SIMILAR PATTERNS OF AMINO ACIDS FOR 5KIR_A_RCXA601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bh6 | SUBTILISIN DY (Bacilluslicheniformis) |
PF00082(Peptidase_S8) | 5 | ALA A 152VAL A 68GLY A 70ALA A 69LEU A 90 | 1BH A 300 ( 3.7A)NoneNoneNoneNone | 1.01A | 5kirA-1bh6A:undetectable | 5kirA-1bh6A:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 36LEU A 37ALA A 76GLY A 47LEU A 362 | None | 1.03A | 5kirA-1bkhA:0.0 | 5kirA-1bkhA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3l | SUBTILISIN-CARLSBERG (Bacilluslicheniformis) |
PF00082(Peptidase_S8) | 5 | ALA A 152VAL A 68GLY A 70ALA A 69LEU A 90 | XE A 281 ( 3.9A)NoneNoneNoneNone | 1.01A | 5kirA-1c3lA:undetectable | 5kirA-1c3lA:18.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 9 | HIS A 90GLN A 192VAL A 349LEU A 352TYR A 355TRP A 387GLY A 526ALA A 527LEU A 531 | NoneNoneSCL A 700 ( 4.6A)SCL A 700 ( 4.8A)SCL A 700 (-4.3A)NoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.30A | 5kirA-1ebvA:58.4 | 5kirA-1ebvA:63.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gwc | GLUTATHIONES-TRANSFERASE TSI-1 (Aegilopstauschii) |
PF00043(GST_C)PF02798(GST_N) | 5 | VAL A 168TRP A 195ALA A 204VAL A 163ALA A 164 | None | 1.08A | 5kirA-1gwcA:1.6 | 5kirA-1gwcA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | VAL A 152ALA A 126VAL A 363GLY A 361LEU A 356 | NoneNoneNoneNoneHEM A 410 ( 4.4A) | 1.04A | 5kirA-1jioA:undetectable | 5kirA-1jioA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy1 | TYROSYL-DNAPHOSPHODIESTERASE (Homo sapiens) |
PF06087(Tyr-DNA_phospho) | 5 | VAL A 227TYR A 537ALA A 332SER A 334LEU A 335 | None | 0.93A | 5kirA-1jy1A:0.0 | 5kirA-1jy1A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krh | BENZOATE1,2-DIOXYGENASEREDUCTASE (Acinetobactersp.) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | VAL A 241TYR A 305ALA A 328SER A 237LEU A 232 | None | 1.08A | 5kirA-1krhA:0.0 | 5kirA-1krhA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n61 | CARBON MONOXIDEDEHYDROGENASE MEDIUMCHAIN (Oligotrophacarboxidovorans) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | LEU C 51ALA C 46GLY C 33ALA C 32LEU C 54 | NoneNoneFAD C3932 (-3.4A)FAD C3932 (-3.5A)None | 1.04A | 5kirA-1n61C:0.0 | 5kirA-1n61C:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o8c | YHDH (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 265ALA A 243VAL A 159GLY A 128ALA A 131 | NoneNDP A1325 (-3.5A)NDP A1325 (-4.0A)NoneNone | 1.06A | 5kirA-1o8cA:undetectable | 5kirA-1o8cA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | VAL A 642ALA A 638VAL A 625GLY A 623ALA A 621 | None | 0.94A | 5kirA-1ofeA:undetectable | 5kirA-1ofeA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 6 | VAL A 40LEU A 41ALA A 68GLY A 250ALA A 31LEU A 282 | None | 1.09A | 5kirA-1qhgA:undetectable | 5kirA-1qhgA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhh | PROTEIN (PCRA(SUBUNIT)) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 6 | VAL A 40LEU A 41ALA A 68GLY B 250ALA A 31LEU B 282 | None | 1.10A | 5kirA-1qhhA:undetectable | 5kirA-1qhhA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrv | GLYCOSYLTRANSFERASEGTFD (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 5 | VAL A 46ALA A 38VAL A 14GLY A 17LEU A 219 | VAL A 46 ( 0.6A)ALA A 38 ( 0.0A)VAL A 14 ( 0.6A)GLY A 17 ( 0.0A)LEU A 219 ( 0.6A) | 0.89A | 5kirA-1rrvA:undetectable | 5kirA-1rrvA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sc6 | D-3-PHOSPHOGLYCERATEDEHYDROGENASE (Escherichiacoli) |
