SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC0_A_RBFA303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.36A 5kc0A-1ao3A:
0.0		 5kc0A-1ao3A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 105
GLY A 108
ASN A 322
ASN A 386
ASN A 346
 None
 1.36A 5kc0A-1bf2A:
0.0		 5kc0A-1bf2A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.37A 5kc0A-1exbA:
0.0		 5kc0A-1exbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLU A 270
LEU A 264
GLY A 339
MET A 340
PHE A 321
 None
 1.22A 5kc0A-1iugA:
0.0		 5kc0A-1iugA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 LEU T 185
ASP T 189
GLY T 226
ASN T 224
ALA T 170
 None
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.7A)
None
None
 1.41A 5kc0A-1j17T:
undetectable		 5kc0A-1j17T:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LYS A  38
GLY A  15
MET A  73
ASN A 102
LYS A 262
 None
None
None
6PG  A1471 (-2.9A)
6PG  A1471 ( 4.9A)
 1.46A 5kc0A-2iyoA:
1.4		 5kc0A-2iyoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASP A1442
ASN A1273
ALA A1279
ASN A1255
PHE A1222
 MN  A   4 (-2.3A)
MPD  A1695 (-4.4A)
None
None
None
 1.35A 5kc0A-2zxqA:
0.0		 5kc0A-2zxqA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.22A 5kc0A-3jzjA:
0.0		 5kc0A-3jzjA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		7 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.00A 5kc0A-3p5nA:
24.0		 5kc0A-3p5nA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 GLU A 172
LEU A 214
GLY A 239
ASN A  10
ALA A  42
 None
 1.26A 5kc0A-3ta6A:
0.0		 5kc0A-3ta6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		5 GLU A 230
LEU A 199
ALA A 294
ASN A 292
PHE A 291
 None
OGA  A 400 (-4.8A)
None
RUJ  A 401 (-4.1A)
None
 1.43A 5kc0A-4bhiA:
undetectable		 5kc0A-4bhiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		5 GLU A  41
LEU A  21
GLY A  62
ASN A  34
ALA A  26
 None
 1.45A 5kc0A-4fziA:
undetectable		 5kc0A-4fziA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 GLU A   9
LEU A  56
LYS A 103
ASP A  81
ALA A  65
 None
None
None
None
GOL  A 301 (-3.5A)
 1.28A 5kc0A-4lzlA:
undetectable		 5kc0A-4lzlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ASP A 696
GLY A 737
ASN A 739
ALA A 671
LYS A 642
 None
None
2TT  A1201 ( 4.6A)
None
2TT  A1201 ( 4.6A)
 1.45A 5kc0A-4oliA:
undetectable		 5kc0A-4oliA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 GLU A 152
GLY A  82
ALA A  34
ASN A  31
PHE A 234
 SAH  A 301 (-2.2A)
SAH  A 301 (-2.9A)
None
None
MLI  A 302 ( 4.2A)
 1.48A 5kc0A-4pneA:
undetectable		 5kc0A-4pneA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 117
ASP A  70
GLY A  72
ASN A  96
ASN A 143
 None
 1.41A 5kc0A-4u09A:
undetectable		 5kc0A-4u09A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A  37
ASP A  58
GLY A 116
ALA A 120
ASN A 121
 None
 1.28A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A  37
LEU A  72
GLY A 116
ALA A 120
ASN A 121
 None
 1.41A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		12 GLU A  24
LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.60A 5kc0A-5kbwA:
29.3		 5kc0A-5kbwA:
94.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 GLU A 616
ASP A 854
GLY A 853
ALA A 769
PHE A 650
 None
 1.32A 5kc0A-5n94A:
undetectable		 5kc0A-5n94A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 361
GLY A 358
ALA A 434
ASN A 443
PHE A 431
 None
 0.97A 5kc0A-5opjA:
undetectable		 5kc0A-5opjA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 5 GLU A   9
LEU A  56
LYS A 103
ASP A  81
ALA A  65
 None
 1.26A 5kc0A-5vfaA:
undetectable		 5kc0A-5vfaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LYS A 170
ASP A 171
ASN A 224
LYS A 339
PHE A 338
 None
None
PG5  A 501 (-4.1A)
PG5  A 501 ( 4.3A)
None
 1.35A 5kc0A-5w4xA:
undetectable		 5kc0A-5w4xA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 GLU A 582
LEU A 579
GLY A 249
MET A 251
ASN A 250
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.33A 5kc0A-6btmB:
undetectable		 5kc0A-6btmB:
20.35