SIMILAR PATTERNS OF AMINO ACIDS FOR 5KIR_A_RCXA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 1BH  A 300 ( 3.7A)
None
None
None
None
 1.01A 5kirA-1bh6A:
undetectable		 5kirA-1bh6A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  36
LEU A  37
ALA A  76
GLY A  47
LEU A 362
 None
 1.03A 5kirA-1bkhA:
0.0		 5kirA-1bkhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 XE  A 281 ( 3.9A)
None
None
None
None
 1.01A 5kirA-1c3lA:
undetectable		 5kirA-1c3lA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.30A 5kirA-1ebvA:
58.4		 5kirA-1ebvA:
63.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 168
TRP A 195
ALA A 204
VAL A 163
ALA A 164
 None
 1.08A 5kirA-1gwcA:
1.6		 5kirA-1gwcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.04A 5kirA-1jioA:
undetectable		 5kirA-1jioA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 5kirA-1jy1A:
0.0		 5kirA-1jy1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 VAL A 241
TYR A 305
ALA A 328
SER A 237
LEU A 232
 None
 1.08A 5kirA-1krhA:
0.0		 5kirA-1krhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  51
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.04A 5kirA-1n61C:
0.0		 5kirA-1n61C:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
 None
NDP  A1325 (-3.5A)
NDP  A1325 (-4.0A)
None
None
 1.06A 5kirA-1o8cA:
undetectable		 5kirA-1o8cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A 642
ALA A 638
VAL A 625
GLY A 623
ALA A 621
 None
 0.94A 5kirA-1ofeA:
undetectable		 5kirA-1ofeA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		6 VAL A  40
LEU A  41
ALA A  68
GLY A 250
ALA A  31
LEU A 282
 None
 1.09A 5kirA-1qhgA:
undetectable		 5kirA-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		6 VAL A  40
LEU A  41
ALA A  68
GLY B 250
ALA A  31
LEU B 282
 None
 1.10A 5kirA-1qhhA:
undetectable		 5kirA-1qhhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 VAL A  46
ALA A  38
VAL A  14
GLY A  17
LEU A 219
 VAL  A  46 ( 0.6A)
ALA  A  38 ( 0.0A)
VAL  A  14 ( 0.6A)
GLY  A  17 ( 0.0A)
LEU  A 219 ( 0.6A)
 0.89A 5kirA-1rrvA:
undetectable		 5kirA-1rrvA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
ALA A  93
VAL A 101
GLY A  80
ALA A  81
 None
 1.02A 5kirA-1sc6A:
undetectable		 5kirA-1sc6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.06A 5kirA-1sezA:
undetectable		 5kirA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 0.98A 5kirA-1uaaA:
undetectable		 5kirA-1uaaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		5 VAL A 127
LEU A  79
ALA A 377
ALA A  50
LEU A 113
 None
 0.84A 5kirA-1uz4A:
undetectable		 5kirA-1uz4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 0.99A 5kirA-2arkA:
undetectable		 5kirA-2arkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 0.95A 5kirA-2cb1A:
undetectable		 5kirA-2cb1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		5 LEU A 442
ALA A 410
VAL A 427
GLY A 429
ALA A 428
 None
 1.08A 5kirA-2d7sA:
undetectable		 5kirA-2d7sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
 PMS  A 601 ( 3.8A)
None
None
None
None
 0.92A 5kirA-2gkoA:
undetectable		 5kirA-2gkoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 VAL A  70
ALA A  98
GLY A 142
ALA A 143
LEU A 110
 None
 1.08A 5kirA-2i34A:
undetectable		 5kirA-2i34A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4k GENERAL STRESS
PROTEIN 13

