SIMILAR PATTERNS OF AMINO ACIDS FOR 5KKZ_K_ASCK1004_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgr | CANAVALINCANAVALIN (Canavaliaensiformis;Canavaliaensiformis) |
no annotationno annotation | 4 | ILE Y 348VAL X 304ARG Y 376HIS X 297 | PO4 X1500 ( 4.2A)PO4 X1500 ( 4.8A)PO4 X1500 (-3.7A)PO4 X1500 (-4.1A) | 1.21A | 5kkzK-1dgrY:undetectable5kkzQ-1dgrY:0.0 | 5kkzK-1dgrY:12.345kkzQ-1dgrY:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ee0 | 2-PYRONE SYNTHASE (Gerbera hybridcultivar) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | HIS A 308ILE A 350VAL A 307ARG A 333 | None | 1.10A | 5kkzK-1ee0A:undetectable5kkzQ-1ee0A:0.0 | 5kkzK-1ee0A:21.685kkzQ-1ee0A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzc | ERYTHRINACRISTA-GALLI LECTIN (Erythrinacrista-galli) |
PF00139(Lectin_legB) | 4 | ILE A 197VAL A 198TYR A 172GLN A 202 | None | 1.00A | 5kkzK-1gzcA:undetectable5kkzQ-1gzcA:0.7 | 5kkzK-1gzcA:20.185kkzQ-1gzcA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhc | MHC CLASS I ANTIGENH2-M3 (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 4 | VAL A 67TYR A 22GLN A 34HIS A 9 | None | 1.07A | 5kkzK-1mhcA:undetectable5kkzQ-1mhcA:0.5 | 5kkzK-1mhcA:19.035kkzQ-1mhcA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o70 | FASCICLIN I (Drosophilamelanogaster) |
PF02469(Fasciclin) | 4 | HIS A 610ILE A 612VAL A 611HIS A 543 | None | 1.08A | 5kkzK-1o70A:undetectable5kkzQ-1o70A:0.0 | 5kkzK-1o70A:21.935kkzQ-1o70A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urt | CARBONIC ANHYDRASE V (Mus musculus) |
PF00194(Carb_anhydrase) | 4 | HIS A 119ILE A 144TYR A 51HIS A 122 | ZN A 280 (-3.2A)NoneNoneNone | 1.27A | 5kkzK-1urtA:undetectable5kkzQ-1urtA:0.0 | 5kkzK-1urtA:21.035kkzQ-1urtA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4u | CHAPERONE PROTEINHTPG (Escherichiacoli) |
PF00183(HSP90)PF02518(HATPase_c) | 4 | ILE A 455VAL A 457TYR A 419GLN A 481 | None | 1.00A | 5kkzK-1y4uA:undetectable5kkzQ-1y4uA:0.0 | 5kkzK-1y4uA:21.615kkzQ-1y4uA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yj8 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 4 | HIS A 331ILE A 333VAL A 329GLN A 150 | None | 1.13A | 5kkzK-1yj8A:undetectable5kkzQ-1yj8A:0.0 | 5kkzK-1yj8A:21.705kkzQ-1yj8A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z26 | ARGONAUTE (Pyrococcusfuriosus) |
PF02171(Piwi)PF12212(PAZ_siRNAbind) | 4 | ILE A 145VAL A 128ARG A 111GLN A 148 | WO4 A 773 (-3.8A)NoneNoneNone | 1.19A | 5kkzK-1z26A:undetectable5kkzQ-1z26A:undetectable | 5kkzK-1z26A:18.895kkzQ-1z26A:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zao | RIO2 SERINE KINASE (Archaeoglobusfulgidus) |
PF01163(RIO1)PF09202(Rio2_N) | 4 | HIS A 216ILE A 214VAL A 215GLN A 238 | None | 0.91A | 5kkzK-1zaoA:undetectable5kkzQ-1zaoA:undetectable | 5kkzK-1zaoA:20.625kkzQ-1zaoA:20.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 5 | HIS C 291ILE C 292VAL C 293TYR C 302ARG C 306 | NoneSMA C 503 ( 4.5A)NoneSMA C 503 (-4.2A)None | 0.93A | 5kkzK-1zrtC:54.35kkzQ-1zrtC:undetectable | 5kkzK-1zrtC:82.475kkzQ-1zrtC:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5h | L-LYSINE2,3-AMINOMUTASE (Clostridiumsubterminale) |
PF04055(Radical_SAM)PF12544(LAM_C) | 4 | HIS A 230VAL A 206TYR A 62GLN A 79 | SAM A 417 ( 3.6A)NoneNoneNone | 1.14A | 5kkzK-2a5hA:undetectable5kkzQ-2a5hA:undetectable | 5kkzK-2a5hA:21.965kkzQ-2a5hA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a6p | POSSIBLEPHOSPHOGLYCERATEMUTASE GPM2 (Mycobacteriumtuberculosis) |
