SIMILAR PATTERNS OF AMINO ACIDS FOR 5KC0_A_RBFA303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.36A 5kc0A-1ao3A:
0.0		 5kc0A-1ao3A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 105
GLY A 108
ASN A 322
ASN A 386
ASN A 346
 None
 1.36A 5kc0A-1bf2A:
0.0		 5kc0A-1bf2A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.37A 5kc0A-1exbA:
0.0		 5kc0A-1exbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLU A 270
LEU A 264
GLY A 339
MET A 340
PHE A 321
 None
 1.22A 5kc0A-1iugA:
0.0		 5kc0A-1iugA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 LEU T 185
ASP T 189
GLY T 226
ASN T 224
ALA T 170
 None
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.7A)
None
None
 1.41A 5kc0A-1j17T:
undetectable		 5kc0A-1j17T:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LYS A  38
GLY A  15
MET A  73
ASN A 102
LYS A 262
 None
None
None
6PG  A1471 (-2.9A)
6PG  A1471 ( 4.9A)
 1.46A 5kc0A-2iyoA:
1.4		 5kc0A-2iyoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASP A1442
ASN A1273
ALA A1279
ASN A1255
PHE A1222
 MN  A   4 (-2.3A)
MPD  A1695 (-4.4A)
None
None
None
 1.35A 5kc0A-2zxqA:
0.0		 5kc0A-2zxqA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.22A 5kc0A-3jzjA:
0.0		 5kc0A-3jzjA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		7 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.00A 5kc0A-3p5nA:
24.0		 5kc0A-3p5nA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 GLU A 172
LEU A 214
GLY A 239
ASN A  10
ALA A  42
 None
 1.26A 5kc0A-3ta6A:
0.0		 5kc0A-3ta6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		5 GLU A 230
LEU A 199
ALA A 294
ASN A 292
PHE A 291
 None
OGA  A 400 (-4.8A)
None
RUJ  A 401 (-4.1A)
None
 1.43A 5kc0A-4bhiA:
undetectable		 5kc0A-4bhiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		5 GLU A  41
LEU A  21
GLY A  62
ASN A  34
ALA A  26
 None
 1.45A 5kc0A-4fziA:
undetectable		 5kc0A-4fziA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 GLU A   9
LEU A  56
LYS A 103
ASP A  81
ALA A  65
 None
None
None
None
GOL  A 301 (-3.5A)
 1.28A 5kc0A-4lzlA:
undetectable		 5kc0A-4lzlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ASP A 696
GLY A 737
ASN A 739
ALA A 671
LYS A 642
 None
None
2TT  A1201 ( 4.6A)
None
2TT  A1201 ( 4.6A)
 1.45A 5kc0A-4oliA:
undetectable		 5kc0A-4oliA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 GLU A 152
GLY A  82
ALA A  34
ASN A  31
PHE A 234
 SAH  A 301 (-2.2A)
SAH  A 301 (-2.9A)
None
None
MLI  A 302 ( 4.2A)
 1.48A 5kc0A-4pneA:
undetectable		 5kc0A-4pneA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 117
ASP A  70
GLY A  72
ASN A  96
ASN A 143
 None
 1.41A 5kc0A-4u09A:
undetectable		 5kc0A-4u09A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A  37
ASP A  58
GLY A 116
ALA A 120
ASN A 121
 None
 1.28A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A  37
LEU A  72
GLY A 116
ALA A 120
ASN A 121
 None
