SIMILAR PATTERNS OF AMINO ACIDS FOR 5KGP_B_GCSB405
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0c | XYLOSE ISOMERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF01261(AP_endonuc_2) | 4 | TRP A 187GLU A 231ASP A 308TRP A 48 | None CO A 491 ( 2.4A) CO A 492 ( 2.4A)None | 0.83A | 5kgpB-1a0cA:0.3 | 5kgpB-1a0cA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0d | XYLOSE ISOMERASE (Geobacillusstearothermophilus) |
PF01261(AP_endonuc_2) | 4 | TRP A 185GLU A 229ASP A 306TRP A 47 | None MN A 491 ( 2.4A) MN A 492 ( 2.8A)None | 1.03A | 5kgpB-1a0dA:0.1 | 5kgpB-1a0dA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0e | XYLOSE ISOMERASE (Thermotoganeapolitana) |
PF01261(AP_endonuc_2) | 4 | TRP A 187GLU A 231ASP A 308TRP A 48 | None CO A 491 ( 2.4A) CO A 492 (-3.3A)None | 0.99A | 5kgpB-1a0eA:0.2 | 5kgpB-1a0eA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf5 | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION1-ALPHA/BETA (Homo sapiens) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 4 | ARG A 378GLU A 429GLY A 422PRO A 423 | None | 1.09A | 5kgpB-1bf5A:0.0 | 5kgpB-1bf5A:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1de6 | L-RHAMNOSE ISOMERASE (Escherichiacoli) |
PF06134(RhaA) | 4 | TRP A 193GLU A 234ASP A 304TRP A 48 | RNS A1462 (-3.2A) ZN A 450 ( 2.4A) MN A 451 (-2.8A)RNS A1462 ( 4.1A) | 0.78A | 5kgpB-1de6A:0.0 | 5kgpB-1de6A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gcp | VAV PROTO-ONCOGENE (Mus musculus) |
PF00018(SH3_1) | 4 | TRP A 636GLY A 611PRO A 610TRP A 649 | None | 0.91A | 5kgpB-1gcpA:undetectable | 5kgpB-1gcpA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htt | HISTIDYL-TRNASYNTHETASE (Escherichiacoli) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 4 | ARG A 104GLU A 102GLY A 137ASP A 139 | None | 1.13A | 5kgpB-1httA:0.2 | 5kgpB-1httA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1z | VAV (Mus musculus) |
PF00018(SH3_1) | 4 | TRP A 54GLY A 29PRO A 28TRP A 67 | None | 1.10A | 5kgpB-1k1zA:undetectable | 5kgpB-1k1zA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnz | SPO0B-ASSOCIATEDGTP-BINDING PROTEIN (Bacillussubtilis) |
PF01018(GTP1_OBG)PF01926(MMR_HSR1) | 4 | GLU A 148PRO A 145GLY A 13ASP A 14 | None | 1.09A | 5kgpB-1lnzA:0.0 | 5kgpB-1lnzA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 4 | ARG A 97GLY A 199PRO A 198ASP A 200 | None | 1.11A | 5kgpB-1mhsA:undetectable | 5kgpB-1mhsA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 4 | ARG A 259GLU A 48PRO A 29GLY A 283 | NoneNoneNoneMA4 A 300 ( 3.9A) | 1.11A | 5kgpB-1n9bA:undetectable | 5kgpB-1n9bA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nar | NARBONIN (Vicianarbonensis) |
PF00704(Glyco_hydro_18) | 4 | GLU A 213PRO A 223GLY A 257PRO A 256 | None | 1.11A | 5kgpB-1narA:undetectable | 5kgpB-1narA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p22 | F-BOX/WD-REPEATPROTEIN 1A (Homo sapiens) |
PF00400(WD40)PF12937(F-box-like) | 4 | ARG A 251TRP A 250GLU A 247ASP A 479 | None | 1.02A | 5kgpB-1p22A:undetectable | 5kgpB-1p22A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnr | ENDO-1,4-B-D-MANNANASE (Trichodermareesei) |
