SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC4_A_RBFA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.41A 5kc4A-1ao3A:
undetectable		 5kc4A-1ao3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 105
GLY A 108
ASN A 322
ASN A 386
ASN A 346
 None
 1.41A 5kc4A-1bf2A:
0.0		 5kc4A-1bf2A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.49A 5kc4A-1exbA:
undetectable		 5kc4A-1exbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs0 ATP SYNTHASE GAMMA
SUBUNIT

(Escherichia
coli) 		PF00231
(ATP-synt) 		5 GLU G 148
LEU G 149
ASP G  84
GLY G 119
ALA G 116
 None
 1.46A 5kc4A-1fs0G:
0.0		 5kc4A-1fs0G:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		5 ASP A 111
GLY A 117
MET A 120
ASN A 190
PHE A 181
 None
 1.44A 5kc4A-1hg2A:
0.5		 5kc4A-1hg2A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		5 ASP A 113
GLY A 130
MET A 133
ASN A 204
PHE A 195
 None
 1.42A 5kc4A-1hx8A:
1.7		 5kc4A-1hx8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLU A 273
LEU A 304
GLY A 241
ALA A 287
PHE A 319
 MG  A 901 (-2.8A)
None
None
None
None
 1.29A 5kc4A-1kczA:
0.0		 5kc4A-1kczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLU A 271
GLY A 298
ASN A 293
ALA A 330
ASN A 275
 None
None
None
NAI  A 920 (-3.5A)
NAI  A 920 (-3.1A)
 1.06A 5kc4A-1o0sA:
0.0		 5kc4A-1o0sA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		5 GLU A 319
LEU A 321
GLY A 207
MET A 210
ALA A 305
 None
 0.91A 5kc4A-1pmiA:
undetectable		 5kc4A-1pmiA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 GLU A 166
LEU A 208
GLY A 233
ASN A   9
ALA A  38
 None
None
PO4  A2004 (-3.2A)
None
None
 1.32A 5kc4A-1yyaA:
undetectable		 5kc4A-1yyaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 GLU A  86
LEU A  81
ASP A  90
GLY A  93
ALA A  26
 None
 1.23A 5kc4A-1zagA:
undetectable		 5kc4A-1zagA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 170
GLY B 103
MET B  68
ASN B  67
ALA B  62
 None
 1.15A 5kc4A-2f2aB:
undetectable		 5kc4A-2f2aB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 LEU A 280
LYS A 170
ASP A 214
GLY A 213
ALA A  19
 None
 1.33A 5kc4A-2o5rA:
undetectable		 5kc4A-2o5rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 216
ASP A  37
GLY A  82
ASN A 140
PHE A 188
 None
ZN  A5647 (-3.0A)
None
None
None
 1.30A 5kc4A-2z1aA:
undetectable		 5kc4A-2z1aA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASP A1442
ASN A1273
ALA A1279
ASN A1255
PHE A1222
 MN  A   4 (-2.3A)
MPD  A1695 (-4.4A)
None
None
None
 1.31A 5kc4A-2zxqA:
undetectable		 5kc4A-2zxqA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 GLU A 159
GLY A 221
ASN A 203
ALA A 217
ASN A 229
 None
CA  A 351 ( 4.6A)
PQQ  A4331 (-3.9A)
None
CA  A 350 ( 4.4A)
 1.00A 5kc4A-3dasA:
undetectable		 5kc4A-3dasA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.40A 5kc4A-3jzjA:
undetectable		 5kc4A-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLU A 295
LEU A 283
GLY A 324
ALA A  20
ASN A 279
 None
 1.43A 5kc4A-3k17A:
undetectable		 5kc4A-3k17A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 GLU A  53
GLY A  45
ASN A  44
ALA A  75
ASN A 407
 None
 1.39A 5kc4A-3k2qA:
undetectable		 5kc4A-3k2qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		5 GLY A 366
MET A 325
ASN A 324
ALA A  62
ASN A 272
 None
 1.24A 5kc4A-3n8uA:
1.8		 5kc4A-3n8uA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 GLU A 200
LEU A 204
GLY A 197
ALA A  54
PHE A 276
 None
 1.47A 5kc4A-3p41A:
2.8		 5kc4A-3p41A:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		7 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.04A 5kc4A-3p5nA:
23.6		 5kc4A-3p5nA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 GLU A  78
LEU A 143
ASP A  68
GLY A  65
ALA A  56
 CA  A 340 ( 4.5A)
None
CA  A 340 (-3.0A)
None
None
 1.28A 5kc4A-3q3uA:
undetectable		 5kc4A-3q3uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 GLU A 416
LEU A 444
GLY A 323
ALA A 477
PHE A 183
 None
 1.45A 5kc4A-3qanA:
undetectable		 5kc4A-3qanA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00008
(EGF)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 344
ASP G  45
GLY G  44
ASN A 378
PHE A 376
 None
 1.33A 5kc4A-3u7uA:
undetectable		 5kc4A-3u7uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 GLU A 126
LEU A 121
ASP A  64
GLY A  63
PHE A 118
 None
None
MN  A 402 (-3.0A)
None
None
 1.33A 5kc4A-3v4yA:
undetectable		 5kc4A-3v4yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLU A 279
LEU A 257
MET A 267
ASN A 265
ALA A 329
 None
 1.23A 5kc4A-3vf1A:
1.2		 5kc4A-3vf1A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 GLU A 177
LEU A 293
ASP A 247
GLY A 246
LYS A 171
 None
 1.41A 5kc4A-3zxsA:
undetectable		 5kc4A-3zxsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LEU A  78
MET A 125
ALA A  89
ASN A  86
PHE A 138
 None
 1.32A 5kc4A-4dq1A:
undetectable		 5kc4A-4dq1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLU A 331
LEU A 201
GLY A 176
ASN A 177
ALA A 209
 None
 1.42A 5kc4A-4eexA:
undetectable		 5kc4A-4eexA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLY A 230
ASN A 229
ALA A 200
ASN A 101
ASN A 257
 None
None
TRS  A 601 ( 4.0A)
None
None
 1.40A 5kc4A-4m8uA:
undetectable		 5kc4A-4m8uA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 GLU A 164
LEU A 205
GLY A 230
ASN A  11
ALA A  41
 CA  A 305 (-3.1A)
None
SO4  A 301 (-3.4A)
CA  A 305 (-4.2A)
None
 1.37A 5kc4A-4y90A:
undetectable		 5kc4A-4y90A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 GLU A 977
GLY A 972
ALA A1041
ASN A1042
ASN A1006
 None
 1.32A 5kc4A-5b16A:
undetectable		 5kc4A-5b16A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		5 GLY A 230
MET A 191
ASN A 190
ALA A 158
ASN A 147
 None
 1.49A 5kc4A-5ewqA:
undetectable		 5kc4A-5ewqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		5 GLU A 142
ASP A 168
GLY A 270
MET A 273
ALA A 293
 None
 1.37A 5kc4A-5exeA:
undetectable		 5kc4A-5exeA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU B  29
ASP B 217
ASN B 251
ALA B  22
ASN B 117
 None
None
None
EDO  B 403 (-3.6A)
None
 1.48A 5kc4A-5f38B:
undetectable		 5kc4A-5f38B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 LEU A2212
ASP A2259
GLY A2262
ALA A2269
ASN A2216
 None
 1.22A 5kc4A-5fu7A:
0.8		 5kc4A-5fu7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 GLU A  62
ASP A 262
GLY A 238
ASN A 240
ASN A  55
 None
None
None
NO3  A 405 (-3.9A)
None
 1.44A 5kc4A-5jt8A:
undetectable		 5kc4A-5jt8A:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		6 GLU A  24
LEU A  34
ASP A  73
GLY A  76
MET A  79
ASN A 123
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
RBF  A 201 (-2.1A)
 0.89A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		11 LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.62A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel C13C6 VARIABLE FAB
DOMAIN HEAVY CHAIN
EBOLA SURFACE
GLYCOPROTEIN, GP1

