SIMILAR PATTERNS OF AMINO ACIDS FOR 5KI6_A_IPHA903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 CYH A 108
GLN A  92
PRO A  91
ILE A  60
 None
 1.13A 5ki6A-1ciaA:
0.0		 5ki6A-1ciaA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ARG A 255
CYH A 216
GLN A  87
ILE A 220
 None
 1.50A 5ki6A-1l8kA:
1.8		 5ki6A-1l8kA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		4 ARG A  66
GLN A  67
PRO A  51
ILE A  64
 None
 1.28A 5ki6A-1mg7A:
1.4		 5ki6A-1mg7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ARG A 172
CYH A 214
GLN A 210
ILE A 491
 None
 1.29A 5ki6A-1o0sA:
5.2		 5ki6A-1o0sA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19

(Homo sapiens) 		PF04969
(CS) 		4 CYH A  94
GLN A  93
PRO A  91
ILE A  89
 None
 1.22A 5ki6A-1wh0A:
undetectable		 5ki6A-1wh0A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ARG A 881
CYH A 842
GLN A 718
ILE A 846
 None
 1.49A 5ki6A-2b49A:
0.0		 5ki6A-2b49A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 CYH A  67
GLN A  63
PRO A  50
ILE A  51
 None
 1.36A 5ki6A-2d5rA:
undetectable		 5ki6A-2d5rA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 CYH A  50
GLN A  52
PRO A  14
ILE A  87
 None
 1.43A 5ki6A-2i44A:
undetectable		 5ki6A-2i44A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ARG A 891
CYH A 852
GLN A 727
ILE A 856
 None
SO4  A   1 ( 4.2A)
None
None
 1.49A 5ki6A-2i75A:
0.0		 5ki6A-2i75A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ARG A 567
GLN A 538
PRO A 541
ILE A 555
 None
 1.49A 5ki6A-2jjdA:
2.3		 5ki6A-2jjdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzk UNCHARACTERIZED
PROTEIN YOL083W

(Saccharomyces
cerevisiae) 		PF12744
(ATG19_autophagy) 		4 CYH A 277
GLN A 326
PRO A 274
ILE A 331
 None
 1.39A 5ki6A-2kzkA:
undetectable		 5ki6A-2kzkA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		4 CYH B 428
GLN B 455
PRO B 451
ILE B 453
 None
 1.31A 5ki6A-2rgnB:
undetectable		 5ki6A-2rgnB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 ARG A  79
CYH A 163
GLN A  78
PRO A  77
 None
 1.05A 5ki6A-2y35A:
2.3		 5ki6A-2y35A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 ARG A 156
GLN A 217
PRO A 216
ILE A 219
 None
 1.18A 5ki6A-3a9gA:
undetectable		 5ki6A-3a9gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2
PROTEIN VP3

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ARG C 207
CYH C 120
GLN B 119
ILE B 228
 None
 1.43A 5ki6A-3dprC:
undetectable		 5ki6A-3dprC:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR

(Citrobacter
freundii) 		PF03466
(LysR_substrate) 		4 CYH A 169
GLN A 253
PRO A 254
ILE A 183
 None
 1.40A 5ki6A-3kosA:
undetectable		 5ki6A-3kosA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 CYH A  86
GLN A  83
PRO A  81
ILE A  55
 None
 1.33A 5ki6A-3olzA:
5.6		 5ki6A-3olzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 ARG A 207
CYH A 211
PRO A 163
ILE A 167
 None
 1.05A 5ki6A-4b9aA:
2.3		 5ki6A-4b9aA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ARG A 238
GLN A 200
PRO A 167
ILE A 196
 None
 1.35A 5ki6A-4fixA:
undetectable		 5ki6A-4fixA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.98A 5ki6A-4ig9A:
2.1		 5ki6A-4ig9A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 ARG A 686
CYH A 689
GLN A 697
PRO A 698
ILE A 700
 None
 0.27A 5ki6A-4krfA:
60.0		 5ki6A-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 CYH A 613
GLN A 607
PRO A 606
ILE A 528
 None
 1.45A 5ki6A-4n2cA:
undetectable		 5ki6A-4n2cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 ARG A 216
GLN A 237
PRO A 215
ILE A 186
 MRD  A 501 ( 4.7A)
MRD  A 501 (-3.8A)
None
CL  A 503 ( 4.7A)
 1.36A 5ki6A-4qfuA:
2.1		 5ki6A-4qfuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ARG B  11
GLN B  81
PRO B  16
ILE B 183
 None
 1.42A 5ki6A-4tx2B:
undetectable		 5ki6A-4tx2B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ARG A 514
CYH A 511
GLN A 475
ILE A 518
 ANP  A 801 (-3.2A)
None
ANP  A 801 (-4.4A)
None
 1.47A 5ki6A-4ydqA:
3.8		 5ki6A-4ydqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		4 ARG A 267
GLN A 481
PRO A 479
ILE A 451
 None
 1.48A 5ki6A-4ye9A:
undetectable		 5ki6A-4ye9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.00A 5ki6A-4zzhA:
undetectable		 5ki6A-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 ARG A 216
GLN A 213
PRO A 212
ILE A 224
 None
 1.42A 5ki6A-5dxfA:
3.8		 5ki6A-5dxfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 ARG A 269
GLN A 270
PRO A 271
ILE A 272
 None
 1.40A 5ki6A-5eqiA:
undetectable		 5ki6A-5eqiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 ARG A 218
GLN A 239
PRO A 217
ILE A 188
 PO4  A 501 ( 4.7A)
None
None
None
 1.40A 5ki6A-5msyA:
undetectable		 5ki6A-5msyA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		4 CYH A 632
GLN A 633
PRO A 329
ILE A 331
 None
 1.28A 5ki6A-5tubA:
undetectable		 5ki6A-5tubA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 ARG A 688
CYH A 691
GLN A 699
PRO A 700
ILE A 702
 None
 0.65A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 CYH A 691
GLN A 699
PRO A 700
ILE A 664
 None
 1.39A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.10A 5ki6A-5xctA:
undetectable		 5ki6A-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.08A 5ki6A-5xcuA:
undetectable		 5ki6A-5xcuA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn1 SERINE/THREONINE-PRO
TEIN KINASE HIPPO

(Drosophila
melanogaster) 		no annotation 4 ARG A 643
GLN A 644
PRO A 645
ILE A 646
 MPD  A 703 ( 3.7A)
MPD  A 703 (-4.1A)
None
None
 1.33A 5ki6A-6bn1A:
undetectable		 5ki6A-6bn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 4 ARG A 269
GLN A 207
PRO A 206
ILE A 265
 None
 1.45A 5ki6A-6eubA:
undetectable		 5ki6A-6eubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ARG A 201
GLN A 200
PRO A 196
ILE A 198
 None
 1.44A 5ki6A-6gqdA:
undetectable		 5ki6A-6gqdA:
undetectable