SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC4_A_RBFA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.41A 5kc4A-1ao3A:
undetectable		 5kc4A-1ao3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 105
GLY A 108
ASN A 322
ASN A 386
ASN A 346
 None
 1.41A 5kc4A-1bf2A:
0.0		 5kc4A-1bf2A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.49A 5kc4A-1exbA:
undetectable		 5kc4A-1exbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs0 ATP SYNTHASE GAMMA
SUBUNIT

(Escherichia
coli) 		PF00231
(ATP-synt) 		5 GLU G 148
LEU G 149
ASP G  84
GLY G 119
ALA G 116
 None
 1.46A 5kc4A-1fs0G:
0.0		 5kc4A-1fs0G:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		5 ASP A 111
GLY A 117
MET A 120
ASN A 190
PHE A 181
 None
 1.44A 5kc4A-1hg2A:
0.5		 5kc4A-1hg2A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		5 ASP A 113
GLY A 130
MET A 133
ASN A 204
PHE A 195
 None
 1.42A 5kc4A-1hx8A:
1.7		 5kc4A-1hx8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLU A 273
LEU A 304
GLY A 241
ALA A 287
PHE A 319
 MG  A 901 (-2.8A)
None
None
None
None
 1.29A 5kc4A-1kczA:
0.0		 5kc4A-1kczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLU A 271
GLY A 298
ASN A 293
ALA A 330
ASN A 275
 None
None
None
NAI  A 920 (-3.5A)
NAI  A 920 (-3.1A)
 1.06A 5kc4A-1o0sA:
0.0		 5kc4A-1o0sA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		5 GLU A 319
LEU A 321
GLY A 207
MET A 210
ALA A 305
 None
 0.91A 5kc4A-1pmiA:
undetectable		 5kc4A-1pmiA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 GLU A 166
LEU A 208
GLY A 233
ASN A   9
ALA A  38
 None
None
PO4  A2004 (-3.2A)
None
None
 1.32A 5kc4A-1yyaA:
undetectable		 5kc4A-1yyaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 GLU A  86
LEU A  81
ASP A  90
GLY A  93
ALA A  26
 None
 1.23A 5kc4A-1zagA:
undetectable		 5kc4A-1zagA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 170
GLY B 103
MET B  68
ASN B  67
ALA B  62
 None
 1.15A 5kc4A-2f2aB:
undetectable		 5kc4A-2f2aB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 LEU A 280
LYS A 170
ASP A 214
GLY A 213
ALA A  19
 None
 1.33A 5kc4A-2o5rA:
undetectable		 5kc4A-2o5rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 216
ASP A  37
GLY A  82
ASN A 140
PHE A 188
 None
ZN  A5647 (-3.0A)
None
None
None
 1.30A 5kc4A-2z1aA:
undetectable		 5kc4A-2z1aA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASP A1442
ASN A1273
ALA A1279
ASN A1255
PHE A1222
 MN  A   4 (-2.3A)
MPD  A1695 (-4.4A)
None
None
None
 1.31A 5kc4A-2zxqA:
undetectable		 5kc4A-2zxqA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 GLU A 159
GLY A 221
ASN A 203
ALA A 217
ASN A 229
 None
CA  A 351 ( 4.6A)
PQQ  A4331 (-3.9A)
None
CA  A 350 ( 4.4A)
 1.00A 5kc4A-3dasA:
undetectable		 5kc4A-3dasA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.40A 5kc4A-3jzjA:
undetectable		 5kc4A-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLU A 295
LEU A 283
GLY A 324
ALA A  20
ASN A 279
 None
 1.43A 5kc4A-3k17A:
undetectable		 5kc4A-3k17A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 GLU A  53
GLY A  45
ASN A  44
ALA A  75
ASN A 407
 None
 1.39A 5kc4A-3k2qA:
undetectable		 5kc4A-3k2qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		5 GLY A 366
MET A 325
ASN A 324
ALA A  62
ASN A 272
 None
 1.24A 5kc4A-3n8uA:
1.8		 5kc4A-3n8uA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 GLU A 200
LEU A 204
GLY A 197
ALA A  54
PHE A 276
 None
 1.47A 5kc4A-3p41A:
2.8		 5kc4A-3p41A:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		7 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.04A 5kc4A-3p5nA:
23.6		 5kc4A-3p5nA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 GLU A  78
LEU A 143
ASP A  68
GLY A  65
ALA A  56
 CA  A 340 ( 4.5A)
None
CA  A 340 (-3.0A)
None
None
 1.28A 5kc4A-3q3uA:
undetectable		 5kc4A-3q3uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 GLU A 416
LEU A 444
GLY A 323
ALA A 477
PHE A 183
 None
 1.45A 5kc4A-3qanA:
undetectable		 5kc4A-3qanA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00008
(EGF)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 344