(Homo sapiens;
Zaire
ebolavirus) 		PF01611
(Filo_glycop)
PF07686
(V-set) 		5 LEU A 273
ASP C  54
GLY C  33
ALA C 100
ASN C 100
 None
 1.31A 5kc4A-5kelA:
undetectable		 5kc4A-5kelA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LYS B 395
ASP B 344
GLY B 349
ASN B 554
ASN B 316
 None
 1.49A 5kc4A-5mrwB:
1.6		 5kc4A-5mrwB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 361
GLY A 358
ALA A 434
ASN A 443
PHE A 431
 None
 0.93A 5kc4A-5opjA:
undetectable		 5kc4A-5opjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 GLU A 889
LEU A 887
ASP A 840
ALA A 864
PHE A 857
 None
 1.15A 5kc4A-5ve8A:
2.1		 5kc4A-5ve8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLU C 945
GLY C 909
ASN C 908
ALA C 834
ASN C 835
 None
 1.46A 5kc4A-5x6oC:
2.6		 5kc4A-5x6oC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 GLU A 334
LEU A 454
ASN A 452
ASN A 435
LYS A 411
 None
 1.35A 5kc4A-5xt3A:
undetectable		 5kc4A-5xt3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii) 		no annotation 5 GLU C 107
ASP A 367
GLY A 363
ASN A  36
ALA A  50
 None
 1.19A 5kc4A-6feaC:
2.6		 5kc4A-6feaC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 GLU A 194
ASP A 298
GLY A 300
ALA A 224
PHE A 228
 None
 1.48A 5kc4A-6gh2A:
undetectable		 5kc4A-6gh2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A  39
LEU A 110
ILE A 207
 None
 0.80A 5kc4A-1amuA:
0.0		 5kc4A-1amuA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LYS A  58
LEU A 198
ILE A  61
 None
 0.82A 5kc4A-1aorA:
0.0		 5kc4A-1aorA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 LYS A  13
LEU A   5
ILE A 229
 None
 0.79A 5kc4A-1atiA:
0.0		 5kc4A-1atiA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		3 LYS A 159
LEU A 127
ILE A 134
 None
 0.79A 5kc4A-1b0zA:
0.0		 5kc4A-1b0zA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A 415
LEU A 266
ILE A 255
 None
 0.75A 5kc4A-1b8aA:
0.0		 5kc4A-1b8aA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		3 LYS A  37
LEU A  45
ILE A  10
 NAD  A 300 (-4.4A)
None
None
 0.74A 5kc4A-1bdbA:
0.0		 5kc4A-1bdbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 LYS A 130
LEU A  97
ILE A 123
 None
 0.67A 5kc4A-1bvsA:
undetectable		 5kc4A-1bvsA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		3 LYS A 158
LEU A 168
ILE A 151
 None
 0.82A 5kc4A-1c7oA:
0.0		 5kc4A-1c7oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 118
LEU A 167
ILE A 215
 None
 0.58A 5kc4A-1cm8A:
0.3		 5kc4A-1cm8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		3 LYS A 707
LEU A 741
ILE A 678
 None
 0.77A 5kc4A-1d2nA:
undetectable		 5kc4A-1d2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		3 LYS A 841
LEU A 826
ILE A 770
 None
 0.82A 5kc4A-1d5fA:
1.4		 5kc4A-1d5fA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN
TRANSLOCATED INTIMIN
RECEPTOR

(Escherichia
coli) 		PF02368
(Big_2)
PF02369
(Big_1)
PF03549
(Tir_receptor_M)
PF07979
(Intimin_C) 		3 LYS T 298
LEU I 923
ILE T 308
 None
 0.77A 5kc4A-1f02T:
undetectable		 5kc4A-1f02T:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 LYS A 204
LEU A 179
ILE A 192
 None
 0.65A 5kc4A-1fp2A:
undetectable		 5kc4A-1fp2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		3 LYS A 127
LEU A  81
ILE A 133
 None
 0.76A 5kc4A-1hxhA:
undetectable		 5kc4A-1hxhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihj INAD