PF00300(His_Phos_1) | 4 | ILE A 58VAL A 57ARG A 140HIS A 136 | None | 1.21A | 5kkzK-2a6pA:undetectable5kkzQ-2a6pA:undetectable | 5kkzK-2a6pA:18.885kkzQ-2a6pA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi0 | HYPOTHETICAL PROTEINRV0216 (Mycobacteriumtuberculosis) |
no annotation | 4 | HIS A 252ILE A 254TYR A 94HIS A 279 | None | 1.24A | 5kkzK-2bi0A:undetectable5kkzQ-2bi0A:undetectable | 5kkzK-2bi0A:22.805kkzQ-2bi0A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bun | APPA (Rhodobactersphaeroides) |
PF04940(BLUF) | 4 | HIS A 68VAL A 72GLN A 49HIS A 44 | NoneNoneNoneFAD A1126 (-3.3A) | 1.24A | 5kkzK-2bunA:undetectable5kkzQ-2bunA:undetectable | 5kkzK-2bunA:15.445kkzQ-2bunA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cav | PROTEIN (CANAVALIN) (Canavaliaensiformis) |
PF00190(Cupin_1) | 4 | ILE A 348VAL A 304ARG A 376HIS A 297 | None | 1.19A | 5kkzK-2cavA:undetectable5kkzQ-2cavA:0.9 | 5kkzK-2cavA:19.885kkzQ-2cavA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | HIS A 560ILE A 493VAL A 494ARG A 576 | None | 1.27A | 5kkzK-2db3A:undetectable5kkzQ-2db3A:undetectable | 5kkzK-2db3A:20.705kkzQ-2db3A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dtc | RAL GUANINENUCLEOTIDE EXCHANGEFACTOR RALGPS1A (Mus musculus) |
PF00169(PH) | 4 | ILE A 62VAL A 60TYR A 38ARG A 9 | None | 0.86A | 5kkzK-2dtcA:undetectable5kkzQ-2dtcA:undetectable | 5kkzK-2dtcA:12.935kkzQ-2dtcA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmr | FMR1 PROTEIN (Homo sapiens) |
PF00013(KH_1) | 4 | HIS A 5ILE A 49VAL A 57ARG A 61 | None | 1.00A | 5kkzK-2fmrA:undetectable5kkzQ-2fmrA:undetectable | 5kkzK-2fmrA:10.875kkzQ-2fmrA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2it4 | CARBONIC ANHYDRASE 1 (Homo sapiens) |
PF00194(Carb_anhydrase) | 4 | HIS A 119ILE A 144TYR A 51HIS A 122 | ZN A 561 ( 3.1A)NoneNoneNone | 1.22A | 5kkzK-2it4A:undetectable5kkzQ-2it4A:undetectable | 5kkzK-2it4A:21.255kkzQ-2it4A:20.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qjp | CYTOCHROME B (Rhodobactersphaeroides) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 5 | HIS A 291ILE A 292VAL A 293TYR A 302ARG A 306 | NoneSMA A 1 ( 4.7A)NoneSMA A 1 (-4.4A)None | 0.47A | 5kkzK-2qjpA:61.15kkzQ-2qjpA:undetectable | 5kkzK-2qjpA:100.005kkzQ-2qjpA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qsf | DNA REPAIR PROTEINRAD4 (Saccharomycescerevisiae) |
PF03835(Rad4)PF10403(BHD_1)PF10405(BHD_3) | 4 | HIS A 344VAL A 341TYR A 424GLN A 381 | None | 1.23A | 5kkzK-2qsfA:undetectable5kkzQ-2qsfA:0.0 | 5kkzK-2qsfA:22.185kkzQ-2qsfA:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vg9 | BIFUNCTIONALENDO-1,4-BETA-XYLANASE A (Neocallimastixpatriciarum) |
PF00457(Glyco_hydro_11) | 4 | ILE A 149TYR A 96ARG A 56GLN A 11 | None | 1.29A | 5kkzK-2vg9A:undetectable5kkzQ-2vg9A:undetectable | 5kkzK-2vg9A:18.065kkzQ-2vg9A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w57 | FERRIC UPTAKEREGULATION PROTEIN (Vibrio cholerae) |
PF01475(FUR) | 4 | HIS A 88ILE A 100VAL A 99GLN A 32 | ZN A 202 (-3.2A)NoneNoneNone | 1.02A | 5kkzK-2w57A:undetectable5kkzQ-2w57A:undetectable | 5kkzK-2w57A:15.685kkzQ-2w57A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb7 | PT26-6P (Thermococcussp. 26-2) |
