SIMILAR PATTERNS OF AMINO ACIDS FOR 5KIR_A_RCXA601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0r PHOSDUCIN

(Bos taurus) 		PF02114
(Phosducin) 		3 ARG P 110
ILE P 133
PHE P 107
 None
 0.69A 5kirA-1a0rP:
0.0		 5kirA-1a0rP:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvo TRANSCRIPTION FACTOR
GAMBIF1

(Anopheles
gambiae) 		PF00554
(RHD_DNA_bind) 		3 ARG A  64
ILE A 149
PHE A  63
 None
 0.44A 5kirA-1bvoA:
undetectable		 5kirA-1bvoA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 ARG A 104
ILE A 115
PHE A 105
 None
 0.74A 5kirA-1do5A:
0.0		 5kirA-1do5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5p APHRODISIN

(Mesocricetus
auratus) 		PF00061
(Lipocalin) 		3 ARG A  34
ILE A  47
PHE A  33
 None
 0.71A 5kirA-1e5pA:
undetectable		 5kirA-1e5pA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ARG A  72
ILE A 103
PHE A  73
 None
 0.73A 5kirA-1ethA:
0.0		 5kirA-1ethA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gji C-REL PROTO-ONCOGENE
PROTEIN

(Gallus gallus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG A  23
ILE A 106
PHE A  22
 None
 0.69A 5kirA-1gjiA:
0.0		 5kirA-1gjiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ARG A 263
ILE A 317
PHE A 369
 None
 0.73A 5kirA-1gytA:
0.0		 5kirA-1gytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ARG A 348
ILE A 399
PHE A 268
 None
 0.69A 5kirA-1hn0A:
1.4		 5kirA-1hn0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqg FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF09163
(Form-deh_trans)
PF12800
(Fer4_4)
PF13247
(Fer4_11) 		3 ARG B  81
ILE B  95
PHE B  82
 None
 0.73A 5kirA-1kqgB:
0.0		 5kirA-1kqgB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ARG B  71
ILE B 102
PHE B  72
 None
 0.75A 5kirA-1lpbB:
undetectable		 5kirA-1lpbB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 ARG A 133
ILE A 136
PHE A 131
 None
 0.76A 5kirA-1o5tA:
undetectable		 5kirA-1o5tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 175
ILE A 147
PHE A 174
 None
 0.76A 5kirA-1pg5A:
undetectable		 5kirA-1pg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		3 ARG B  95
ILE B  83
PHE B  94
 None
 0.76A 5kirA-1r4nB:
undetectable		 5kirA-1r4nB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		3 ARG A 688
ILE A 655
PHE A 660
 None
 0.69A 5kirA-1ru3A:
undetectable		 5kirA-1ru3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 260
ILE A 258
PHE A 259
 None
 0.70A 5kirA-1rxwA:
undetectable		 5kirA-1rxwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG P  59
ILE P 142
PHE P  58
 None
 0.64A 5kirA-1svcP:
undetectable		 5kirA-1svcP:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ARG C 142
ILE C 114
PHE C 143
 None
 0.71A 5kirA-1sxjC:
undetectable		 5kirA-1sxjC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 ARG A 612
ILE A 588
PHE A 621
 None
 0.65A 5kirA-1uusA:
undetectable		 5kirA-1uusA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG B 356
ILE B 439
PHE B 355
 None
 0.70A 5kirA-1vkxB:
undetectable		 5kirA-1vkxB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9w BH0236 PROTEIN

(Bacillus
halodurans) 		PF03422
(CBM_6) 		3 ARG A  58
ILE A 111
PHE A  56
 None
 0.69A 5kirA-1w9wA:
undetectable		 5kirA-1w9wA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgh UBIQUITIN-LIKE 3