PF00389(2-Hacid_dh)PF01842(ACT)PF02826(2-Hacid_dh_C) | 5 | LEU A 65ALA A 93VAL A 101GLY A 80ALA A 81 | None | 1.02A | 5kirA-1sc6A:undetectable | 5kirA-1sc6A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sez | PROTOPORPHYRINOGENOXIDASE,MITOCHONDRIAL (Nicotianatabacum) |
PF01593(Amino_oxidase) | 5 | VAL A 332VAL A 173GLY A 175ALA A 174LEU A 369 | NoneNoneOMN A 601 (-3.6A)NoneOMN A 601 (-3.7A) | 1.06A | 5kirA-1sezA:undetectable | 5kirA-1sezA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uaa | PROTEIN(ATP-DEPENDENT DNAHELICASE REP.) (Escherichiacoli) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 31ALA A 59GLY A 241ALA A 22LEU A 273 | None | 0.98A | 5kirA-1uaaA:undetectable | 5kirA-1uaaA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz4 | MAN5A (Cellvibriomixtus) |
PF00150(Cellulase) | 5 | VAL A 127LEU A 79ALA A 377ALA A 50LEU A 113 | None | 0.84A | 5kirA-1uz4A:undetectable | 5kirA-1uz4A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ark | FLAVODOXIN (Aquifexaeolicus) |
PF00258(Flavodoxin_1) | 5 | VAL A 6LEU A 36GLY A 25ALA A 26LEU A 158 | None | 0.99A | 5kirA-2arkA:undetectable | 5kirA-2arkA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb1 | O-ACETYL HOMOSERINESULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 5 | VAL A 174TRP A 223ALA A 71ALA A 87LEU A 88 | None | 0.95A | 5kirA-2cb1A:undetectable | 5kirA-2cb1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7s | RNA-DEPENDENT RNAPOLYMERASE (Foot-and-mouthdisease virus) |
PF00680(RdRP_1) | 5 | LEU A 442ALA A 410VAL A 427GLY A 429ALA A 428 | None | 1.08A | 5kirA-2d7sA:undetectable | 5kirA-2d7sA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gko | SUBTILISINMICROBIAL SERINEPROTEINASES (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | ALA A 165VAL A 75GLY A 77ALA A 76LEU A 98 | PMS A 601 ( 3.8A)NoneNoneNoneNone | 0.92A | 5kirA-2gkoA:undetectable | 5kirA-2gkoA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i34 | ACID PHOSPHATASE (Bacillusanthracis) |
PF03767(Acid_phosphat_B) | 5 | VAL A 70ALA A 98GLY A 142ALA A 143LEU A 110 | None | 1.08A | 5kirA-2i34A:undetectable | 5kirA-2i34A:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4k | GENERAL STRESSPROTEIN 13 (Bacillussubtilis) |
PF00575(S1) | 5 | ALA A 78VAL A 35GLY A 22ALA A 23LEU A 18 | None | 0.89A | 5kirA-2k4kA:undetectable | 5kirA-2k4kA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjr | PROTEIN (HELICASEPCRA) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 6 | VAL A 40LEU A 41ALA A 68GLY A 250ALA A 31LEU A 282 | None | 1.10A | 5kirA-2pjrA:undetectable | 5kirA-2pjrA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwz | MALATE DEHYDROGENASE (Escherichiacoli) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 6 | VAL A 102LEU A 101ALA A 66VAL A 73GLY A 115LEU A 143 | None | 1.41A | 5kirA-2pwzA:undetectable | 5kirA-2pwzA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdw | PUTATIVE HEXOSEOXIDASE (Nonomuraeagerenzanensis) |
PF01565(FAD_binding_4)PF08031(BBE) | 6 | VAL A 176LEU A 179ALA A 198GLY A 216ALA A 416LEU A 417 | None | 1.49A | 5kirA-2wdwA:undetectable | 5kirA-2wdwA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | VAL A 313LEU A 415VAL A 267GLY A 269ALA A 268 | HEM A1434 ( 4.9A)NoneNoneHEM A1434 (-3.3A)HEM A1434 (-3.5A) | 1.05A | 5kirA-2xn8A:undetectable | 5kirA-2xn8A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yr5 | PRO-ENZYME OFL-PHENYLALANINEOXIDASE (Pseudomonas sp.P-501) |