no annotation | 4 | HIS A 499TYR A 400GLN A 650HIS A 421 | None | 1.15A | 5kkzK-2wb7A:2.55kkzQ-2wb7A:undetectable | 5kkzK-2wb7A:21.635kkzQ-2wb7A:15.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2yiu | CYTOCHROME B (Paracoccusdenitrificans) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 5 | HIS A 291ILE A 292VAL A 293TYR A 302ARG A 306 | NoneSMA A 502 (-4.6A)NoneSMA A 502 (-4.5A)None | 0.42A | 5kkzK-2yiuA:60.85kkzQ-2yiuA:undetectable | 5kkzK-2yiuA:83.375kkzQ-2yiuA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6k | REPLICATION PROTEINA 32 KDA SUBUNIT (Homo sapiens) |
PF08784(RPA_C) | 4 | HIS A 45ILE A 46GLN A 44HIS A 131 | None | 1.28A | 5kkzK-2z6kA:undetectable5kkzQ-2z6kA:undetectable | 5kkzK-2z6kA:19.645kkzQ-2z6kA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zq5 | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
PF13469(Sulfotransfer_3) | 4 | HIS A 108ILE A 94TYR A 332HIS A 117 | None | 1.26A | 5kkzK-2zq5A:undetectable5kkzQ-2zq5A:undetectable | 5kkzK-2zq5A:22.885kkzQ-2zq5A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7o | ENDO-1,4-BETA-XYLANASE (Bacillussubtilis) |
PF03422(CBM_6)PF04616(Glyco_hydro_43) | 4 | ILE A 65VAL A 64GLN A 384HIS A 20 | None | 1.27A | 5kkzK-3c7oA:undetectable5kkzQ-3c7oA:0.8 | 5kkzK-3c7oA:22.035kkzQ-3c7oA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed0 | (3R)-HYDROXYMYRISTOYL-ACYL CARRIERPROTEIN DEHYDRATASE (Helicobacterpylori) |
PF07977(FabA) | 4 | HIS A 16ILE A 14ARG A 24GLN A 19 | None | 1.09A | 5kkzK-3ed0A:undetectable5kkzQ-3ed0A:undetectable | 5kkzK-3ed0A:16.075kkzQ-3ed0A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gm8 | GLYCOSIDE HYDROLASEFAMILY 2, CANDIDATEBETA-GLYCOSIDASE (Bacteroidesvulgatus) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | HIS A 152VAL A 150TYR A 86HIS A 57 | None | 1.18A | 5kkzK-3gm8A:undetectable5kkzQ-3gm8A:undetectable | 5kkzK-3gm8A:18.875kkzQ-3gm8A:13.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h1l | CYTOCHROME B (Gallus gallus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 4 | HIS C 268ILE C 269TYR C 279ARG C 283 | NoneNone3H1 C2001 (-4.2A)None | 0.91A | 5kkzK-3h1lC:48.35kkzQ-3h1lC:undetectable | 5kkzK-3h1lC:44.825kkzQ-3h1lC:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hr4 | NITRIC OXIDESYNTHASE, INDUCIBLE (Homo sapiens) |
PF00258(Flavodoxin_1) | 4 | HIS A 639VAL A 623TYR A 621GLN A 643 | None | 1.27A | 5kkzK-3hr4A:undetectable5kkzQ-3hr4A:undetectable | 5kkzK-3hr4A:18.205kkzQ-3hr4A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iiw | POLYCOMB PROTEIN EED (Homo sapiens) |
PF00400(WD40) | 4 | HIS A 185ILE A 172ARG A 216HIS A 189 | None | 1.12A | 5kkzK-3iiwA:undetectable5kkzQ-3iiwA:1.1 | 5kkzK-3iiwA:20.675kkzQ-3iiwA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipw | HYDROLASE TATDFAMILY PROTEIN (Entamoebahistolytica) |
PF01026(TatD_DNase) | 4 | HIS A 81ILE A 114VAL A 80GLN A 129 | None | 1.20A | 5kkzK-3ipwA:undetectable5kkzQ-3ipwA:undetectable | 5kkzK-3ipwA:19.155kkzQ-3ipwA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0h | PHIKZ029 (Pseudomonasvirus phiKZ) |
no annotation | 4 | ILE A 248VAL A 249TYR A 285GLN A 254 | None | 1.25A | 5kkzK-3j0hA:undetectable5kkzQ-3j0hA:undetectable | 5kkzK-3j0hA:23.545kkzQ-3j0hA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jav | INOSITOL1,4,5-TRISPHOSPHATERECEPTOR TYPE 1 (Rattusnorvegicus) |
PF00520(Ion_trans)PF01365(RYDR_ITPR)PF02815(MIR)PF08454(RIH_assoc)PF08709(Ins145_P3_rec) | 4 | ILE A 178VAL A 177TYR A 117ARG A 170 | None | 1.21A | 5kkzK-3javA:3.55kkzQ-3javA:undetectable | 5kkzK-3javA:9.675kkzQ-3javA:5.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7y | ASPARTATEAMINOTRANSFERASE (Plasmodiumfalciparum) |
