SIMILAR PATTERNS OF AMINO ACIDS FOR 5KBW_B_RBFB201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE


(Gadus morhua)
PF00171
(Aldedh)
5 GLY A 265
ALA A 164
ASN A 166
VAL A 296
LYS A 175
None
1.37A 5kbwB-1a4sA:
undetectable
5kbwB-1a4sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)


(Ochrobactrum
anthropi)
PF03576
(Peptidase_S58)
5 GLU A 144
ASP A 290
ASN A 218
ALA A 339
VAL A 332
None
1.35A 5kbwB-1b65A:
0.0
5kbwB-1b65A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)


(Bacillus
megaterium)
PF00258
(Flavodoxin_1)
5 LEU F 516
ASP F 586
ALA F 497
VAL F 529
TYR F 564
None
1.17A 5kbwB-1bvyF:
undetectable
5kbwB-1bvyF:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli)
PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3)
5 GLU A  87
ASP A 172
ALA A 153
VAL A 194
TYR A 197
None
1.31A 5kbwB-1g7oA:
undetectable
5kbwB-1g7oA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqa CYTOCHROME C'

(Rhodobacter
sphaeroides)
PF01322
(Cytochrom_C_2)
5 GLU A  31
LYS A  29
GLY A  22
ALA A 101
VAL A 115
None
1.32A 5kbwB-1gqaA:
undetectable
5kbwB-1gqaA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 GLU A 185
GLY A  92
ALA A  16
ASN A 141
ASN A  17
None
ADP  A 400 (-3.7A)
ILE  A 500 ( 4.0A)
ILE  A 500 (-4.2A)
ILE  A 500 (-2.8A)
1.21A 5kbwB-1h74A:
0.2
5kbwB-1h74A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7h HYPOTHETICAL PROTEIN
HI0719


(Haemophilus
influenzae)
PF01042
(Ribonuc_L-PSP)
5 LEU A 121
ASN A  57
ALA A  49
VAL A  88
TYR A  92
None
1.35A 5kbwB-1j7hA:
0.8
5kbwB-1j7hA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Pectobacterium
carotovorum)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 LEU A 286
ASP A 295
GLY A 294
ALA A 334
VAL A 302
None
1.33A 5kbwB-1khdA:
0.0
5kbwB-1khdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacillus
subtilis)
PF08282
(Hydrolase_3)
5 GLU A 132
GLY A  10
ALA A 278
ASN A  23
VAL A  19
None
CA  A 903 ( 4.4A)
None
None
None
1.25A 5kbwB-1nrwA:
undetectable
5kbwB-1nrwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 ASP A 131
GLY A 121
ALA A 109
VAL A  98
TYR A  97
None
1.36A 5kbwB-1p2fA:
0.0
5kbwB-1p2fA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4t OUTER MEMBRANE
PROTEIN NSPA


(Neisseria
meningitidis)
PF02462
(Opacity)
5 LEU A  61
GLY A 145
ALA A  24
VAL A 142
ASN A  51
None
None
CXE  A 500 ( 4.1A)
CXE  A 500 ( 4.5A)
None
1.24A 5kbwB-1p4tA:
undetectable
5kbwB-1p4tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT


(Deinococcus
radiodurans)
PF03328
(HpcH_HpaI)
5 LEU A 128
GLY A 105
ASN A 136
ALA A 181
VAL A 146
None
1.20A 5kbwB-1sgjA:
undetectable
5kbwB-1sgjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq TENASCIN-R

(Rattus
norvegicus)
PF00041
(fn3)
5 GLY A 163
ASN A 181
ALA A 178
VAL A 126
TYR A 128
None
1.28A 5kbwB-1tdqA:
undetectable
5kbwB-1tdqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
5 LEU A 324
ASP A 295
GLY A 299
ASN A 345
TYR A 318
None
1.36A 5kbwB-1xogA:
undetectable
5kbwB-1xogA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yck PEPTIDOGLYCAN
RECOGNITION PROTEIN


(Homo sapiens)
PF01510
(Amidase_2)
5 LEU A 162
ASP A 151
GLY A 148
ALA A 127
TYR A 172
None
1.18A 5kbwB-1yckA:
undetectable
5kbwB-1yckA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
5 LEU A 232
GLY A 303
ASN A 180
ALA A 268
TYR A 289
None
1.27A 5kbwB-1ygaA:
undetectable
5kbwB-1ygaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE


(Escherichia
coli)
PF04996
(AstB)
5 GLY A 175
ASN A 178
ALA A 364
VAL A 108
ASN A 306
None
None
None
None
SUG  A1001 ( 4.1A)
1.33A 5kbwB-1yniA:
undetectable
5kbwB-1yniA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd)
5 LEU A 591
GLY A 661
ASN A 541
ALA A 626
TYR A 647
None
None
None
None
GAL  A 700 (-4.1A)
1.19A 5kbwB-1z45A:
undetectable
5kbwB-1z45A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN


(Escherichia
coli)
no annotation 5 LEU A  45
ASP A  68
GLY A  69
ALA A  73
VAL A  78
None
1.40A 5kbwB-2aukA:
undetectable
5kbwB-2aukA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus)
PF00405
(Transferrin)
5 ASP A 572
GLY A 573
ASN A 444
ALA A 437
LYS A 451
None
1.39A 5kbwB-2d3iA:
undetectable
5kbwB-2d3iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE


(Bacillus sp.
707)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
5 GLY A  96
ASN A  94
ALA A  88
VAL A  42
ASN A  28
None
1.40A 5kbwB-2d3lA:
undetectable
5kbwB-2d3lA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
5 LEU A 183
ASP A 198
GLY A 195
ASN A 193
ASN A 271
None
1.39A 5kbwB-2fj0A:
undetectable
5kbwB-2fj0A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi)
PF01353
(GFP)
5 LEU A 210
LYS A 209
ASP A  28
GLY A  27
ALA A  60
CR8  A  63 ( 3.8A)
None
None
None
None
1.40A 5kbwB-2gw3A:
undetectable
5kbwB-2gw3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis)
PF01979
(Amidohydro_1)
5 GLU A 321
LYS A  74
GLY A 333
ALA A  83
VAL A  64
None
1.21A 5kbwB-2gwnA:
undetectable
5kbwB-2gwnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hae MALATE
OXIDOREDUCTASE


(Thermotoga
maritima)
PF00390
(malic)
PF03949
(Malic_M)
5 GLU A 287
GLY A 304
ASN A 283
ASN A 314
VAL A 162
None
1.38A 5kbwB-2haeA:
undetectable
5kbwB-2haeA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0r CALPAIN-9

(Homo sapiens)
PF00648
(Peptidase_C2)
5 LEU A 229
GLY A 202
ASN A 335
ALA A 112
ASN A 109
None
1.40A 5kbwB-2p0rA:
undetectable
5kbwB-2p0rA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE


(Porphyromonas
gingivalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 ASP A 118
ASN A 115
ALA A 206
VAL A 287
TYR A 286
None
1.28A 5kbwB-2qytA:
1.5
5kbwB-2qytA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE


(Porphyromonas
gingivalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 GLY A 116
ASN A 115
ALA A 206
VAL A 287
TYR A 286
None
1.30A 5kbwB-2qytA:
1.5
5kbwB-2qytA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE


(Photobacterium
sp. JT-ISH-224)
PF11477
(PM0188)
5 ASP A 231
GLY A 233
ALA A 448
VAL A 485
TYR A 237
None
GOL  A3004 (-3.3A)
None
None
None
1.35A 5kbwB-2z4tA:
undetectable
5kbwB-2z4tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus)
PF00150
(Cellulase)
5 GLU A  12
GLY A 102
ASN A  63
VAL A  95
TYR A  99
None
1.22A 5kbwB-3ayrA:
undetectable
5kbwB-3ayrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1