(Mus musculus) 		PF13881
(Rad60-SLD_2) 		3 ARG A  72
ILE A  68
PHE A  73
 None
 0.61A 5kirA-1wghA:
undetectable		 5kirA-1wghA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A 158
ILE A 153
PHE A 157
 None
 0.62A 5kirA-1x8vA:
undetectable		 5kirA-1x8vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 ARG A 304
ILE A 245
PHE A 311
 None
 0.76A 5kirA-1xdvA:
undetectable		 5kirA-1xdvA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2y CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00385
(Chromo) 		3 ARG C  18
ILE C  62
PHE C  19
 None
 0.76A 5kirA-2b2yC:
undetectable		 5kirA-2b2yC:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		3 ARG A 184
ILE A 182
PHE A 183
 None
 0.53A 5kirA-2bmfA:
undetectable		 5kirA-2bmfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		3 ARG C  65
ILE C  35
PHE C  66
 None
 0.68A 5kirA-2bruC:
undetectable		 5kirA-2bruC:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		3 ARG A 141
ILE A   5
PHE A 140
 None
 0.54A 5kirA-2gmyA:
undetectable		 5kirA-2gmyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5h HYPOTHETICAL PROTEIN
AF1531

(Archaeoglobus
fulgidus) 		PF04919
(DUF655) 		3 ARG A 150
ILE A 161
PHE A 119
 None
 0.73A 5kirA-2i5hA:
undetectable		 5kirA-2i5hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		3 ARG A1059
ILE A1047
PHE A1060
 None
 0.57A 5kirA-2iphA:
undetectable		 5kirA-2iphA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		3 ARG A 302
ILE A 311
PHE A 189
 None
 0.66A 5kirA-2nq2A:
undetectable		 5kirA-2nq2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		3 ARG A  35
ILE A 118
PHE A  34
 None
 0.53A 5kirA-2o61A:
undetectable		 5kirA-2o61A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ARG A 216
ILE A 107
PHE A 217
 None
 0.70A 5kirA-2vmfA:
undetectable		 5kirA-2vmfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ARG B 581
ILE B 506
PHE B 582
 None
 0.72A 5kirA-2w55B:
undetectable		 5kirA-2w55B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 3 ARG A 258
ILE A 232
PHE A 257
 None
 0.57A 5kirA-2wb7A:
undetectable		 5kirA-2wb7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 ARG A 431
ILE A 448
PHE A 457
 None
 0.69A 5kirA-2x49A:
0.0		 5kirA-2x49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		3 ARG A 497
ILE A 514
PHE A 498
 None
 0.56A 5kirA-3a0rA:
0.2		 5kirA-3a0rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0v SENSOR PROTEIN

(Thermotoga
maritima) 		PF00989
(PAS) 		3 ARG A 497
ILE A 514
PHE A 498
 None
 0.51A 5kirA-3a0vA:
undetectable		 5kirA-3a0vA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ARG A 117
ILE A 112
PHE A 142
 None
 0.44A 5kirA-3bazA:
undetectable		 5kirA-3bazA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 3 ARG A 180
ILE A 188
PHE A 179
 None
 0.57A 5kirA-3c4aA:
undetectable		 5kirA-3c4aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chm COP9 SIGNALOSOME
COMPLEX SUBUNIT 7

(Arabidopsis
thaliana) 		PF01399
(PCI) 		3 ARG A 160
ILE A 140
PHE A  40
 None
 0.54A 5kirA-3chmA:
undetectable		 5kirA-3chmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq3 INORGANIC
PYROPHOSPHATASE:BACT
ERIAL/ARCHAEAL
INORGANIC
PYROPHOSPHATASE

(Brucella
abortus) 		PF00719
(Pyrophosphatase) 		3 ARG A  44
ILE A  29
PHE A  45
 None
 0.58A 5kirA-3fq3A:
undetectable		 5kirA-3fq3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG A 685
ILE A 652
PHE A 657
 None
 0.69A 5kirA-3gitA:
undetectable		 5kirA-3gitA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ARG A   5
ILE A 149
PHE A   4
 None
 0.73A 5kirA-3h39A:
undetectable		 5kirA-3h39A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		3 ARG A 337
ILE A 339
PHE A 340
 None
 0.74A 5kirA-3h5cA:
undetectable		 5kirA-3h5cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		3 ARG A 338
ILE A   5
PHE A 339
 None
 0.68A 5kirA-3hfqA:
undetectable		 5kirA-3hfqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hib PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF02889
(Sec63) 		3 ARG A1995
ILE A1997
PHE A2000
 None
 0.62A 5kirA-3hibA:
undetectable		 5kirA-3hibA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 ARG A 175
ILE A 208
PHE A 174
 None
 0.61A 5kirA-3i04A:
undetectable		 5kirA-3i04A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE

(Bartonella
henselae) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		3 ARG A 189
ILE A 150
PHE A 203
 None
 0.73A 5kirA-3ijpA:
undetectable		 5kirA-3ijpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ARG A1691
ILE A1584
PHE A1692
 None
 0.75A 5kirA-3jb9A:
undetectable		 5kirA-3jb9A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ARG A 676
ILE A 673
PHE A 675
 None
 0.68A 5kirA-3karA:
undetectable		 5kirA-3karA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		3 ARG A 380
ILE A 375
PHE A 379
 None
 0.74A 5kirA-3kv4A:
undetectable		 5kirA-3kv4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 ARG A  44
ILE A  15
PHE A  45
 None
 0.75A 5kirA-3lq0A:
undetectable		 5kirA-3lq0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 ARG A  96
ILE A  94
PHE A  95
 None
 0.59A 5kirA-3ml0A:
undetectable		 5kirA-3ml0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p39 NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 ARG A 135
ILE A 132
PHE A 133
 None
 0.58A 5kirA-3p39A:
undetectable		 5kirA-3p39A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 ARG A 336
ILE A 284
PHE A 337
 None
 0.61A 5kirA-3pr4A:
undetectable		 5kirA-3pr4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd4 UNCHARACTERIZED
PROTEIN

(Proteus penneri) 		PF10694
(DUF2500) 		3 ARG A  78
ILE A  56
PHE A  79
 None
 0.70A 5kirA-3rd4A:
undetectable		 5kirA-3rd4A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 ARG A  59
ILE A  80
PHE A  60
 None
 0.75A 5kirA-3rl3A:
undetectable		 5kirA-3rl3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		3 ARG A 303
ILE A 288
PHE A 302
 None
 0.76A 5kirA-3s3rA:
undetectable		 5kirA-3s3rA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		3 ARG A 657
ILE A 654
PHE A 656
 None
 0.74A 5kirA-3t0qA:
undetectable		 5kirA-3t0qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0i PROBABLE
FAD-BINDING,
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Brucella
abortus) 		PF12900
(Pyridox_ox_2) 		3 ARG A  39
ILE A  15
PHE A  40
 None
 0.59A 5kirA-3u0iA:
undetectable		 5kirA-3u0iA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ARG A1288
ILE A1286
PHE A1287
 None
 0.75A 5kirA-3ummA:
undetectable		 5kirA-3ummA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uws HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF03415
(Peptidase_C11) 		3 ARG B 312
ILE B 314
PHE B 313
 None
 0.72A 5kirA-3uwsB:
undetectable		 5kirA-3uwsB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		3 ARG A 281
ILE A 253
PHE A 278
 None
 0.73A 5kirA-3wdqA:
undetectable		 5kirA-3wdqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 ARG A 515
ILE A 485
PHE A 503
 None
 0.73A 5kirA-3zxlA:
undetectable		 5kirA-3zxlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 ARG A 159
ILE A 165
PHE A 178
 None
 0.45A 5kirA-4aigA:
undetectable		 5kirA-4aigA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ARG A 960
ILE A 985
PHE A1601
 None
 0.72A 5kirA-4amcA:
undetectable		 5kirA-4amcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		3 ARG A 523
ILE A 491
PHE A 475
 None
 0.76A 5kirA-4amfA:
undetectable		 5kirA-4amfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ARG A 508
ILE A 514
PHE A 515
 None
 0.71A 5kirA-4areA:
undetectable		 5kirA-4areA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG A 186
ILE A 268
PHE A 182
 None
 0.75A 5kirA-4bziA:
1.1		 5kirA-4bziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF14554
(VEGF_C) 		3 ARG A  61
ILE A 127
PHE A  62
 None
 0.75A 5kirA-4deqA:
undetectable		 5kirA-4deqA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 337
ILE A 357
PHE A 336
 None
 0.72A 5kirA-4dwdA:
undetectable		 5kirA-4dwdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hku TETR TRANSCRIPTIONAL
REGULATOR