PF00155(Aminotran_1_2) | 4 | HIS A 262ILE A 263VAL A 264GLN A 82 | None | 1.17A | 5kkzK-3k7yA:undetectable5kkzQ-3k7yA:undetectable | 5kkzK-3k7yA:21.855kkzQ-3k7yA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxp | ALPHA-(N-ACETYLAMINOMETHYLENE)SUCCINICACID HYDROLASE (Mesorhizobiumloti) |
PF12697(Abhydrolase_6) | 4 | HIS A 105ILE A 41TYR A 84HIS A 69 | None CL A 279 (-3.7A)NoneNone | 1.23A | 5kkzK-3kxpA:undetectable5kkzQ-3kxpA:undetectable | 5kkzK-3kxpA:23.065kkzQ-3kxpA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm5 | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) |
PF00069(Pkinase) | 4 | HIS A 156ILE A 154VAL A 155HIS A 79 | None | 1.01A | 5kkzK-3lm5A:undetectable5kkzQ-3lm5A:undetectable | 5kkzK-3lm5A:21.565kkzQ-3lm5A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqb | LOC792177 PROTEIN (Danio rerio) |
PF01400(Astacin) | 4 | ILE A 172VAL A 120TYR A 149GLN A 118 | None | 1.22A | 5kkzK-3lqbA:undetectable5kkzQ-3lqbA:undetectable | 5kkzK-3lqbA:17.985kkzQ-3lqbA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | HIS A 155ILE A 153VAL A 154HIS A 184 | None | 1.02A | 5kkzK-3ma6A:undetectable5kkzQ-3ma6A:undetectable | 5kkzK-3ma6A:20.265kkzQ-3ma6A:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqh | GLYCOSYL HYDROLASE (Bacteroidesthetaiotaomicron) |
PF04616(Glyco_hydro_43) | 4 | ILE A 40VAL A 41TYR A 295HIS A 44 | None | 1.20A | 5kkzK-3nqhA:undetectable5kkzQ-3nqhA:0.8 | 5kkzK-3nqhA:21.175kkzQ-3nqhA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nur | AMIDOHYDROLASE (Staphylococcusaureus) |
PF04909(Amidohydro_2) | 4 | HIS A 192ILE A 161ARG A 164HIS A 231 | CA A 358 (-3.5A)NoneNoneNone | 0.96A | 5kkzK-3nurA:undetectable5kkzQ-3nurA:undetectable | 5kkzK-3nurA:23.165kkzQ-3nurA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oa2 | WBPB (Pseudomonasaeruginosa) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | HIS A 188ILE A 128TYR A 279HIS A 133 | None | 1.15A | 5kkzK-3oa2A:undetectable5kkzQ-3oa2A:undetectable | 5kkzK-3oa2A:21.355kkzQ-3oa2A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on4 | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Legionellapneumophila) |
PF00440(TetR_N) | 4 | HIS A 62ILE A 59VAL A 58GLN A 21 | None | 1.20A | 5kkzK-3on4A:undetectable5kkzQ-3on4A:undetectable | 5kkzK-3on4A:16.865kkzQ-3on4A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 4 | HIS A 864VAL A 865TYR A 751GLN A 772 | SO4 A 994 (-3.9A)NoneNoneNone | 1.18A | 5kkzK-3opyA:undetectable5kkzQ-3opyA:undetectable | 5kkzK-3opyA:18.875kkzQ-3opyA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfm | GGDEF DOMAIN PROTEIN (Pseudomonasprotegens) |
PF00563(EAL) | 4 | ILE A 615VAL A 636GLN A 431HIS A 444 | None | 1.20A | 5kkzK-3pfmA:undetectable5kkzQ-3pfmA:undetectable | 5kkzK-3pfmA:20.275kkzQ-3pfmA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rvx | PEPTIDASE 1 (Dermatophagoidespteronyssinus) |
PF00112(Peptidase_C1) | 4 | HIS A 170ILE A 141VAL A 140TYR A 218 | None | 1.23A | 5kkzK-3rvxA:undetectable5kkzQ-3rvxA:undetectable | 5kkzK-3rvxA:18.125kkzQ-3rvxA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxf | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | HIS A 172ILE A 170VAL A 171HIS A 201 | None | 0.99A | 5kkzK-3sxfA:undetectable5kkzQ-3sxfA:undetectable | 5kkzK-3sxfA:21.395kkzQ-3sxfA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqd | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Coxiellaburnetii) |