ASP G  45
GLY G  44
ASN A 378
PHE A 376
 None
 1.33A 5kc4A-3u7uA:
undetectable		 5kc4A-3u7uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 GLU A 126
LEU A 121
ASP A  64
GLY A  63
PHE A 118
 None
None
MN  A 402 (-3.0A)
None
None
 1.33A 5kc4A-3v4yA:
undetectable		 5kc4A-3v4yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLU A 279
LEU A 257
MET A 267
ASN A 265
ALA A 329
 None
 1.23A 5kc4A-3vf1A:
1.2		 5kc4A-3vf1A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 GLU A 177
LEU A 293
ASP A 247
GLY A 246
LYS A 171
 None
 1.41A 5kc4A-3zxsA:
undetectable		 5kc4A-3zxsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LEU A  78
MET A 125
ALA A  89
ASN A  86
PHE A 138
 None
 1.32A 5kc4A-4dq1A:
undetectable		 5kc4A-4dq1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLU A 331
LEU A 201
GLY A 176
ASN A 177
ALA A 209
 None
 1.42A 5kc4A-4eexA:
undetectable		 5kc4A-4eexA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLY A 230
ASN A 229
ALA A 200
ASN A 101
ASN A 257
 None
None
TRS  A 601 ( 4.0A)
None
None
 1.40A 5kc4A-4m8uA:
undetectable		 5kc4A-4m8uA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 GLU A 164
LEU A 205
GLY A 230
ASN A  11
ALA A  41
 CA  A 305 (-3.1A)
None
SO4  A 301 (-3.4A)
CA  A 305 (-4.2A)
None
 1.37A 5kc4A-4y90A:
undetectable		 5kc4A-4y90A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 GLU A 977
GLY A 972
ALA A1041
ASN A1042
ASN A1006
 None
 1.32A 5kc4A-5b16A:
undetectable		 5kc4A-5b16A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		5 GLY A 230
MET A 191
ASN A 190
ALA A 158
ASN A 147
 None
 1.49A 5kc4A-5ewqA:
undetectable		 5kc4A-5ewqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		5 GLU A 142
ASP A 168
GLY A 270
MET A 273
ALA A 293
 None
 1.37A 5kc4A-5exeA:
undetectable		 5kc4A-5exeA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU B  29
ASP B 217
ASN B 251
ALA B  22
ASN B 117
 None
None
None
EDO  B 403 (-3.6A)
None
 1.48A 5kc4A-5f38B:
undetectable		 5kc4A-5f38B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 LEU A2212
ASP A2259
GLY A2262
ALA A2269
ASN A2216
 None
 1.22A 5kc4A-5fu7A:
0.8		 5kc4A-5fu7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 GLU A  62
ASP A 262
GLY A 238
ASN A 240
ASN A  55
 None
None
None
NO3  A 405 (-3.9A)
None
 1.44A 5kc4A-5jt8A:
undetectable		 5kc4A-5jt8A:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		6 GLU A  24
LEU A  34
ASP A  73
GLY A  76
MET A  79
ASN A 123
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
RBF  A 201 (-2.1A)
 0.89A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		11 LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.62A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel C13C6 VARIABLE FAB
DOMAIN HEAVY CHAIN
EBOLA SURFACE
GLYCOPROTEIN, GP1

(Homo sapiens;
Zaire
ebolavirus) 		PF01611
(Filo_glycop)
PF07686
(V-set) 		5 LEU A 273
ASP C  54
GLY C  33
ALA C 100
ASN C 100
 None
 1.31A 5kc4A-5kelA:
undetectable		 5kc4A-5kelA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LYS B 395
ASP B 344
GLY B 349
ASN B 554
ASN B 316
 None
 1.49A 5kc4A-5mrwB:
1.6		 5kc4A-5mrwB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 361
GLY A 358
ALA A 434
ASN A 443
PHE A 431
 None
 0.93A 5kc4A-5opjA:
undetectable		 5kc4A-5opjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 GLU A 889
LEU A 887
ASP A 840
ALA A 864
PHE A 857
 None
 1.15A 5kc4A-5ve8A:
2.1		 5kc4A-5ve8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLU C 945
GLY C 909
ASN C 908
ALA C 834
ASN C 835
 None
 1.46A 5kc4A-5x6oC:
2.6		 5kc4A-5x6oC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 GLU A 334
LEU A 454
ASN A 452
ASN A 435
LYS A 411
 None
 1.35A 5kc4A-5xt3A:
undetectable		 5kc4A-5xt3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii) 		no annotation 5 GLU C 107
ASP A 367
GLY A 363
ASN A  36
ALA A  50
 None
 1.19A 5kc4A-6feaC:
2.6		 5kc4A-6feaC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 GLU A 194
ASP A 298
GLY A 300
ALA A 224
PHE A 228
 None
 1.48A 5kc4A-6gh2A:
undetectable		 5kc4A-6gh2A:
20.41