SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC4_E_RBFE201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 LYS A 173
ASP A 171
ILE A 206
 None
 0.86A 5kc4E-1fp2A:
0.3		 5kc4E-1fp2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LYS A 883
ASP A 885
ILE A 792
 None
 0.86A 5kc4E-1i8qA:
0.6		 5kc4E-1i8qA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		3 LYS A 126
ASP A 124
ILE A 171
 None
 0.90A 5kc4E-1j08A:
undetectable		 5kc4E-1j08A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 3 LYS A 188
ASP A 186
ILE A 181
 None
 0.84A 5kc4E-1oy1A:
undetectable		 5kc4E-1oy1A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 LYS A 360
ASP A 356
ILE A 278
 None
 0.68A 5kc4E-1qlbA:
2.1		 5kc4E-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 LYS A 338
ASP A 336
ILE A 346
 None
 0.72A 5kc4E-1sqgA:
3.0		 5kc4E-1sqgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		3 LYS A  22
ASP A 392
ILE A 315
 None
 0.89A 5kc4E-1ur4A:
0.0		 5kc4E-1ur4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		3 LYS A 101
ASP A  97
ILE A  55
 None
 0.86A 5kc4E-1vpeA:
undetectable		 5kc4E-1vpeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LYS A 155
ASP A 152
ILE A 161
 LYS  A 155 ( 0.0A)
ASP  A 152 ( 0.6A)
ILE  A 161 ( 0.7A)
 0.87A 5kc4E-1wqaA:
0.0		 5kc4E-1wqaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 LYS A  75
ASP A  80
ILE A 182
 None
GOL  A1004 (-2.9A)
GOL  A1005 (-4.2A)
 0.68A 5kc4E-1x1nA:
undetectable		 5kc4E-1x1nA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		3 LYS A 253
ASP A 247
ILE A 235
 None
 0.75A 5kc4E-1xovA:
undetectable		 5kc4E-1xovA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		3 LYS A 222
ASP A 218
ILE A 227
 None
 0.83A 5kc4E-1yp4A:
undetectable		 5kc4E-1yp4A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzk HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN K

(Homo sapiens) 		PF00013
(KH_1) 		3 LYS A  48
ASP A  50
ILE A  39
 None
 0.89A 5kc4E-1zzkA:
undetectable		 5kc4E-1zzkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag5 DEHYDROGENASE/REDUCT
ASE (SDR FAMILY)
MEMBER 6

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 LYS A   7
ASP A   5
ILE A  34
 None
 0.80A 5kc4E-2ag5A:
undetectable		 5kc4E-2ag5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		3 LYS A 164
ASP A 161
ILE A 141
 None
 0.70A 5kc4E-2ahwA:
undetectable		 5kc4E-2ahwA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		3 LYS A 212
ASP A 143
ILE A 184
 None
ADP  A 852 ( 4.6A)
None
 0.84A 5kc4E-2akoA:
undetectable		 5kc4E-2akoA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 LYS A 608
ASP A 283
ILE A 623
 None
 0.81A 5kc4E-2gj4A:
undetectable		 5kc4E-2gj4A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 LYS A 148
ASP A 144
ILE A 154
 None
 0.88A 5kc4E-2hekA:
undetectable		 5kc4E-2hekA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 LYS A 161
ASP A 137
ILE A 188
 None
 0.86A 5kc4E-2id5A:
undetectable		 5kc4E-2id5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iye COPPER-TRANSPORTING
ATPASE

(Sulfolobus
solfataricus) 		PF00702
(Hydrolase) 		3 LYS A 417
ASP A 588
ILE A 538
 None
 0.84A 5kc4E-2iyeA:
undetectable		 5kc4E-2iyeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		3 LYS A 147
ASP A 152
ILE A 193
 None
 0.87A 5kc4E-2nypA:
undetectable		 5kc4E-2nypA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqk PUTATIVE TRANSLATION
INITIATION FACTOR
EIF-1A