PF02348(CTP_transf_3) | 4 | HIS A 224ILE A 223TYR A 187HIS A 183 | None | 1.16A | 5kkzK-3tqdA:undetectable5kkzQ-3tqdA:undetectable | 5kkzK-3tqdA:20.185kkzQ-3tqdA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1t | DMMA HALOALKANEDEHALOGENASE (unidentified) |
PF00561(Abhydrolase_1) | 4 | HIS A 315VAL A 220GLN A 318HIS A 321 | MLI A 351 (-3.3A)NoneNoneNone | 1.06A | 5kkzK-3u1tA:undetectable5kkzQ-3u1tA:undetectable | 5kkzK-3u1tA:21.095kkzQ-3u1tA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wd8 | TYPE III POLYKETIDESYNTHASE QUINOLONESYNTHASE (Citrus xmicrocarpa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | HIS A 303ILE A 345VAL A 302ARG A 328 | None | 1.13A | 5kkzK-3wd8A:undetectable5kkzQ-3wd8A:undetectable | 5kkzK-3wd8A:24.025kkzQ-3wd8A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqy | ALANINE--TRNA LIGASE (Archaeoglobusfulgidus) |
PF01411(tRNA-synt_2c)PF02272(DHHA1)PF07973(tRNA_SAD) | 4 | HIS A 452ILE A 454TYR A 419ARG A 371 | U C1605 ( 4.4A)NoneNone U C1670 ( 4.0A) | 1.13A | 5kkzK-3wqyA:undetectable5kkzQ-3wqyA:0.6 | 5kkzK-3wqyA:18.175kkzQ-3wqyA:12.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x17 | ENDOGLUCANASE (unculturedbacterium) |
no annotation | 4 | HIS B 263ILE B 288VAL B 261GLN B 291 | None | 1.09A | 5kkzK-3x17B:undetectable5kkzQ-3x17B:undetectable | 5kkzK-3x17B:21.155kkzQ-3x17B:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dlk | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Bacillusanthracis) |
PF02222(ATP-grasp)PF02826(2-Hacid_dh_C) | 4 | HIS A 319ILE A 320VAL A 323ARG A 325 | HIS A 319 ( 1.0A)ILE A 320 ( 0.4A)VAL A 323 ( 0.6A)ARG A 325 ( 0.6A) | 1.16A | 5kkzK-4dlkA:undetectable5kkzQ-4dlkA:undetectable | 5kkzK-4dlkA:21.215kkzQ-4dlkA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2u | PHO RADA INTEIN (Pyrococcushorikoshii) |
PF14890(Intein_splicing) | 4 | HIS A 160ILE A 156VAL A 155ARG A 64 | None | 1.15A | 5kkzK-4e2uA:undetectable5kkzQ-4e2uA:undetectable | 5kkzK-4e2uA:16.675kkzQ-4e2uA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eut | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | HIS A 133ILE A 131VAL A 132ARG A 54 | None | 1.17A | 5kkzK-4eutA:2.15kkzQ-4eutA:undetectable | 5kkzK-4eutA:23.425kkzQ-4eutA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | HIS A 133ILE A 131VAL A 132ARG A 54 | NoneNoneNoneSEP A 172 ( 3.2A) | 1.12A | 5kkzK-4euuA:undetectable5kkzQ-4euuA:undetectable | 5kkzK-4euuA:21.895kkzQ-4euuA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0j | NON-STRUCTURALPROTEIN 2 (Rotavirus A) |
PF02509(Rota_NS35) | 4 | ILE A 116VAL A 115GLN A 175HIS A 174 | None | 1.00A | 5kkzK-4g0jA:undetectable5kkzQ-4g0jA:undetectable | 5kkzK-4g0jA:19.875kkzQ-4g0jA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g10 | GLUTATHIONES-TRANSFERASEHOMOLOG (Sphingomonaspaucimobilis) |
PF13417(GST_N_3)PF16865(GST_C_5) | 4 | HIS A 11ILE A 12TYR A 214ARG A 170 | NoneGSH A 300 (-3.3A)ACT A 301 (-4.5A)None | 1.25A | 5kkzK-4g10A:undetectable5kkzQ-4g10A:undetectable | 5kkzK-4g10A:20.665kkzQ-4g10A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkm | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Xanthomonascampestris) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 4 | ILE A 135VAL A 134TYR A 334GLN A 141 | None | 1.16A | 5kkzK-4hkmA:undetectable5kkzQ-4hkmA:0.0 | 5kkzK-4hkmA:22.615kkzQ-4hkmA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENB (Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | VAL A 685TYR A 404GLN A 394HIS A 695 | None | 1.23A | 5kkzK-4iglA:undetectable5kkzQ-4iglA:undetectable | 5kkzK-4iglA:15.655kkzQ-4iglA:8.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irt | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF15892(BNR_4) | 4 | HIS A 90ILE A 92VAL A 35TYR A 57 | None | 1.13A | 5kkzK-4irtA:undetectable5kkzQ-4irtA:undetectable | 5kkzK-4irtA:18.755kkzQ-4irtA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqs | HYPOTHETICAL PROTEIN (Bacteroidesuniformis) |