(Bacillus
subtilis) 		PF00575
(S1) 		5 ALA A  78
VAL A  35
GLY A  22
ALA A  23
LEU A  18
 None
 0.89A 5kirA-2k4kA:
undetectable		 5kirA-2k4kA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		6 VAL A  40
LEU A  41
ALA A  68
GLY A 250
ALA A  31
LEU A 282
 None
 1.10A 5kirA-2pjrA:
undetectable		 5kirA-2pjrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 VAL A 102
LEU A 101
ALA A  66
VAL A  73
GLY A 115
LEU A 143
 None
 1.41A 5kirA-2pwzA:
undetectable		 5kirA-2pwzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		6 VAL A 176
LEU A 179
ALA A 198
GLY A 216
ALA A 416
LEU A 417
 None
 1.49A 5kirA-2wdwA:
undetectable		 5kirA-2wdwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 1.05A 5kirA-2xn8A:
undetectable		 5kirA-2xn8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.90A 5kirA-2yr5A:
undetectable		 5kirA-2yr5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 108
ALA A 340
GLY A 127
ALA A 126
LEU A 141
 None
 0.98A 5kirA-3a71A:
undetectable		 5kirA-3a71A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		5 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.08A 5kirA-3aamA:
undetectable		 5kirA-3aamA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		6 HIS A 919
VAL A 633
LEU A 630
TRP A 581
ALA A 552
LEU A 550
 None
 1.35A 5kirA-3bgaA:
0.5		 5kirA-3bgaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.00A 5kirA-3d43A:
undetectable		 5kirA-3d43A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		6 HIS A 895
VAL A 609
LEU A 606
TRP A 557
ALA A 528
LEU A 526
 None
 1.38A 5kirA-3decA:
undetectable		 5kirA-3decA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 6 ALA A2023
VAL A2062
GLY A2065
ALA A2066
SER A2068
LEU A2069
 None
 1.27A 5kirA-3dyjA:
undetectable		 5kirA-3dyjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 5 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 1.07A 5kirA-3fyqA:
undetectable		 5kirA-3fyqA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 457
ALA A 495
VAL A 113
GLY A 112
ALA A 111
 HBX  A 530 (-4.3A)
None
FAD  A 522 (-3.7A)
FAD  A 522 (-3.9A)
FAD  A 522 ( 3.0A)
 0.93A 5kirA-3gdnA:
undetectable		 5kirA-3gdnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.79A 5kirA-3h6eA:
undetectable		 5kirA-3h6eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 339
LEU A 379
ALA A 330
VAL A 381
GLY A 384
 None
 0.95A 5kirA-3hz6A:
undetectable		 5kirA-3hz6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		6 VAL A  38
LEU A  39
ALA A  66
GLY A 247
ALA A  29
LEU A 279
 None
 1.10A 5kirA-3lfuA:
undetectable		 5kirA-3lfuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls1 SLL1638 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05757
(PsbQ) 		5 ALA A  51
GLY A  88
ALA A  90
SER A  92
LEU A  93
 None
 1.09A 5kirA-3ls1A:
undetectable		 5kirA-3ls1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 HIS A 244
LEU A 102
VAL A  55
GLY A  53
SER A 118
 None
 0.98A 5kirA-3mpiA:
undetectable		 5kirA-3mpiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS

(Streptococcus
pneumoniae) 		PF02302
(PTS_IIB) 		5 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 1.08A 5kirA-3nbmA:
undetectable		 5kirA-3nbmA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
 None
NAP  A 330 (-3.5A)
NAP  A 330 (-3.8A)
None
None
 1.08A 5kirA-3nx4A:
undetectable		 5kirA-3nx4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 5 LEU A  90
VAL A 140
ALA A 144
SER A 147
LEU A 268
 None
 0.94A 5kirA-3ocdA:
undetectable		 5kirA-3ocdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 458
ALA A 496
VAL A 113
GLY A 112
ALA A 111
 None
None
FAD  A 773 (-3.7A)
FAD  A 773 (-3.9A)
FAD  A 773 (-3.0A)
 0.98A 5kirA-3redA:
undetectable		 5kirA-3redA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		5 VAL A 291
LEU A 294
ALA A 300
VAL A 132
GLY A 134
 None
 0.97A 5kirA-3s99A:
undetectable		 5kirA-3s99A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 LEU A 663
ALA A 658
VAL A 622
GLY A 624
LEU A 629
 None
 0.87A 5kirA-3slkA:
undetectable		 5kirA-3slkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 VAL A  37
ALA A 204
VAL A 109
GLY A 111
ALA A 110
 None
 1.09A 5kirA-3ti7A:
undetectable		 5kirA-3ti7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT

(Mycobacterium
tuberculosis) 		PF02861
(Clp_N) 		5 LEU A 110
ALA A  95
ALA A  45
SER A  48
LEU A  49
 None
 0.79A 5kirA-3wdbA:
0.8		 5kirA-3wdbA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		5 GLN A 194
VAL A 188
LEU A 191
ALA A 300
LEU A 267
 None
 1.06A 5kirA-4etzA:
undetectable		 5kirA-4etzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3m BH0337 PROTEIN

(Bacillus
halodurans) 		PF09704
(Cas_Cas5d) 		5 VAL A 144
LEU A   9
GLY A  40
ALA A  42
SER A  44
 None
 0.94A 5kirA-4f3mA:
undetectable		 5kirA-4f3mA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU N 290
ALA N 401
ALA N 329
SER N 332
LEU N 333
 None
 1.09A 5kirA-4heaN:
undetectable		 5kirA-4heaN:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.92A 5kirA-4j9uA:
3.1		 5kirA-4j9uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcd MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 2) 		PF00718
(Polyoma_coat) 		5 ALA A 255
VAL A 111
GLY A 113
SER A 116
LEU A 117
 None
 1.02A 5kirA-4jcdA:
undetectable		 5kirA-4jcdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 VAL A 923
LEU A 926
VAL A 961
ALA A 965
LEU A 997
 None
 1.06A 5kirA-4k0eA:
0.6		 5kirA-4k0eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.89A 5kirA-4k3jA:
undetectable		 5kirA-4k3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 VAL A  91
ALA A 235
VAL A 130
GLY A 132
ALA A 131
 None
 1.07A 5kirA-4kg7A:
undetectable		 5kirA-4kg7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.07A 5kirA-4ky0A:
undetectable		 5kirA-4ky0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 VAL A 255
ALA A 404
VAL A 310
GLY A 312
ALA A 311
 None
 1.09A 5kirA-4mzdA:
undetectable		 5kirA-4mzdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1

(Mycobacterium
tuberculosis) 		PF00575
(S1) 		5 ALA A 365
VAL A 321
GLY A 308
ALA A 309
LEU A 304
 None
 1.02A 5kirA-4nngA:
undetectable		 5kirA-4nngA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.81A 5kirA-4o1mA:
undetectable		 5kirA-4o1mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		5 VAL A 149
ALA A 112
VAL A 157
GLY A 159
ALA A 160
 None
 1.06A 5kirA-4owtA:
undetectable		 5kirA-4owtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.07A 5kirA-4oyeA:
undetectable		 5kirA-4oyeA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 GLN A 139
LEU A 355
TRP A 334
ALA A 135
GLY A 328
 None
 1.09A 5kirA-4pe3A:
undetectable		 5kirA-4pe3A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 HIS A  90
GLN A 193
VAL A 350
LEU A 353
TYR A 356
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
SER A 531
LEU A 532
 None
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.25A 5kirA-4ph9A:
62.4		 5kirA-4ph9A:
87.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		5 ALA A 267
VAL A 122
GLY A 124
SER A 127
LEU A 128
 None
EDO  A 403 (-4.4A)
None
None
None
 1.06A 5kirA-4potA:
undetectable		 5kirA-4potA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 HIS A 249
VAL A 159
LEU A 158
GLY A 118
LEU A 108
 None
 1.01A 5kirA-4psdA:
undetectable		 5kirA-4psdA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		5 ALA A  74
VAL A  97
GLY A  95
SER A  10
LEU A 291
 None
 1.09A 5kirA-4q60A:
undetectable		 5kirA-4q60A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		5 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 0.98A 5kirA-4r86A:
undetectable		 5kirA-4r86A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 HIS A 253
VAL A 219
LEU A 124
GLY A 137
ALA A 232
 None
 0.99A 5kirA-4rncA:
undetectable		 5kirA-4rncA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 0.83A 5kirA-4rt6A:
undetectable		 5kirA-4rt6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 LEU B 232
TYR B 213
VAL B 237
GLY A 150
ALA A 149
 None
 1.04A 5kirA-4tqvB:
undetectable		 5kirA-4tqvB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.94A 5kirA-4us5A:
0.0		 5kirA-4us5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.80A 5kirA-4zqbA:
undetectable		 5kirA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.06A 5kirA-5a4jA:
undetectable		 5kirA-5a4jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azs OUTER MEMBRANE
PROTEIN OPRJ