no annotation | 5 | ALA A 236VAL A 214GLY A 211ALA A 210LEU A 206 | None | 0.90A | 5kirA-2yr5A:undetectable | 5kirA-2yr5A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a71 | EXO-ARABINANASE (Penicilliumchrysogenum) |
no annotation | 5 | LEU A 108ALA A 340GLY A 127ALA A 126LEU A 141 | None | 0.98A | 5kirA-3a71A:undetectable | 5kirA-3a71A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aam | ENDONUCLEASE IV (Thermusthermophilus) |
PF01261(AP_endonuc_2) | 5 | VAL A 107VAL A 117GLY A 120ALA A 121LEU A 136 | None | 1.08A | 5kirA-3aamA:undetectable | 5kirA-3aamA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 6 | HIS A 919VAL A 633LEU A 630TRP A 581ALA A 552LEU A 550 | None | 1.35A | 5kirA-3bgaA:0.5 | 5kirA-3bgaA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d43 | SPHERICASE (Lysinibacillussphaericus) |
PF00082(Peptidase_S8) | 5 | ALA A 166VAL A 75GLY A 77ALA A 76LEU A 99 | None | 1.00A | 5kirA-3d43A:undetectable | 5kirA-3d43A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 6 | HIS A 895VAL A 609LEU A 606TRP A 557ALA A 528LEU A 526 | None | 1.38A | 5kirA-3decA:undetectable | 5kirA-3decA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dyj | TALIN-1 (Mus musculus) |
no annotation | 6 | ALA A2023VAL A2062GLY A2065ALA A2066SER A2068LEU A2069 | None | 1.27A | 5kirA-3dyjA:undetectable | 5kirA-3dyjA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fyq | CG6831-PA (TALIN) (Drosophilamelanogaster) |
no annotation | 5 | ALA A2032VAL A2071ALA A2075SER A2077LEU A2078 | None | 1.07A | 5kirA-3fyqA:undetectable | 5kirA-3fyqA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 457ALA A 495VAL A 113GLY A 112ALA A 111 | HBX A 530 (-4.3A)NoneFAD A 522 (-3.7A)FAD A 522 (-3.9A)FAD A 522 ( 3.0A) | 0.93A | 5kirA-3gdnA:undetectable | 5kirA-3gdnA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h6e | CARBOHYDRATE KINASE,FGGY (Novosphingobiumaromaticivorans) |
PF00370(FGGY_N) | 5 | ALA A 325VAL A 400ALA A 404SER A 407LEU A 408 | None | 0.79A | 5kirA-3h6eA:undetectable | 5kirA-3h6eA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hz6 | XYLULOKINASE (Chromobacteriumviolaceum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | VAL A 339LEU A 379ALA A 330VAL A 381GLY A 384 | None | 0.95A | 5kirA-3hz6A:undetectable | 5kirA-3hz6A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lfu | DNA HELICASE II (Escherichiacoli) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 6 | VAL A 38LEU A 39ALA A 66GLY A 247ALA A 29LEU A 279 | None | 1.10A | 5kirA-3lfuA:undetectable | 5kirA-3lfuA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls1 | SLL1638 PROTEIN (Synechocystissp. PCC 6803) |
PF05757(PsbQ) | 5 | ALA A 51GLY A 88ALA A 90SER A 92LEU A 93 | None | 1.09A | 5kirA-3ls1A:undetectable | 5kirA-3ls1A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpi | GLUTARYL-COADEHYDROGENASE (Desulfococcusmultivorans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | HIS A 244LEU A 102VAL A 55GLY A 53SER A 118 | None | 0.98A | 5kirA-3mpiA:undetectable | 5kirA-3mpiA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbm | PTS SYSTEM,LACTOSE-SPECIFICIIBC COMPONENTS (Streptococcuspneumoniae) |