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 LYS A  51
LEU A  65
ILE A  71
 None
 0.80A 5kc4A-1ihjA:
undetectable		 5kc4A-1ihjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS A 115
LEU A 119
ILE A  48
 None
 0.72A 5kc4A-1jpeA:
undetectable		 5kc4A-1jpeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzd THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS C 115
LEU C 119
ILE C  48
 None
 0.81A 5kc4A-1jzdC:
undetectable		 5kc4A-1jzdC:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		3 LYS A 396
LEU A 366
ILE A 315
 None
 0.61A 5kc4A-1kzhA:
undetectable		 5kc4A-1kzhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 LYS A 116
LEU A 376
ILE A 113
 None
 0.67A 5kc4A-1lwdA:
undetectable		 5kc4A-1lwdA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LYS A 298
LEU A 412
ILE A 295
 None
 0.72A 5kc4A-1lxtA:
undetectable		 5kc4A-1lxtA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		3 LYS A 273
LEU A 197
ILE A 270
 None
 0.82A 5kc4A-1musA:
1.0		 5kc4A-1musA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 LYS A  55
LEU A 288
ILE A  33
 None
 0.77A 5kc4A-1nj1A:
undetectable		 5kc4A-1nj1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF13302
(Acetyltransf_3) 		3 LYS A 116
LEU A 125
ILE A  68
 None
 0.68A 5kc4A-1nslA:
undetectable		 5kc4A-1nslA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		3 LYS A  10
LEU A  18
ILE A 142
 None
 0.70A 5kc4A-1o20A:
undetectable		 5kc4A-1o20A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 LYS A 803
LEU A 834
ILE A1130
 None
 0.74A 5kc4A-1ofeA:
undetectable		 5kc4A-1ofeA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7y 50S RIBOSOMAL
PROTEIN L31E

(Haloarcula
marismortui) 		PF01198
(Ribosomal_L31e) 		3 LYS Y  28
LEU Y  50
ILE Y  12
 A  A1729 ( 2.5A)
C  A1384 ( 4.3A)
None
 0.78A 5kc4A-1q7yY:
undetectable		 5kc4A-1q7yY:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 LYS A 440
LEU A 448
ILE A 376
 None
 0.83A 5kc4A-1qoxA:
undetectable		 5kc4A-1qoxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 LYS X 126
LEU X  44
ILE X 112
 None
 0.71A 5kc4A-1r6bX:
undetectable		 5kc4A-1r6bX:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 3 LYS P 614
LEU P 623
ILE P 605
 None
 0.82A 5kc4A-1r6zP:
undetectable		 5kc4A-1r6zP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LYS A 419
LEU A 359
ILE A 371
 None
 0.81A 5kc4A-1rp1A:
undetectable		 5kc4A-1rp1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 LYS A 175
LEU A 167
ILE A 216
 None
 0.80A 5kc4A-1rtrA:
1.7		 5kc4A-1rtrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 LYS A  64
LEU A  16
ILE A  40
 None
 0.69A 5kc4A-1sxlA:
undetectable		 5kc4A-1sxlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 LYS A 173
LEU A 132
ILE A  18
 None
 0.70A 5kc4A-1tcsA:
undetectable		 5kc4A-1tcsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		3 LYS A1386
LEU A1542
ILE A1493
 None
 0.74A 5kc4A-1ug3A:
undetectable		 5kc4A-1ug3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LYS A  54
LEU A  21
ILE A  14
 None
 0.75A 5kc4A-1vpkA:
undetectable		 5kc4A-1vpkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS36P, YLR417W

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		3 LYS D 496
LEU D 532
ILE D 503
 None
 0.78A 5kc4A-1w7pD:
undetectable		 5kc4A-1w7pD:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 LYS A  87
LEU A  46
ILE A 183
 None
 0.79A 5kc4A-1wczA:
undetectable		 5kc4A-1wczA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA) 		3 LYS A  18
LEU A  59
ILE A  39
 None
 0.57A 5kc4A-1wdwA:
undetectable		 5kc4A-1wdwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		3 LYS A 820
LEU A 930
ILE A 917
 None
 0.80A 5kc4A-1werA:
2.7		 5kc4A-1werA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgk RIKEN CDNA
2900073H19 PROTEIN