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 ALA A 345
GLY A 286
ALA A 287
SER A 129
LEU A 130
 None
 1.02A 5kirA-5azsA:
undetectable		 5kirA-5azsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.96A 5kirA-5dotA:
undetectable		 5kirA-5dotA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 VAL A 107
LEU A 108
ALA A 132
GLY A 127
LEU A  90
 None
None
GOL  A 401 (-3.7A)
GOL  A 402 ( 4.4A)
None
 0.99A 5kirA-5et1A:
undetectable		 5kirA-5et1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 158
VAL A  72
GLY A  74
ALA A  73
LEU A  91
 None
None
5VV  A   1 ( 4.8A)
None
None
 0.93A 5kirA-5fbzA:
undetectable		 5kirA-5fbzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 167
VAL A  76
GLY A  78
ALA A  77
LEU A 100
 None
 0.98A 5kirA-5ffnA:
undetectable		 5kirA-5ffnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 VAL A  31
ALA A 167
VAL A  76
GLY A  78
ALA A  77
 None
 1.06A 5kirA-5ffnA:
undetectable		 5kirA-5ffnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5z MHC CLASS I ANTIGEN

(Ctenopharyngodon
idella) 		no annotation 5 GLN A 152
TYR A  97
VAL A  65
GLY A  68
ALA A  69
 None
 1.09A 5kirA-5h5zA:
undetectable		 5kirA-5h5zA:
9.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
ALA A 516
VAL A 523
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.68A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.45A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 266
ALA A 106
GLY A 273
ALA A 274
LEU A 243
 None
 1.06A 5kirA-5keiA:
0.6		 5kirA-5keiA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.02A 5kirA-5m32J:
undetectable		 5kirA-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.03A 5kirA-5nugA:
undetectable		 5kirA-5nugA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 LEU A 411
TYR A 412
ALA A 406
GLY A 457
LEU A 439
 None
 0.93A 5kirA-5o0sA:
undetectable		 5kirA-5o0sA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 VAL A 400
LEU A 401
GLY A 416
ALA A 418
LEU A 421
 None
 1.08A 5kirA-5u2oA:
undetectable		 5kirA-5u2oA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		6 LEU A  86
ALA A 117
GLY A 108
ALA A 107
SER A 186
LEU A 240
 None
 1.29A 5kirA-5u39A:
undetectable		 5kirA-5u39A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.79A 5kirA-5uldA:
undetectable		 5kirA-5uldA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 VAL A 127
LEU A 130
TRP A 215
ALA A 138
GLY A 195
 None
 1.09A 5kirA-5uxbA:
undetectable		 5kirA-5uxbA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 LEU A  86
GLY A 108
ALA A 107
SER A 186
LEU A 240
 None
EDO  A 405 (-3.4A)
None
EDO  A 405 (-2.8A)
None
 1.07A 5kirA-5vwmA:
undetectable		 5kirA-5vwmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.09A 5kirA-5wqkA:
undetectable		 5kirA-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.08A 5kirA-5y09A:
undetectable		 5kirA-5y09A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ALA A 343
VAL A 248
GLY A 250
ALA A 249
 None
 1.07A 5kirA-5yl7A:
undetectable		 5kirA-5yl7A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 160
VAL A  77
GLY A  80
ALA A  81
LEU A  85
 None
 0.77A 5kirA-5yvsA:
undetectable		 5kirA-5yvsA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 VAL A 160
ALA A 520
GLY A 559
ALA A 560
SER A 156
 None
GOL  A 701 (-3.4A)
None
None
None
 1.02A 5kirA-5zl9A:
undetectable		 5kirA-5zl9A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 VAL A2782
ALA A2745
GLY A2777
ALA A2778
LEU A2767
 None
 1.09A 5kirA-6ez8A:
undetectable		 5kirA-6ez8A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0r PHOSDUCIN

(Bos taurus) 		PF02114
(Phosducin) 		3 ARG P 110
ILE P 133
PHE P 107
 None
 0.69A 5kirA-1a0rP:
0.0		 5kirA-1a0rP:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvo TRANSCRIPTION FACTOR
GAMBIF1

