SIMILAR PATTERNS OF AMINO ACIDS FOR 5KBW_A_RBFA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.38A 5kbwA-1ao3A:
undetectable		 5kbwA-1ao3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 184
GLY A 324
ASN A 323
LEU A 319
ALA A 316
 None
 1.42A 5kbwA-1cliA:
undetectable		 5kbwA-1cliA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ASP B 616
GLY B 617
MET B 655
ASN B 654
LEU B 652
 None
 1.35A 5kbwA-1ej6B:
1.5		 5kbwA-1ej6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ASP B 616
GLY B 618
MET B 655
ASN B 654
LEU B 652
 None
 1.02A 5kbwA-1ej6B:
1.5		 5kbwA-1ej6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 335
MET A 331
ASN A 333
LEU A 330
ALA A  76
 None
None
NDP  A1000 (-3.1A)
None
None
 1.33A 5kbwA-1exbA:
undetectable		 5kbwA-1exbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 LEU A 175
GLY A  49
ASN A   7
LEU A   3
ALA A 186
 None
 1.39A 5kbwA-1gjuA:
0.0		 5kbwA-1gjuA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		5 GLU B 174
LEU B  86
GLY B  83
LEU B   7
ASN B  33
 None
GLU  B1401 (-4.0A)
None
None
None
 1.23A 5kbwA-1i7qB:
undetectable		 5kbwA-1i7qB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 LEU T 185
ASP T 189
GLY T 226
ASN T 224
ALA T 170
 None
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.7A)
None
None
 1.42A 5kbwA-1j17T:
undetectable		 5kbwA-1j17T:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 GLU A 137
ASP A  44
GLY A  42
ASN A  40
LEU A  39
 None
 1.34A 5kbwA-1js4A:
0.0		 5kbwA-1js4A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A  58
GLY A 274
ASN A 272
LEU A 248
ALA A 254
 None
 1.33A 5kbwA-1nu5A:
0.3		 5kbwA-1nu5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLU A 295
LEU A 166
GLY A 244
LEU A 154
ALA A 224
 MG  A 438 ( 2.9A)
None
None
None
None
 1.21A 5kbwA-1p43A:
undetectable		 5kbwA-1p43A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 ASP A 467
GLY A 488
ASN A 465
ALA A 258
ASN A 255
 TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 4.5A)
TPQ  A 466 ( 3.3A)
None
None
 1.38A 5kbwA-1qafA:
undetectable		 5kbwA-1qafA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 GLU A 232
LEU A 142
GLY A 134
ASN A 286
LEU A 287
 None
 1.12A 5kbwA-1qh4A:
undetectable		 5kbwA-1qh4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 GLU A 227
LEU A 137
GLY A 129
ASN A 281
LEU A 282
 None
 1.32A 5kbwA-1qk1A:
undetectable		 5kbwA-1qk1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 GLU A 277
LEU A 209
GLY A 203
ASN A 201
LEU A 198
 None
 1.22A 5kbwA-1r4pA:
undetectable		 5kbwA-1r4pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 GLU A 121
ASP A 212
GLY A 213
LEU A 110
ALA A  93
 GOL  A1902 (-3.3A)
None
None
None
None
 1.39A 5kbwA-1uarA:
undetectable		 5kbwA-1uarA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 GLU A 173
LEU A 179
LYS A 176
GLY A 230
LEU A 256
 None
 1.24A 5kbwA-1ujnA:
undetectable		 5kbwA-1ujnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 GLU A  72
LEU A  67
ASP A 194
GLY A 193
LEU A  64
 None
 1.41A 5kbwA-1v1pA:
undetectable		 5kbwA-1v1pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 GLY A 111
MET A 114
LEU A 118
ASN A 215
ASN A 209
 None
 1.42A 5kbwA-1vb3A:
undetectable		 5kbwA-1vb3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN A AND D
BETA CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		5 LEU B 141
GLY B 107
ASN B 135
LEU B 133
ALA B  74
 HEM  B 201 (-4.6A)
None
None
None
None
 1.40A 5kbwA-1wmuB:
undetectable		 5kbwA-1wmuB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		5 LEU A 232
GLY A 303
ASN A 180
LEU A 181
ALA A 268
 None
 1.15A 5kbwA-1ygaA:
undetectable		 5kbwA-1ygaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 LEU A 208
GLY A 233
ASN A   9
LEU A  40
ALA A  38
 None
PO4  A2004 (-3.2A)
None
None
None
 1.36A 5kbwA-1yyaA:
undetectable		 5kbwA-1yyaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 LEU A 591
GLY A 661
ASN A 541
LEU A 542
ALA A 626
 None
 1.16A 5kbwA-1z45A:
undetectable		 5kbwA-1z45A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		5 GLU A  61
LEU A  50
ASP A  56
GLY A  33
LEU A  40
 None
PHD  A  51 ( 3.8A)
None
None
None
 1.26A 5kbwA-1zy2A:
2.0		 5kbwA-1zy2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A  58