(Mus musculus) 		PF09138
(Urm1) 		3 LYS A  53
LEU A  36
ILE A  99
 None
 0.81A 5kc4A-1wgkA:
undetectable		 5kc4A-1wgkA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x53 ACTIVATOR OF 90 KDA
HEAT SHOCK PROTEIN
ATPASE HOMOLOG 1

(Homo sapiens) 		PF08327
(AHSA1) 		3 LYS A  77
LEU A  46
ILE A  74
 None
 0.82A 5kc4A-1x53A:
undetectable		 5kc4A-1x53A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk5 SNURPORTIN-1

(Homo sapiens) 		no annotation 3 LYS A 233
LEU A 258
ILE A 175
 None
TPG  A 400 (-4.6A)
None
 0.78A 5kc4A-1xk5A:
undetectable		 5kc4A-1xk5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		3 LYS A  78
LEU A  58
ILE A   8
 None
 0.77A 5kc4A-1xmpA:
undetectable		 5kc4A-1xmpA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 LYS A  32
LEU A   6
ILE A 130
 None
 0.70A 5kc4A-1xntA:
undetectable		 5kc4A-1xntA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxb ARGININE REPRESSOR

(Escherichia
coli) 		PF02863
(Arg_repressor_C) 		3 LYS A  83
LEU A 112
ILE A  89
 None
 0.79A 5kc4A-1xxbA:
undetectable		 5kc4A-1xxbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		3 LYS A  40
LEU A  44
ILE A  61
 None
 0.66A 5kc4A-1y51A:
undetectable		 5kc4A-1y51A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		3 LYS A 222
LEU A 245
ILE A 172
 None
 0.78A 5kc4A-1ybmA:
undetectable		 5kc4A-1ybmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6o ISHP608 TRANSPOSASE

(Helicobacter
pylori) 		PF01797
(Y1_Tnp) 		3 LYS A  82
LEU A 106
ILE A  43
 None
 0.79A 5kc4A-2a6oA:
undetectable		 5kc4A-2a6oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LYS A 198
LEU A 192
ILE A 205
 None
 0.76A 5kc4A-2ad1A:
undetectable		 5kc4A-2ad1A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 LYS A 314
LEU A 322
ILE A 301
 None
 0.63A 5kc4A-2aeuA:
undetectable		 5kc4A-2aeuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		3 LYS A   7
LEU A 139
ILE A 148
 None
 0.76A 5kc4A-2aznA:
undetectable		 5kc4A-2aznA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0a HYPOTHETICAL PROTEIN
MJ0783

(Methanocaldococcus
jannaschii) 		PF04199
(Cyclase) 		3 LYS A 121
LEU A 140
ILE A  45
 None
 0.62A 5kc4A-2b0aA:
undetectable		 5kc4A-2b0aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1154
LEU A1087
ILE A1148
 None
 0.77A 5kc4A-2b39A:
undetectable		 5kc4A-2b39A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		3 LYS A 144
LEU A  93
ILE A 148
 None
 0.80A 5kc4A-2bgkA:
undetectable		 5kc4A-2bgkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 LYS A  36
LEU A  66
ILE A  43
 None
 0.69A 5kc4A-2c5sA:
undetectable		 5kc4A-2c5sA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 LYS A  64
LEU A   8
ILE A  68
 None
 0.83A 5kc4A-2c5uA:
undetectable		 5kc4A-2c5uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqr DNAJ HOMOLOG
SUBFAMILY C MEMBER 1

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		3 LYS A  46
LEU A  29
ILE A  60
 None
 0.82A 5kc4A-2cqrA:
undetectable		 5kc4A-2cqrA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		3 LYS A  29
LEU A 139
ILE A  69
 None
 0.65A 5kc4A-2csuA:
undetectable		 5kc4A-2csuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		3 LYS A 362
LEU A   4
ILE A 328
 None
 0.73A 5kc4A-2cxnA:
1.0		 5kc4A-2cxnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do3 TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW) 		3 LYS A 473
LEU A 518
ILE A 501
 None
 0.82A 5kc4A-2do3A:
undetectable		 5kc4A-2do3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		3 LYS A 183
LEU A  69
ILE A 166
 None
 0.81A 5kc4A-2e1tA:
undetectable		 5kc4A-2e1tA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejx STK_08120