(Listeria
monocytogenes) 		PF00440
(TetR_N) 		3 ARG A  65
ILE A  67
PHE A  68
 None
 0.75A 5kirA-4hkuA:
1.6		 5kirA-4hkuA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		3 ARG A  79
ILE A  81
PHE A 118
 None
 0.74A 5kirA-4i8qA:
undetectable		 5kirA-4i8qA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		3 ARG A 440
ILE A 448
PHE A  21
 None
 0.55A 5kirA-4k35A:
undetectable		 5kirA-4k35A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 ARG A  57
ILE A 162
PHE A  58
 None
 0.76A 5kirA-4ow8A:
undetectable		 5kirA-4ow8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 ARG A1797
ILE A1788
PHE A1695
 None
 0.73A 5kirA-4p1tA:
undetectable		 5kirA-4p1tA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 ARG A 514
ILE A 518
PHE A 519
 None
 0.21A 5kirA-4ph9A:
62.4		 5kirA-4ph9A:
87.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A 412
ILE A 255
PHE A 413
 None
 0.62A 5kirA-4qavA:
undetectable		 5kirA-4qavA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A 159
ILE A  96
PHE A 160
 None
 0.68A 5kirA-4ruhA:
undetectable		 5kirA-4ruhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uow TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 ARG 1  57
ILE 1  69
PHE 1  56
 None
 0.69A 5kirA-4uow1:
undetectable		 5kirA-4uow1:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywk CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A  94
ILE A  44
PHE A  95
 None
 0.69A 5kirA-4ywkA:
undetectable		 5kirA-4ywkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A  94
ILE A  44
PHE A  95
 None
 0.76A 5kirA-4ywlA:
undetectable		 5kirA-4ywlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		3 ARG A 415
ILE A 420
PHE A 416
 None
 0.76A 5kirA-5ddbA:
0.0		 5kirA-5ddbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		3 ARG A 159
ILE A 175
PHE A 160
 None
 0.70A 5kirA-5dlkA:
undetectable		 5kirA-5dlkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 ARG A 645
ILE A 649
PHE A 644
 None
 0.74A 5kirA-5f0oA:
0.7		 5kirA-5f0oA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h28 OXYSTEROL-BINDING
PROTEIN HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF13637
(Ank_4) 		3 ARG A 226
ILE A 271
PHE A 224
 None
 0.74A 5kirA-5h28A:
undetectable		 5kirA-5h28A:
16.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 ARG A 513
ILE A 517
PHE A 518
 None
 0.15A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1

(Chaetomium
thermophilum) 		PF03164
(Mon1) 		3 ARG A 275
ILE A 289
PHE A 276
 None
 0.50A 5kirA-5lddA:
undetectable		 5kirA-5lddA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 3 ARG A 378
ILE A 376
PHE A 377
 None
 0.61A 5kirA-5mjsA:
undetectable		 5kirA-5mjsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21

(Kluyveromyces
lactis) 		no annotation 3 ARG A 247
ILE A 253
PHE A 246
 None
 0.75A 5kirA-5mu3A:
undetectable		 5kirA-5mu3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		3 ARG C 459
ILE C 456
PHE C 458
 None
 0.73A 5kirA-5nd7C:
undetectable		 5kirA-5nd7C:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 ARG T2445
ILE T 982
PHE T2480
 None
 0.75A 5kirA-5ojsT:
undetectable		 5kirA-5ojsT:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 365
ILE A 378
PHE A 364
 None
 0.60A 5kirA-5szqA:
undetectable		 5kirA-5szqA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 ARG C 813
ILE C 815
PHE C 816
 None
 0.67A 5kirA-5tw1C:
undetectable		 5kirA-5tw1C:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 ARG A 353
ILE A 235
PHE A 277
 None
 0.67A 5kirA-5vi6A:
undetectable		 5kirA-5vi6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		3 ARG A 210
ILE A 268
PHE A 254
 None
 0.76A 5kirA-5vpqA:
undetectable		 5kirA-5vpqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 3 ARG A 217
ILE A  12
PHE A 216
 C7V  A 501 (-3.8A)
None
C7V  A 501 (-3.2A)
 0.66A 5kirA-6b0tA:
undetectable		 5kirA-6b0tA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 3 ARG A 409
ILE A 379
PHE A 408
 None
 0.68A 5kirA-6b9sA:
undetectable		 5kirA-6b9sA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 3 ARG B 182
ILE B 167
PHE B 181
 None
 0.63A 5kirA-6eysB:
undetectable		 5kirA-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		no annotation 3 ARG A 396
ILE A 398
PHE A 394
 None
 0.72A 5kirA-6f9sA:
undetectable		 5kirA-6f9sA:
8.04