GLY A 274
ASN A 272
LEU A 248
ALA A 254
 None
 1.13A 5kbwA-2chrA:
undetectable		 5kbwA-2chrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 GLU A 450
LYS A 446
ASP A 180
GLY A 183
LEU A 191
 None
 1.16A 5kbwA-2i2xA:
2.5		 5kbwA-2i2xA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 ASP A  69
GLY A  57
ASN A  55
LEU A  52
ALA A  39
 None
 1.43A 5kbwA-2k3nA:
2.6		 5kbwA-2k3nA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka9 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLU A  79
LEU A  77
LYS A  78
ASN A  61
LEU A  86
 None
 1.29A 5kbwA-2ka9A:
undetectable		 5kbwA-2ka9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 ASP A  34
GLY A  72
ASN A  70
LEU A  69
LYS A  61
 None
 1.29A 5kbwA-2kdyA:
undetectable		 5kbwA-2kdyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 GLU A 166
LEU A 142
GLY A 124
ASN A 126
LEU A 107
 None
 1.27A 5kbwA-2o6wA:
undetectable		 5kbwA-2o6wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		5 ASP A 274
MET A  20
ASN A  19
LEU A  18
ALA A  79
 GOL  A 336 ( 4.4A)
EDO  A 333 (-3.8A)
None
None
None
 1.19A 5kbwA-2rg2A:
undetectable		 5kbwA-2rg2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		5 LEU A  58
LYS A  57
ASP A  32
GLY A  33
LEU A 309
 None
 1.12A 5kbwA-2w38A:
undetectable		 5kbwA-2w38A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 354
LYS A 342
ASN A 383
LEU A 380
ALA A 388
 None
 1.39A 5kbwA-2yjqA:
undetectable		 5kbwA-2yjqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		5 GLU A 290
ASP A 339
GLY A 340
LEU A 323
ALA A 185
 None
 1.30A 5kbwA-3a5xA:
2.6		 5kbwA-3a5xA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		5 GLU A 303
ASP A  66
GLY A  15
ASN A  63
ALA A  21
 None
 1.38A 5kbwA-3b59A:
undetectable		 5kbwA-3b59A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		5 GLU A 350
ASP A 341
GLY A 291
LEU A 387
ALA A 324
 EDO  A 494 (-3.5A)
MG  A 484 (-2.0A)
MG  A 485 ( 4.2A)
None
None
 1.36A 5kbwA-3b9tA:
undetectable		 5kbwA-3b9tA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 292
ASP A 244
GLY A 268
LEU A 282
ALA A 310
 None
 0.99A 5kbwA-3dipA:
undetectable		 5kbwA-3dipA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ASP A  79
GLY A  77
MET A  76
LEU A  29
ALA A  54
 None
 1.37A 5kbwA-3fgqA:
undetectable		 5kbwA-3fgqA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 GLY A 373
MET A 374
ASN A 426
LEU A 427
ASN A 395
 GLY  A 373 ( 0.0A)
MET  A 374 ( 0.0A)
ASN  A 426 ( 0.6A)
LEU  A 427 ( 0.5A)
ASN  A 395 ( 0.6A)
 1.32A 5kbwA-3gnrA:
1.9		 5kbwA-3gnrA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		5 GLU A  75
LEU A  70
GLY A  54
LEU A  26
ALA A 108
 None
None
APR  A 302 ( 4.1A)
None
None
 1.25A 5kbwA-3gz8A:
undetectable		 5kbwA-3gz8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		5 GLY A  22
ASN A  18
LEU A  17
ALA A  64
ASN A 264
 None
 1.35A 5kbwA-3hq0A:
undetectable		 5kbwA-3hq0A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 LEU A 124
ASP A 129
GLY A  71
LEU A  78
ALA A 173
 None
 1.15A 5kbwA-3iwjA:
undetectable		 5kbwA-3iwjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 LEU A 476
ASP A 129
GLY A  71
LEU A  78
ALA A 173
 None
 1.41A 5kbwA-3iwjA:
undetectable		 5kbwA-3iwjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 LEU A 124
ASP A 129
GLY A  71
LEU A  78
ALA A 173
 None
 1.13A 5kbwA-3iwkA:
undetectable		 5kbwA-3iwkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.12A 5kbwA-3jzjA:
undetectable		 5kbwA-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		5 GLU A 202
LYS A 199
GLY A  59
LEU A 195
ALA A 131
 None
 1.35A 5kbwA-3krcA:
undetectable		 5kbwA-3krcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLU A  80
LEU A  86
GLY A  78
LEU A  55
ALA A  70
 None
 1.25A 5kbwA-3ltmA:
undetectable		 5kbwA-3ltmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		5 LEU A  37
ASP A 214
GLY A 185
LEU A 181
ALA A 223
 None
 1.30A 5kbwA-3lubA:
undetectable		 5kbwA-3lubA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		5 ASP A 160
GLY A  56
MET A  87
ASN A  88
ASN A 206
 None
 1.30A 5kbwA-3mdoA:
undetectable		 5kbwA-3mdoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj6 BLASTICIDIN-S
DEAMINASE