PF06283(ThuA) | 4 | ILE A 218VAL A 219TYR A 229GLN A 244 | None | 1.28A | 5kkzK-4jqsA:undetectable5kkzQ-4jqsA:undetectable | 5kkzK-4jqsA:19.035kkzQ-4jqsA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldu | AUXIN RESPONSEFACTOR 5 (Arabidopsisthaliana) |
PF02362(B3)PF06507(Auxin_resp) | 4 | HIS A 277ILE A 278VAL A 96TYR A 99 | None | 1.15A | 5kkzK-4lduA:undetectable5kkzQ-4lduA:1.0 | 5kkzK-4lduA:21.045kkzQ-4lduA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m29 | BETA-XYLOSIDASE (Caulobactervibrioides) |
PF01229(Glyco_hydro_39) | 4 | ILE A 86TYR A 148ARG A 147HIS A 143 | None | 1.28A | 5kkzK-4m29A:undetectable5kkzQ-4m29A:undetectable | 5kkzK-4m29A:23.085kkzQ-4m29A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfb | C4-DICARBOXYLATE-BINDING PROTEIN (Fusobacteriumnucleatum) |
PF03480(DctP) | 4 | ILE A 179VAL A 169ARG A 148HIS A 230 | NoneNoneG3P A 407 (-2.9A)None | 1.26A | 5kkzK-4pfbA:undetectable5kkzQ-4pfbA:undetectable | 5kkzK-4pfbA:20.485kkzQ-4pfbA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASEDNA-DIRECTED RNAPOLYMERASE SUBUNIT H (Thermococcuskodakarensis;Thermococcuskodakarensis) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF01191(RNA_pol_Rpb5_C) | 4 | ILE A 867VAL A 868TYR H 75ARG H 77 | None | 1.18A | 5kkzK-4qiwA:2.85kkzQ-4qiwA:undetectable | 5kkzK-4qiwA:17.935kkzQ-4qiwA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Drosophilamelanogaster) |
PF07034(ORC3_N) | 4 | HIS C 312ILE C 311TYR C 72HIS C 110 | None | 0.98A | 5kkzK-4xgcC:undetectable5kkzQ-4xgcC:undetectable | 5kkzK-4xgcC:21.225kkzQ-4xgcC:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xix | CARBONIC ANHYDRASE,ALPHA TYPE (Chlamydomonasreinhardtii) |
PF00194(Carb_anhydrase) | 4 | HIS A 160TYR A 121GLN A 158HIS A 182 | ZN A 401 ( 3.2A)NoneNoneNone | 1.25A | 5kkzK-4xixA:undetectable5kkzQ-4xixA:undetectable | 5kkzK-4xixA:20.705kkzQ-4xixA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyw | O-ANTIGENBIOSYNTHESISGLYCOSYLTRANSFERASEWBNH (Escherichiacoli) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 4 | HIS A 244ILE A 270TYR A 309ARG A 313 | None | 1.21A | 5kkzK-4xywA:undetectable5kkzQ-4xywA:undetectable | 5kkzK-4xywA:20.185kkzQ-4xywA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah1 | TRIACYLGLYCEROLLIPASE (Clostridiumbotulinum) |
no annotation | 4 | HIS A 426ILE A 429VAL A 430TYR A 440 | None | 1.13A | 5kkzK-5ah1A:undetectable5kkzQ-5ah1A:undetectable | 5kkzK-5ah1A:22.125kkzQ-5ah1A:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b16 | RIBONUCLEASE3,DROSHA,RIBONUCLEASE3,DROSHA,RIBONUCLEASE 3 (Homo sapiens) |
PF00035(dsrm)PF00636(Ribonuclease_3)PF14622(Ribonucleas_3_3) | 4 | HIS A 549ILE A 547ARG A 871HIS A 868 | ZN A1402 (-3.4A)NoneNoneNone | 1.08A | 5kkzK-5b16A:2.45kkzQ-5b16A:undetectable | 5kkzK-5b16A:15.565kkzQ-5b16A:10.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6f | BACTERIAL NON-HEMEFERRITIN (Helicobacterpylori) |