PF02302(PTS_IIB) | 5 | VAL A 512LEU A 508TYR A 538VAL A 460GLY A 491 | None | 1.08A | 5kirA-3nbmA:undetectable | 5kirA-3nbmA:11.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx4 | PUTATIVEOXIDOREDUCTASE (Salmonellaenterica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 265ALA A 243VAL A 159GLY A 128ALA A 131 | NoneNAP A 330 (-3.5A)NAP A 330 (-3.8A)NoneNone | 1.08A | 5kirA-3nx4A:undetectable | 5kirA-3nx4A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocd | SOXA (Starkeyanovella) |
no annotation | 5 | LEU A 90VAL A 140ALA A 144SER A 147LEU A 268 | None | 0.94A | 5kirA-3ocdA:undetectable | 5kirA-3ocdA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 458ALA A 496VAL A 113GLY A 112ALA A 111 | NoneNoneFAD A 773 (-3.7A)FAD A 773 (-3.9A)FAD A 773 (-3.0A) | 0.98A | 5kirA-3redA:undetectable | 5kirA-3redA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s99 | BASIC MEMBRANELIPOPROTEIN (Brucellaabortus) |
PF02608(Bmp) | 5 | VAL A 291LEU A 294ALA A 300VAL A 132GLY A 134 | None | 0.97A | 5kirA-3s99A:undetectable | 5kirA-3s99A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slk | POLYKETIDE SYNTHASEEXTENDER MODULE 2 (Saccharopolysporaspinosa) |
PF08240(ADH_N)PF08659(KR)PF13602(ADH_zinc_N_2) | 5 | LEU A 663ALA A 658VAL A 622GLY A 624LEU A 629 | None | 0.87A | 5kirA-3slkA:undetectable | 5kirA-3slkA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti7 | BASIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE BPRV (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | VAL A 37ALA A 204VAL A 109GLY A 111ALA A 110 | None | 1.09A | 5kirA-3ti7A:undetectable | 5kirA-3ti7A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdb | PROBABLEATP-DEPENDENT CLPPROTEASE ATP-BINDINGSUBUNIT (Mycobacteriumtuberculosis) |
PF02861(Clp_N) | 5 | LEU A 110ALA A 95ALA A 45SER A 48LEU A 49 | None | 0.79A | 5kirA-3wdbA:0.8 | 5kirA-3wdbA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4etz | PELD (Pseudomonasaeruginosa) |
PF13492(GAF_3)PF16963(PelD_GGDEF) | 5 | GLN A 194VAL A 188LEU A 191ALA A 300LEU A 267 | None | 1.06A | 5kirA-4etzA:undetectable | 5kirA-4etzA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3m | BH0337 PROTEIN (Bacillushalodurans) |
PF09704(Cas_Cas5d) | 5 | VAL A 144LEU A 9GLY A 40ALA A 42SER A 44 | None | 0.94A | 5kirA-4f3mA:undetectable | 5kirA-4f3mA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 14 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | LEU N 290ALA N 401ALA N 329SER N 332LEU N 333 | None | 1.09A | 5kirA-4heaN:undetectable | 5kirA-4heaN:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 5 | VAL A 79GLY A 81ALA A 83SER A 85LEU A 86 | None | 0.92A | 5kirA-4j9uA:3.1 | 5kirA-4j9uA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcd | MAJOR CAPSID PROTEINVP1 (Humanpolyomavirus 2) |
PF00718(Polyoma_coat) | 5 | ALA A 255VAL A 111GLY A 113SER A 116LEU A 117 | None | 1.02A | 5kirA-4jcdA:undetectable | 5kirA-4jcdA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 5 | VAL A 923LEU A 926VAL A 961ALA A 965LEU A 997 | None | 1.06A | 5kirA-4k0eA:0.6 | 5kirA-4k0eA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3j | HEPATOCYTE GROWTHFACTOR (Homo sapiens) |
PF00089(Trypsin) | 5 | VAL A 687ALA A 659GLY A 675SER A 522LEU A 530 | None | 0.89A | 5kirA-4k3jA:undetectable | 5kirA-4k3jA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | VAL A 91ALA A 235VAL A 130GLY A 132ALA A 131 | None | 1.07A | 5kirA-4kg7A:undetectable | 5kirA-4kg7A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ky0 | PROTON/GLUTAMATESYMPORTER, SDFFAMILY (Thermococcuskodakarensis) |