(Cryptosporidium
parvum) 		PF01176
(eIF-1a) 		3 LYS A  88
ASP A  86
ILE A  91
 None
 0.68A 5kc4E-2oqkA:
undetectable		 5kc4E-2oqkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 LYS A  34
ASP A  78
ILE A 126
 None
 0.89A 5kc4E-2ptsA:
2.9		 5kc4E-2ptsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		3 LYS A 455
ASP A 457
ILE A 463
 None
 0.84A 5kc4E-2w20A:
undetectable		 5kc4E-2w20A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A 155
ASP A 168
ILE A 151
 None
 0.57A 5kc4E-2x4dA:
undetectable		 5kc4E-2x4dA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		3 LYS A 821
ASP A 771
ILE A 802
 None
 0.81A 5kc4E-2x8aA:
undetectable		 5kc4E-2x8aA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 LYS A 480
ASP A 482
ILE A 577
 None
 0.90A 5kc4E-2xtlA:
3.0		 5kc4E-2xtlA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvq CARBAMOYL-PHOSPHATE
SYNTHASE

(Homo sapiens) 		PF02142
(MGS) 		3 LYS A1425
ASP A1429
ILE A1452
 None
 0.79A 5kc4E-2yvqA:
undetectable		 5kc4E-2yvqA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 LYS A 608
ASP A 283
ILE A 623
 None
NBG  A   1 ( 4.5A)
None
 0.75A 5kc4E-3cemA:
undetectable		 5kc4E-3cemA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		3 LYS A 187
ASP A 137
ILE A 258
 None
 0.59A 5kc4E-3ct4A:
undetectable		 5kc4E-3ct4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		3 LYS A  68
ASP A  88
ILE A  65
 None
 0.85A 5kc4E-3fscA:
undetectable		 5kc4E-3fscA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		3 LYS A 163
ASP A 179
ILE A 208
 None
 0.88A 5kc4E-3g4eA:
undetectable		 5kc4E-3g4eA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 LYS A 438
ASP A 436
ILE A 461
 None
 0.76A 5kc4E-3h09A:
undetectable		 5kc4E-3h09A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LYS A  56
ASP A  58
ILE A  53
 None
 0.77A 5kc4E-3k92A:
1.4		 5kc4E-3k92A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 LYS A  41
ASP A  37
ILE A 126
 None
 0.73A 5kc4E-3k9dA:
undetectable		 5kc4E-3k9dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgd PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		3 LYS A  36
ASP A  33
ILE A  12
 None
 0.85A 5kc4E-3mgdA:
undetectable		 5kc4E-3mgdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LYS A 244
ASP A 253
ILE A  47
 TPP  A 700 (-2.7A)
None
None
 0.82A 5kc4E-3mosA:
undetectable		 5kc4E-3mosA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		3 LYS A 323
ASP A 209
ILE A 305
 None
 0.79A 5kc4E-3n91A:
undetectable		 5kc4E-3n91A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		3 LYS A   1
ASP A  21
ILE A 116
 None
 0.65A 5kc4E-3nyiA:
undetectable		 5kc4E-3nyiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		3 LYS A  15
ASP A  13
ILE A  58
 None
 0.88A 5kc4E-3oz7A:
undetectable		 5kc4E-3oz7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Clostridioides
difficile) 		PF12683
(DUF3798) 		3 LYS A  38
ASP A  36
ILE A 339
 None
 0.91A 5kc4E-3qi7A:
undetectable		 5kc4E-3qi7A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjs DYNEIN LIGHT CHAIN
MOTOR PROTEIN

(Toxoplasma
gondii) 		PF01221
(Dynein_light) 		3 LYS A   5
ASP A   3
ILE A   8
 None
 0.91A 5kc4E-3rjsA:
undetectable		 5kc4E-3rjsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux9 INTERFERON
ALPHA-1/13