(Sulfurisphaera
tokodaii) 		PF11485
(DUF3211) 		3 LYS A   9
LEU A 116
ILE A  85
 None
 0.79A 5kc4A-2ejxA:
undetectable		 5kc4A-2ejxA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqn HYPOTHETICAL PROTEIN
LOC92345

(Homo sapiens) 		PF04410
(Gar1) 		3 LYS A  66
LEU A  28
ILE A  70
 None
 0.83A 5kc4A-2eqnA:
undetectable		 5kc4A-2eqnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LYS A 104
LEU A 227
ILE A  43
 None
 0.79A 5kc4A-2fpqA:
undetectable		 5kc4A-2fpqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2q GLUTAREDOXIN-2

(Vaccinia virus) 		PF05768
(DUF836) 		3 LYS A  27
LEU A 107
ILE A   7
 None
 0.49A 5kc4A-2g2qA:
undetectable		 5kc4A-2g2qA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 280
LEU A 186
ILE A 273
 None
 0.82A 5kc4A-2g6zA:
undetectable		 5kc4A-2g6zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 LYS A  57
LEU A  68
ILE A  86
 None
 0.75A 5kc4A-2gerA:
undetectable		 5kc4A-2gerA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 LYS A  57
LEU A  68
ILE A  86
 None
 0.76A 5kc4A-2gr9A:
undetectable		 5kc4A-2gr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 LYS A 301
LEU A 307
ILE A 374
 None
 0.77A 5kc4A-2gwcA:
undetectable		 5kc4A-2gwcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		3 LYS A 203
LEU A 149
ILE A 209
 None
 0.78A 5kc4A-2h2wA:
undetectable		 5kc4A-2h2wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 LYS A 141
LEU A 134
ILE A 154
 None
 0.72A 5kc4A-2hekA:
undetectable		 5kc4A-2hekA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		3 LYS A 114
LEU A  84
ILE A 121
 None
 0.58A 5kc4A-2hj0A:
undetectable		 5kc4A-2hj0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A 142
LEU A 134
ILE A 128
 None
 0.81A 5kc4A-2hjrA:
0.6		 5kc4A-2hjrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 LYS A   4
LEU A  55
ILE A  96
 None
 0.80A 5kc4A-2hv2A:
undetectable		 5kc4A-2hv2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 391
LEU A 403
ILE A 462
 SEP  A 660 ( 3.7A)
None
None
 0.80A 5kc4A-2i0eA:
undetectable		 5kc4A-2i0eA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 LYS A  36
LEU A 174
ILE A  28
 None
 0.66A 5kc4A-2i7tA:
undetectable		 5kc4A-2i7tA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Rattus
norvegicus) 		PF05881
(CNPase) 		3 LYS A 103
LEU A  70
ILE A 106
 None
 0.68A 5kc4A-2ilxA:
undetectable		 5kc4A-2ilxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2io1 SMALL
UBIQUITIN-RELATED
MODIFIER 3 PRECURSOR

(Homo sapiens) 		PF11976
(Rad60-SLD) 		3 LYS B  41
LEU B  19
ILE B  66
 None
 0.82A 5kc4A-2io1B:
undetectable		 5kc4A-2io1B:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv8 AP-2 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2)
PF09066
(B2-adapt-app_C) 		3 LYS A 721
LEU A 776
ILE A 725
 None
 0.65A 5kc4A-2iv8A:
undetectable		 5kc4A-2iv8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LYS A  91
LEU A 275
ILE A  85
 None
 0.69A 5kc4A-2j1qA:
undetectable		 5kc4A-2j1qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		3 LYS A 106
LEU A  30
ILE A  39
 None
 0.72A 5kc4A-2j4lA:
undetectable		 5kc4A-2j4lA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j71 PULLULANASE