PF00375(SDF) | 5 | VAL A 153LEU A 154GLY A 309ALA A 310LEU A 284 | None | 1.07A | 5kirA-4ky0A:undetectable | 5kirA-4ky0A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzd | NISIN LEADERPEPTIDE-PROCESSINGSERINE PROTEASE NISP (Lactococcuslactis) |
PF00082(Peptidase_S8) | 5 | VAL A 255ALA A 404VAL A 310GLY A 312ALA A 311 | None | 1.09A | 5kirA-4mzdA:undetectable | 5kirA-4mzdA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nng | 30S RIBOSOMALPROTEIN S1 (Mycobacteriumtuberculosis) |
PF00575(S1) | 5 | ALA A 365VAL A 321GLY A 308ALA A 309LEU A 304 | None | 1.02A | 5kirA-4nngA:undetectable | 5kirA-4nngA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1m | ENOYL-ACYL CARRIERREDUCTASE (Toxoplasmagondii) |
PF13561(adh_short_C2) | 5 | LEU A 286VAL A 266GLY A 268ALA A 270LEU A 274 | None | 0.81A | 5kirA-4o1mA:undetectable | 5kirA-4o1mA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4owt | INTEGRATOR COMPLEXSUBUNIT 3 (Homo sapiens) |
PF10189(Ints3) | 5 | VAL A 149ALA A 112VAL A 157GLY A 159ALA A 160 | None | 1.06A | 5kirA-4owtA:undetectable | 5kirA-4owtA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oye | 425AA LONGHYPOTHETICAL PROTONGLUTAMATE SYMPORTPROTEIN (Pyrococcushorikoshii) |
PF00375(SDF) | 5 | VAL A 151LEU A 152GLY A 306ALA A 307LEU A 282 | None | 1.07A | 5kirA-4oyeA:undetectable | 5kirA-4oyeA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe3 | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Rhodobactersphaeroides) |
PF03480(DctP) | 5 | GLN A 139LEU A 355TRP A 334ALA A 135GLY A 328 | None | 1.09A | 5kirA-4pe3A:undetectable | 5kirA-4pe3A:19.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 12 | HIS A 90GLN A 193VAL A 350LEU A 353TYR A 356TRP A 388ALA A 517VAL A 524GLY A 527ALA A 528SER A 531LEU A 532 | NoneNoneIBP A 601 (-4.3A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)NoneNoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 0.25A | 5kirA-4ph9A:62.4 | 5kirA-4ph9A:87.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pot | VP1 (Humanpolyomavirus 9) |
PF00718(Polyoma_coat) | 5 | ALA A 267VAL A 122GLY A 124SER A 127LEU A 128 | NoneEDO A 403 (-4.4A)NoneNoneNone | 1.06A | 5kirA-4potA:undetectable | 5kirA-4potA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psd | CARBOHYDRATEESTERASE FAMILY 5 (Trichodermareesei) |
PF01083(Cutinase) | 5 | HIS A 249VAL A 159LEU A 158GLY A 118LEU A 108 | None | 1.01A | 5kirA-4psdA:undetectable | 5kirA-4psdA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q60 | PROLINE RACEMASE (Burkholderiamultivorans) |
PF05544(Pro_racemase) | 5 | ALA A 74VAL A 97GLY A 95SER A 10LEU A 291 | None | 1.09A | 5kirA-4q60A:undetectable | 5kirA-4q60A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r86 | RND FAMILYAMINOGLYCOSIDE/MULTIDRUG EFFLUX PUMP (Salmonellaenterica) |
PF00873(ACR_tran) | 5 | GLN A 176VAL A 169GLY A 229ALA A 232LEU A 154 | None | 0.98A | 5kirA-4r86A:undetectable | 5kirA-4r86A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnc | ESTERASE (Rhodococcus sp.ECU1013) |
PF12697(Abhydrolase_6) | 5 | HIS A 253VAL A 219LEU A 124GLY A 137ALA A 232 | None | 0.99A | 5kirA-4rncA:undetectable | 5kirA-4rncA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | GLN A 254GLY A 356ALA A 357SER A 360LEU A 361 | None | 0.83A | 5kirA-4rt6A:undetectable | 5kirA-4rt6A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqv | ALGM1ALGM2 (Sphingomonassp.) |