PF00150(Cellulase) | 4 | ARG A 171GLU A 205PRO A 217GLY A 208 | MAB A 401 (-2.7A)MAB A 401 (-3.9A)NoneNone | 1.11A | 5kgpB-1qnrA:1.1 | 5kgpB-1qnrA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw9 | CHONDROITIN AC LYASE (Paenarthrobacteraurescens) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | TRP A 474GLU A 473GLY A 683PRO A 684 | None | 1.02A | 5kgpB-1rw9A:undetectable | 5kgpB-1rw9A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wac | P2 PROTEIN (Pseudomonasvirus phi6) |
PF00680(RdRP_1) | 4 | ARG A 542GLY A 548PRO A 547ASP A 594 | None | 1.02A | 5kgpB-1wacA:undetectable | 5kgpB-1wacA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xbt | THYMIDINE KINASE,CYTOSOLIC (Homo sapiens) |
PF00265(TK) | 4 | ARG A 130GLY A 26PRO A 27ASP A 125 | None | 1.04A | 5kgpB-1xbtA:undetectable | 5kgpB-1xbtA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy2 | TRANSCRIPTIONALREGULATOR NTRC1 (Aquifexaeolicus) |
PF00072(Response_reg) | 4 | GLU A 31PRO A 55GLY A 33ASP A 56 | None | 0.92A | 5kgpB-1zy2A:undetectable | 5kgpB-1zy2A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0n | A197 (Sulfolobusturretedicosahedralvirus 1) |
no annotation | 4 | GLU A 150PRO A 8GLY A 119ASP A 61 | None | 1.02A | 5kgpB-2c0nA:undetectable | 5kgpB-2c0nA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7z | ACETYLENE HYDRATASEAHY (Pelobacteracetylenicus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | TRP A 83GLU A 490PRO A 487GLY A 459 | NoneNoneNoneMGD A 801 ( 3.9A) | 1.00A | 5kgpB-2e7zA:undetectable | 5kgpB-2e7zA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpg | SUCCINYL-COA LIGASE[GDP-FORMING]ALPHA-CHAIN,MITOCHONDRIAL (Sus scrofa) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 4 | ARG A 256PRO A 190GLY A 188ASP A 189 | None | 1.13A | 5kgpB-2fpgA:undetectable | 5kgpB-2fpgA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 4 | TRP A 80GLY A 233PRO A 232ASP A 153 | None | 1.10A | 5kgpB-2hg4A:undetectable | 5kgpB-2hg4A:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j87 | THYMIDINE KINASE (Vaccinia virus) |
PF00265(TK) | 4 | ARG A 115GLY A 11PRO A 12ASP A 110 | None | 1.00A | 5kgpB-2j87A:undetectable | 5kgpB-2j87A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kpt | PUTATIVE SECRETEDPROTEIN (Corynebacteriumglutamicum) |
PF04536(TPM_phosphatase) | 4 | GLU A 125PRO A 100GLY A 97ASP A 99 | None | 1.05A | 5kgpB-2kptA:undetectable | 5kgpB-2kptA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5r | GLUTAMYL-TRNASYNTHETASE 1 (Thermotogamaritima) |
PF00749(tRNA-synt_1c) | 4 | ARG A 81GLU A 84GLY A 78PRO A 79 | None | 1.12A | 5kgpB-2o5rA:undetectable | 5kgpB-2o5rA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2orv | THYMIDINE KINASE (Homo sapiens) |
PF00265(TK) | 4 | ARG A 130GLY A 26PRO A 27ASP A 125 | None | 1.03A | 5kgpB-2orvA:undetectable | 5kgpB-2orvA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozg | GCN5-RELATEDN-ACETYLTRANSFERASE (Trichormusvariabilis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 4 | ARG A 50GLU A 106PRO A 66GLY A 80 | None | 1.11A | 5kgpB-2ozgA:14.4 | 5kgpB-2ozgA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 4 | GLU A 545PRO A 536GLY A 540ASP A 537 | None | 1.00A | 5kgpB-2q1fA:undetectable | 5kgpB-2q1fA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qa1 | POLYKETIDE OXYGENASEPGAE (Streptomycessp. PGA64) |