 1.41A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		12 GLU A  24
LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.60A 5kc0A-5kbwA:
29.3		 5kc0A-5kbwA:
94.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 GLU A 616
ASP A 854
GLY A 853
ALA A 769
PHE A 650
 None
 1.32A 5kc0A-5n94A:
undetectable		 5kc0A-5n94A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 361
GLY A 358
ALA A 434
ASN A 443
PHE A 431
 None
 0.97A 5kc0A-5opjA:
undetectable		 5kc0A-5opjA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 5 GLU A   9
LEU A  56
LYS A 103
ASP A  81
ALA A  65
 None
 1.26A 5kc0A-5vfaA:
undetectable		 5kc0A-5vfaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LYS A 170
ASP A 171
ASN A 224
LYS A 339
PHE A 338
 None
None
PG5  A 501 (-4.1A)
PG5  A 501 ( 4.3A)
None
 1.35A 5kc0A-5w4xA:
undetectable		 5kc0A-5w4xA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 GLU A 582
LEU A 579
GLY A 249
MET A 251
ASN A 250
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.33A 5kc0A-6btmB:
undetectable		 5kc0A-6btmB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A  39
LEU A 110
ILE A 207
 None
 0.73A 5kc0A-1amuA:
0.0		 5kc0A-1amuA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		3 LYS A   2
LEU A  20
ILE A  29
 None
 0.77A 5kc0A-1aqlA:
0.0		 5kc0A-1aqlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		3 LYS A  77
LEU A 220
ILE A 130
 None
PC1  A 777 ( 4.7A)
None
 0.72A 5kc0A-1bp1A:
undetectable		 5kc0A-1bp1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 LYS A 495
LEU A 555
ILE A 539
 None
 0.74A 5kc0A-1c4kA:
undetectable		 5kc0A-1c4kA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF00729
(Viral_coat) 		3 LYS A 261
LEU A 114
ILE A 258
 None
 0.67A 5kc0A-1c8nA:
undetectable		 5kc0A-1c8nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		3 LYS A 153
LEU A  79
ILE A 173
 None
 0.78A 5kc0A-1ceeA:
0.4		 5kc0A-1ceeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		3 LYS A 841
LEU A 826
ILE A 770
 None
 0.68A 5kc0A-1d5fA:
1.3		 5kc0A-1d5fA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 LYS A 254
LEU A 218
ILE A 248
 None
 0.78A 5kc0A-1e5wA:
0.3		 5kc0A-1e5wA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS A  21
LEU A 320
ILE A   9
 None
 0.74A 5kc0A-1ehiA:
0.0		 5kc0A-1ehiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 LYS A 341
LEU A 505
ILE A 338
 None
 0.76A 5kc0A-1ewkA:
0.0		 5kc0A-1ewkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LYS O   2
LEU O 322
ILE O   5
 None
 0.56A 5kc0A-1gaeO:
0.0		 5kc0A-1gaeO:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		3 LYS A 138
LEU A  36
ILE A   3
 None
 0.76A 5kc0A-1h4oA:
undetectable		 5kc0A-1h4oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		3 LYS A 143
LEU A 146
ILE A 195
 EDO  A 282 (-2.8A)
None
None
 0.68A 5kc0A-1hnoA:
undetectable		 5kc0A-1hnoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huq RAB5C