PF00528(BPD_transp_1) | 5 | LEU B 232TYR B 213VAL B 237GLY A 150ALA A 149 | None | 1.04A | 5kirA-4tqvB:undetectable | 5kirA-4tqvB:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us5 | LUCIFERASE-LIKEMONOOXYGENASE (Streptomycesbottropensis) |
PF00296(Bac_luciferase) | 5 | VAL A 309ALA A 28VAL A 41GLY A 74ALA A 42 | NA A1340 (-3.7A)NoneNoneNoneNone | 0.94A | 5kirA-4us5A:0.0 | 5kirA-4us5A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqb | NADP-DEPENDENTDEHYDROGENASE (Rhodobactersphaeroides) |
PF02826(2-Hacid_dh_C) | 5 | VAL A 176ALA A 180GLY A 149ALA A 150LEU A 154 | None | 0.80A | 5kirA-4zqbA:undetectable | 5kirA-4zqbA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4j | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | VAL A 327ALA A 331GLY A 308ALA A 309LEU A 313 | None | 1.06A | 5kirA-5a4jA:undetectable | 5kirA-5a4jA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5azs | OUTER MEMBRANEPROTEIN OPRJ (Pseudomonasaeruginosa) |
PF02321(OEP) | 5 | ALA A 345GLY A 286ALA A 287SER A 129LEU A 130 | None | 1.02A | 5kirA-5azsA:undetectable | 5kirA-5azsA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | VAL A 425ALA A 513GLY A 535ALA A 742LEU A 743 | None | 0.96A | 5kirA-5dotA:undetectable | 5kirA-5dotA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5et1 | ESPIN (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5) | 5 | VAL A 107LEU A 108ALA A 132GLY A 127LEU A 90 | NoneNoneGOL A 401 (-3.7A)GOL A 402 ( 4.4A)None | 0.99A | 5kirA-5et1A:undetectable | 5kirA-5et1A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbz | ENZYME SUBTILASESUBHAL FROM BACILLUSHALMAPALUS (Bacillushalmapalus) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | ALA A 158VAL A 72GLY A 74ALA A 73LEU A 91 | NoneNone5VV A 1 ( 4.8A)NoneNone | 0.93A | 5kirA-5fbzA:undetectable | 5kirA-5fbzA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffn | ENZYME SUBTILASESUBTY FROM BACILLUSSP. TY145 (Bacillus sp.(in: Bacteria)) |
PF00082(Peptidase_S8) | 5 | ALA A 167VAL A 76GLY A 78ALA A 77LEU A 100 | None | 0.98A | 5kirA-5ffnA:undetectable | 5kirA-5ffnA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffn | ENZYME SUBTILASESUBTY FROM BACILLUSSP. TY145 (Bacillus sp.(in: Bacteria)) |
PF00082(Peptidase_S8) | 5 | VAL A 31ALA A 167VAL A 76GLY A 78ALA A 77 | None | 1.06A | 5kirA-5ffnA:undetectable | 5kirA-5ffnA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5z | MHC CLASS I ANTIGEN (Ctenopharyngodonidella) |
no annotation | 5 | GLN A 152TYR A 97VAL A 65GLY A 68ALA A 69 | None | 1.09A | 5kirA-5h5zA:undetectable | 5kirA-5h5zA:9.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | HIS A 90GLN A 192VAL A 349LEU A 352TYR A 355TRP A 387ALA A 516VAL A 523ALA A 527SER A 530LEU A 531 | NoneNoneID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 (-3.8A)COH A 602 (-4.5A)NoneID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.68A | 5kirA-5ikrA:63.0 | 5kirA-5ikrA:99.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | HIS A 90GLN A 192VAL A 349LEU A 352TYR A 355TRP A 387ALA A 516VAL A 523GLY A 526ALA A 527LEU A 531 | NoneNoneID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 (-3.8A)COH A 602 (-4.5A)NoneID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A) | 0.45A | 5kirA-5ikrA:63.0 | 5kirA-5ikrA:99.