PF01494(FAD_binding_3) | 4 | ARG A 266GLU A 312GLY A 129ASP A 125 | None | 1.09A | 5kgpB-2qa1A:undetectable | 5kgpB-2qa1A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | GLU A 267PRO A 67ASP A 69TRP A 906 | None | 0.99A | 5kgpB-2qo3A:undetectable | 5kgpB-2qo3A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vl7 | XPD (Sulfurisphaeratokodaii) |
PF06733(DEAD_2)PF13307(Helicase_C_2) | 4 | TRP A 11GLU A 345PRO A 509GLY A 36 | NoneNoneNonePO4 A1541 (-4.0A) | 1.12A | 5kgpB-2vl7A:undetectable | 5kgpB-2vl7A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xu0 | ERYTHROCYTE MEMBRANEPROTEIN 1 (Plasmodiumfalciparum) |
PF05424(Duffy_binding)PF15447(NTS) | 4 | GLU A 322PRO A 177GLY A 187ASP A 178 | None | 0.91A | 5kgpB-2xu0A:undetectable | 5kgpB-2xu0A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yhg | CELLULOSE-BINDINGPROTEIN (Saccharophagusdegradans) |
PF07632(DUF1593) | 4 | GLU A 552GLY A 751PRO A 750TRP A 763 | BTB A1945 ( 3.8A)NoneBTB A1945 ( 4.7A)BTB A1945 (-4.9A) | 1.10A | 5kgpB-2yhgA:undetectable | 5kgpB-2yhgA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yk0 | ERYTHROCYTE MEMBRANEPROTEIN 1 (Plasmodiumfalciparum) |
PF03011(PFEMP)PF05424(Duffy_binding)PF15447(NTS) | 4 | GLU A 322PRO A 177GLY A 187ASP A 178 | None | 0.93A | 5kgpB-2yk0A:undetectable | 5kgpB-2yk0A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ymv | ACG NITROREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ARG A 86GLU A 254GLY A 148PRO A 149 | FMT A1333 (-2.9A)NoneNoneNone | 0.93A | 5kgpB-2ymvA:undetectable | 5kgpB-2ymvA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzw | ABC TRANSPORTER,SOLUTE-BINDINGPROTEIN (Thermusthermophilus) |
PF03480(DctP) | 4 | TRP A 295GLY A 219PRO A 220ASP A 156 | None | 0.73A | 5kgpB-2zzwA:undetectable | 5kgpB-2zzwA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abb | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 4 | ARG A 124GLU A 160GLY A 213ASP A 212 | None | 1.07A | 5kgpB-3abbA:undetectable | 5kgpB-3abbA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 4 | GLU A 347PRO A 350GLY A 352ASP A 351 | None | 1.13A | 5kgpB-3agrA:undetectable | 5kgpB-3agrA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dgz | THIOREDOXINREDUCTASE 2 (Mus musculus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ARG A 158GLY A 13ASP A 36TRP A 47 | NoneFAD A 500 (-3.1A)FAD A 500 (-2.8A)None | 1.08A | 5kgpB-3dgzA:undetectable | 5kgpB-3dgzA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoo | METHYLISOCITRATELYASE (Burkholderiapseudomallei) |
PF13714(PEP_mutase) | 4 | ARG A 160GLU A 117GLY A 63ASP A 61 | None | 1.14A | 5kgpB-3eooA:undetectable | 5kgpB-3eooA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqq | BENZENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonasputida) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | GLU A 45PRO A 332GLY A 334PRO A 335 | None | 1.01A | 5kgpB-3eqqA:undetectable | 5kgpB-3eqqA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff0 | PHENAZINEBIOSYNTHESIS PROTEINPHZB 2 (Pseudomonasaeruginosa) |
PF03284(PHZA_PHZB) | 4 | GLU A 114PRO A 79GLY A 105ASP A 80 | None | 0.67A | 5kgpB-3ff0A:undetectable | 5kgpB-3ff0A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fqd | 5'-3'EXORIBONUCLEASE 2PROTEIN DIN1 (Schizosaccharomycespombe) |