(Mus musculus) 		PF00071
(Ras) 		3 LYS A 181
LEU A  24
ILE A 174
 None
 0.77A 5kc0A-1huqA:
undetectable		 5kc0A-1huqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihj INAD

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 LYS A  51
LEU A  65
ILE A  71
 None
 0.73A 5kc0A-1ihjA:
undetectable		 5kc0A-1ihjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS A 115
LEU A 119
ILE A  48
 None
 0.66A 5kc0A-1jpeA:
undetectable		 5kc0A-1jpeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzd THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF11412
(DsbC) 		3 LYS C 115
LEU C 119
ILE C  48
 None
 0.66A 5kc0A-1jzdC:
undetectable		 5kc0A-1jzdC:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		3 LYS A  30
LEU A  34
ILE A   6
 None
 0.77A 5kc0A-1l8tA:
undetectable		 5kc0A-1l8tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 LYS A 116
LEU A 376
ILE A 113
 None
 0.56A 5kc0A-1lwdA:
3.2		 5kc0A-1lwdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LYS A 298
LEU A 412
ILE A 295
 None
 0.60A 5kc0A-1lxtA:
undetectable		 5kc0A-1lxtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV

(Thermotoga
maritima) 		PF00227
(Proteasome) 		3 LYS A  33
LEU A  43
ILE A 168
 None
 0.68A 5kc0A-1m4yA:
undetectable		 5kc0A-1m4yA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhd SMAD3

(Homo sapiens) 		PF03165
(MH1) 		3 LYS A  13
LEU A  38
ILE A  55
 None
 0.77A 5kc0A-1mhdA:
undetectable		 5kc0A-1mhdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 LYS A  13
LEU A  27
ILE A  67
 MAN  A 653 ( 4.3A)
None
None
 0.66A 5kc0A-1moxA:
undetectable		 5kc0A-1moxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS E 160
LEU E 132
ILE E 155
 None
 0.71A 5kc0A-1nfdE:
undetectable		 5kc0A-1nfdE:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkp MAX PROTEIN
MYC PROTO-ONCOGENE
PROTEIN

(Homo sapiens) 		PF00010
(HLH)
PF02344
(Myc-LZ) 		3 LYS A 945
LEU B 243
ILE B 218
 None
 0.77A 5kc0A-1nkpA:
undetectable		 5kc0A-1nkpA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 LYS A 169
LEU A 119
ILE A 166
 None
 0.77A 5kc0A-1nntA:
undetectable		 5kc0A-1nntA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF13302
(Acetyltransf_3) 		3 LYS A 116
LEU A 125
ILE A  68
 None
 0.76A 5kc0A-1nslA:
undetectable		 5kc0A-1nslA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		3 LYS A  10
LEU A  18
ILE A 142
 None
 0.72A 5kc0A-1o20A:
undetectable		 5kc0A-1o20A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 LYS A 124
LEU A 165
ILE A  82
 None
 0.66A 5kc0A-1ohtA:
undetectable		 5kc0A-1ohtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		3 LYS A 177
LEU A 122
ILE A 127
 None
 0.77A 5kc0A-1oroA:
0.9		 5kc0A-1oroA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1owx LUPUS LA PROTEIN

(Homo sapiens) 		PF08777
(RRM_3) 		3 LYS A 276
LEU A 234
ILE A 262
 None
 0.64A 5kc0A-1owxA:
undetectable		 5kc0A-1owxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prs DEVELOPMENT-SPECIFIC
PROTEIN S

(Myxococcus
xanthus) 		PF00030
(Crystall) 		3 LYS A 132
LEU A 108
ILE A 128
 None
 0.72A 5kc0A-1prsA:
undetectable		 5kc0A-1prsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		3 LYS A 271
LEU A 221
ILE A 263
 None
 0.77A 5kc0A-1pujA:
undetectable		 5kc0A-1pujA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 LYS A 440
LEU A 448
ILE A 376
 None
 0.62A 5kc0A-1qoxA:
undetectable		 5kc0A-1qoxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1s GRB2-RELATED ADAPTOR
PROTEIN 2

