SIMILAR PATTERNS OF AMINO ACIDS FOR 5KI6_A_IPHA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 506
TYR A 508
LEU A 510
TYR A 438
 None
 1.20A 5ki6A-1dgsA:
undetectable		 5ki6A-1dgsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		4 LEU A2225
TYR A2183
LYS A2159
LEU A2227
 None
 1.34A 5ki6A-1g61A:
undetectable		 5ki6A-1g61A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 128
TYR A 132
LEU A 158
TYR A  97
 None
 1.41A 5ki6A-1j0nA:
0.0		 5ki6A-1j0nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jig DLP-2

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.01A 5ki6A-1jigA:
undetectable		 5ki6A-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR

(Homo sapiens) 		no annotation 4 LEU C  96
TYR C 181
LEU C  94
TYR C  77
 None
 1.35A 5ki6A-1ow0C:
undetectable		 5ki6A-1ow0C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 LEU A 101
TYR A  47
LEU A 130
TYR A 135
 None
 1.32A 5ki6A-1p9eA:
undetectable		 5ki6A-1p9eA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 LEU A 465
TYR A 397
LEU A 380
TYR A 477
 None
 1.30A 5ki6A-1px8A:
2.2		 5ki6A-1px8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LEU A 147
TYR A 157
LEU A 154
TYR A 178
 None
 1.21A 5ki6A-1uisA:
undetectable		 5ki6A-1uisA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 509
TYR A 511
LEU A 513
TYR A 441
 None
 1.18A 5ki6A-1v9pA:
undetectable		 5ki6A-1v9pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		4 LEU A  93
TYR A 130
LEU A 127
TYR A 165
 None
 1.13A 5ki6A-2fsrA:
undetectable		 5ki6A-2fsrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		4 LEU A 127
TYR A 129
LEU A 103
TYR A 109
 None
TRP  A 401 (-4.5A)
None
None
 1.28A 5ki6A-2g36A:
undetectable		 5ki6A-2g36A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 LEU A 279
TYR A 277
LEU A 414
TYR A 409
 None
 1.38A 5ki6A-2jgpA:
undetectable		 5ki6A-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd9 MID-CELL-ANCHORED
PROTEIN Z

(Streptococcus
pneumoniae) 		no annotation 4 LEU A  59
TYR A  32
LYS A  74
LEU A  62
 None
 1.29A 5ki6A-2nd9A:
undetectable		 5ki6A-2nd9A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		4 LEU A 303
TYR A 297
LYS A 282
LEU A 380
 None
 1.47A 5ki6A-2o3iA:
undetectable		 5ki6A-2o3iA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		4 LEU A  87
TYR A  88
LYS A   4
LEU A  69
 None
 1.20A 5ki6A-2paeA:
undetectable		 5ki6A-2paeA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwb CELLULASE

(Tropaeolum
majus) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		4 LEU A 128
TYR A 108
LEU A 110
TYR A 139
 None
 1.49A 5ki6A-2uwbA:
undetectable		 5ki6A-2uwbA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.11A 5ki6A-2zufA:
3.7		 5ki6A-2zufA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		4 LEU A 150
TYR A 151
LEU A 157
TYR A 181
 None
 1.40A 5ki6A-3cglA:
undetectable		 5ki6A-3cglA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 LEU A  53
TYR A  57
LEU A 221
TYR A 214
 None
 1.23A 5ki6A-3dg8A:
undetectable		 5ki6A-3dg8A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 LEU A   9
TYR A  11
LEU A  13
TYR A 256
 None
 1.22A 5ki6A-3g5aA:
undetectable		 5ki6A-3g5aA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 424
TYR A 423
LEU A 427
TYR A 441
 LEU  A 424 ( 0.6A)
TYR  A 423 ( 1.3A)
LEU  A 427 ( 0.5A)
TYR  A 441 ( 1.3A)
 1.49A 5ki6A-3gnrA:
2.1		 5ki6A-3gnrA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		4 LEU A 120
TYR A 121
LYS A  72
LEU A  79
 None
 1.43A 5ki6A-3hq0A:
undetectable		 5ki6A-3hq0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 LEU A 162
TYR A 167
LYS A 166
LEU A 133
 None
 1.27A 5ki6A-3ifsA:
3.9		 5ki6A-3ifsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		4 LEU A 175
TYR A 176
LEU A   9
TYR A 142
 None
 1.25A 5ki6A-3it7A:
undetectable		 5ki6A-3it7A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		4 LEU A 255
TYR A 259
LEU A 464
TYR A 241
 None
 1.38A 5ki6A-3iukA:
undetectable		 5ki6A-3iukA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S6,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S26,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF01250
(Ribosomal_S6)
no annotation 		4 LEU F  42
TYR d 187
LYS d 185
LEU F  65
 None
 1.24A 5ki6A-3jd5F:
undetectable		 5ki6A-3jd5F:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtn ADAPTER PROTEIN MECA
2