PF03159(XRN_N)PF08652(RAI1) | 4 | ARG A 218GLU A 247GLY A 854TRP B 159 | None | 1.02A | 5kgpB-3fqdA:undetectable | 5kgpB-3fqdA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpg | INTEGRASE (Visna-maedivirus) |
PF00665(rve)PF02022(Integrase_Zn) | 4 | GLU A 94GLY A 120PRO A 121ASP A 118 | None | 1.07A | 5kgpB-3hpgA:undetectable | 5kgpB-3hpgA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jup | PHENAZINEBIOSYNTHESIS PROTEINA/B (Burkholderialata) |
PF03284(PHZA_PHZB) | 4 | ARG A 117PRO A 82GLY A 108ASP A 83 | None | 0.62A | 5kgpB-3jupA:undetectable | 5kgpB-3jupA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 4 | TRP A 126GLU A 166ASP A 240TRP A 14 | UNL A 337 ( 3.7A) FE A 334 (-2.6A) FE A 333 (-2.5A)UNL A 337 ( 3.9A) | 1.03A | 5kgpB-3ktcA:undetectable | 5kgpB-3ktcA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ARG A 240TRP A 10GLU A 244GLY A 11 | None | 0.94A | 5kgpB-3m07A:0.7 | 5kgpB-3m07A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moi | PROBABLEDEHYDROGENASE (Bordetellabronchiseptica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ARG A 295PRO A 128GLY A 335ASP A 343 | None | 1.00A | 5kgpB-3moiA:undetectable | 5kgpB-3moiA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg5 | UNCHARACTERIZEDPROTEIN (Corynebacteriumdiphtheriae) |
PF13614(AAA_31) | 4 | PRO A 40GLY A 162PRO A 163ASP A 39 | None | 1.09A | 5kgpB-3pg5A:undetectable | 5kgpB-3pg5A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptk | BETA-GLUCOSIDASEOS4BGLU12 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | GLU A 417PRO A 370GLY A 358PRO A 359 | None | 1.02A | 5kgpB-3ptkA:0.8 | 5kgpB-3ptkA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4d | LACTOSEPHOSPHORYLASE (Cellulomonasuda) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | ARG A 188GLU A 174ASP A 280TRP A 278 | None | 0.97A | 5kgpB-3s4dA:undetectable | 5kgpB-3s4dA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsc | PROTEIN CYSO (Aeropyrumpernix) |
PF00291(PALP) | 4 | PRO A 368GLY A 339PRO A 340ASP A 369 | PLP A 401 (-4.1A)NoneNonePLP A 401 (-3.5A) | 1.02A | 5kgpB-3vscA:undetectable | 5kgpB-3vscA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfl | BETA-MANNANASE (Talaromycestrachyspermus) |
PF00150(Cellulase) | 4 | ARG A 203GLU A 237PRO A 250GLY A 240 | None | 1.13A | 5kgpB-3wflA:undetectable | 5kgpB-3wflA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh9 | ENDO-BETA-1,4-MANNANASE (Aspergillusniger) |
PF00150(Cellulase) | 4 | ARG A 170GLU A 204PRO A 217GLY A 207 | None | 1.09A | 5kgpB-3wh9A:0.7 | 5kgpB-3wh9A:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zeu | PROBABLE TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN GCP (Salmonellaenterica) |
PF00814(Peptidase_M22) | 4 | PRO B 178GLY B 180PRO B 181ASP B 167 | NoneAGS B1342 (-3.4A)AGS B1342 (-3.8A)ADP B1343 (-2.9A) | 0.96A | 5kgpB-3zeuB:undetectable | 5kgpB-3zeuB:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zz1 | BETA-D-GLUCOSIDEGLUCOHYDROLASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ARG A 169GLU A 166GLY A 115PRO A 116 | None | 0.99A | 5kgpB-3zz1A:undetectable | 5kgpB-3zz1A:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bil | DNA MATURASE B (Escherichiavirus T7) |