(Homo sapiens)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
5 ASP A 337
GLY A 417
VAL A 377
TYR A 420
ASN A 219
None
1.39A 5kbwB-3ctzA:
undetectable
5kbwB-3ctzA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Homo sapiens)
PF00305
(Lipoxygenase)
5 GLY A 235
ASN A 237
ALA A 557
ASN A 556
TYR A 230
None
1.40A 5kbwB-3d3lA:
1.4
5kbwB-3d3lA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
5 GLU A  29
ASP A 241
GLY A 284
ALA A  37
ASN A  38
None
1.40A 5kbwB-3ewmA:
undetectable
5kbwB-3ewmA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Methylobacillus
flagellatus)
PF13460
(NAD_binding_10)
5 LEU A  94
ASN A  89
ALA A   7
VAL A 102
TYR A 145
None
1.30A 5kbwB-3gpiA:
undetectable
5kbwB-3gpiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii)
PF00294
(PfkB)
5 LEU A  67
ASP A 287
GLY A 284
ALA A 276
ASN A 299
None
1.25A 5kbwB-3hj6A:
undetectable
5kbwB-3hj6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii)
PF00294
(PfkB)
5 LEU A  67
GLY A 284
ALA A 276
ASN A 299
ASN A  63
None
1.38A 5kbwB-3hj6A:
undetectable
5kbwB-3hj6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE


(Bacillus
anthracis)
PF00561
(Abhydrolase_1)
5 LYS A 361
ASN A 367
ALA A 147
VAL A 307
TYR A 336
None
1.28A 5kbwB-3i1iA:
undetectable
5kbwB-3i1iA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410


(Mycobacterium
tuberculosis)
PF07228
(SpoIIE)
PF13581
(HATPase_c_2)
5 LEU A 304
ASP A 211
GLY A 210
ALA A 229
VAL A 222
None
MN  A   2 ( 2.5A)
None
None
None
1.29A 5kbwB-3ke6A:
undetectable
5kbwB-3ke6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzh PROBABLE SUGAR
KINASE


(Clostridium
perfringens)
PF00294
(PfkB)
5 GLU A 315
ASP A 229
GLY A 230
ASN A 285
VAL A 247
None
1.36A 5kbwB-3kzhA:
undetectable
5kbwB-3kzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN


(Paraburkholderia
xenovorans)
PF13458
(Peripla_BP_6)
6 LEU A 314
LYS A 315
ASP A 339
ALA A  96
VAL A  51
TYR A 307
None
1.31A 5kbwB-3n0wA:
undetectable
5kbwB-3n0wA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne7 ACETYLTRANSFERASE

(Thermoplasma
acidophilum)
PF00583
(Acetyltransf_1)
5 GLU A 112
LEU A 125
GLY A 142
ASN A 141
VAL A 145
None
BME  A 162 ( 3.9A)
None
GOL  A 165 (-3.0A)
None
1.20A 5kbwB-3ne7A:
undetectable
5kbwB-3ne7A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
5 LEU A  14
ASP A 223
GLY A 218
ALA A 260
ASN A  25
None
MG  A 278 ( 4.3A)
None
None
None
1.25A 5kbwB-3niwA:
undetectable
5kbwB-3niwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula)
PF05721
(PhyH)
5 GLU A  43
LEU A  37
ALA A 101
ASN A 100
VAL A  76
None
None
FMT  A 750 ( 4.0A)
None
None
1.31A 5kbwB-3nnmA:
undetectable
5kbwB-3nnmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5c CYTOCHROME C551
PEROXIDASE


(Shewanella
oneidensis)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
5 GLU A  36
LEU A  42
LYS A  39
ALA A 143
VAL A 154
None
0.96A 5kbwB-3o5cA:
undetectable
5kbwB-3o5cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oao UNCHARACTERIZED
PROTEIN FROM DUF2059
FAMILY


(Pseudomonas
aeruginosa)
PF09832
(DUF2059)
5 ASP A  95
GLY A  99
ALA A  51
VAL A  56
TYR A  59
None
None
PO4  A   2 ( 4.2A)
None
None
1.28A 5kbwB-3oaoA:
undetectable
5kbwB-3oaoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
5 GLU A 382
GLY B 471
ALA B 475
VAL B 245
ASN B 720
None
1.21A 5kbwB-3opyA:
undetectable
5kbwB-3opyA:
12.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN


(Staphylococcus
aureus)
PF12822
(ECF_trnsprt)
5 ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
0.65A 5kbwB-3p5nA:
24.1
5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN


(Staphylococcus
aureus)
PF12822
(ECF_trnsprt)
5 ASP A  81
GLY A  84
ASN A  88
ASN A 131
LYS A 167
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.2A)
0.73A 5kbwB-3p5nA:
24.1
5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN


(Staphylococcus
aureus)
PF12822
(ECF_trnsprt)
5 LEU A  42
GLY A  84
ASN A  88
ASN A 131
ASN A 164
RBF  A 190 (-4.6A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
0.49A 5kbwB-3p5nA:
24.1
5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN


(Staphylococcus
aureus)
PF12822
(ECF_trnsprt)
5 LEU A  42
GLY A  84
ASN A  88
ASN A 131
LYS A 167
RBF  A 190 (-4.6A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.2A)
0.56A 5kbwB-3p5nA:
24.1
5kbwB-3p5nA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
5 LEU B 567
ASP B 553
GLY B 552
ALA B 803
VAL B 789
None
1.41A 5kbwB-3prxB:
undetectable
5kbwB-3prxB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF04536
(TPM_phosphatase)
5 LEU A 122
GLY A 166
ASN A 131
ALA A 219
VAL A 189
None
1.26A 5kbwB-3pw9A:
1.6
5kbwB-3pw9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
5 ASP A 274
ALA A 255
ASN A 194
VAL A 196
TYR A 198
None
1.44A 5kbwB-3r5tA:
undetectable
5kbwB-3r5tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 LEU A 123
ASP A 147
GLY A 144
ALA A 136
VAL A 320
None
1.20A 5kbwB-3ramA:
undetectable
5kbwB-3ramA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Sus scrofa)
PF00305
(Lipoxygenase)
5 GLY A 236
ASN A 238
ALA A 558
ASN A 557
TYR A 231
None
1.39A 5kbwB-3rdeA:
1.8
5kbwB-3rdeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Sus scrofa)
PF00305
(Lipoxygenase)
5 GLY A 236
ASN A 238
ALA A 558
ASN A 557
VAL A 219
None
1.38A 5kbwB-3rdeA:
1.8
5kbwB-3rdeA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00121
(TIM)
5 GLU A 172
LEU A 214
GLY A 239
ASN A  10
ALA A  42
None
1.27A 5kbwB-3ta6A:
undetectable
5kbwB-3ta6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucn CARBONIC ANHYDRASE

(Coccomyxa sp.
PA)
PF00484
(Pro_CA)
5 LEU A  74
GLY A 112
ASN A 157
VAL A 133
ASN A  73
None
1.24A 5kbwB-3ucnA:
undetectable
5kbwB-3ucnA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE


(Homo sapiens)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 GLY A 239
ASN A 241
ALA A 567
ASN A 566
TYR A 234
None
1.36A 5kbwB-3v98A:
1.2
5kbwB-3v98A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 ASP A 269
GLY A 511
ALA A 164
ASN A 284
VAL A 281
MG  A1768 ( 3.9A)
None
None
None
None
1.39A 5kbwB-4a01A:
1.9
5kbwB-4a01A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB


(Escherichia
coli)
PF13416
(SBP_bac_8)
5 GLU A 176
ASN A 191
VAL A 101
TYR A 105
ASN A 279
None
1.12A 5kbwB-4aq4A:
undetectable
5kbwB-4aq4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE


(Methanocaldococcus
jannaschii)
PF00464
(SHMT)
5 LYS A 226
ASP A 196
GLY A 197
ALA A 205
VAL A 235
None
1.38A 5kbwB-4bhdA:
undetectable
5kbwB-4bhdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnd ALPHA-PHOSPHOGLUCOMU
TASE


(Lactococcus
lactis)
PF03332
(PMM)
5 LEU B  13
ASP B 220
GLY B 211
ASN B  11
ALA B 240
None
None
None
None
GOL  B1253 ( 2.6A)
1.36A 5kbwB-4bndB:
undetectable
5kbwB-4bndB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnd ALPHA-PHOSPHOGLUCOMU
TASE


(Lactococcus
lactis)
PF03332
(PMM)
5 LEU B  13
ASP B 220
GLY B 211
ASN B  11
TYR B 209
None
1.32A 5kbwB-4bndB:
undetectable
5kbwB-4bndB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN


(Bacillus
licheniformis)
PF01839
(FG-GAP)
5 ASP A 551
GLY A 572
ASN A 377
ALA A 405
VAL A 337
None
None
CA  A 608 (-2.9A)
None
None
1.42A 5kbwB-4cagA:
undetectable
5kbwB-4cagA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris)
PF01979
(Amidohydro_1)
5 GLU A 373
ASP A 367
GLY A 366
ALA A 311
ASN A 309
None
1.16A 5kbwB-4dzhA:
undetectable
5kbwB-4dzhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE


(Parabacteroides
distasonis)
PF13859
(BNR_3)
PF14873
(BNR_assoc_N)
5 LEU A 440
GLY A 416
ALA A 447
ASN A 468
ASN A 409
None
1.23A 5kbwB-4fj6A:
undetectable
5kbwB-4fj6A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN


(Streptomyces
himastatinicus)
PF00067
(p450)
5 LEU A 188
GLY A 194
ALA A 230
VAL A 143
ASN A 231
None
1.12A 5kbwB-4ggvA:
undetectable
5kbwB-4ggvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7a CRISPR-ASSOCIATED
PROTEIN CSE2


(Thermus
thermophilus)
PF09485
(CRISPR_Cse2)
5 LEU A 131
ASP A  75
GLY A 125
ALA A  83
VAL A 119
None
1.26A 5kbwB-4h7aA:
undetectable
5kbwB-4h7aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
5 GLU A 219
GLY A 344
ASN A 244
VAL A 401
ASN A 283
None
1.39A 5kbwB-4jklA:
undetectable
5kbwB-4jklA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 LEU A 345
LYS A 334
GLY A  98
ALA A 414
VAL A 391
None
1.28A 5kbwB-4oyaA:
undetectable
5kbwB-4oyaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae)
PF07859
(Abhydrolase_3)
5 LEU A 175
GLY A 153
ASN A 155
ALA A 161
TYR A  76
None
1.08A 5kbwB-4p9nA:
1.4
5kbwB-4p9nA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN


(Bacteroides
caccae)
PF13088
(BNR_2)
PF14873
(BNR_assoc_N)
5 LEU A 460
GLY A 436
ALA A 467
ASN A 488
ASN A 429
None
1.26A 5kbwB-4q6kA:
undetectable
5kbwB-4q6kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE


(Psychrobacter
sp. B6)
PF00155
(Aminotran_1_2)
5 LEU A  81
ASN A 247
VAL A 311
TYR A 312
ASN A 242
NO3  A 404 (-3.8A)
None
None
None
None
1.38A 5kbwB-4rkcA:
undetectable
5kbwB-4rkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY


(Thermococcus
kodakarensis)
no annotation 5 LEU A  77
ASP A 219
GLY A 216
VAL A  10
LYS A  16
INS  A 301 ( 4.8A)
INS  A 301 (-2.7A)
ACP  A 302 (-3.9A)
INS  A 301 ( 4.8A)
None
1.33A 5kbwB-4xf7A:
undetectable
5kbwB-4xf7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV)
5 GLU A 248
LEU A 120
GLY A 228
VAL A 231
ASN A 331
None
1.38A 5kbwB-4z11A:
undetectable
5kbwB-4z11A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8i PEPTIDOGLYCAN
RECOGNITION PROTEIN
3


(Branchiostoma
belcheri)
PF01510
(Amidase_2)
5 LEU A 215
ASP A 204
GLY A 201
ALA A 180
TYR A 225
None
1.15A 5kbwB-4z8iA:
undetectable
5kbwB-4z8iA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE


(Caulobacter
vibrioides)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 LEU A 127
GLY A 130
ALA A 107
VAL A  79
TYR A  78
None
1.26A 5kbwB-5a05A:
undetectable
5kbwB-5a05A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3i CYTOCHROME C PRIME

(Hydrogenophilus
thermoluteolus)
PF01322
(Cytochrom_C_2)
5 LEU A 101
ASP A 109
GLY A 108
ALA A  45
VAL A  30
None
1.40A 5kbwB-5b3iA:
2.6
5kbwB-5b3iA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 ASP A 170
GLY A 459
ALA A  39
VAL A 769
ASN A 591
MO  A1002 ( 2.6A)
BSY  A1013 ( 3.0A)
None
MGD  A1003 ( 4.1A)
None
1.19A 5kbwB-5chcA:
undetectable
5kbwB-5chcA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE GAMMA
CHAIN