(Anopheles
gambiae) 		PF00554
(RHD_DNA_bind) 		3 ARG A  64
ILE A 149
PHE A  63
 None
 0.44A 5kirA-1bvoA:
undetectable		 5kirA-1bvoA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 ARG A 104
ILE A 115
PHE A 105
 None
 0.74A 5kirA-1do5A:
0.0		 5kirA-1do5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5p APHRODISIN

(Mesocricetus
auratus) 		PF00061
(Lipocalin) 		3 ARG A  34
ILE A  47
PHE A  33
 None
 0.71A 5kirA-1e5pA:
undetectable		 5kirA-1e5pA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ARG A  72
ILE A 103
PHE A  73
 None
 0.73A 5kirA-1ethA:
0.0		 5kirA-1ethA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gji C-REL PROTO-ONCOGENE
PROTEIN

(Gallus gallus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG A  23
ILE A 106
PHE A  22
 None
 0.69A 5kirA-1gjiA:
0.0		 5kirA-1gjiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ARG A 263
ILE A 317
PHE A 369
 None
 0.73A 5kirA-1gytA:
0.0		 5kirA-1gytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ARG A 348
ILE A 399
PHE A 268
 None
 0.69A 5kirA-1hn0A:
1.4		 5kirA-1hn0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqg FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF09163
(Form-deh_trans)
PF12800
(Fer4_4)
PF13247
(Fer4_11) 		3 ARG B  81
ILE B  95
PHE B  82
 None
 0.73A 5kirA-1kqgB:
0.0		 5kirA-1kqgB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ARG B  71
ILE B 102
PHE B  72
 None
 0.75A 5kirA-1lpbB:
undetectable		 5kirA-1lpbB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 ARG A 133
ILE A 136
PHE A 131
 None
 0.76A 5kirA-1o5tA:
undetectable		 5kirA-1o5tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 175
ILE A 147
PHE A 174
 None
 0.76A 5kirA-1pg5A:
undetectable		 5kirA-1pg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		3 ARG B  95
ILE B  83
PHE B  94
 None
 0.76A 5kirA-1r4nB:
undetectable		 5kirA-1r4nB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		3 ARG A 688
ILE A 655
PHE A 660
 None
 0.69A 5kirA-1ru3A:
undetectable		 5kirA-1ru3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 260
ILE A 258
PHE A 259
 None
 0.70A 5kirA-1rxwA:
undetectable		 5kirA-1rxwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG P  59
ILE P 142
PHE P  58
 None
 0.64A 5kirA-1svcP:
undetectable		 5kirA-1svcP:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ARG C 142
ILE C 114
PHE C 143
 None
 0.71A 5kirA-1sxjC:
undetectable		 5kirA-1sxjC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 ARG A 612
ILE A 588
PHE A 621
 None
 0.65A 5kirA-1uusA:
undetectable		 5kirA-1uusA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 ARG B 356
ILE B 439
PHE B 355
 None
 0.70A 5kirA-1vkxB:
undetectable		 5kirA-1vkxB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9w BH0236 PROTEIN

(Bacillus
halodurans) 		PF03422
(CBM_6) 		3 ARG A  58
ILE A 111
PHE A  56
 None
 0.69A 5kirA-1w9wA:
undetectable		 5kirA-1w9wA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgh UBIQUITIN-LIKE 3

(Mus musculus) 		PF13881
(Rad60-SLD_2) 		3 ARG A  72
ILE A  68
PHE A  73
 None
 0.61A 5kirA-1wghA:
undetectable		 5kirA-1wghA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A 158
ILE A 153
PHE A 157
 None
 0.62A 5kirA-1x8vA:
undetectable		 5kirA-1x8vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 ARG A 304
ILE A 245
PHE A 311
 None
 0.76A 5kirA-1xdvA:
undetectable		 5kirA-1xdvA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2y CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00385
(Chromo) 		3 ARG C  18
ILE C  62
PHE C  19
 None
 0.76A 5kirA-2b2yC:
undetectable		 5kirA-2b2yC:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		3 ARG A 184
ILE A 182
PHE A 183
 None
 0.53A 5kirA-2bmfA:
undetectable		 5kirA-2bmfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		3 ARG C  65
ILE C  35
PHE C  66
 None
 0.68A 5kirA-2bruC:
undetectable		 5kirA-2bruC:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		3 ARG A 141
ILE A   5
PHE A 140
 None
 0.54A 5kirA-2gmyA:
undetectable		 5kirA-2gmyA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5h HYPOTHETICAL PROTEIN
AF1531

