 None
 1.43A 5klaA-3wv4A:
undetectable		 5klaA-3wv4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 3 HIS A  41
LYS A  40
PHE A  17
 None
 1.24A 5klaA-3zbqA:
undetectable		 5klaA-3zbqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 HIS A 536
LYS A 537
PHE A 533
 None
 1.22A 5klaA-4a4zA:
undetectable		 5klaA-4a4zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		3 HIS A  88
LYS A  87
PHE A 241
 None
 1.39A 5klaA-4a5zA:
undetectable		 5klaA-4a5zA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		3 HIS A 406
LYS A 405
PHE A 410
 None
 0.61A 5klaA-4akvA:
undetectable		 5klaA-4akvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		3 HIS A 132
LYS A 267
PHE A 220
 None
 1.25A 5klaA-4aovA:
undetectable		 5klaA-4aovA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 HIS A  73
LYS A  75
PHE A 104
 None
 1.48A 5klaA-4f0jA:
undetectable		 5klaA-4f0jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 HIS A 255
LYS A 254
PHE A 259
 None
 1.43A 5klaA-4f7gA:
undetectable		 5klaA-4f7gA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go6 HCF C-TERMINAL CHAIN
1

(Homo sapiens) 		no annotation 3 HIS B1827
LYS B1852
PHE B1829
 None
 1.16A 5klaA-4go6B:
undetectable		 5klaA-4go6B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 HIS C 895
LYS C 894
PHE C 849
 None
 1.39A 5klaA-4hb4C:
2.4		 5klaA-4hb4C:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		3 HIS A 136
LYS A 273
PHE A 226
 None
 1.21A 5klaA-4hcxA:
undetectable		 5klaA-4hcxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		3 HIS A 209
LYS A 206
PHE A 240
 None
 1.45A 5klaA-4i4iA:
undetectable		 5klaA-4i4iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		3 HIS B 349
LYS B 325
PHE B 321
 None
 1.12A 5klaA-4iyoB:
undetectable		 5klaA-4iyoB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN

(Escherichia
virus T5) 		no annotation 3 HIS A 132
LYS A 134
PHE A 157
 None
 0.91A 5klaA-4jmqA:
undetectable		 5klaA-4jmqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		3 HIS A  20
LYS A  21
PHE A 228
 None
 1.48A 5klaA-4jn6A:
undetectable		 5klaA-4jn6A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 HIS L 198
LYS L 142
PHE L 139
 None
 1.49A 5klaA-4k2uL:
undetectable		 5klaA-4k2uL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 3 HIS A 225
LYS A 224
PHE A   2
 None
 1.03A 5klaA-4lypA:
undetectable		 5klaA-4lypA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlk CT584 PROTEIN

(Chlamydia
trachomatis) 		PF17435
(DUF5414) 		3 HIS A  95
LYS A  92
PHE A  35
 None
 1.22A 5klaA-4mlkA:
undetectable		 5klaA-4mlkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		3 HIS A  60
LYS A  27
PHE A  29
 None
 1.49A 5klaA-4pafA:
undetectable		 5klaA-4pafA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		3 HIS B 670
LYS B 624
PHE B 616
 None
 1.34A 5klaA-4wvmB:
undetectable		 5klaA-4wvmB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		3 HIS A 353
LYS A 351
PHE A 378
 None
 1.11A 5klaA-4x7mA:
undetectable		 5klaA-4x7mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xba APRATAXIN-LIKE
PROTEIN

(Schizosaccharomyces
pombe) 		PF01230
(HIT)
PF16278
(zf-C2HE) 		3 HIS A 155
LYS A  67
PHE A 169
 None
GMP  A 301 (-2.9A)
None
 1.18A 5klaA-4xbaA:
undetectable		 5klaA-4xbaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		3 HIS A 825
LYS A 824
PHE A 962
 None
 1.00A 5klaA-4z7gA:
undetectable		 5klaA-4z7gA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		3 HIS A 311
LYS A 259
PHE A 313
 None
 1.41A 5klaA-4zzyA:
undetectable		 5klaA-4zzyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 3 HIS A 150
LYS A 153
PHE A 154
 ZN  A1455 (-3.3A)
None
None
 1.24A 5klaA-5ah1A:
undetectable		 5klaA-5ah1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b23 UNCHARACTERIZED
PROTEIN SORTASE B

(Clostridium
perfringens) 		PF04203
(Sortase) 		3 HIS A 105
LYS A 109
PHE A 101
 None
 1.37A 5klaA-5b23A:
undetectable		 5klaA-5b23A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		3 HIS A  36
LYS A  33
PHE A  75
 None
 1.46A 5klaA-5frsA:
3.1		 5klaA-5frsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1d RHO GDP-DISSOCIATION
INHIBITOR 2

(Homo sapiens) 		PF02115
(Rho_GDI) 		3 HIS A 128
LYS A 175
PHE A 177
 None
 1.38A 5klaA-5h1dA:
undetectable		 5klaA-5h1dA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		3 HIS A 248
LYS A 243
PHE A 247
 None
 1.28A 5klaA-5ifmA:
undetectable		 5klaA-5ifmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		3 HIS A 219
LYS A 182
PHE A 180
 MLI  A 301 (-4.0A)
None
None
 1.37A 5klaA-5jj2A:
undetectable		 5klaA-5jj2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Oryctolagus
cuniculus) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		3 HIS P  11
LYS P  12
PHE P  13
 None
 1.36A 5klaA-5k0yP:
undetectable		 5klaA-5k0yP:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 3 HIS B 805
LYS B 438
PHE B 440
 None
 1.33A 5klaA-5khnB:
undetectable		 5klaA-5khnB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		3 HIS A 165
LYS A 173
PHE A 175
 None
 1.34A 5klaA-5l7kA:
undetectable		 5klaA-5l7kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE

(Pseudomonas
mendocina) 		PF11927
(DUF3445) 		3 HIS A 194
LYS A 191
PHE A 190
 HEM  A 501 (-3.2A)
None
HEM  A 501 (-4.8A)
 0.98A 5klaA-5ltiA:
undetectable		 5klaA-5ltiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 HIS A  21
LYS A  22
PHE A  18
 None
 1.07A 5klaA-5sujA:
undetectable		 5klaA-5sujA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 HIS A1569
LYS A1570
PHE A1566
 None
 1.23A 5klaA-5t8vA:
4.1		 5klaA-5t8vA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 HIS A 819
LYS A 812
PHE A 810
 None
 1.50A 5klaA-5um6A:
undetectable		 5klaA-5um6A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 3 HIS A 608
LYS A 696
PHE A 694
 None
 1.45A 5klaA-5winA:
undetectable		 5klaA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpb HISTONE DEACETYLASE
6

(Homo sapiens) 		PF02148
(zf-UBP) 		3 HIS A1203
LYS A1206
PHE A1207
 None
 1.24A 5klaA-5wpbA:
undetectable		 5klaA-5wpbA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 3 HIS A 146
LYS A 148
PHE A 125
 None
 1.35A 5klaA-5wpwA:
undetectable		 5klaA-5wpwA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 3 HIS C 271
LYS C 217
PHE C 213
 None
 1.35A 5klaA-6c08C:
undetectable		 5klaA-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 3 HIS A 263
LYS A 262
PHE A 266
 None
 1.31A 5klaA-6cv9A:
2.0		 5klaA-6cv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 3 HIS A 637
LYS A 635
PHE A  24
 None
 1.43A 5klaA-6eoqA:
undetectable		 5klaA-6eoqA:
undetectable