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kei | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 266ALA A 106GLY A 273ALA A 274LEU A 243 | None | 1.06A | 5kirA-5keiA:0.6 | 5kirA-5keiA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | PROTEASOME SUBUNITBETA TYPE-2 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU J 4TYR J 117GLY J 135ALA J 136LEU J 140 | None | 1.02A | 5kirA-5m32J:undetectable | 5kirA-5m32J:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | VAL A4309LEU A4312TRP A4320GLY A4152ALA A4155 | None | 1.03A | 5kirA-5nugA:undetectable | 5kirA-5nugA:7.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0s | GLUCOSYLCERAMIDASE (Thermoanaerobacteriumxylanolyticum) |
PF04685(DUF608)PF12215(Glyco_hydr_116N)PF17168(DUF5127) | 5 | LEU A 411TYR A 412ALA A 406GLY A 457LEU A 439 | None | 0.93A | 5kirA-5o0sA:undetectable | 5kirA-5o0sA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2o | J30 CCH (Thermobacilluscomposti) |
no annotation | 5 | VAL A 400LEU A 401GLY A 416ALA A 418LEU A 421 | None | 1.08A | 5kirA-5u2oA:undetectable | 5kirA-5u2oA:9.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u39 | UDP-3-O-ACYL-N-ACETYLGLUCOSAMINEDEACETYLASE (Pseudomonasaeruginosa) |
PF03331(LpxC) | 6 | LEU A 86ALA A 117GLY A 108ALA A 107SER A 186LEU A 240 | None | 1.29A | 5kirA-5u39A:undetectable | 5kirA-5u39A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uld | TRANSPORTER, NADCFAMILY (Vibrio cholerae) |
PF00939(Na_sulph_symp) | 5 | LEU A 270VAL A 295GLY A 298ALA A 299LEU A 303 | None | 0.79A | 5kirA-5uldA:undetectable | 5kirA-5uldA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uxb | MACROLIDE2'-PHOSPHOTRANSFERASE MPHH (Brachybacteriumfaecium) |
PF01636(APH) | 5 | VAL A 127LEU A 130TRP A 215ALA A 138GLY A 195 | None | 1.09A | 5kirA-5uxbA:undetectable | 5kirA-5uxbA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vwm | UDP-3-O-ACYL-N-ACETYLGLUCOSAMINEDEACETYLASE (Pseudomonasaeruginosa) |
PF03331(LpxC) | 5 | LEU A 86GLY A 108ALA A 107SER A 186LEU A 240 | NoneEDO A 405 (-3.4A)NoneEDO A 405 (-2.8A)None | 1.07A | 5kirA-5vwmA:undetectable | 5kirA-5vwmA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wqk | SULFURTRANSFERASE (Mus musculus) |
PF00581(Rhodanese) | 5 | LEU A 232VAL A 257GLY A 260ALA A 261SER A 264 | None | 1.09A | 5kirA-5wqkA:undetectable | 5kirA-5wqkA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y09 | PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
no annotation | 5 | ALA A 565VAL A 540GLY A 538ALA A 537LEU A 586 | None | 1.08A | 5kirA-5y09A:undetectable | 5kirA-5y09A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yl7 | PSEUDOALTEROMONASARCTICA PAMC 21717 (Pseudoalteromonasarctica) |
no annotation | 5 | VAL A 181ALA A 343VAL A 248GLY A 250ALA A 249 | None | 1.07A | 5kirA-5yl7A:undetectable | 5kirA-5yl7A:7.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yvs | ALCOHOLDEHYDROGENASE (candidatedivison MSBL1archaeonSCGC-AAA259E19) |
no annotation | 5 | ALA A 160VAL A 77GLY A 80ALA A 81LEU A 85 | None | 0.77A | 5kirA-5yvsA:undetectable | 5kirA-5yvsA:9.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zl9 | CHITINASE AB (Serratiamarcescens) |
no annotation | 5 | VAL A 160ALA A 520GLY A 559ALA A 560SER A 156 | NoneGOL A 701 (-3.4A)NoneNoneNone | 1.02A | 5kirA-5zl9A:undetectable | 5kirA-5zl9A:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez8 | HUNTINGTIN (Homo sapiens) |
no annotation | 5 | VAL A2782ALA A2745GLY A2777ALA A2778LEU A2767 | None | 1.09A | 5kirA-6ez8A:undetectable | 5kirA-6ez8A:7.45 |