SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC4_A_RBFA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A  39
LEU A 110
ILE A 207
 None
 0.80A 5kc4A-1amuA:
0.0		 5kc4A-1amuA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LYS A  58
LEU A 198
ILE A  61
 None
 0.82A 5kc4A-1aorA:
0.0		 5kc4A-1aorA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 LYS A  13
LEU A   5
ILE A 229
 None
 0.79A 5kc4A-1atiA:
0.0		 5kc4A-1atiA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		3 LYS A 159
LEU A 127
ILE A 134
 None
 0.79A 5kc4A-1b0zA:
0.0		 5kc4A-1b0zA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A 415
LEU A 266
ILE A 255
 None
 0.75A 5kc4A-1b8aA:
0.0		 5kc4A-1b8aA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		3 LYS A  37
LEU A  45
ILE A  10
 NAD  A 300 (-4.4A)
None
None
 0.74A 5kc4A-1bdbA:
0.0		 5kc4A-1bdbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 LYS A 130
LEU A  97
ILE A 123
 None
 0.67A 5kc4A-1bvsA:
undetectable		 5kc4A-1bvsA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		3 LYS A 158
LEU A 168
ILE A 151
 None
 0.82A 5kc4A-1c7oA:
0.0		 5kc4A-1c7oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 118
LEU A 167
ILE A 215
 None
 0.58A 5kc4A-1cm8A:
0.3		 5kc4A-1cm8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		3 LYS A 707
LEU A 741
ILE A 678
 None
 0.77A 5kc4A-1d2nA:
undetectable		 5kc4A-1d2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		3 LYS A 841
LEU A 826
ILE A 770
 None
 0.82A 5kc4A-1d5fA:
1.4		 5kc4A-1d5fA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN
TRANSLOCATED INTIMIN
RECEPTOR

(Escherichia
coli) 		PF02368
(Big_2)
PF02369
(Big_1)
PF03549
(Tir_receptor_M)
PF07979
(Intimin_C) 		3 LYS T 298
LEU I 923
ILE T 308
 None
 0.77A 5kc4A-1f02T:
undetectable		 5kc4A-1f02T:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 LYS A 204
LEU A 179
ILE A 192
 None
 0.65A 5kc4A-1fp2A:
undetectable		 5kc4A-1fp2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		3 LYS A 127
LEU A  81
ILE A 133
 None
 0.76A 5kc4A-1hxhA:
undetectable		 5kc4A-1hxhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihj INAD

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 LYS A  51
LEU A  65
ILE A  71
 None
 0.80A 5kc4A-1ihjA:
undetectable		 5kc4A-1ihjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS A 115
LEU A 119
ILE A  48
 None
 0.72A 5kc4A-1jpeA:
undetectable		 5kc4A-1jpeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzd THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS C 115
LEU C 119
ILE C  48
 None
 0.81A 5kc4A-1jzdC:
undetectable		 5kc4A-1jzdC:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		3 LYS A 396
LEU A 366
ILE A 315
 None
 0.61A 5kc4A-1kzhA:
undetectable		 5kc4A-1kzhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 LYS A 116
LEU A 376
ILE A 113
 None
 0.67A 5kc4A-1lwdA:
undetectable		 5kc4A-1lwdA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LYS A 298
LEU A 412
ILE A 295
 None
 0.72A 5kc4A-1lxtA:
undetectable		 5kc4A-1lxtA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		3 LYS A 273
LEU A 197
ILE A 270
 None
 0.82A 5kc4A-1musA:
1.0		 5kc4A-1musA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 LYS A  55
LEU A 288
ILE A  33
 None
 0.77A 5kc4A-1nj1A:
undetectable		 5kc4A-1nj1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF13302
(Acetyltransf_3) 		3 LYS A 116
LEU A 125
ILE A  68
 None
 0.68A 5kc4A-1nslA:
undetectable		 5kc4A-1nslA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		3 LYS A  10
LEU A  18
ILE A 142
 None
 0.70A 5kc4A-1o20A:
undetectable		 5kc4A-1o20A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 LYS A 803
LEU A 834
ILE A1130
 None
 0.74A 5kc4A-1ofeA:
undetectable		 5kc4A-1ofeA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7y 50S RIBOSOMAL
PROTEIN L31E