(Mus musculus) 		PF00017
(SH2) 		3 LYS A 129
LEU A 119
ILE A  84
 SO4  A3486 ( 3.8A)
None
None
 0.78A 5kc0A-1r1sA:
undetectable		 5kc0A-1r1sA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LYS A 317
LEU A 342
ILE A 311
 None
 0.71A 5kc0A-1r8wA:
undetectable		 5kc0A-1r8wA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A  16
LEU A 336
ILE A 316
 None
 0.68A 5kc0A-1rjwA:
undetectable		 5kc0A-1rjwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 LYS A 167
LEU A 207
ILE A 151
 None
 0.76A 5kc0A-1ry2A:
undetectable		 5kc0A-1ry2A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		3 LYS A   3
LEU A 357
ILE A  33
 None
 0.60A 5kc0A-1s6rA:
undetectable		 5kc0A-1s6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 LYS A  64
LEU A  16
ILE A  40
 None
 0.56A 5kc0A-1sxlA:
undetectable		 5kc0A-1sxlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 LYS A 173
LEU A 132
ILE A  18
 None
 0.76A 5kc0A-1tcsA:
undetectable		 5kc0A-1tcsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0j DNA REPLICATION
PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF01057
(Parvo_NS1) 		3 LYS A 372
LEU A 284
ILE A 417
 None
 0.65A 5kc0A-1u0jA:
undetectable		 5kc0A-1u0jA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 LYS A 319
LEU A 327
ILE A 312
 None
 0.74A 5kc0A-1u0uA:
undetectable		 5kc0A-1u0uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A  80
LEU A  24
ILE A  74
 None
 0.69A 5kc0A-1u3iA:
2.6		 5kc0A-1u3iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgk RIKEN CDNA
2900073H19 PROTEIN

(Mus musculus) 		PF09138
(Urm1) 		3 LYS A  53
LEU A  36
ILE A  99
 None
 0.72A 5kc0A-1wgkA:
undetectable		 5kc0A-1wgkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk4 TTK003001606

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		3 LYS A 135
LEU A 143
ILE A  94
 None
None
MES  A 201 (-4.2A)
 0.73A 5kc0A-1wk4A:
undetectable		 5kc0A-1wk4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A1148
LEU A1184
ILE A1135
 None
 0.77A 5kc0A-1wueA:
undetectable		 5kc0A-1wueA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvn POLY(RC)-BINDING
PROTEIN 1

(Homo sapiens) 		PF00013
(KH_1) 		3 LYS A  40
LEU A  10
ILE A  20
 None
 0.70A 5kc0A-1wvnA:
undetectable		 5kc0A-1wvnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		3 LYS A  94
LEU A 106
ILE A  69
 None
 0.73A 5kc0A-1xeaA:
undetectable		 5kc0A-1xeaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 LYS A  32
LEU A   6
ILE A 130
 None
 0.60A 5kc0A-1xntA:
undetectable		 5kc0A-1xntA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		3 LYS A  40
LEU A  44
ILE A  61
 None
 0.67A 5kc0A-1y51A:
undetectable		 5kc0A-1y51A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		3 LYS A 182
LEU A 171
ILE A 187
 None
 0.75A 5kc0A-1y8pA:
1.9		 5kc0A-1y8pA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 LYS A  11
LEU A  40
ILE A   5
 SAH  A 401 (-4.8A)
None
None
 0.78A 5kc0A-1yfjA:
undetectable		 5kc0A-1yfjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		3 LYS A 205
LEU A  52
ILE A  44
 None
 0.78A 5kc0A-1yzwA:
undetectable		 5kc0A-1yzwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		3 LYS A 174
LEU A 167
ILE A 214
 None
 0.69A 5kc0A-2abqA:
undetectable		 5kc0A-2abqA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 LYS A 314
LEU A 322
ILE A 301
 None
 0.33A 5kc0A-2aeuA:
undetectable		 5kc0A-2aeuA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		3 LYS A   7
LEU A 139
ILE A 148
 None
 0.71A 5kc0A-2aznA:
undetectable		 5kc0A-2aznA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0a HYPOTHETICAL PROTEIN
MJ0783