no annotation | 4 | GLU A 232PRO A 263GLY A 61ASP A 262 | None | 1.10A | 5kgpB-4bilA:undetectable | 5kgpB-4bilA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 4 | GLU A 318PRO A 367GLY A 309ASP A 94 | NoneNoneNoneHEM A1741 ( 4.9A) | 1.00A | 5kgpB-4c51A:undetectable | 5kgpB-4c51A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cd8 | ENDO-BETA-1,4-MANNANASE (Alicyclobacillusacidocaldarius) |
no annotation | 4 | GLU A 106PRO A 58GLY A 101ASP A 100 | None | 1.08A | 5kgpB-4cd8A:undetectable | 5kgpB-4cd8A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cxf | RNA POLYMERASE SIGMAFACTOR CNRH (Cupriavidusmetallidurans) |
PF04542(Sigma70_r2)PF08281(Sigma70_r4_2) | 4 | ARG A 72GLU A 158PRO A 70ASP A 5 | None | 1.02A | 5kgpB-4cxfA:undetectable | 5kgpB-4cxfA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dfs | GLYCOSIDE HYDROLASE,FAMILY 16 (Thermotogapetrophila) |
PF00722(Glyco_hydro_16) | 4 | TRP A 112PRO A 236GLY A 234PRO A 233 | None | 1.04A | 5kgpB-4dfsA:undetectable | 5kgpB-4dfsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkw | LARGE TERMINASEPROTEIN (Salmonellavirus P22) |
PF17289(Terminase_6C) | 4 | GLU A 419PRO A 407GLY A 410ASP A 408 | None | 0.96A | 5kgpB-4dkwA:undetectable | 5kgpB-4dkwA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gji | L-RHAMNOSE ISOMERASE (Pseudomonasstutzeri) |
no annotation | 4 | TRP A 179GLU A 219ASP A 291TRP A 57 | RNS A1001 (-3.3A) MN A1003 ( 2.6A) MN A1004 ( 3.9A)RNS A1001 (-3.5A) | 1.04A | 5kgpB-4gjiA:undetectable | 5kgpB-4gjiA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gn8 | REGUCALCIN (Mus musculus) |
PF08450(SGL) | 4 | ARG A 264PRO A 35GLY A 17ASP A 33 | None | 1.12A | 5kgpB-4gn8A:undetectable | 5kgpB-4gn8A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | ARG A 35GLU A 514GLY A 155PRO A 156 | None | 1.02A | 5kgpB-4ha6A:undetectable | 5kgpB-4ha6A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ARG A 200GLU A 197GLY A 146PRO A 147 | BGC A 942 (-3.8A)NoneNoneNone | 1.02A | 5kgpB-4iigA:undetectable | 5kgpB-4iigA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ir8 | SEDOHEPTULOSE-1,7BISPHOSPHATASE,PUTATIVE (Toxoplasmagondii) |
PF00316(FBPase) | 4 | TRP A 119PRO A 244GLY A 240ASP A 245 | None | 1.13A | 5kgpB-4ir8A:undetectable | 5kgpB-4ir8A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jed | GLUTATHIONES-TRANSFERASE (Methylobacteriumradiotolerans) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ARG A 156PRO A 87GLY A 91ASP A 88 | None | 1.05A | 5kgpB-4jedA:undetectable | 5kgpB-4jedA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 4 | TRP A 265PRO A 255GLY A 300PRO A 301 | None | 1.10A | 5kgpB-4kg7A:undetectable | 5kgpB-4kg7A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n01 | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 4 | TRP A 150GLU A 45PRO A 129GLY A 127 | None | 0.99A | 5kgpB-4n01A:undetectable | 5kgpB-4n01A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nek | ENOYL-COAHYDRATASE/CARNITHINERACEMASE (Magnetospirillummagneticum) |
PF00378(ECH_1) | 4 | ARG A 151GLU A 154GLY A 163ASP A 165 | None | 1.09A | 5kgpB-4nekA:undetectable | 5kgpB-4nekA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 4 | ARG A1023GLU A 998PRO A1086GLY A1084 | None | 0.76A | 5kgpB-4ogcA:undetectable | 5kgpB-4ogcA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo3 | HYPOTHETICAL PROTEIN (Parabacteroidesmerdae) |