(Haloarcula
marismortui) 		PF01198
(Ribosomal_L31e) 		3 LYS Y  28
LEU Y  50
ILE Y  12
 A  A1729 ( 2.5A)
C  A1384 ( 4.3A)
None
 0.78A 5kc4A-1q7yY:
undetectable		 5kc4A-1q7yY:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 LYS A 440
LEU A 448
ILE A 376
 None
 0.83A 5kc4A-1qoxA:
undetectable		 5kc4A-1qoxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 LYS X 126
LEU X  44
ILE X 112
 None
 0.71A 5kc4A-1r6bX:
undetectable		 5kc4A-1r6bX:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 3 LYS P 614
LEU P 623
ILE P 605
 None
 0.82A 5kc4A-1r6zP:
undetectable		 5kc4A-1r6zP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LYS A 419
LEU A 359
ILE A 371
 None
 0.81A 5kc4A-1rp1A:
undetectable		 5kc4A-1rp1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 LYS A 175
LEU A 167
ILE A 216
 None
 0.80A 5kc4A-1rtrA:
1.7		 5kc4A-1rtrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 LYS A  64
LEU A  16
ILE A  40
 None
 0.69A 5kc4A-1sxlA:
undetectable		 5kc4A-1sxlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 LYS A 173
LEU A 132
ILE A  18
 None
 0.70A 5kc4A-1tcsA:
undetectable		 5kc4A-1tcsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		3 LYS A1386
LEU A1542
ILE A1493
 None
 0.74A 5kc4A-1ug3A:
undetectable		 5kc4A-1ug3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LYS A  54
LEU A  21
ILE A  14
 None
 0.75A 5kc4A-1vpkA:
undetectable		 5kc4A-1vpkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS36P, YLR417W

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		3 LYS D 496
LEU D 532
ILE D 503
 None
 0.78A 5kc4A-1w7pD:
undetectable		 5kc4A-1w7pD:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 LYS A  87
LEU A  46
ILE A 183
 None
 0.79A 5kc4A-1wczA:
undetectable		 5kc4A-1wczA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA) 		3 LYS A  18
LEU A  59
ILE A  39
 None
 0.57A 5kc4A-1wdwA:
undetectable		 5kc4A-1wdwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		3 LYS A 820
LEU A 930
ILE A 917
 None
 0.80A 5kc4A-1werA:
2.7		 5kc4A-1werA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgk RIKEN CDNA
2900073H19 PROTEIN

(Mus musculus) 		PF09138
(Urm1) 		3 LYS A  53
LEU A  36
ILE A  99
 None
 0.81A 5kc4A-1wgkA:
undetectable		 5kc4A-1wgkA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x53 ACTIVATOR OF 90 KDA
HEAT SHOCK PROTEIN
ATPASE HOMOLOG 1

(Homo sapiens) 		PF08327
(AHSA1) 		3 LYS A  77
LEU A  46
ILE A  74
 None
 0.82A 5kc4A-1x53A:
undetectable		 5kc4A-1x53A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk5 SNURPORTIN-1

(Homo sapiens) 		no annotation 3 LYS A 233
LEU A 258
ILE A 175
 None
TPG  A 400 (-4.6A)
None
 0.78A 5kc4A-1xk5A:
undetectable		 5kc4A-1xk5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		3 LYS A  78
LEU A  58
ILE A   8
 None
 0.77A 5kc4A-1xmpA:
undetectable		 5kc4A-1xmpA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 LYS A  32
LEU A   6
ILE A 130
 None
 0.70A 5kc4A-1xntA:
undetectable		 5kc4A-1xntA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxb ARGININE REPRESSOR

(Escherichia
coli) 		PF02863
(Arg_repressor_C) 		3 LYS A  83
LEU A 112
ILE A  89
 None
 0.79A 5kc4A-1xxbA:
undetectable		 5kc4A-1xxbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		3 LYS A  40
LEU A  44
ILE A  61
 None
 0.66A 5kc4A-1y51A:
undetectable		 5kc4A-1y51A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		3 LYS A 222
LEU A 245
ILE A 172
 None
 0.78A 5kc4A-1ybmA:
undetectable		 5kc4A-1ybmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6o ISHP608 TRANSPOSASE

(Helicobacter
pylori) 		PF01797
(Y1_Tnp) 		3 LYS A  82
LEU A 106
ILE A  43
 None
 0.79A 5kc4A-2a6oA:
undetectable		 5kc4A-2a6oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LYS A 198
LEU A 192
ILE A 205
 None
 0.76A 5kc4A-2ad1A:
undetectable		 5kc4A-2ad1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 LYS A 314
LEU A 322
ILE A 301
 None
 0.63A 5kc4A-2aeuA:
undetectable		 5kc4A-2aeuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		3 LYS A   7
LEU A 139
ILE A 148
 None
 0.76A 5kc4A-2aznA:
undetectable		 5kc4A-2aznA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0a HYPOTHETICAL PROTEIN
MJ0783