(Archaeoglobus
fulgidus) 		PF04919
(DUF655) 		3 ARG A 150
ILE A 161
PHE A 119
 None
 0.73A 5kirA-2i5hA:
undetectable		 5kirA-2i5hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		3 ARG A1059
ILE A1047
PHE A1060
 None
 0.57A 5kirA-2iphA:
undetectable		 5kirA-2iphA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		3 ARG A 302
ILE A 311
PHE A 189
 None
 0.66A 5kirA-2nq2A:
undetectable		 5kirA-2nq2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		3 ARG A  35
ILE A 118
PHE A  34
 None
 0.53A 5kirA-2o61A:
undetectable		 5kirA-2o61A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ARG A 216
ILE A 107
PHE A 217
 None
 0.70A 5kirA-2vmfA:
undetectable		 5kirA-2vmfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ARG B 581
ILE B 506
PHE B 582
 None
 0.72A 5kirA-2w55B:
undetectable		 5kirA-2w55B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 3 ARG A 258
ILE A 232
PHE A 257
 None
 0.57A 5kirA-2wb7A:
undetectable		 5kirA-2wb7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 ARG A 431
ILE A 448
PHE A 457
 None
 0.69A 5kirA-2x49A:
0.0		 5kirA-2x49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		3 ARG A 497
ILE A 514
PHE A 498
 None
 0.56A 5kirA-3a0rA:
0.2		 5kirA-3a0rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0v SENSOR PROTEIN

(Thermotoga
maritima) 		PF00989
(PAS) 		3 ARG A 497
ILE A 514
PHE A 498
 None
 0.51A 5kirA-3a0vA:
undetectable		 5kirA-3a0vA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ARG A 117
ILE A 112
PHE A 142
 None
 0.44A 5kirA-3bazA:
undetectable		 5kirA-3bazA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 3 ARG A 180
ILE A 188
PHE A 179
 None
 0.57A 5kirA-3c4aA:
undetectable		 5kirA-3c4aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chm COP9 SIGNALOSOME
COMPLEX SUBUNIT 7

(Arabidopsis
thaliana) 		PF01399
(PCI) 		3 ARG A 160
ILE A 140
PHE A  40
 None
 0.54A 5kirA-3chmA:
undetectable		 5kirA-3chmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq3 INORGANIC
PYROPHOSPHATASE:BACT
ERIAL/ARCHAEAL
INORGANIC
PYROPHOSPHATASE

(Brucella
abortus) 		PF00719
(Pyrophosphatase) 		3 ARG A  44
ILE A  29
PHE A  45
 None
 0.58A 5kirA-3fq3A:
undetectable		 5kirA-3fq3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG A 685
ILE A 652
PHE A 657
 None
 0.69A 5kirA-3gitA:
undetectable		 5kirA-3gitA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 ARG A   5
ILE A 149
PHE A   4
 None
 0.73A 5kirA-3h39A:
undetectable		 5kirA-3h39A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		3 ARG A 337
ILE A 339
PHE A 340
 None
 0.74A 5kirA-3h5cA:
undetectable		 5kirA-3h5cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		3 ARG A 338
ILE A   5
PHE A 339
 None
 0.68A 5kirA-3hfqA:
undetectable		 5kirA-3hfqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hib PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF02889
(Sec63) 		3 ARG A1995
ILE A1997
PHE A2000
 None
 0.62A 5kirA-3hibA:
undetectable		 5kirA-3hibA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 ARG A 175
ILE A 208
PHE A 174
 None
 0.61A 5kirA-3i04A:
undetectable		 5kirA-3i04A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE

(Bartonella
henselae) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		3 ARG A 189
ILE A 150
PHE A 203
 None
 0.73A 5kirA-3ijpA:
undetectable		 5kirA-3ijpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ARG A1691
ILE A1584
PHE A1692
 None
 0.75A 5kirA-3jb9A:
undetectable		 5kirA-3jb9A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ARG A 676
ILE A 673
PHE A 675
 None
 0.68A 5kirA-3karA:
undetectable		 5kirA-3karA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		3 ARG A 380
ILE A 375
PHE A 379
 None
 0.74A 5kirA-3kv4A:
undetectable		 5kirA-3kv4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 ARG A  44
ILE A  15
PHE A  45
 None
 0.75A 5kirA-3lq0A:
undetectable		 5kirA-3lq0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 ARG A  96
ILE A  94
PHE A  95
 None
 0.59A 5kirA-3ml0A:
undetectable		 5kirA-3ml0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p39 NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 ARG A 135
ILE A 132
PHE A 133
 None
 0.58A 5kirA-3p39A:
undetectable		 5kirA-3p39A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 ARG A 336
ILE A 284
PHE A 337
 None
 0.61A 5kirA-3pr4A:
undetectable		 5kirA-3pr4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd4 UNCHARACTERIZED
PROTEIN

(Proteus penneri) 		PF10694
(DUF2500) 		3 ARG A  78
ILE A  56
PHE A  79
 None
 0.70A 5kirA-3rd4A:
undetectable		 5kirA-3rd4A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 ARG A  59
ILE A  80
PHE A  60
 None
 0.75A 5kirA-3rl3A:
undetectable		 5kirA-3rl3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		3 ARG A 303
ILE A 288
PHE A 302
 None
 0.76A 5kirA-3s3rA:
undetectable		 5kirA-3s3rA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		3 ARG A 657
ILE A 654
PHE A 656
 None
 0.74A 5kirA-3t0qA:
undetectable		 5kirA-3t0qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0i PROBABLE
FAD-BINDING,
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Brucella
abortus) 		PF12900
(Pyridox_ox_2) 		3 ARG A  39
ILE A  15
PHE A  40
 None
 0.59A 5kirA-3u0iA:
undetectable		 5kirA-3u0iA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ARG A1288
ILE A1286
PHE A1287
 None
 0.75A 5kirA-3ummA:
undetectable		 5kirA-3ummA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uws HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF03415
(Peptidase_C11) 		3 ARG B 312
ILE B 314
PHE B 313
 None
 0.72A 5kirA-3uwsB:
undetectable		 5kirA-3uwsB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		3 ARG A 281
ILE A 253
PHE A 278
 None
 0.73A 5kirA-3wdqA:
undetectable		 5kirA-3wdqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 ARG A 515
ILE A 485
PHE A 503
 None
 0.73A 5kirA-3zxlA:
undetectable		 5kirA-3zxlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 ARG A 159
ILE A 165
PHE A 178
 None
 0.45A 5kirA-4aigA:
undetectable		 5kirA-4aigA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ARG A 960
ILE A 985
PHE A1601
 None
 0.72A 5kirA-4amcA:
undetectable		 5kirA-4amcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		3 ARG A 523
ILE A 491
PHE A 475
 None
 0.76A 5kirA-4amfA:
undetectable		 5kirA-4amfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ARG A 508
ILE A 514
PHE A 515
 None
 0.71A 5kirA-4areA:
undetectable		 5kirA-4areA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG A 186
ILE A 268
PHE A 182
 None
 0.75A 5kirA-4bziA:
1.1		 5kirA-4bziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF14554
(VEGF_C) 		3 ARG A  61
ILE A 127
PHE A  62
 None
 0.75A 5kirA-4deqA:
undetectable		 5kirA-4deqA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 337
ILE A 357
PHE A 336
 None
 0.72A 5kirA-4dwdA:
undetectable		 5kirA-4dwdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hku TETR TRANSCRIPTIONAL
REGULATOR