(Bacillus
subtilis) 		PF05389
(MecA) 		4 LEU A  65
TYR A  68
LEU A  70
TYR A  33
 None
 1.28A 5ki6A-3jtnA:
undetectable		 5ki6A-3jtnA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		4 LEU A  42
TYR A  41
LEU A  55
TYR A  52
 None
 1.19A 5ki6A-3jx9A:
undetectable		 5ki6A-3jx9A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.28A 5ki6A-3l5jA:
undetectable		 5ki6A-3l5jA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A  56
TYR A  53
LEU A 162
TYR A 161
 None
 1.34A 5ki6A-3nyoA:
undetectable		 5ki6A-3nyoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2t LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 4

(Homo sapiens) 		PF00047
(ig)
PF13895
(Ig_2) 		4 LEU A  92
TYR A 181
LEU A  90
TYR A  73
 None
 1.23A 5ki6A-3p2tA:
undetectable		 5ki6A-3p2tA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		4 LEU A 454
TYR A 453
LYS A 389
LEU A 449
 None
 1.33A 5ki6A-3pbkA:
2.5		 5ki6A-3pbkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg6 E3 UBIQUITIN-PROTEIN
LIGASE DTX3L

(Homo sapiens) 		no annotation 4 LEU A 664
LYS A 709
LEU A 727
TYR A 726
 None
 1.45A 5ki6A-3pg6A:
undetectable		 5ki6A-3pg6A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poh ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Bacteroides
thetaiotaomicron) 		PF08522
(DUF1735) 		4 LEU A 258
LYS A 464
LEU A 251
TYR A 250
 None
 1.45A 5ki6A-3pohA:
undetectable		 5ki6A-3pohA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 935
LYS A 887
LEU A 934
TYR A 923
 None
 1.46A 5ki6A-3pp0A:
undetectable		 5ki6A-3pp0A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 303
TYR A 304
LEU A 223
TYR A 222
 None
 0.83A 5ki6A-3qr1A:
undetectable		 5ki6A-3qr1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		4 LEU A 213
LYS A 211
LEU A   8
TYR A   5
 None
 1.17A 5ki6A-3qvqA:
undetectable		 5ki6A-3qvqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LEU A  64
TYR A  16
LEU A  36
TYR A  70
 None
 1.16A 5ki6A-3rx8A:
undetectable		 5ki6A-3rx8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 244
TYR A 298
LEU A 246
TYR A 287
 None
 1.48A 5ki6A-3szeA:
undetectable		 5ki6A-3szeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 LEU A 444
TYR A 443
LEU A 230
TYR A 232
 None
 1.41A 5ki6A-3tsyA:
undetectable		 5ki6A-3tsyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 713
LYS A 665
LEU A 712
TYR A 701
 None
 1.48A 5ki6A-3tt0A:
undetectable		 5ki6A-3tt0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A  53
TYR A  57
LEU A 221
TYR A 214
 None
 1.24A 5ki6A-3um6A:
1.6		 5ki6A-3um6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		4 LEU A 146
TYR A 147
LEU A 153
TYR A 177
 None
 1.27A 5ki6A-3zulA:
undetectable		 5ki6A-3zulA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		4 LEU A  37
LYS A  92
LEU A  62
TYR A  60
 None
 1.41A 5ki6A-4b96A:
undetectable		 5ki6A-4b96A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 LEU A  97
TYR A  99
LEU A  55
TYR A  52
 None
 1.30A 5ki6A-4gyoA:
undetectable		 5ki6A-4gyoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 409
TYR A 407
LYS A 343
LEU A 560
 None
 1.34A 5ki6A-4i1pA:
3.3		 5ki6A-4i1pA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 LEU A  99
TYR A 101
LEU A  55
TYR A  52
 None
 1.31A 5ki6A-4i9cA:
undetectable		 5ki6A-4i9cA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilg A1 CISTRON-SPLICING
FACTOR AAR2

(Saccharomyces
cerevisiae) 		PF05282
(AAR2) 		4 LEU A 205
TYR A 204
LEU A 210
TYR A 220
 None
 1.48A 5ki6A-4ilgA:
undetectable		 5ki6A-4ilgA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jif INTEGRIN
BETA-1-BINDING
PROTEIN 1