(Paracoccus
denitrificans)
PF00231
(ATP-synt)
5 LYS G 212
ASP G 220
ASN G 215
ALA G  58
VAL G  52
None
1.29A 5kbwB-5dn6G:
undetectable
5kbwB-5dn6G:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwf PEPTIDOGLYCAN
RECOGNITION PROTEIN
1


(Camelus
dromedarius)
PF01510
(Amidase_2)
5 LEU A 159
ASP A 148
GLY A 145
ALA A 124
TYR A 169
None
1.26A 5kbwB-5dwfA:
undetectable
5kbwB-5dwfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE


(Thermotoga
neapolitana)
PF00232
(Glyco_hydro_1)
5 GLU A  20
ASN A 151
VAL A 147
TYR A 144
ASN A 100
None
1.43A 5kbwB-5idiA:
undetectable
5kbwB-5idiA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii)
PF00027
(cNMP_binding)
5 LEU A 160
ASP A 170
ASN A 175
ALA A 180
VAL A 267
None
1.23A 5kbwB-5j3uA:
undetectable
5kbwB-5j3uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE


(Campylobacter
jejuni)
PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
5 ASP A 234
GLY A 236
ALA A 580
ASN A 578
TYR A 429
None
1.09A 5kbwB-5jxlA:
2.5
5kbwB-5jxlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 GLU A 780
LEU A 717
LYS A 754
ASP A 791
VAL A 489
None
1.36A 5kbwB-5mtzA:
undetectable
5kbwB-5mtzA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 GLU A 780
LEU A 717
LYS A 754
ASP A 791
VAL A 491
None
1.33A 5kbwB-5mtzA:
undetectable
5kbwB-5mtzA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owx GENOME POLYPROTEIN

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 GLY 1 132
ALA 2 131
VAL 1 129
TYR 1 130
LYS 2  80
None
1.23A 5kbwB-5owx1:
undetectable
5kbwB-5owx1:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4)
PF03576
(Peptidase_S58)
5 GLU A 127
ASP A 279
ASN A 201
ALA A 332
VAL A 325
None
1.36A 5kbwB-5tzbA:
undetectable
5kbwB-5tzbA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN


(Mobiluncus
mulieris)
no annotation 5 GLU A 216
LEU A 171
LYS A 172
ALA A 265
VAL A 255
None
1.24A 5kbwB-5u6fA:
undetectable
5kbwB-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE


(Acinetobacter
baumannii)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g)
5 ASP A 294
GLY A 292
ASN A 321
ALA A  28
ASN A   8
None
None
NA  A 601 (-3.2A)
None
None
1.00A 5kbwB-5urbA:
2.2
5kbwB-5urbA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 5 GLU A 796
LEU A 803
ASN A 765
ALA A 772
VAL A 533
None
1.43A 5kbwB-5wugA:
undetectable
5kbwB-5wugA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C


(Mycobacterium
tuberculosis)
PF01596
(Methyltransf_3)
5 GLU A  18
LEU A  49
GLY A 208
ALA A 201
VAL A 162
None
0.99A 5kbwB-5x7fA:
undetectable
5kbwB-5x7fA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Desulfovibrio
gigas)
no annotation 5 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
None
1.40A 5kbwB-5xmjA:
undetectable
5kbwB-5xmjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8l -

(-)
no annotation 5 GLY A 178
ASN A 175
ALA A 169
VAL A 142
TYR A 145
None
1.23A 5kbwB-6a8lA:
undetectable
5kbwB-6a8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A


(Ascaris suum)
no annotation 5 GLU A  35
LEU A  41
LYS A  38
GLY A  75
ALA A  54
None
1.41A 5kbwB-6bj9A:
undetectable
5kbwB-6bj9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B


(Flavobacterium
johnsoniae)
no annotation 5 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
None
1.25A 5kbwB-6btmB:
undetectable
5kbwB-6btmB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5


(Homo sapiens)
no annotation 5 GLU B  59
GLY A 858
ASN A 859
ASN A 885
TYR A 807
None
1.33A 5kbwB-6en4B:
undetectable
5kbwB-6en4B:
18.23