(Methanocaldococcus
jannaschii) 		PF04199
(Cyclase) 		3 LYS A 121
LEU A 140
ILE A  45
 None
 0.62A 5kc4A-2b0aA:
undetectable		 5kc4A-2b0aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1154
LEU A1087
ILE A1148
 None
 0.77A 5kc4A-2b39A:
undetectable		 5kc4A-2b39A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		3 LYS A 144
LEU A  93
ILE A 148
 None
 0.80A 5kc4A-2bgkA:
undetectable		 5kc4A-2bgkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 LYS A  36
LEU A  66
ILE A  43
 None
 0.69A 5kc4A-2c5sA:
undetectable		 5kc4A-2c5sA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 LYS A  64
LEU A   8
ILE A  68
 None
 0.83A 5kc4A-2c5uA:
undetectable		 5kc4A-2c5uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqr DNAJ HOMOLOG
SUBFAMILY C MEMBER 1

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		3 LYS A  46
LEU A  29
ILE A  60
 None
 0.82A 5kc4A-2cqrA:
undetectable		 5kc4A-2cqrA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		3 LYS A  29
LEU A 139
ILE A  69
 None
 0.65A 5kc4A-2csuA:
undetectable		 5kc4A-2csuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		3 LYS A 362
LEU A   4
ILE A 328
 None
 0.73A 5kc4A-2cxnA:
1.0		 5kc4A-2cxnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do3 TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW) 		3 LYS A 473
LEU A 518
ILE A 501
 None
 0.82A 5kc4A-2do3A:
undetectable		 5kc4A-2do3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		3 LYS A 183
LEU A  69
ILE A 166
 None
 0.81A 5kc4A-2e1tA:
undetectable		 5kc4A-2e1tA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejx STK_08120

(Sulfurisphaera
tokodaii) 		PF11485
(DUF3211) 		3 LYS A   9
LEU A 116
ILE A  85
 None
 0.79A 5kc4A-2ejxA:
undetectable		 5kc4A-2ejxA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqn HYPOTHETICAL PROTEIN
LOC92345

(Homo sapiens) 		PF04410
(Gar1) 		3 LYS A  66
LEU A  28
ILE A  70
 None
 0.83A 5kc4A-2eqnA:
undetectable		 5kc4A-2eqnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LYS A 104
LEU A 227
ILE A  43
 None
 0.79A 5kc4A-2fpqA:
undetectable		 5kc4A-2fpqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2q GLUTAREDOXIN-2

(Vaccinia virus) 		PF05768
(DUF836) 		3 LYS A  27
LEU A 107
ILE A   7
 None
 0.49A 5kc4A-2g2qA:
undetectable		 5kc4A-2g2qA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 280
LEU A 186
ILE A 273
 None
 0.82A 5kc4A-2g6zA:
undetectable		 5kc4A-2g6zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 LYS A  57
LEU A  68
ILE A  86
 None
 0.75A 5kc4A-2gerA:
undetectable		 5kc4A-2gerA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 LYS A  57
LEU A  68
ILE A  86
 None
 0.76A 5kc4A-2gr9A:
undetectable		 5kc4A-2gr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 LYS A 301
LEU A 307
ILE A 374
 None
 0.77A 5kc4A-2gwcA:
undetectable		 5kc4A-2gwcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		3 LYS A 203
LEU A 149
ILE A 209
 None
 0.78A 5kc4A-2h2wA:
undetectable		 5kc4A-2h2wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 LYS A 141
LEU A 134
ILE A 154
 None
 0.72A 5kc4A-2hekA:
undetectable		 5kc4A-2hekA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		3 LYS A 114
LEU A  84
ILE A 121
 None
 0.58A 5kc4A-2hj0A:
undetectable		 5kc4A-2hj0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A 142
LEU A 134
ILE A 128
 None
 0.81A 5kc4A-2hjrA:
0.6		 5kc4A-2hjrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 LYS A   4
LEU A  55
ILE A  96
 None
 0.80A 5kc4A-2hv2A:
undetectable		 5kc4A-2hv2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 391
LEU A 403
ILE A 462
 SEP  A 660 ( 3.7A)
None
None
 0.80A 5kc4A-2i0eA:
undetectable		 5kc4A-2i0eA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 LYS A  36
LEU A 174
ILE A  28
 None
 0.66A 5kc4A-2i7tA:
undetectable		 5kc4A-2i7tA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Rattus
norvegicus) 		PF05881
(CNPase) 		3 LYS A 103
LEU A  70
ILE A 106
 None
 0.68A 5kc4A-2ilxA:
undetectable		 5kc4A-2ilxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR

(Homo sapiens) 		PF11976
(Rad60-SLD) 		3 LYS B  41
LEU B  19
ILE B  66
 None
 0.82A 5kc4A-2io1B:
undetectable		 5kc4A-2io1B:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv8 AP-2 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2)
PF09066
(B2-adapt-app_C) 		3 LYS A 721
LEU A 776
ILE A 725
 None
 0.65A 5kc4A-2iv8A:
undetectable		 5kc4A-2iv8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LYS A  91
LEU A 275
ILE A  85
 None
 0.69A 5kc4A-2j1qA:
undetectable		 5kc4A-2j1qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		3 LYS A 106
LEU A  30
ILE A  39
 None
 0.72A 5kc4A-2j4lA:
undetectable		 5kc4A-2j4lA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j71 PULLULANASE

(Thermotoga
maritima) 		PF03714
(PUD) 		3 LYS A  55
LEU A  25
ILE A  83
 None
 0.77A 5kc4A-2j71A:
undetectable		 5kc4A-2j71A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40

(Saccharomyces
cerevisiae) 		PF15985
(KH_6) 		3 LYS A 197
LEU A 175
ILE A 194
 None
 0.82A 5kc4A-2ja9A:
undetectable		 5kc4A-2ja9A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpo PHEROMONE-BINDING
PROTEIN

(Antheraea
polyphemus) 		PF01395
(PBP_GOBP) 		3 LYS A  58
LEU A   8
ILE A 135
 None
 0.65A 5kc4A-2jpoA:
undetectable		 5kc4A-2jpoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvn POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF08063
(PADR1) 		3 LYS A 346
LEU A 252
ILE A 245
 None
 0.74A 5kc4A-2jvnA:
undetectable		 5kc4A-2jvnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		3 LYS A  32
LEU A 142
ILE A  55
 None
 0.79A 5kc4A-2k7hA:
undetectable		 5kc4A-2k7hA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7r PRIMOSOMAL PROTEIN
DNAI

(Bacillus
subtilis) 		PF07319
(DnaI_N) 		3 LYS A  39
LEU A  87
ILE A  50
 None
 0.76A 5kc4A-2k7rA:
undetectable		 5kc4A-2k7rA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kap RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF07647
(SAM_2) 		3 LYS A  55
LEU A  18
ILE A  28
 None
 0.79A 5kc4A-2kapA:
undetectable		 5kc4A-2kapA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Vibrio
parahaemolyticus) 		PF01035
(DNA_binding_1) 		3 LYS A  41
LEU A  52
ILE A  26
 None
 0.79A 5kc4A-2kifA:
undetectable		 5kc4A-2kifA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kos ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		3 LYS A  67
LEU A  11
ILE A  58
 None
SXO  A 101 ( 4.7A)
SXO  A 101 ( 4.3A)
 0.76A 5kc4A-2kosA:
undetectable		 5kc4A-2kosA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		3 LYS A  15
LEU A  70
ILE A 149
 None
 0.76A 5kc4A-2lfcA:
undetectable		 5kc4A-2lfcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4e PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio
vulnificus) 		PF16691
(DUF5062) 		3 LYS A  68
LEU A  48
ILE A  75
 None
 0.73A 5kc4A-2m4eA:
undetectable		 5kc4A-2m4eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlb REDESIGNED UBIQUITIN

(synthetic
construct) 		PF00240
(ubiquitin) 		3 LYS A  43
LEU A  27
ILE A  68
 None
 0.72A 5kc4A-2mlbA:
undetectable		 5kc4A-2mlbA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8l INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1

(Gallus gallus) 		PF00013
(KH_1) 		3 LYS A  40
LEU A  48
ILE A  37
 C  B   2 ( 4.8A)
None
None
 0.80A 5kc4A-2n8lA:
undetectable		 5kc4A-2n8lA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 LYS A 419
LEU A 422
ILE A 445
 None
 0.77A 5kc4A-2nrrA:
undetectable		 5kc4A-2nrrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		3 LYS A 163
LEU A 171
ILE A 155
 None
 0.80A 5kc4A-2nxfA:
undetectable		 5kc4A-2nxfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 LYS A  29
LEU A  22
ILE A  66
 None
 0.61A 5kc4A-2nygA:
undetectable		 5kc4A-2nygA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LYS A 208
LEU A 163
ILE A 247
 None
 0.74A 5kc4A-2o1vA:
undetectable		 5kc4A-2o1vA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		3 LYS A 243
LEU A 225
ILE A 257
 None
 0.82A 5kc4A-2olaA:
undetectable		 5kc4A-2olaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		3 LYS A   4
LEU A  49
ILE A 131
 None
 0.77A 5kc4A-2p0lA:
undetectable		 5kc4A-2p0lA:
21.99