PF00210(Ferritin) | 4 | HIS A 107ILE A 109VAL A 105HIS A 114 | None | 1.26A | 5kkzK-5c6fA:3.05kkzQ-5c6fA:undetectable | 5kkzK-5c6fA:17.395kkzQ-5c6fA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey5 | LBCA-B (syntheticconstruct) |
PF00291(PALP) | 4 | HIS B 277ILE B 185VAL B 189HIS B 112 | None | 1.19A | 5kkzK-5ey5B:undetectable5kkzQ-5ey5B:undetectable | 5kkzK-5ey5B:21.965kkzQ-5ey5B:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fg3 | PROBABLE TRANSLATIONINITIATION FACTORIF-2 (Aeropyrumpernix) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2)PF14578(GTP_EFTU_D4) | 4 | HIS A 52ILE A 263VAL A 262GLN A 16 | None | 1.08A | 5kkzK-5fg3A:undetectable5kkzQ-5fg3A:undetectable | 5kkzK-5fg3A:21.305kkzQ-5fg3A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | HIS C 272ILE C 271VAL C 270GLN C 418 | None | 1.18A | 5kkzK-5fseC:undetectable5kkzQ-5fseC:undetectable | 5kkzK-5fseC:22.885kkzQ-5fseC:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc8 | PRENYLTRANSFERENCEFOR PROTEIN (Lavandulalanata) |
PF01255(Prenyltransf) | 4 | HIS A 216ILE A 218VAL A 214HIS A 232 | None | 1.29A | 5kkzK-5hc8A:undetectable5kkzQ-5hc8A:undetectable | 5kkzK-5hc8A:20.535kkzQ-5hc8A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6s | ENDOPLASMICRETICULUMAMINOPEPTIDASE 2 (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 4 | HIS A 634ILE A 632VAL A 633HIS A 664 | None | 1.19A | 5kkzK-5j6sA:undetectable5kkzQ-5j6sA:undetectable | 5kkzK-5j6sA:17.925kkzQ-5j6sA:11.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kha | GLUTAMINE-DEPENDENTNAD+ SYNTHETASE (Acinetobacterbaumannii) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 4 | HIS A 344ILE A 346VAL A 347ARG A 375 | None | 0.86A | 5kkzK-5khaA:undetectable5kkzQ-5khaA:undetectable | 5kkzK-5khaA:22.445kkzQ-5khaA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mvh | BACCELL_00856 (Bacteroidescellulosilyticus) |
PF15892(BNR_4) | 4 | HIS A 90ILE A 92VAL A 35TYR A 57 | None | 1.13A | 5kkzK-5mvhA:undetectable5kkzQ-5mvhA:undetectable | 5kkzK-5mvhA:21.465kkzQ-5mvhA:16.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5nmi | CYTOCHROME B (Bos taurus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 4 | HIS C 267ILE C 268TYR C 278ARG C 282 | None | 0.82A | 5kkzK-5nmiC:50.35kkzQ-5nmiC:undetectable | 5kkzK-5nmiC:48.245kkzQ-5nmiC:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN S17,PUTATIVE (Trypanosomacruzi) |
no annotation | 4 | HIS k 145ILE k 150ARG k 173HIS k 174 | U E 731 ( 4.2A) C E 729 ( 4.8A) U E 730 ( 3.3A)None | 1.17A | 5kkzK-5optk:undetectable5kkzQ-5optk:undetectable | 5kkzK-5optk:16.295kkzQ-5optk:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT B (Methanothermobactersp. CaT2) |
PF00384(Molybdopterin) | 4 | ILE B 249VAL B 146TYR B 148HIS B 160 | None | 1.26A | 5kkzK-5t5iB:undetectable5kkzQ-5t5iB:undetectable | 5kkzK-5t5iB:22.495kkzQ-5t5iB:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux4 | CATHEPSIN D (Rattusnorvegicus) |
no annotation | 4 | ILE A 122VAL A 120GLN A 14HIS A 56 | None | 1.06A | 5kkzK-5ux4A:undetectable5kkzQ-5ux4A:undetectable | 5kkzK-5ux4A:undetectable5kkzQ-5ux4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5van | BETA-KLOTHO (Homo sapiens) |
no annotation | 4 | ILE A 865VAL A 864TYR A 910HIS A 825 | None | 1.24A | 5kkzK-5vanA:undetectable5kkzQ-5vanA:undetectable | 5kkzK-5vanA:undetectable5kkzQ-5vanA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vha | DEAH(ASP-GLU-ALA-HIS)BOX POLYPEPTIDE 36 (Bos taurus) |