(Homo sapiens) 		PF00143
(Interferon) 		3 LYS A  51
ASP A  44
ILE A 117
 None
 0.69A 5kc4E-3ux9A:
undetectable		 5kc4E-3ux9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		3 LYS A 157
ASP A 153
ILE A 232
 None
 0.87A 5kc4E-3zbyA:
2.1		 5kc4E-3zbyA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh7 PROTEIN E

(Haemophilus
influenzae) 		PF16747
(Adhesin_E) 		3 LYS A  95
ASP A  69
ILE A  65
 EDO  A1154 (-2.6A)
None
None
 0.82A 5kc4E-3zh7A:
undetectable		 5kc4E-3zh7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a04 T-BOX TRANSCRIPTION
FACTOR TBX1

(Homo sapiens) 		PF00907
(T-box) 		3 LYS A 134
ASP A 224
ILE A 131
 None
 0.83A 5kc4E-4a04A:
undetectable		 5kc4E-4a04A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 LYS C 507
ASP C 505
ILE C 618
 None
 0.90A 5kc4E-4aq1C:
undetectable		 5kc4E-4aq1C:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 LYS A 212
ASP A 209
ILE A 189
 None
 0.87A 5kc4E-4az7A:
undetectable		 5kc4E-4az7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LYS A 748
ASP A 751
ILE A 781
 None
 0.84A 5kc4E-4bedA:
3.0		 5kc4E-4bedA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 LYS A  53
ASP A 400
ILE A  37
 None
 0.86A 5kc4E-4d4lA:
undetectable		 5kc4E-4d4lA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		3 LYS A 163
ASP A 179
ILE A 208
 None
 0.85A 5kc4E-4gn8A:
undetectable		 5kc4E-4gn8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		3 LYS A 242
ASP A 299
ILE A 224
 None
 0.90A 5kc4E-4hhrA:
undetectable		 5kc4E-4hhrA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho7 HSLVU COMPLEX
PROTEOLYTIC SUBUNIT,
PUTATIVE

(Trypanosoma
brucei) 		PF00227
(Proteasome) 		3 LYS A  34
ASP A 168
ILE A  54
 None
 0.84A 5kc4E-4ho7A:
undetectable		 5kc4E-4ho7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf8 TRWG COMPONENT OF
TYPE IV SECRETION
SYSTEM

(Bartonella
birtlesii) 		PF04335
(VirB8) 		3 LYS A 153
ASP A 181
ILE A 117
 None
 0.82A 5kc4E-4jf8A:
undetectable		 5kc4E-4jf8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum) 		PF00753
(Lactamase_B) 		3 LYS A 178
ASP A 170
ILE A  38
 None
 0.61A 5kc4E-4keqA:
undetectable		 5kc4E-4keqA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 3 LYS A 483
ASP A 345
ILE A 459
 None
 0.77A 5kc4E-4lc9A:
undetectable		 5kc4E-4lc9A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 LYS A 112
ASP A 110
ILE A 119
 None
 0.85A 5kc4E-4lgmA:
undetectable		 5kc4E-4lgmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nps BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		3 LYS A 279
ASP A 281
ILE A 276
 None
 0.81A 5kc4E-4npsA:
1.8		 5kc4E-4npsA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143

(Actinia equina) 		PF01353
(GFP) 		3 LYS A 136
ASP A 166
ILE A  57
 None
 0.48A 5kc4E-4ohsA:
undetectable		 5kc4E-4ohsA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		3 LYS A 184
ASP A 186
ILE A 180
 None
 0.91A 5kc4E-4q6kA:
undetectable		 5kc4E-4q6kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 LYS A1486
ASP A1488
ILE A1483
 None
 0.76A 5kc4E-4r04A:
3.2		 5kc4E-4r04A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		3 LYS B 376
ASP B 339
ILE B 398
 None
 0.79A 5kc4E-4r7aB:
undetectable		 5kc4E-4r7aB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmm PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chromobacterium
violaceum) 		PF03061
(4HBT) 		3 LYS A   5
ASP A  10
ILE A  76
 None
 0.88A 5kc4E-4rmmA:
undetectable		 5kc4E-4rmmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2