PF01408(GFO_IDH_MocA)PF16490(Oxidoreduct_C) | 4 | ARG A 226GLY A 237ASP A 242TRP A 329 | None | 0.90A | 5kgpB-4oo3A:undetectable | 5kgpB-4oo3A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ow8 | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacteriumtuberculosis) |
PF00069(Pkinase) | 4 | ARG A 215GLU A 209GLY A 145PRO A 144 | None | 0.97A | 5kgpB-4ow8A:undetectable | 5kgpB-4ow8A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p56 | PUTATIVEEXTRACELLULARSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 4 | GLU A 228GLY A 147PRO A 148ASP A 278 | None | 1.11A | 5kgpB-4p56A:undetectable | 5kgpB-4p56A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 4 | ARG A 356GLU A 518PRO A 362GLY A 360 | GOL A2007 (-3.7A)GOL A2007 ( 3.4A)NoneNone | 1.12A | 5kgpB-4q73A:undetectable | 5kgpB-4q73A:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r29 | UNCHARACTERIZEDPROTEIN (Escherichiacoli) |
no annotation | 4 | GLU A 200GLY A 207PRO A 206ASP A 210 | None | 1.09A | 5kgpB-4r29A:undetectable | 5kgpB-4r29A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ru1 | MONOSACCHARIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, CUT2 FAMILY (Acidothermuscellulolyticus) |
PF13407(Peripla_BP_4) | 4 | ARG A 190GLU A 156GLY A 312PRO A 313 | INS A 401 (-2.6A)NoneNoneNone | 1.03A | 5kgpB-4ru1A:undetectable | 5kgpB-4ru1A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x3f | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacteriumtuberculosis) |
PF00069(Pkinase) | 4 | ARG A 215GLU A 209GLY A 145PRO A 144 | None | 1.04A | 5kgpB-4x3fA:undetectable | 5kgpB-4x3fA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkm | XYLOSE ISOMERASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | TRP A 190GLU A 234ASP A 311TRP A 51 | None MN A 501 (-2.5A) MN A 502 (-2.9A)None | 0.95A | 5kgpB-4xkmA:0.6 | 5kgpB-4xkmA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | GLU A 231GLY A 630PRO A 629ASP A 673 | None | 1.06A | 5kgpB-4yswA:undetectable | 5kgpB-4yswA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zb6 | PCURE2P4 (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 4 | TRP A 176PRO A 60GLY A 16PRO A 17 | GDS A 300 (-4.0A)GDS A 300 (-4.5A)GDS A 300 (-3.7A) NA A 301 ( 4.6A) | 1.06A | 5kgpB-4zb6A:undetectable | 5kgpB-4zb6A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zb8 | PCURE2P6 (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 4 | TRP A 175PRO A 59GLY A 15PRO A 16 | GDS A 300 (-4.0A)GDS A 300 (-4.4A)GDS A 300 (-3.6A)GDS A 300 (-4.2A) | 1.12A | 5kgpB-4zb8A:undetectable | 5kgpB-4zb8A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ze8 | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN(AGROCINOPINES A ANDB) (Agrobacteriumfabrum) |
PF00496(SBP_bac_5) | 4 | GLU A 513GLY A 204PRO A 205ASP A 65 | PEG A 605 ( 4.1A)NoneNoneNone | 0.92A | 5kgpB-4ze8A:undetectable | 5kgpB-4ze8A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ARG A 201GLU A 198GLY A 147PRO A 148 | None | 1.01A | 5kgpB-5fjjA:undetectable | 5kgpB-5fjjA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hmq | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Pseudomonasputida) |