no annotation | 4 | ILE A 261VAL A 262TYR A 171ARG A 260 | None | 1.28A | 5kkzK-5vhaA:undetectable5kkzQ-5vhaA:undetectable | 5kkzK-5vhaA:undetectable5kkzQ-5vhaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8q | BIS3 BIPHENYLSYNTHASE (Malus domestica) |
no annotation | 4 | HIS A 300ILE A 342VAL A 299ARG A 325 | None | 1.20A | 5kkzK-5w8qA:undetectable5kkzQ-5w8qA:undetectable | 5kkzK-5w8qA:undetectable5kkzQ-5w8qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgg | RADICAL SAM DOMAINPROTEIN (Ruminiclostridiumthermocellum) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 4 | HIS A 5ILE A 4VAL A 18HIS A 24 | None | 0.93A | 5kkzK-5wggA:undetectable5kkzQ-5wggA:undetectable | 5kkzK-5wggA:20.045kkzQ-5wggA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wpn | FERRITIN (Chaetopterusvariopedatus) |
no annotation | 4 | ILE A 17VAL A 13TYR A 9ARG A 73 | None | 1.10A | 5kkzK-5wpnA:2.15kkzQ-5wpnA:undetectable | 5kkzK-5wpnA:undetectable5kkzQ-5wpnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wx4 | ALKYLQUINOLONESYNTHASE (Tetradiumruticarpum) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | HIS A 309ILE A 351VAL A 308ARG A 334 | None | 1.15A | 5kkzK-5wx4A:undetectable5kkzQ-5wx4A:undetectable | 5kkzK-5wx4A:22.255kkzQ-5wx4A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yt0 | PROBABLE TRANSLATIONINITIATION FACTORIF-2 (Aeropyrumpernix) |
no annotation | 4 | HIS A 52ILE A 263VAL A 262GLN A 16 | None | 1.03A | 5kkzK-5yt0A:undetectable5kkzQ-5yt0A:undetectable | 5kkzK-5yt0A:undetectable5kkzQ-5yt0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 4 | HIS A 703ILE A 705ARG A1342HIS A1339 | None | 1.19A | 5kkzK-5zalA:undetectable5kkzQ-5zalA:undetectable | 5kkzK-5zalA:undetectable5kkzQ-5zalA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar3 | GSI-IIC RT (Geobacillusstearothermophilus) |
no annotation | 4 | ILE A 79VAL A 62ARG A 64GLN A 191 | U C 3 ( 4.0A)NoneNoneDTP A 501 (-4.1A) | 1.05A | 5kkzK-6ar3A:undetectable5kkzQ-6ar3A:undetectable | 5kkzK-6ar3A:21.385kkzQ-6ar3A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btm | ALTERNATIVE COMPLEXIII SUBUNIT BALTERNATIVE COMPLEXIII SUBUNIT CALTERNATIVE COMPLEXIII SUBUNIT F (Flavobacteriumjohnsoniae;Flavobacteriumjohnsoniae;Flavobacteriumjohnsoniae) |
no annotationno annotationno annotation | 4 | ILE F 345VAL C 250TYR C 399HIS B1003 | None | 1.18A | 5kkzK-6btmF:3.25kkzQ-6btmF:undetectable | 5kkzK-6btmF:undetectable5kkzQ-6btmF:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c62 | BIURET HYDROLASE (Pseudomonas sp.ADP) |
no annotation | 4 | HIS A 133ILE A 90TYR A 200HIS A 313 | None | 1.10A | 5kkzK-6c62A:undetectable5kkzQ-6c62A:undetectable | 5kkzK-6c62A:undetectable5kkzQ-6c62A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dhi | - (-) |
no annotation | 4 | HIS A 157ILE A 200VAL A 201GLN A 310 | None | 1.17A | 5kkzK-6dhiA:undetectable5kkzQ-6dhiA:undetectable | 5kkzK-6dhiA:undetectable5kkzQ-6dhiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fq3 | E3 UBIQUITIN-PROTEINLIGASE TRIM71 (Danio rerio) |
no annotation | 4 | ILE A 811TYR A 542ARG A 763GLN A 760 | None | 1.07A | 5kkzK-6fq3A:undetectable5kkzQ-6fq3A:undetectable | 5kkzK-6fq3A:undetectable5kkzQ-6fq3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 4 | HIS A 398VAL A 400TYR A 408HIS A 392 | PEG A 509 ( 4.5A)EDO A 505 (-3.5A)NoneNone | 1.27A | 5kkzK-6gu8A:undetectable5kkzQ-6gu8A:undetectable | 5kkzK-6gu8A:undetectable5kkzQ-6gu8A:undetectable |