(Methanocaldococcus
jannaschii) 		PF04199
(Cyclase) 		3 LYS A 121
LEU A 140
ILE A  45
 None
 0.69A 5kc0A-2b0aA:
undetectable		 5kc0A-2b0aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1154
LEU A1087
ILE A1148
 None
 0.71A 5kc0A-2b39A:
undetectable		 5kc0A-2b39A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		3 LYS A  50
LEU A  58
ILE A  36
 None
 0.75A 5kc0A-2bb6A:
2.1		 5kc0A-2bb6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		3 LYS A 630
LEU A 510
ILE A 589
 None
 0.70A 5kc0A-2bmbA:
undetectable		 5kc0A-2bmbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 LYS A  36
LEU A  66
ILE A  43
 None
 0.74A 5kc0A-2c5sA:
undetectable		 5kc0A-2c5sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 LYS A 197
LEU A 178
ILE A 190
 None
 0.75A 5kc0A-2c5uA:
undetectable		 5kc0A-2c5uA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		3 LYS A  29
LEU A 139
ILE A  69
 None
 0.55A 5kc0A-2csuA:
1.5		 5kc0A-2csuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A 186
LEU A 206
ILE A 173
 None
 0.78A 5kc0A-2cxeA:
undetectable		 5kc0A-2cxeA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9c SIGNAL-REGULATORY
PROTEIN BETA-1

(Homo sapiens) 		PF07686
(V-set) 		3 LYS A 101
LEU A   9
ILE A  41
 None
 0.74A 5kc0A-2d9cA:
undetectable		 5kc0A-2d9cA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		3 LYS A 183
LEU A  69
ILE A 166
 None
 0.73A 5kc0A-2e1tA:
undetectable		 5kc0A-2e1tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		3 LYS A  11
LEU A 235
ILE A 248
 None
 0.76A 5kc0A-2ebnA:
undetectable		 5kc0A-2ebnA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke UBIQUITIN-LIKE
PROTEIN SMT3

(Saccharomyces
cerevisiae) 		PF11976
(Rad60-SLD) 		3 LYS C1027
LEU C1045
ILE C1024
 None
 0.76A 5kc0A-2ekeC:
undetectable		 5kc0A-2ekeC:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 LYS A   9
LEU A 450
ILE A  13
 None
 0.72A 5kc0A-2fvmA:
undetectable		 5kc0A-2fvmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2q GLUTAREDOXIN-2

(Vaccinia virus) 		PF05768
(DUF836) 		3 LYS A  27
LEU A 107
ILE A   7
 None
 0.77A 5kc0A-2g2qA:
undetectable		 5kc0A-2g2qA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 280
LEU A 186
ILE A 273
 None
 0.75A 5kc0A-2g6zA:
undetectable		 5kc0A-2g6zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 LYS A   3
LEU A 359
ILE A 328
 None
 0.77A 5kc0A-2g8yA:
undetectable		 5kc0A-2g8yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 LYS A 376
LEU A 360
ILE A 414
 None
 0.65A 5kc0A-2gepA:
undetectable		 5kc0A-2gepA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A  68
LEU A  59
ILE A 155
 None
 0.73A 5kc0A-2hdiA:
undetectable		 5kc0A-2hdiA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF03480
(DctP) 		3 LYS A  52
LEU A 256
ILE A  59
 None
 0.71A 5kc0A-2hpgA:
0.9		 5kc0A-2hpgA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20

(Saccharomyces
cerevisiae) 		PF08612
(Med20)
PF09637
(Med18) 		3 LYS A 111
LEU B 207
ILE A 104
 None
 0.67A 5kc0A-2hzsA:
undetectable		 5kc0A-2hzsA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 391
LEU A 403
ILE A 462
 SEP  A 660 ( 3.7A)
None
None
 0.76A 5kc0A-2i0eA:
undetectable		 5kc0A-2i0eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 LYS A 254
LEU A 218
ILE A 248
 None
 0.76A 5kc0A-2i1jA:
undetectable		 5kc0A-2i1jA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 LYS A  36
LEU A 174
ILE A  28
 None
 0.60A 5kc0A-2i7tA:
undetectable		 5kc0A-2i7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Rattus
norvegicus) 		PF05881
(CNPase) 		3 LYS A 103
LEU A  70
ILE A 106
 None
 0.66A 5kc0A-2ilxA:
undetectable		 5kc0A-2ilxA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		3 LYS A  13
LEU A  54
ILE A  27
 None
 0.70A 5kc0A-2iu5A:
2.9		 5kc0A-2iu5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		3 LYS A 116
LEU A  28
ILE A 100
 None
 0.67A 5kc0A-2ix2A:
undetectable		 5kc0A-2ix2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 LYS A 176
LEU A 168
ILE A 117
 None
 0.77A 5kc0A-2iy8A:
undetectable		 5kc0A-2iy8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 LYS A 224
LEU A 218
ILE A 110
 None
 0.66A 5kc0A-2iy8A:
undetectable		 5kc0A-2iy8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40