(Listeria
monocytogenes) 		PF00440
(TetR_N) 		3 ARG A  65
ILE A  67
PHE A  68
 None
 0.75A 5kirA-4hkuA:
1.6		 5kirA-4hkuA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		3 ARG A  79
ILE A  81
PHE A 118
 None
 0.74A 5kirA-4i8qA:
undetectable		 5kirA-4i8qA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		3 ARG A 440
ILE A 448
PHE A  21
 None
 0.55A 5kirA-4k35A:
undetectable		 5kirA-4k35A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 ARG A  57
ILE A 162
PHE A  58
 None
 0.76A 5kirA-4ow8A:
undetectable		 5kirA-4ow8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 ARG A1797
ILE A1788
PHE A1695
 None
 0.73A 5kirA-4p1tA:
undetectable		 5kirA-4p1tA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 ARG A 514
ILE A 518
PHE A 519
 None
 0.21A 5kirA-4ph9A:
62.4		 5kirA-4ph9A:
87.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A 412
ILE A 255
PHE A 413
 None
 0.62A 5kirA-4qavA:
undetectable		 5kirA-4qavA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A 159
ILE A  96
PHE A 160
 None
 0.68A 5kirA-4ruhA:
undetectable		 5kirA-4ruhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uow TITIN

(Homo sapiens) 		PF07679
(I-set) 		3 ARG 1  57
ILE 1  69
PHE 1  56
 None
 0.69A 5kirA-4uow1:
undetectable		 5kirA-4uow1:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywk CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A  94
ILE A  44
PHE A  95
 None
 0.69A 5kirA-4ywkA:
undetectable		 5kirA-4ywkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A  94
ILE A  44
PHE A  95
 None
 0.76A 5kirA-4ywlA:
undetectable		 5kirA-4ywlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		3 ARG A 415
ILE A 420
PHE A 416
 None
 0.76A 5kirA-5ddbA:
0.0		 5kirA-5ddbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		3 ARG A 159
ILE A 175
PHE A 160
 None
 0.70A 5kirA-5dlkA:
undetectable		 5kirA-5dlkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 ARG A 645
ILE A 649
PHE A 644
 None
 0.74A 5kirA-5f0oA:
0.7		 5kirA-5f0oA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h28 OXYSTEROL-BINDING
PROTEIN HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF13637
(Ank_4) 		3 ARG A 226
ILE A 271
PHE A 224
 None
 0.74A 5kirA-5h28A:
undetectable		 5kirA-5h28A:
16.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 ARG A 513
ILE A 517
PHE A 518
 None
 0.15A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1

(Chaetomium
thermophilum) 		PF03164
(Mon1) 		3 ARG A 275
ILE A 289
PHE A 276
 None
 0.50A 5kirA-5lddA:
undetectable		 5kirA-5lddA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 3 ARG A 378
ILE A 376
PHE A 377
 None
 0.61A 5kirA-5mjsA:
undetectable		 5kirA-5mjsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21

(Kluyveromyces
lactis) 		no annotation 3 ARG A 247
ILE A 253
PHE A 246
 None
 0.75A 5kirA-5mu3A:
undetectable		 5kirA-5mu3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		3 ARG C 459
ILE C 456
PHE C 458
 None
 0.73A 5kirA-5nd7C:
undetectable		 5kirA-5nd7C:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 ARG T2445
ILE T 982
PHE T2480
 None
 0.75A 5kirA-5ojsT:
undetectable		 5kirA-5ojsT:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 365
ILE A 378
PHE A 364
 None
 0.60A 5kirA-5szqA:
undetectable		 5kirA-5szqA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 ARG C 813
ILE C 815
PHE C 816
 None
 0.67A 5kirA-5tw1C:
undetectable		 5kirA-5tw1C:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 ARG A 353
ILE A 235
PHE A 277
 None
 0.67A 5kirA-5vi6A:
undetectable		 5kirA-5vi6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		3 ARG A 210
ILE A 268
PHE A 254
 None
 0.76A 5kirA-5vpqA:
undetectable		 5kirA-5vpqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 3 ARG A 217
ILE A  12
PHE A 216
 C7V  A 501 (-3.8A)
None
C7V  A 501 (-3.2A)
 0.66A 5kirA-6b0tA:
undetectable		 5kirA-6b0tA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 3 ARG A 409
ILE A 379
PHE A 408
 None
 0.68A 5kirA-6b9sA:
undetectable		 5kirA-6b9sA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 3 ARG B 182
ILE B 167
PHE B 181
 None
 0.63A 5kirA-6eysB:
undetectable		 5kirA-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		no annotation 3 ARG A 396
ILE A 398
PHE A 394
 None
 0.72A 5kirA-6f9sA:
undetectable		 5kirA-6f9sA:
8.04