(Homo sapiens) 		PF13923
(zf-C3HC4_2) 		3 LYS B  59
ASP B 107
ILE B  53
 None
 0.79A 5kc4E-4s3oB:
undetectable		 5kc4E-4s3oB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uug AMINE TRANSAMINASE

(Aspergillus
fumigatus) 		PF01063
(Aminotran_4) 		3 LYS A  88
ASP A  83
ILE A 138
 None
 0.88A 5kc4E-4uugA:
undetectable		 5kc4E-4uugA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 LYS A 293
ASP A 289
ILE A 299
 None
 0.91A 5kc4E-4wcxA:
undetectable		 5kc4E-4wcxA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL

(Caenorhabditis
elegans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 LYS A 108
ASP A 104
ILE A 154
 None
 0.86A 5kc4E-4x9qA:
undetectable		 5kc4E-4x9qA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 LYS A 490
ASP A 488
ILE A 498
 None
 0.75A 5kc4E-4xgtA:
undetectable		 5kc4E-4xgtA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		3 LYS A 511
ASP A 508
ILE A 399
 None
 0.84A 5kc4E-4xivA:
undetectable		 5kc4E-4xivA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqy RINGHALEXIN

(Hemachatus
haemachatus) 		PF00087
(Toxin_TOLIP) 		3 LYS A  27
ASP A  56
ILE A  32
 None
 0.90A 5kc4E-4zqyA:
undetectable		 5kc4E-4zqyA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 LYS A  53
ASP A 400
ILE A  37
 None
 0.89A 5kc4E-5ajzA:
undetectable		 5kc4E-5ajzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		3 LYS A 486
ASP A 484
ILE A 620
 None
 0.91A 5kc4E-5c1bA:
undetectable		 5kc4E-5c1bA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		3 LYS A 186
ASP A 182
ILE A  98
 None
 0.91A 5kc4E-5czyA:
undetectable		 5kc4E-5czyA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 LYS A 117
ASP A 113
ILE A 434
 None
 0.82A 5kc4E-5f4lA:
undetectable		 5kc4E-5f4lA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		3 LYS A 668
ASP A 666
ILE A 675
 None
 0.87A 5kc4E-5frsA:
undetectable		 5kc4E-5frsA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4q DNA POLYMERASE III
SUBUNIT BETA

(Helicobacter
pylori) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LYS A 364
ASP A 136
ILE A 350
 None
 0.87A 5kc4E-5g4qA:
undetectable		 5kc4E-5g4qA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		3 LYS A 304
ASP A 130
ILE A 226
 None
 0.84A 5kc4E-5hn7A:
2.0		 5kc4E-5hn7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j2l PROTEIN DESIGN
2L4HC2_11

(synthetic
construct) 		no annotation 3 LYS B  46
ASP B  42
ILE B  52
 None
 0.88A 5kc4E-5j2lB:
undetectable		 5kc4E-5j2lB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		3 LYS A 203
ASP A 209
ILE A 691
 ARG  A 801 ( 4.5A)
None
None
 0.91A 5kc4E-5jxfA:
2.8		 5kc4E-5jxfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC

(Homo sapiens) 		PF00180
(Iso_dh) 		3 LYS A 374
ASP A 390
ILE A 330
 None
 0.74A 5kc4E-5k10A:
undetectable		 5kc4E-5k10A:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		3 LYS A  35
ASP A  37
ILE A 145
 RBF  A 201 (-3.3A)
None
RBF  A 201 ( 4.6A)
 0.54A 5kc4E-5kbwA:
28.4		 5kc4E-5kbwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9z HEPARANASE