PF00903(Glyoxalase)PF01261(AP_endonuc_2)PF14696(Glyoxalase_5) | 4 | ARG A 310GLU A 593GLY A 359PRO A 360 | None | 1.03A | 5kgpB-5hmqA:undetectable | 5kgpB-5hmqA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuy | MULTIDRUG EFFLUXOUTER MEMBRANEPROTEIN OPRN (Pseudomonasaeruginosa) |
PF02321(OEP) | 4 | ARG A 372GLU A 427GLY A 158ASP A 155 | None | 1.12A | 5kgpB-5iuyA:undetectable | 5kgpB-5iuyA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kf2 | PREDICTEDACETYLTRANSFERASE (Clostridiumacetobutylicum) |
PF00583(Acetyltransf_1) | 8 | ARG A 192TRP A 193GLU A 196PRO A 235GLY A 251PRO A 252ASP A 287TRP A 288 | NonePO4 A 405 (-3.7A)NoneNoneNoneNoneNoneNone | 0.30A | 5kgpB-5kf2A:50.7 | 5kgpB-5kf2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kf2 | PREDICTEDACETYLTRANSFERASE (Clostridiumacetobutylicum) |
PF00583(Acetyltransf_1) | 5 | TRP A 193PRO A 236PRO A 252ASP A 287TRP A 288 | PO4 A 405 (-3.7A)NoneNoneNoneNone | 1.49A | 5kgpB-5kf2A:50.7 | 5kgpB-5kf2A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 4 | ARG A 344GLU A 313GLY A 310PRO A 311 | None | 0.86A | 5kgpB-5l46A:undetectable | 5kgpB-5l46A:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mps | PRE-MRNA-PROCESSINGFACTOR 17 (Saccharomycescerevisiae) |
PF00249(Myb_DNA-binding) | 4 | ARG o 200PRO o 162GLY o 182ASP o 184 | None | 1.05A | 5kgpB-5mpso:undetectable | 5kgpB-5mpso:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 4 | GLU A 465GLY A 475ASP A 474TRP A 314 | None | 1.10A | 5kgpB-5n4lA:undetectable | 5kgpB-5n4lA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nhb | XYLOSE ISOMERASE (Piromyces sp.E2) |
no annotation | 4 | TRP A 189GLU A 233ASP A 310TRP A 50 | NoneFE2 A 501 (-2.2A)FE2 A 502 ( 3.9A)None | 0.99A | 5kgpB-5nhbA:undetectable | 5kgpB-5nhbA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 4 | ARG A 215TRP A 218GLU A 217PRO A 155 | None | 1.14A | 5kgpB-5o0jA:undetectable | 5kgpB-5o0jA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ui2 | ORANGECAROTENOID-BINDINGPROTEIN (Arthrospiramaxima) |
PF02136(NTF2)PF09150(Carot_N) | 4 | ARG A 115GLU A 112GLY A 57PRO A 56 | NoneNoneSUC A 401 (-4.2A)SUC A 401 (-3.8A) | 0.94A | 5kgpB-5ui2A:undetectable | 5kgpB-5ui2A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 4 | ARG A 260GLY A 116ASP A 139TRP A 150 | NoneFAD A 601 (-3.1A)FAD A 601 (-3.0A)None | 1.12A | 5kgpB-5w1jA:undetectable | 5kgpB-5w1jA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1n | VANILLATE/3-O-METHYLGALLATEO-DEMETHYLASE (Sphingobium sp.SYK-6) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | TRP A 41GLU A 37PRO A 368ASP A 366 | None | 1.11A | 5kgpB-5x1nA:undetectable | 5kgpB-5x1nA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4j | XYLOSE ISOMERASE (Streptomycesrubiginosus) |
PF01261(AP_endonuc_2) | 4 | TRP A 137GLU A 181ASP A 257TRP A 16 | XYL A 402 (-3.8A)XYL A 402 ( 2.4A)NoneXYL A 402 (-4.1A) | 1.09A | 5kgpB-5y4jA:undetectable | 5kgpB-5y4jA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2q | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacteriumtuberculosis) |
no annotation | 4 | ARG A 215GLU A 209GLY A 145PRO A 144 | None | 0.94A | 5kgpB-6b2qA:undetectable | 5kgpB-6b2qA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq6 | THERMOSPERMINESYNTHASE (Medicagotruncatula) |
no annotation | 4 | GLU A 33GLY A 216PRO A 217ASP A 181 | None | 1.11A | 5kgpB-6bq6A:1.5 | 5kgpB-6bq6A:14.65 |