(Coccidioides
immitis) 		PF00383
(dCMP_cyt_deam_1) 		5 LEU A  74
ASP A  40
GLY A  41
LEU A  13
ALA A  35
 None
 1.43A 5kbwA-3oj6A:
undetectable		 5kbwA-3oj6A:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		7 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 0.82A 5kbwA-3p5nA:
24.2		 5kbwA-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		6 LEU A  42
ASP A  81
GLY A  84
LEU A 127
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 (-4.1A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.38A 5kbwA-3p5nA:
24.2		 5kbwA-3p5nA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 LYS A  24
ASP A 410
GLY A 411
LEU A 367
ALA A 419
 None
 1.32A 5kbwA-3pplA:
undetectable		 5kbwA-3pplA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		5 GLU A 181
GLY A  27
LEU A  93
ALA A  87
ASN A  89
 None
 1.38A 5kbwA-3qa8A:
undetectable		 5kbwA-3qa8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLU A  95
ASP A  11
LEU A 146
ALA A 168
ASN A 118
 None
ZN  A 512 (-3.2A)
None
None
None
 1.24A 5kbwA-3qfkA:
undetectable		 5kbwA-3qfkA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shd PHOSPHATASE NUDJ

(Escherichia
coli) 		PF00293
(NUDIX) 		5 GLU A  55
ASN A  32
LEU A 118
ALA A 115
ASN A 117
 SO4  A 157 ( 2.4A)
SO4  A 158 ( 3.5A)
None
None
None
 1.30A 5kbwA-3shdA:
undetectable		 5kbwA-3shdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 GLU A 172
LEU A 214
GLY A 239
ASN A  10
ALA A  42
 None
 1.28A 5kbwA-3ta6A:
undetectable		 5kbwA-3ta6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 5 ASP A 552
GLY A 553
ASN A 554
ALA A 767
ASN A 717
 None
 1.41A 5kbwA-3wovA:
undetectable		 5kbwA-3wovA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLU A 128
ASP A  44
GLY A 249
LEU A 182
ASN A 151
 None
ZN  A1596 (-3.0A)
None
None
None
 1.32A 5kbwA-3zu0A:
undetectable		 5kbwA-3zu0A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ess OR187