(Saccharomyces
cerevisiae) 		PF15985
(KH_6) 		3 LYS A 197
LEU A 175
ILE A 194
 None
 0.75A 5kc0A-2ja9A:
undetectable		 5kc0A-2ja9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		3 LYS A  32
LEU A 142
ILE A  55
 None
 0.78A 5kc0A-2k7hA:
undetectable		 5kc0A-2k7hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd0 LRR REPEATS AND
UBIQUITIN-LIKE
DOMAIN-CONTAINING
PROTEIN AT2G30105

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		3 LYS A  77
LEU A  37
ILE A  13
 None
 0.72A 5kc0A-2kd0A:
undetectable		 5kc0A-2kd0A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Vibrio
parahaemolyticus) 		PF01035
(DNA_binding_1) 		3 LYS A  41
LEU A  52
ILE A  26
 None
 0.72A 5kc0A-2kifA:
undetectable		 5kc0A-2kifA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		3 LYS A 417
LEU A 345
ILE A 363
 None
 0.74A 5kc0A-2lf8A:
undetectable		 5kc0A-2lf8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		3 LYS A  15
LEU A  70
ILE A 149
 None
 0.77A 5kc0A-2lfcA:
undetectable		 5kc0A-2lfcA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2li6 SWI/SNF
CHROMATIN-REMODELING
COMPLEX SUBUNIT SWI1

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		3 LYS A  25
LEU A  54
ILE A  95
 None
 0.56A 5kc0A-2li6A:
undetectable		 5kc0A-2li6A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4e PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio
vulnificus) 		PF16691
(DUF5062) 		3 LYS A  68
LEU A  48
ILE A  75
 None
 0.69A 5kc0A-2m4eA:
undetectable		 5kc0A-2m4eA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4n PROTEIN AFD-1,
ISOFORM A

(Caenorhabditis
elegans) 		PF00788
(RA) 		3 LYS A   1
LEU A   7
ILE A  27
 None
 0.69A 5kc0A-2m4nA:
undetectable		 5kc0A-2m4nA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlb REDESIGNED UBIQUITIN

(synthetic
construct) 		PF00240
(ubiquitin) 		3 LYS A  43
LEU A  27
ILE A  68
 None
 0.71A 5kc0A-2mlbA:
undetectable		 5kc0A-2mlbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8l INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1

(Gallus gallus) 		PF00013
(KH_1) 		3 LYS A  40
LEU A  48
ILE A  37
 C  B   2 ( 4.8A)
None
None
 0.71A 5kc0A-2n8lA:
undetectable		 5kc0A-2n8lA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 LYS A 419
LEU A 422
ILE A 445
 None
 0.69A 5kc0A-2nrrA:
undetectable		 5kc0A-2nrrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 LYS A  29
LEU A  22
ILE A  66
 None
 0.63A 5kc0A-2nygA:
undetectable		 5kc0A-2nygA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		3 LYS A 336
LEU A 120
ILE A  50
 None
 0.61A 5kc0A-2nzxA:
undetectable		 5kc0A-2nzxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Archaeoglobus
fulgidus) 		PF00005
(ABC_tran) 		3 LYS A   4
LEU A 181
ILE A 205
 None
 0.77A 5kc0A-2onkA:
undetectable		 5kc0A-2onkA:
23.11