(Homo sapiens) 		PF10480
(ICAP-1_inte_bdg) 		4 LEU A 169
TYR A 167
LEU A  88
TYR A  91
 None
 1.39A 5ki6A-4jifA:
undetectable		 5ki6A-4jifA:
10.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 LEU A 648
TYR A 652
LEU A 692
TYR A 696
 None
 0.20A 5ki6A-4krfA:
60.0		 5ki6A-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		4 LEU A  93
TYR A  37
LEU A 122
TYR A 127
 None
 1.41A 5ki6A-4le6A:
undetectable		 5ki6A-4le6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj8 ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU A  24
TYR A  23
LYS A  22
LEU A  15
 None
 1.27A 5ki6A-4nj8A:
undetectable		 5ki6A-4nj8A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 LEU A 545
TYR A 543
LEU A 530
TYR A 566
 None
 1.41A 5ki6A-4pbxA:
undetectable		 5ki6A-4pbxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		4 LEU A 134
TYR A 131
LEU A  69
TYR A 109
 None
 1.34A 5ki6A-4qdgA:
undetectable		 5ki6A-4qdgA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 414
TYR A 413
LEU A 417
TYR A 430
 None
 1.47A 5ki6A-4qljA:
undetectable		 5ki6A-4qljA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 420
TYR A 416
LEU A 387
TYR A 433
 None
 1.49A 5ki6A-4re2A:
undetectable		 5ki6A-4re2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri1 UDP-4-AMINO-4,6-DIDE
OXY-N-ACETYL-BETA-L-
ALTROSAMINE
N-ACETYLTRANSFERASE

(Helicobacter
pylori) 		PF13420
(Acetyltransf_4) 		4 LEU A  91
TYR A  90
LEU A 123
TYR A 143
 None
 1.44A 5ki6A-4ri1A:
undetectable		 5ki6A-4ri1A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.12A 5ki6A-4wk5A:
undetectable		 5ki6A-4wk5A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU L 543
LYS L 538
LEU L 529
TYR L 476
 None
 1.30A 5ki6A-4xr7L:
undetectable		 5ki6A-4xr7L:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 LEU A  44
TYR A   2
LYS A   0
LEU A 154
 None
None
NA  A 403 (-3.8A)
None
 1.47A 5ki6A-4z5yA:
undetectable		 5ki6A-4z5yA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo4 SUPPRESSOR OF
CYTOKINE SIGNALING 2

(Homo sapiens) 		PF00017
(SH2)
PF07525
(SOCS_box) 		4 LEU A 106
LYS A 117
LEU A 125
TYR A 129
 CAS  A 111 ( 4.4A)
None
None
None
 1.43A 5ki6A-5bo4A:
undetectable		 5ki6A-5bo4A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 399
TYR A 398
LEU A 186
TYR A 188
 None
 1.22A 5ki6A-5bswA:
4.1		 5ki6A-5bswA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.90A 5ki6A-5cs0A:
undetectable		 5ki6A-5cs0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.99A 5ki6A-5csaA:
2.9		 5ki6A-5csaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.01A 5ki6A-5cslA:
2.2		 5ki6A-5cslA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		4 LEU B  97
LYS B 107
LEU B 128
TYR B 130
 None
 1.49A 5ki6A-5gj4B:
undetectable		 5ki6A-5gj4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 LEU A 181
TYR A 187
LEU A 147
TYR A 175
 None
 1.39A 5ki6A-5jt8A:
undetectable		 5ki6A-5jt8A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 LEU A 316
TYR A 324
LEU A 313
TYR A 312
 None
None
EDO  A 511 (-4.6A)
None
 1.20A 5ki6A-5kc9A:
6.8		 5ki6A-5kc9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		4 LEU A 274
LYS A 259
LEU A 297
TYR A 321
 None
 1.34A 5ki6A-5ldtA:
undetectable		 5ki6A-5ldtA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		4 LEU A 151
TYR A 152
LEU A 158
TYR A 182
 None
 1.18A 5ki6A-5lk4A:
undetectable		 5ki6A-5lk4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1951
LYS A2090
LEU A1947
TYR A1933
 None
 1.47A 5ki6A-5m5pA:
undetectable		 5ki6A-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU Q  31
TYR Q  27
LEU Q  61
TYR Q  65
 None
 1.19A 5ki6A-5mpdQ:
undetectable		 5ki6A-5mpdQ:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.56A 5ki6A-5v0iA:
undetectable		 5ki6A-5v0iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 LEU A1541
LYS A1711
LEU A1823
TYR A1824
 None
 1.41A 5ki6A-5v6tA:
undetectable		 5ki6A-5v6tA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 LEU A 651
TYR A 655
LYS A 661
LEU A 695
TYR A 699
 None
 0.82A 5ki6A-5vm9A:
56.3		 5ki6A-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 LEU A  87
TYR A  85
LEU A  83
TYR A  41
 None
 1.34A 5ki6A-5vyoA:
undetectable		 5ki6A-5vyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 ( 4.9A)
 0.88A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 4 LEU A 109
TYR A  46
LEU A 171
TYR A 168
 None
 1.45A 5ki6A-5xyhA:
undetectable		 5ki6A-5xyhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.73A 5ki6A-6dfuA:
undetectable		 5ki6A-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 LEU A1084
TYR A1107
LEU A1738
TYR A1732
 None
 1.50A 5ki6A-6fb3A:
undetectable		 5ki6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 LEU A 197
TYR A 203
LEU A 156
TYR A 160
 None
 1.34A 5ki6A-6gnfA:
2.2		 5ki6A-6gnfA:
undetectable