(Thermotoga
maritima) 		PF03714
(PUD) 		3 LYS A  55
LEU A  25
ILE A  83
 None
 0.77A 5kc4A-2j71A:
undetectable		 5kc4A-2j71A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40

(Saccharomyces
cerevisiae) 		PF15985
(KH_6) 		3 LYS A 197
LEU A 175
ILE A 194
 None
 0.82A 5kc4A-2ja9A:
undetectable		 5kc4A-2ja9A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpo PHEROMONE-BINDING
PROTEIN

(Antheraea
polyphemus) 		PF01395
(PBP_GOBP) 		3 LYS A  58
LEU A   8
ILE A 135
 None
 0.65A 5kc4A-2jpoA:
undetectable		 5kc4A-2jpoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvn POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF08063
(PADR1) 		3 LYS A 346
LEU A 252
ILE A 245
 None
 0.74A 5kc4A-2jvnA:
undetectable		 5kc4A-2jvnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		3 LYS A  32
LEU A 142
ILE A  55
 None
 0.79A 5kc4A-2k7hA:
undetectable		 5kc4A-2k7hA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7r PRIMOSOMAL PROTEIN
DNAI

(Bacillus
subtilis) 		PF07319
(DnaI_N) 		3 LYS A  39
LEU A  87
ILE A  50
 None
 0.76A 5kc4A-2k7rA:
undetectable		 5kc4A-2k7rA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kap RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF07647
(SAM_2) 		3 LYS A  55
LEU A  18
ILE A  28
 None
 0.79A 5kc4A-2kapA:
undetectable		 5kc4A-2kapA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Vibrio
parahaemolyticus) 		PF01035
(DNA_binding_1) 		3 LYS A  41
LEU A  52
ILE A  26
 None
 0.79A 5kc4A-2kifA:
undetectable		 5kc4A-2kifA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kos ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		3 LYS A  67
LEU A  11
ILE A  58
 None
SXO  A 101 ( 4.7A)
SXO  A 101 ( 4.3A)
 0.76A 5kc4A-2kosA:
undetectable		 5kc4A-2kosA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		3 LYS A  15
LEU A  70
ILE A 149
 None
 0.76A 5kc4A-2lfcA:
undetectable		 5kc4A-2lfcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4e PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio
vulnificus) 		PF16691
(DUF5062) 		3 LYS A  68
LEU A  48
ILE A  75
 None
 0.73A 5kc4A-2m4eA:
undetectable		 5kc4A-2m4eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlb REDESIGNED UBIQUITIN

(synthetic
construct) 		PF00240
(ubiquitin) 		3 LYS A  43
LEU A  27
ILE A  68
 None
 0.72A 5kc4A-2mlbA:
undetectable		 5kc4A-2mlbA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8l INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1

(Gallus gallus) 		PF00013
(KH_1) 		3 LYS A  40
LEU A  48
ILE A  37
 C  B   2 ( 4.8A)
None
None
 0.80A 5kc4A-2n8lA:
undetectable		 5kc4A-2n8lA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 LYS A 419
LEU A 422
ILE A 445
 None
 0.77A 5kc4A-2nrrA:
undetectable		 5kc4A-2nrrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		3 LYS A 163
LEU A 171
ILE A 155
 None
 0.80A 5kc4A-2nxfA:
undetectable		 5kc4A-2nxfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 LYS A  29
LEU A  22
ILE A  66
 None
 0.61A 5kc4A-2nygA:
undetectable		 5kc4A-2nygA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LYS A 208
LEU A 163
ILE A 247
 None
 0.74A 5kc4A-2o1vA:
undetectable		 5kc4A-2o1vA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		3 LYS A 243
LEU A 225
ILE A 257
 None
 0.82A 5kc4A-2olaA:
undetectable		 5kc4A-2olaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		3 LYS A   4
LEU A  49
ILE A 131
 None
 0.77A 5kc4A-2p0lA:
undetectable		 5kc4A-2p0lA:
21.99