(Homo sapiens) 		no annotation 3 LYS B  98
ASP B 100
ILE B  61
 None
 0.89A 5kc4E-5l9zB:
undetectable		 5kc4E-5l9zB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		3 LYS A 188
ASP A 186
ILE A 181
 None
 0.86A 5kc4E-5lirA:
undetectable		 5kc4E-5lirA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 3 LYS A  65
ASP A  67
ILE A  52
 None
 0.89A 5kc4E-5lj6A:
3.0		 5kc4E-5lj6A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 LYS A1841
ASP A1824
ILE A1763
 None
 0.63A 5kc4E-5m5pA:
1.9		 5kc4E-5m5pA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		3 LYS A 376
ASP A 374
ILE A  32
 None
 0.62A 5kc4E-5mb4A:
undetectable		 5kc4E-5mb4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei) 		PF00117
(GATase) 		3 LYS A 379
ASP A 375
ILE A 387
 None
 0.82A 5kc4E-5n29A:
undetectable		 5kc4E-5n29A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nrm DOCCEL5: TYPE I
DOCKERIN REPEAT
DOMAIN FROM A.
CELLULOLYTICUS
FAMILY 5
ENDOGLUCANASE
WP_010249057 S51I,
L52N MUTANT

(Acetivibrio
cellulolyticus) 		no annotation 3 LYS B   4
ASP B  37
ILE B  57
 None
 0.63A 5kc4E-5nrmB:
undetectable		 5kc4E-5nrmB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica) 		PF00551
(Formyl_trans_N)
PF13637
(Ank_4) 		3 LYS A 124
ASP A 126
ILE A  93
 None
 0.89A 5kc4E-5uinA:
undetectable		 5kc4E-5uinA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0h SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 3 LYS A 329
ASP A 327
ILE A 263
 None
 0.82A 5kc4E-5w0hA:
undetectable		 5kc4E-5w0hA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 3 LYS A 424
ASP A 426
ILE A 472
 None
ZN  A1008 (-2.2A)
None
 0.83A 5kc4E-5w21A:
undetectable		 5kc4E-5w21A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 LYS c 204
ASP c 210
ILE c 200
 U  N 107 ( 4.3A)
None
None
 0.89A 5kc4E-5wsgc:
undetectable		 5kc4E-5wsgc:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN S10

(Spinacia
oleracea) 		no annotation 3 LYS j 102
ASP j 190
ILE j  99
 U  a1075 ( 3.2A)
None
None
 0.91A 5kc4E-5x8rj:
undetectable		 5kc4E-5x8rj:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		3 LYS A 990
ASP A1019
ILE A 981
 None
 0.90A 5kc4E-5xvmA:
undetectable		 5kc4E-5xvmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US11

(Toxoplasma
gondii) 		PF00411
(Ribosomal_S11) 		3 LYS O 101
ASP O 136
ILE O  47
 None
 0.89A 5kc4E-5xxuO:
undetectable		 5kc4E-5xxuO:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 3 LYS A 322
ASP A 324
ILE A 365
 None
 0.72A 5kc4E-5ygfA:
undetectable		 5kc4E-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6m CYANATE HYDRATASE

(Serratia
proteamaculans) 		no annotation 3 LYS A 127
ASP A 129
ILE A 121
 None
 0.64A 5kc4E-6b6mA:
undetectable		 5kc4E-6b6mA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 3 LYS A1364
ASP A1366
ILE A1357
 None
 0.86A 5kc4E-6c0bA:
undetectable		 5kc4E-6c0bA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 3 LYS A 226
ASP A 222
ILE A 354
 None
 0.91A 5kc4E-6c4rA:
undetectable		 5kc4E-6c4rA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 3 LYS A 318
ASP A 321
ILE A 144
 None
 0.76A 5kc4E-6dchA:
undetectable		 5kc4E-6dchA:
22.22