(synthetic
construct) 		PF01661
(Macro) 		5 LYS A  54
ASP A  81
GLY A  80
ASN A  24
ALA A  92
 None
 1.34A 5kbwA-4essA:
undetectable		 5kbwA-4essA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		5 GLU A  41
LEU A  21
GLY A  62
ASN A  34
ALA A  26
 None
 1.41A 5kbwA-4fziA:
undetectable		 5kbwA-4fziA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF08703
(PLC-beta_C) 		5 GLU E1164
LEU E1158
LEU E 957
ALA E1075
ASN E1076
 None
 1.13A 5kbwA-4gnkE:
1.9		 5kbwA-4gnkE:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE

(Sphingobium
chlorophenolicum) 		PF00903
(Glyoxalase) 		5 LEU A 296
LYS A 297
GLY A 293
LEU A  50
ALA A  19
 None
 1.17A 5kbwA-4huzA:
undetectable		 5kbwA-4huzA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 LEU A 124
ASP A 129
GLY A  71
LEU A  78
ALA A 173
 None
 1.11A 5kbwA-4i8qA:
undetectable		 5kbwA-4i8qA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8)
no annotation 		5 GLU P 209
ASP P 211
GLY A 470
MET A 472
LEU A 476
 None
 1.42A 5kbwA-4lvoP:
undetectable		 5kbwA-4lvoP:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 5 GLY A  56
ASN A  18
ALA A 301
ASN A 302
ASN A 298
 None
 0.95A 5kbwA-4mc0A:
3.0		 5kbwA-4mc0A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		5 GLU A 100
LEU A  64
GLY A 138
LEU A 144
ALA A 127
 None
 1.34A 5kbwA-4n30A:
undetectable		 5kbwA-4n30A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 LEU A  16
ASP A 173
GLY A 354
LEU A 361
ALA A 114
 None
 1.22A 5kbwA-4nesA:
undetectable		 5kbwA-4nesA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 GLU A 117
LEU A  76
ASN A  79
LEU A  81
ALA A  61
 None
 1.42A 5kbwA-4ow2A:
undetectable		 5kbwA-4ow2A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk2 ALDO/KETO REDUCTASE

(Polaromonas sp.
JS666) 		PF00248
(Aldo_ket_red) 		5 GLY A 301
MET A 297
ASN A 299
LEU A 296
ALA A  51
 None
 1.43A 5kbwA-4xk2A:
undetectable		 5kbwA-4xk2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLU C 106
LEU C 112
GLY C 104
LEU C  81
ALA C  96
 None
 1.21A 5kbwA-4xl5C:
undetectable		 5kbwA-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLU C 137
LEU C 143
GLY C 135
LEU C 112
ALA C 127
 None
 1.25A 5kbwA-4xl5C:
undetectable		 5kbwA-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		5 GLU A 167
LEU A 173
ASP A 211
LEU A 106
ALA A 191
 None
 1.29A 5kbwA-4yamA:
undetectable		 5kbwA-4yamA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 GLU A 371
LYS A 367
GLY A 121
LEU A 127
ALA A 147
 None
 1.26A 5kbwA-4z5qA:
undetectable		 5kbwA-4z5qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLU A  75
LEU A  81
GLY A  73
LEU A  50
ALA A  65
 None
 1.31A 5kbwA-4zv6A:
undetectable		 5kbwA-4zv6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLU A 168
LEU A 174
GLY A 166
LEU A 143
ALA A 158
 None
 1.19A 5kbwA-4zv6A:
undetectable		 5kbwA-4zv6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 ASP A  70
GLY A  73
MET A  76
LEU A  80
ALA A  48
 None
 1.09A 5kbwA-5ey7A:
undetectable		 5kbwA-5ey7A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 GLU A 223
LEU A 434
MET A 636
LEU A 632
ALA A 455
 None
 1.36A 5kbwA-5hmpA:
undetectable		 5kbwA-5hmpA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		5 GLU A 422
LEU A 428
LYS A 425
ASP A 439
ALA A 388
 None
CMP  A 502 (-4.3A)
None
None
CMP  A 502 (-3.5A)
 1.20A 5kbwA-5kbfA:
undetectable		 5kbwA-5kbfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		5 LEU A  39
GLY A 182
ALA A  44
ASN A  47
ASN A  43
 None
None
A5A  A 500 (-3.6A)
None
None
 1.06A 5kbwA-5knnA:
3.3		 5kbwA-5knnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN

(Kutzneria
albida) 		PF09017
(Transglut_prok) 		5 LEU A 123
LYS A 122
ASN A  55
LEU A  54
ALA A 221
 None
 1.37A 5kbwA-5m6qA:
undetectable		 5kbwA-5m6qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 5 LEU A 201
ASP A 222
GLY A 220
LEU A 209
ALA A 216
 None
 1.25A 5kbwA-5m89A:
undetectable		 5kbwA-5m89A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 GLU A 445
LEU A 451
LYS A 450
GLY A 481
LEU A 478
 None
 1.11A 5kbwA-5mqsA:
undetectable		 5kbwA-5mqsA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		5 LEU A 443
LYS A 442
ASN A 393
LEU A 395
ALA A 413
 None
 1.40A 5kbwA-5nkpA:
undetectable		 5kbwA-5nkpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2m BREAST CANCER
ANTI-ESTROGEN
RESISTANCE 1

(Homo sapiens) 		PF00018
(SH3_1) 		5 ASP A  43
GLY A  44
ASN A  60
LEU A  62
ALA A  10
 None
 1.21A 5kbwA-5o2mA:
undetectable		 5kbwA-5o2mA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 5 GLU A 402
LEU A 352
LYS A 402
LEU A 391
ALA A 366
 None
 1.35A 5kbwA-5oevA:
undetectable		 5kbwA-5oevA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF02272
(DHHA1) 		5 GLY A 186
MET A 171
ASN A 188
LEU A 170
ALA A 195
 None
 1.12A 5kbwA-5t76A:
undetectable		 5kbwA-5t76A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF02272
(DHHA1) 		5 LEU A 192
GLY A 186
MET A 171
ASN A 188
LEU A 170
 None
 1.09A 5kbwA-5t76A:
undetectable		 5kbwA-5t76A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A  50
GLY A  67
LEU A  92
ALA A 154
ASN A 158
 None
 1.09A 5kbwA-5tnxA:
undetectable		 5kbwA-5tnxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 GLU A 264
LEU A 270
LYS A 267
GLY A 284
LEU A 257
 None
 1.34A 5kbwA-5u81A:
undetectable		 5kbwA-5u81A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 ASP A 294
GLY A 292
ASN A 321
ALA A  28
ASN A   8
 None
None
NA  A 601 (-3.2A)
None
None
 0.99A 5kbwA-5urbA:
undetectable		 5kbwA-5urbA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 GLU A 147
ASP A 174
GLY A 175
ALA A 183
ASN A 265
 PLR  A 401 ( 4.0A)
PLR  A 401 (-2.6A)
None
None
None
 1.36A 5kbwA-5vyeA:
undetectable		 5kbwA-5vyeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.34A 5kbwA-5xmjA:
undetectable		 5kbwA-5xmjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 LEU A 473
ASP A 497
GLY A 499
LEU A 502
ALA A 529
 None
 1.26A 5kbwA-5xpgA:
undetectable		 5kbwA-5xpgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P

(Kluyveromyces
lactis) 		no annotation 5 GLU A 186
ASP A 112
GLY A 183
LEU A 157
ALA A 107
 None
 1.42A 5kbwA-6am0A:
undetectable		 5kbwA-6am0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 GLU A  35
LEU A  41
LYS A  38
GLY A  75
ALA A  54
 None
 1.30A 5kbwA-6bj9A:
undetectable		 5kbwA-6bj9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.32A 5kbwA-6btmB:
undetectable		 5kbwA-6btmB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU R  68
LYS R  67
LEU R  72
ASN R 310
ASN R  73
 None
 1.31A 5kbwA-6cmoR:
2.5		 5kbwA-6cmoR:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1i -

(-) 		no annotation 5 GLU A 175
LYS A 171
GLY A 260
LEU A 223
ALA A 200
 MN  A 409 (-2.7A)
None
None
None
None
 1.19A 5kbwA-6g1iA:
undetectable		 5kbwA-6g1iA:
undetectable